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https://www.readbyqxmd.com/read/29356356/phase-angle-measured-by-electrical-bioimpedance-and-global-cardiovascular-risk-in-older-adults
#1
Maria An Saad, Antonio Jl Jorge, Wolney de Andrade Martins, Gilberto P Cardoso, Marcia Ms Dos Santos, Maria Lg Rosa, Giovanna Ab Lima, Rafaela Q de Moraes, Rubens A da Cruz Filho
AIM: Population aging is a worldwide phenomenon associated with physiological and metabolic changes that contribute to the increased prevalence of risk factors for cardiovascular disease. The phase angle (PA) is a variable calculated by bioelectrical impedance analysis, interpreted as a direct measure of cell stability. The objective of the present study was to investigate the correlation of PA with the anthropometric measures, metabolic profile and the cardiovascular risk estimated by the Global Cardiovascular Risk Score in the elderly population...
January 22, 2018: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/29356011/the-right-side-perceptual-bias-in-aging-determined-in-a-laboratory-setting-and-during-a-virtual-driving-task
#2
Heikki Hämäläinen, Faramosh Rashid Izullah, Mika Koivisto, Fiia Takio, Mika Luimula
Spatial perceptual rightward bias which was originally described in Dichotic Listening studies seems to be a general phenomenon. This bias is age dependent, being evident in children with developing executive functions, and emerging again at older age as a function of aging and the declining executive functions. In the two studies presented here we compared the performance of young and elderly adults in spatial divided attention tasks with auditory and visual stimuli when the stimulus detection performance was measured in separate sessions in a laboratory setting (Study I), to performance when the same types of stimuli were mixed with a task in which the subject's primary objective was to drive a car in a virtual environment (virtual reality; Study II)...
February 2018: Scandinavian Journal of Psychology
https://www.readbyqxmd.com/read/29355917/radiotherapy-regimens-in-patients-with-nonmelanoma-head-and-neck-skin-cancers
#3
Yusuf Dundar, Richard B Cannon, Jason P Hunt, Marcus Monroe, Gita Suneja, Ying J Hitchcock
BACKGROUND: To assess the effectiveness and outcomes of adjuvant radiotherapy regimens for nonmelanoma skin cancers (NMSC) of the head and neck, particularly for elderly patients. METHODS: A retrospective review of patients with head and neck NMSC was conducted. Radiotherapy dose per fraction regimens included ≤200, 240-250, 300-400, and 500-600 cGy. Demographics, tumor characteristics, local control (LC), regional control (RC), and survival outcomes were analyzed...
January 22, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29355811/preoperative-hemoglobin-level-is-associated-with-increased-healthcare-utilization-after-elective-spinal-fusion-%C3%A2-3-levels-in-elderly-male-spine-deformity-patients
#4
Aladine A Elsamadicy, Owoicho Adogwa, Michael Ongele, Amanda R Sergesketter, Aaron Tarnasky, David E T Lubkin, Nicolas Drysdale, Joseph Cheng, Carlos A Bagley, Isaac O Karikari
BACKGROUND: Measures of healthcare utilization such as length of hospital stay (LOS) are used as proxies for quality of care after spine surgery. Accordingly, hospitals and health systems are investing considerable resources into the pre-operative identification of patients at risk for prolonged LOS. This study aims to investigate the impact of preoperative hemoglobin on outcomes and LOS after spinal fusion. METHODS: The medical records of 204 elderly (≥60 years) male patients undergoing elective spinal fusion (≥3 levels) at a major academic institution from 2005 to 2015 were reviewed...
January 17, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29355791/relationships-between-vitamin-d-and-paraspinal-muscle-human-data-and-experimental-rat-model-analysis
#5
Woo-Seok Bang, Dong-Hyun Lee, Kyoung-Tae Kim, Dae-Chul Cho, Joo-Kyung Sung, In-Bo Han, Du-Hwan Kim, Brian K Kwon, Chi Heon Kim, Ki-Su Park, Man-Kyu Park, Sung-Young Seo, Ye-Jin Seo
BACKGROUND CONTEXT: Vitamin D deficiency (VDD) has been closely linked with skeletal muscle atrophy in many studies, but to date no study has focused on paraspinal muscle. PURPOSE: To verify paraspinal muscle changes according to serum vitamin D level. STUDY DESIGN: A cross-sectional study of patients who visited our hospital and an in vivo animal study METHODS: We measured serum vitamin D concentration in 91 elderly women and stratified them according to their vitamin D status in three groups: control, vitamin D insufficiency, and VDD, and obtained magnetic resonance imaging data of the lumbar spine and evaluated the quality and quantity of the paraspinal muscles...
January 16, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29355648/impaired-awareness-of-action-outcome-contingency-and-causality-during-healthy-ageing-and-following-ventromedial-prefrontal-cortex-lesions
#6
Claire O'Callaghan, Matilde M Vaghi, Berit Brummerloh, Rudolf N Cardinal, Trevor W Robbins
Detecting causal relationships between actions and their outcomes is fundamental to guiding goal-directed behaviour. The ventromedial prefrontal cortex (vmPFC) has been extensively implicated in computing these environmental contingencies, via animal lesion models and human neuroimaging. However, whether the vmPFC is critical for contingency learning, and whether it can occur without subjective awareness of those contingencies, has not been established. To address this, we measured response adaption to contingency and subjective awareness of action-outcome relationships in individuals with vmPFC lesions and healthy elderly subjects...
January 17, 2018: Neuropsychologia
https://www.readbyqxmd.com/read/29355555/phosphodiesterase-3-inhibitor-cilostazol-reverses-endothelial-dysfunction-with-ageing-in-rat-mesenteric-resistance-arteries
#7
Hicla S Moreira, Geórgia A Lima-Leal, Juliana Santos-Rocha, Leonardo Gomes-Pereira, Gloria P Duarte, Fabiano E Xavier
Ageing impairs endothelial function, which is considered a hallmark of the development of cardiovascular diseases in elderly. Cilostazol, a phosphodiesterase-3 inhibitor, has antiplatelet, antithrombotic and protective effects on endothelial cells. Here, we hypothesized that cilostazol could improve endothelial function in mesenteric resistance arteries (MRA) from old rats. Using eight-week cilostazol-treated (100mg/kg/day) or untreated 72-week-old Wistar rats, we evaluate the relaxation to acetylcholine, sodium nitroprusside (SNP), forskolin and isoproterenol and the noradrenaline-induced contraction in MRA...
January 17, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29355479/mutations-in-l-type-amino-acid-transporter-2-support-slc7a8-as-a-novel-gene-involved-in-age-related-hearing-loss
#8
Meritxell Espino Gaurch, Mariona Font-Llitjós, Silvia Murillo-Cuesta, Ekaitz Errasti-Murugarren, Adelaida M Celaya, Giorgia Girotto, Dragana Vuckovic, Massimo Mezzavilla, Clara Vilches, Susanna Bodoy, Ignasi Sahún, Laura González, Esther Prat, Antonio Zorzano, Mara Dierssen, Isabel Varela-Nieto, Paolo Gasparini, Manuel Palacín, Virginia Nunes
Age related hearing loss (ARHL) is the most common sensory deficit in the elderly. The disease has a multifactorial etiology with both environmental and genetic factors involved being largely unknown. SLC7A8/SLC3A2 heterodimer is a neutral amino acid exchanger. Here, we demonstrated that SLC7A8 is expressed in the mouse inner ear and that its ablation resulted in ARHL, due to the damage of different cochlear structures. These findings make SLC7A8 transporter a strong candidate for ARHL in humans. Thus, a screening of a cohort of ARHL patients and controls was carried out revealing several variants in SLC7A8, whose role was further investigated by in vitro functional studies...
January 22, 2018: ELife
https://www.readbyqxmd.com/read/29355441/ntprobnp-and-st2-as-predictors-for-all-cause-and-cardiovascular-mortality-in-elderly-patients-with-symptoms-suggestive-for-heart-failure
#9
Kurt Boman, Finn Thormark Fröst, Ann-Charlotte R Bergman, Mona Olofsson
BACKGROUND: A new biomarker, suppression of tumorigenicity 2 (ST2) has been introduced as a marker for fibrosis and hypertrophy. Its clinical value in comparison with NTproBNP in predicting mortality in elderly patients with symptoms of heart failure (HF) is still unclear. AIM: To evaluate the prognostic value for all-cause- and cardiovascular mortality of ST2 or NTproBNP and secondly; the combination of these biomarkers. PATIENTS AND METHODS: 170 patients with clinical symptoms of HF of whom 77 (45%) with verified HF were recruited from one selected primary health care centre (PHC) in Sweden and echocardiography was performed in all patients...
January 22, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29355169/sex-and-gender-disparities-in-the-epidemiology-and-outcomes-of-chronic-kidney-disease
#10
REVIEW
Juan Jesus Carrero, Manfred Hecking, Nicholas C Chesnaye, Kitty J Jager
Improved understanding of sex and gender-specific differences in the aetiology, mechanisms and epidemiology of chronic kidney disease (CKD) could help nephrologists better address the needs of their patients. Population-based studies indicate that CKD epidemiology differs by sex, affecting more women than men, especially with regard to stage G3 CKD. The effects of longer life expectancy on the natural decline of glomerular filtration rate (GFR) with age, as well as potential overdiagnosis of CKD through the inappropriate use of GFR equations, might be in part responsible for the greater prevalence of CKD in women...
January 22, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29355167/preoperative-bowel-preparation-complicated-by-lethal-hypermagnesaemia-and-acute-nephropathy
#11
Olumuyiwa A Bamgbade
Hypermagnesaemia is an uncommon but serious disorder. An elderly woman presented with severe cardiovascular collapse, neurologic depression and acute nephropathy, following bowel preparation. Urgent laboratory tests revealed serum magnesium level of 7.5 mmol/L (normal = 0.75-1.05 mmol/L). Prompt resuscitation and treatment of the hypermagnesaemia included intravenous calcium chloride as a physiological antagonist, fluid infusion and frusemide to aid renal excretion of magnesium. There are few case reports of patients who survived hypermagnesaemia levels >7 mmol/L...
October 2017: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29354611/corrigendum-correction-of-the-first-author-s-affiliation-outcome-of-colorectal-surgery-in-elderly-populations
#12
Mostafa Shalaby, Nicola Di Lorenzo, Luana Franceschilli, Federico Perrone, Giulio P Angelucci, Silvia Quaresima, Achille L Gaspari, Pierpaolo Sileri
[This corrects the article on p. 139 in vol. 32, PMID: 27626024.].
December 2017: Annals of Coloproctology
https://www.readbyqxmd.com/read/29354609/side-to-side-ileosigmoidostomy-shunting-surgery-for-the-treatment-of-elderly-patients-with-chronic-constipation
#13
Yuda Handaya, Agung Maryanto, Marijata
Constipation is a digestive disorder that often occurs in the elderly; its main cause is bowel motility disorder. Treatments for patients with chronic constipation include pharmacotherapy, diet changes, and surgery if other therapies do not offer satisfactory results. We describe 4 patients, 2 men (70 and 65 years old) and 2 women (75 and 66 years old), who were diagnosed with chronic constipation (slow transit constipation) and treated with conventional therapy, but did not improve. For that reason, side-to-side ileosigmoidostomy shunting surgery was performed...
December 2017: Annals of Coloproctology
https://www.readbyqxmd.com/read/29354586/bulbar-myasthenia-gravis-superimposed-in-a-medullary-infarction-diagnosed-by-a-fiberoptic-endoscopic-evaluation-of-swallowing-with-simultaneous-tensilon-application
#14
Sung-Jun Kim, Geun-Young Park, Yong-Min Choi, Dong-Gyun Sohn, Sae-Rom Kang, Sun Im
In the elderly, myasthenia gravis (MG) can present with bulbar symptoms, which can be clinically difficult to diagnose from other neurological comorbid conditions. We describe a case of a 75-year-old man who had been previously diagnosed with dysphagia associated with medullary infarction but exhibited aggravation of the dysphagia later on due to a superimposed development of bulbar MG. After recovering from his initial swallowing difficulties, the patient suddenly developed ptosis, drooling, and generalized weakness with aggravated dysphagia...
December 2017: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29354582/the-differences-in-cardiac-rehabilitation-outcomes-by-age-in-myocardial-infarction-a-preliminary-study
#15
Hyun Ho Kong, Heui Je Bang, Jae Ung Ko, Goo Joo Lee
Objective: To determine the age-related changes in cardiac rehabilitation (CR) outcomes, which includes hemodynamic and metabolic factors, in patients with myocardial infarction (MI). Methods: CR was administered for 8 weeks to 32 men (mean age, 54.0±8.8 years) who underwent percutaneous coronary intervention for acute MI between July 2012 and January 2016. The exercise tolerance tests were performed before and after the CR. The results were stratified based on a cut-off age of 55 years...
December 2017: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29354577/effects-of-nutritional-status-on-6-month-outcome-of-hip-fractures-in-elderly-patients
#16
Ka Ying Doris Miu, Pui Shan Lam
Objective: To identify the prevalence of malnutrition in elderly hip fracture and to investigate the relationship between hip fracture patients and malnutrition on functional recovery and mortality. Methods: All hip fracture patients age >65 years admitted to a rehabilitation unit were recruited from July 2015 to June 2016. Nutritional status was assessed by Mini-Nutritional Assessment Short-Form (MNA-SF) within 72 hours of admission. Patients were reassessed at 6 months for functional status and place of residence...
December 2017: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29354226/cardiovascular-risk-factors-and-cognitive-performance-in-aging
#17
Juliana Rumy Tsuchihashi Takeda, Tatiane Martins Matos, Juliana Nery de Souza-Talarico
Background: Atherosclerosis in cerebral blood vessels, especially those which compose the Circle of Willis, can lead to reduced supply of oxygen and nutrients to different cortical structures, affecting cognitive function. Objective: To analyze whether cardiovascular risk factors negatively influence cognitive performance in adults and elderly. Methods: One hundred twenty-nine participants of both sexes, aged over 50 years, without cognitive or functional impairment were included...
October 2017: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29354222/verbal-fluency-in-elderly-with-and-without-hypertension-and-diabetes-from-the-fibra-study-in-ermelino-matarazzo
#18
Nathalia Lais Morelli, Meire Cachioni, Andrea Lopes, Samila Sathler Tavares Batistoni, Deusivania Vieira da Silva Falcão, Anita Liberalesso Neri, Monica Sanches Yassuda
Background: There are few studies on the qualitative variables derived from the animal category verbal fluency test (VF), especially with data originating from low-income samples of community-based studies. Objective: To compare elderly with and without hypertension (HTN) and diabetes mellitus (DM) regarding the total number of animals spoken, number of categories, groups and category switches on the VF test. Methods: We used the database of the FIBRA (Frailty in Brazilian Elderly) community-based study...
October 2017: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29354220/hypertension-diabetes-and-obesity-are-associated-with-lower-cognitive-performance-in-community-dwelling-elderly-data-from-the-fibra-study
#19
Monalisa Fernanda Bocchi de Oliveira, Mônica Sanches Yassuda, Ivan Aprahamian, Anita Liberalesso Neri, Maria Elena Guariento
Background: Systemic hypertension (SH), diabetes mellitus (DM) and abdominal obesity may negatively impact cognitive performance. Objective: To evaluate the association between SH, DM and abdominal obesity and cognitive performance among cognitively unimpaired elderly. Methods: A cross-sectional study of individuals aged 65+ from seven Brazilian cities was conducted. SH and DM diagnoses were self-reported and abdominal circumference was objectively measured...
October 2017: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29354216/mixed-dementia-a-review-of-the-evidence
#20
Nilton Custodio, Rosa Montesinos, David Lira, Eder Herrera-Pérez, Yadira Bardales, Lucía Valeriano-Lorenzo
Mixed dementia is the coexistence of Alzheimer's disease and cerebrovascular disease (CVD) in the same demented patient. Currently, its diagnosis and treatment remains a challenge for practitioners. To provide an overview of the epidemiology, pathogenesis, natural history, diagnosis, and therapy of Mixed Vascular-Alzheimer Dementia (MVAD). The literature was reviewed for articles published between 1990-2016 by using the keywords linked to MVAD. Neuropathological studies indicate that MVAD is a very common pathological finding in the elderly with a prevalence about of 22%...
October 2017: Dementia & Neuropsychologia
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