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https://www.readbyqxmd.com/read/29224579/wilder-penfield-sir-arthur-currie-and-the-montreal-neurological-institute
#1
R Mark Sadler
Wilder Penfield and the Montreal Neurological Institute (MNI) are inextricably linked. It was Penfield's unique idea to create a building with an academic atmosphere wherein basic neuroscience and clinical care of neurological patients would benefit from interaction and mutual support. It is clear that without Penfield that there would be no MNI; however, the role of another Canadian icon, Sir Arthur Currie, in the development of the MNI has heretofore been barely mentioned. The thesis of this paper is that Currie had a critical role in the gestation of the MNI that has generally been ignored...
December 11, 2017: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/29210936/optical-coherence-tomography-and-histology-of-age-related-macular-degeneration-support-mitochondria-as-reflectivity-sources
#2
Katie M Litts, Yuhua Zhang, K Bailey Freund, Christine A Curcio
PURPOSE: Widespread adoption of optical coherence tomography has revolutionized the diagnosis and management of retinal disease. If the cellular and subcellular sources of reflectivity in optical coherence tomography can be identified, the value of this technology will be advanced even further toward precision medicine, mechanistic thinking, and molecular discovery. Four hyperreflective outer retinal bands are created by the exquisite arrangement of photoreceptors, Müller cells, retinal pigment epithelium, and Bruch membrane...
November 23, 2017: Retina
https://www.readbyqxmd.com/read/29206132/effect-of-grazing-behavior-on-weight-regain-post-bariatric-surgery-a-systematic-review
#3
REVIEW
Nathalia Pizato, Patrícia B Botelho, Vivian S S Gonçalves, Eliane S Dutra, Kênia M B de Carvalho
Grazing, a type of maladaptive eating behavior, has been associated with poor weight outcomes in bariatric patients. The purpose of this study was to conduct a systematic review of the association between grazing behavior and weight regain post-bariatric surgery. Literature searches, study selection, design of the method, and quality appraisal were carried out by two independent authors. The search strategy was performed until October 2017 in Medline, Embase, Cochrane, Lilacs, Scopus, Web of Science, Google Scholar, ProQuest Dissertation & Theses, and Open Grey...
December 5, 2017: Nutrients
https://www.readbyqxmd.com/read/29199541/impact-of-temperature-on-the-narcotrend-index-during-hypothermic-cardiopulmonary-bypass-in-children-with-sevoflurane-anesthesia
#4
Nils Dennhardt, Christiane Beck, Dietmar Boethig, Sebastian Heiderich, Alexander Horke, Sebastian Tiedge, Martin Boehne, Robert Sümpelmann
BACKGROUND: During cardiopulmonary bypass (CPB) in children, anesthesia maintained by sevoflurane administered via the oxygenator is increasingly common. Anesthetic uptake and requirement may be influenced by the non-physiological conditions during hypothermic CPB. Narcotrend-processed EEG monitoring may, therefore, be useful to guide the administration of sevoflurane during this phase. OBJECTIVE: The objective of this prospective, clinical, observational study was to assess the correlation between body temperature, Narcotrend Index (NI) and administered sevoflurane in children during CPB...
December 1, 2017: Perfusion
https://www.readbyqxmd.com/read/29198378/fantastic-beasts-and-how-to-sequence-them-ecological-genomics-for-obscure-model-organisms
#5
REVIEW
Mikhail V Matz
The application of genomic approaches to 'obscure model organisms' (OMOs), meaning species with no prior genomic resources, enables increasingly sophisticated studies of the genomic basis of evolution, acclimatization, and adaptation in real ecological contexts. I consider here ecological questions that can be addressed using OMOs, and indicate optimal sequencing and data-handling solutions for each case. With this I hope to promote the diversity of OMO-based projects that would capitalize on the peculiarities of the natural history of OMOs and could feasibly be completed within the scope of a single PhD thesis...
November 29, 2017: Trends in Genetics: TIG
https://www.readbyqxmd.com/read/29196473/cell-scientist-to-watch-lukas-kapitein
#6
(no author information available yet)
Lukas Kapitein studied physics at the VU University in Amsterdam and graduated with a master's degree in experimental physics. He went on to do his PhD in the research groups of Christoph Schmidt and Erwin Peterman on the motility of mitotic kinesins, and in 2007, he won the biannual best thesis award from the Dutch society for Biophysics and Biomedical Technology. Lukas then joined the laboratory of Casper Hoogenraad at the Erasmus Medical Center in Rotterdam to work on the cytoskeleton and polarised cargo transport in neurons...
December 1, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/29193934/-about-the-thesis-of-specialization-in-medicine
#7
Roberto Rodríguez-García
No Abstract.
September 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29186473/meta-analysis-of-thirty-two-case-control-and-two-ecological-radon-studies-of-lung-cancer
#8
Ludwik Dobrzynski, Krzysztof W Fornalski, Joanna Reszczynska
A re-analysis has been carried out of thirty-two case-control and two ecological studies concerning the influence of radon, a radioactive gas, on the risk of lung cancer. Three mathematically simplest dose-response relationships (models) were tested: constant (zero health effect), linear, and parabolic (linear-quadratic). Health effect end-points reported in the analysed studies are odds ratios or relative risk ratios, related either to morbidity or mortality. In our preliminary analysis, we show that the results of dose-response fitting are qualitatively (within uncertainties, given as error bars) the same, whichever of these health effect end-points are applied...
November 23, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/29183795/from-zebrafish-to-human-a-comparative-approach-to-elucidate-the-role-of-the-thyroid-hormone-transporter-mct8-during-brain-development
#9
REVIEW
Pieter Vancamp, Veerle M Darras
Monocarboxylate transporter 8 (MCT8) facilitates transmembrane transport of thyroid hormones (THs) ensuring their action on gene expression during vertebrate neurodevelopment. A loss of MCT8 in humans results in severe psychomotor deficits associated with the Allan-Herndon-Dudley Syndrome (AHDS). However, where and when exactly a lack of MCT8 causes the neurological manifestations remains unclear because of the varying expression pattern of MCT8 between specific brain regions and cells. Here, we elaborate on the animal models that have been generated to elucidate the mechanisms underlying MCT8-deficient brain development...
November 26, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29173053/alfred-walter-campbell-s-return-to-australia
#10
Malcolm Macmillan
Alfred Walter Campbell (1868-1937) established the basic cytoarchitectonic structure of the human brain while he was working as a pathologist at the Rainhill Lunatic Asylum near Liverpool in the United Kingdom. He returned to Australia in 1905 and continued doing research while establishing a neurological practice. His research over the next 17 years focused on four topics: (a) localisation in the cerebellum, (b) the neuroses and psychoses in war, (c) localisation in the cerebral cortex of the gorilla, and (d) the causes and pathology of the mysterious Australian "X" Disease (later known as Murray Valley encephalitis)...
November 27, 2017: Journal of the History of the Neurosciences
https://www.readbyqxmd.com/read/29172226/-research-networks-in-public-health-requirements-for-sustainability-and-effectiveness-a-sociological-perspective
#11
Holger Pfaff, Silke Ohlmeier
The Public Health White Paper draws up a vision of public health as a living, decentralized network that can help improve the health of the population in a sustained fashion. However, the central question remains open as to which prerequisites public health networks should fulfill in order to be effective in the long term. The aim of this paper is to provide a sociological view of the issue and offer some discussion ideas. Parsons' structural functionalism leads to the thesis that science networks in public health require structures that ensure that the 4 basic functions of viable social networks - (1) adaptation, (2) goal attainment, (3) integration and (4) latent pattern maintenance - are fulfilled...
November 2017: Das Gesundheitswesen
https://www.readbyqxmd.com/read/29167629/the-effects-of-phacoemulsification-and-intraocular-lens-implantation-on-anatomical-and-functional-parameters-in-patients-with-primary-angle-closure-a-prospective-study-an-american-ophthalmological-society-thesis
#12
Carlo Enrico Traverso, Carlo Alberto Cutolo
Purpose: To investigate the clinical, anatomical, and patient-reported outcomes of phacoemulsification (PE) with intraocular lens implantation performed to treat primary angle closure (PAC) and primary angle-closure glaucoma (PACG). Methods: Patients were evaluated at baseline and at 6 months after PE. The examination included visual acuity, intraocular pressure (IOP), visual field, optic nerve head, endothelial cell count (ECC), aqueous depth, and ocular biometric parameters...
August 2017: Transactions of the American Ophthalmological Society
https://www.readbyqxmd.com/read/29150761/comparative-study-of-fluvial-lakes-in-floodplains-of-the-elbe-lu%C3%A5-nice-and-svratka-rivers-based-on-hydrochemical-and-biological-approach
#13
Petra Havlíková, Tomáš Chuman, Bohumír Janský
The aim of the thesis was to specify key differences in chemistry and biota (zooplankton communities) among fluvial lakes in three regions of the Czech Republic: the central part of the Elbe River, the upper part of the Lužnice River and the upper part of the Svratka River. The ten studied lakes of the three regions differ in size, geology, shading, connection with the river and the level of anthropogenic impact. The following hypotheses were tested: (1) The water chemistry of fluvial lakes significantly differs in different floodplains...
November 17, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29147104/predictors-of-intraocular-pressure-after-phacoemulsification-in-primary-open-angle-glaucoma-eyes-with-wide-versus-narrower-angles-an-american-ophthalmological-society-thesis
#14
Shan C Lin, Marisse Masis, Travis C Porco, Louis R Pasquale
Purpose: To assess if narrower-angle status and anterior segment optical coherence tomography (AS-OCT) parameters can predict intraocular pressure (IOP) drop in primary open-angle glaucoma (POAG) patients after cataract surgery. Methods: This was a prospective case series of consecutive cataract surgery patients with POAG and no peripheral anterior synechiae (PAS) using a standardized postoperative management protocol. Preoperatively, patients underwent gonioscopy and AS-OCT...
August 2017: Transactions of the American Ophthalmological Society
https://www.readbyqxmd.com/read/29146406/central-nervous-involvement-by-chronic-lymphocytic-leukaemia
#15
Dariusz Szczepanek, Ewa Wąsik-Szczepanek, Agnieszka Szymczyk, Małgorzata Wach, Maria Cioch, Monika Podhorecka, Ewelina Grywalska, Marek Hus
Inclusion of the central nervous system (CNS) in the course of chronic lymphocytic leukaemia (CLL) is rare. At the moment no risk factors or proven treatment methods are known. The disease is described both in its early phase and during its acceleration period, thus it has been suggested that there might be independent mechanisms influencing the development of this condition. As there are no unified diagnostic procedure algorithms each patient needs to be assessed individually. CLL can manifest mostly in elderly people, for whom a possibility of development of neurological disorders with their aetiology different from leukaemia, should also be taken into consideration...
November 1, 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/29140916/gender-disparities-in-medical-student-research-awards-a-thirteen-year-study-from-the-yale-school-of-medicine
#16
Joseph T King, Nancy R Angoff, John N Forrest, Amy C Justice
PURPOSE: Instruction in research conduct is currently required, and many U.S. medical schools require students to complete a research project. Each year all Yale School of Medicine (YSM) graduating students submit a research thesis, and ~5% are awarded highest honors. Gender disparities exist in areas related to physician research productivity, including academic rank, research funding, and publications. The authors asked whether gender disparities exist for medical student research. METHOD: The authors conducted a retrospective review of 1,120 theses submitted by graduating medical students from 2003-2015 at YSM and collected data on gender, mentoring, research type, sponsoring department, and other characteristics...
November 14, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29124116/toward-common-mechanisms-for-risk-factors-in-alzheimer-s-syndrome
#17
REVIEW
Miguel Medina, Zaven S Khachaturian, Martin Rossor, Jesús Avila, Angel Cedazo-Minguez
The global strategic goal of reducing health care cost, especially the prospects for massive increases due to expanding markets for health care services demanded by aging populations and/or people with a wide range of chronic disorders-disabilities, is a complex and formidable challenge with many facets. Current projections predict marked increases in the demand for health driven by both the exponential climb in the prevalence of chronic disabilities and the increases in the absolute numbers of people in need of some form of health care...
November 2017: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://www.readbyqxmd.com/read/29121048/anatomical-variations-of-the-deep-head-of-cruveilhier-of-the-flexor-pollicis-brevis-and-its-significance-for-the-evolution-of-the-precision-grip
#18
Samuel S Dunlap, M Ashraf Aziz, Janine M Ziermann
Cruveilhier described in 1834 the human flexor pollicis brevis (FPB), a muscle of the thenar compartment, as having a superficial and a deep head, respectively, inserted onto the radial and ulnar sesamoids of the thumb. Since then, Cruveilhier's deep head has been controversially discussed. Often this deep head is confused with Henle's "interosseous palmaris volaris" or said to be a slip of the oblique adductor pollicis. In the 1960s, Day and Napier described anatomical variations of the insertions of Cruveilhier's deep head, including its absence, and hypothesized, that the shift of the deep head's insertion from ulnar to radial facilitated "true opposability" in anthropoids...
2017: PloS One
https://www.readbyqxmd.com/read/29120112/sociology-as-moral-philosophy-and-vice-versa
#19
Frédéric Vandenberghe
In this article, I want to make an attempt to reconnect sociology to moral philosophy and moral philosophy to sociology. The thesis I want to defend is that sociology continues by other means the venerable tradition of practical and moral philosophy. Like its forebears, it stands and falls with a defense of "practical wisdom" (Aristotle) and "practical reason" (Kant). The development of a moral sociology presupposes, however, that one recognizes and rejects Max Weber's theory of axiological neutrality as an extremist position and that one carefully articulates prescriptive and descriptive, internal and external, as well as observer and actor positions...
November 2017: Canadian Review of Sociology, Revue Canadienne de Sociologie
https://www.readbyqxmd.com/read/29117734/risk-factors-for-a-delay-in-medical-education-results-of-an-online-survey-among-four-german-medical-schools
#20
Jens Walldorf, Martin R Fischer
BACKGROUND: Delayed study progress in medical school is a challenging issue for the tax paying community, the faculty and the medical students themselves. Reasons for a delay might be different from known risk factors for academic difficulties. METHODS: An online survey regarding delays in the study progress and including a personality test (BFI-10) was presented to medical students from four German medical schools after completion of their 3rd year of study. RESULTS: Of 617 students, 51...
November 9, 2017: Medical Teacher
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