Jiang-Hui Meng, Yong-Biao Huang, Jin Long, Qiu-Chen Cai, Xin Qiao, Qiong-Li Zhang, Li-Dan Zhang, Xiang Yan, Rui Jing, Xing-Shan Liu, Sai-Jun Zhou, Yong-Sheng Yuan, Yin-Chen Ma, Li-Xiang Zhou, Nan-Nan Peng, Xing-Cheng Li, Cheng-Hui Cai, Hong-Mei Tang, André F Martins, Jean X Jiang, Kai-Jun Luo
The extracellular superoxide dismutases (ecSODs) secreted by Microplitis bicoloratus reduce the reactive oxygen species (ROS) stimulated by the Microplitis bicoloratus bracovirus . Here, we demonstrate that the bacterial transferase hexapeptide (hexapep) motif and bacterial-immunoglobulin-like (BIg-like) domain of ecSODs bind to the cell membrane and transiently open hemichannels, facilitating ROS reductions. RNAi-mediated ecSOD silencing in vivo elevated ROS in host hemocytes, impairing parasitoid larva development...
April 19, 2024: IScience