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Amoxicillin/clavulanic acid

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https://www.readbyqxmd.com/read/29149094/genomic-analysis-of-third-generation-cephalosporin-resistant-escherichia-coli-from-dairy-cow-manure
#1
Muhammad Attiq Rehman, Xianhua Yin, Dion Lepp, Chad Laing, Kim Ziebell, Guylaine Talbot, Edward Topp, Moussa Sory Diarra
The production of extended-spectrum β-lactamases (ESBLs) conferring resistance to new derivatives of β-lactams is a major public health threat if present in pathogenic Gram-negative bacteria. The objective of this study was to characterize ceftiofur (TIO)- or cefotaxime (FOX)-resistant Escherichia coli isolated from dairy cow manure. Twenty-four manure samples were collected from four farms and incubated under anaerobic conditions for 20 weeks at 4 °C or at 25 °C. A total of 37 TIO- or FOX-resistant E. coli were isolated from two of the four farms to determine their susceptibility to 14 antibiotics...
November 17, 2017: Veterinary Sciences
https://www.readbyqxmd.com/read/29147114/antibiotic-resistant-bacterial-isolates-from-captive-green-turtles-and-in-vitro-sensitivity-to-bacteriophages
#2
Alessandro Delli Paoli Carini, Ellen Ariel, Jacqueline Picard, Lisa Elliott
This study aimed to test multidrug resistant isolates from hospitalised green turtles (Chelonia mydas) and their environment in North Queensland, Australia, for in vitro susceptibility to bacteriophages. Seventy-one Gram-negative bacteria were isolated from green turtle eye swabs and water samples. Broth microdilution tests were used to determine antibiotic susceptibility. All isolates were resistant to at least two antibiotics, with 24% being resistant to seven of the eight antibiotics. Highest resistance rates were detected to enrofloxacin (77%) and ampicillin (69...
2017: International Journal of Microbiology
https://www.readbyqxmd.com/read/29139370/perianal-ulcer-in-an-asian-man
#3
Nilanthy Sharon Anthony Pillai, Choon Chiat Oh, Michelle Chan Mei Fung, Limin Wijaya
A 79-year-old Chinese man presented with a 2-month history of pruritic, tender ulceration covering his perianal region. He was initially treated with oral amoxicillin/clavulanic acid and vancyclovir, with no improvement. His history included hypertension. On physical examination, there was a 1.5-cm solitary, pink shallow ulcer with a tender erythematous base on the right side of the buttock cleft (Figure 1).
2017: Skinmed
https://www.readbyqxmd.com/read/29136160/highly-variable-absorption-of-clavulanic-acid-during-the-day-a-population-pharmacokinetic-analysis
#4
Femke De Velde, Brenda C M De Winter, Birgit C P Koch, Teun Van Gelder, Johan W Mouton
Objectives: To calculate the clavulanic acid exposure of oral amoxicillin/clavulanic acid dosing regimens, to investigate variability using a population pharmacokinetic model and to explore target attainment using Monte Carlo simulations. Methods: Two groups of healthy male volunteers received amoxicillin/clavulanic acid tablets at the start of a standard meal on two separate days 1 week apart. One group (n = 14) received 875/125 mg q12h and 500/125 mg q8h and the other group (n = 15) received 500/125 mg q12h and 250/125 mg q8h...
November 9, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29121183/primary-vs-secondary-endoscopic-dacryocystorhinostomy-for-acute-dacryocystitis-with-lacrimal-sac-abscess-formation-a-randomized-clinical-trial
#5
Emmy Y Li, Emily S Wong, Alex C Wong, Hunter K Yuen
Importance: Endoscopic dacryocystorhinostomy (EN-DCR) is emerging as the preferred procedure in the management of nasolacrimal duct obstructions. However, its safety and long-term efficacy in the setting of acute dacryocystitis with lacrimal sac abscess have not been well studied. Objective: To compare outcomes of EN-DCR as primary treatment with EN-DCR as a secondary treatment after percutaneous drainage of lacrimal sac abscess in acute dacryocystitis. Design, Setting, and Participants: This randomized clinical trial was conducted from October 1, 2012, to October 31, 2015, at a tertiary ophthalmic center...
November 9, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29109849/current-concepts-and-future-strategies-in-the-antimicrobial-therapy-of-emerging-gram-positive-spontaneous-bacterial-peritonitis
#6
REVIEW
Marco Fiore, Alberto Enrico Maraolo, Ivan Gentile, Guglielmo Borgia, Sebastiano Leone, Pasquale Sansone, Maria Beatrice Passavanti, Caterina Aurilio, Maria Caterina Pace
Spontaneous bacterial peritonitis (SBP) is the most common infection in end-stage liver disease patients. SBP is defined as an ascitic fluid infection with a polymorphonuclear leucocyte count ≥ 250/mm(3) without an evident intra-abdominal surgically treatable source. Several mechanisms contribute to SBP occurrence, including translocation of gut bacteria and their products, reduced intestinal motility provoking bacterial overgrowth, alteration of the gut's barrier function and local immune responses. Historically, Gram-negative enteric bacteria have been the main causative agents of SBP, thereby guiding the empirical therapeutic choice...
October 28, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/29107782/salmonella-including-antibiotic-resistant-salmonella-from-flies-captured-from-cattle-farms-in-georgia-u-s-a
#7
Yumin Xu, Sha Tao, Nancy Hinkle, Mark Harrison, Jinru Chen
Flies can be transmission vehicles of Salmonella from cattle to humans. This study determined the prevalence of Salmonella in/on flies captured from 33 cattle farms, including 5 beef and 28 dairy farms, in Georgia, USA, and characterized antibiotic resistance profiles of the isolated Salmonella. Twenty-six out of the 33 cattle farms (79%) and 185 out of the 1650 flies (11%) tested positive for Salmonella in the study. The incidence of Salmonella-positive flies varied from farm to farm, ranging from 0 to 78%...
November 3, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29077917/characterization-of-ornithobacterium-rhinotracheale-from-commercial-layer-chickens-in-eastern-japan
#8
D V Umali, K Shirota, K Sasai, H Katoh
From a total of 72 commercial layer and pullet farms that were monitored in the eastern Japan area, 4 farms had mild to severe respiratory disease accompanied by decreased feed intake and drop in egg production. Microbiological analysis showed that 3 of the 4 farms, particularly from Fukushima, Tochigi, and Ibaraki prefectures, were positive for Ornithobacterum rhinotracheale (ORT). Out of 65 birds examined, ORT was isolated in 21 birds (32.31%). All isolates were Gram-negative pleomorphic rods with a colony size of 0...
October 25, 2017: Poultry Science
https://www.readbyqxmd.com/read/29072245/impact-of-oral-antibiotics-on-health-related-quality-of-life-after-mandibular-third-molar-surgery-an-observational-study
#9
R O Braimah, K C Ndukwe, J F Owotade, S B Aregbesola
AIM: To compare the impact of antibiotics on health-related quality of life (QoL) outcomes following third molar surgery. MATERIALS AND METHODS: The study population consisted of 135 subjects that required surgical extraction of mandibular third molar under local anesthesia and met the inclusion criteria. The subjects were randomized into three study groups of 45 subjects each: Group A - extended amoxicillin/clavulanic acid (GlaxoSmithKline Beecham England), 1 gram pre-operatively and then 625 mg BD for 5 days Group B - prophylactic amoxicillin/clavulanic acid (GlaxoSmithKline Beecham England) 1 gram pre-operatively only, and Group C - prophylactic levofloxacin 1 gram pre-operatively only...
September 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29072041/epidemiology-of-serratia-marcescens-infections-in-nicu-of-a-teaching-and-research-hospital-in-northern-italy
#10
Elisa Buttinelli, Ilaria Ardoino, Giulia Domeniconi, Monica Lanzoni, Lorenza Pugni, Andrea Ronchi, Fabio Mosca, Elia Biganzoli, Silvana Castaldi
BACKGROUND: Serratia marcescens (Sm) is a known cause of infection and colonization in neonates receiving intensive care. The aim of this study was to identify the risk factors for colonization and infection with Sm in Neonatal Intensive Care Unit (NICU) of a tertiary care Hospital. METHODS: A casecontrol study was conducted from January to December 2011 in neonates admitted to the NICU. Cases are patients with a microbiologically confirmed infection or colonization, controls were randomly chosen among patients admitted to the same NICU...
October 25, 2017: Minerva Pediatrica
https://www.readbyqxmd.com/read/29052100/acute-localized-exanthematous-pustulosis-alep-review-of-literature-with-report-of-case-caused-by-amoxicillin-clavulanic-acid
#11
Alessia Villani, Antonello Baldo, Gaia De Fata Salvatores, Vincenzo Desiato, Fabio Ayala, Carlo Donadio
Acute localized exanthematous pustulosis (ALEP) is a localized form of acute generalized exanthematous pustulosis, characterized by acute onset of multiple nonfollicular, pinhead-sized, sterile pustules following drug administration. Antibiotics, especially β-lactams and macrolides, have been implicated in the majority of cases, although eruption after nonsteroidal antiinflammatory drugs and many other medications has also been reported. Skin reaction arises quickly within a few hours, resolving rapidly within a few days without treatment, and it is usually accompanied by fever and neutrophilic leukocytosis...
October 19, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/29042339/clonal-dissemination-of-oxa-48-producing-enterobacter-cloacae-isolated-from-companion-animals-in-algeria
#12
Massilia Yousfi, Abdelaziz Touati, Anaelle Muggeo, Brazane Mira, Asma Bourouis, Lucien Brasme, Thomas Guillard, Christophe de Champs
OBJECTIVES: The aim of this study was to investigate carbapenemase-producing Enterobacteriaceae (CPE) in companion animals. METHODS: Between October 2015 and April 2016, 533 rectal swabs were obtained from healthy and diseased pets in different cities in Algeria. Samples collected were plated on MacConkey agar supplemented with ertapenem (0.5mg/L). The isolates were identified by MALDI-TOF mass spectroscopy. Antimicrobial susceptibility testing was performed using disk diffusion method...
October 14, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29037164/local-epidemiology-and-resistance-profiles-in-acute-uncomplicated-cystitis-auc-in-women-a-prospective-cohort-study-in-an-urban-urological-ambulatory-setting
#13
Michael Seitz, Christian Stief, Raphaela Waidelich
BACKGROUND: Acute uncomplicated cystitis (AUC) is a common ailment in the urological setting. Guidelines for urinary tract infections are based on large-scale multi-centre, epidemiological and international studies. The objective of this observational study was to establish whether the results of a multi-centre study on the resistance profile of Escherichia coli (E. coli) in patients with AUC could be directly applied to an urological practice in a major European city or whether there are divergences in the resistance profile...
October 16, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29034106/epidemiology-and-antibiotic-resistance-phenotypes-of-diarrheagenic-escherichia-coli-responsible-for-infantile-gastroenteritis-in-ouagadougou-burkina-faso
#14
Ali Konaté, René Dembélé, Nathalie K Guessennd, Fernique Konan Kouadio, Innocent Kouamé Kouadio, Mohamed Baguy Ouattara, Wendpoulomdé A D Kaboré, Assèta Kagambèga, Haoua Cissé, Hadiza Bawa Ibrahim, Touwendsida Serge Bagré, Alfred S Traoré, Nicolas Barro
The emergence and persistence of multidrug-resistant (MDR) diarrheagenic Escherichia coli (DEC) causing acute diarrhea is a major public health challenge in developing countries. The aim of this study was to evaluate the resistance phenotypes of DEC isolated from stool samples collected from children less than 5 years of age with acute diarrhea living in Ouagadougou/Burkina Faso. From August 2013 to October 2015, this study was carried out on 31 DEC strains of our study conducted in "Centre Médical avec Antenne Chirurgicale (CMA)" Paul VI and CMA of Schiphra...
September 2017: European Journal of Microbiology & Immunology
https://www.readbyqxmd.com/read/29032522/comparative-characteristic-of-antimicrobial-resistance-in-geriatric-hospital-a-retrospective-cohort-study
#15
G Goltsman, E H Mizrahi, A Leibovitz, G Gal, O Gorelik, E Lubart
BACKGROUND AND AIMS: To examine antimicrobial resistance of commonly isolated pathogens in elderly hospitalized patients. METHODS: Data regarding all clinically significant isolates from blood and urine cultures of patients admitted to a multilevel geriatric hospital during March 2015 to April 2016 were collected. Antimicrobial susceptibility testing was performed according to Clinical and Laboratory Standard Institute guidelines. RESULTS: Escherichia coli, Proteus mirabilis, and Klebsiella pneumoniae were the most common isolates, with proportions of extended spectrum beta-lactamase positivity of 60, 40, and 61% respectively...
October 14, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29030135/staphylococcus-saprophyticus-which-beta-lactam
#16
Hélène Pailhoriès, Viviane Cassisa, Rachel Chenouard, Marie Kempf, Matthieu Eveillard, Carole Lemarié
BACKGROUND: Staphylococcus saprophyticus is resistant to the drugs most often used for the empirical treatment of urinary tract infections (UTI). The adequacy of antimicrobial treatments prescribed for UTI due to S. saprophyticus is not usually questioned. This study described the epidemiology of such infections and assessed the susceptibility of S. saprophyticus to ceftriaxone and amoxicillin-clavulanic acid. METHODS: Methicillin-susceptible S. saprophyticus (MSSS) isolated from clinical samples between November 2014 and July 2016 were included...
October 13, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29028568/virulence-genotypes-and-antimicrobial-susceptibility-patterns-of-arcobacter-butzleri-isolated-from-seafood-and-its-environment
#17
Srinu Rathlavath, Vandita Kohli, Asem Sanjit Singh, Manjusha Lekshmi, Gayatri Tripathi, Sanath Kumar, Binaya Bhusan Nayak
Arcobacter butzleri is an emerging pathogen isolated from animals, food and the environment. In this study, 147 A. butzleri isolated from seafood and the coastal environment were tested for the presence of ten putative virulence genes (cadF, cj1349, ciaB, mviN, pldA, tlyA, hecA, hecB, irgA, iroE) and antimicrobial susceptibilities. Majority of the isolates harbored mviN (100%), cj1349 (97.2%), ciaB (95.9%), tlyA (91.8%), pldA (91.1%) and cadF (89.7%). Lower detection rates were observed for hecA (10.8%), hecB (19%), iroE (12...
October 3, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29026493/an-uncommon-side-effect-of-a-commonly-used-antibiotic-amoxicillin-clavulanic-acid-induced-hepatitis
#18
Vinay Mathew Thomas, Neena Thomas-Eapen
Amoxicillin-Clavulanic acid continues to be one of the most commonly used antibiotic combinations. Hepatic injury due to this antibiotic is rare. We report a case of amoxicillin-clavulanic acid induced hepatitis causing painless jaundice to bring to attention this rare side effect of this commonly used antibiotic. This is a case of a 62-year-old Caucasian female, who presented with acute onset severe painless jaundice, nausea, vomiting, and pruritus of less than 1-week duration. She had completed a course of amoxicillin-clavulanic acid 3 weeks prior to presentation...
September 2017: Korean Journal of Family Medicine
https://www.readbyqxmd.com/read/29023034/phenotypic-and-molecular-characterization-of-multidrug-resistant-klebsiella-pneumoniae-isolated-from-different-clinical-sources-in-al-najaf-province-iraq
#19
Ahmed Abduljabbar Jaloob Aljanaby, Haneen Mohammed Reda Jaber Alhasnawi
BACKGROUND AND OBJECTIVE: Burns infections and urinary tract infections are the most important prevalent diseases in Asian countries, such as Iraq. Klebsiella pneumoniae is one of the most important bacteria cause this type of infections especially in hospitals. Therefore, the aim of this study was to investigate the prevalence of multi-drug resistance K. pneumoniae and extended-spectrum beta-lactamases producing K. pneumoniae isolates from inpatients with urinary tract infection and burns infections in Al-Kufa hospital in Al-Najaf province, Iraq...
2017: Pakistan Journal of Biological Sciences: PJBS
https://www.readbyqxmd.com/read/28993064/antimicrobial-susceptibility-of-microorganisms-that-cause-urinary-tract-infections-in-pediatric-patients
#20
Jesús Rodríguez-Lozano, Ana de Malet, María Eliecer Cano, Luis de la Rubia, Reinhard Wallmann, Luis Martínez-Martínez, Jorge Calvo
INTRODUCTION: Cumulative susceptibility reports are a valuable tool for the empirical treatment of urinary tract infections, especially in the current context of increasing resistance rates. Our objective was to analyze the antimicrobial susceptibility of bacterial isolates in urine cultures of pediatric patients during a five-year period. METHODS: Retrospective study of urine cultures from 2011 to 2015. Identification and antimicrobial susceptibility tests were performed using the Vitek-2 system (BioMérieux(®)) and categorized according to EUCAST criteria...
October 6, 2017: Enfermedades Infecciosas y Microbiología Clínica
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