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https://www.readbyqxmd.com/read/29125115/roles-of-hypothalamic-pituitary-adrenal-axis-and-hypothalamus-pituitary-ovary-axis-in-the-abnormal-endocrine-functions-in-patients-with-polycystic-ovary-syndrome
#1
Fan Wang, Zheng-Hong Zhang, Kai-Zhuan Xiao, Zheng-Chao Wang
Polycystic ovary syndrome(PCOS) is a common reproductive endocrine disease in women of childbearing age. While it can be affected by a variety of factors,its pathophysiology remains unclear. Its clinical features mainly include anovulation,hyperandrogenism,and hyperinsulinemia,which are closely related with abnormal neuroendocrine system. Hypothalamic-pituitary-gonadal axis(HPG) plays a crucial regulatory role in various life activities in mammals. In particular,hypothalamic-pituitary-adrenal(HPA) axis and hypothalamus-pituitary-ovary(HPO) axis can be abnormal in PCOS patients...
October 30, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/29077208/clinical-efficacy-of-a-next-generation-sequencing-gene-panel-for-primary-immunodeficiency-diagnostics
#2
W Rae, D Ward, C Mattocks, R J Pengelly, E Eren, S V Patel, S N Faust, D Hunt, A P Williams
Primary immunodeficiencies (PIDs) are rare monogenic inborn errors of immunity that result in impairment of functions of the human immune system. PIDs have a broad phenotype with increased morbidity and mortality and treatment choices are often complex. With increased accessibility of next-generation sequencing the rate of discovery of genetic causes for PID has increased exponentially. Identification of an underlying monogenic diagnosis provides important clinical benefits for patients with the potential to alter treatments, facilitate genetic counselling, and pre-implantation diagnostics...
October 27, 2017: Clinical Genetics
https://www.readbyqxmd.com/read/29071997/-effect-of-electroacupuncture-on-hypothalamus-pituitary-ovary-hpo-axis-in-rats-with-peri-menopausal-depression
#3
Xi-Rong Jiang, Lu Ren, Chun-Ri Li
OBJECTIVE: To observe the effect of electroacupuncture (EA) on the hormones derived from the hypothalamus-pituitary-ovary (HPO) axis, so as to explore the neuroendocrine mechanism induced by EA on rats with perimenopausal depression disorder. METHODS: Sixty female sprague-dawley rats were randomly divided into blank control group, model group, sham-operation (sham) group, clomipramine group, and electroacupuncture (EA) group, with 12 rats in each group. Perimenopausal depression model was established by bilateral ovariectomy combined with chronic unpredictable stimulation...
February 25, 2017: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29063556/knowledge-representation-and-management-it-s-time-to-integrate
#4
F Dhombres, J Charlet
Objectives: To select, present, and summarize the best papers published in 2016 in the field of Knowledge Representation and Management (KRM). Methods: A comprehensive and standardized review of the medical informatics literature was performed based on a PubMed query. Results: Among the 1,421 retrieved papers, the review process resulted in the selection of four best papers focused on the integration of heterogeneous data via the development and the alignment of terminological resources. In the first article, the authors provide a curated and standardized version of the publicly available US FDA Adverse Event Reporting System...
August 2017: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/29031632/separate-transcriptionally-regulated-pathways-specify-distinct-classes-of-sister-dendrites-in-a-nociceptive-neuron
#5
Barbara M J O'Brien, Sierra D Palumbos, Michaela Novakovic, Xueying Shang, Lakshmi Sundararajan, David M Miller
The dendritic processes of nociceptive neurons transduce external signals into neurochemical cues that alert the organism to potentially damaging stimuli. The receptive field for each sensory neuron is defined by its dendritic arbor, but the mechanisms that shape dendritic architecture are incompletely understood. Using the model nociceptor, the PVD neuron in C. elegans, we determined that two types of PVD lateral branches project along the dorsal/ventral axis to generate the PVD dendritic arbor: (1) Pioneer dendrites that adhere to the epidermis, and (2) Commissural dendrites that fasciculate with circumferential motor neuron processes...
October 13, 2017: Developmental Biology
https://www.readbyqxmd.com/read/29025394/prediction-of-human-phenotype-ontology-terms-by-means-of-hierarchical-ensemble-methods
#6
Marco Notaro, Max Schubach, Peter N Robinson, Giorgio Valentini
BACKGROUND: The prediction of human gene-abnormal phenotype associations is a fundamental step toward the discovery of novel genes associated with human disorders, especially when no genes are known to be associated with a specific disease. In this context the Human Phenotype Ontology (HPO) provides a standard categorization of the abnormalities associated with human diseases. While the problem of the prediction of gene-disease associations has been widely investigated, the related problem of gene-phenotypic feature (i...
October 12, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/29017443/a-new-synonym-substitution-method-to-enrich-the-human-phenotype-ontology
#7
Maria Taboada, Hadriana Rodriguez, Ranga C Gudivada, Diego Martinez
BACKGROUND: Named entity recognition is critical for biomedical text mining, where it is not unusual to find entities labeled by a wide range of different terms. Nowadays, ontologies are one of the crucial enabling technologies in bioinformatics, providing resources for improved natural language processing tasks. However, biomedical ontology-based named entity recognition continues to be a major research problem. RESULTS: This paper presents an automated synonym-substitution method to enrich the Human Phenotype Ontology (HPO) with new synonyms...
October 10, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28993190/secretome-from-hypoxia-conditioned-adipose-derived-mesenchymal-stem-cells-promotes-the-healing-of-gastric-mucosal-injury-in-a-rodent-model
#8
Xianfeng Xia, Philip Wai Yan Chiu, Ping Kuen Lam, Wai Ching Chin, Enders Kwok Wai Ng, James Yun Wong Lau
Studies have indicated that the definitive engraftment and transdifferentiation potential of stem cells do not seem crucial for its property of tissue repair. Our previous study showed that transplantation of adipose-derived mesenchymal stem cells (ADMSCs) enhanced the healing of sutured gastric perforation. This study aimed to investigate the paracrine role of ADMSCs in the experimental gastric mucosal injury. Normoxia-conditioned medium (Nor CM) and hypoxia (HPO) CM were obtained after culturing ADMSCs in 20% O2 and 5% O2 for 48h...
October 6, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28991988/citrate-addition-increased-phosphorus-bioavailability-and-enhanced-gasoline-bioremediation
#9
Tingting Chen, Courtney Philips, Jordan Hamilton, Blaine Chartbrand, Jay Grosskleg, Kris Bradshaw, Trevor Carlson, Karen Timlick, Derek Peak, Steven D Siciliano
Phosphorus (P) bioavailability often limits gasoline biodegradation in calcareous cold-region soils. One possible method to increase P bioavailability in such soils is the addition of citrate. Citrate addition at the field scale may increase hydrocarbon degradation by: (i) enhancing inorganic and organic P dissolution and desorption, (ii) increasing hydrocarbon bioavailability, and/or (iii) stimulating microbial activity. Alternatively, citrate addition may inhibit activity due to competitive effects on carbon metabolism...
September 2017: Journal of Environmental Quality
https://www.readbyqxmd.com/read/28946786/preaxial-polydactyly-of-the-foot
#10
Elise B Burger, Martijn Baas, Steven E R Hovius, A Jeannette M Hoogeboom, Christianne A van Nieuwenhoven
Background and purpose - Preaxial polydactyly of the foot is a rare malformation and clinicians are often unfamiliar with the associated malformations and syndromes. In order to give guidelines for diagnostics and referral to a clinical geneticist, we provide an overview of the presentation using a literature review and our own patient population. Patients and methods - The literature review was based on the Human Phenotype Ontology (HPO) project. From the HPO dataset, all phenotypes describing preaxial polydactyly were obtained and related diseases were identified and selected...
September 26, 2017: Acta Orthopaedica
https://www.readbyqxmd.com/read/28937253/sirt1-mediates-improvement-in-cognitive-defects-induced-by-focal-cerebral-ischemia-following-hyperbaric-oxygen-preconditioning-in-rats
#11
P Ding, D Ren, S He, M He, G Zhang, Y Chen, H Sang, Z Peng, W Yan
Hyperbaric oxygen preconditioning (HBO-PC) has been proposed as a safe and practical approach for neuroprotection in ischemic stroke. However, it is not known whether HPO-PC can improve cognitive deficits induced by cerebral ischemia, and the mechanistic basis for any beneficial effects remains unclear. We addressed this in the present study using rats subjected to middle cerebral artery occlusion (MCAO) as an ischemic stroke model following HBO-PC. Cognitive function and expression of phosphorylated neurofilament heavy polypeptide (pNF-H) and doublecortin (DCX) in the hippocampus were evaluated 14 days after reperfusion and after short interfering RNA-mediated knockdown of sirtuin1 (Sirt1)...
September 22, 2017: Physiological Research
https://www.readbyqxmd.com/read/28910478/a-shift-from-resilience-to-human-performance-optimization-in-special-operations-training-advancements-in-theory-and-practice
#12
Gloria H Park, Lauren A Messina, Patricia A Deuster
Within the Department of Defense over the past decade, a focus on enhancing Warfighter resilience and readiness has increased. For Special Operation Forces (SOF), who bear unique burdens for training and deployment, programs like the Preservation of the Force and Family have been created to help support SOF and their family members in sustaining capabilities and enhancing resilience in the face of prolonged warfare. In this review, we describe the shift in focus from resilience to human performance optimization (HPO) and the benefits of human performance initiatives that include holistic fitness...
2017: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
https://www.readbyqxmd.com/read/28796921/transition-metal-titanophosphates-with-intercalated-molecular-photoluminescence-and-catalytic-properties
#13
Ling-I Hung, Pei-Lin Chen, Jia-Hao Yang, Chi-How Peng, Sue-Lein Wang
In this study, α-TiP layered structure incorporating a heterometal center for organic ligand binding to enhance structural complexity and functionality were prepared. The protons of the α-TiP layer were replaced with zinc ions coordinated by 4-pyridinecarboxylic acid (PCA) and water to form a layer structure, TiZn(PO4 )2 (H2 O)(PCA) (1). The tetrahedral zinc center with coordinated water in 1 is unprecedented in zincophosphate or zinc-MOF systems and is usually only found in metalloenzyme systems. The neutral zincotitanophosphate layers, tightly stacked through hydrogen bonds, showed velcro-like behavior on intercalating 4,4'-trimethylenedipyridine (TMDP) reversibly...
August 10, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28793345/cloning-and-expression-analysis-of-bmyki-gene-in-silkworm-bombyx-mori
#14
Wenhui Zeng, Riyuan Wang, Tianyang Zhang, Chunying Gong, Weidong Zuo, Rongpeng Liu, Yao Ou, Hanfu Xu
The transcriptional coactivator Yorkie(Yki), is a critical downstream effector of the Hippo(Hpo) signaling pathway that controls organ size through the regulation of cell proliferation and apoptosis. During the past ten years the biological function of Yki has been studied extensively in Drosophila and a few other insects, however, little is known about it in the silkworm, Bombyx mori, a major research model of lepidopteran insect. Here, we describe the isolation, characterization and expression of the B. mori Yki ortholog, BmYki...
2017: PloS One
https://www.readbyqxmd.com/read/28774602/chloramination-of-wastewater-effluent-toxicity-and-formation-of-disinfection-byproducts
#15
Julien Le Roux, Michael J Plewa, Elizabeth D Wagner, Maolida Nihemaiti, Azra Dad, Jean-Philippe Croué
The reclamation and disinfection of waters impacted by human activities (e.g., wastewater effluent discharges) are of growing interest for various applications but has been associated with the formation of toxic nitrogenous disinfection byproducts (N-DBPs). Monochloramine used as an alternative disinfectant to chlorine can be an additional source of nitrogen in the formation of N-DBPs. Individual toxicity assays have been performed on many DBPs, but few studies have been conducted with complex mixtures such as wastewater effluents...
August 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28765969/ampk-activation-restores-ischemic-post%C3%A2-conditioning-cardioprotection-in-stz%C3%A2-induced-type-1-diabetic-rats-role-of-autophagy
#16
Bin Zhou, Yan Leng, Shao-Qing Lei, Zhong-Yuan Xia
Although the mechanism remains unclear, ischemic post‑conditioning (IPO) is a promising approach to combat myocardial ischemia reperfusion (IR) injury; however, it has been proven ineffective in diabetes. The present study aimed to identify whether hyperglycemia‑induced AMP‑activated protein kinase (AMPK) inhibition contributes to the ineffectiveness of IPO via autophagy attenuation in diabetic hearts. Diabetic and non‑diabetic rats were subjected to myocardial IR and/or IPO with/without treatment with the AMPK activator A‑769662 and/or autophagy inhibitor 3‑methyladenine (3‑MA)...
September 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28689652/field-evaluation-of-candidate-baits-for-oral-delivery-of-bcg-vaccine-to-european-badgers-meles-meles
#17
Kate Palphramand, Richard Delahay, Andrew Robertson, Sonya Gowtage, Gareth A Williams, Robbie A McDonald, Mark Chambers, Stephen P Carter
The control of tuberculosis (TB) in cattle in the UK and Ireland is compromised by transmission of Mycobacterium bovis to cattle from the European badger (Meles meles), which acts as a wildlife reservoir. Vaccination of badgers could potentially contribute to TB control but the only licensed vaccine is injectable BadgerBCG which requires the live-capture of badgers. Current research is aimed at developing an oral TB vaccine (where vaccine is contained within bait) that is intended to be more cost-effective to deploy over large areas...
July 6, 2017: Vaccine
https://www.readbyqxmd.com/read/28669419/identification-of-associated-genes-and-diseases-in-patients-with-congenital-upper-limb-anomalies-a-novel-application-of-the-omt-classification
#18
Martijn Baas, Andrew P Stubbs, David B van Zessen, Robert-Jan H Galjaard, Peter J van der Spek, Steven E R Hovius, Christianne A van Nieuwenhoven
PURPOSE: Congenital upper-limb anomalies (CULA) can present as a part of a syndrome or association. There is a wide spectrum of CULA, each of which might be related to different diseases. The structure provided by the Oberg, Manske, and Tonkin (OMT) classification could aid in differential diagnosis formulation in patients with CULA. The aims of this study were to review the Human Phenotype Ontology (HPO) project database for diseases and causative genes related to the CULA described in the OMT classification and to develop a methodology for differential diagnosis formulation based on the observed congenital anomalies, CulaPhen...
July 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28667262/the-hippo-pathway-acts-downstream-of-the-hedgehog-signaling-to-regulate-follicle-stem-cell-maintenance-in-the-drosophila-ovary
#19
Ta-Hsing Hsu, Chia-Yu Yang, Tsung-Han Yeh, Yi-Chia Huang, Tsu-Wei Wang, Jenn-Yah Yu
The Hippo pathway is conserved and plays important roles in organ size control. The core components of the Hippo pathway are two kinases Hippo (Hpo), Warts (Wts), and a transcription-co-activator Yorkie (Yki). Yki activity is regulated by phosphorylation, which affects its nuclear localization and stability. To determine the role of the Hippo pathway in stem cells, we examine follicle stem cells (FSCs) in the Drosophila ovary. Yki is detected in the nucleus of FSCs. Knockdown of yki in the follicle cell lineage leads to a disruption of the follicular epithelium...
June 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28665539/minimalistic-liquid-assisted-route-to-highly-crystalline-%C3%AE-zirconium-phosphate
#20
Yu Cheng, Xiaodong Tony Wang, Stephan Jaenicke, Gaik-Khuan Chuah
Zirconium phosphates have potential applications in areas of ion exchange, catalysis, photochemistry, and biotechnology. However, synthesis methodologies to form crystalline α-zirconium phosphate (Zr(HPO4 )2 ⋅H2 O) typically involve the use of excess phosphoric acid, addition of HF or oxalic acid and long reflux times or hydrothermal conditions. A minimalistic sustainable route to its synthesis has been developed by using only zirconium oxychloride and concentrated phosphoric acid to form highly crystalline α-zirconium phosphate within hours...
August 24, 2017: ChemSusChem
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