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https://www.readbyqxmd.com/read/29351562/clinical-and-ultrasonographic-features-associated-to-response-to-intraarticular-corticosteroid-injection-a-one-year-follow-up-prospective-cohort-study-in-knee-osteoarthritis-patient-with-joint-effusion
#1
Joan Calvet, Cristóbal Orellana, Carlos Galisteo, María García-Manrique, Noemí Navarro, Assumpta Caixàs, Marta Larrosa, Jordi Gratacós
OBJECTIVES: Intraarticular injection is used for pain relief in knee osteoarthritis (OA), but there is not a well defined profile of patient who could get more benefit from it. The purpose of this study was to evaluate the frequency of pain relief at one year after corticosteroids intraarticular injection and to identify clinical factors associated to response in patients with knee osteoarthritis with joint effusion. METHODS: One-year prospective cohort study of patients with knee OA with joint effusion confirmed by ultrasound...
2018: PloS One
https://www.readbyqxmd.com/read/29351470/increased-pro-renin-receptor-expression-in-subfornical-organ-neurons-in-hypertensive-humans
#2
Silvana G Cooper, Darshan P Trivedi, Rieko Yamamoto, Caleb J Worker, Cheng-Yuan Feng, Jacob T Sorensen, Wei Yang, Zhenggang Xiong, Yumei Feng
The central nervous system plays an important role in essential hypertension in humans and in animal models of hypertension through modulation of sympathetic activity, and sodium and body fluid homeostasis. Data from animal models of hypertension suggest that the renin-angiotensin system in the subfornical organ (SFO) of the brain is critical for hypertension development. We recently reported that the brain (pro)renin receptor (PRR) is a novel component of the brain renin-angiotensin system and could be a key initiator of the pathogenesis of hypertension...
December 22, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29350679/proangiogenic-functions-of-an-rgd-slay-containing-osteopontin-icosamer-peptide-in-huvecs-and-in-the-postischemic-brain
#3
Hahnbie Lee, Yin-Chuan Jin, Seung-Woo Kim, Il-Doo Kim, Hye-Kyung Lee, Ja-Kyeong Lee
Osteopontin (OPN) is a phosphorylated glycoprotein secreted into body fluids by various cell types. OPN contains arginine-glycine-aspartate (RGD) and serine-leucine-alanine-tyrosine (SLAY) motifs that bind to several integrins and mediate a wide range of cellular processes. In the present study, the proangiogenic effects of a 20-amino-acid OPN peptide (OPNpt20) containing RGD and SLAY motifs were examined in human umbilical vein endothelial cells (HUVECs) and in a rat focal cerebral ischemia model. OPNpt20 exerted robust proangiogenic effects in HUVECs by promoting proliferation, migration and tube formation...
January 19, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29350399/biological-functions-of-elabela-a-novel-endogenous-ligand-of-apj-receptor
#4
REVIEW
Jin Xu, Linxi Chen, Zhisheng Jiang, Lanfang Li
The G protein-coupled receptor APJ and its cognate ligand, apelin, are widely expressed throughout human body. They are implicated in different key physiological processes such as angiogenesis, cardiovascular functions, fluid homeostasis and energy metabolism regulation. Recently, a new endogenous peptidic ligand of APJ, named Elabela, has been identified and shown to play a crucial role in embryonic development. In addition, increasing evidences show that Elabela is also intimate associated with a large number of physiological processes in adulthood...
January 19, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29349297/organic-matter-in-extraterrestrial-water-bearing-salt-crystals
#5
Queenie H S Chan, Michael E Zolensky, Yoko Kebukawa, Marc Fries, Motoo Ito, Andrew Steele, Zia Rahman, Aiko Nakato, A L David Kilcoyne, Hiroki Suga, Yoshio Takahashi, Yasuo Takeichi, Kazuhiko Mase
Direct evidence of complex prebiotic chemistry from a water-rich world in the outer solar system is provided by the 4.5-billion-year-old halite crystals hosted in the Zag and Monahans (1998) meteorites. This study offers the first comprehensive organic analysis of the soluble and insoluble organic compounds found in the millimeter-sized halite crystals containing brine inclusions and sheds light on the nature and activity of aqueous fluids on a primitive parent body. Associated with these trapped brines are organic compounds exhibiting wide chemical variations representing organic precursors, intermediates, and reaction products that make up life's precursor molecules such as amino acids...
January 2018: Science Advances
https://www.readbyqxmd.com/read/29347876/risk-of-overhydration-and-low-lean-tissue-index-as-measured-using-a-body-composition-monitor-in-patients-on-hemodialysis-a-systemic-review-and-meta-analysis
#6
Seun Deuk Hwang, Jin Ho Lee, Seoung Woo Lee, Joong Kyung Kim, Moon-Jae Kim, Joon Ho Song
Overhydration and sarcopenia, related to an individual's nutritional status, have been associated with increased cardiovascular mortality and poor prognosis in patients on hemodialysis. The purpose of this study was to investigate the prediction of overhydration and sarcopenia on mortality in patients on hemodialysis using a body composition monitor. We conducted a systematic review and meta-analysis using a random-effects model. We searched the Cochrane Central Register, OVID MEDLINE, EMBASE and PubMed databases for all studies published prior to December 9, 2016 and reviewed the reference lists of relevant reviews, registered trials and relevant conference proceedings...
November 2018: Renal Failure
https://www.readbyqxmd.com/read/29347505/diffusivity-of-e-coli-like-microswimmers-in-confined-geometries-the-role-of-the-tumbling-rate
#7
Giorgia Guccione, Daniela Pimponi, Paolo Gualtieri, Mauro Chinappi
We analyzed the effect of confinement on the effective diffusion of a run-and-tumble E. coli-like flagellated microswimmer. We used a simulation protocol where the run phases are obtained via a fully resolved swimming problem, i.e., Stokes equations for the fluid coupled with rigid-body dynamics for the microorganism, while tumbles and collisions with the walls are modeled as random reorientation of the microswimmer. For weak confinement, the swimmer is trapped in circular orbits close to the solid walls. In this case, optimal diffusivity is observed when the tumbling frequency is comparable with the angular velocity of the stable orbits...
October 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347313/exact-mean-energy-expansion-of-ginibre-s-gas-for-coupling-constants-%C3%AE-2%C3%A3-oddinteger
#8
R Salazar, G Téllez
Using the approach of a Vandermonde determinant to the power Γ=Q^{2}/k_{B}T expansion on monomial functions, a way to find the excess energy U_{exc} of the two-dimensional one-component plasma (2DOCP) on hard and soft disks (or a Dyson gas) for odd values of Γ/2 is provided. At Γ=2, the present study not only corroborates the result for the particle-particle energy contribution of the Dyson gas found by Shakirov [Shakirov, Phys. Lett. A 375, 984 (2011)10.1016/j.physleta.2011.01.004] by using an alternative approach, but also provides the exact N-finite expansion of the excess energy of the 2DOCP on the hard disk...
December 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347303/predicting-tensorial-electrophoretic-effects-in-asymmetric-colloids
#9
Aaron J Mowitz, T A Witten
We formulate a numerical method for predicting the tensorial linear response of a rigid, asymmetrically charged body to an applied electric field. This prediction requires calculating the response of the fluid to the Stokes drag forces on the moving body and on the countercharges near its surface. To determine the fluid's motion, we represent both the body and the countercharges using many point sources of drag known as Stokeslets. Finding the correct flow field amounts to finding the set of drag forces on the Stokeslets that is consistent with the relative velocities experienced by each Stokeslet...
December 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347182/propulsion-via-flexible-flapping-in-granular-media
#10
Zhiwei Peng, Yang Ding, Kyle Pietrzyk, Gwynn J Elfring, On Shun Pak
Biological locomotion in nature is often achieved by the interaction between a flexible body and its surrounding medium. The interaction of a flexible body with granular media is less understood compared with viscous fluids partially due to its complex rheological properties. In this work, we explore the effect of flexibility on granular propulsion by considering a simple mechanical model in which a rigid rod is connected to a torsional spring that is under a displacement actuation using a granular resistive force theory...
July 2017: Physical Review. E
https://www.readbyqxmd.com/read/29346937/uhlenbeck-ford-model-phase-diagram-and-corresponding-states-analysis
#11
Rodolfo Paula Leite, Pedro Antonio Santos-Flórez, Maurice de Koning
Using molecular dynamics simulations and nonequilibrium thermodynamic-integration techniques we compute the Helmholtz free energies of the body-centered-cubic (bcc), face-centered-cubic (fcc), hexagonal close-packed, and fluid phases of the Uhlenbeck-Ford model (UFM) and use the results to construct its phase diagram. The pair interaction associated with the UFM is characterized by an ultrasoft, purely repulsive pair potential that diverges logarithmically at the origin. We find that the bcc and fcc are the only thermodynamically stable crystalline phases in the phase diagram...
September 2017: Physical Review. E
https://www.readbyqxmd.com/read/29346712/synergetic-effects-of-prenatal-and-postnatal-high-sucrose-intake-on-glucose-tolerance-and-hepatic-insulin-resistance-in-rat-offspring
#12
Pengjie Zhang, Di Zhu, Yueming Zhang, Lingjun Li, Xionghui Chen, Wenna Zhang, Ruixiu Shi, Jianying Tao, Bing Han, Zhice Xu
SCOPE: High sucrose intake during pregnancy is linked to type 2 diabetes mellitus and altered insulin resistance. METHODS AND RESULTS: This study attempted to ascertain whether prenatal high sucrose intake (20% sucrose) alleviates the detrimental effects of high postnatal sugar consumption in the offspring, and the molecular mechanisms were investigated using a rat model. High prenatal sucrose exposure increased the body weight of the offspring at 1 to 3 weeks of age...
January 18, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29344871/laser-capture-microdissection-for-layer-specific-analysis-of-enteric-ganglia
#13
Corinna Rosenbaum, Martina Böttner, Thilo Wedel, Marco Metzger
The enteric nervous system (ENS) is the division of the autonomic nervous system that innervates the gastrointestinal (GI) tract and controls central intestinal functions such as peristalsis and fluid movement. Enteric nerve cell bodies (neurons and glia) are predominantly organized in ganglionated networks that are present along the entire length of the GI tract in multiple tissue layers. Most cell bodies are organized in the myenteric plexus allocated between the longitudinal and the circular muscle layers or in the submucosal plexus between muscle tissue and mucosa...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29344708/treatment-of-combined-traumatic-brain-injury-and-hemorrhagic-shock-with-fractionated-blood-products-versus-fresh-whole-blood-in-a-rat-model
#14
Akiva Leibowitz, Evgeni Brotfain, Leonid Koyfman, Moti Klein, Shmuel Hess, Alexander Zlotnik, Matthew Boyko
INTRODUCTION: Treatment of combined traumatic brain injury and hemorrhagic shock, poses a particular challenge due to the possible conflicting consequences. While restoring diminished volume is the treatment goal for hypovolemia, maintaining adequate cerebral perfusion pressure and avoidance of secondary damage remains a treatment goal for the injured brain. Various treatment modalities have been proposed, but the optimal resuscitation fluid and goals have not yet been clearly defined...
January 17, 2018: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/29344419/dendrobium-sources-of-active-ingredients-to-treat-age-related-pathologies
#15
REVIEW
Veronika Cakova, Frederic Bonte, Annelise Lobstein
Dendrobium represents one of the most important orchid genera, ornamentally and medicinally. Dendrobiums are sympodial epiphytic plants, which is a name they are worthy of, the name coming from Greek origin: "dendros", tree, and "bios", life. Dendrobium species have been used for a thousand years as first-rate herbs in traditional Chinese medicine (TCM). They are source of tonic, astringent, analgesic, antipyretic, and anti-inflammatory substances, and have been traditionally used as medicinal herbs in the treatment of a variety of disorders, such as, nourishing the stomach, enhancing production of body fluids or nourishing Yin...
December 2017: Aging and Disease
https://www.readbyqxmd.com/read/29343709/experimental-and-numerical-investigation-on-dragonfly-wing-and-body-motion-during-voluntary-take-off
#16
Qiushi Li, Mengzong Zheng, Tianyu Pan, Guanting Su
We present a detailed analysis of the voluntary take-off procedure of a dragonfly. The motions of the body and wings are recorded using two high-speed cameras at Beihang University. The experimental results show that the dragonfly becomes airborne after approximately one wingbeat and then leaves the ground. During this process, the maximum vertical acceleration could reach 20 m/s2. Evidence also shows that acceleration is generated only by the aerodynamic force induced by the flapping of wings. The dragonfly voluntary take-off procedure is divided into four phases with distinctive features...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29343314/cell-free-dna-the-role-in-pathophysiology-and-as-a-biomarker-in-kidney-diseases
#17
Peter Celec, Barbora Vlková, Lucia Lauková, Janka Bábíčková, Peter Boor
Cell-free DNA (cfDNA) is present in various body fluids and originates mostly from blood cells. In specific conditions, circulating cfDNA might be derived from tumours, donor organs after transplantation or from the foetus during pregnancy. The analysis of cfDNA is mainly used for genetic analyses of the source tissue -tumour, foetus or for the early detection of graft rejection. It might serve also as a nonspecific biomarker of tissue damage in critical care medicine. In kidney diseases, cfDNA increases during haemodialysis and indicates cell damage...
January 18, 2018: Expert Reviews in Molecular Medicine
https://www.readbyqxmd.com/read/29342932/interstitial-glucose-and-physical-exercise-in-type-1-diabetes-integrative-physiology-technology-and-the-gap-in-between
#18
REVIEW
Othmar Moser, Jane E Yardley, Richard M Bracken
Continuous and flash glucose monitoring systems measure interstitial fluid glucose concentrations within a body compartment that is dramatically altered by posture and is responsive to the physiological and metabolic changes that enable exercise performance in individuals with type 1 diabetes. Body fluid redistribution within the interstitial compartment, alterations in interstitial fluid volume, changes in rate and direction of fluid flow between the vasculature, interstitium and lymphatics, as well as alterations in the rate of glucose production and uptake by exercising tissues, make for caution when interpreting device read-outs in a rapidly changing internal environment during acute exercise...
January 15, 2018: Nutrients
https://www.readbyqxmd.com/read/29342851/laser-machining-and-in-vitro-assessment-of-wollastonite-tricalcium-phosphate-eutectic-glasses-and-glass-ceramics
#19
Daniel Sola, Lorena Grima
Bioactivity and ingrowth of ceramic implants is commonly enhanced by a suitable interconnected porous network. In this work, the laser machining of CaSiO₃‒Ca₃(PO₄)₂ biocompatible eutectic glass-ceramics and glasses was studied. For this purpose, 300 µm diameter craters were machined by using pulsed laser radiation at 532 nm with a pulsewidth in the nanosecond range. Machined samples were soaked in simulated body fluid for 2 months to assess the formation of a hydroxyapatite layer on the surface of the laser machined areas...
January 13, 2018: Materials
https://www.readbyqxmd.com/read/29342150/in-vivo-osteoconductivity-of-surface-modified-ti-29nb-13ta-4-6zr-alloy-with-low-dissolution-of-toxic-trace-elements
#20
Eri Takematsu, Kimihiro Noguchi, Kensuke Kuroda, Toshiyuki Ikoma, Mitsuo Niinomi, Nobuhiro Matsushita
Simulated Body Fluid (SBF) has served as a useful standard to check the bioactivity of implant materials for years. However, it is not perfectly able to imitate human serum; sometimes disparities between the SBF test and animal test were confirmed. Therefore, to ensure the reliability of the results of the SBF test obtained from our previous study, an animal study was performed to check osteoconductivity of surface modified implant materials. Three types of solution processes, hydrothermal (H), electrochemical (E), and hydrothermal-electrochemical (HE), were performed on the Ti-29Nb-13Ta-4...
2018: PloS One
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