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Kadri Murat Gurses, Duygu Kocyigit, Muhammed Ulvi Yalcin, Hande Canpinar, Banu Evranos, Ugur Canpolat, Hikmet Yorgun, Levent Sahiner, Dicle Guc, Kudret Aytemir
BACKGROUND: Atrial fibrillation(AF) is the most common sustained arrhythmia. Its most feared sequelae are stroke and peripheral thromboembolism due to atrial thrombi formation. Mechanisms underlying the relationship between platelet activation and left atrial thrombi have not been clearly elucidated yet. We aimed to investigate whether immune-mediated platelet activation occurred in AF patients in this cross-sectional study. METHODS: Persistent and paroxysmal AF patients who underwent cryoballoon-based AF ablation between March 2015 and July 2016 were included as the patient group...
January 8, 2018: Cytokine
Xiaoliang Zhao, Daniela Lenek, Ugur Dag, Barry Dickson, Krystyna Keleman
Recurrent connections are thought to be a common feature of the neural circuits that encode memories, but how memories are laid down in such circuits is not fully understood. Here we present evidence that courtship memory in Drosophila relies on the recurrent circuit between mushroom body gamma (MBg), M6 output, and aSP13 dopaminergic neurons. We demonstrate persistent neuronal activity of aSP13 neurons and show that it transiently potentiates synaptic transmission from MBγ>M6 neurons. M6 neurons in turn provide input to aSP13 neurons, prolonging potentiation of MBγ>M6 synapses over time periods that match short-term memory...
January 11, 2018: ELife
Vedat Hekimsoy, Ergun Barıs Kaya, Ali Akdogan, Levent Sahiner, Banu Evranos, Ugur Canpolat, Kudret Aytemir, Necla Özer, Lale Tokgozoglu
Systemic sclerosis (SSc) is a generalized connective tissue disorder, and SSc patients are at risk of developing pulmonary arterial hypertension (PAH). The aims of this study are to evaluate the right ventricular regional systolic function using two-dimensional speckle-tracking echocardiography (2D STE) and to determine the predictive ability of peak longitudinal systolic strain (PLSS) at the RV lateral wall for PAH in SSc patients. 80 SSc patients (mean age 51 ± 12 years) were included in the study. Echocardiography and 2D STE were performed at baseline and after 12 months...
January 10, 2018: International Journal of Cardiovascular Imaging
Akif Goktug Bozkurt, Guluzar Gorkem Buyukgoz, Mehmet Soforoglu, Ugur Tamer, Zekiye Suludere, Ismail Hakki Boyaci
In this study, a sandwich immunoassay method utilizing enzymatic activity of alkaline phosphatase (ALP) on 5-bromo-4-chloro-3-indolyl phosphate (BCIP) for Escherichia coli (E. coli) detection was developed using surface enhanced Raman spectroscopy (SERS). For this purpose, spherical magnetic gold coated core-shell nanoparticles (MNPs-Au) and rod shape gold nanoparticles (Au-NRs) were synthesized and modified for immunomagnetic separation (IMS) of E. coli from the solution. In order to specify the developed method to ALP activity, Au-NRs were labeled with this enzyme...
December 21, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Ugur Karban, Christophe Schram
The noise generated by a ducted diaphragm configuration, taken in this paper as a prototype aeroacoustic system, is investigated experimentally using a two-port source identification method [Lavrentjev, Åbom, and Bodén (1995) J. Sound Vib. 183, 517-531]. The method requires successively the determination of the so-called passive scattering properties of the ducted diaphragm system using loudspeakers, and the extraction of the active noise that would be emitted by the aeroacoustic source itself in an anechoic duct...
December 2017: Journal of the Acoustical Society of America
Ugur Korkut Pata
This paper examines the dynamic short- and long-term relationship between per capita GDP, per capita energy consumption, financial development, urbanization, industrialization, and per capita carbon dioxide (CO2) emissions within the framework of the environmental Kuznets curve (EKC) hypothesis for Turkey covering the period from 1974 to 2013. According to the results of the autoregressive distributed lag bounds testing approach, an increase in per capita GDP, per capita energy consumption, financial development, urbanization, and industrialization has a positive effect on per capita CO2 emissions in the long term, and also the variables other than urbanization increase per capita CO2 emissions in the short term...
December 29, 2017: Environmental Science and Pollution Research International
Aysegul Ozer, Ugur Uzuner, Halil Ibrahim Guler, Fulya Ay Sal, Ali Osman Belduz, Ilhan Deniz, Sabriye Canakci
Chemical bleaching process of paper pulps gives off excessive amount of chlorinated organic wastes mostly released to environment without exposing complete bioremediaton. Recent alternative and eco-friendly approaches towards pulp bleaching appear more responsive to environmental awareness. Here we report, direct use of a recombinant Bacillus subtilis bacterium for pulp bleaching, endowed with three ligninolytic enzymes from various bacteria. In addition, efficient bleaching performance from GST biocatalyst tested for the first-time in pulp bleaching applications was also achieved...
December 29, 2017: Biotechnology and Applied Biochemistry
Aynur Sahin, M Aylin Arici, Yeliz Yılmaz, Sule Kalkan, Nergiz Durmus, Bekir Ugur Ergur, İlkay Aksu, Neşe Atabey, Yesim Tuncok
Amanita phalloides species mushrooms containing alpha amanitin (α-AMA) are responsible for the majority of fatal mushroom intoxications and can lead to severe poisonings resulting in hepatotoxicity and acute hepatic failure. Existing antidotes, such as silibinin, are not sufficiently effective in the prevention and/or resolution of α-AMA-induced hepatotoxicity. We investigated the effects of resveratrol on α-AMA-induced hepatotoxicity and compared with silibinin, a known antidote using in vivo and in vitro toxicity models...
December 29, 2017: Basic & Clinical Pharmacology & Toxicology
Berrak Ugur, Huan Bao, Michal Stawarski, Lita R Duraine, Zhongyuan Zuo, Yong Qi Lin, G Gregory Neely, Gregory T Macleod, Edwin R Chapman, Hugo J Bellen
Neurotransmission is a tightly regulated Ca2+-dependent process. Upon Ca2+ influx, Synaptotagmin1 (Syt1) promotes fusion of synaptic vesicles (SVs) with the plasma membrane. This requires regulation at multiple levels, but the role of metabolites in SV release is unclear. Here, we uncover a role for isocitrate dehydrogenase 3a (idh3a), a Krebs cycle enzyme, in neurotransmission. Loss of idh3a leads to a reduction of the metabolite, alpha-ketoglutarate (αKG), causing defects in synaptic transmission similar to the loss of syt1...
December 26, 2017: Cell Reports
Tobias Fehlmann, Christina Backes, Julia Alles, Ulrike Fischer, Martin Hart, Fabian Kern, Hilde Langseth, Trine Rounge, Sinan Ugur Umu, Mustafa Kahraman, Thomas Laufer, Jan Haas, Cord Staehler, Nicole Ludwig, Matthias Hübenthal, Benjamin Meder, Andre Franke, Hans-Peter Lenhof, Eckart Meese, Andreas Keller
Motivation: While the amount of small non-coding RNA sequencing data is continuously increasing, it is still unclear to which extent small RNAs are represented in the human genome. Results: In this study we analyzed 303 billion sequencing reads from nearly 25,000 data sets to answer this question. We determined that 0.8% of the human genome are reliably covered by 874,123 regions with an average length of 31nt. On the basis of these regions, we found that among the known small non-coding RNA classes, microRNAs were the most prevalent...
December 21, 2017: Bioinformatics
Lutfu Askin, Hakan Tasolar, Ugur Aksu, Mustafa Cetin, Abdulkadir Uslu, Halil I Tanboga, Serdar Turkmen, Erdal Akturk
INTRODUCTION: Hypertension can cause anatomic changes in the left ventricle, generally leading to abnormal geometry. High-sensitivity cardiac troponin T (hs-cTnT) values have been shown to be positively correlated with left ventricular hypertrophy in hypertensive patients. The current study investigated the diagnostic value of hs-cTnT in patient with nondipper hypertension (NDH) as well as determined the correlation between left ventricular geometric patterns and hs-cTnT values in hypertensive patients...
February 2018: Blood Pressure Monitoring
Annette B Vogel, Laura Lambert, Ekaterina Kinnear, David Busse, Stephanie Erbar, Kerstin C Reuter, Lena Wicke, Mario Perkovic, Tim Beissert, Heinrich Haas, Stephen T Reece, Ugur Sahin, John S Tregoning
New vaccine platforms are needed to address the time gap between pathogen emergence and vaccine licensure. RNA-based vaccines are an attractive candidate for this role: they are safe, are produced cell free, and can be rapidly generated in response to pathogen emergence. Two RNA vaccine platforms are available: synthetic mRNA molecules encoding only the antigen of interest and self-amplifying RNA (sa-RNA). sa-RNA is virally derived and encodes both the antigen of interest and proteins enabling RNA vaccine replication...
December 5, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
Zeynep Oşar Siva, Derya Uluduz, Fatma Ela Keskin, Feyza Erenler, Huriye Balcı, Uğur Uygunoğlu, Sabahattin Saip, Baki Göksan, Aksel Siva
Background Chronic migraine has a well-documented association with increased insulin resistance and metabolic syndrome. The hypothalamus may play a role in the progression of insulin resistance in chronic migraine through the regulation of orexigenic peptides such as neuropeptide Y. Insulin resistance may lead to increased risk of future type 2 diabetes mellitus in patients with chronic migraine, which is more likely to occur if other pathogenetic defects of type 2 diabetes mellitus, such as impaired pancreatic β-cell functions and defects in intestinal glucagon-like peptide-1 secretion after meals...
January 1, 2017: Cephalalgia: An International Journal of Headache
Lütfi Soylu, Oğuz Uğur Aydın, Mustafa Cesur, Serdar Özbaş, Selçuk Hazinedaroğlu
Acute hypokalemic paralysis is a relatively rare cause of acute weakness. It may resolve spontaneously; however, it may be a potential life-threatening condition. Hypertension may be considered the most important finding in combination with hypokalemic paralysis for raising the suspicion of primary hyperaldosteronism (PHA). A 55-year-old hypertensive Mexican woman was admitted to the Emergency Unit with a sudden onset of generalized paralysis. An endocrinological workup and an abdominal magnetic resonance imaging revealed PHA with a 1...
2017: Turkish Journal of Surgery
Ugur Aydin, Emrah Karataslioglu
Background: Canal transportation is a common sequel caused by rotary instruments. Aims: The purpose of the present study is to evaluate the degree of transportation after the use of Reciproc single-file instruments with or without glide path files. Methods: Thirty resin blocks with L-shaped canals were divided into three groups (n = 10). Group 1 - canals were prepared with Reciproc-25 file. Group 2 - glide path file-G1 was used before Reciproc...
July 2017: Journal of Conservative Dentistry: JCD
Merve Guzeldulger Ugur, Ruhusen Kutlu, Ibrahim Kilinc
BACKGROUND AND AIMS: Chronic Obstructive Pulmonary Disease(COPD) is a type of obstructive lung disease characterized by long-term poor airflow. Tobacco smoking is the most common cause of COPD. In this study, we aimed to assess thevasculerendothelial growth factor (VEGF) and inflammation markers on smokers and non-smoking individuals. METHODS: Our study was a case-control study and 175 individuals who want to give up smoking constituted the case group. As a control group, 175 individuals who never smoked...
December 15, 2017: Clinical Respiratory Journal
Hüseyin Çağlayan Özcan, Mete Gurol Uğur, Özcan Balat, Seyhun Sucu, Neslihan Bayramoğlu Tepe, Ebru Öztürk, Özge Kömürcü Karuserci, Tanyeli Güneyligil Kazaz
PURPOSE: Our aim was to evaluate the association of cystic hygroma (CH) with fetal malformations and also to investigate the outcome of fetuses with CH diagnosed in the prenatal period. METHODS: We divided the CH patients into two main groups as isolated CH or CH associated with the congenital structural abnormality (CSA) by measuring the thickness of CH and showing other fetal abnormalities. Pregnancy outcomes were recorded as spontaneous abortion, elective termination, intrauterine death, live birth, postnatal death, and lost to follow-up...
December 27, 2017: Journal of Maternal-fetal & Neonatal Medicine
Christian Brogna, Matthias Millesi, Leslie Fiengo, Mark Richardson, Ranjeev Bhangoo, Keyoumars Ashkan, Ugur Türe
No abstract text is available yet for this article.
December 12, 2017: Neurosurgery
Rui Manilha, Volkan M Harput, Ugur Türe
No abstract text is available yet for this article.
December 12, 2017: Operative Neurosurgery (Hagerstown, Md.)
Yusuf Emes, Uğur Aga, Anil Cesur, Merva Soluk-Tekkesin, Büket Aybar, Canan Alatli
Odontogenic keratocyst (OKC) is a clinically aggressive developmental odontogenic cyst with a high recurrence rate as 62%. Oroantral communication (OAC) is a gateway through the maxillary sinus and the oral cavity, which, if not treated, will develop into oroantral fistula or chronical sinus diseases. Different methods for closure of OAC were described but only few of them have common usage. In recent years, the use of a pedicled buccal fat pad (BFP) in closure of large oroantral defects has been become popular...
December 12, 2017: Journal of Craniofacial Surgery
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