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L Xiao, Y Wei, Y-N Zhang, X Luo, B-Y Yang, S-F Yu, X-M Wu, C-Y Wu, H-B Li
BACKGROUND: IL-21 is a key cytokine for regulating B cell immunity, which is involved in several inflammatory conditions. This study sought to define a role for IL-21 in activated B lymphocytes and enhanced tissue eosinophilia in NP tissues during the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP). METHODS: NP and uncinate process tissues were collected from 64 CRSwNP patients, 25 CRSsNP patients, and 29 control subjects. IL-21 expression was examined using IHC staining, qRT-PCR, flow cytometry, and ELISA, and its clinical implication was evaluated...
February 2015: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
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