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https://www.readbyqxmd.com/read/28168343/is-infection-the-possible-initiator-of-disc-disease-an-insight-from-proteomic-analysis
#1
S Rajasekaran, Chitraa Tangavel, Siddharth N Aiyer, Sharon Miracle Nayagam, M Raveendran, Naveen Luke Demonte, Pramela Subbaiah, Rishi Kanna, Ajoy Prasad Shetty, K Dharmalingam
STUDY DESIGN: Proteomic and 16S rDNA analysis of disc tissues obtained in vivo. OBJECTIVE: To address the controversy of infection as an aetiology for disc disorders through protein profiling. There is raging controversy over the presence of bacteria in human lumbar discs in vivo, and if they represent contamination or infection. Proteomics can provide valuable insight by identifying proteins signifying bacterial presence and, also host defence response proteins (HDRPs), which will confirm infection...
February 6, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28145578/comparision-of-gingival-and-umbilical-cord-stem-cells-based-on-its-modulus-and-neuronal-differentiation
#2
Rajasekaran Subbarayan, Murugan Girija Dinesh, Joynarayan Mukherjee, M S Ramachandra Rao, Suresh Ranga Rao
The availability of Human Umbilical Cord-derived Mesenchymal Stem Cells (HUCMSCs) from a single sex being a major limitation for the utilization of a potential stem cell, it is highly desirable to utilize, an autogenous pluripotent cell with desirable biological and mechanical properties in clinical situations. Comparison of Human Gingival Mesenchymal Stem Cells (HGMSCs) with HUCMSCs demonstrates; MSCs derived from gingiva have higher proliferation rate and higher population doubling time than Umbilical Cord...
February 1, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28110796/effectiveness-of-hindfoot-arthrodesis-by-stable-internal-fixation-in-various-eichenholtz-stages-of-neuropathic-ankle-arthropathy
#3
Silvampatty R Sundararajan, Kanchana P Srikanth, Handenahally S Nagaraja, Shanmuganathan Rajasekaran
The optimal time to treat neuropathic (Charcot) arthropathy of the ankle and peritalar joint is controversial because of the various treatment options available and the variable results reported in published studies. We sought to determine the outcome of hind foot arthrodesis with stable internal fixation in patients with different Eichenholtz stages of arthropathy. We prospectively studied patients with substantial disabilities caused by neuropathic arthropathy in deformed, unstable ankle and peritalar joints, with or without ulcerations, who had undergone treatment from July 2007 to December 2012...
January 16, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28110361/the-impact-of-routine-whole-spine-mri-screening-in-the-evaluation-of-spinal-degenerative-diseases
#4
Rishi Mugesh Kanna, Younis Kamal, Anupama Mahesh, Prakash Venugopal, Ajoy Prasad Shetty, S Rajasekaran
PURPOSE: Magnetic resonance imaging (MRI) of the spine is a sensitive investigation, which not only provides detailed images of the spinal column but also adjacent spinal regions and para-vertebral organ systems. Such incidental findings (IF) can be asymptomatic but significant. The efficacy of whole spine T2 sagittal screening in providing additional information has been demonstrated in several spinal diseases but its routine use in patients with spinal degenerative diseases has not been studied...
January 21, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28018060/isolated-dorsal-column-dysfunction-due-to-an-intraspinal-osteolipoma-case-report-and-review-of-literature
#5
Siddharth N Aiyer, Ajoy Prasad Shetty, Rishi Kanna, Anupama Maheswaran, S Rajasekaran
Osteolipoma is a rare variant of the ubiquitous lipoma. Published literature appears in the form of isolated case reports affecting soft tissue structures in the head, neck and rarely affecting the spine. We present a unique instance of an intraspinal osteolipoma in the cervical spine, without evidence of accompanying spinal dysraphism and an atypical clinical presentation of isolated dorsal column dysfunction. We describe the clinical presentation, operative procedure and post-operative outcomes with histopathological findings of this rare entity...
October 2016: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/28003122/metronomic-chemotherapy-a-relook-at-its-basis-and-rationale
#6
Tanujaa Rajasekaran, Quan-Sing Ng, Daniel Shao-Weng Tan, Wan-Teck Lim, Mei-Kim Ang, Chee-Keong Toh, Balram Chowbay, Ravindran Kanesvaran, Eng-Huat Tan
Metronomic administration of chemotherapy has long been recognized as having a different biological effect from maximal tolerated dose (MTD) administration. Preclinical studies have demonstrated these differences quite elegantly and many clinical trials have also demonstrated reproducible activity albeit small, in varied solid malignancies even in patients who were heavily pretreated. However, the concept of metronomic chemotherapy has been plagued by lack of a clear definition resulting in the published literature that is rather varied and confusing...
March 1, 2017: Cancer Letters
https://www.readbyqxmd.com/read/27876490/medial-open-wedge-high-tibial-osteotomy-for-varus-malunited-tibial-plateau-fractures
#7
S R Sundararajan, H S Nagaraja, S Rajasekaran
PURPOSE: To analyze radiologic and functional outcomes of varus malunited tibial plateau fractures managed with medial open wedge high tibial osteotomy (MOHTO). METHODS: Eighteen patients with symptomatic varus malunited tibial plateau fractures with less than stage II arthritic changes managed from July 2009 to October 2013 were included. Patients with complex intra-articular step malunions and severe arthritic changes (stage III and IV) were excluded. Initially, diagnostic arthroscopy was performed followed by MOHTO stabilized with locking plate and tricortical autograft (n = 11, 61%) or a Puddu plate and allograft (n = 7, 39%)...
November 19, 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/27833647/parametric-amplification-of-a-superconducting-plasma-wave
#8
S Rajasekaran, E Casandruc, Y Laplace, D Nicoletti, G D Gu, S R Clark, D Jaksch, A Cavalleri
Many applications in photonics require all-optical manipulation of plasma waves1, which can concentrate electromagnetic energy on sub-wavelength length scales. This is difficult in metallic plasmas because of their small optical nonlinearities. Some layered superconductors support Josephson plasma waves (JPWs)2,3, involving oscillatory tunneling of the superfluid between capacitively coupled planes. Josephson plasma waves are also highly nonlinear4, and exhibit striking phenomena like cooperative emission of coherent terahertz radiation5,6, superconductor-metal oscillations7 and soliton formation8...
November 2016: Nature Physics
https://www.readbyqxmd.com/read/27573538/ferroelectric-knbo3-nanofibers-synthesis-characterization-and-their-application-as-a-humidity-nanosensor
#9
Rajasekaran Ganeshkumar, Kostiantyn V Sopiha, Ping Wu, Chin Wei Cheah, Rong Zhao
By virtue of its non-toxicity, high T c, and non-linear optical and ferroelectric properties, one-dimensional (1D) potassium niobate (KNbO3) may enable the development of numerous nanoscale devices. Despite the progress in 1D perovskite materials, preparing high aspect ratio KNbO3 nanostructures is still a concern. This report presents the successful synthesis of ultra-long KNbO3 nanofibers using a simple sol-gel assisted far-field electrospinning process. At optimized conditions, centimeters long, orthorhombic KNbO3 nanofibers with an average diameter of 100 nm have been obtained...
September 30, 2016: Nanotechnology
https://www.readbyqxmd.com/read/27513226/how-reliable-are-the-reported-genetic-associations-in-disc-degeneration-the-influence-of-phenotypes-age-population-size-and-inclusion-sequence-in-809-patients
#10
S Rajasekaran, Rishi Mugesh Kanna, Ranjani Raja Reddy, Senthil Natesan, Muthuraja Raveendran, Kenneth M C Cheung, Danny Chan, Patrick Y P Kao, Anita Yee, Ajoy Prasad Shetty
STUDY DESIGN: Prospective genetic association study. OBJECTIVE: The aim of this study was to document the variations in the genetic associations, when different magnetic resonance imaging (MRI) phenotypes, age stratification, cohort size, and sequence of cohort inclusion are varied in the same study population. SUMMARY OF BACKGROUND DATA: Genetic associations with disc degeneration have shown high inconsistency, generally attributed to hereditary factors and ethnic variations...
November 1, 2016: Spine
https://www.readbyqxmd.com/read/27497753/measurement-of-kyphosis-and-vertebral-body-height-loss-in-traumatic-spine-fractures-an-international-study
#11
Said Sadiqi, Jorrit-Jan Verlaan, A Mechteld Lehr, Jens R Chapman, Marcel F Dvorak, Frank Kandziora, S Rajasekaran, Klaus J Schnake, Alexander R Vaccaro, F Cumhur Oner
PURPOSE: To investigate whether wide variations are seen in the measurement techniques preferred by spine surgeons around the world to assess traumatic fracture kyphosis and vertebral body height loss (VBHL). METHODS: An online survey was conducted at two time points among an international community of spine trauma experts from all world regions. The first survey (TL-survey) focused on the thoracic, thoracolumbar and lumbar spine, the second survey (C-survey) on the subaxial cervical spine...
August 6, 2016: European Spine Journal
https://www.readbyqxmd.com/read/27464577/disruption-of-desmin-mitochondrial-architecture-in-patients-with-regurgitant-mitral-valves-and-preserved-ventricular-function
#12
Mustafa I Ahmed, Jason L Guichard, Namakkal S Rajasekaran, Shama Ahmad, Nithya Mariappan, Silvio Litovsky, Himanshu Gupta, Steven G Lloyd, Thomas S Denney, Pamela Cox Powell, Inmaculada Aban, James F Collawn, James E Davies, David C McGiffin, Louis J Dell'Italia
OBJECTIVE: Recent studies have demonstrated improved outcomes in patients receiving early surgery for degenerative mitral regurgitation (MR) rather than adhering to conventional guidelines for surgical intervention. However, studies providing a mechanistic basis for these findings are limited. METHODS: Left ventricular (LV) myocardium from 22 patients undergoing mitral valve repair for American Heart Association class I indications was evaluated for desmin, the voltage-dependent anion channel, α-B-crystallin, and α, β-unsaturated aldehyde 4-hydroxynonenal by fluorescence microscopy...
October 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27378947/exercise-nrf2-and-antioxidant-signaling-in-cardiac-aging
#13
REVIEW
Madhusudhanan Narasimhan, Namakkal S Rajasekaran
Aging is represented by a progressive decline in cellular functions. The age-related deformities in cardiac behaviors are the loss of cardiac myocytes through apoptosis or programmed cell death. Oxidative stress (OS) and its deleterious consequence contribute to age-related mechanical remodeling, reduced regenerative capacity, and apoptosis in cardiac tissue. The pathogenesis of OS in the elderly can predispose the heart to other cardiac complications such as atherosclerosis, hypertension, ischemic heart disease, cardiac myopathy, and so on...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27372945/universal-disease-specific-outcome-instruments-for-spine-trauma-a-global-perspective-on-relevant-parameters-to-evaluate-clinical-and-functional-outcomes-of-thoracic-and-lumbar-spine-trauma-patients
#14
Said Sadiqi, Jorrit-Jan Verlaan, A Mechteld Lehr, Marcel F Dvorak, Frank Kandziora, S Rajasekaran, Klaus J Schnake, Alexander R Vaccaro, F Cumhur Oner
PURPOSE: Besides a patient reported outcome measure, the AOSpine Knowledge Forum Trauma aims to develop a new concept of a surgeon reported outcome measure (SROM) for spine trauma patients. This study aims to identify parameters that spine surgeons consider relevant to evaluate clinical and functional outcomes of thoracic and lumbar spine trauma patients. METHODS: An international cross-sectional web-based survey was conducted among spine surgeons from the five AOSpine International world regions...
July 2, 2016: European Spine Journal
https://www.readbyqxmd.com/read/27338106/nuclear-factor-erythroid-2-related-factor-2-in-aging-and-lung-fibrosis
#15
REVIEW
Shobha M Swamy, Namakkal S Rajasekaran, Victor J Thannickal
Aging and age-related diseases have been associated with elevated oxidative stress, which may be related to increased production of reactive species and/or a deficiency in antioxidant defenses. The nuclear factor-erythroid-2-related factor 2 (Nrf2)-mediated antioxidant response pathway maintains cellular reduction-oxidation homeostasis by inducing the transcription of an array of cytoprotective genes. However, there is evidence of impaired Nrf2 response in aging contributing to age-related fibrotic diseases...
July 2016: American Journal of Pathology
https://www.readbyqxmd.com/read/27322677/regulation-of-epithelial-to-mesenchymal-transition-using-biomimetic-fibrous-scaffolds
#16
Anitha Ravikrishnan, Tugba Ozdemir, Mohamed Bah, Karen A Baskerville, S Ismat Shah, Ayyappan K Rajasekaran, Xinqiao Jia
Epithelial-to-mesenchymal transition (EMT) is a well-studied biological process that takes place during embryogenesis, carcinogenesis, and tissue fibrosis. During EMT, the polarized epithelial cells with a cuboidal architecture adopt an elongated fibroblast-like morphology. This process is accompanied by the expression of many EMT-specific molecular markers. Although the molecular mechanism leading to EMT has been well-established, the effects of matrix topography and microstructure have not been clearly elucidated...
July 20, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27293295/trends-in-scientific-publications-of-indian-spine-surgeons-over-14-years-2000-2013
#17
Rishi Mugesh Kanna, Asdrubal Falavigna, Pedro Guarise da Silva, Francine Wurzius Quadros, Luiz Henrique Merlin, Lucas Radaelli, Juan Pablo Guyot, Diego Dozza, Daniel K Riew, Délio Martins, Kawaguchi Yoshiharu, S Rajasekaran
BACKGROUND: The number and quality of scientific publications reflects the standards of scientific research in a country. However, the contribution of Indian spine surgeons toward global publications is unknown. The goal is to study the publications of Indian spine surgeons between 2000 and 2013. MATERIALS AND METHODS: A literature search of the publications by Indian spine surgeons was performed using MEDLINE. The search terms used were India and several spine-related terminologies...
May 2016: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/27242783/signaling-in-effector-lymphocytes-insights-toward-safer-immunotherapy
#18
REVIEW
Kamalakannan Rajasekaran, Matthew J Riese, Sridhar Rao, Li Wang, Monica S Thakar, Charles L Sentman, Subramaniam Malarkannan
Receptors on T and NK cells systematically propagate highly complex signaling cascades that direct immune effector functions, leading to protective immunity. While extensive studies have delineated hundreds of signaling events that take place upon receptor engagement, the precise molecular mechanism that differentially regulates the induction or repression of a unique effector function is yet to be fully defined. Such knowledge can potentiate the tailoring of signal transductions and transform cancer immunotherapies...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27242268/redox-biology-and-the-interface-between-bioenergetics-autophagy-and-circadian-control-of-metabolism
#19
REVIEW
Adam R Wende, Martin E Young, John Chatham, Jianhua Zhang, Namakkal S Rajasekaran, Victor M Darley-Usmar
Understanding molecular mechanisms that underlie the recent emergence of metabolic diseases such as diabetes and heart failure has revealed the need for a multi-disciplinary research integrating the key metabolic pathways which change the susceptibility to environmental or pathologic stress. At the physiological level these include the circadian control of metabolism which aligns metabolism with temporal demand. The mitochondria play an important role in integrating the redox signals and metabolic flux in response to the changing activities associated with chronobiology, exercise and diet...
November 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/27226569/macrophage-migration-inhibitory-factor-cxcr4-receptor-interactions-evidence-for-partial-allosteric-agonism-in-comparison-with-cxcl12-chemokine
#20
Deepa Rajasekaran, Sabine Gröning, Corinna Schmitz, Swen Zierow, Natalie Drucker, Maria Bakou, Kristian Kohl, André Mertens, Hongqi Lue, Christian Weber, Annie Xiao, Gary Luker, Aphrodite Kapurniotu, Elias Lolis, Jürgen Bernhagen
An emerging number of non-chemokine mediators are found to bind to classical chemokine receptors and to elicit critical biological responses. Macrophage migration inhibitory factor (MIF) is an inflammatory cytokine that exhibits chemokine-like activities through non-cognate interactions with the chemokine receptors CXCR2 and CXCR4, in addition to activating the type II receptor CD74. Activation of the MIF-CXCR2 and -CXCR4 axes promotes leukocyte recruitment, mediating the exacerbating role of MIF in atherosclerosis and contributing to the wealth of other MIF biological activities...
July 22, 2016: Journal of Biological Chemistry
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