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Jigar C Chauhan, Nicholas B Slamon
OBJECTIVE: Advances in molecular diagnosis have led to increased testing for single and multiviral respiratory infection in routine clinical practice. This study compares outcomes between single and multiviral respiratory infections in children younger than 5 years old admitted to the PICU with respiratory failure. DESIGN: Retrospective, single-center, cohort study. SETTING: Tertiary-care, freestanding children's hospital. PATIENTS: Children younger than 5 years old admitted to the PICU with respiratory failure and positive respiratory molecular panel...
June 16, 2017: Pediatric Critical Care Medicine
Hyojin Ko, Leila F Deravi, Sung-Jin Park, Jingon Jang, Takhee Lee, Cheong Kang, Jin Seok Lee, Kevin Kit Parker, Kwanwoo Shin
Millimeter-long conducting fibers can be fabricated from carbon nanomaterials via a simple method involving the release of a prestrained protein layer. This study shows how a self-rolling process initiated by polymerization of a micropatterned layer of fibronectin (FN) results in the production of carbon nanomaterial-based microtubular fibers. The process begins with deposition of carbon nanotube (CNT) or graphene oxide (GO) particles on the FN layer. Before polymerization, particles are discrete and nonconducting, but after polymerization the carbon materials become entangled to form an interconnected conducting network clad by FN...
June 19, 2017: Advanced Materials
Yoones Kabiri, Adithya N Ananth, Jaco van der Torre, Allard Katan, Jin-Yong Hong, Sairam Malladi, Jing Kong, Henny Zandbergen, Cees Dekker
While graphene may appear to be the ultimate support membrane for transmission electron microscopy (TEM) imaging of DNA nanostructures, very little is known if it poses an advantage over conventional carbon supports in terms of resolution and contrast. Microscopic investigations are carried out on DNA origami nanoplates that are supported onto freestanding graphene, using advanced TEM techniques, including a new dark-field technique that is recently developed in our lab. TEM images of stained and unstained DNA origami are presented with high contrast on both graphene and amorphous carbon membranes...
June 16, 2017: Small
Michael P Koster, Jackson H Williams, Jacqueline Gautier, Renee Alce, Bernard E Trappey
Global health initiatives from academic medical centers have rapidly proliferated over the last decade. This paper endeavors to describe our 5-year experience as an academic medical collaborative supporting healthcare delivery, medical training, and research at Hôpital Saint Damien-Nos Petits Frères et Soeurs, the only freestanding children's hospital in Haiti. Descriptions of the history and current activities of our academic medical collaborative, its partnership and communication structure, its evolution to fill the expressed needs of our host site, its funding mechanisms, and its challenges and opportunities for the future are included...
2017: Frontiers in Public Health
Helmut Lutz, Vance Jaeger, Lars Schmüser, Mischa Bonn, Jim Pfaendtner, Tobias Weidner
The silaffin peptide R5 is instrumental to the mineralization of silica cell walls of diatom organisms. The peptide is also widely employed in biotechnology, for example, in the encapsulation of enzymes and for fusion proteins in tissue regeneration. Despite its scientific and technological importance, the interfacial structure of R5 during silica precipitation remains poorly understood. We herein elucidate the conformation of the peptide in its active form within silica sheets by interface-specific vibrational spectroscopy in combination with molecular dynamics simulations...
June 13, 2017: Angewandte Chemie
Christine M White, Joanna E Thomson, Angela M Statile, Katherine A Auger, Ndidi Unaka, Matthew Carroll, Karen Tucker, Derek Fletcher, David E Hall, Jeffrey M Simmons, Patrick W Brady
Children with medical complexity are a rapidly growing inpatient population with frequent, lengthy, and costly hospitalizations. During hospitalization, these patients require care coordination among multiple subspecialties and their outpatient medical homes. At a large freestanding children's hospital, a new inpatient model of care was developed in an effort to consistently provide coordinated, family-centered, and efficient care. In addition to expanding the multidisciplinary team to include a pharmacist, dietician, and social worker, the team redesign included: (1) medication reconciliation rounds, (2) care coordination rounds, and (3) multidisciplinary weekly handoff with outpatient providers...
June 8, 2017: Hospital Pediatrics
H Daoui, X Cai, F Boubenider, P Laugier, Q Grimal
The material properties of the trabeculae (tissue-level properties), together with the trabecular architecture and the bone volume fraction determine the apparent millimetre-scale bone mechanical properties. We present a novel method to measure trabecular tissue elastic modulus Et using resonant ultrasound spectroscopy (RUS). The first mechanical resonance frequency f(e) of a freestanding cuboid specimen is measured and used to back-calculate Et. The steps of the back-calculation are (1) the apparent stiffness tensors C(Et˜) is computed using micro-finite elements for a set of trial values of tissue Young's modulus Et˜ based on the computed tomography image of the specimen; (2) the modeled free-vibration resonance frequencies f(m)(Et˜) of the specimen is calculated with the Rayleigh-Ritz method using C(Et˜); (3) finally, Et is obtained by interpolation using f(e) and f(m)(Et˜)...
May 30, 2017: Journal of the Mechanical Behavior of Biomedical Materials
Jan W Kuhlmann, Meike Junius, Ulf Diederichsen, Claudia Steinem
In vitro single-vesicle fusion assays are important tools to analyze the details of SNARE-mediated fusion processes. In this study, we employed planar pore-spanning membranes (PSMs) prepared on porous silicon substrates with large pore diameters of 5 μm, allowing us to compare the process of vesicle docking and fusion on the supported parts of the PSMs (s-PSMs) with that on the freestanding membrane parts (f-PSM) under the exact same experimental conditions. The PSMs harbor the t-SNARE ΔN49-complex to investigate the dynamics and fusogenicity of single large unilamellar vesicles doped with the v-SNARE synaptobrevin 2 by means of spinning-disc confocal microscopy with a time resolution of 10 ms...
June 6, 2017: Biophysical Journal
Myungkoo Kang, Yu Yuwen, Wenchong Hu, Seokho Yun, Krishnamurthy Mahalingam, Bin Jiang, Kurt Eyink, Ekaterina Poutrina, Kathleen Richardson, Theresa S Mayer
One-dimensional Au nanoparticle arrays encapsulated within freestanding SiO2 nanowires are fabricated by thermal oxidation of Au-coated Si nanowires with controlled diameter and surface modulation. The nanoparticle diameter is determined by the Si nanowire diameter and Au film thickness, while the interparticle spacing is independently controlled by the Si nanowire modulation. The optical absorption of randomly oriented Au nanoparticle arrays exhibits a strong plasmonic response at 550 nm. Scanning transmission electron microscopy (STEM)-electron energy loss spectrum (EELS) of nanoparticle arrays confirmed the same plasmonic response and demonstrated uniform optical properties of the Au nanoparticles...
June 14, 2017: ACS Nano
James E Graham, Janet Prvu Bettger, Addie Middleton, Heidi Spratt, Gulshan Sharma, Kenneth J Ottenbacher
OBJECTIVE: To examine the effects of facility-level acute-postacute continuity on probability of community discharge and 30-day rehospitalization following inpatient rehabilitation. DATA SOURCES: We used national Medicare enrollment, claims, and assessment data to study 541,097 patients discharged from 1,156 inpatient rehabilitation facilities (IRFs) in 2010-2011. STUDY DESIGN: We calculated facility-level continuity as the percentages of an IRF's patients admitted from each contributing acute care hospital...
June 5, 2017: Health Services Research
Nadav Amdursky, Xuhua Wang, Paul Meredith, D Jason Riley, David J Payne, Donal D C Bradley, Molly M Stevens
Exploring long-range electron transport across protein assemblies is a central interest in both the fundamental research of biological processes and the emerging field of bioelectronics. This work examines the use of serum-albumin-based freestanding mats as macroscopic electron mediators in bioelectronic devices. In particular, this study focuses on how doping the protein mat with hemin improves charge-transport. It is demonstrated that doping can increase conductivity 40-fold via electron hopping between adjacent hemin molecules, resulting in the highest measured conductance for a protein-based material yet reported, and transport over centimeter length scales...
May 31, 2017: Advanced Materials
Juan Camilo Alvarez Quiceno, G R Schleder, E Marinho, A Fazzio
We perform an \textit{ab initio} study of the electronic structure and magnetic properties of $3d$, $4d$ and $5d$ transition metals (TM) adsorbed on freestanding and Ag(111)--supported $\beta_{12}$--borophene. The stability of TM adsorption is high for all atoms and increases with the period. For the $3d$ TM adsorption we observe strong exchange effects. The Ag(111)--surface show a small effect on results. Studying the magnetic interaction between TMs, VIB atoms show direct exchange, while VIIB and Fe show 2p(B)--mediated indirect exchange...
May 31, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
Wen-Cai Yi, Wei Liu, Jorge Botana, Lei Zhao, Zhen Liu, Jing-Yao Liu, Mao-Sheng Miao
We propose a series of planar boron allotropes with honeycomb topology and demonstrate that their band structures exhibit Dirac cones at the K point, the same as graphene. In particular, the Dirac point of one honeycomb boron sheet locates precisely on the Fermi level, rendering it as a topologically equivalent material to graphene. Its Fermi velocity (vf) is 6.05 × 10(5) m/s, close to that of graphene. Although the freestanding honeycomb B allotropes are higher in energy than α-sheet, our calculations show that a metal substrate can greatly stabilize these new allotropes...
June 15, 2017: Journal of Physical Chemistry Letters
Angelo Accardo, Marie-Charline Blatché, Rémi Courson, Isabelle Loubinoux, Christophe Thibault, Laurent Malaquin, Christophe Vieu
The realization of 3D architectures for the study of cell growth, proliferation, and differentiation is a task of fundamental importance for both technological and biological communities involved in the development of biomimetic cell culture environments. Here we report the fabrication of 3D freestanding scaffolds, realized by multiphoton direct laser writing and seeded with neuroblastoma cells, and their multitechnique characterization using advanced 3D fluorescence imaging approaches. The high accuracy of the fabrication process (≈200 nm) allows a much finer control of the micro- and nanoscale features compared to other 3D printing technologies based on fused deposition modeling, inkjet printing, selective laser sintering, or polyjet technology...
May 30, 2017: Small
Sofia Chaudhary, Wendy J Pomerantz, Beverly Miller, Anqi Pan, Maneesha Agarwal
BACKGROUND: Injury is the leading cause of death in children. Although many pediatric hospitals and trauma centers provide injury prevention (IP) programming, there is no national standard. This study aims to identify characteristics of a sustainable and successful IP program by querying programs affiliated with the Injury Free Coalition for Kids (IFCK). METHODS: IFCK sites were sent a 30-question survey via e-mail. Questions focused on demographics, scope of IP activities, self-efficacy, and outcome measures including: finances, academic productivity, and legislative advocacy...
May 25, 2017: Journal of Trauma and Acute Care Surgery
Chuantao Zhu, Peng Liu, Aji P Mathew
Nanocellulose, graphene oxide (GO), and their combinations there off have attracted great attention for the application of water purification recently because of their unique adsorption capacity, mechanical characteristics, coordination with transition metal ions, surface charge density, and so on. In the current study, (2,2,6,6-tetramethylpiperidine-1-oxylradical) (TEMPO)-mediated oxidized cellulose nanofibers (TOCNF) and GO sheets or graphene oxide nanocolloid (nanoGO) biohybrids were prepared by vacuum filtration method to obtain self-assembled adsorbents and membranes for water purification...
June 21, 2017: ACS Applied Materials & Interfaces
Johnny Kao, Amanda Zucker, Elizabeth A Mauer, Andrew T Wong, Paul Christos, Josephine Kang
INTRODUCTION: In recent years, major changes in health care policy have affected oncology practice dramatically. In this context, we examined the effect of practice structure on volume and payments for radiation oncology services using the 2013 Medicare Provider Utilization and Payment Data: Physician and Other Supplier Public Use File (POSPUF) for New York State radiation oncologists. METHODS: The Medicare POSPUF data was queried, and individual physicians were classified into freestanding office-based and hospital-based practices...
April 25, 2017: Curēus
Adam L Hersh, Jared Olson, Chris Stockmann, Emily A Thorell, Elizabeth D Knackstedt, Lawanda Esquibel, Susan Sanderson, Andrew T Pavia
We developed an outpatient parenteral antibiotic therapy (OPAT) stewardship program in a freestanding children's hospital to improve the appropriateness of OPAT prescribing. Introduction of the program enabled expert review of nearly 90% of the patients being prepared for discharge with OPAT and was associated with a 24% reduction in OPAT use.
May 26, 2017: Journal of the Pediatric Infectious Diseases Society
Rachel Root, Paul Krogh, Kristi Gullickson, Barbara Hintzen, Martha Christophersen, Steven Kastendieck, Matt Kresl
No abstract text is available yet for this article.
June 1, 2017: American Journal of Health-system Pharmacy: AJHP
Atul Vats, Clara Hopkins, Kelly M Hatfield, Jia Yan, Robert Palmer, Pinar Keskinocak
OBJECTIVE: As a result of a workshop to identify common causes of unplanned extubation, Children's Healthcare of Atlanta developed a scoring tool (Risk Assessment Score) to stratify patients into groups of low, moderate, high, and extreme risk. This tool could be used to institute appropriate monitoring or interventions for patients with high risks of unplanned extubation to enhance safety. The objective of this study is to test the hypothesis that the Risk Assessment Score will correlate with the occurrence rate of unplanned extubation in pediatric patients...
May 20, 2017: Pediatric Critical Care Medicine
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