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https://www.readbyqxmd.com/read/29671873/t-cell-derived-ifn-%C3%AE-downregulates-protective-group-2-innate-lymphoid-cells-in-murine-lupus-erythematosus
#1
Mathis Düster, Martina Becker, Ann-Christin Gnirck, Malte Wunderlich, Ulf Panzer, Jan-Eric Turner
Innate lymphoid cells (ILCs) are important regulators of the immune response and play a crucial role in the restoration of tissue homeostasis after injury. GATA-3+ IL-13- and IL-5-producing group 2 innate lymphoid cells (ILC2s) have been shown to promote tissue repair in barrier organs, but despite extensive research on ILCs in the recent years, their potential role in autoimmune diseases is still incompletely understood. In the present study, we investigate the role of ILC2s in the MRL/MpJ-Faslpr (MRL-lpr) mouse model for severe organ manifestation of systemic lupus erythematosus (SLE)...
April 19, 2018: European Journal of Immunology
https://www.readbyqxmd.com/read/29657868/outcomes-of-hydralazine-induced-renal-vasculitis
#2
Homa Timlin, Jason E Liebowitz, Khusleen Jaggi, Duvuru Geetha
Objective: Hydralazine has been implicated as an etiologic agent for lupus-like syndrome and vasculitis. Hydralazine-induced vasculitis frequently affects the kidney, but the long-term renal outcomes in these patients have not yet been studied. Methods: Patients who had a diagnosis of ANCA-associated vasculitis (AAV) and were on hydralazine at the time of AAV diagnosis were included in this retrospective cohort study. Clinical and laboratory data were obtained from the review of medical records...
March 2018: European Journal of Rheumatology
https://www.readbyqxmd.com/read/29657218/rapidly-progressive-glomerulonephritis-a-wild-card-manifestation-of-lupus-nephritis
#3
Opeyemi O Komolafe
A significant proportion of individuals with systemic lupus erythematosus (SLE) will have clinical or laboratory evidence of renal involvement at some point in the course of their disease. Lupus nephritis (LN) is one of the more important systemic manifestations of SLE and although progression to end-stage renal disease (ESRD) is not usually the norm, a significant minority of patients will do so, some in a rather dramatic fashion. It is in such instances that LN constitutes a true nephrologic emergency. Gratifyingly, it is rarely a silent emergency and heightened awareness amongst clinicians about its unpredictable course should lead to earlier recognition and intervention...
March 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29657209/spectrum-of-biopsy-proven-renal-diseases-a-single-center-experience
#4
Lakshminarayana R Gopaliah, Indu Sudakaran, Seethalekshmy Vijayan Nalumakkal, Ranjit Narayanan, Biju Meckattuparamban Vareed
Kidney biopsy is one of the most important tools in the assessment of kidney disease as histopathological diagnosis promotes evidence-based practice in Nephrology. This study included 271 consecutive percutaneous kidney biopsies (145 males and 126 females) performed at EMS Memorial Cooperative Hospital, Perinthalmanna, Kerala, India, from September 2009 to March 2016. Among the biopsy-proven renal diseases (BPRD), primary glomerular diseases (PGD) were the most common (77.78%) followed by secondary glomerular diseases (SGD) (12...
March 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29652635/far2-is-associated-with-kidney-disease-in-mice-and-humans
#5
Grant Backer, Sean Eddy, Susan M Sheehan, Yuka Takemon, Anna Reznichenko, Holly S Savage, Matthias Kretzler, Ron Korstanje
Mesangial matrix expansion is an important process in the initiation of chronic kidney disease, yet the genetic factors driving its development are unknown. Our previous studies have implicated Far2 as a candidate gene associated with differences in mesangial matrix expansion between mouse inbred strains. Consistent with the hypothesis that increased expression of Far2 leads to mesangial matrix expansion through increased production of platelet-activating factor precursors, we show that FAR2 is capable of mediating de novo platelet-activating factor synthesis in vitro and driven by the transcription factor NKX3...
April 13, 2018: Physiological Genomics
https://www.readbyqxmd.com/read/29625558/predominant-but-silent-c1q-deposits-in-mesangium-on-transplanted-kidneys-long-term-observational-study
#6
Takahiro Kanai, Yuko Akioka, Kenichiro Miura, Masataka Hisano, Junki Koike, Yutaka Yamaguchi, Motoshi Hattori
BACKGROUND: C1q nephropathy (C1qN) was first described as glomerular disease characterized by predominant meangial C1q deposits in patients with proteinuria and no evidence of systemic lupus erythematosus. Several studies, however, revealed the clinical heterogeneity of C1qN, showing some cases with normal urinalysis. To confirm the existence of cases with predominant mesangial C1q deposits and negative or mild proteinuria and/or hematuria, we investigated renal graft biopsy specimens showing negative to mild proteinuria (less than or equal to 1+ by dip stick test) and/or hematuria...
April 6, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29624903/lupus-nephritis-low-urinary-dnase-i-levels-reflect-loss-of-renal-dnase-i-and-may-be-utilized-as-a-biomarker-of-disease-progression
#7
Hege L Pedersen, Kjersti D Horvei, Dhivya Thiyagarajan, Gudrun E Norby, Natalya Seredkina, Gabriella Moroni, Gro Ø Eilertsen, Hallvard Holdaas, Erik H Strøm, Gunnstein Bakland, Pier-Luigi Meroni, Ole P Rekvig
Renal DNase I is lost in advanced stages of lupus nephritis. Here, we determined if loss of renal DNase I reflects a concurrent loss of urinary DNase I, and whether absence of urinary DNase I predicts disease progression. Mouse and human DNase I protein and DNase I endonuclease activity levels were determined by western blot, gel, and radial activity assays at different stages of the murine and human forms of the disease. Cellular localization of DNase I was analyzed by immunohistochemistry, immunofluorescence, confocal microscopy, and immunoelectron microscopy...
February 21, 2018: Journal of Pathology. Clinical Research
https://www.readbyqxmd.com/read/29623845/is-treat-to-target-in-lupus-nephritis-realistic-in-clinical-practice
#8
Chi Chiu Mok
The treat-to-target (T2T) principle has been advocated in a number of inflammatory and non-inflammatory medical illnesses. Tight control of disease activity has been shown to improve the outcome of rheumatoid arthritis and psoriatic arthritis as compared to the conventional approach. However, whether T2T can be applied to patients with lupus nephritis is still under hot discussion. Treatment of lupus nephritis should target at inducing and maintaining remission of the kidney inflammation so as to preserve renal function and improve survival in the long-term...
April 5, 2018: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/29619486/assessment-of-the-etiologies-and-renal-outcomes-of-rapidly-progressive-glomerulonephritis-in-pediatric-patients-at-king-abdulaziz-university-hospital-jeddah-saudi-arabia
#9
Faisal G Mosaad, Omar Mohammed Saggaf, Khaled T Aletwady, Khaled Y Mohammed Jan, Khalid Al-Qarni, Rakan S Al-Harbi, Osama Y Safdar
OBJECTIVES: To investigate the etiologies and outcomes of rapidly progressive glomerulonephritis (RPGN) in pediatric patients at King Abdulaziz University Hospital (KAUH) in Jeddah, Saudi Arabia. METHODS: A retrospective study was conducted in 19 pediatric patients who were diagnosed with RPGN between 2006 and 2016 at the Department of Pediatric Medicine at KAUH. Associations between variables were evaluated using independent t-test, one-way analysis of variance (ANOVA) and Chi-squared tests...
April 2018: Saudi Medical Journal
https://www.readbyqxmd.com/read/29611341/outcome-and-predictors-of-renal-survival-in-patients-with-lupus-nephritis-comparison-between-cyclophosphamide-and-mycophenolate-mofetil
#10
Young Bin Joo, Young Mo Kang, Hyoun-Ah Kim, Chang-Hee Suh, Tae-Jong Kim, Yong-Wook Park, Jisoo Lee, Joo-Hyun Lee, Dae Hyun Yoo, Sang-Cheol Bae, Hye-Soon Lee, So-Young Bang
AIM: To compare renal outcomes between cyclophosphamide (CYC) and mycophenolate mofetil (MMF), and attempt to identify a predictor of renal survival. METHODS: A total of 99 patients with class III-V lupus nephritis (LN) and treated with CYC or MMF were enrolled. The remission rate and predictors of poor renal outcomes in LN were assessed. RESULTS: The mean age at LN diagnosis was 31.7 years. The baseline characteristics of the two groups were similar except for the chronicity index (3...
April 2, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29608575/ozanimod-rpc1063-a-selective-s1pr1-and-s1pr5-modulator-reduces-chronic-inflammation-and-alleviates-kidney-pathology-in-murine-systemic-lupus-erythematosus
#11
Kristen R Taylor Meadows, Marcos W Steinberg, Bryan Clemons, Matthew E Stokes, Gregory J Opiteck, Robert Peach, Fiona L Scott
Ozanimod (RPC1063) is a specific and potent small molecule modulator of the sphingosine 1-phosphate receptor 1 (S1PR1) and receptor 5 (S1PR5), which has shown therapeutic benefit in clinical trials of relapsing multiple sclerosis and ulcerative colitis. Ozanimod and its active metabolite, RP-101075, exhibit a similar specificity profile at the S1P receptor family in vitro and pharmacodynamic profile in vivo. The NZBWF1 mouse model was used in therapeutic dosing mode to assess the potential benefit of ozanimod and RP-101075 in an established animal model of systemic lupus erythematosus...
2018: PloS One
https://www.readbyqxmd.com/read/29606501/crispr-gene-editing-in-the-kidney
#12
Nelly M Cruz, Benjamin S Freedman
CRISPR is a nuclease guidance system that enables rapid and efficient gene editing of specific DNA sequences within genomes. We review applications of CRISPR for the study and treatment of kidney disease. CRISPR enables functional experiments in cell lines and model organisms to validate candidate genes arising from genetic studies. CRISPR has furthermore been used to establish the first models of genetic disease in human kidney organoids derived from pluripotent stem cells. These gene-edited organoids are providing new insight into the cellular mechanisms of polycystic kidney disease and nephrotic syndrome...
March 30, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29600248/cd11b-activity-modulates-pathogenesis-of-lupus-nephritis
#13
REVIEW
Samia Q Khan, Imran Khan, Vineet Gupta
Lupus nephritis (LN) is a common complication of systemic lupus erythematosus (SLE) with unclear etiology and limited treatment options. Immune cell infiltration into the kidneys, a hallmark of LN, triggers tissue damage and proteinuria. CD11b, the α-chain of integrin receptor CD11b/CD18 (also known as αMβ2 , Mac-1, and CR3), is highly expressed on the surface of innate immune cells, including macrophages and neutrophils. Genetic variants in the human ITGAM gene, which encodes for CD11b, are strongly associated with susceptibility to SLE, LN, and other complications of SLE...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29597189/the-spectrum-of-glomerulopathies-in-kashmir-a-tertiary-care-experience
#14
Irshad Sirwal, Ibrahim Masoodi
BACKGROUND: There is a paucity of data on the spectrum of renal diseases prevalent in the Jammu and Kashmir region. OBJECTIVES: To determine the spectrum of glomerulopathies in adult patients attending a tertiary care centre. METHODS: Two hundred and twenty-one adequate biopsies from native kidneys of adult patients who presented with features suggestive of glomerular diseases at Sheri Kashmir Institute of medical sciences Srinagar Kashmir for the last 8 years were studied in a retrospective manner...
March 29, 2018: Nephron
https://www.readbyqxmd.com/read/29594138/changes-in-the-spectrum-of-kidney-diseases-an-analysis-of-40-759-biopsy-proven-cases-from-2003-to-2014-in-china
#15
Jin-Hua Hou, Hui-Xian Zhu, Min-Lin Zhou, Wei-Bo Le, Cai-Hong Zeng, Shao-Shan Liang, Feng Xu, Dan-Dan Liang, Si-Jia Shao, Ye Liu, Zhi-Hong Liu
Objectives: To evaluate the changing spectrum of kidney diseases over time in China using renal biopsy-proven cases. Methods: All patients over the age of 14 years who were diagnosed with a kidney disease by renal biopsy in the Renal Biopsy Registry of the National Clinical Research Center of Kidney Diseases in Jinling Hospital, Nanjing, from 2003 to 2014 were included. Results: In total, 40,759 cases of renal biopsy were analyzed. The mean age of the patients was 36...
February 2018: Kidney Diseases
https://www.readbyqxmd.com/read/29593732/a-distinct-t-follicular-helper-cell-subset-infiltrates-the-brain-in-murine-neuropsychiatric-lupus
#16
Shweta Jain, Ariel Stock, Fernando Macian, Chaim Putterman
Neuropsychiatric symptoms in systemic lupus erythematosus (SLE) are not uncommon, yet the mechanisms underlying disease initiation and progression in the brain are incompletely understood. Although the role of T cells in other lupus target organs such as the kidney is well defined, which T cells contribute to the pathogenesis of neuropsychiatric SLE is not known. The present study was aimed at characterizing the CD4 T cell populations that are present in the choroid plexus (CP) of MRL/MpJ-fas lpr mice, the primary site of brain infiltration in this classic lupus mouse model which exhibits a prominent neurobehavioral phenotype...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29579358/a-22-year-old-woman-with-systemic-lupus-erythematosus-presents-with-two-damaged-kidneys-one-seizure-no-platelets-and-many-possible-diagnoses
#17
Lisa Zickuhr, Leal C Herlitz, Soumya Chatterjee
A 22-year-old woman with a history of systemic lupus erythematosus (SLE) was admitted with progressive edema. Two years before hospitalization, a local rheumatologist diagnosed her with SLE based on a syndrome of oral ulcers, inflammatory arthritis, discoid lupus lesions, and Raynaud phenomenon. Serum analysis revealed high-titer anti-nuclear antibodies, the presence of anti-SSA, anti-SSB, anti-Smith, anti-RNP, anti-histone, and anti-double-stranded DNA antibodies, and low complement (C3 and C4) levels. Hydroxychloroquine and topical clobetasol ointment were started...
March 26, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29572747/severe-nasomaxillary-hypoplasia-binder-phenotype-on-prenatal-us-mri-an-important-marker-for-the-prenatal-diagnosis-of-chondrodysplasia-punctata
#18
Anna R Blask, Eva I Rubio, Kimberly A Chapman, Anne K Lawrence, Dorothy I Bulas
BACKGROUND: Chondrodysplasia punctata is a skeletal dysplasia caused by a diverse spectrum of etiologies, with outcomes ranging from antenatal demise to a normal life span. Prenatal detection can be challenging. OBJECTIVE: To review a series of cases of chondrodysplasia punctata associated with nasomaxillary hypoplasia, known as the Binder phenotype, and to highlight prenatal ultrasound and MRI findings, as well as postnatal MRI and radiographic findings. MATERIALS AND METHODS: We retrospectively reviewed ultrasound, MRI and radiographic imaging findings in postnatally confirmed cases of chondrodysplasia punctata from 2001 to 2017...
March 23, 2018: Pediatric Radiology
https://www.readbyqxmd.com/read/29571440/fu-j-wang-z-lee-k-et-al-transcriptomic-analysis-uncovers-novel-synergistic-mechanisms-in-combination-therapy-for-lupus-nephritis-kidney-int-2018-93-416-429
#19
(no author information available yet)
No abstract text is available yet for this article.
April 2018: Kidney International
https://www.readbyqxmd.com/read/29570934/non-erythropoietic-erythropoietin-derived-peptide-protects-mice-from-systemic-lupus-erythematosus
#20
Bo Huang, Juntao Jiang, Bangwei Luo, Wen Zhu, Yuqi Liu, Zhishang Wang, Zhiren Zhang
Systemic lupus erythematosus (SLE) is an autoimmune disease, which results in various organ pathologies. However, current treatment towards SLE is suboptimal. Erythropoietin (EPO) has been shown to promote SLE recovery, but clinical application can be limited by its haematopoiesis-stimulating effects. EPO-derived helix-B peptide (ARA290) is non-erythrogenic but has been reported to retain the anti-inflammatory and tissue-protective functions of EPO. Therefore, here we investigated the effects and potential mechanisms of ARA290 on SLE...
March 23, 2018: Journal of Cellular and Molecular Medicine
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