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https://www.readbyqxmd.com/read/29336947/characterization-of-goose-spms-molecular-characterization-and-expression-profiling-of-spms-in-the-goose-ovary
#1
Bo Kang, Qilin Xu, Ziyu Chen, Yongsheng Wu, Su Yang, Xicheng Yang, Zhao Zhang, Dongmei Jiang
Spermine synthase (SPMS), which converts spermidine into spermine, is essential for normal cell growth and development processes in humans and other mammals, but the molecular characterization and expression profiling of the SPMS gene remain undetermined in goose tissues and ovarian follicles. In this study, the SPMS cDNA sequence of the Sichuan white goose was cloned and analysed, and SPMS mRNA expression was profiled in various tissues and ovarian follicles. The results showed that the open reading frame of the SPMS cDNA sequence was 1092 bp in length, encoding 363 amino acids with a molecular weight of 41 kDa...
January 11, 2018: Reproductive Biology
https://www.readbyqxmd.com/read/29327953/multicentric-cryptococcosis-in-a-congo-african-grey-parrot-psittacus-erithacus-erithacus
#2
Raina S K Schunk, Nicholas E Sitinas, Katherine E Quesenberry, Jessica L Grodio
An approximately 10-year-old, female Congo African grey parrot ( Psittacus erithacus erithacus) developed progressive, unilateral exophthalmos and buphthalmos. Survey radiographs revealed a large, coelomic, soft tissue mass, which was confirmed on computed tomography scan. Aspirates of both the contents of the buphthalmic globe and coelomic mass were consistent with Cryptococcus species. Initial results were later confirmed with serum antigen latex agglutination and polymerase chain reaction testing, and the organism was then identified as Cryptococcus neoformans with DNA sequencing...
December 2017: Journal of Avian Medicine and Surgery
https://www.readbyqxmd.com/read/29325092/intravenous-administration-of-scaav9-hexb-normalizes-lifespan-and-prevents-pathology-in-sandhoff-disease-mice
#3
Natalia Niemir, Laura Rouvière, Aurore Besse, Marie T Vanier, Jasmin Dmytrus, Thibaut Marais, Stéphanie Astord, Jean-Philippe Puech, Ganna Panasyuk, Jonathan D Cooper, Martine Barkats, Catherine Caillaud
Sandhoff disease (SD) is a rare inherited disorder caused by a deficiency of β-hexosaminidase activity which is fatal because no effective treatment is available. A mouse model of Hexb deficiency reproduces the key pathognomonic features of SD patients with severe ubiquitous lysosomal dysfunction, GM2 accumulation, neuroinflammation and neurodegeneration, culminating in death at 4 months. Here, we show that a single intravenous neonatal administration of a self-complementary adeno-associated virus 9 vector (scAAV9) expressing the Hexb cDNA in SD mice is safe and sufficient to prevent disease development...
January 8, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29316834/delayed-administration-of-bq788-an-etb-antagonist-after-experimental-traumatic-brain-injury-promotes-recovery-of-blood-brain-barrier-function-and-reduction-of-cerebral-edema-in-mice
#4
Shotaro Michinaga, Akimasa Kimura, Shunichi Hatanaka, Shizuho Minami, Arisa Asano, Yuki Ikushima, Shingo Matsui, Yoshiya Toriyama, Manami Fujii, Yutaka Koyama
Traumatic brain injury (TBI) is induced by immediate physical disruption of brain tissue, and causes death and disability. Studies on experimental TBI animal models show that disruption of the blood-brain barrier (BBB) underlies brain edema and neuroinflammation during the delayed phase of TBI. In neurological disorders, endothelin-1 (ET-1) is involved in BBB dysfunction and brain edema. In this study, the effect of ET antagonists on BBB dysfunction and brain edema were examined in a mouse focal TBI model using lateral fluid percussion injury (FPI)...
January 9, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29315764/testican-1-as-a-novel-diagnosis-of-sepsis
#5
Yuri Lee, Wonhwa Lee, Hyun-Ha Chang, Shin-Woo Kim, Jaehong Kim, Jong-Sup Bae
The development of new sepsis-specific biomarkers is mandatory to improve the detection and monitoring of the disease. Testican-1 is a highly conserved, multidomain proteoglycan that is most prominently expressed in the thalamus of the brain, and is upregulated in activated astroglial cells of the cerebrum. The aim of this study was to evaluate blood levels of Testican-1 in septic patients. A prospective study of 82 patients with sepsis was conducted. Furthermore, C57BL/6 mice were administrated with lipopolysaccharide (LPS), high mobility group box 1 (HMGB1) protein or subjected to cecal ligation and puncture (CLP) surgery...
January 8, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29311092/pharmacodynamics-of-flubendazole-for-cryptococcal-meningoencephalitis-repurposing-and-reformulation-of-an-anti-parasitic-agent-for-a-neglected-fungal-disease
#6
Gemma L Nixon, Laura McEntee, Adam Johnson, Nikki Farrington, Sarah Whalley, Joanne Livermore, Cristien Natal, Gina Washbourn, Jaclyn Bibby, Neil Berry, Jodi Lestner, Megan Truong, Andrew Owen, David Lalloo, Ian Charles, William Hope
Current therapeutic options for cryptococcal meningitis are limited by toxicity, global supply and emergence of resistance. There is an urgent need to develop additional antifungal agents that are fungicidal within the central nervous system and preferably orally bioavailable. The benzimidazoles have broad-spectrum anti-parasitic activity, but also have in vitro antifungal activity that includes Cryptococcus neoformans Flubendazole (a benzimidazole) has been reformulated by Janssen Pharmaceutica as an amorphous solid drug nanodispersion to develop an orally bioavailable medicine for the treatment of neglected tropical diseases such as onchocerciasis...
January 8, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29310446/resting-state-fmri-in-primary-sj%C3%A3-gren-syndrome
#7
Wu Xing, Wei Shi, Yueshuang Leng, Xianting Sun, Tingting Guan, Weihua Liao, Xiaoyi Wang
Background The involvement of the central nervous system in primary Sjögren syndrome (pSS) remains controversial. Functional magnetic resonance imaging (fMRI) is a relatively new method that can be applied to investigate the heterogeneity of central nervous system (CNS) involvement in pSS patients through regional homogeneity (ReHo) analysis. Purpose To collect data from pSS patients and healthy controls, and use ReHo analysis to elucidate the neurobiological mechanism of CNS involvement in pSS. Material and Methods Fourteen clinically diagnosed pSS patients and 14 age- and gender-matched healthy controls underwent resting-state fMRI...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29284207/production-of-transgenic-pigs-using-the-pgfap-creert2-egfploxp-inducible-system-for-central-nervous-system-disease-models
#8
Seon-Ung Hwang, Kiyoung Eun, Junchul David Yoon, Hyunggee Kim, Sang-Hwan Hyun
Transgenic (TG) pigs are an important model for biomedical research, including disease modeling, pharmaceutical toxicity testing, and regenerative medicine. Here, we constructed 2 vector systems using the promoter of the pig glial fibrillary acidic protein (pGFAP) gene, which is an astrocyte cell marker. We established donor TG fibroblasts with pGFAP-CreERT2; LCMV-EGFPLoxP. We evaluated the effect of the transgenes on TG-SCNT embryo development. The cleavage rates were not significantly different among control and transgene-donor group...
December 28, 2017: Journal of Veterinary Science
https://www.readbyqxmd.com/read/29282774/adult-moyamoya-disease-associated-with-abundant-phosphorylated-tau-accumulation-in-the-brainstem-report-of-a-case-with-autopsy-findings
#9
Koichi Okamoto, Isao Naito, Toshio Fukuda, Keiji Suzuki, Masamitsu Takatama
We report the case of a 72-year-old Japanese woman with moyamoya disease (MMD). She experienced her first intracerebral hemorrhage (ICH) at the age of 32 years, and had nine ICHs and/or intraventricular hemorrhages during the following 40 years. Cerebral angiograms and vascular pathologies at autopsy confirmed that the patient suffered from MMD. Macroscopically, there were brown-colored changes in the subarachnoid space, mainly at the base of the brain and around the cerebellar hemispheres. Microscopically, hemosiderin deposits were observed mainly in the old hemorrhagic lesions and on the surface of the brainstem and cerebellum...
December 27, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/29277719/miniature-pig-model-of-human-adolescent-brain-white-matter-development
#10
Meghann C Ryan, Paul Sherman, Laura M Rowland, S Andrea Wijtenburg, Ashley Acheson, Els Fieremans, Jelle Veraart, Dmitry Novikov, L Elliot Hong, John Sladky, P Dana Peralta, Peter Kochunov, Stephen A McGuire
BACKGROUND: Neuroscience research in brain development and disorders can benefit from an in vivo animal model that portrays normal white matter (WM) development trajectories and has a sufficiently large cerebrum for imaging with human MRI scanners and protocols. NEW METHOD: Twelve three-month-old Sinclair™ miniature pigs (Sus scrofa domestica) were longitudinally evaluated during adolescent development using advanced diffusion weighted imaging (DWI) focused on cerebral WM...
December 22, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29273521/the-pathology-and-pathophysiology-of-vascular-dementia
#11
REVIEW
Raj N Kalaria
Vascular dementia (VaD) is widely recognised as the second most common type of dementia. Consensus and accurate diagnosis of clinically suspected VaD relies on wide-ranging clinical, neuropsychological and neuroimaging measures in life but more importantly pathological confirmation. Factors defining subtypes of VaD include the nature and extent of vascular pathologies, degree of involvement of extra and intracranial vessels and the anatomical location of tissue changes as well as time after the initial vascular event...
December 19, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29250826/enhanced-neurogenesis-and-possible-synaptic-reorganization-in-the-piriform-cortex-of-adult-rat-following-kainic-acid-induced-status-epilepticus
#12
Masashi Sakurai, Hiroko Suzuki, Nagi Tomita, Yuji Sunden, Akinori Shimada, Hajime Miyata, Takehito Morita
Epileptic seizure has been reported to enhance adult neurogenesis and induce aberrant synaptic reorganization in the human dentate gyrus in the hippocampal formation. However, adult neurogenesis in the extrahippocampal regions has not been well studied. To investigate seizure-enhanced neurogenesis in the extrahippocampal regions, we performed histological and immunohistochemical as well as western blot analyses on the cerebrum of Sprague-Dawley rats (n = 51, male, 7 weeks old, body weight 250-300 g) treated with intraperitoneal injection of kainic acid (KA, 10 mg/kg) to induce status epilepticus (SE) (n = 36) or normal saline solution (n = 15) followed by 5'-bromo-2-deoxyuridine (BrdU) injection to label newborn cells...
December 18, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/29250206/aggressive-lymphoma-2016-revision-of-the-who-classification
#13
REVIEW
Christine Beham-Schmid
Aggressive lymphomas are a heterogeneous group of malignancies reflecting clinical, biological and pathological diversity. Diffuse large B‑cell lymphoma is the most common histological subtype and therefore will constitute the key aspect in this article. This lymphoma affects patients of all age groups with wide range presentations concerning localization, morphology and molecular mechanisms. The median age at presentation is about 60 years with a slight male preponderance. Up to 50% of patients present with advanced disease...
2017: Memo
https://www.readbyqxmd.com/read/29241217/multinodular-and-vacuolating-neuronal-tumor-of-the-cerebrum-a-benign-nonaggressive-cerebral-lesion
#14
Irem Kapucu, Miral D Jhaveri, Mehmet Kocak, Marinos Kontzialis
No abstract text is available yet for this article.
December 14, 2017: European Neurology
https://www.readbyqxmd.com/read/29237996/a-clinical-case-of-neosporosis-in-a-4-week-old-holstein-friesian-calf-which-developed-hindlimb-paresis-postnatally
#15
Karin Uesaka, Kenji Koyama, Noriyuki Horiuchi, Yoshiyasu Kobayashi, Yoshifumi Nishikawa, Hisashi Inokuma
A 4-week-old female Holstein Friesian calf presented with hindlimb paresis. Neurologic examination of spinal reflexes revealed depressed or absent reflexes of the hindlimbs. Menace responses on both sides disappeared on examination of cranial nerves. The calf was finally diagnosed with Neospora caninum infection by pathological findings including nonsuppurative inflammation associated with cysts in the cerebrum and spinal cord. High levels of antibody against recombinant surface antigen 1 of N. caninum (NcSAG1) were detected by ELISA from both serum and cerebrospinal fluid (CSF) samples...
December 14, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29237287/early-sites-of-virus-replication-after-oral-sivmac251-infection-of-infant-macaques-implications-for-pathogenesis
#16
Angela Amedee, Bonnie Phillips, Kara Jensen, Spencer Robichaux, Nedra Lacour, Mark Burke, Michael Piatak, Jeffrey Lifson, Pamela A Kozlowski, Koen K A Van Rompay, Kristina De Paris
Despite optimization of preventative measures for vertical HIV-1 transmission, daily roughly 400 infants become HIV infected, most of them via breastfeeding. Viral entry has been presumed to occur in the gastrointestinal tract; however, the exact entry site(s) have not been defined. Therefore, we quantified viral RNA and DNA in oral, intestinal and systemic tissues of 15 infant macaques within 48-96 hours after oral SIVmac251 exposure. SIV DNA was detected as early as 48 hours, whereas SIV RNA was typically detected at later time points (72-96 hours)...
December 14, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29228782/antioxidant-defence-in-the-brain-of-one-day-old-chickens-exposed-in-ovo-to-acrylamide
#17
M Batoryna, M W Lis, G Formicki
1. Acrylamide (ACR) is a potent neurotoxicant, although information on its toxic influence on the developing neural system is still limited. We examined the effect of in-ovo-injected ACR on the antioxidant system activity in the brain of new hatched chickens. This model eliminated the mother's contribution to embryonic development. It was also recognised as an adequate model for animal embryonic development. 2. ACR was injected on day 4 of embryogenesis- in doses of 1.25 and 2.50 mg per egg (n=40 eggs per group/120 eggs)...
December 12, 2017: British Poultry Science
https://www.readbyqxmd.com/read/29215095/homozygosity-for-a-nonsense-variant-in-aimp2-is-associated-with-a-progressive-neurodevelopmental-disorder-with-microcephaly-seizures-and-spastic-quadriparesis
#18
Anju Shukla, Aneek Das Bhowmik, Malavika Hebbar, Kadavigere V Rajagopal, Katta M Girisha, Neerja Gupta, Ashwin Dalal
We ascertained two unrelated consanguineous families with two affected children each having microcephaly, refractory seizures, intellectual disability, and spastic quadriparesis. Magnetic resonance imaging showed atrophy of cerebrum, cerebellum and spinal cord, prominent cisterna magna, symmetric T2 hypo-intensities in the bilateral basal ganglia and thinning of corpus callosum. Whole-exome sequencing of three affected individuals revealed c.105C>A [p.(Tyr35Ter)] variant in AIMP2. The variant lies in a common homozygous region of 940 kb on chromosome 7 and is likely to have been inherited from a common ancestor...
January 2018: Journal of Human Genetics
https://www.readbyqxmd.com/read/29201438/pathomorphological-peculiarities-of-tuberculous-meningoencephalitis-associated-with-hiv-infection
#19
Volodymyr M Kozko, Andriy V Bondarenko, Anatoliy V Gavrylov, Olga S Shevchenko, Vitalii V Gargin
Background and aims: One of the most severe manifestation displays of tuberculosis (TB) generalization is meningitis/meningoencephalitis. The purpose of this work was to improve the diagnostic efficiency of TB central nervous system (CNS) affection in human immunodeficiency virus (HIV)-infected persons. Materials and methods: Meninges and cerebral tissues, taken from died patients, who were HIV-infected and dead from TB of CNS affection, were investigated histologically...
September 2017: Interventional Medicine & Applied Science
https://www.readbyqxmd.com/read/29187254/acute-disseminated-melioidosis-giving-rise-to-pneumonia-and-renal-abscesses-complicated-with-thrombotic-thrombocytopenic-purpura-in-a-post-partum-woman-a-case-report
#20
Piyumi Sachindra Alwis Wijewickrama, Rohini Weerakoon
BACKGROUND: Melioidosis is an established endemic infection in Sri Lanka, caused by Burkholderia pseudomallei, a gram negative bacterium distributed in saprophytes in soil and surface water. Main mode of transmission is via percutaneous inoculation. Pneumonia is the most common presentation in acute disease. CASE PRESENTATION: We report a 33 year old previously healthy Sinhalese female with an occupational exposure to surface water in paddy fields, who was on postpartum day 6 following an uncomplicated pregnancy and delivery via an elective caesarian section...
November 29, 2017: BMC Research Notes
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