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https://www.readbyqxmd.com/read/28796921/transition-metal-titanophosphates-with-intercalated-molecular-photoluminescence-and-catalytic-properties
#1
Sue-Lein Wang, Ling-I Hung, Pei-Lin Chen, Jia-Hao Yang, Chi-How Peng
In this study, α-TiP layers incorporated with a heterometal for organic ligand binding to enhance structural complexity and functionality were prepared. The protons of the α-TiP layer were replaced by zinc ions coordinated by 4-pyridinecarboxylic acid (PCA) and water to form a layer structure, TiZn(PO₄)₂(H₂O)(PCA) (1). The tetrahedral zinc center with coordinated water in 1 is unprecedented in zincophosphate or zinc-MOF system but only found in metalloenzymes system. The neutral zincotitanophosphate layers, tightly stacked via hydrogen bonds, showed velcro-like behavior on intercalating 4,4'-trimethylenedipyridine (TMDP) reversibly...
August 10, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28793345/cloning-and-expression-analysis-of-bmyki-gene-in-silkworm-bombyx-mori
#2
Wenhui Zeng, Riyuan Wang, Tianyang Zhang, Chunying Gong, Weidong Zuo, Rongpeng Liu, Yao Ou, Hanfu Xu
The transcriptional coactivator Yorkie(Yki), is a critical downstream effector of the Hippo(Hpo) signaling pathway that controls organ size through the regulation of cell proliferation and apoptosis. During the past ten years the biological function of Yki has been studied extensively in Drosophila and a few other insects, however, little is known about it in the silkworm, Bombyx mori, a major research model of lepidopteran insect. Here, we describe the isolation, characterization and expression of the B. mori Yki ortholog, BmYki...
2017: PloS One
https://www.readbyqxmd.com/read/28774602/chloramination-of-wastewater-effluent-toxicity-and-formation-of-disinfection-byproducts
#3
Julien Le Roux, Michael J Plewa, Elizabeth D Wagner, Maolida Nihemaiti, Azra Dad, Jean-Philippe Croué
The reclamation and disinfection of waters impacted by human activities (e.g., wastewater effluent discharges) are of growing interest for various applications but has been associated with the formation of toxic nitrogenous disinfection byproducts (N-DBPs). Monochloramine used as an alternative disinfectant to chlorine can be an additional source of nitrogen in the formation of N-DBPs. Individual toxicity assays have been performed on many DBPs, but few studies have been conducted with complex mixtures such as wastewater effluents...
August 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28765969/ampk-activation-restores-ischemic-post%C3%A2-conditioning-cardioprotection-in-stz%C3%A2-induced-type-1-diabetic-rats-role-of-autophagy
#4
Bin Zhou, Yan Leng, Shao-Qing Lei, Zhong-Yuan Xia
Although the mechanism remains unclear, ischemic post‑conditioning (IPO) is a promising approach to combat myocardial ischemia reperfusion (IR) injury; however, it has been proven ineffective in diabetes. The present study aimed to identify whether hyperglycemia‑induced AMP‑activated protein kinase (AMPK) inhibition contributes to the ineffectiveness of IPO via autophagy attenuation in diabetic hearts. Diabetic and non‑diabetic rats were subjected to myocardial IR and/or IPO with/without treatment with the AMPK activator A‑769662 and/or autophagy inhibitor 3‑methyladenine (3‑MA)...
September 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28689652/field-evaluation-of-candidate-baits-for-oral-delivery-of-bcg-vaccine-to-european-badgers-meles-meles
#5
Kate Palphramand, Richard Delahay, Andrew Robertson, Sonya Gowtage, Gareth A Williams, Robbie A McDonald, Mark Chambers, Stephen P Carter
The control of tuberculosis (TB) in cattle in the UK and Ireland is compromised by transmission of Mycobacterium bovis to cattle from the European badger (Meles meles), which acts as a wildlife reservoir. Vaccination of badgers could potentially contribute to TB control but the only licensed vaccine is injectable BadgerBCG which requires the live-capture of badgers. Current research is aimed at developing an oral TB vaccine (where vaccine is contained within bait) that is intended to be more cost-effective to deploy over large areas...
July 6, 2017: Vaccine
https://www.readbyqxmd.com/read/28669419/identification-of-associated-genes-and-diseases-in-patients-with-congenital-upper-limb-anomalies-a-novel-application-of-the-omt-classification
#6
Martijn Baas, Andrew P Stubbs, David B van Zessen, Robert-Jan H Galjaard, Peter J van der Spek, Steven E R Hovius, Christianne A van Nieuwenhoven
PURPOSE: Congenital upper-limb anomalies (CULA) can present as a part of a syndrome or association. There is a wide spectrum of CULA, each of which might be related to different diseases. The structure provided by the Oberg, Manske, and Tonkin (OMT) classification could aid in differential diagnosis formulation in patients with CULA. The aims of this study were to review the Human Phenotype Ontology (HPO) project database for diseases and causative genes related to the CULA described in the OMT classification and to develop a methodology for differential diagnosis formulation based on the observed congenital anomalies, CulaPhen...
July 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28667262/the-hippo-pathway-acts-downstream-of-the-hedgehog-signaling-to-regulate-follicle-stem-cell-maintenance-in-the-drosophila-ovary
#7
Ta-Hsing Hsu, Chia-Yu Yang, Tsung-Han Yeh, Yi-Chia Huang, Tsu-Wei Wang, Jenn-Yah Yu
The Hippo pathway is conserved and plays important roles in organ size control. The core components of the Hippo pathway are two kinases Hippo (Hpo), Warts (Wts), and a transcription-co-activator Yorkie (Yki). Yki activity is regulated by phosphorylation, which affects its nuclear localization and stability. To determine the role of the Hippo pathway in stem cells, we examine follicle stem cells (FSCs) in the Drosophila ovary. Yki is detected in the nucleus of FSCs. Knockdown of yki in the follicle cell lineage leads to a disruption of the follicular epithelium...
June 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28665539/minimalistic-liquid-assisted-route-to-highly-crystalline-%C3%AE-zirconium-phosphate
#8
Yu Cheng, Xiaodong Tony Wang, Stephan Jaenicke, Gaik-Khuan Chuah
Zirconium phosphates have potential applications in areas of ion-exchange, catalysis, photochemistry, and biotechnology. However, synthesis methodologies to form crystalline α-zirconium phosphate (Zr(HPO₄)₂·H₂O) typically involve the use of excess phosphoric acid, addition of HF or oxalic acid and long reflux times or hydrothermal conditions. Herein we report on a minimalistic sustainable route using only zirconium oxychloride and concentrated phosphoric acid to form highly crystalline α-zirconium phosphate within hours...
June 30, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28655931/genome-wide-dna-methylation-analysis-of-the-porcine-hypothalamus-pituitary-ovary-axis
#9
Xiao-Long Yuan, Zhe Zhang, Bin Li, Ning Gao, Hao Zhang, Per Torp Sangild, Jia-Qi Li
Previous studies have suggested that DNA methylation in both CpG and CpH (where H = C, T or A) contexts plays a critical role in biological functions of different tissues. However, the genome-wide DNA methylation patterns of porcine hypothalamus-pituitary-ovary (HPO) tissues remain virtually unexplored. In this study, methylomes of HPO tissues were profiled to investigate their differences and similarities. We found that HPO methylomes displayed tissue-specific methylation patterns in both CpG and CpH contexts...
June 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28620086/a-genetic-screen-reveals-an-unexpected-role-for-yorkie-signaling-in-jak-stat-dependent-hematopoietic-malignancies-in-drosophila-melanogaster
#10
Abigail M Anderson, Alessandro A Bailetti, Elizabeth Rodkin, Atish De, Erika A Bach
A gain-of-function mutation in the tyrosine kinase JAK2 (JAK2(V617F) ) causes human myeloproliferative neoplasms (MPNs). These patients present with high numbers of myeloid lineage cells and have numerous complications. Since current MPN therapies are not curative, there is a need to find new regulators and targets of JAK/STAT signaling that may represent additional clinical interventions. Drosophila melanogaster offers a low complexity model to study MPNs as JAK/STAT signaling is simplified with only one JAK (Hopscotch (Hop)) and one STAT (Stat92E)...
June 15, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28586412/high-fat-diet-and-female-fertility
#11
Natalie M Hohos, Malgorzata E Skaznik-Wikiel
The prevalence of obesity is high among reproductive age women and is associated with impaired reproductive function. Obesity is multifactorial in origin, yet many cases of obesity result from overconsumption of a diet high in fat. Excess dietary fat increases both adipose and non-adipose tissue lipid content, and through lipotoxicity leads to cell dysfunction and death. High dietary fat intake, with or without the development of obesity, impairs female hypothalamic-pituitary-ovarian (HPO) axis functionality and fertility...
June 6, 2017: Endocrinology
https://www.readbyqxmd.com/read/28549065/c-elegans-daf-16-foxo-interacts-with-tgf-%C3%A3-bmp-signaling-to-induce-germline-tumor-formation-via-mtorc1-activation
#12
Wenjing Qi, Yijian Yan, Dietmar Pfeifer, Erika Donner V Gromoff, Yimin Wang, Wolfgang Maier, Ralf Baumeister
Activation of the FOXO transcription factor DAF-16 by reduced insulin/IGF signaling (IIS) is considered to be beneficial in C. elegans due to its ability to extend lifespan and to enhance stress resistance. In the germline, cell-autonomous DAF-16 activity prevents stem cell proliferation, thus acting tumor-suppressive. In contrast, hypodermal DAF-16 causes a tumorous germline phenotype characterized by hyperproliferation of the germline stem cells and rupture of the adjacent basement membrane. Here we show that cross-talk between DAF-16 and the transforming growth factor ß (TGFß)/bone morphogenic protein (BMP) signaling pathway causes germline hyperplasia and results in disruption of the basement membrane...
May 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28542567/effects-of-age-and-weaning-conditions-on-blood-indicators-of-oxidative-status-in-pigs
#13
Arnaud Buchet, Catherine Belloc, Mily Leblanc-Maridor, Elodie Merlot
Weaning is a source of social, nutritional and environmental disorders that challenge piglet health. This study assesses the relevance of using plasma indicators of oxidative status as biomarkers of health around weaning in pigs. Blood antioxidant potential (BAP), hydroperoxides (HPO), oxidative stress index (OSI, e.g. HPO/BAP), vitamin A and E concentrations were investigated in two different trials. Trial A was carried out in an experimental unit to investigate the effects of age (from 12 to 147 days of age), weaning (at 21 or 28 days of age) and management at weaning (in optimal (OC) or deteriorated (DC) conditions) on those parameters...
2017: PloS One
https://www.readbyqxmd.com/read/28530575/effects-of-ergothioneine-rich-mushroom-extracts-on-lipid-oxidation-and-discoloration-in-salmon-muscle-stored-at-low-temperatures
#14
Jade Pahila, Hisayuki Kaneda, Reiko Nagasaka, Tomoyuki Koyama, Toshiaki Ohshima
The effects of supplementing ergothioneine-rich mushroom extracts (ME) on discoloration and lipid oxidation in astaxanthin-pigmented salmon muscles were evaluated. ME (Flammulina velutipes) were added (in vitro) to minced Oncorhynchus mykiss muscles and stored at -10°C. During several weeks of storage, the ME-treated group showed lower lipid hydroperoxide (HPO) accumulation and higher retained astaxanthin levels than in the control group. The effects of adding concentrated ME (Pleurotus cornucopiae) to Oncorhynchus kisutch diets were also tested over a 2-month feeding trial...
October 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28529818/high-protein-fish-oil-diet-prevents-hepatic-steatosis-in-noncnzo10-mice-association-with-diet-genetics-regulated-micro-rnas
#15
Nikhil Adi, Jennipher Adi, Roberta Marques Lassance-Soares, Paul Kurlansky, Hong Yu, Keith A Webster
OBJECTIVE: NONcNZO10 (NZ10) mice are predisposed to obesity and develop type 2 diabetes (T2D) and hepatic steatosis even when maintained on a control diet (CD) of 6% fat. Studies were designed to determine whether this extreme susceptibility phenotype could be alleviated by diet and if so the molecular targets of diet. METHODS: NZ10 and SWR/J (SWR) control mice were fed a CD or a test diet of high protein and fish oil (HPO) for 19 weeks and then analyzed for steatosis, blood chemistry, hepatic gene and micro-RNA expression...
June 2016: Journal of Diabetes & Metabolism
https://www.readbyqxmd.com/read/28404768/dj-1-overexpression-restores-ischaemic-post-conditioning-mediated-cardioprotection-in-diabetic-rats-role-of-autophagy
#16
Bin Zhou, Shaoqing Lei, Rui Xue, Yan Leng, Zhengyuan Xia, Zhong-Yuan Xia
IPO (ischaemic post-conditioning) is a promising method of alleviating myocardial IR (ischaemia-reperfusion) injury; however, IPO-mediated cardioprotection is lost in diabetic hearts via mechanisms that remain largely unclear. We hypothesized that decreased cardiac expression of DJ-1, a positive modulator of autophagy, compromises the effectiveness of IPO-induced cardioprotection in diabetic rats. Diabetic rats subjected to myocardial IR (30 min of coronary artery occlusion followed by 120 min of reperfusion) exhibited more severe myocardial injury, less cardiac autophagy, lower DJ-1 expression and AMPK (adenosine monophosphate-activated protein kinase)/mTOR (mammalian target of rapamycin) pathway activity than non-diabetic rats...
June 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28380545/roles-of-phosphoric-acid-in-biochar-formation-synchronously-improving-carbon-retention-and-sorption-capacity
#17
Ling Zhao, Wei Zheng, Ondřej Mašek, Xiang Chen, Bowen Gu, Brajendra K Sharma, Xinde Cao
Pretreatment of biomass with phosphoric acid (HPO) for biochar production was expected to improve carbon (C) retention, porosity structure, and the sorption ability of biochar. This study investigated the interaction of phosphorus with the C structure to elucidate the mechanisms by which HPO simultaneously captured C and created micropores. Sawdust was soaked in diluted HPO and dried for pyrolytic biochar generation at 350, 500, and 650°C. Results showed that HPO pretreatment resulted in 70 to 80% of biomass C retention in biochar, compared with only about 50% remaining without pretreatment...
March 2017: Journal of Environmental Quality
https://www.readbyqxmd.com/read/28363026/hydroxypyridinone-and-5-aminolaevulinic-acid-conjugates-for-photodynamic-therapy
#18
Sinan Battah, Robert C Hider, Alexander J MacRobert, Paul S Dobbin, Tao Zhou
Photodynamic therapy (PDT) is a promising treatment strategy for malignant and nonmalignant lesions. 5-Aminolaevulinic acid (ALA) is used as a precursor of the photosensitizer, protoporphyrin IX (PpIX), in dermatology and urology. However, the effectiveness of ALA-PDT is limited by the relatively poor bioavailability of ALA and rapid conversion of PpIX to haem. The main goal of this study was to prepare and investigate a library of single conjugates designed to coadminister the bioactive agents ALA and hydroxypyridinone (HPO) iron chelators...
April 27, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28336542/seten-a-tool-for-systematic-identification-and-comparison-of-processes-phenotypes-and-diseases-associated-with-rna-binding-proteins-from-condition-specific-clip-seq-profiles
#19
Gungor Budak, Rajneesh Srivastava, Sarath Chandra Janga
RNA-binding proteins (RBPs) control the regulation of gene expression in eukaryotic genomes at post-transcriptional level by binding to their cognate RNAs. Although several variants of CLIP (crosslinking and immunoprecipitation) protocols are currently available to study the global protein-RNA interaction landscape at single-nucleotide resolution in a cell, currently there are very few tools that can facilitate understanding and dissecting the functional associations of RBPs from the resulting binding maps...
June 2017: RNA
https://www.readbyqxmd.com/read/28321570/comparative-analysis-of-locking-plate-versus-hook-plate-osteosynthesis-of-neer-type-iib-lateral-clavicle-fractures
#20
Benjamin Erdle, Kaywan Izadpanah, Martin Jaeger, Patrizia Jensen, Lukas Konstantinidis, Jörn Zwingmann, Norbert P Südkamp, Dirk Maier
INTRODUCTION: Controversy exists on optimal operative treatment of vertically unstable Neer IIB lateral clavicle fractures. Aim of this study was to analyse and compare clinical and radiological results and complications of locking plate osteosynthesis (LPO) versus hook plate osteosynthesis (HPO) with acromioclavicular joint (ACJ) stabilization. The hypothesis was, that HPO would recreate coracoclavicular stability more effectively and potentially lead to a superior outcome. METHODS: This retrospective, observational cohort study included 32 patients (19 HPO, 13 LPO) with a mean age of 44...
May 2017: Archives of Orthopaedic and Trauma Surgery
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