Shunqin Chen, Han Yang, Shan Zhang, Faze Zhu, Shan Liu, Huan Gao, Qing Diao, Wenbo Ding, Yuemeng Chen, Peng Luo, Yubo Liu
This study developed an online solid-phase extraction ultra-high performance liquid chromatography-tandem mass spectrometry (Online-SPE-UHPLC-MS/MS) method for the analysis of 28 illegal drugs in sewage. To achieve this, 28 isotope internal standards (ISTDs) were added to 3 mL sewage samples, the pH was adjusted to 7-8 using hydrochloric acid or 20% ammonia water, followed by centrifugation, filtration, and analysis using UHPLC-MS/MS. The results indicated an excellent linearity of 1-300 ng L-1 , and cotinine in the concentration range of 20-6000 ng L-1 , linear correlation coefficient R2 > 0...
March 30, 2024: Heliyon