keyword
https://read.qxmd.com/read/38493328/colporrhaphies-versus-colpocleisis-following-vaginal-hysterectomy-for-the-treatment-of-advanced-pelvic-organ-prolapse-a-comparative-study
#1
JOURNAL ARTICLE
Eiman Shalabna, Nir Haya, Ariel Zilberlicht, Rotem Sadeh, Yoram Abramov
BACKGROUND: Obliterative vaginal procedures may offer lower perioperative morbidity and equal success rates as reconstructive procedures for frail and elderly women who no longer desire future coital function. The combination of vaginal hysterectomy with either reconstructive or obliterative vaginal procedures has not yet been investigated. OBJECTIVES: To compare peri- and postoperative outcomes of vaginal hysterectomy with pelvic floor reconstruction (VHR) vs. vaginal hysterectomy with colpocleisis (VHC)...
March 2024: Israel Medical Association Journal: IMAJ
https://read.qxmd.com/read/38493271/evaluation-of-the-relationship-of-treatment-and-vaccination-with-prognosis-in-patients-with-a-diagnosis-of-covid-19
#2
JOURNAL ARTICLE
Seyma Oncu, Derya Korkmaz
PURPOSE: Coronavirus disease 2019 (COVID-19) has affected millions of people worldwide and caused mortality. Many factors have been reported to affect the prognosis of COVID-19. In this study, we aimed to investigate the effects of drug therapy and vaccination on prognosis in patients hospitalized with a COVID-19 diagnosis. METHODS: In this single-center, cross-sectional study, data were retrospectively collected from patients receiving inpatient treatment at a university hospital with a diagnosis of COVID-19 between January 1, 2020, and April 30, 2022...
March 16, 2024: Inflammopharmacology
https://read.qxmd.com/read/38493090/involvement-of-fgf2-mediated-tau-protein-phosphorylation-in-cognitive-deficits-induced-by-sevoflurane-in-aged-rats
#3
JOURNAL ARTICLE
Xin Xie, Xiaomin Zhang, Songze Li, Wei Du
OBJECTIVE: Anesthetics have been linked to cognitive alterations, particularly in the elderly. The current research delineates how Fibroblast Growth Factor 2 (Fgf2) modulates tau protein phosphorylation, contributing to cognitive impairments in aged rats upon sevoflurane administration. METHODS: Rats aged 3, 12, and 18 months were subjected to a 2.5% sevoflurane exposure to form a neurotoxicity model. Cognitive performance was gauged, and the GEO database was employed to identify differentially expressed genes (DEGs) in the 18-month-old cohort post sevoflurane exposure...
March 16, 2024: Molecular Medicine
https://read.qxmd.com/read/38493076/metabolic-reprogramming-in-the-cll-tme-potential-for-new-therapeutic-targets
#4
JOURNAL ARTICLE
Helga Simon-Molas, Chiara Montironi, Anna Kabanova, Eric Eldering
Chronic lymphocytic leukemia (CLL) cells circulate between peripheral (PB) blood and lymph node (LN) compartments, and strictly depend on microenvironmental factors for proliferation, survival and drug resistance. All cancer cells display metabolic reprogramming and CLL is no exception - though the inert status of the PB CLL cells has hampered detailed insight into these processes. We summarize previous work on reactive oxygen species (ROS), oxidative stress, and hypoxia, as well as the important roles of Myc, and PI3K/Akt/mTor pathways...
February 15, 2024: Seminars in Hematology
https://read.qxmd.com/read/38493053/prurigo-review-of-its-pathogenesis-diagnosis-and-treatment
#5
REVIEW
Paulo Ricardo Criado, Mayra Ianhez, Roberta Fachini Jardim Criado, Juliana Nakano, Daniel Lorenzini, Hélio Amante Miot
Prurigo is a reactive, hyperplastic skin condition characterized by pruritic papules, plaques, and/or nodules. The temporal classification includes acute/subacute and chronic disease (≥ 6 weeks), with different clinical variants, synonymies, and underlying etiological factors. The immunology of chronic prurigo shows similarities with atopic dermatitis due to the involvement of IL-4 and IL-13, IL-22, and IL-31. Treatment includes antihistamines, topical steroids, dupilumab, and JAK inhibitors. Several conditions manifest clinically as prurigo-like lesions, and the correct clinical diagnosis must precede correct treatment...
March 16, 2024: Anais Brasileiros de Dermatologia
https://read.qxmd.com/read/38492924/cost-effectiveness-of-two-models-of-pessary-care-for-pelvic-organ-prolapse-findings-from-the-topsy-randomised-controlled-trial
#6
JOURNAL ARTICLE
Sarkis Manoukian, Helen Mason, Suzanne Hagen, Rohna Kearney, Kirsteen Goodman, Catherine Best, Andrew Elders, Lynn Melone, Lucy Dwyer, Melanie Dembinsky, Aethele Khunda, Karen Lesley Guerrero, Doreen McClurg, John Norrie, Ranee Thakar, Carol Bugge
OBJECTIVES: Pelvic organ prolapse is the descent of one or more reproductive organs from their normal position, causing associated negative symptoms. One conservative treatment option is pessary management. The aim of this study was to investigate the cost-effectiveness of pessary self-management (SM) when compared to clinic-based care (CBC). A decision-analytic model was developed to extend the economic evaluation. METHODS: A randomised controlled trial with health economic evaluation...
March 14, 2024: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://read.qxmd.com/read/38492615/the-impact-of-frailty-as-a-critical-mediator-causing-postoperative-neurocognitive-disorders-in-postoperative-cardiac-patients
#7
REVIEW
Hu Li, Jinfeng Li, Xin Huang, Bhushan Sandeep, Jing Yang
Frailty is prevalent in elderly cardiac patients and may be a critical predictor of post-operative neurocognitive disorders (PND). The aim of this review was to demonstrate the correlation of frailty with PND in postsurgical elder patients. A review of published literature and bibliometric analysis was undertaken. Electronic databases from 2009 to 2022 were searched to identify articles that evaluated the relationship between frailty and PND in aging populations. Demographic data, type of surgery performed, frailty measurement, and impact of frailty on PND were extracted from the selected studies...
March 14, 2024: Current Problems in Cardiology
https://read.qxmd.com/read/38492114/improved-survival-over-time-with-immunotherapy-in-locally-advanced-and-metastatic-cutaneous-squamous-cell-carcinomas
#8
JOURNAL ARTICLE
Sophie Schneider, Thomas Ferte, Océane Ducharme, Léa Dousset, Sorilla Prey, Caroline Dutriaux, Emilie Gerard, Marie Beylot-Barry, Anne Pham-Ledard
PURPOSE: Cutaneous squamous cell carcinoma (cSCC) is the second most common cancer in white-skinned populations. There is little information on the epidemiology of cSCC, and even less on advanced cases (acSCC). Therefore, we analyzed acSCC patients to describe their characteristics, management, and outcomes over time. METHODS: A single-center retrospective study was conducted over a period of 5 years, including all patients who started systemic therapy for acSCC...
March 16, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38491923/triceps-tendon-reattachment-using-mini-plates-and-screws-after-failure-of-olecranon-avulsion-fracture-fixation-in-osteoporotic-bone-a-case-report
#9
JOURNAL ARTICLE
Nicholas B Pohl, Parker L Brush, James Russo, Sebastian I Fras, Pedro K Beredjiklian, Daniel J Fletcher
This is a case report of an 85-year-old woman with osteopenia who underwent olecranon avulsion fracture repair with supplemental triceps tendon repair following a fall on an outstretched arm. The initial procedure failed due to osteoporotic bone quality and an atraumatic disruption of the olecranon fracture fixation. The patient subsequently underwent further surgical intervention with an olecranon avulsion fracture excision and a novel triceps tendon repair technique using plate augmentation and fiber tape...
March 16, 2024: Hand: Official Journal of the American Association for Hand Surgery
https://read.qxmd.com/read/38491876/orem-s-self-care-model-of-nursing-care-a-retrospective-study-with-elders-after-hip-arthroplasty
#10
JOURNAL ARTICLE
Huixin Zhu, Mengqiang You, Jie Wei, Shanhong Fang
This retrospective study investigates the effectiveness of a nursing intervention based on Orem's self-care model of nursing with elderly patients with femoral head necrosis who underwent total hip arthroplasty. Postoperative outcomes in the intervention and control groups were assessed by the visual analog scale (VAS), Barthel index, and Harris Hip Score (HHS). Participants in the intervention group had significantly better outcomes in terms of VAS, Barthel index, and HHS. The occurrence of pneumonia was significantly different between the groups...
April 2024: Nursing Science Quarterly
https://read.qxmd.com/read/38491543/a-retrospective-study-exploring-preoperative-hyponatremia-in-elderly-patients-with-hip-fractures
#11
JOURNAL ARTICLE
Li-Tao Shi, Zhen Feng, Cui-Min Zhu
BACKGROUND: This research aims to examine the frequency, age-related distribution, and intensity of preoperative hyponatremia among elderly individuals with hip fractures. This study aims to provide valuable insights into the diagnosis of preoperative hyponatremia in this patient population. METHODS: This research involved the analysis of clinical data obtained from 419 elderly individuals with hip fractures (referred to as the fracture group) and 166 elderly individuals undergoing routine health examinations (designated as the control group)...
March 16, 2024: Journal of Orthopaedic Surgery and Research
https://read.qxmd.com/read/38491518/serological-investigation-and-isolation-of-salmonella-abortus-equi-in-horses-in-xinjiang
#12
JOURNAL ARTICLE
Zhanhai Mai, Han Fu, Ronghao Miao, Chong Lu, Xiaosong Zhang, Ziwen Yuan, Peng Ji, Yongli Hua, Chen Wang, Yuhui Ma, Haifeng Deng, Yanming Wei
BACKGROUND: Salmonella enterica subspecies enterica serovar abortus equi (S. abortus equi) is one of the main pathogens that causes abortion in pregnant horses and donkeys, which was highly infectious and greatly restricts the healthy development of the horse industry. OBJECTIVES: In order to investigate the prevalence and biological characteristics of S. abortus equi in different regions and breeds of horses in Xinjiang. METHODS: This study conducted ELISA detection of S...
March 15, 2024: BMC Veterinary Research
https://read.qxmd.com/read/38491436/objectively-measured-the-impact-of-ambient-air-pollution-on-physical-activity-for-older-adults
#13
JOURNAL ARTICLE
Jiali Cheng, Yin Wu, Xiaoxin Wang, Hongjun Yu
BACKGROUND: Air pollution poses a significant health risk to the human population, especially for vulnerable groups such as the elderly, potentially discouraging their engagement in physical activity. However, there is a lack of sufficient objective and longitudinal data in current research on how air pollution affects physical activity among older adults. With these gaps, we aimed to explore the relationship between air pollution and objective measurement-based physical activity among older adults by engaging in a longitudinal study design...
March 15, 2024: BMC Public Health
https://read.qxmd.com/read/38491396/the-impact-of-the-covid-19-pandemic-on-neurosurgery-in-the-elderly-population-in-sweden
#14
JOURNAL ARTICLE
Michael Axenhus, Sophia Schedin-Weiss, Lars Tjernberg, Bengt Winblad
BACKGROUND: The COVID-19 pandemic prompted a refocus of health care resources to acute care which has impacted on the capacity of healthcare systems to conduct neurological surgeries. The elderly population has been shown to be particularly vulnerable to the consequences of the pandemic. Less neurosurgery can result in great impact on public health by increasing morbidity and mortality in patients with malignancies and traumatic injuries. The aim of this study was to investigate the effects of the COVID-19 pandemic on neurosurgical procedures in the elderly population in Sweden...
March 15, 2024: BMC Public Health
https://read.qxmd.com/read/38491218/preoperative-elastoplasty-of-aggressive-vertebral-hemangiomas-in-elderly-patients-a-new-strategy-for-reducing-intraoperative-bleeding-and-complications
#15
JOURNAL ARTICLE
Giorgio Lofrese, Francesco Cultrera, Luca Ricciardi, Jacopo Visani, Luigino Tosatto, Maria Ruggiero, Nicolò Haznedari, Federico Menetti
PURPOSE: Preoperative elastoplasty could be an alternative strategy for treating aggressive vertebral hemangiomas (VHs) in frail patients needing for spinal cord decompression, combining the advantages of embolization and vertebroplasty. METHODS: Three elderly patients with spinal cord compression from thoracic aggressive VHs underwent XperCT-guided percutaneous injection of silicone (VK100), filling the whole affected vertebra, followed by a decompressive laminectomy...
March 15, 2024: European Spine Journal
https://read.qxmd.com/read/38491173/prognostic-factors-of-renal-cell-cancer-in-elderly-patients-a-population-based-cohort-study
#16
JOURNAL ARTICLE
Heini Pajunen, Thea Veitonmäki, Heini Huhtala, Jussi Nikkola, Antti Pöyhönen, Teemu Murtola
Mortality in renal cell cancer (RCC) is high in the elderly population. Comorbidities have a greater impact on overall prognosis of RCC among elderly patients than in younger patients. All new RCC cases were collected in people over 74 years of age between 1995 and 2018 from the Finnish cancer registry. The comorbidities were identified from the Care Registry for Healthcare. Charlson Comorbidity Index (CCI) was used to evaluate the risk of death based on comorbidities. The overall risk of death was analyzed using the Cox regression model...
March 15, 2024: Scientific Reports
https://read.qxmd.com/read/38491120/a-large-cross-sectional-study-on-diaper-utilization-and-beneficial-role-in-outdoor-activity-and-emotions-among-incontinence-elderly-people
#17
JOURNAL ARTICLE
Yunwei Zhang, Dawei Fang, Yashuang Luo, Changying Wang, Lingshan Wan, Yifan Cao, Hongyun Xin, Hansheng Ding
This study was designed based on a cross-sectional investigation conducted Shanghai, China. Demographic characteristics, diaper utilization, Activities of Daily Living (ADL) and emotion were collected by Unified Needs Assessment Form for Elderly Care Questionnaire. Cognition function was assessed by Mini-mental State Examination (MMSE) scale. Multivariate logistic regression was used for statistical analysis. The diaper utilization rate was 31.2%. Female, higher level of education, poorer ADL and cognition, more severe incontinence and financial dependence on others were facilitating factors for diaper usage (P < 0...
March 16, 2024: Scientific Reports
https://read.qxmd.com/read/38491039/reliable-relay-assisted-communications-for-iot-based-fall-detection
#18
JOURNAL ARTICLE
Khulud K Alharbi, Sajid H Alvi, Bakhtiar Ali, Jawad Mirza, Muhammad Awais Javed, Hatem A Alharbi
Robust wireless communication using relaying system and Non-Orthogonal Multiple Access (NOMA) will be extensively used for future IoT applications. In this paper, we consider a fall detection IoT application in which elderly patients are equipped with wearable motion sensors. Patient motion data is sent to fog data servers via a NOMA-based relaying system, thereby improving the communication reliability. We analyze the average signal-to-interference-plus-noise (SINR) performance of the NOMA-based relaying system, where the source node transmits two different symbols to the relay and destination node by employing superposition coding over Rayleigh fading channels...
March 15, 2024: Scientific Reports
https://read.qxmd.com/read/38490851/functional-outcome-and-associations-with-prehospital-time-and-urban-remote-disparities-in-trauma-a-norwegian-national-population-based-study
#19
JOURNAL ARTICLE
Imw Nilsbakken, T Wisborg, S Sollid, E Jeppesen
BACKGROUND: There is a lack of knowledge regarding the functional outcomes of patients after trauma. Remote areas in Norway has been associated with an increased risk of trauma-related mortality. However, it is unknown how this might influence trauma-related morbidity. The aim of this study was to assess the functional outcomes of patients in the Norwegian trauma population and the relationship between prehospital time and urban-remote disparities on functional outcome. METHODS: This registry-based study included 34,611 patients from the Norwegian Trauma Registry from 2015 - 2020...
March 5, 2024: Injury
https://read.qxmd.com/read/38490701/anti-interleukin-6-receptor-antibody-for-the-treatment-of-remitting-seronegative-symmetrical-synovitis-with-pitting-oedema-a-new-outlook
#20
JOURNAL ARTICLE
Rita Noversa de Sousa, Diana Marques Rocha, Marisa Nair Simões, Cristina Rosário
We present the case of an elderly man with a small-joint polyarthritis, accompanied by pitting oedema, involving hands and feet, raising clinical suspicion of remitting seronegative symmetrical synovitis with pitting oedema (RS3PE). Treatment with corticosteroids was initiated with significant improvement, but unacceptable iatrogeny ensued, and tapering was not possible without disease flare-up. A trial of tocilizumab allowed disease activity control, slow weaning of corticosteroids and, ultimately, its suspension...
March 15, 2024: BMJ Case Reports
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