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https://www.readbyqxmd.com/read/29751359/bone-morphogenetic-protein-9-as-a-key-regulator-of-liver-progenitor-cells-in-ddc-induced-cholestatic-liver-injury
#1
Annalisa Addante, Cesáreo Roncero, Laura Almalé, Nerea Lazcanoiturburu, María García-Álvaro, Margarita Fernández, Julián Sanz, Seddik Hammad, Zeribe Chike Nwosu, Se-Jin Lee, Isabel Fabregat, Steven Dooley, Peter Ten Dijke, Blanca Herrera, Aránzazu Sánchez
BACKGROUND & AIMS: Bone morphogenetic protein 9 (BMP9) interferes with liver regeneration upon acute injury, while promoting fibrosis upon carbon tetrachloride-induced chronic injury. We have now addressed the role of BMP9 in 3,5 diethoxicarbonyl-1,4 dihydrocollidine (DDC)-induced cholestatic liver injury, a model of liver regeneration mediated by hepatic progenitor cell (known as oval cell), exemplified as ductular reaction and oval cell expansion. METHODS: WT and BMP9KO mice were submitted to DDC diet...
May 11, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29732047/rehabilitation-of-upper-limb-in-children-with-acquired-brain-injury-a-preliminary-comparative-study
#2
Elena Beretta, Ambra Cesareo, Emilia Biffi, Carolyn Schafer, Sara Galbiati, Sandra Strazzer
Acquired brain injuries (ABIs) can lead to a wide range of impairments, including weakness or paralysis on one side of the body known as hemiplegia. In hemiplegic patients, the rehabilitation of the upper limb skills is crucial, because the recovery has an immediate impact on patient quality of life. For this reason, several treatments were developed to flank physical therapy (PT) and improve functional recovery of the upper limbs. Among them, Constraint-Induced Movement Therapy (CIMT) and robot-aided therapy have shown interesting potentialities in the rehabilitation of the hemiplegic upper limb...
2018: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29704186/immersive-virtual-reality-to-improve-walking-abilities-in-cerebral-palsy-a-pilot-study
#3
Chiara Gagliardi, Anna Carla Turconi, Emilia Biffi, Cristina Maghini, Alessia Marelli, Ambra Cesareo, Eleonora Diella, Daniele Panzeri
Immersive virtual reality (IVR) offers new possibilities to perform treatments in an ecological and interactive environment with multimodal online feedbacks. Sixteen school-aged children (mean age 11 ± 2.4 years) with Bilateral CP-diplegia, attending mainstream schools were recruited for a pilot study in a pre-post treatment experimental design. The intervention was focused on walking competences and endurance and performed by the Gait Real-time Analysis Interactive Lab (GRAIL), an innovative treadmill platform based on IVR...
April 27, 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29702603/italian-association-of-clinical-endocrinologists-ame-and-italian-chapter-of-the-american-association-of-clinical-endocrinologists-aace-position-statement-clinical-management-of-vitamin-d-deficiency-in-adults
#4
Roberto Cesareo, Roberto Attanasio, Marco Caputo, Roberto Castello, Iacopo Chiodini, Alberto Falchetti, Rinaldo Guglielmi, Enrico Papini, Assunta Santonati, Alfredo Scillitani, Vincenzo Toscano, Vincenzo Triggiani, Fabio Vescini, Michele Zini
Vitamin D deficiency is very common and prescriptions of both assay and supplementation are increasing more and more. Health expenditure is exponentially increasing, thus it is timely and appropriate to establish rules. The Italian Association of Clinical Endocrinologists appointed a task force to review literature about vitamin D deficiency in adults. Four topics were identified as worthy for the practicing clinicians. For each topic recommendations based on scientific evidence and clinical practice were issued according to the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) System...
April 27, 2018: Nutrients
https://www.readbyqxmd.com/read/29559211/tracheotomy-in-the-intensive-care-unit-guidelines-from-a-french-expert-panel-the-french-intensive-care-society-and-the-french-society-of-anaesthesia-and-intensive-care-medicine
#5
Jean-Louis Trouillet, Olivier Collange, Fouad Belafia, François Blot, Gilles Capellier, Eric Cesareo, Jean-Michel Constantin, Alexandre Demoule, Jean-Luc Diehl, Pierre-Grégoire Guinot, Franck Jegoux, Erwan L'Her, Charles-Edouard Luyt, Yazine Mahjoub, Julien Mayaux, Hervé Quintard, François Ravat, Sébastien Vergez, Julien Amour, Max Guillot
Tracheotomy is widely used in intensive care units, albeit with great disparities between medical teams in terms of frequency and modality. Indications and techniques are, however, associated with variable levels of evidence based on inhomogeneous or even contradictory literature. Our aim was to conduct a systematic analysis of the published data in order to provide guidelines. We present herein recommendations for the use of tracheotomy in adult critically ill patients developed using the grading of recommendations assessment, development and evaluation (GRADE) method...
March 17, 2018: Anaesthesia, Critical Care & Pain Medicine
https://www.readbyqxmd.com/read/29546588/tracheotomy-in-the-intensive-care-unit-guidelines-from-a-french-expert-panel
#6
REVIEW
Jean Louis Trouillet, Olivier Collange, Fouad Belafia, François Blot, Gilles Capellier, Eric Cesareo, Jean-Michel Constantin, Alexandre Demoule, Jean-Luc Diehl, Pierre-Grégoire Guinot, Franck Jegoux, Erwan L'Her, Charles-Edouard Luyt, Yazine Mahjoub, Julien Mayaux, Hervé Quintard, François Ravat, Sebastien Vergez, Julien Amour, Max Guillot
Tracheotomy is widely used in intensive care units, albeit with great disparities between medical teams in terms of frequency and modality. Indications and techniques are, however, associated with variable levels of evidence based on inhomogeneous or even contradictory literature. Our aim was to conduct a systematic analysis of the published data in order to provide guidelines. We present herein recommendations for the use of tracheotomy in adult critically ill patients developed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) method...
March 15, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29521197/neurodegenerative-process-linking-the-eye-and-the-brain
#7
Raffaele Mancino, Massimo Cesareo, Alessio Martucci, Emiliano Di Carlo, Elena Ciuffoletti, Clarissa Giannini, Luigi Antonio Morrone, Carlo Nucci, Francesco Garaci
Recent literature agrees that neurodegenerative processes involve both the retina and the central nervous system, which are two strictly related anatomical structures. However, the causal mechanisms of this dual involvement are still uncertain. To date, anterograde transynaptic neurodegeneration, triggered by retinal ganglion cells' death, and retrograde transynaptic neurodegeneration, induced by neurodegenerative processes of the central nervous system, have been considered the major possible causal mechanisms...
March 6, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29395538/bacillus-onubensis-sp-nov-isolated-from-the-air-of-two-andalusian-caves
#8
Irene Dominguez-Moñino, Valme Jurado, Jose L Gonzalez-Pimentel, Ana Zelia Miller, Bernardo Hermosin, Cesareo Saiz-Jimenez
Two Gram-positive, catalase-positive, oxidase-negative, motile, endospore-forming, rod-shaped bacteria, designated as 0911MAR22V3T and 0911TES10J4, were isolated from air samples collected in two show caves, located in Andalusia, Southern Spain. Phylogenetic analysis based on 16S rRNA gene sequences indicated that both strains were indistinguishable and they were most closely related to Bacillus humi DSM 16318T (98%). DNA-DNA hybridization values of the strain 0911MAR22V3T with respect to strain 0911TES10J4 and B...
May 2018: Systematic and Applied Microbiology
https://www.readbyqxmd.com/read/29386569/yellow-coloured-mats-from-lava-tubes-of-la-palma-canary-islands-spain-are-dominated-by-metabolically-active-actinobacteria
#9
Jose L Gonzalez-Pimentel, Ana Z Miller, Valme Jurado, Leonila Laiz, Manuel F C Pereira, Cesareo Saiz-Jimenez
Microbial diversity in lava tubes from Canary Islands (Spain) has never been explored thus far offering a unique opportunity to study subsurface microbiology. Abundant yellow coloured mats developing on coralloid speleothems in a lava tube from La Palma Islands were studied by next-generation sequencing and DNA/RNA clone library analyses for investigating both total and metabolically active bacteria. In addition, morphological and mineralogical characterization was performed by field emission scanning electron microscopy (FESEM), micro-computed tomography, X-ray diffraction and infrared spectroscopy to contextualize sequence data...
January 31, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29357717/nodule-size-as-predictive-factor-of-efficacy-of-radiofrequency-ablation-in-treating-autonomously-functioning-thyroid-nodules
#10
R Cesareo, A M Naciu, M Iozzino, V Pasqualini, C Simeoni, A Casini, G Campagna, S Manfrini, G Tabacco, A Palermo
CONTEXT: No defined pre-treatment factors are able to predict the response to radiofrequency ablation (RFA) of an autonomously functioning thyroid nodule (AFTN). OBJECTIVE: Primary endpoint was to evaluate the success rate of RFA to restore euthyroidism in a cohort of adult patients with small solitary AFTN compared with medium-sized nodules. Secondary endpoints included nodule volume reduction and rate of conversion from hot nodules to cold using scintiscan. METHODS: This was a 24-month prospective monocentric open parallel-group trial...
February 6, 2018: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29227640/raman-spectroscopy-applied-to-parathyroid-tissues-a-new-diagnostic-tool-to-discriminate-normal-tissue-from-adenoma
#11
Andrea Palermo, Marco Fosca, Gaia Tabacco, Federico Marini, Valerio Graziani, Maria Carla Santarsia, Filippo Longo, Angelo Lauria, Roberto Cesareo, Isabella Giovannoni, Chiara Taffon, Massimiliano Rocchia, Silvia Manfrini, Pierfilippo Crucitti, Paolo Pozzilli, Anna Crescenzi, Julietta V Rau
Primary hyperparathyroidism is an endocrine disorder characterized by autonomous production of parathyroid hormone. Patients with the symptomatic disease should be referred for parathyroidectomy. However, the distinction between the pathological condition and the benign one is very challenging in the surgical setting; therefore, accurate recognition is important to ensure success during minimally invasive surgery. At present, all intraoperative techniques significantly increase surgical time and, consequently, cost...
January 2, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29221551/-reflections-on-prehospitalisation-deaths
#12
REVIEW
Delphine Hugenschmitt, Alexandre Allonneau, Éric Cesareo, Pierre-Yves Gueugniaud, Hugues Lefort
In the past, death was a family and community affair, but today it is institutional and entrusted to healthcare personnel. Thanks to a questionnaire on their feelings about prehospitalisation deaths, the experience and training needs for healthcare personnel at a mobile emergency and intensive care service were analysed. The majority of these professionals had been confronted with difficulties when faced with prehospitalisation deaths. There is little understanding of religious rites, even though this is an important point in dealing with the situation...
December 2017: Soins; la Revue de Référence Infirmière
https://www.readbyqxmd.com/read/29210654/glaucoma-and-alzheimer-disease-a-single-age-related-neurodegenerative-disease-of-the-brain
#13
Raffaele Mancino, Alessio Martucci, Massimo Cesareo, Clarissa Giannini, Maria Tiziana Corasaniti, Giacinto Bagetta, Carlo Nucci
Open Angle Glaucoma is one of the leading causes of irreversible blindness worldwide. Elevated intraocular pressure is considered an important risk factor for glaucoma, however a subset of patients experience disease progression even in presence of normal intraocular pressure values. This implies that risk factors other than intraocular pressure are involved in the pathogenesis of glaucoma. A possible relationship between glaucoma and neurodegenerative diseases such as Alzheimer Disease has been suggested. In this regard, we have recently described a high prevalence of alterations typical of glaucoma, using Heidelberg Retinal Tomograph-3 (HRT-3), in a group of patients with Alzheimer Disease...
December 6, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/29160051/irisin-as-a-regulator-of-bone-and-glucose-metabolism-a-narrative-review
#14
Silvia I Briganti, Gianluigi Gaspa, Gaia Tabacco, Anda M Naciu, Roberto Cesareo, Silvia Manfrini, Andrea Palermo
In humans, irisin is produced mainly by skeletal muscle in response to physical activity. It has been demonstrated that irisin plays a pivotal role in inducing fat browning and regulating energy expenditure. New findings from various studies conducted in both animals and humans suggest that irisin can affect bone and glucose metabolism. In particular, irisin is able to increase bone cortical mass by stimulating the osteoblast pathways, and irisin levels are inversely correlated with the incidence of fragility fractures among postmenopausal women affected by osteoporosis...
November 20, 2017: Minerva Endocrinologica
https://www.readbyqxmd.com/read/29077327/pulse-co-oximetry-in-prehospital-care
#15
EDITORIAL
Cesáreo Álvarez Rodríguez, Manuel José Vázquez Lima
No abstract text is available yet for this article.
February 2017: Emergencias: Revista de la Sociedad Española de Medicina de Emergencias
https://www.readbyqxmd.com/read/29060382/a-novel-low-cost-wearable-contact-based-device-for-breathing-frequency-monitoring
#16
Ambra Cesareo, Stefano Gandolfi, Ilaria Pini, Emilia Biffi, Gianluigi Reni, Andrea Aliverti
This paper presents a device for breathing frequency assessment over the long period, based on low cost, wearable inertial units. Performances of the device were evaluated in static conditions on 9 healthy subjects and the estimated parameters were compared to those obtained with an already validated method (Optoelectronic Plethysmography). We obtained good correlation values (R2 > 0.88) and low percentage errors (<;5%) for all the time-based parameters extracted.
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29060103/a-tapping-device-for-recording-and-quantitative-characterization-of-rhythmic-auditory-sequences
#17
Caterina Piazza, Ambra Cesareo, Martina Caccia, Gianluigi Reni, Maria L Lorusso
The processing of auditory stimuli is essential for the correct perception of language and deficits in this ability are often related to the presence or development of language disorders. The motor imitation (e.g. tapping or beating) of rhythmic sequences can be a very sensitive correlate of deficits in auditory processing. Thus, the study of the tapping performance, with the investigation of both temporal and intensity information, might be very useful. The present work is aimed at the development and preliminary testing of a tapping device to be used for the imitation and/or the production of rhythmic sequences, allowing the recording of both tapping duration and intensity...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29044220/structure-of-melanins-from-the-fungi-ochroconis-lascauxensis-and-ochroconis-anomala-contaminating-rock-art-in-the-lascaux-cave
#18
José Maria De la Rosa, Pedro M Martin-Sanchez, Santiago Sanchez-Cortes, Bernardo Hermosin, Heike Knicker, Cesareo Saiz-Jimenez
Two novel species of the fungal genus Ochroconis, O. lascauxensis and O. anomala have been isolated from the walls of the Lascaux Cave, France. The interest in these fungi and their melanins lies in the formation of black stains on the walls and rock art which threatens the integrity of the paintings. Here we report solid-state cross polarization magic-angle spinning13 C and15 N nuclear magnetic resonance (NMR) spectroscopy and surface-enhanced Raman spectroscopy (SERS) of the melanins extracted from the mycelia of O...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29033263/-persistent-extra-axial-post-surgical-collections-and-propionibacterium-acnes-infection-presentation-of-two-cases-and-literature-review
#19
Pedro González, José Thenier, Raúl Galárraga, Adolfo de la Lama, Eva Azevedo, Cesáreo Conde
OBJECTIVES: It is common to observe the persistence of extra-axial collections after craniotomies. Most of these disappear in weeks or months but some remain. The onset of focal symptoms or the growth of these persistent collections months or years after surgery may indicate the presence of a chronic and latent infection by germs of low virulence such as Propionibacterium acnes (P. acnes). METHODS: We present two clinical cases with persistent extra-axial collections, which required surgery years after diagnosis, in which P...
October 13, 2017: Neurocirugía
https://www.readbyqxmd.com/read/29026341/benefits-of-different-postoperative-treatments-in-patients-undergoing-knee-arthroscopic-debridement
#20
Cesáreo Trueba Vasavilbaso, Carlos David Rosas Bello, Erla Medina López, Maria Pilar Coronel Granado, José Mario Navarrete Álvarez, Cesáreo Angel Trueba Davalillo, Félix Isaac Gil Orbezo
PURPOSE: To assess the effectiveness of viscosupplementation or platelet-rich plasma (PRP), compared to standard care, for pain relief after knee arthroscopic debridement in patients with meniscal pathology and osteoarthritis (OA), under normal clinical practice conditions. PATIENTS AND METHODS: We conducted a prospective, randomized, evaluator-blind, pilot study. After arthroscopy, patients were randomized to receive 1) five injections of HA1 (Suprahyal® /Adant® ); 2) four injections of HA2 (Orthovisc® ); 3) three injections of HA3 (Synvisc® ); 4) a single injection of PRP (GPS™ II); or 5) standard care (control)...
2017: Open Access Rheumatology: Research and Reviews
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