keyword
https://read.qxmd.com/read/38545782/lipoprotein-particles-in-cerebrospinal-fluid
#1
REVIEW
Maki Tsujita, John T Melchior, Shinji Yokoyama
The brain is the most lipid-rich organ in the body, and the intricate interplay between lipid metabolism and pathologies associated with neurodegenerative disorders is being increasingly recognized. The brain is bathed in cerebrospinal fluid (CSF), which, like plasma, contains lipid-protein complexes called lipoproteins that are responsible for extracellular lipid transport. Multiple CSF lipoprotein populations exist, some of which are produced de novo in the central nervous system and others that appear to be generated from protein constituents that are produced in the periphery...
March 28, 2024: Arteriosclerosis, Thrombosis, and Vascular Biology
https://read.qxmd.com/read/38545617/pmma-bone-cement-with-l-arginine-nano-fish-bone-nanocomplex-for-apatite-formation
#2
JOURNAL ARTICLE
Gessica Aurel Khoman, Muhammad Harza Arbaha Kalijaga, Nuning Aisah, Riastuti Fidyaningsih, Jarot Raharjo, Oka P Arjasa, Ekavianty Prajatelistia
Bone cement is one of the materials used in orthopaedics that serves various functions, such as binding bone implants, replacing damaged bones and filling spaces within bones. Various materials have been used to synthesize bone cement, and one promising material for further research is fish bone waste-based bone cement. This study investigates the potential of fish bone waste-based bone cement by incorporating nano fish bone (NFB) and L-arginine (L-Arg) protein into polymethyl methacrylate (PMMA) to examine apatite growth...
March 2024: Royal Society Open Science
https://read.qxmd.com/read/38544618/screening-and-phasewise-management-of-burn-injuries
#3
REVIEW
Neha N Sarda, Snehlata Hingway
Thermal, electrical, chemical, or electromagnetic radiation can cause painful wounds or burns. Spilling hot liquids onto the skin can also cause these kinds of injuries. The two biggest factors contributing to burn injuries in the elderly are smoking and exposure to open flames, while scalding is the primary cause of burn damage in children. Newborns and the elderly make up the majority of burn casualties. In India, there are estimated to be 6-7 million burn cases per year. The high incidence is attributed to the population's illiteracy, poverty, and lack of awareness of safety...
February 2024: Curēus
https://read.qxmd.com/read/38544367/dynamic-pore-network-modeling-of-imbibition-in-real-porous-media-with-corner-film-flow
#4
JOURNAL ARTICLE
Jianlin Zhao, Guangqing Zhang, Keliu Wu, Feifei Qin, Linlin Fei, Dominique Derome, Jan Carmeliet
Wetting films can develop in the corners of pore structures during imbibition in a strongly wetting porous medium, which may significantly influence the two-phase flow dynamics. Due to the large difference in scales between main meniscus and corner film, accurate and efficient modeling of the dynamics of corner film remains elusive. In this work, we develop a novel two-pressure dynamic pore network model incorporating the interacting capillary bundle model to analyze the competition between the main meniscus and corner film flow in real porous media...
March 27, 2024: Langmuir: the ACS Journal of Surfaces and Colloids
https://read.qxmd.com/read/38544285/repeated-exposure-to-eucalyptus-wood-smoke-alters-pulmonary-gene-and-metabolic-profiles-in-male-long-evans-rats
#5
JOURNAL ARTICLE
Samuel J Cochran, Katelyn Dunigan-Russell, Grace M Hutton, Helen Nguyen, Mette C Schladweiler, Dean P Jones, Wanda C Williams, Anna A Fisher, M Ian Gilmour, Janice A Dye, M Ryan Smith, Colette N Miller, Kymberly M Gowdy
Exposure to wildfire smoke is associated with both acute and chronic cardiopulmonary illnesses, which are of special concern for wildland firefighters who experience repeated exposure to wood smoke. It is necessary to better understand the underlying pathophysiology by which wood smoke exposure increases pulmonary disease burdens in this population. We hypothesize that wood smoke exposure produces pulmonary dysfunction, lung inflammation, and gene expression profiles associated with future pulmonary complications...
March 27, 2024: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/38543353/sol-gel-derived-gelatin-bioactive-glass-nanocomposite-biomaterials-incorporating-calcium-chloride-and-calcium-ethoxide
#6
JOURNAL ARTICLE
Rebeca Arambula-Maldonado, Kibret Mequanint
Calcium-containing organic-inorganic nanocomposites play an essential role in developing bioactive bone biomaterials. Ideally, bone substitute materials should mimic the organic-inorganic composition of bone. In this study, the roles of calcium chloride (CaCl2 ) and calcium ethoxide (Ca(OEt)2 ) were evaluated for the development of sol-gel-derived organic-inorganic biomaterials composed of gelatin, bioactive glass (BG) and multiwall carbon nanotubes (MWCNTs) to create nanocomposites that mimic the elemental composition of bone...
March 8, 2024: Polymers
https://read.qxmd.com/read/38543308/synthesis-and-characterization-of-zif-90-nanoparticles-as-potential-brain-cancer-therapy
#7
JOURNAL ARTICLE
Lorenzo Monarca, Francesco Ragonese, Paola Sabbatini, Concetta Caglioti, Matteo Stamegna, Federico Palazzetti, Paolo Sportoletti, Ferdinando Costantino, Bernard Fioretti
Human glioblastoma is probably the most malignant and aggressive among cerebral tumors, of which it represents approximately 80% of the reported cases, with an overall survival rate that is quite low. Current therapies include surgery, chemotherapy, and radiotherapy, with associated consistent side effects and low efficacy. The hardness in reaching the site of action, and overcoming the blood-brain barrier, is a major limitation of pharmacological treatments. In this paper, we report the synthesis and characterization of ZIF-90 (ZIF, Zeolitic Imidazolate Framework) nanoparticles as putative carriers of anticancer drugs to the brain...
March 18, 2024: Pharmaceutics
https://read.qxmd.com/read/38542929/oral-delivery-of-astaxanthin-via-carboxymethyl-chitosan-modified-nanoparticles-for-ulcerative-colitis-treatment
#8
JOURNAL ARTICLE
Wen Zhang, Xinping Zhang, Xinyi Lv, Ao Qu, Wenjing Liang, Limin Wang, Pei Zhao, Zijian Wu
The oral delivery strategy of natural anti-oxidant and anti-inflammatory agents has attracted great attention to improve the effectiveness of ulcerative colitis (UC) treatment. Herein, we developed a novel orally deliverable nanoparticle, carboxymethyl chitosan (CMC)-modified astaxanthin (AXT)-loaded nanoparticles (CMC-AXT-NPs), for UC treatment. The CMC-AXT-NPs were evaluated by appearance, morphology, particle size, ζ-potential, and encapsulation efficiency (EE). The results showed that CMC-AXT-NPs were nearly spherical in shape with a particle size of 34...
March 14, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38542815/analysis-of-fluid-balance-and-urine-values-in-elite-soccer-players-impact-of-different-environments-playing-positions-sexes-and-competitive-levels
#9
JOURNAL ARTICLE
Jaime Sebastiá-Rico, Jose M Soriano, Jesús Sanchis-Chordà, Ángel F García-Fernández, Pedro López-Mateu, Sandra de la Cruz Marcos, José Miguel Martínez-Sanz
Exercise can disrupt the fluid balance, hindering performance and athlete health. Limited data exist on fluid balance responses in varying climates, sexes, and ages. This study aimed to measure and compare fluid balance and urine values among elite soccer players during training at high and low temperatures, examining the differences between sexes, playing positions, and competitive levels within men's soccer. During the 2022-2023 competitive season, a descriptive observational study was conducted on 87 soccer players from an elite Spanish soccer team...
March 21, 2024: Nutrients
https://read.qxmd.com/read/38542494/assessment-of-blood-and-semen-detection-and-dna-collection-from-swabs-up-to-three-months-after-deposition-on-five-different-cloth-materials
#10
JOURNAL ARTICLE
Francisco Medina-Paz, Brandon Kuba, Emily Kryvorutsky, Gabriela Roca, Sara C Zapico
Body fluid identification plays a crucial role in criminal investigations. Because of their presence in many cases, blood and semen are the most relevant body fluids in forensic sciences. Based on antigen-antibody reactions binding unique proteins for each body fluid, serological assays represent one of the most rapid and highly specific tests for blood and semen. Currently, few studies have assessed the factors affecting body fluid identification by applying these assays. This work aimed to study the effect of different fabrics from clothes and time since deposition on identification through immunochromatographic tests for blood and semen, DNA isolation, and STR profiling from these samples...
March 20, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38541000/use-of-bioelectrical-impedance-analysis-to-explore-the-effectiveness-of-stellate-ganglion-block-in-patients-with-post-stroke-complex-regional-pain-syndrome-a-retrospective-pilot-study
#11
JOURNAL ARTICLE
Jin-Whan Ryu, In-Su Hwang, Seung-Kyu Lim
Post-stroke complex regional pain syndrome (CRPS) poses challenges in pain assessment for survivors. Stellate ganglion block (SGB) is a treatment, but evaluating its effectiveness is difficult for patients with communication limitations. Edema, a prominent symptom, can serve as an evaluation marker. Bioelectrical impedance analysis (BIA), assessing body composition and fluid status, is used independently of patient cooperation. This retrospective, observational pilot study aims to explore BIA's utility as an assessment tool post-SGB, revealing the effects and time courses of a single SGB on the bodily composition of post-stroke CRPS patients...
February 28, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38540796/revolutionizing-ischemic-stroke-diagnosis-and-treatment-the-promising-role-of-neurovascular-unit-derived-extracellular-vesicles
#12
REVIEW
Xiangyu Gao, Dan Liu, Kangyi Yue, Zhuoyuan Zhang, Xiaofan Jiang, Peng Luo
Ischemic stroke is a fatal and disabling disease worldwide and imposes a significant burden on society. At present, biological markers that can be conveniently measured in body fluids are lacking for the diagnosis of ischemic stroke, and there are no effective treatment methods to improve neurological function after ischemic stroke. Therefore, new ways of diagnosing and treating ischemic stroke are urgently needed. The neurovascular unit, composed of neurons, astrocytes, microglia, and other components, plays a crucial role in the onset and progression of ischemic stroke...
March 20, 2024: Biomolecules
https://read.qxmd.com/read/38540242/co-culture-models-key-players-in-in-vitro-neurotoxicity-neurodegeneration-and-bbb-modeling-studies
#13
REVIEW
Ana Rita Monteiro, Daniel José Barbosa, Fernando Remião, Renata Silva
The biological barriers existing in the human body separate the blood circulation from the interstitial fluid in tissues. The blood-brain barrier (BBB) isolates the central nervous system from the bloodstream, presenting a dual role: the protection of the human brain against potentially toxic/harmful substances coming from the blood, while providing nutrients to the brain and removing metabolites. In terms of architectural features, the presence of junctional proteins (that restrict the paracellular transport) and the existence of efflux transporters at the BBB are the two major in vivo characteristics that increase the difficulty in creating an ideal in vitro model for drug permeability studies and neurotoxicity assessments...
March 12, 2024: Biomedicines
https://read.qxmd.com/read/38539808/a-novel-plant-based-nutraceutical-combined-with-exercise-can-revert-oxidative-status-in-plasma-and-liver-in-a-diet-induced-obesity-animal-model
#14
JOURNAL ARTICLE
Ana Guzmán-Carrasco, Garyfallia Kapravelou, María López-Jurado, Francisco Bermúdez, Eduardo Andrés-León, Laura C Terrón-Camero, José Prados, Consolación Melguizo, Jesus M Porres, Rosario Martínez
The prevalence of obesity increases alarmingly every year mostly due to external factors such as high-fat and high-refined sugar intake associated with a sedentary lifestyle. It triggers metabolic disorders such as insulin resistance, hyperlipemia, non-alcoholic fatty liver disease, chronic inflammation, oxidative stress, and gut microbiota dysbiosis. The aim of this study was to evaluate the beneficial effects of a combined intervention with caloric restriction, nutraceutical intake, and a mixed training protocol on oxidative stress, inflammation, and gut dysbiosis derived from the development of obesity in a C57BL6/J mouse experimental model of diet-induced obesity (4...
February 23, 2024: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/38539238/neuropathological-changes-associated-with-aberrant-cerebrospinal-fluid-p-tau181-and-a%C3%AE-42-in-alzheimer-s-disease-and-other-neurodegenerative-diseases
#15
JOURNAL ARTICLE
Masanori Kurihara, Tomoyasu Matsubara, Satoru Morimoto, Akira Arakawa, Kensuke Ohse, Kazutomi Kanemaru, Atsushi Iwata, Shigeo Murayama, Yuko Saito
Recent studies suggest that increased cerebrospinal fluid (CSF) phospho-tau is associated with brain amyloid pathology rather than the tau pathology. However, confirmation using gold standard neuropathological assessments remains limited. This study aimed to determine background pathologies associated with aberrant CSF p-tau181 and amyloid-beta 1-42 (Aβ42) in Alzheimer's disease (AD) and other neurodegenerative diseases. We retrospectively studied all patients with antemortem CSF and postmortem neuropathologic data at our institution...
March 27, 2024: Acta Neuropathologica Communications
https://read.qxmd.com/read/38539087/accelerated-lymph-flow-from-infusion-of-crystalloid-fluid-during-general-anesthesia
#16
JOURNAL ARTICLE
Robert G Hahn
BACKGROUND: Kinetic analysis of crystalloid fluid yields a central distribution volume (Vc ) of the same size as the expected plasma volume (approximately 3 L) except during general anesthesia during which Vc might be only half as large. The present study examined whether this difference is due to influence of the intravascular albumin balance. METHODS: A population volume kinetic analysis according to a three-compartment model was performed based on retrospective data from 160 infusion experiments during which 1-2...
March 27, 2024: BMC Anesthesiology
https://read.qxmd.com/read/38539061/clinicopathological-correlation-of-cerebrospinal-fluid-alpha-synuclein-seed-amplification-assay-in-a-behavioral-neurology-autopsy-cohort
#17
JOURNAL ARTICLE
Niyatee Samudra, D Luke Fischer, Steven Lenio, Argentina Lario Lago, Peter A Ljubenkov, Julio C Rojas, William W Seeley, Salvatore Spina, Adam M Staffaroni, Jonathan Tablante, Fattin Wekselman, Jennifer Lamoureux, Luis Concha-Marambio, Lea T Grinberg, Adam L Boxer, Lawren VandeVrede
INTRODUCTION: Lewy body disease (LBD) is a common primary or co-pathology in neurodegenerative syndromes. An alpha-synuclein seed amplification assay (αSyn-SAA) is clinically available, but clinical performance, especially lower sensitivity in amygdala-predominant cases, is not well understood. METHODS: Antemortem CSF from neuropathology-confirmed LBD cases was tested with αSyn-SAA (N = 56). Diagnostic performance and clinicopathological correlations were examined...
March 27, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://read.qxmd.com/read/38538689/development-of-a-formula-for-estimated-glomerular-filtration-rate-in-pregnant-women-from-physiological-hyperfiltration-of-serum-creatinine
#18
JOURNAL ARTICLE
Kwangjin Ahn, Taesic Lee, Jieun Kang, Seong Jin Choi, Sangwon Hwang, Dong Min Seo, Jooyoung Cho, Young Uh
Increased body fluids during pregnancy complicates the application of estimated glomerular filtration rate (eGFR) formulas that are based on body surface area. Furthermore, gestational renal dysfunction cannot be identified if the serum creatinine (SCr) concentration is within the non-pregnant reference interval (RI) despite inadequate pregnancy-related renal hyperfiltration. 1484 SCr measurements from 957 healthy pregnant women were collected. The average SCr value of gestational week (GW) 0-3 was the representative SCr value of non-pregnant status...
March 27, 2024: Scientific Reports
https://read.qxmd.com/read/38538354/-effects-of-helium-oxygen-mechanical-ventilation-on-inflammatory-response-of-diseased-lung-segments-and-diaphragm-function-in-patients-with-pneumonia
#19
JOURNAL ARTICLE
Decai Ren, Lili Zhou, Chengqing Zheng, Shanmin Xie, Ranjie Yu
OBJECTIVE: To investigate the clinical effect of helium-oxygen mechanical ventilation on inflammation of the diseased lung segment and diaphragm function in patients with acute respiratory distress syndrome (ARDS) caused by pneumonia who suffered difficulty weaning from mechanical ventilation. METHODS: A prospective controlled study was conducted. A total of 40 patients with ARDS caused by pneumonia and requiring tracheal intubation with difficulty weaning from mechanical ventilation, admitted to the department of critical care medicine in Pingtan Branch of Fujian Medical University Union Hospital from October 2020 to December 2021 were enrolled...
March 2024: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://read.qxmd.com/read/38538351/-establishing-a-prognostic-prediction-model-for-patients-with-septic-shock-based-on-the-completion-time-of-fluid-resuscitation-and-the-negative-fluid-balance-volumes
#20
JOURNAL ARTICLE
Jiyin Qian, Jing Zhang
OBJECTIVE: To explore the relationship between the completion time of fluid resuscitation as well as negative fluid balance volumes and the prognosis of patients with septic shock, and to try to construct a prediction model based on the completion time of fluid resuscitation and negative fluid balance volumes, and to verify the predictive efficacy of the model on the prognosis of patients with septic shock. METHODS: Patients with septic shock admitted to Wuxi People's Hospital from April 2020 to April 2023 were selected...
March 2024: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
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