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https://www.readbyqxmd.com/read/27904882/first-case-of-actinomycetoma-in-france-due-to-a-novel-nocardia-species-nocardia-boironii-sp-nov
#1
Jacques M Gilquin, Brigitte Riviere, Valme Jurado, Bernard Audouy, Jean-Baptiste Kouatche, Emmanuelle Bergeron, Delphine Mouniée, Thierry Molina, Philippe Faure, Cesáreo Saiz-Jimenez, Verónica Rodríguez-Nava
Bacterial mycetoma is a neglected disease mainly observed in tropical area countries and typically associated with rural conditions, making its presence in developed countries of temperate climate areas rare. However, we report the first case of an autochthonous mycetoma case in continental France that originated from a new Nocardia species. A Gram-positive filamentous bacterium (OFN 14.177(T)) was isolated from a pus sample from the mycetoma of a male French patient 92 years old suffering from chronic lymphocytic leukemia...
November 2016: MSphere
https://www.readbyqxmd.com/read/27580930/predictors-of-morbidity-and-cleavage-plane-in-surgical-resection-of-pure-convexity-meningiomas-using-cerebrospinal-fluid-sensitive-image-subtraction-magnetic-resonance-imaging
#2
José Luis Thenier-Villa, Raúl Alejandro Galárraga Campoverde, Adolfo Ramón DE LA Lama Zaragoza, Cesáreo Conde Alonso
Meningiomas are the most common primary intracranial tumors. Since the adhesions in the plane of dissection are of interest in surgical planning, we suggest that digital image subtraction of FLAIR data from the T2 sequence of MRI may represent better the CSF spaces in the brain-tumor interface and may be a predictor of the intraoperative cleavage plane. From 2006 to 2016, 83 convexity meningiomas were resected in the Department of Neurosurgery of the University Hospital Complex of Vigo, an analysis of preoperative MRI was performed to assess peritumoral edema (PTE), tumor volume, among others; a digital subtraction of T2-FLAIR sequences was performed and analyzed in relationship to the cleavage plane described in the intraoperative report and postoperative neurological deficits...
August 31, 2016: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/27487560/correction-to-tetrahydroisoquinoline-derived-urea-and-2-5-diketopiperazine-derivatives-as-selective-antagonists-of-the-transient-receptor-potential-melastatin-8-trpm8-channel-receptor-and-antiprostate-cancer-agents
#3
Luciano De Petrocellis, Francisco J Arroyo, Pierangelo Orlando, Aniello Schiano Moriello, Rosa Maria Vitale, Pietro Amodeo, Aránzazu Sánchez, Cesáreo Roncero, Giulia Bianchini, M Antonia Martín, Pilar López-Alvarado, J Carlos Menéndez
No abstract text is available yet for this article.
August 25, 2016: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27452992/analytical-pyrolysis-and-stable-isotope-analyses-reveal-past-environmental-changes-in-coralloid-speleothems-from-easter-island-chile
#4
Ana Z Miller, José M De la Rosa, Nicasio T Jiménez-Morillo, Manuel F C Pereira, José A González-Pérez, José M Calaforra, Cesareo Saiz-Jimenez
This study comprises an innovative approach based on the combination of chromatography (analytical pyrolysis and pyrolysis compound-specific isotope analysis (Py-CSIA)), light stable isotopes, microscopy and mineralogy analyses to characterize the internal layering of coralloid speleothems from the Ana Heva lava tube in Easter Island (Chile). This multidisciplinary proxy showed that the speleothems consist of banded siliceous materials of low crystallinity with different mineralogical compositions and a significant contribution of organic carbon...
August 26, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/27232526/tetrahydroisoquinoline-derived-urea-and-2-5-diketopiperazine-derivatives-as-selective-antagonists-of-the-transient-receptor-potential-melastatin-8-trpm8-channel-receptor-and-antiprostate-cancer-agents
#5
Luciano De Petrocellis, Francisco J Arroyo, Pierangelo Orlando, Aniello Schiano Moriello, Rosa Maria Vitale, Pietro Amodeo, Aránzazu Sánchez, Cesáreo Roncero, Giulia Bianchini, M Antonia Martín, Pilar López-Alvarado, J Carlos Menéndez
Tetrahydroisoquinoline derivatives containing embedded urea functions were identified as selective TRPM8 channel receptor antagonists. Structure-activity relationships were investigated, with the following conclusions: (a) The urea function and the tetrahydroisoquinoline system are necessary for activity. (b) Bis(1-aryl-6,7dimethoxy-1,2,3,4-tetrahydroisoquinolyl)ureas are more active than compounds containing one tetrahydroisoquinoline ring and than an open phenetylamine ureide. (c) Trans compounds are more active than their cis isomers...
June 23, 2016: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27175804/effects-of-a-multidisciplinary-body-weight-reduction-program-on-static-and-dynamic-thoraco-abdominal-volumes-in-obese-adolescents
#6
Antonella LoMauro, Ambra Cesareo, Fiorenza Agosti, Gabriella Tringali, Desy Salvadego, Bruno Grassi, Alessandro Sartorio, Andrea Aliverti
The objective of this study was to characterize static and dynamic thoraco-abdominal volumes in obese adolescents and to test the effects of a 3-week multidisciplinary body weight reduction program (MBWRP), entailing an energy-restricted diet, psychological and nutritional counseling, aerobic physical activity, and respiratory muscle endurance training (RMET), on these parameters. Total chest wall (VCW), pulmonary rib cage (VRC,p), abdominal rib cage (VRC,a), and abdominal (VAB) volumes were measured on 11 male adolescents (Tanner stage: 3-5; BMI standard deviation score: >2; age: 15...
June 2016: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/27133764/-hyperbilirubinemia-asymptomatic-as-presentation-of-autoimmune-hepatitis-in-an-elderly-patient
#7
Agustín Querejeta, Ana Isabel Hormigo-Sánchez, Cesáreo Fernández-Alonso, Francisco Javier Martín-Sánchez
No abstract text is available yet for this article.
April 28, 2016: Revista Española de Geriatría y Gerontología
https://www.readbyqxmd.com/read/27111567/disparities-in-health-care-in-puerto-rico-compared-with-the-united-states
#8
Héctor M Colón, Marizaida Sánchez-Cesareo
No abstract text is available yet for this article.
June 1, 2016: JAMA Internal Medicine
https://www.readbyqxmd.com/read/26971128/paracoccus-cavernae-sp-nov-isolated-from-a-show-cave
#9
Irene Dominguez-Moñino, Valme Jurado, Bernardo Hermosin, Cesareo Saiz-Jimenez
A Gram-stain-negative, aerobic, non-motile, non-spore-forming bacterium, strain 0511ARD5E5T, was isolated from an air sample collected in Ardales Cave (Malaga, Spain). Strain 0511ARD5E5T grew at 4-37 °C and in the presence of 0-4 % (w/v) NaCl [optimally at 25 °C and with 1 % (w/v) NaCl]. Cells were catalase- and oxidase-positive. The major respiratory quinone was ubiquinone-10. The predominant fatty acids were C18:1ω7c and C16:0. The DNA G+C content was 63.2 mol%. Phylogenetic analysis based on 16S rRNA gene sequences showed that strain 0511ARD5E5T was a member of the genus Paracoccus and was related most closely to Paracoccus aminophilus DSM 8538T and Paracoccus marinus CIP 108500T (96...
June 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/26969462/italian-association-of-clinical-endocrinologists-ame-position-statement-drug-therapy-of-osteoporosis
#10
F Vescini, R Attanasio, A Balestrieri, F Bandeira, S Bonadonna, V Camozzi, S Cassibba, R Cesareo, I Chiodini, C Maria Francucci, L Gianotti, F Grimaldi, R Guglielmi, B Madeo, C Marcocci, A Palermo, A Scillitani, E Vignali, V Rochira, M Zini
Treatment of osteoporosis is aimed to prevent fragility fractures and to stabilize or increase bone mineral density. Several drugs with different efficacy and safety profiles are available. The long-term therapeutic strategy should be planned, and the initial treatment should be selected according to the individual site-specific fracture risk and the need to give the maximal protection when the fracture risk is highest (i.e. in the late life). The present consensus focused on the strategies for the treatment of postmenopausal osteoporosis taking into consideration all the drugs available for this purpose...
July 2016: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/26940993/rsk3-is-required-for-concentric-myocyte-hypertrophy-in-an-activated-raf1-model-for-noonan-syndrome
#11
Catherine L Passariello, Eliana C Martinez, Hrishikesh Thakur, Maria Cesareo, Jinliang Li, Michael S Kapiloff
Noonan syndrome (NS) is a congenital disorder resulting from mutations of the Ras-Raf signaling pathway. Hypertrophic cardiomyopathy associated with RAF1 "RASopathy" mutations is a major risk factor for heart failure and death in NS and has been attributed to activation of MEK1/2-ERK1/2 mitogen-activated protein kinases. We recently discovered that type 3 p90 ribosomal S6 kinase (RSK3) is an ERK effector that is required, like ERK1/2, for concentric myocyte hypertrophy in response to pathological stress such as pressure overload...
April 2016: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/26916908/-clinical-profile-and-90-day-mortality-in-centenarian-patients-attended-in-emergency-departments
#12
Francisco Javier Martín-Sánchez, Cesáreo Fernández-Alonso, Ana Isabel Hormigo, Gregorio Jiménez-Díaz, Honan Roiz, Cristina Bermejo-Boixareu, Jaime Rodríguez-Salazar, Cristina Fernández Pérez, Pedro Gil-Gregorio
OBJECTIVES: To determine the clinical profile and to develop a model to predict 90-day mortality in centenarian patients attended in emergency departments (ED). METHODOLOGY: This was an observational, retrospective, multicentre cohort study including patients >99years attended in 5 ED in the Community of Madrid from January to December 2012. Demographic variables were recorded, as well as, comorbidities, cognitive, functional, social basal status, geriatric syndromes, acute episode, and hospital and social resources use, and 90-day mortality...
July 2016: Revista Española de Geriatría y Gerontología
https://www.readbyqxmd.com/read/26733792/association-between-alzheimer-s-disease-and-glaucoma-a-study-based-on-heidelberg-retinal-tomography-and-frequency-doubling-technology-perimetry
#13
Massimo Cesareo, Alessio Martucci, Elena Ciuffoletti, Raffaele Mancino, Angelica Cerulli, Roberto P Sorge, Alessandro Martorana, Giuseppe Sancesario, Carlo Nucci
AIM: To assess the frequency of glaucoma-like alterations in Alzheimer's disease (AD) patients using Heidelberg Retinal Tomograph III (HRT-3) and Frequency Doubling Technology (FDT) perimetry. METHODS: The study included 51 eyes of 51 AD subjects and 67 eyes of 67 age- and sex-matched controls. Subjects underwent an ophthalmological examination including measurements of intraocular pressure (IOP), Matrix FDT visual field testing, optic nerve head morphology and retinal nerve fiber layer thickness (RNFLt) assessment by slit-lamp biomicroscopy and HRT-3...
2015: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/26696966/actinobacterial-diversity-in-volcanic-caves-and-associated-geomicrobiological-interactions
#14
Cristina Riquelme, Jennifer J Marshall Hathaway, Maria de L N Enes Dapkevicius, Ana Z Miller, Ara Kooser, Diana E Northup, Valme Jurado, Octavio Fernandez, Cesareo Saiz-Jimenez, Naowarat Cheeptham
Volcanic caves are filled with colorful microbial mats on the walls and ceilings. These volcanic caves are found worldwide, and studies are finding vast bacteria diversity within these caves. One group of bacteria that can be abundant in volcanic caves, as well as other caves, is Actinobacteria. As Actinobacteria are valued for their ability to produce a variety of secondary metabolites, rare and novel Actinobacteria are being sought in underexplored environments. The abundance of novel Actinobacteria in volcanic caves makes this environment an excellent location to study these bacteria...
2015: Frontiers in Microbiology
https://www.readbyqxmd.com/read/26518087/visual-disability-and-quality-of-life-in-glaucoma-patients
#15
Massimo Cesareo, Elena Ciuffoletti, Federico Ricci, Filippo Missiroli, Mario Alberto Giuliano, Raffaele Mancino, Carlo Nucci
Glaucoma is an optic neuropathy that can result in progressive and irreversible vision loss, thereby affecting quality of life (QoL) of patients. Several studies have shown a strong correlation between visual field damage and visual disability in patients with glaucoma, even in the early stages of the disease. Visual impairment due to glaucoma affects normal daily activities required for independent living, such as driving, walking, and reading. There is no generally accepted instrument for assessing quality of life in glaucoma patients; different factors involved in visual disability from the disease are difficult to quantify and not easily standardized...
2015: Progress in Brain Research
https://www.readbyqxmd.com/read/26518072/links-among-glaucoma-neurodegenerative-and-vascular-diseases-of-the-central-nervous-system
#16
Carlo Nucci, Alessio Martucci, Massimo Cesareo, Francesco Garaci, Luigi Antonio Morrone, Rossella Russo, Maria Tiziana Corasaniti, Giacinto Bagetta, Raffaele Mancino
Glaucoma is the leading cause of irreversible blindness worldwide. Although the intraocular pressure (IOP) has been considered for long time the key point and the only treatable risk factor of the disease, there are cases in which glaucoma continues to progress despite normal IOP values. Vision loss in glaucoma is related to a selective decrease in the number of retinal ganglion cells by apoptosis that is associated to alterations of the central visual pathways. Interestingly, similar events have been also described in disorders of the central nervous system (CNS), such as Alzheimer's disease, Parkinson's disease, Leber's hereditary optic neuropathy, and cerebrovascular diseases...
2015: Progress in Brain Research
https://www.readbyqxmd.com/read/26493333/a-prospective-nonrandomized-study-on-carotid-surgery-performed-under-general-anesthesia-without-intraoperative-cerebral-monitoring
#17
Francesco De Santis, Cristina Margot Chaves Brait, Cristian Pattaro, Vladimiro Cesareo, Vincenzo Di Cintio
BACKGROUND: The purpose of this study was to assess our experience of carotid surgery habitually performed under general anesthesia without intraoperative intracerebral monitoring, and following a pre-established perioperative protocol, which includes extensive use of an intraoperative shunt (IOS). METHODS: This study included 311 consecutive carotid operations performed over 32 months. This patient cohort represents 14% of our total experience in carotid surgery (2219 operations, major stroke/mortality rate: 1...
January 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/26343646/bmp9-induced-survival-effect-in-liver-tumor-cells-requires-p38mapk-activation
#18
María García-Álvaro, Annalisa Addante, Cesáreo Roncero, Margarita Fernández, Isabel Fabregat, Aránzazu Sánchez, Blanca Herrera
The study of bone morphogenetic proteins (BMPs) role in tumorigenic processes, and specifically in the liver, has gathered importance in the last few years. Previous studies have shown that BMP9 is overexpressed in about 40% of hepatocellular carcinoma (HCC) patients. In vitro data have also shown evidence that BMP9 has a pro-tumorigenic action, not only by inducing epithelial to mesenchymal transition (EMT) and migration, but also by promoting proliferation and survival in liver cancer cells. However, the precise mechanisms driving these effects have not yet been established...
August 28, 2015: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/26237771/optic-nerve-dysfunction-in-obstructive-sleep-apnea-an-electrophysiological-study
#19
Claudio Liguori, Maria Giuseppina Palmieri, Mariangela Pierantozzi, Massimo Cesareo, Andrea Romigi, Francesca Izzi, Maria Grazia Marciani, Corrado Oliva, Nicola Biagio Mercuri, Fabio Placidi
STUDY OBJECTIVES: The aim of this study was to evaluate the integrity of the visual system in patients affected by obstructive sleep apnea (OSA) by means of electroretinogram (ERG) and visual evoked potential (VEP). METHODS: We performed electrophysiological study of the visual system in a population of severe OSA (apnea-hypopnea events/time in bed ≥ 30/h) patients without medical comorbidities compared to a group of healthy controls similar for age, sex, and body mass index...
January 1, 2016: Sleep
https://www.readbyqxmd.com/read/26205648/effectiveness-and-safety-of-calcium-and-vitamin-d-treatment-for-postmenopausal-osteoporosis
#20
REVIEW
R Cesareo, M Iozzino, L D'onofrio, I Terrinoni, E Maddaloni, A Casini, G Campagna, A Santonati, A Palermo
Imbalance of bone resorption and bone formation is responsible for osteoporosis that is characterized by decreased bone mass and mineral density. The aim of this study was to evaluate the available data that could clarify the effectiveness and safety of supplementations with calcium and vitamin D, alone or in combination, to slow down bone loss in postmenopausal and elderly women. Using search key words, we performed a research both in the PubMed and Cochrane Library in order to find all meta-analysis, prospective and randomized clinical studies published from 2000 to 2014 that had investigated the effectiveness of calcium and vitamin D in the treatment of osteoporosis...
September 2015: Minerva Endocrinologica
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