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https://www.readbyqxmd.com/read/28527030/intravitreal-erythropoietin-injection-in-late-stage-optic-neuropathy-a-safety-study-on-human
#1
Ugur Acar, Bekir Kucuk, Mehmet Koray Sevinc, Seckin Aykas, Mesut Erdurmus, Gungor Sobaci
AIM: To evaluate the whether intravitreal erythropoietin (EPO) administration has any beneficial or adverse effect in patients with late-stage optic neuropathy (ON) or not. METHODS: The study examined 16 eyes of 16 patients who had late-stage ON and ≥1/20 best-corrected visual acuity (BCVA) in their affected eye. There were nonarteritic ischemic ON in 10 (62.5%) eyes, traumatic ON in 4 (25.0%) eyes and methanol-induced ON in 2 (12.5%) eyes. Using pars plana approach, 2000 IU/0...
May 19, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28509375/chronic-nicotine-induced-changes-in-gene-expression-of-delta-and-kappa-opioid-receptors-and-their-endogenous-ligands-in-the-mesocorticolimbic-system-of-the-rat
#2
Muzeyyen Ugur, Egemen Kaya, Oguz Gozen, Ersin O Koylu, Lutfiye Kanit, Aysegul Keser, Burcu Balkan
Delta and kappa opioid receptors (DOR and KOR, respectively) and their endogenous ligands, proenkephalin (PENK) and prodynorphin (PDYN)-derived opioid peptides are proposed as important mediators of nicotine reward. The present study investigated the regulatory effect of chronic nicotine treatment on the gene expression of DOR, KOR, PENK and PDYN in the mesocorticolimbic system. Three groups of rats were injected subcutaneously with nicotine at doses of 0.2, 0.4 or 0.6 mg/kg/day for six days. Rats were decapitated one hour after the last dose on day six, as this timing coincides with increased dopamine release in the mesocorticolimbic system...
May 16, 2017: Synapse
https://www.readbyqxmd.com/read/28508245/evaluation-of-macular-and-peripapillary-choroidal-thickness-macular-volume-and-retinal-nerve-fiber-layer-in-acromegaly-patients
#3
Serpil Yazgan, Dilek Arpaci, Haci Ugur Celik, Irem Isik
PURPOSE: To evaluate macular volume, retinal nerve fiber layer, and macular and peripapillary choroidal thickness in acromegaly patients. METHOD: In this prospective, case-control study, 31 patients with acromegaly and 32 healthy subjects were recruited. Only right eyes were evaluated. Macular choroidal thickness (CT) was measured at three points, peripapillary CT was measured at eight points, and macular volume was measured at nine areas in the central 6 mm circle zone by spectraldomain optical coherence tomography (OCT)...
May 15, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28492788/hemoglobin-a1c-levels-predicts-acute-kidney-injury-after-coronary-artery-bypass-surgery-in-non-diabetic-patients
#4
Cevdet Ugur Kocogulları, Atike Tekeli Kunt, Rezan Aksoy, Cagrı Duzyol, Hakan Parlar, Huseyin Saskın, Orhan Fındık
INTRODUCTION: Elevated hemoglobin A1c levels in patients with diabetes mellitus have been known as a risk factor for acute kidney injury after coronary artery bypass grafting. However, the relationship between hemoglobin A1c levels in non-diabetics and acute kidney injury is under debate. We aimed to investigate the association of preoperative hemoglobin A1c levels with acute kidney injury in non-diabetic patients undergoing isolated coronary artery bypass grafting. METHODS: 202 non-diabetic patients with normal renal function (serum creatinine <1...
March 2017: Brazilian Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/28492152/effect-of-stone-composition-on-the-outcomes-of-semi-rigid-ureteroscopy-using-holmium-yttrium-aluminum-garnet-laser-or-pneumatic-lithotripsy
#5
Mustafa Kadihasanoglu, Ugur Yucetas, Mehmet Gokhan Culha, Erkan Erkan, Mahmut Gokhan Toktas
OBJECTIVE: To compare the effectiveness of laser lithotripsy (LL) and pneumatic lithotripters (PL) in calcium oxalate (CaOx) and calcium phosphate (CaP) stones and assess whether these stone compositions affect the outcomes of LL and PL. STUDY DESIGN: Comparative, descriptive study. PLACE AND DURATION OF STUDY: Istanbul Training and Research Hospital, Turkey, from August 2010 to August 2015. METHODOLOGY: A total of 114 patients underwent ureteroscopy using LL and PL...
April 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28490348/an-international-reproducibility-study-validating-quantitative-determination-of-erbb2-esr1-pgr-and-mki67-mrna-in-breast-cancer-using-mammatyper%C3%A2
#6
Zsuzsanna Varga, Annette Lebeau, Hong Bu, Arndt Hartmann, Frederique Penault-Llorca, Elena Guerini-Rocco, Peter Schraml, Fraser Symmans, Robert Stoehr, Xiaodong Teng, Andreas Turzynski, Reinhard von Wasielewski, Claudia Gürtler, Mark Laible, Kornelia Schlombs, Heikki Joensuu, Thomas Keller, Peter Sinn, Ugur Sahin, John Bartlett, Giuseppe Viale
BACKGROUND: Accurate determination of the predictive markers human epidermal growth factor receptor 2 (HER2/ERBB2), estrogen receptor (ER/ESR1), progesterone receptor (PgR/PGR), and marker of proliferation Ki67 (MKI67) is indispensable for therapeutic decision making in early breast cancer. In this multicenter prospective study, we addressed the issue of inter- and intrasite reproducibility using the recently developed reverse transcription-quantitative real-time polymerase chain reaction-based MammaTyper® test...
May 11, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28489372/psi4-1-1-an-open-source-electronic-structure-program-emphasizing-automation-advanced-libraries-and-interoperability
#7
Robert M Parrish, Lori A Burns, Daniel G A Smith, Andrew C Simmonett, A Eugene DePrince, Edward G Hohenstein, Ugur Bozkaya, Alexander Yu Sokolov, Roberto Di Remigio, Ryan Matthew Richard, Jérôme F Gonthier, Andrew M James, Harley R McAlexander, Ashutosh Kumar, Masaaki Saitow, Xiao Wang, Benjamin P Pritchard, Prakash Verma, Henry F Schaefer, Konrad Patkowski, Rollin A King, Edward F Valeev, Francesco A Evangelista, Justin M Turney, T Daniel Crawford, C David Sherrill
Psi4 is an ab initio electronic structure program providing methods such as Hartree-Fock, density functional theory, configuration interaction, and coupled-cluster theory. The 1.1 release represents a major update meant to automate complex tasks, such as geometry optimization using complete-basis-set extrapolation or focal-point methods. Conversion of the top-level code to a Python module means that Psi4 can now be used in complex workflows alongside other Python tools. Several new features have been added with the aid of libraries providing easy access to techniques such as density fitting, Cholesky decomposition, and Laplace denominators...
May 10, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28489156/impact-of-free-thyroxine-levels-and-other-clinical-factors-on-bare-metal-stent-restenosis
#8
Uğur Canpolat, Osman Turak, Fırat Özcan, Fatih Öksüz, Mehmet Ali Mendi, Çağrı Yayla, Sinan Aydoğdu
Objective: Thyroid hormones have both direct and indirect effects on thermogenesis such as modulating vascular smooth muscle cell proliferation. However, the influence of more subtle changes in thyroid hormones on coronary atherosclerosis remains a matter of speculation. Smooth muscle cells play a crucial role in the pathogenesis of in-stent restenosis (ISR). However, the relationship between free thyroxine (fT4) and ISR has not been studied. In the present study, we aimed to assess the role of preprocedural serum fT4 level on the development of ISR in patients undergoing coronary bare metal stent (BMS) implantation...
March 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28486017/a-rare-cause-of-pulmonary-embolism-hydatid-cyst
#9
Goktug Savas, Muharrem Said Cosgun, Ugur Karabiyik, Abdurrahman Oguzhan
No abstract text is available yet for this article.
May 9, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28485304/synthesis-of-polymer-bead-nano-necklaces-on-aligned-carbon-nanotube-scaffolds
#10
Noa Lachman, Itai Y Stein, Asli Ugur, Dale Lidston, Karen Gleason, Brian Wardle
Here, we report the fabrication of aligned carbon nanotube (A-CNT)/conducting polymer (CP) heterostructures with both uniform conformal and periodic beaded polymer morphologies <i>via</i> oxidative chemical vapor deposition of poly(ethylenedioxythiophene). Periodic beaded CP morphologies are realized utilizing the Plateau-Rayleigh instability to transform the original uniform conformal film, yielding a beaded CP morphology with a > 50% enhancement in specific surface area. Modeling indicates that this specific surface area increase originates from the internal volume of the A-CNTs becoming available for adsorption, and that these internal A-CNT surfaces, if they could be made accessible to electrolyte ions, could lead to > 30% enhancement of specific gravimetric and volumetric capacitances of current state-of-the-art A-CNT/CP heterostructures...
May 9, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28484530/neglected-knowledge-asymmetric-features-of-lumbar-disc-disease
#11
Ayhan Kanat, Ugur Yazar, Bulent Ozdemir, Hizir Kazdal, Mehmet Sabri Balik
BACKGROUND: Lumbar disc herniations have been extensively studied in the literature. Asymmetric trunk muscle anatomy could affect the development of this entity which has never been quantitatively studied previously. The purpose of this manuscript was to analyze the operated sides of herniated lumbar disc. MATERIALS AND METHODS: Data files of patients with lumbar disc herniation operated in author's hospital between January 2007 and March 2009 were analyzed. RESULTS: In operated side analysis, discectomy side was 53% on the left side, 40% on the right side, the difference between two sides was statistically significant...
April 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28481742/ultraprotective-ventilation-during-cpb-protects-the-alveolar-capillary-barrier-in-pulmonary-normotensive-congenital-heart-patients
#12
Ugur Gocen, Atakan Atalay
BACKGROUND: Alveolar-capillary membrane damage develops as a result of the inflammatory effect of cardiopulmonary bypass (CPB). In the presence of a healthy alveolar-capillary barrier, there is little or no surfactant in the blood. The aim of this study was to evaluate the protective effects of ultraprotective ventilation during CPB by measuring serum and bronchoalveolar lavage (BAL) surfactant protein B (SPB) values in congenital heart surgery. METHODS: This prospective study was designed for 46 patients with congenital heart defects...
May 1, 2017: Heart Surgery Forum
https://www.readbyqxmd.com/read/28476986/biosynthesis-of-silver-nanoparticles-by-streptomyces-griseorubens-isolated-from-soil-and-their-antioxidant-activity
#13
Tuba Baygar, Aysel Ugur
Microbial mediated biological synthesis of metallic nanoparticles was carried out ecofriendly in the present study. Silver nanoparticles (AgNPs) were extracellularly biosynthesised from Streptomyces griseorubens AU2 and extensively characterised by ultraviolet-visible (UV-vis) and Fourier transform infrared spectroscopy, high-resolution transmission electron microscopy, scanning electron microscopy and X-ray diffraction analysis. Elemental analysis of nanoparticles was also carried out using energy dispersive X-ray spectroscopy...
April 2017: IET Nanobiotechnology
https://www.readbyqxmd.com/read/28471131/primary-ovarian-fibrosarcoma-a-case-report-and-review-of-the-literature
#14
Ozhan Ozdemır, Mustafa Erkan Sarı, Ertugrul Sen, Bunyamin Ugur Ilgın, Servet Gurescı, Cemal Resat Atalay
OBJECTIVES: Primary ovarian fibrosarcomas are extremely rare neoplasms, and only 50 cases have been reported in the English literature. Diagnosis can be difficult because of this condition's rarity, and other similar appearing mesenchymal lesions should be ruled out. METHODS: A 50-year-old postmenopausal woman came to our hospital because of abdominopelvic pain. Ultrasonography revealed a 41x33 mm heterogeneous solid mass in the right ovary. Total blood counts, biochemical parameters, and tumor markers were within normal ranges...
July 2016: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/28469068/crystal-structure-and-photoluminescence-properties-of-a-new-monomeric-copper-ii-complex-bis-3-3-hydroxypropyl-imino-methyl-4-nitrophenolato-%C3%AE%C2%BA-3-o-n-o-copper-ii
#15
Cagdas Kocak, Gorkem Oylumluoglu, Adem Donmez, M Burak Coban, Ugur Erkarslan, Muhittin Aygun, Hulya Kara
Copper(II)-Schiff base complexes have attracted extensive interest due to their structural, electronic, magnetic and luminescence properties. The title novel monomeric Cu(II) complex, [Cu(C10H11N2O4)2], has been synthesized by the reaction of 3-{[(3-hydroxypropyl)imino]methyl}-4-nitrophenol (H2L) and copper(II) acetate monohydrate in methanol, and was characterized by elemental analysis, UV and IR spectroscopies, single-crystal X-ray diffraction analysis and a photoluminescence study. The Cu(II) atom is located on a centre of inversion and is coordinated by two imine N atoms, two phenoxy O atoms in a mutual trans disposition and two hydroxy O atoms in axial positions, forming an elongated octahedral geometry...
May 1, 2017: Acta Crystallographica. Section C, Structural Chemistry
https://www.readbyqxmd.com/read/28468181/saccular-aneurysm-of-internal-jugular-vein-in-a-young-patient
#16
Korhan Kilic, Ugur Kaya, Muhammed Sedat Sakat, Recai Mazlumoglu, Harun Ucuncu
No abstract text is available yet for this article.
May 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28467588/the-effect-of-2-different-surgical-methods-on-intracompartmental-pressure-value-in-tibial-shaft-fracture-an-experimental-study-in-a-rabbit-model
#17
Cemil Ertürk, Mehmet Akif Altay, Nuray Altay, İbrahim Avşin Öztürk, İslam Baykara, Cemil Sert, Uğur Erdem Işıkan
BACKGROUND: Intracompartmental pressure (ICP) monitoring is a widely used modality, particularly after intramedullary nailing of tibial shaft fractures. It was hypothesized that ICP value in fracture fixed with Ilizarov circular fixator (ICF) might be lower than in fracture fixed with intramedullary pin (IMP). The present study is a comparison of ICP value in tibial fractures in a rabbit model fixed with ICF and IMP. METHODS: Twenty male New Zealand White rabbits were randomly divided into 2 groups of equal size: ICF group (Group 1) and IMP group (Group 2)...
March 2017: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/28466830/an-unusual-mass-in-unusual-gender
#18
Yavuzer Koza, Uğur Kaya, Ziya Şimşek, Şule Karakelleoğlu
No abstract text is available yet for this article.
April 2017: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/28460367/a-retrospective-study-with-icast-r-ispcan-child-abuse-screening-tools-retrospective-questionnaire-for-determination-of-child-abuse-in-first-year-medical-students-in-turkish-population
#19
Erdem Simsek, Sevay Alsen Guney, Serpil Ugur Baysal
Child Abuse and Neglect (CAN) is an important problem both in Turkey and worldwide. Unfortunately, we still don't have enough and reliable data on this important subject. In this study, we aimed to investigate the prevalence of childhood maltreatment in a population of first year medical students in a Turkish university using the retrospective version of the ISPCAN Child Abuse Screening Tool (ICAST-R). One hundred seventy three first year medical students, aged between 18 and 24 years, who agreed to complete the ICAST-R questionnaire, were recruited in our study...
April 28, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28455392/biomarker-accessible-and-chemically-addressable-mechanistic-subtypes-of-braf-melanoma
#20
Banu Eskiocak, Elizabeth McMillan, Saurabh Mendiratta, Rahul Kollipara, Hailei Zhang, Caroline Humphries, Changguang Wang, Jose Garcia-Rodriguez, Ming Ding, Aubhishek Zaman, Tracy Rosales, Ugur Eskiocak, Michael P Smith, Jessica Sudderth, Kakajan Komurov, Ralph J DeBerardinis, Claudia Wellbrock, Michael A Davies, Jennifer A Wargo, Yonghao Yu, Jef K De Brabander, Noelle S Williams, Lynda Chin, Helen Rizos, Georgina V Long, Ralf Kittler, Michael White
Genomic diversity among melanoma tumors limits durable control with conventional and targeted therapies. Nevertheless, pathological activation of the ERK1/2 pathway is a linchpin tumorigenic mechanism associated with the majority of primary and recurrent disease. Therefore, we sought to identify therapeutic targets that are selectively required for tumorigenicity in the presence of pathological ERK1/2 signaling. By integration of multi-genome chemical and genetic screens; recurrent architectural variants in melanoma tumor genomes; and patient outcome data; we identified 2 mechanistic subtypes of BRAF(V600) melanoma that inform new cancer cell biology and offer new therapeutic opportunities...
April 28, 2017: Cancer Discovery
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