keyword
https://read.qxmd.com/read/38457314/do-preinjury-life-events-moderate-the-outcomes-of-mild-traumatic-brain-injuries-in-children-an-a-cap-study
#21
JOURNAL ARTICLE
Safira Dharsee, Ken Tang, Miriam H Beauchamp, William Craig, Quynh Doan, Stephen B Freedman, Jocelyn Gravel, Roger Zemek, Keith Owen Yeates
OBJECTIVE: To examine preinjury life events as moderators of postconcussive symptoms (PCS) and quality of life (QoL) in children with pediatric mild traumatic brain injury (mTBI) versus orthopedic injury (OI). METHODS: Participants were 633 children with mTBI and 334 with OI, ages 8-16.99, recruited from 5 pediatric emergency departments and followed for 6 months postinjury as part of a prospective cohort study. Preinjury life events were measured retrospectively using the Child and Adolescent Survey of Experiences, PCS using the Health and Behavior Inventory (HBI) and Post-Concussion Symptom Interview (PCS-I), and QoL using the Pediatric Quality of Life Inventory (PedsQL)...
March 8, 2024: Journal of Pediatric Psychology
https://read.qxmd.com/read/38452881/screening-for-delirium-during-pediatric-brain-injury-rehabilitation
#22
JOURNAL ARTICLE
William D Watson, Hsuan-Wei Chen, Ana K Ortiz, Adrian M Svingos, Stacy J Suskauer, Sudhin A Shah, Chani Traube
OBJECTIVE: To assess feasibility of routine delirium screening using the Cornell Assessment of Pediatric Delirium (CAPD) in children admitted for rehabilitation with acquired brain injury (ABI), report on the prevalence of positive delirium screens in this population, and explore longitudinal trends in CAPD scores and their association with rehabilitation outcomes. DESIGN: Retrospective study. SETTING: Pediatric inpatient rehabilitation unit...
March 5, 2024: Archives of Physical Medicine and Rehabilitation
https://read.qxmd.com/read/38450641/pediatric-spastic-wrist-contractures-can-be-well-managed-with-wrist-arthrodesis
#23
JOURNAL ARTICLE
Megan Cain, Paige Lemhouse, Cathleen Buckon, Krister P Freese
BACKGROUND: Severe spastic wrist contractures secondary to cerebral palsy (CP) or alike can have significant implications for patient hand function, hygiene, skin breakdown, and cosmesis. When these contractures become rigid, soft tissue procedures alone are unable to obtain or maintain the desired correction. In these patients' wrist arthrodesis is an option-enabling the hand to be stabilized in a more functional position for hygiene, dressing, and general cosmesis, though are patients satisfied? METHODS: All children who had undergone a wrist arthrodesis for the management of a severe wrist contracture at Shriners Hospital, Portland between January 2016 and January 2021 were identified (n=23)...
March 7, 2024: Journal of Pediatric Orthopedics
https://read.qxmd.com/read/38450564/the-australian-traumatic-brain-injury-initiative-systematic-review-and-consensus-process-to-determine-the-predictive-value-of-pre-existing-health-conditions-for-people-with-moderate-severe-traumatic-brain-injury
#24
JOURNAL ARTICLE
Ana Antonic-Baker, Clarissa Auvrez, Gerard Tao, Matthew Bagg, Adelle Gadowski, Ancelin McKimmie, Amelia Hicks, Regina Hill, Lorena Romero, Jennie Ponsford, Natasha A Lannin, Belinda Gabbe, Peter Cameron, D James Cooper, Nick Rushworth, Melinda Fitzgerald, Terence J O'Brien
The first aim of the Australian Traumatic Brain Injury Initiative (AUS-TBI) encompasses development of a set of measures that comprehensively predict outcomes for people with moderate-severe TBI across Australia. This process engaged diverse stakeholders and information sources across six areas: social, health, and clinical factors, biological markers, treatments, and longer-term outcomes. Here, we report the systematic review of pre-existing health conditions as predictors of outcome for people with moderate-severe TBI...
March 7, 2024: Journal of Neurotrauma
https://read.qxmd.com/read/38430714/unmet-health-care-needs-over-the-first-2-years-after-pediatric-traumatic-brain-injury
#25
JOURNAL ARTICLE
Hilde Margrete Dahl, Ingvil Laberg Holthe, Nada Andelic, Marianne Løvstad, Mia C Myhre
AIM: Few studies have addressed how children and adolescents with traumatic brain injuries (TBIs) access health care and educational services. This study aimed to investigate the course of symptoms during the first two years after TBI, whether symptoms implied a need for health care and/or educational services, and the extent of unmet needs. The association between unmet needs and health-related quality of life was also explored. METHODS: This prospective cohort study was conducted at Oslo University Hospital, Norway, from 2015 to 2018...
February 7, 2024: European Journal of Paediatric Neurology: EJPN
https://read.qxmd.com/read/38425208/visualization-of-the-intracranial-pressure-and-time-burden-in-childhood-brain-trauma-what-we-have-learnt-one-decade-on-with-kidsbrainit
#26
JOURNAL ARTICLE
Bavo Kempen, Bart Depreitere, Ian Piper, Juan Sahuquillo, Stefan Mircea Iencean, Hari Krishnan Kanthimathinathan, Julian Zipfel, Arta Barzdina, Stefano Pezzato, Patricia A Jones, Tsz-Yan Milly M Lo
To validate the intracranial pressure (ICP) dose-response visualization plot for the first time in a novel prospectively collected pediatric traumatic brain injury (pTBI) data set from the multi-center multi-national KidsBrainIT consortium. Prospectively collected minute-by-minute ICP and mean arterial blood pressure time series of 104 pTBI patients were categorized in ICP intensity-duration episodes. These episodes were correlated with the 6-month Glasgow Outcome Score (GOS) and displayed in a color-coded ICP dose-response plot...
February 29, 2024: Journal of Neurotrauma
https://read.qxmd.com/read/38407975/impact-of-sex-and-pubertal-development-on-anxiety-in-adolescents-following-concussion
#27
JOURNAL ARTICLE
Dean Gomes, Shawn R Eagle, Bindal Makwana Mehmel, Theodore John Albrecht, Amelia L Versace, João Paulo Lima Santos, Alicia Morgan Trbovich, Richelle Stiffler, Laramie Martinez, Cynthia L Holland, Aaron James Zynda, Michael W Collins, Anthony P Kontos
Concussion often results in psychological symptoms, including anxiety. Post-concussion anxiety has been well-documented, although much of this research has focused on collegiate athletes. The purpose of this study was to compare 1) anxiety symptoms in concussed and healthy controls over time, and 2) to explore sex differences in post-concussion anxiety within the context of pubertal development. Participants (N=126, mean age = 15.1 years old), including concussed (n=86) and healthy adolescents (n=40), completed the Pubertal Development Scale (PDS) and the Screen for Child Anxiety and Related Disorders (SCARED-C)...
February 26, 2024: Journal of Neurotrauma
https://read.qxmd.com/read/38405592/current-practice-of-intracranial-pressure-monitoring-in-children-with-severe-traumatic-brain-injury-a-nationwide-prospective-surveillance-study-in-germany
#28
JOURNAL ARTICLE
Pia Brensing, Sandra Greve, Rayan Hojeij, Philipp Dammann, Ursula Felderhoff-Müser, Christian Dohna-Schwake, Nora Bruns
BACKGROUND: For management of severe traumatic brain injuries (sTBI) in children, the overall level of evidence to guide diagnostic and therapeutic procedures is low. Since 2016, international guidelines have subsequently suggested invasive intracranial pressure (ICP) monitoring in patients with initial Glasgow Coma Scale (GCS) ≤8. In Germany, ICP monitoring was an individual case decision from 2011 until the 2022 update of the German pediatric TBI guideline. The aim of this study was to evaluate current clinical practice of invasive ICP monitoring in Germany in children <10 years with respect to guideline recommendations...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38404523/blood-brain-barrier-dysfunction-predicts-microglial-activation-after-traumatic-brain-injury-in-juvenile-rats
#29
JOURNAL ARTICLE
Tabitha R F Green, Tina Nguyen, Veronika Dunker, Danielle Ashton, J Bryce Ortiz, Sean M Murphy, Rachel K Rowe
Traumatic brain injury (TBI) disrupts the blood-brain barrier (BBB), which may exacerbate neuroinflammation post-injury. Few translational studies have examined BBB dysfunction and subsequent neuroinflammation post-TBI in juveniles. We hypothesized that BBB dysfunction positively predicts microglial activation and that vulnerability to BBB dysfunction and associated neuroinflammation are dependent on age at injury. Post-natal day (PND)17 and PND35 rats ( n  = 56) received midline fluid percussion injury or sham surgery, and immunoglobulin-G (IgG) stain was quantified as a marker of extravasated blood in the brain and BBB dysfunction...
2024: Neurotrauma reports
https://read.qxmd.com/read/38400951/parent-and-provider-differences-in-ratings-of-mental-health-and-neurodevelopmental-concerns-in-children-with-neurologic-disorders
#30
JOURNAL ARTICLE
Jessica M Schwartzman, Zachary J Williams, Andrew E Molnar
Children with neurologic disorders face increased risks for mental health and neurodevelopmental conditions, with information often limited to parent report. To better understand mental health and neurodevelopmental needs in this population, a retrospective chart review of a convenience sample of children with neurologic disorders referred for a neuropsychological evaluation was conducted in the present study to explore interrater agreement between care team members (referring providers, parents, pediatric neuropsychologist)...
February 24, 2024: Journal of Clinical Psychology in Medical Settings
https://read.qxmd.com/read/38397427/brain-derived-neurotrophic-factor-in-pediatric-acquired-brain-injury-and-recovery
#31
REVIEW
Amery Treble-Barna, Bailey A Petersen, Zachary Stec, Yvette P Conley, Ericka L Fink, Patrick M Kochanek
We review emerging preclinical and clinical evidence regarding brain-derived neurotrophic factor (BDNF) protein, genotype, and DNA methylation (DNAm) as biomarkers of outcomes in three important etiologies of pediatric acquired brain injury (ABI), traumatic brain injury, global cerebral ischemia, and stroke. We also summarize evidence suggesting that BDNF is (1) involved in the biological embedding of the psychosocial environment, (2) responsive to rehabilitative therapies, and (3) potentially modifiable. BDNF's unique potential as a biomarker of neuroplasticity and neural repair that is reflective of and responsive to both pre- and post-injury environmental influences separates it from traditional protein biomarkers of structural brain injury with exciting potential to advance pediatric ABI management by increasing the accuracy of prognostic tools and informing clinical decision making through the monitoring of therapeutic effects...
February 4, 2024: Biomolecules
https://read.qxmd.com/read/38394651/near-infrared-spectroscopy-monitoring-in-severe-pediatric-abusive-head-trauma
#32
JOURNAL ARTICLE
Shih-Shan Lang, Nankee K Kumar, Raphia Rahman, Alexander Tucker, Tracy M Flanders, Gregory G Heuer, Phillip B Storm, Chao Zhao, Jimmy W Huh
OBJECTIVE: Abusive head trauma (AHT) is one of the most devastating forms of pediatric traumatic brain injury (TBI). It commonly presents with seizures, which may contribute to poor neurological outcome following trauma. Noninvasive near-infrared spectroscopy (NIRS) neuromonitoring may provide information on cerebral oxygenation and perfusion. In this study, the authors evaluated whether NIRS regional cerebral oxygen saturation (rSO2) values were associated with seizure activity confirmed by electroencephalography (EEG) and whether NIRS neuromonitoring could aid in seizure detection in patients with severe AHT...
February 23, 2024: Journal of Neurosurgery. Pediatrics
https://read.qxmd.com/read/38388283/pediatric-traumatic-brain-injury-outcomes-and-disparities-during-the-covid-19-pandemic
#33
JOURNAL ARTICLE
Rachel C Kim, Priya Aggarwal, Regina Kuhia, Anthony J Sochan, Zirun Zhao, Susan Fiore, David Chesler, Héctor E Alcalá, Helen Hsieh
BACKGROUND: To study the impact of the COVID-19 pandemic on traumatic brain injury (TBI) patient demographic, clinical and trauma related characteristics, and outcomes. METHODS: Retrospective chart review was conducted on pediatric TBI patients admitted to a Level I Pediatric Trauma Center between January 2015 and June 2022. The pre-COVID era was defined as January 1, 2015, through March 12, 2020. The COVID-19 era was defined as March 13, 2020, through June 30, 2022...
February 1, 2024: Journal of Pediatric Surgery
https://read.qxmd.com/read/38383868/takotsubo-syndrome-linked-to-paroxysmal-sympathetic-hyperactivity-as-a-postoperative-complication-after-brain-tumor-removal-a-case-report-and-literature-review
#34
JOURNAL ARTICLE
Manel Krouma, A Aboudou Soilihi, Gregoire Pech-Gourg, Sophie Arnaud, El Louali Fadoua, Caruselli Marco, Didier Scavarda
Paroxysmal sympathetic hyperactivity (PSH) is a relatively common syndrome typically observed following traumatic brain injury (TBI). It manifests through a combination of non-specific symptoms that collectively define its presentation. Linked to sympathetic hyperactivity, takotsubo syndrome is a cardiomyopathy marked by left ventricular dysfunction and may coincide with PSH. While various factors can lead to the simultaneous occurrence of these syndromes, a notably rare scenario involves their manifestation after brain tumor removal...
February 22, 2024: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://read.qxmd.com/read/38379310/long-term-burden-of-informal-caregiver-7-years-after-severe-childhood-traumatic-brain-injury-in-the-traumatisme-grave-de-l-enfant-tge-study
#35
JOURNAL ARTICLE
Gregorio Sorrentino, Eléonore Bayen, Hugo Câmara-Costa, Leila Francillette, Hanna Toure, Anne Laurent-Vannier, Philippe Meyer, Georges Dellatolas, Mathilde Chevignard
OBJECTIVE: To investigate reported burden by the Primary Family Caregiver (PFC) 7-years after severe pediatric traumatic brain injury in the TGE (Traumatisme Grave de l'Enfant) longitudinal study. METHODS: Subjective burden was estimated with the Zarit Burden Inventory (ZBI) in 36 PFC (parents), who rated their own health status (Medical Outcome Study Short Form-12), family functioning and their child's level of care and needs (Pediatric/Adult Care And Needs Scale [PCANS/CANS])...
February 20, 2024: Brain Injury
https://read.qxmd.com/read/38374629/effects-of-transport-to-trauma-centers-on-survival-outcomes-among-severe-trauma-patients-in-korea-nationwide-age-stratified-analysis
#36
JOURNAL ARTICLE
Hakrim Kim, Kyoung Jun Song, Ki Jeong Hong, Jeong Ho Park, Tae Han Kim, Stephen Gyung Won Lee
BACKGROUND: Previous studies showed that the prognosis for severe trauma patients is better after transport to trauma centers compared to non-trauma centers. However, the benefit from transport to trauma centers may differ according to age group. The aim of this study was to compare the effects of transport to trauma centers on survival outcomes in different age groups among severe trauma patients in Korea. METHODS: Cross-sectional study using Korean national emergency medical service (EMS) based severe trauma registry in 2018-2019 was conducted...
February 19, 2024: Journal of Korean Medical Science
https://read.qxmd.com/read/38367484/evaluation-of-quantitative-pupillometry-in-acute-postinjury-pediatric-concussion
#37
JOURNAL ARTICLE
Theodore Heyming, Chloe Knudsen-Robbins, John Schomberg, Jennifer Hayakawa, Bryan Lara, Kellie Bacon, Brooke Valdez, Maxwell Wickens, Shelby K Shelton, Jonathan Romain, Elizabeth Wallace, Sharief Taraman, William Loudon, Rachel Pearson
BACKGROUND: Although millions of children sustain concussions each year, a rapid and objective test for concussion has remained elusive. The aim of this study was to investigate quantitative pupillometry in pediatric patients in the acute, postinjury setting. METHODS: This was a prospective case-control study of concussed patients presenting to the emergency department within 72 hours of injury. Pupillary measurements were gathered using NeurOptics' PLR 3000; evaluation included a symptom checklist and neurocognitive assessment...
April 2024: Pediatric Neurology
https://read.qxmd.com/read/38364490/diffuse-axonal-injury-on-magnetic-resonance-imaging-and-its-relation-to-neurological-outcomes-in-pediatric-traumatic-brain-injury
#38
JOURNAL ARTICLE
Tarek Hazwani, Ahmed M Khalifa, Moutasem Azzubi, Abdullah Alhammad, Abdullah Aloboudi, Ahmad Jorya, Arwa Alkhuraiji, Sarah Alhelabi, Naila Shaheen
OBJECTIVE: Diffuse axonal injury (DAI), a frequent consequence of pediatric traumatic brain injury (TBI), presents challenges in predicting long-term recovery. This study investigates the relationship between the severity of DAI and neurological outcomes in children. METHODS: We conducted a retrospective analysis of 51 pediatric TBI patients diagnosed with DAI using Adam's classification. Neurological function was assessed at 2, 3, and 6 weeks, and 12 months post-injury using the Pediatric Glasgow Outcome Scale-Extended (PGOSE)...
February 2024: Clinical Neurology and Neurosurgery
https://read.qxmd.com/read/38364231/differences-in-clinical-outcomes-and-resource-utilization-in-pediatric-traumatic-brain-injury-between-countries-of-different-sociodemographic-indices
#39
JOURNAL ARTICLE
Keith Wei Han Liang, Jan Hau Lee, Syeda K Qadri, Janani Nadarajan, Paula Caporal, Juan D Roa G, Sebastián González-Dambrauskas, Qalab Abbas, Yasser Kazzaz, Shu-Ling Chong
OBJECTIVE: The burden of traumatic brain injury (TBI) is disproportionately high in low- and middle-income countries (LMICs). This study aimed to compare clinical outcomes and healthcare utilization for children with moderate to severe TBIs between LMICs and non-LMICs in Asia and Latin America. METHODS: The authors performed an observational multicenter study from January 2014 to February 2023 among children with moderate to severe TBIs admitted to participating pediatric intensive care units (PICUs) in the Pediatric Acute and Critical Care Medicine Asian Network (PACCMAN) and Red Colaborativa Pediátrica de Latinoamérica (LARed Network)...
February 16, 2024: Journal of Neurosurgery. Pediatrics
https://read.qxmd.com/read/38360517/clinical-epidemiology-of-extracranial-injuries-in-severe-pediatric-traumatic-brain-injury-in-south-america
#40
JOURNAL ARTICLE
Miguel Castro, Lauren L Agoubi, Julia Velonjara, Claudia Lutkevicius, Nahuel Guadagnoli, Silvia Lujan, Gustavo Petroni, Michael J Bell, Monica S Vavilala, Charles Mock
BACKGROUND: Severe traumatic brain injury (TBI) is a leading cause of pediatric mortality, with a disproportionate burden on low- and middle-income countries. The impact of concomitant extracranial injury (ECI) on these patients remains unclear. This study is the first to characterize the epidemiology and clinical course of severe pediatric TBI with extracranial injuries in any South American country. METHODS: We conducted a secondary analysis of baseline data collected prior to implementation of a clinical trial on TBI care in Argentina, Paraguay, and Chile from September 2019 to July 2020...
February 10, 2024: Injury
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