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https://www.readbyqxmd.com/read/29458096/identification-of-macrophage-related-candidate-genes-in-lupus-nephritis-using-bioinformatics-analysis
#1
Bingyan Shu, Yi Fang, Weichun He, Junwei Yang, Chunsun Dai
Lupus nephritis (LN) is a chronic autoimmune disorder. Here we try to identify the candidate genes in macrophages related to LN. We performed a systematic search in the Gene Expression Omnibus (GEO) database for microarray in human mononuclear cells and mouse macrophages of LN. The results of clustering and venn analysis of different GEO datasets showed that 8 genes were up-regulated and 2 genes down-regulated in samples from both human and mouse LN. The data from gene network and GO analysis revealed that CD38 and CCL2 were localized in the core of the network...
February 16, 2018: Cellular Signalling
https://www.readbyqxmd.com/read/29456665/involvement-of-tweak-and-the-nf-%C3%AE%C2%BAb-signaling-pathway-in-lupus-nephritis
#2
Fang Sun, Jian Teng, Pengfei Yu, Wenshuang Li, Jing Chang, Honglei Xu
Previous findings have identified that tumor necrosis factor-related weak inducer of apoptosis (TWEAK) is associated with lupus nephritis (LN) activity status; however, the mechanism involved remains unclear. The present study aimed to investigate the roles of TWEAK and the nuclear factor (NF)-κB signaling pathway in LN. TWEAK levels in the blood and urine of patients with LN or non-LN systemic lupus erythematosus were measured by ELISA and compared with those in healthy controls. TWEAK expression and NF-κB transcriptional activity in the kidney were detected by western blotting, and Ki-67 and cluster of differentiation (CD) 68 expression were assessed using immunofluorescence...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29456648/immunosuppressive-effects-of-hydroxychloroquine-and-artemisinin-combination-therapy-via-the-nuclear-factor-%C3%AE%C2%BAb-signaling-pathway-in-lupus-nephritis-mice
#3
Ning Liang, Yanchun Zhong, Jie Zhou, Bihao Liu, Ruirui Lu, Yezhi Guan, Qi Wang, Chunlin Liang, Yu He, Yuan Zhou, Jianping Song, Jiuyao Zhou
Lupus nephritis (LN) is one of the most common and severe manifestations of systemic lupus erythematosus, leading to permanent renal damage and chronic kidney disease. Hydroxychloroquine (HCQ) serves a protective role against lupus-associated clinical manifestations and medical complications; however, it results in numerous adverse reactions, limiting its long-term use. The aim of the present study was to investigate the combined effect of HCQ and artemisinin (ART) on LN, and to elucidate the underlying mechanisms...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29451067/combined-detection-of-umcp-1-and-utweak-for-rapid-discrimination-of-severe-lupus-nephritis
#4
X W Dong, Z H Zheng, J Ding, X Luo, Z Q Li, Y Li, M Y Rong, Y L Fu, J H Shi, L C Yu, Z B Wu, P Zhu
Reliable markers for the rapid discrimination of severe renal damage remain a vital concern for lupus nephritis (LN). To determine a better tool for kidney damage detection, the present study compared the evaluation ability of novel urinary cytokines and chemokines (namely urinary monocyte chemoattractant protein 1 (uMCP-1), tumor necrosis factor-like weak inducer of apoptosis (uTWEAK)) with traditional serum or urinary markers (namely urinary alpha 1-microgrobulin (uα1-MG), beta 2-microglobulin (uβ2-MG) and serum complement C3 (C3), complement C4 (C4), creatinine (Cr), blood urea nitrogen (BUN) and cystatin C (Cys C)) in discriminating LN renal damage...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29449503/early-renin-angiotensin-system-blockade-improved-short-term-and-longterm-renal-outcomes-in-systemic-lupus-erythematosus-patients-with-antiphospholipid-associated-nephropathy
#5
Cai Yue, Guanhong Li, Yubing Wen, Xuemei Li, Ruitong Gao
OBJECTIVE: To investigate the renal protective effects of early renin-angiotensin-aldosterone system (RAAS) blockade with renin-angiotensin system inhibitors (RASI) in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN). METHODS: Medical data of 57 SLE patients with biopsy-proven aPLN were analyzed. Early RAAS blockade was defined as administration of RASI within 3 months after kidney biopsy and continued for ≥ 12 months...
February 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29446734/cx3cl1-cx3cr1-axis-as-the-therapeutic-potential-in-renal-diseases-friend-or-foe
#6
Quan Zhuang, Ke Cheng, Yingzi Ming
The fractalkine receptor chemokine (C-X3-C motif) receptor 1 (CX3CR1) and its highly selective ligand CX3CL1 mediate chemotaxis and adhesion of immune cells, which are involved in the pathogenesis and progression of numerous inflammatory disorders and malignancies. The CX3CL1/CX3CR1 axis has recently drawn attention as a potential therapeutic target because it is involved in the ontogeny, homeostatic migration, or colonization of renal phagocytes. We performed a Medline/PubMed search to detect recently published studies that explored the relationship between the CX3CL1/CX3CR1 axis and renal diseases and disorders, including diabetic nephropathy, renal allograft rejection, infectious renal diseases, IgA nephropathy, fibrotic kidney disease, lupus nephritis and glomerulonephritis, acute kidney injury and renal carcinoma...
February 13, 2018: Current Gene Therapy
https://www.readbyqxmd.com/read/29446731/vitamin-d-receptor-a-novel-therapeutic-target-for-kidney-diseases
#7
Shikun Yang, Aimei Li, JianWen Wang, Jun Liu, Yachun Han, Wei Zhang, Yan Chun Li, Hao Zhang
BACKGROUND: Kidney disease is a serious problem that adversely affects human health, but critical knowledge is lacking on how to effectively treat established chronic kidney disease. Mounting evidence from animal and clinical studies has suggested that vitamin D receptor (VDR) activation has beneficial effects on various renal diseases. METHOD: A structured search of published research literature regarding VDR structure and function, VDR in various renal diseases (e...
February 14, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29443761/haemolytic-uremic-syndrome-due-to-infection-with-adenovirus-a-case-report-and-literature-review
#8
Victoria Birlutiu, Rares Mircea Birlutiu
RATIONALE: Haemolytic-uremic syndrome is a rare but serious complication of bacterial and viral infections, which is characterized by the triad of: acute renal failure, microangiopathic haemolytic anemia and thrombocytopenia, sometimes severe, requiring peritoneal dialysis. In Europe, hemolytic-uremic syndrome (HUS) in paediatric pathology is primarily caused by Shiga toxin-producing Escherichia coli (STEC) O157, followed by O26. Beside these etiologies, there are other bacterial and viral infections, and also noninfectious ones that have been associated to lead to HUS as well: in the progression of neoplasia, medication-related, post-transplantation, during pregnancy or associated with the antiphospholipid syndrome, systemic lupus erythematosus or family causes with autosomal dominant or recessive inheritance...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29441165/propylthiouracil-induced-anca-negative-cutaneous-small-vessel-vasculitis
#9
Aliaksandr Trusau, Michael L Brit
Propylthiouracil (PTU) is a commonly used medication for the treatment of hyperthyroidism. PTU is known to cause different adverse reactions including autoimmune syndromes. PTU-induced autoimmune syndromes can be classified into drug-induced lupus or drug-induced vasculitis. Differential diagnoses could be very challenging. PTU-induced vasculitis is more common than PTU-induced lupus, and has a higher risk of morbidity and mortality. Usually it is limited to the skin in a form of cutaneous leukocytoclastic vasculitis, but may also affect organs including kidneys and lungs...
2018: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29434134/a-rare-case-of-lupus-nephritis-presenting-as-thrombotic-microangiopathy-with-diffuse-pseudotubulization-possibly-caused-by-atypical-hemolytic-uremic-syndrome
#10
Masafumi Ono, Naro Ohashi, Akio Namikawa, Naoko Katahashi, Sayaka Ishigaki, Naoko Tsuji, Shinsuke Isobe, Takamasa Iwakura, Yukitoshi Sakao, Takayuki Tsuji, Akihiko Kato, Yoshihide Fujigaki, Akira Shimizu, Hideo Yasuda
A 31-year-old woman was admitted to our hospital for thrombotic microangiopathy (TMA). She was diagnosed with systemic lupus erythematosus (SLE) and class V lupus nephritis. She had no aggravated SLE activity, Shiga toxin positivity, ADAMTS13 abnormality, or other causes of secondary TMA. Plasma exchange partially improved TMA, and eculizumab was introduced for suspected atypical hemolytic uremic syndrome (aHUS), as eculizumab was effective in suppressing the TMA activity. A kidney biopsy revealed diffusely organized crescents (pseudotubulization) with glomerular and arteriolar endothelial injury and subepithelial immune deposits...
February 9, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29423350/primary-psychiatric-disorder-masking-the-diagnosis-of-neuropsychiatric-lupus-in-a-patient-with-altered-mental-status-a-case-report
#11
Osman Perez, Kairavee Dave, Aimee Almanzar, Tajul Prodhan, Livasky Concepion
Neuropsychiatric systemic lupus erythematosus (NPSLE) has a wide variety of neurologic and psychiatric features. NPSLE symptoms and the psychotic features of primary psychiatric disorders often overlap with each other. These psychotic features often mask and delay the diagnosis of NPSLE. We present the case of a 59-year-old female previously diagnosed with bipolar disorder and generalized anxiety disorder presenting with altered mental status (AMS), subsequently diagnosed with neuropsychiatric lupus. Initially, medication overdose was suspected as an empty bottle of trazodone was found beside her...
October 23, 2017: Curēus
https://www.readbyqxmd.com/read/29423203/causes-and-predictors-of-mortality-in-biopsy-proven-lupus-nephritis-the-sarawak-experience
#12
Cheng Lay Teh, Vui Eng Phui, Guo Ruey Ling, Lui-Sian Ngu, Sharifah Aishah Wan, Clare Hui-Hong Tan
Background: Lupus nephritis (LN) is a serious manifestation of systemic lupus erythematosus that can be fatal if left untreated. The causes and prognostic predictors of mortality in LN have been well studied in developed countries but evidence is lacking for developing countries. The objective of this study was to investigate the causes and predictors of mortality in a cohort of Malaysian patients with biopsy-proven LN. Methods: We retrospectively studied all patients with biopsy-proven LN treated in Sarawak General Hospital during the period of 2000-15...
February 2018: Clinical Kidney Journal
https://www.readbyqxmd.com/read/29423047/baff-and-april-expression-as-an-autoimmune-signature-of-membranous-nephropathy
#13
Seung Seok Han, Seung Hee Yang, Hyung Ah Jo, Yun Jung Oh, Minkyoung Park, Joo Young Kim, Hajeong Lee, Jung Pyo Lee, Sang-Ho Lee, Kwon Wook Joo, Chun Soo Lim, Yon Su Kim, Dong Ki Kim
Background: Based on the fact that B-cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL) have a regulatory role in B cell biology, excessive levels of these cytokines can promote autoimmune pathogenesis. However, the expression and implication remain unresolved in cases of membranous nephropathy (MN). Results: The plasma BAFF levels of the primary MN patients were higher than those of healthy controls but lower than those of secondary MN patients, whereas the APRIL levels were similar between the MN patients and healthy controls...
January 9, 2018: Oncotarget
https://www.readbyqxmd.com/read/29421495/the-prevalence-of-hla-alleles-in-a-lupus-nephritis-population
#14
Maria Izabel de Holanda, Evandro Klumb, Alicia Imada, Livia A Lima, Isabela Alcântara, Flavia Gregório, Luis Fernando Christiani, Clarice Oliveira Martins, Branca Engel Timoner, Juliana Motta, Roberto Pozzan, Luis Cristóvão Pôrto
BACKGROUND: Systemic lupus erythematosus (SLE) is a severe autoimmune disease that involves multiple organ systems. Lupus nephritis (LN) is a complication of SLE and is associated with poor survival and high morbidity. Many genomic studies have been performed worldwide, and several histocompatibility leukocyte antigen (HLA) loci are linked to lupus susceptibility. OBJECTIVE: The present study evaluated the association of HLA alleles in a lupus patient population, LN group and control group...
February 5, 2018: Transplant Immunology
https://www.readbyqxmd.com/read/29409726/intranuclear-delivery-of-the-transcription-modulation-domain-of-tbet-improved-lupus-nephritis-in-nzb-nzw-f1-lupus-prone-mice
#15
Jae-Seung Moon, Chin Hee Mun, Jung-Ho Kim, Jen-Young Cho, Sung-Dong Park, Tae-Yoon Park, Jin-Su Shin, Chun-Chang Ho, Yong-Beom Park, Sankar Ghosh, Alfred L M Bothwell, Sang-Won Lee, Sang-Kyou Lee
Excessive expression of Tbet and IFNγ is evidence of systemic lupus erythematosus (SLE) in lupus patients. In this study, the nucleus-transducible form of Transcription Modulation Domain (TMD) of Tbet (ntTbet-TMD), which is a fusion protein between Protein Transduction Domain Hph-1 (Hph-1-PTD) and the TMD of Tbet comprising DNA binding domain and isotype-specific domain, was generated to inhibit Tbet-mediated transcription in the interactomic manner. ntTbet-TMD was effectively delivered into the nucleus of the cells and specifically inhibited Tbet-mediated transcription without influencing the differentiation of other T cell subsets and signaling events for T cell activation...
February 3, 2018: Kidney International
https://www.readbyqxmd.com/read/29396242/lupus-nephritis-with-preserved-kidney-function-associated-with-poorer-cardiovascular-risk-control-a-call-for-more-awareness
#16
J A Todolí-Parra, Y Tung-Chen, L Micó, J Gutiérrez, J Hernández-Jaras, J L Ruiz-Cerda
BACKGROUND: Despite the improvement in the prognosis of lupus nephritis (LN), the cardiovascular morbimortality remains high. The early recognition and remission of flares, while trying to avoid the metabolic adverse effects of medication, must be mandatory. AIM: The aim of our study was to assess the cardiovascular (CV) risk profile in a cohort of lupus patients with preserved kidney function after a nephritis episode, compared to patients without a nephritis flare...
January 27, 2018: Hipertensión y Riesgo Vascular
https://www.readbyqxmd.com/read/29395256/membrane-attack-complex-mac-deposition-in-lupus-nephritis-is-associated-with-hypertension-and-poor-clinical-response-to-treatment
#17
Shudan Wang, Ming Wu, Luis Chiriboga, Briana Zeck, H Michael Belmont
OBJECTIVE: To study membrane attack complex in lupus nephritis as a potential biomarker for disease intensity and prognostic indicator for response to treatment. METHODS: Immunohistochemistry was performed using unconjugated, murine anti-human complement C9 on kidney biopsies from 30 SLE patients who fulfilled 4 ACR or SLICC criteria. Clinical parameters were assessed at time of biopsy, 6 and 12 months. RESULTS: 30 renal biopsies were obtained from patients with Class II (2), III (5), IV (8), V (5), III+V (8) and IV+V (2)...
January 6, 2018: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29391916/systemic-lupus-erythematosus-associated-pitfalls-on-18f-fdg-pet-ct-reactive-follicular-hyperplasia-kikuchi-fujimoto-disease-inflammation-and-lymphoid-hyperplasia-of-the-spleen-mimicking-lymphoma
#18
William Makis, Anthony Ciarallo, Milene Gonzalez-Verdecia, Stephan Probst
Systemic lupus erythematosus (SLE) is associated with a variety of inflammatory processes that can affect the lymph nodes, brain, kidneys, and spleen. We present two patients with SLE in whom SLE-associated conditions complicated interpretation of 18F-fluoro-2-deoxy-d-glucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) imaging of the lymph nodes and the spleen. The imaging findings mimicked lymphoma, but histopathological evaluation showed benign processes including reactive follicular hyperplasia in the lymph nodes, Kikuchi-Fujimoto disease in perisplenic lymph nodes, and inflammatory changes and lymphoid hyperplasia in the spleen...
February 2018: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29378858/plasma-cell-depletion-attenuates-hypertension-in-an-experimental-model-of-autoimmune-disease
#19
Erin B Taylor, Michelle T Barati, David W Powell, Hannah R Turbeville, Michael J Ryan
Numerous studies show a direct relation between circulating autoantibodies, characteristic of systemic autoimmune disorders, and primary hypertension in humans. Whether these autoantibodies mechanistically contribute to the development of hypertension remains unclear. Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder characterized by aberrant immunoglobulin production, notably pathogenic autoantibodies, and is associated with prevalent hypertension, renal injury, and cardiovascular disease...
January 29, 2018: Hypertension
https://www.readbyqxmd.com/read/29369972/mtor-inhibition-and-kidney-diseases
#20
Maggie K M Ma, Susan Yung, Tak Mao Chan
Mammalian or mechanistic target of rapamycin (mTOR) is a serine-threonine kinase that plays essential roles in cell growth, proliferation, metabolism, and survival. Increased activation of the mTOR pathway is observed in patients and animal models of renal transplant rejection, autosomal dominant polycystic kidney disease, renal cell carcinoma, diabetic nephropathy, lupus nephritis, and angiomyolipoma. Agents that inhibit mTOR, such as sirolimus and everolimus, are incorporated in immunosuppressive regimens to prevent renal allograft rejection and are often used to facilitate calcineurin inhibitor minimization or to reduce the incidence of tumor recurrence...
February 2018: Transplantation
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