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Piotr Kocełak, Aleksander Owczarek, Maria Bożentowicz-Wikarek, Aniceta Brzozowska, Małgorzata Mossakowska, Tomasz Grodzicki, Andrzej Więcek, Jerzy Chudek, Magdalena Olszanecka-Glinianowicz
PURPOSE: The aim of the study was to assess plasma RBP4 concentration in elderly subjects in relation to nutritional status and kidney function in the population of the PolSenior Study. MATERIAL AND METHODS: We assessed RBP4, glucose, insulin, albumin, lipid profile, C-reactive protein, (hsCRP) and creatinine concentrations in 2614 PolSenior Study participants (1235 women and 1379 men). The study group was divided based on BMI and HOMA-IR values, and the occurrence of diabetes...
July 16, 2018: Advances in Medical Sciences
Xia Zhao, Dan Zhang, Menglian Wu, Yang Yang, Hui Xie, Yuqin Li, Jihui Jia, Yonggang Su
Loneliness has been identified as a risk factor for depressive symptoms. Resilience and social support have been regarded as underlying protective factors. Little is known about the complex relations among these factors in the nursing home elderly. This study aimed to assess the prevalence of depressive symptoms, explore whether resilience mediated the association between loneliness and depressive symptoms, and investigate whether social support moderated the indirect or direct effect of mediation model. A total of 323 nursing home elderly were recruited in Jinan City, China...
July 9, 2018: Psychiatry Research
Man Xu, Ruoling Chen, Bing Liu, Yun Chai, Dorothy D Boer, Ping Hu, Zhi Hu
The co-morbidity of cardiovascular disease (CVD) and depression is quite frequent in old people, and some potential biological and behavioural mechanisms linking them have been reported. Yet the impact of psychosocial factors on depression in the elderly with CVD remains unclear. This study aimed to analyze the psychosocial determinants of depression in the elderly with CVD. Using the Geriatric Mental Status-Automated Geriatric Examination for Computer Assisted Taxonomy, a community-based household survey was performed in 2,199 elderly people from the Anhui cohort third-wave survey from 2007 to 2009 and an extended study in Hubei from 2010 to 2011...
March 17, 2018: Psychiatry Research
Alexandra Gogola, Ning-Jiun Jan, Bryn Brazile, Po Lam, Kira L Lathrop, Kevin C Chan, Ian A Sigal
Purpose: Collagen is the main load-bearing component of the eye, and collagen crimp is a critical determinant of tissue mechanical behavior. We test the hypothesis that collagen crimp morphology varies over the human cornea and sclera and with age. Methods: We analyzed 42 axial whole-globe sections from 20 normal eyes of 20 human donors, ranging in age from 0.08 (1 month) to 97 years. The sections were imaged using polarized light microscopy to obtain μm-scale fiber bundle/lamellae orientation from two corneal and six scleral regions...
June 1, 2018: Investigative Ophthalmology & Visual Science
Anquan Xue, Linyan Zheng, Guilin Tan, Shaoqun Wu, Yue Wu, Lingyun Cheng, Jia Qu
Purpose: Myopia has become a global public health problem, particularly in East Asia where myopic retinopathy has become one of the leading causes of blindness and visual impairment in the elderly population. The purpose of this study was to evaluate the efficacy of posterior scleral contraction/reinforcement (PSCR) surgery on controlling the progressive elongation of axial length of highly myopic eyes in young patients. Methods: This is a prospective self-controlled interventional case series...
July 2, 2018: Investigative Ophthalmology & Visual Science
Rueshandra Roosenhoff, Erhard van der Vries, Anne van der Linden, Geert van Amerongen, Koert J Stittelaar, Saskia L Smits, Martin Schutten, Ron A M Fouchier
Influenza viruses can cause severe life threatening infections in high-risk patients, including young children, the elderly and patients with compromised immunity due to underlying medical conditions or immunosuppressive treatment. The impaired immunity of these patients causes prolonged virus infection and combined with antiviral treatment facilitates the emergence of viruses with resistance mutations. The diverse nature of their immune status makes them a challenging group to study the impact of influenza virus infection and the efficacy of antiviral therapy...
2018: PloS One
Antonio Cannata', Marco Merlo, Jessica Artico, Piero Gentile, Luca Camparini, Jacopo Cristallini, Aldostefano Porcari, Francesco Loffredo, Gianfranco Sinagra
: The rapid increase in the median age of the world's population requires particular attention towards older and more fragile people. Cardiovascular risk factors, time and comorbidities play a vicious role in the development of heart failure, both with reduced and preserved ejection fraction, in the elderly. Understanding the mechanisms underlying the pathophysiological processes observed with aging is pivotal to target those patients and their therapeutic needs properly. This review aims to investigate and to dissect the main pathways leading to the aging cardiomyopathy, helping to understand the relationship from bench to bedside of the clinical phenotype...
July 17, 2018: Journal of Cardiovascular Medicine
Catherine Carey, Jacob Hodges, John K Webb
OBJECTIVES: The purpose of this paper is to summarize how state legislators are responding to the increasing incidence of elder financial fraud and exploitation (EFFE) and investigate the impact of new state legislation. METHODS: Our empirical model investigates the impact of recent changes in state legislation, after controlling for relevant state demographics, on the prevalence of EFFE claims reported in the Consumer Sentinel Network database. We use panel data in a fixed effects model with and without time dummy variables...
July 19, 2018: Journal of Elder Abuse & Neglect
Jinjiao Wang, Sandra F Simmons, Cathy A Maxwell, David G Schlundt, Lorraine C Mion
The objectives of this study were (1) to describe home health care (HHC) nurses' perception of and care processes related to geriatric depression and frailty, and (2) to identify barriers to care delivery for older persons with these two conditions. Ten semi-structured interviews were conducted with HHC nurses, and 16 HHC nursing visits to 16 older patients (≥65 years) were observed. Mixed method analysis showed that HHC nurses did not routinely assess for frailty and depression. Major barriers to care delivery included insufficient training, documentation burden, limited reimbursement, and high caseload...
July 2018: Journal of Community Health Nursing
Paolo E Puddu
No abstract text is available yet for this article.
January 1, 2018: European Journal of Preventive Cardiology
Karen L Margolis, Suzanne E Mahady, Mark R Nelson, Diane G Ives, Suzanne Satterfield, Carlene Britt, Saifuddin Ekram, Jessica Lockery, Erin C Schwartz, Robyn L Woods, John J McNeil, Erica M Wood
Background: Bleeding is the major risk of aspirin treatment, especially in the elderly. A consensus definition for clinically significant bleeding (CSB) in aspirin primary prevention trials is lacking in the literature. Methods: This paper details the development, modification, application, and quality control of a definition for clinically significant bleeding in the ASPirin in Reducing Events in the Elderly (ASPREE) trial, a primary prevention trial of aspirin in 19,114 community-dwelling elderly men and women...
September 2018: Contemporary Clinical Trials Communications
Hao Yan, Zheyuan Ding, Juying Yan, Wenwu Yao, Junhang Pan, Zhangnv Yang, Xiuyu Lou, Haiyan Mao, Junfen Lin, Jimin Sun, Juan Hou, Haocheng Wu, Chen Wu, Yanjun Zhang
Dengue, a mosquito-borne disease caused by the dengue virus (DV), has been recognized as a global public health threat. In 2017, an unexpected dengue outbreak occurred in Zhejiang, China. To clarify and characterize the causative agent of this outbreak, data on dengue fever cases were collected from the China Information System for Disease Control and Prevention in Zhejiang province for subsequent epidemiological analysis. A total of 1,229 cases were reported, including 1,149 indigenous and 80 imported cases...
2018: Frontiers in Cellular and Infection Microbiology
Kenji Watanabe, Kenji Yamada, Koji Sameshima, Seiji Yamaguchi
Introduction: Very long-chain acyl-CoA dehydrogenase (VLCAD) deficiency is an autosomal recessive mitochondrial fatty acid oxidation disorder and presents as hypoketotic hypoglycemia or rhabdomyolysis during childhood. l-Carnitine supplementation for patients with VLCAD deficiency is controversial. Herein, we describe two siblings with VLCAD deficiency who experienced more frequent episodes of rhabdomyolysis after l-carnitine supplementation. Case presentation: Case 1 involved a 6-year-old boy who was diagnosed with VLCAD deficiency after repeated episodes of hypoketotic hypoglycemia at 3 years of age...
June 2018: Molecular Genetics and Metabolism Reports
Carles Falcon, Alan Tucholka, Gemma C Monté-Rubio, Raffaele Cacciaglia, Grégory Operto, Lorena Rami, Juan Domingo Gispert, José Luis Molinuevo
Alzheimer's disease (AD) is characterized by an accumulation of β-amyloid (Aβ42 ) accompanied by brain atrophy and cognitive decline. Several recent studies have shown that Aβ42 accumulation is associated with gray matter (GM) changes prior to the development of cognitive impairment, in the so-called preclinical stage of the AD (pre-AD). It also has been proved that the GM atrophy profile is not linear, both in normal ageing but, especially, on AD. However, several other factors may influence this association and may have an impact on the generalization of results from different samples...
2018: NeuroImage: Clinical
Tadesse M Abegaz, Ousman A Abdela, Akshaya S Bhagavathula, Fitsum S Teni
Background: Hypertension is an important public health problem worldwide. There is lack of data on uncontrolled blood pressure in developing countries. Objectives: To determine the magnitude and predicting factors of uncontrolled blood pressure in hypertensive patients attending Gondar university hospital, Ethiopia. Methods: A hospital-based cross-sectional survey was conducted from July 2015 to March 2016. All hypertensive patients were followed and the blood pressure levels were measured...
April 2018: Pharmacy Practice
Apichat Kaewdech, Pimsiri Sripongpun
Phlegmonous proctitis is a rare condition; it was first described in 1940. We report the case of an elderly woman who presented with acute severe lower abdominal pain, tenesmus, and fever. A computed tomography of the whole abdomen revealed a long segment of circumferential wall thickening of the rectum and rectosigmoid colon. Colonoscopy was done subsequently and showed marked edematous and erythematous rectal mucosa. When rectal tissue biopsy was performed, a large amount of pus came out at the biopsy site, which led to the diagnosis of phlegmonous proctitis...
May 2018: Case Reports in Gastroenterology
Emilie Aubry, Natalie Friedli, Philipp Schuetz, Zeno Stanga
Aging is linked to physiological and pathophysiological changes. In this context, elderly patients often are frail, which strongly correlates with negative health outcomes and disability. Elderly patients are often malnourished, which again is an independent risk factor for both frailty and adverse clinical outcomes. Malnutrition and resulting frailty can be prevented by adequate nutritional interventions. Yet, use of nutritional therapy can also have negative consequences, including a potentially life-threatening metabolic alteration called refeeding syndrome (RFS) in high-risk patients...
2018: Clinical and Experimental Gastroenterology
Hua Xu, Yaping Wang, Yefeng Yuan, Xulai Zhang, Xiaoyun Zuo, Lijuan Cui, Ying Liu, Wei Chen, Ning Su, Haihong Wang, Feng Yan, Xia Li, Tao Wang, Shifu Xiao
Background: Gender differences may contribute to variances in the potential protective effects of tea against cognitive impairment in the elderly. Objective: To examine the association between different types of tea consumption and the risk of amnestic mild cognitive impairment (aMCI) along gender lines. Methods: A cross-sectional study was conducted with reference to 20 communities in China. The sample population included elderly participants aged 60 years or older...
2018: Neuropsychiatric Disease and Treatment
Ayse Ferdane Oguzoncul, Emel Ercan, Evrim Celebi
Objective: As our society ages, the incidence of acute and chronic diseases increases, and so does chronic drug use and polypharmacy. This study was intended to examine the medication behaviors of the elderly who lived in the nursing homes in the Elazig and Malatya provinces, located in eastern Turkey, and in the Kayseri province located in Central Anatolia. Materials and methods: The population of this cross-sectional study included people over the age of 60 years (n=310) who lived in the nursing homes in the Elazig, Malatya, and Kayseri provinces...
2018: Clinical Interventions in Aging
Dan Yu, Fu-Min Zhao, Xiao-Tang Cai, Hui Zhou, Yan Cheng
Early-onset progressive encephalopathy is a lethal encephalopathy caused by NAXE gene mutations. This paper reports the clinical and genetic features of a patient with early-onset progressive encephalopathy. A 4-year-old boy admitted to the hospital had repeated walking instability and limb weakness for 2 years. The patient and his elder brother (already dead) had clinical onset at 2 years of age. Both of them showed symptoms such as strabismus, ataxia, reduced muscle tone, delayed development, and repeated respiratory failure after infection...
July 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
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