keyword
MENU ▼
Read by QxMD icon Read
search

Hpo

keyword
https://www.readbyqxmd.com/read/29760010/home-oximetry-to-screen-for-obstructive-sleep-apnoea-in-down-syndrome
#1
Catherine M Hill, Heather E Elphick, Michael Farquhar, Paul Gringras, Ruth M Pickering, Ruth N Kingshott, Jane Martin, Janine Reynolds, Anna Joyce, Johanna C Gavlak, Hazel J Evans
OBJECTIVE: Children with Down syndrome are at high risk of obstructive sleep apnoea (OSA) and screening is recommended. Diagnosis of OSA should be confirmed with multichannel sleep studies. We aimed to determine whether home pulse oximetry (HPO) discriminates children at high risk of OSA, who need further diagnostic multichannel sleep studies. DESIGN: Cross-sectional prospective study in a training sample recruited through three UK centres. Validation sample used single-centre retrospective analysis of clinical data...
May 14, 2018: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29758261/annotating-diseases-using-human-phenotype-ontology-improves-prediction-of-disease-associated-long-non-coding-rnas
#2
Duc-Hau Le, Lan T M Dao
Recently, many long non-coding RNAs (lncRNAs) have been identified and their biological function has been characterized; however, our understanding of their underlying molecular mechanisms related to disease is still limited. To overcome the limitation in experimentally identifying disease-lncRNA associations, computational methods have been proposed as a powerful tool to predict such associations. These methods are usually based on the similarities between diseases or lncRNAs since it was reported that similar diseases are associated with functionally similar lncRNAs...
May 11, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29745853/a-new-method-to-measure-the-semantic-similarity-from-query-phenotypic-abnormalities-to-diseases-based-on-the-human-phenotype-ontology
#3
Xiaofeng Gong, Jianping Jiang, Zhongqu Duan, Hui Lu
BACKGROUND: Although rapid developed sequencing technologies make it possible for genotype data to be used in clinical diagnosis, it is still challenging for clinicians to understand the results of sequencing and make correct judgement based on them. Before this, diagnosis based on clinical features held a leading position. With the establishment of the Human Phenotype Ontology (HPO) and the enrichment of phenotype-disease annotations, there throws much more attention to the improvement of phenotype-based diagnosis...
May 8, 2018: BMC Bioinformatics
https://www.readbyqxmd.com/read/29743077/role-of-hormonal-and-inflammatory-alterations-in-obesity-related-reproductive-dysfunction-at-the-level-of-the-hypothalamic-pituitary-ovarian-axis
#4
REVIEW
Michelle Goldsammler, Zaher Merhi, Erkan Buyuk
BACKGROUND: Besides being a risk factor for multiple metabolic disorders, obesity could affect female reproduction. While increased adiposity is associated with hormonal changes that could disrupt the function of the hypothalamus and the pituitary, compelling data suggest that obesity-related hormonal and inflammatory changes could directly impact ovarian function. OBJECTIVE: To review the available data related to the mechanisms by which obesity, and its associated hormonal and inflammatory changes, could affect the female reproductive function with a focus on the hypothalamic-pituitary-ovarian (HPO) axis...
May 9, 2018: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/29742619/loss-of-function-mutation-in-hippo-suppressed-enlargement-of-lysosomes-and-neurodegeneration-caused-by-dfig4-knockdown
#5
Yukie Kushimura, Yumiko Azuma, Ikuko Mizuta, Yuuka Muraoka, Akane Kyotani, Hideki Yoshida, Takahiko Tokuda, Toshiki Mizuno, Masamitsu Yamaguchi
Charcot-Marie-Tooth disease (CMT) is the most common hereditary neuropathy, and more than 80 CMT-causing genes have been identified to date. CMT4J is caused by a loss-of-function mutation in the Factor-Induced-Gene 4 (FIG4) gene, the product of which plays important roles in endosome-lysosome homeostasis. We hypothesized that Mammalian sterile 20-like kinase (MST) 1 and 2, tumor-suppressor genes, are candidate modifiers of CMT4J. We therefore examined the interaction between dFIG4 and Hippo (hpo), Drosophila counterparts of FIG4 and MSTs, respectively, using the Drosophila CMT4J model with the knockdown of dFIG4...
May 8, 2018: Neuroreport
https://www.readbyqxmd.com/read/29738713/a-dendritic-guidance-receptor-complex-brings-together-distinct-actin-regulators-to-drive-efficient-f-actin-assembly-and-branching
#6
Wei Zou, Xintong Dong, Timothy R Broederdorf, Ao Shen, Daniel A Kramer, Rebecca Shi, Xing Liang, David M Miller, Yang K Xiang, Ryohei Yasuda, Baoyu Chen, Kang Shen
Proper morphogenesis of dendrites plays a fundamental role in the establishment of neural circuits. The molecular mechanism by which dendrites grow highly complex branches is not well understood. Here, using the Caenorhabditis elegans PVD neuron, we demonstrate that high-order dendritic branching requires actin polymerization driven by coordinated interactions between two membrane proteins, DMA-1 and HPO-30, with their cytoplasmic interactors, the RacGEF TIAM-1 and the actin nucleation promotion factor WAVE regulatory complex (WRC)...
May 7, 2018: Developmental Cell
https://www.readbyqxmd.com/read/29695716/regulation-of-yki-yap-subcellular-localization-and-hpo-signaling-by-a-nuclear-kinase-prp4k
#7
Yong Suk Cho, Jian Zhu, Shuangxi Li, Bing Wang, Yuhong Han, Jin Jiang
Hippo (Hpo) signaling pathway controls tissue growth by regulating the subcellular localization of Yorkie (Yki)/Yap via a cytoplasmic kinase cassette containing an upstream kinase Hpo/MST1/2 and a downstream kinase Warts (Wts)/Lats1/2. Here we show that PRP4K, a kinase involved in mRNA splicing, phosphorylates Yki/Yap in the nucleus to prevent its nuclear accumulation and restrict Hpo pathway target gene expression. PRP4K inactivation accelerates whereas excessive PRP4K inhibits Yki-driven tissue overgrowth...
April 25, 2018: Nature Communications
https://www.readbyqxmd.com/read/29693627/effect-of-silver-nitrate-and-sodium-fluoride-with-tri-calcium-phosphate-on-streptococcus-mutans-and-demineralised-dentine
#8
Ollie Yiru Yu, Irene Shuping Zhao, May Lei Mei, Edward Chin-Man Lo, Chun-Hung Chu
This study investigated the effect of 25% silver nitrate (AgNO₃) and 5% sodium fluoride (NaF) varnish with functionalized tri-calcium phosphate (fTCP) on a Streptococcus mutans ( S. mutans ) biofilm and dentine caries lesion. Demineralised dentine specimens were treated with 25% AgNO₃ and 5% NaF + fTCP (Group 1), 25% AgNO₃ and 5% NaF (Group 2), 25% AgNO₃ (Group 3), or water (Group 4). The specimens were subjected to a S. mutans biofilm challenge after treatment. The biofilm was then studied via scanning electron microscopy (SEM), confocal laser scanning microscopy (CLSM), and colony forming units (CFU)...
April 25, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29691674/environmental-control-of-vanadium-haloperoxidases-and-halocarbon-emissions-in-macroalgae
#9
REVIEW
Thillai Punitha, Siew-Moi Phang, Joon Ching Juan, John Beardall
Vanadium-dependent haloperoxidases (V-HPO), able to catalyze the reaction of halide ions (Cl- , Br- , I- ) with hydrogen peroxide, have a great influence on the production of halocarbons, which in turn are involved in atmospheric ozone destruction and global warming. The production of these haloperoxidases in macroalgae is influenced by changes in the surrounding environment. The first reported vanadium bromoperoxidase was discovered 40 years ago in the brown alga Ascophyllum nodosum. Since that discovery, more studies have been conducted on the structure and mechanism of the enzyme, mainly focused on three types of V-HPO, the chloro- and bromoperoxidases and, more recently, the iodoperoxidase...
April 24, 2018: Marine Biotechnology
https://www.readbyqxmd.com/read/29656043/pituitary-estrogen-receptor-alpha-is-involved-in-luteinizing-hormone-pulsatility-at-mid-gestation-in-the-south-american-plains-vizcacha-lagostomus-maximus-rodentia-caviomorpha
#10
Sofía Proietto, Lorena Yankelevich, Federico Martín Villarreal, Pablo Ignacio Felipe Inserra, Santiago Elías Charif, Alejandro Raúl Schmidt, Santiago Andrés Cortasa, María Clara Corso, Noelia Paula Di Giorgio, Victoria Lux-Lantos, Alfredo Daniel Vitullo, Julia Halperin, Verónica Berta Dorfman
The South American plains vizcacha, Lagostomus maximus, is a caviomorph rodent native from Argentina, Bolivia and Paraguay. It shows peculiar reproductive features like pre-ovulatory follicle recruitment during pregnancy with an ovulatory process at around mid-gestation. We have described the activation of the hypothalamic - pituitary - ovarian (HPO) axis during pregnancy. A progressive decrease of progesterone (P4) at mid-pregnancy elicits the delivery of gonadotropin-releasing hormone (GnRH) with the consequent secretion of follicle stimulating hormone (FSH) and estradiol (E2 ) followed by luteinizing hormone (LH) release resulting in follicular luteinization and the P4 concentration recover...
April 12, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29606751/effects-of-packaging-and-pre-storage-treatments-on-aflatoxin-production-in-peanut-storage-under-controlled-conditions
#11
Clara Darko, Parameswaran Kumar Mallikarjunan, Hande Kaya-Celiker, Emmanuel Anokye Frimpong, Komla Dizisi
This study reports on aflatoxin production and peanut (Bailey's variety) quality, for four peanut pre-storage treatments; [(Raw clean (Raw-Cl), Raw inoculated with Aspergillus flavus NRRL 3357 (Raw-Inf), inoculated partially roasted but not-blanched (PRN-blanch); and inoculated partially roasted, blanched with discolored nuts sorted out (PR-blanched)]. All four treated samples were packaged in four different packaging systems [polypropylene woven sacks (PS), hermetic packs (HP), hermetic packs with oxygen absorbers (HPO), and vacuumed hermetic packs (HPV)] and stored under controlled conditions at a temperature of 30 ± 1 °C and water activity of 0...
April 2018: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29548405/carbonaceous-and-nitrogenous-disinfection-byproduct-precursor-variation-during-the-reversed-anaerobic-anoxic-oxic-process-of-a-sewage-treatment-plant
#12
Huihui Han, Hengfeng Miao, Yajing Zhang, Minfeng Lu, Zhenxing Huang, Wenquan Ruan
Disinfection byproduct (DBP) precursors in wastewater during the reversed anaerobic-anoxic-oxic (A2 /O) process, as well as their molecular weight (MW) and polarity-based fractions, were characterized with UV scanning, fluorescence excitation emission matrix, Fourier transform infrared and nuclear magnetic resonance spectroscopy. Their DBP formation potentials (DBPFPs) after chlorination were further tested. Results indicated that the reversed A2 /O process could not only effectively remove the dissolved organic carbon (DOC) and dissolved total nitrogen in the wastewater, but also affect the MW distribution and hydrophilic-hydrophobic properties of dissolved organic matter (DOM)...
March 2018: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/29524817/further-insight-into-the-roles-of-the-chemical-composition-of-dissolved-organic-matter-dom-on-ultrafiltration-membranes-as-revealed-by-multiple-advanced-dom-characterization-tools
#13
Quang Viet Ly, Jin Hur
This study assessed the relative contributions of different constitutes in dissolved organic matter (DOM) with two different sources (i.e., urban river and effluent) to membrane fouling on three types of ultrafiltration (UF) membranes via excitation emission matrix - parallel factor analysis (EEM-PARAFAC), size exclusion chromatography (SEC), and Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR-MS). Two polyethersulfone membranes with different pore sizes and one regenerated cellulose membrane were used as representative hydrophobic (HPO) and hydrophilic (HPI) UF membranes, respectively...
June 2018: Chemosphere
https://www.readbyqxmd.com/read/29517769/toward-an-effective-exome-based-genetic-testing-strategy-in-pediatric-dilated-cardiomyopathy
#14
Johanna C Herkert, Kristin M Abbott, Erwin Birnie, Martine T Meems-Veldhuis, Ludolf G Boven, Marloes Benjamins, Gideon J du Marchie Sarvaas, Daniela Q C M Barge-Schaapveld, J Peter van Tintelen, Paul A van der Zwaag, Yvonne J Vos, Richard J Sinke, Maarten P van den Berg, Irene M van Langen, Jan D H Jongbloed
PurposeWe evaluated the diagnostic yield in pediatric dilated cardiomyopathy (DCM) of combining exome sequencing (ES)-based targeted analysis and genome-wide copy-number variation (CNV) analysis. Based on our findings, we retrospectively designed an effective approach for genetic testing in pediatric DCM.MethodsWe identified 95 patients (in 85 families) with pediatric onset of DCM. We initially excluded 13 of these families because they already had a genetic diagnosis, leaving a total of 31 probands for single-nucleotide polymorphism (SNP) array and trio-ES...
March 8, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29466741/rap1-negatively-regulates-the-hippo-pathway-to-polarize-directional-protrusions-in-collective-cell-migration
#15
Yu-Chiuan Chang, Jhen-Wei Wu, Yi-Chi Hsieh, Tzu-Han Huang, Zih-Min Liao, Yi-Shan Huang, James A Mondo, Denise Montell, Anna C-C Jang
In collective cell migration, directional protrusions orient cells in response to external cues, which requires coordinated polarity among the migrating cohort. However, the molecular mechanism has not been well defined. Drosophila border cells (BCs) migrate collectively and invade via the confined space between nurse cells, offering an in vivo model to examine how group polarity is organized. Here, we show that the front/back polarity of BCs requires Rap1, hyperactivation of which disrupts cluster polarity and induces misoriented protrusions and loss of asymmetry in the actin network...
February 20, 2018: Cell Reports
https://www.readbyqxmd.com/read/29457552/reciprocal-regulation-of-yap-taz-by-the-hippo-pathway-and-the-small-gtpase-pathway
#16
Ju-Won Jang, Min-Kyu Kim, Suk-Chul Bae
Yes-associated protein 1 (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) (YAP/TAZ) are transcriptional coactivators that regulate genes involved in proliferation and transformation by interacting with DNA-binding transcription factors. Remarkably, YAP/TAZ are essential for cancer initiation or growth of most solid tumors. Their activation induces cancer stem cell attributes, proliferation, and metastasis. The oncogenic activity of YAP/TAZ is inhibited by the Hippo cascade, an evolutionarily conserved pathway that is governed by two kinases, mammalian Ste20-like kinases 1/2 (MST1/2) and Large tumor suppressor kinase 1/2 (LATS1/2), corresponding to Drosophila's Hippo (Hpo) and Warts (Wts), respectively...
April 20, 2018: Small GTPases
https://www.readbyqxmd.com/read/29452392/pbrit-gene-prioritization-by-correlating-functional-and-phenotypic-annotations-through-integrative-data-fusion
#17
Ajay Anand Kumar, Lut Van Laer, Maaike Alaerts, Amin Ardeshirdavani, Yves Moreau, Kris Laukens, Bart Loeys, Geert Vandeweyer
Motivation: Computational gene prioritization can aid in disease gene identification. Here, we propose pBRIT (prioritization using Bayesian Ridge regression and Information Theoretic model), a novel adaptive and scalable prioritization tool, integrating Pubmed abstracts, Gene Ontology, Sequence similarities, Mammalian and Human Phenotype Ontology, Pathway, Interactions, Disease Ontology, Gene Association database and Human Genome Epidemiology database, into the prediction model.We explore and address effects of sparsity and inter-feature dependencies within annotation sources, and the impact of bias towards specific annotations...
February 14, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29452184/production-of-chitinase-from-escherichia-fergusonii-chitosanase-from-chryseobacterium-indologenes-comamonas-koreensis-and-its-application-in-n-acetylglucosamine-production
#18
Tae Il Kim, Dong Hyun Lim, Kwang Soo Baek, Sun Sik Jang, Beom Young Park, Vijayakumar Mayakrishnan
The important platform polysaccharide N-acetylglucosamine (GlcNAc) has great potential to be used in the fields of food, cosmetics, agricultural, pharmaceutical, medicine and biotechnology. This GlcNAc is being produced by traditional methods of environment-unfriendly chemical digestion with strong acids. Therefore, researchers have been paying more attention to enzymatic hydrolysis process for the production of GlcNAc. Hence, in this study, we isolated novel chitinase (Escherichia fergusonii) and chitosanase (Chryseobacterium indologenes, Comamonas koreensis) producing strains from Korean native calves feces, and developed the potential of an eco-friendly microbial progression for GlcNAc production from swollen chitin and chitosan by enzymatic degradation...
June 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29448712/a-simulated-body-fluid-evaluation-of-tio%C3%A2-barrier-oxide-layer-formed-by-electrochemical-reaction
#19
Jae-Myung Jang, Tae-Eon Park, Seung-Dai Kim, Han-Cheol Choe
The modified surface during implantation is considered to be an effective strategy to improve high adhesion of bone cell and osseointegration activity. In this paper, the TiO2 barrier oxide Layer has been fabricated by using the ion characteristic of an electrolytic solution, the surface characteristics have been investigated by EDS, XPS, and FE-SEM. From the analysis of the chemical states, phosphorus and calcium were observed in the TiO2 barrier layer, which were penetrated from the electrolyte into the oxide layer during deposit process...
March 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29425702/harmonising-phenomics-information-for-a-better-interoperability-in-the-rare-disease-field
#20
REVIEW
Sylvie Maiella, Annie Olry, Marc Hanauer, Valérie Lanneau, Halima Lourghi, Bruno Donadille, Charlotte Rodwell, Sebastian Köhler, Dominik Seelow, Simon Jupp, Helen Parkinson, Tudor Groza, Michael Brudno, Peter N Robinson, Ana Rath
HIPBI-RD (Harmonising phenomics information for a better interoperability in the rare disease field) is a three-year project which started in 2016 funded via the E-Rare 3 ERA-NET program. This project builds on three resources largely adopted by the rare disease (RD) community: Orphanet, its ontology ORDO (the Orphanet Rare Disease Ontology), HPO (the Human Phenotype Ontology) as well as PhenoTips software for the capture and sharing of structured phenotypic data for RD patients. Our project is further supported by resources developed by the European Bioinformatics Institute and the Garvan Institute...
February 7, 2018: European Journal of Medical Genetics
keyword
keyword
102333
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"