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https://www.readbyqxmd.com/read/28515695/chronic-endurance-exercise-impairs-cardiac-structure-and-function-in-middle-aged-mice-with-impaired-nrf2-signaling
#1
Gobinath Shanmugam, Madhusudhanan Narasimhan, Robbie L Conley, Thiagarajan Sairam, Ashutosh Kumar, Ronald P Mason, Ramalingam Sankaran, John R Hoidal, Namakkal S Rajasekaran
Nuclear factor erythroid 2 related factor 2 (Nrf2) signaling maintains the redox homeostasis and its activation is shown to suppress cardiac maladaptation. Earlier we reported that acute endurance exercise (2 days) evoked antioxidant cytoprotection in young WT animals but not in aged WT animals. However, the effect of repeated endurance exercise during biologic aging (WT) characterized by an inherent deterioration in Nrf2 signaling and pathological aging (pronounced oxidative susceptibility-Nrf2 absence) in the myocardium remains elusive...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28507966/ipsilateral-hip-and-knee-dislocation-with-open-tibial-fracture-a-case-report-of-a-limb-threatening-injury
#2
Ramesh Perumal, S R Sundararajan, J Vasudeva, S Rajasekaran
INTRODUCTION: Hip or knee dislocations are usually treated as a surgical emergency, but ipsilateral hip and knee dislocation should be considered a dual emergency that must be addressed immediately and reduced at the earliest. We present here the sequence of events and the final functional outcome of one such rare injury manages by us. CASE REPORT: A 22-year-old male was involved in a road traffic accident. He presented to the emergency department in 4 h injury time with painful deformities of the right hip and knee, along with Type I open wound right leg with abnormal mobility suggestive of fracture in the ipsilateral leg...
November 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28484883/delayed-chance-fracture-pattern-injury-in-a-case-of-skeletal-fluorosis
#3
Srikanth Reddy Dumpa, Siddharth N Aiyer, Sreekanth Reddy Rajoli, Ajoy Prasad Shetty, S Rajasekaran
PURPOSE: To document a rare complication of a delayed 'chance fracture pattern'-type injury through the proximal end of a pedicle screw construct in the clinical scenario of skeletal fluorosis. METHODS: A 72-year-old man with fluorosis presented following a fall which resulted in a T12-L1 fracture. Investigations revealed an unstable three-column injury, so the patient was treated with surgical stabilisation using pedicle screw fixation from T11 to L2. He presented 1 month following surgery with worsening back pain...
May 8, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28482326/constitutive-activation-of-nrf2-induces-a-stable-reductive-state-in-the-mouse-myocardium
#4
Gobinath Shanmugam, Madhusudhanan Narasimhan, Susan Tamowski, Victor Darley-Usmar, Namakkal S Rajasekaran
Redox homeostasis regulates key cellular signaling pathways in both physiology and pathology. The cell's antioxidant response provides a defense against oxidative stress and establishes a redox tone permissive for cell signaling. The molecular regulation of the well-known Keap1/Nrf2 system acts as sensor responding to changes in redox homeostasis and is poorly studied in the heart. Importantly, it is not yet known whether Nrf2 alone can serve as a master regulator of cellular redox homeostasis without compensation of the transcriptional regulation of antioxidant response element (ARE) genes through alternate mechanisms...
May 3, 2017: Redox Biology
https://www.readbyqxmd.com/read/28368928/bilateral-avascular-necrosis-of-the-femoral-head-following-asynchronous-postictal-femoral-neck-fractures-a-case-report-and-review-of-the-literature
#5
K Venkatadass, M Avinash, S Rajasekaran
Bilateral avascular necrosis (AVN) following postictal bilateral fracture neck of the femur is a rare occurrence. Here, we report a case of bilateral AVN of the femoral head following an asynchronous bilateral postictal fracture neck of the femur. A 16-year-old autistic boy presented with left hip pain following an episode of seizures and radiographs showed Delbet type II fracture neck of the left femur. This was treated by closed reduction and cancellous screw fixation and skeletal traction for 6 weeks. At 3 months, follow-up radiograph showed union of the fracture, but he had developed segmental AVN with collapse of the head...
March 31, 2017: Journal of Pediatric Orthopedics. Part B
https://www.readbyqxmd.com/read/28368632/dynamical-stability-limit-for-the-charge-density-wave-in-k_-0-3-moo_-3
#6
R Mankowsky, B Liu, S Rajasekaran, H Y Liu, D Mou, X J Zhou, R Merlin, M Först, A Cavalleri
We study the response of the one-dimensional charge density wave in K_{0.3}MoO_{3} to different types of excitation with femtosecond optical pulses. We compare direct excitation of the lattice at midinfrared frequencies with injection of quasiparticles across the low energy charge density wave gap and with charge transfer excitation in the near infrared. For all three cases, we observe a fluence threshold above which the amplitude-mode oscillation frequency is softened and the mode becomes increasingly damped...
March 17, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28331279/unplanned-90-day-readmissions-in-a-specialty-orthopaedic-unit-a-prospective-analysis-of-consecutive-12729-admissions
#7
Mahender Avinash, S Rajasekaran, Siddharth N Aiyer
INTRODUCTION: Unplanned readmissions are an undesirable and expensive outcome of clinical practice. Previous reported literature is limited by retrospective study designs and 30 day study intervals. We analyzed causes for 90-day unplanned readmission, temporal occurrence of major causes, possible predisposing factors, bed days lost and economic impact. MATERIALS & METHODS: A prospective analysis of 12729 admissions was performed over 1 year in an Orthopaedic unit...
June 2017: Journal of Orthopaedics
https://www.readbyqxmd.com/read/28314996/development-of-the-aospine-patient-reported-outcome-spine-trauma-aospine-prost-a-universal-disease-specific-outcome-instrument-for-individuals-with-traumatic-spinal-column-injury
#8
Said Sadiqi, A Mechteld Lehr, Marcel W Post, Marcel F Dvorak, Frank Kandziora, S Rajasekaran, Klaus J Schnake, Alexander R Vaccaro, F Cumhur Oner
PURPOSE: To report on the multi-phase process used in developing the AOSpine Patient Reported Outcome Spine Trauma (AOSpine PROST), as well as the results of its application in a pilot study. METHODS: The International Classification of Functioning, Disability and Health (ICF) methodology was used as the basis for the development of this tool. Four preparatory studies and a consensus conference were performed, and resulted in the selection of 25 core ICF categories as well as the scale for use...
March 17, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28288400/c-phycocyanin-suppresses-transforming-growth-factor-%C3%AE-1-induced-epithelial-mesenchymal-transition-in-human-epithelial-cells
#9
Dhamotharan Pattarayan, Dheeran Rajarajan, Sivanantham Ayyanar, Rajaguru Palanichamy, Rajasekaran Subbiah
BACKGROUND: Epithelial mesenchymal transition (EMT) is a process through which epithelial cells undergo multiple biochemical changes, causing them to differentiate into a mesenchymal-cell phenotype. This process has been shown to contribute to the development of fibrotic diseases. C-phycocyanin (C-PC) is a phycobiliprotein extracted from Spirulina platensis. This study was done to investigate the effect of C-PC on transforming growth factor-β1 (TGF-β1)-induced EMT and an EMT associated proliferation in human epithelial cell lines...
June 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28266021/gingival-spheroids-possess-multilineage-differentiation-potential
#10
Rajasekaran Subbarayan, Dinesh Murugan Girija, Suresh Ranga Rao
Recently studies have demonstrated HGMSCs as ideal candidates for regenerative study. Interestingly we found that HGMSCs derived spheroids are more potent and maintain the properties of stemness convincingly compared to conventional culture methods. During the culture, GMSCs instinctively accumulated into spheroids and display multipotent STRO-1 and Vimentin-positive cells. Reduced phenotypic expression of CD73, CD105 and, elevated expression STRO-1 and CD-34. Pluripotent nature of S-GMSCs putatively shown the expression of OCT4A, NANOG, SOX-2, SSEA4, TRA-1-60, and TRA-181...
March 7, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28168343/issls-prize-in-clinical-science-2017-is-infection-the-possible-initiator-of-disc-disease-an-insight-from-proteomic-analysis
#11
S Rajasekaran, Chitraa Tangavel, Siddharth N Aiyer, Sharon Miracle Nayagam, M Raveendran, Naveen Luke Demonte, Pramela Subbaiah, Rishi Kanna, Ajoy Prasad Shetty, K Dharmalingam
STUDY DESIGN: Proteomic and 16S rDNA analysis of disc tissues obtained in vivo. OBJECTIVE: To address the controversy of infection as an aetiology for disc disorders through protein profiling. There is raging controversy over the presence of bacteria in human lumbar discs in vivo, and if they represent contamination or infection. Proteomics can provide valuable insight by identifying proteins signifying bacterial presence and, also host defence response proteins (HDRPs), which will confirm infection...
February 6, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28145578/comparision-of-gingival-and-umbilical-cord-stem-cells-based-on-its-modulus-and-neuronal-differentiation
#12
Rajasekaran Subbarayan, Murugan Girija Dinesh, Joynarayan Mukherjee, M S Ramachandra Rao, Suresh Ranga Rao
The availability of Human Umbilical Cord-derived Mesenchymal Stem Cells (HUCMSCs) from a single sex being a major limitation for the utilization of a potential stem cell, it is highly desirable to utilize, an autogenous pluripotent cell with desirable biological and mechanical properties in clinical situations. Comparison of Human Gingival Mesenchymal Stem Cells (HGMSCs) with HUCMSCs demonstrates; MSCs derived from gingiva have higher proliferation rate and higher population doubling time than Umbilical Cord...
February 1, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28110796/effectiveness-of-hindfoot-arthrodesis-by-stable-internal-fixation-in-various-eichenholtz-stages-of-neuropathic-ankle-arthropathy
#13
Silvampatty R Sundararajan, Kanchana P Srikanth, Handenahally S Nagaraja, Shanmuganathan Rajasekaran
The optimal time to treat neuropathic (Charcot) arthropathy of the ankle and peritalar joint is controversial because of the various treatment options available and the variable results reported in published studies. We sought to determine the outcome of hind foot arthrodesis with stable internal fixation in patients with different Eichenholtz stages of arthropathy. We prospectively studied patients with substantial disabilities caused by neuropathic arthropathy in deformed, unstable ankle and peritalar joints, with or without ulcerations, who had undergone treatment from July 2007 to December 2012...
March 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28110361/the-impact-of-routine-whole-spine-mri-screening-in-the-evaluation-of-spinal-degenerative-diseases
#14
Rishi Mugesh Kanna, Younis Kamal, Anupama Mahesh, Prakash Venugopal, Ajoy Prasad Shetty, S Rajasekaran
PURPOSE: Magnetic resonance imaging (MRI) of the spine is a sensitive investigation, which not only provides detailed images of the spinal column but also adjacent spinal regions and para-vertebral organ systems. Such incidental findings (IF) can be asymptomatic but significant. The efficacy of whole spine T2 sagittal screening in providing additional information has been demonstrated in several spinal diseases but its routine use in patients with spinal degenerative diseases has not been studied...
January 21, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28018060/isolated-dorsal-column-dysfunction-due-to-an-intraspinal-osteolipoma-case-report-and-review-of-literature
#15
Siddharth N Aiyer, Ajoy Prasad Shetty, Rishi Kanna, Anupama Maheswaran, S Rajasekaran
Osteolipoma is a rare variant of the ubiquitous lipoma. Published literature appears in the form of isolated case reports affecting soft tissue structures in the head, neck and rarely affecting the spine. We present a unique instance of an intraspinal osteolipoma in the cervical spine, without evidence of accompanying spinal dysraphism and an atypical clinical presentation of isolated dorsal column dysfunction. We describe the clinical presentation, operative procedure and post-operative outcomes with histopathological findings of this rare entity...
October 2016: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/28003122/metronomic-chemotherapy-a-relook-at-its-basis-and-rationale
#16
Tanujaa Rajasekaran, Quan-Sing Ng, Daniel Shao-Weng Tan, Wan-Teck Lim, Mei-Kim Ang, Chee-Keong Toh, Balram Chowbay, Ravindran Kanesvaran, Eng-Huat Tan
Metronomic administration of chemotherapy has long been recognized as having a different biological effect from maximal tolerated dose (MTD) administration. Preclinical studies have demonstrated these differences quite elegantly and many clinical trials have also demonstrated reproducible activity albeit small, in varied solid malignancies even in patients who were heavily pretreated. However, the concept of metronomic chemotherapy has been plagued by lack of a clear definition resulting in the published literature that is rather varied and confusing...
March 1, 2017: Cancer Letters
https://www.readbyqxmd.com/read/27876490/medial-open-wedge-high-tibial-osteotomy-for-varus-malunited-tibial-plateau-fractures
#17
S R Sundararajan, H S Nagaraja, S Rajasekaran
PURPOSE: To analyze radiologic and functional outcomes of varus malunited tibial plateau fractures managed with medial open wedge high tibial osteotomy (MOHTO). METHODS: Eighteen patients with symptomatic varus malunited tibial plateau fractures with less than stage II arthritic changes managed from July 2009 to October 2013 were included. Patients with complex intra-articular step malunions and severe arthritic changes (stage III and IV) were excluded. Initially, diagnostic arthroscopy was performed followed by MOHTO stabilized with locking plate and tricortical autograft (n = 11, 61%) or a Puddu plate and allograft (n = 7, 39%)...
March 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/27833647/parametric-amplification-of-a-superconducting-plasma-wave
#18
S Rajasekaran, E Casandruc, Y Laplace, D Nicoletti, G D Gu, S R Clark, D Jaksch, A Cavalleri
Many applications in photonics require all-optical manipulation of plasma waves1, which can concentrate electromagnetic energy on sub-wavelength length scales. This is difficult in metallic plasmas because of their small optical nonlinearities. Some layered superconductors support Josephson plasma waves (JPWs)2,3, involving oscillatory tunneling of the superfluid between capacitively coupled planes. Josephson plasma waves are also highly nonlinear4, and exhibit striking phenomena like cooperative emission of coherent terahertz radiation5,6, superconductor-metal oscillations7 and soliton formation8...
November 2016: Nature Physics
https://www.readbyqxmd.com/read/27573538/ferroelectric-knbo3-nanofibers-synthesis-characterization-and-their-application-as-a-humidity-nanosensor
#19
Rajasekaran Ganeshkumar, Kostiantyn V Sopiha, Ping Wu, Chin Wei Cheah, Rong Zhao
By virtue of its non-toxicity, high T c, and non-linear optical and ferroelectric properties, one-dimensional (1D) potassium niobate (KNbO3) may enable the development of numerous nanoscale devices. Despite the progress in 1D perovskite materials, preparing high aspect ratio KNbO3 nanostructures is still a concern. This report presents the successful synthesis of ultra-long KNbO3 nanofibers using a simple sol-gel assisted far-field electrospinning process. At optimized conditions, centimeters long, orthorhombic KNbO3 nanofibers with an average diameter of 100 nm have been obtained...
September 30, 2016: Nanotechnology
https://www.readbyqxmd.com/read/27513226/how-reliable-are-the-reported-genetic-associations-in-disc-degeneration-the-influence-of-phenotypes-age-population-size-and-inclusion-sequence-in-809-patients
#20
S Rajasekaran, Rishi Mugesh Kanna, Ranjani Raja Reddy, Senthil Natesan, Muthuraja Raveendran, Kenneth M C Cheung, Danny Chan, Patrick Y P Kao, Anita Yee, Ajoy Prasad Shetty
STUDY DESIGN: Prospective genetic association study. OBJECTIVE: The aim of this study was to document the variations in the genetic associations, when different magnetic resonance imaging (MRI) phenotypes, age stratification, cohort size, and sequence of cohort inclusion are varied in the same study population. SUMMARY OF BACKGROUND DATA: Genetic associations with disc degeneration have shown high inconsistency, generally attributed to hereditary factors and ethnic variations...
November 1, 2016: Spine
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