keyword
https://read.qxmd.com/read/38524560/effects-of-a-novel-bacillus-subtilis-gxyx-crude-lipopeptide-against-salmonella-enterica-serovar-typhimurium-infection-in-mice
#21
JOURNAL ARTICLE
Jingya Zhang, Yifan Wu, Wei Li, Honglin Xie, Jingyan Li, Yongqiang Miao, Zengqi Yang, Yefei Zhou, Xinglong Wang
The increased rate of antibiotic resistance strongly limits the resolution of Salmonella enterica serovar Typhimurium (S. Typhimurium) infection. Therefore, new strategies to control bacterial infections are urgently needed. Bacillus subtilis (B. subtilis) and its metabolites are desirable antibacterial agents. Here, we aimed to evaluate the antibacterial activity of the novel B. subtilis strain GXYX (No: PRJNA940956) crude lipopeptide against S . Typhimurium. In vitro, GXYX crude lipopeptides affected S . Typhimurium biofilm formation and swimming and attenuated the adhesion and invasion abilities of S ...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38522491/surface-modification-of-hollow-gold-nanoparticles-conducted-by-incorporating-cancer-cell-membrane-and-as1411-aptamer-aiming-to-achieve-a-dual-targeted-therapy-for-colorectal-cancer
#22
JOURNAL ARTICLE
Sepideh Hassibian, Seyed Mohammad Taghdisi, Zahra Jamshidi, Ali Samie, Morteza Alinezhad Nameghi, Mersedeh Shayan, Naser Farrokhi, Mona Alibolandi, Mohammad Ramezani, Seyed Mohsen Dehnavi, Khalil Abnous
Due to its inherent membrane structure, a nanostructure enveloped by an active cell membrane possesses distinctive characteristics such as prolonged presence in the bloodstream, precise identification capabilities, and evasion of immune responses. This research involved the production of biomimetic nanoparticles, specifically hollow gold nanoparticles (HGNPs) loaded with methotrexate (MTX), which were further coated with cancer cell membrane. These nanoparticles were then adorned with AS1411 aptamer to serve as a targeting agent (Apt-CCM-HG@MTX)...
March 22, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38522283/interfacial-blending-in-co-axially-electrospun-polymer-core-shell-fibers-and-their-interaction-with-cells-via-focal-adhesion-point-analysis
#23
JOURNAL ARTICLE
Martyna Polak, Daniel P Ura, Krzysztof Berniak, Piotr K Szewczyk, Mateusz M Marzec, Urszula Stachewicz
Electrospun polymer scaffolds have gained prominence in biomedical applications, including tissue engineering, drug delivery, and wound dressings, due to their customizable properties. As the interplay between cells and materials assumes fundamental significance in biomaterials research, understanding the relationship between fiber properties and cell behaviour is imperative. Nevertheless, altering fiber properties introduces complexity by intertwining mechanical and surface chemistry effects, challenging the differentiation of their individual impacts on cell behaviour...
March 20, 2024: Colloids and Surfaces. B, Biointerfaces
https://read.qxmd.com/read/38521924/an-in-vitro-study-elucidating-the-synergistic-effects-of-aqueous-cinnamon-extract-and-an-anti-tnf-%C3%AE-biotherapeutic-implications-for-a-complementary-and-alternative-therapy-for-non-responders
#24
JOURNAL ARTICLE
Shubrata Khedkar, Minhaj Ahmad Khan
BACKGROUND: Tumor necrosis factor-alpha (TNF-α) is a critical pro-inflammatory cytokine, and its abnormal production is associated with several immune mediated inflammatory diseases (IMID). Biological anti-TNF-α therapy includes treatment with monoclonal antibodies such as infliximab which have proven successful and are well-tolerated in most patients. Unfortunately, some patients may not respond to therapy (primary non-responders) or may lose sensitivity to the biological agent over time (early and late secondary non-responders)...
March 23, 2024: BMC complementary medicine and therapies
https://read.qxmd.com/read/38520952/inhibition-of-platelet-adhesion-to-exposed-subendothelial-collagen-by-steric-hindrance-with-blocking-peptide-nanoparticles
#25
JOURNAL ARTICLE
Anqi Wang, Kai Yue, Xiaotong Yan, Weishen Zhong, Genpei Zhang, Lei Wang, Hua Zhang, Xinxin Zhang
The inhibition of platelet adhesion to collagen in exposed vessels represents an innovative approach to the treatment of atherosclerosis and thrombosis. This study aimed to engineer peptide-based nanoparticles that prevent platelet binding to subendothelial collagen by engaging with collagen with high affinity. We examined the interactions between integrin α2/ glycoprotein VI/ von Willebrand factor A3 domain and collagen, as well as between the synthesized peptide nanoparticles and collagen, utilizing molecular dynamics simulations and empirical assays...
March 20, 2024: Colloids and Surfaces. B, Biointerfaces
https://read.qxmd.com/read/38518590/plant-mucus-derived-microgels-blood-triggered-gelation-and-strong-hemostatic-adhesion
#26
JOURNAL ARTICLE
Yu Huang, Weichao Hu, Kaige Xu, Ruijue Dan, Shali Tan, Zhenzhen Shu, Xin Li, Hangzong Liu, Chaoqiang Fan, Malcolm Xing, Shiming Yang
Arrest of bleeding usually applies clotting agents to trigger coagulation procedures or adhesives to interrupt blood flow through sealing the vessel; however, the efficiency is compromised. Here, we propose a concept of integration of hemostasis and adhesion via yam mucus's microgels. The mucus microgels exhibit attractive attributes of hydrogel with uniform size and shape. Their shear-thinning, self-healing and strong adhesion make them feasible as injectable bioadhesion. Exceptionally, the blood can trigger the microgels' gelation with the outcome of super extensibility, which leads to the microgels a strong hemostatic agent...
March 16, 2024: Biomaterials
https://read.qxmd.com/read/38518390/improved-hydration-property-of-tissue-adhesive-hemostatic-microparticle-based-on-hydrophobically-modified-alaska-pollock-gelatin
#27
JOURNAL ARTICLE
Shima Ito, Kazuhiro Nagasaka, Hiyori Komatsu, Debabrata Palai, Akihiro Nishiguchi, Tetsushi Taguchi
The management of bleeding is an important aspect of endoscopic surgery to avoid excessive blood loss and minimize pain. In clinical settings, sprayable hemostatic particles are used for their easy delivery, adaptability to irregular shapes, and rapid hydration. However, conventional hemostatic particles present challenges associated with tissue adhesion. In a previous study, we reported tissue adhesive microparticles (C10-sa-MPs) derived from Alaska pollock gelatin modified with decyl groups (C10-sa-ApGltn) using secondary amines as linkages...
March 19, 2024: Biomater Adv
https://read.qxmd.com/read/38518106/an-oral-carbon-monoxide-releasing-molecule-protects-against-acute-hyper-hemolysis-in-sickle-cell-disease
#28
JOURNAL ARTICLE
Kim Anh Nguyen, Alessandro Matte, Roberta Foresti, Enrica Federti, Laurent Kiger, Cecile Lefebvre, Hakim Hocini, Yanis Pelinski, Hiroaki Kitagishi, Laura Bencheikh, France Pirenne, Lucia De Franceschi, Roberto Motterlini, Pablo Bartolucci
Acute hyper-hemolysis is a severe life-threatening complication in patients with sickle cell disease (SCD) that may occur during delayed hemolytic transfusion reaction (DHTR), or vaso-occlusive crises associated with multi-organ failure. Here, we developed in vitro and in vivo animal models to mimic endothelial damage during the early phase of hyper-hemolysis in SCD. We then used the carbon monoxide (CO)-releasing molecule CORM-401 and examined its effects against endothelial activation, damage, and inflammation inflicted by hemolysates containing red blood cell membrane-derived particles...
March 22, 2024: Blood
https://read.qxmd.com/read/38517070/color-change-of-laminate-veneer-restorations-applied-to-bleached-teeth
#29
JOURNAL ARTICLE
Buse Atak Ay, Sebnem Begum Turker
OBJECTIVE: The aim of this study was to examine the color stability of laminate veneer restorations restored with CAD/CAM material applied to bleached teeth. MATERIAL AND METHODS: In this study, 80 upper central teeth extracted because of periodontal, orthodontic or trauma problems were used. The teeth were embedded in acrylic blocks and divided into 8 groups (n=10). Groups A, B, C and D were bleached with vital bleaching agent before preparation, and teeth were prepared for laminate veneer restorations...
March 22, 2024: International Journal of Computerized Dentistry
https://read.qxmd.com/read/38515837/baicalin-administration-could-rescue-high-glucose-induced-craniofacial-skeleton-malformation-by-regulating-neural-crest-development
#30
JOURNAL ARTICLE
Jia-Qi Lu, Zhi-Yan Luo, Chengyang Sun, Si-Miao Wang, Dixiang Sun, Ruo-Jing Huang, Xuesong Yang, Yong Ding, Guang Wang
Hyperglycemia in pregnancy can increase the risk of congenital disorders, but little is known about craniofacial skeleton malformation and its corresponding medication. Our study first used meta-analysis to review the previous findings. Second, baicalin, an antioxidant, was chosen to counteract high glucose-induced craniofacial skeleton malformation. Its effectiveness was then tested by exposing chicken embryos to a combination of high glucose (HG, 50 mM) and 6 μM baicalin. Third, whole-mount immunofluorescence staining and in situ hybridization revealed that baicalin administration could reverse HG-inhibited neural crest cells (NCC) delamination and migration through upregulating the expression of Pax7 and Foxd3, and mitigate the disordered epithelial-mesenchymal transition (EMT) process by regulating corresponding adhesion molecules and transcription factors (i...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38513299/promoting-effect-of-phosvitin-in-the-mineralization-of-eggshell-inner-membrane-with-the-application-in-osteogenic-induction-scaffold
#31
JOURNAL ARTICLE
Wei Liu, Qiancheng Zhao, Cuie Tang, Zhaoxia Cai, Yongguo Jin, Dong Uk Ahn, Xi Huang
Exploring affordable and easily prepared inorganic-organic hybrid membrane materials has attracted a great interest in the bone repair field. This study is based on biomimetic mineralization technique to study the role of phosvitin (PV) in the mineralized process of eggshell inner membrane. Results showed that PV promoted the formation of hydroxyapatite on the eggshell inner membrane surface, and the phosvitin content in the simulated body fluid was decreased during the mineralization process. Besides, in vitro preosteoblast experiments indicated that mineralized membrane with PV exhibited more conducive to cell proliferation and differentiation than that mineralized membrane without PV...
March 11, 2024: Colloids and Surfaces. B, Biointerfaces
https://read.qxmd.com/read/38512224/polymerized-and-colloidal-ionic-liquids%C3%A2-syntheses-and-applications
#32
REVIEW
Qi Li, Feng Yan, John Texter
The breadth and importance of polymerized ionic liquids (PILs) are steadily expanding, and this review updates advances and trends in syntheses, properties, and applications over the past five to six years. We begin with an historical overview of the genesis and growth of the PIL field as a subset of materials science. The genesis of ionic liquids (ILs) over nano to meso length-scales exhibiting 0D, 1D, 2D, and 3D topologies defines colloidal ionic liquids, CILs, which compose a subclass of PILs and provide a synthetic bridge between IL monomers (ILMs) and micro to macro-scale PIL materials...
March 21, 2024: Chemical Reviews
https://read.qxmd.com/read/38510964/evaluation-of-novel-compounds-as-anti-bacterial-or-anti-virulence-agents
#33
REVIEW
Brankica Filipić, Dušan Ušjak, Martina Hrast Rambaher, Slavica Oljacic, Marina T Milenković
Antimicrobial resistance is a global threat, leading to an alarming increase in the prevalence of bacterial infections that can no longer be treated with available antibiotics. The World Health Organization estimates that by 2050 up to 10 million deaths per year could be associated with antimicrobial resistance, which would equal the annual number of cancer deaths worldwide. To overcome this emerging crisis, novel anti-bacterial compounds are urgently needed. There are two possible approaches in the fight against bacterial infections: a) targeting structures within bacterial cells, similar to existing antibiotics; and/or b) targeting virulence factors rather than bacterial growth...
2024: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/38509781/adhesion-and-sealing-of-different-universal-adhesive-systems-associated-with-bulk-fill-resins-after-using-endodontic-irrigation-solutions-an-in%C3%A2-vitro-study
#34
JOURNAL ARTICLE
Érika Mayumi Omoto, Anderson Catelan, Paulo Henrique Dos Santos, Luciano Tavares Angelo Cintra, Fernanda de Souza E Silva Ramos, Caio César Pavani, André Luiz Fraga Briso, Ticiane Cestari Fagundes
This study aimed to evaluate the interface of universal adhesive (UA) with bulk-fill resin (BF) and dentin, after endodontic irrigation. The pulp chamber of 96 molars was irrigated with chlorhexidine 2% (CHX) or sodium hypochlorite 5.25% (NaOCl) and restored according to three restorative protocols. Microtensile bond strength (μTBS) and nanoleakage tests were performed after 24 h of thermocycling. Kruskal Wallis, Mann-Whitney and Wilcoxon were performed (p < 0.05). Comparing restorative systems, a difference was found only when irrigated with CHX after 24 h...
March 21, 2024: Australian Endodontic Journal: the Journal of the Australian Society of Endodontology Inc
https://read.qxmd.com/read/38507032/search-for-influence-factors-in-lactobacilli-with-probiotic-properties-isolated-from-traditional-kazakh-foods
#35
JOURNAL ARTICLE
Arman Abilkhadirov, Akbota Satenova, Maira Urazova, Altynai Tuyakova, Serik Shaikhin
The aim of this study was to investigate the factors influencing the probiotic potential of lactobacilli isolated from traditional Kazakh foods, focusing on the identification and characterisation of multifunctional proteins. The basis of the methodological approach in this scientific study is an empirical, experimental study of the factors of influence produced by lactobacilli, which were obtained from traditional Kazakh foods and have pronounced probiotic properties. In this scientific work, results were obtained indicating that the expressed factors of probiotic action can perform adhesive and signalling functions by analogy with homologous proteins of pathogenic and commensal/probiotic bacteria...
March 20, 2024: Probiotics and Antimicrobial Proteins
https://read.qxmd.com/read/38504299/lipoteichoic-acids-influence-cell-shape-and-bacterial-division-of-streptococcus-suis-serotype-2-but-play-a-limited-role-in-the-pathogenesis-of-the-infection
#36
JOURNAL ARTICLE
Servane Payen, Marie-Christine Giroux, Nicolas Gisch, Ursula Schombel, Nahuel Fittipaldi, Mariela Segura, Marcelo Gottschalk
Streptococcus suis serotype 2 is a major swine pathogen and a zoonotic agent, causing meningitis in both swine and humans, responsible for substantial economic losses to the swine industry worldwide. The pathogenesis of infection and the role of bacterial cell wall components in virulence have not been fully elucidated. Lipoproteins, peptidoglycan, as well as lipoteichoic acids (LTA) have all been proposed to contribute to virulence. In the present study, the role of the LTA in the pathogenesis of the infection was evaluated through the characterisation of a mutant of the S...
March 19, 2024: Veterinary Research
https://read.qxmd.com/read/38504287/characterisation-and-evaluation-of-physical-properties-of-ah-plus-sealer-with-and-without-the-incorporation-of-petasin-pachymic-acid-curcumin-and-shilajit-an-invitro-study
#37
JOURNAL ARTICLE
Selvanathan Mj Vinola, Sekar Mahalaxmi
BACKGROUND: AH Plus, an epoxy resin-based sealer, is widely used in endodontic practice, owing to its good physical properties that confers longstanding dimensional stability and good adhesion to dentin. Nevertheless, its propensity to trigger inflammation, especially in its freshly mixed state, has been extensively documented. Phytochemicals such as Petasin, Pachymic acid, Curcumin, and Shilajit are known for their anti-inflammatory and analgesic effects. This study aimed to analyze and determine the effect of these natural products on the physical properties of AH Plus sealer when incorporated with the sealer...
March 19, 2024: BMC Oral Health
https://read.qxmd.com/read/38503078/bioinspired-superhydrophobic-surfaces-with-silver-and-nitric-oxide-releasing-capabilities-to-prevent-device-associated-infections-and-thrombosis
#38
JOURNAL ARTICLE
Ekrem Ozkan, Lori M Estes Bright, Anil Kumar, Rashmi Pandey, Ryan Devine, Divine Francis, Sama Ghalei, Morgan Ashcraft, Patrick Maffe, Megan Brooks, Arpita Shome, Mark Garren, Hitesh Handa
Bacteria-associated infections and thrombus formation are the two major complications plaguing the application of blood-contacting medical devices. Therefore, functionalized surfaces and drug delivery for passive and active antifouling strategies have been employed. Herein, we report the novel integration of bio-inspired superhydrophobicity with nitric oxide release to obtain a functional polymeric material with anti-thrombogenic and antimicrobial characteristics. The nitric oxide release acts as an antimicrobial agent and platelet inhibitor, while the superhydrophobic components prevent non-specific biofouling...
March 15, 2024: Journal of Colloid and Interface Science
https://read.qxmd.com/read/38502975/nanographene-au-fine-tuning-to-intensify-plasmonic-resonance-of-polymeric-hybrid-bionanosystem-for-synergistic-phototherapy-and-nerve-photobiomodulation
#39
JOURNAL ARTICLE
Richa Jaswal, Dinesh Kumar, Abdelrahman I Rezk, Vignesh Krishnamoorthi Kaliannagounder, Chan Hee Park, Kyung Hyun Min
Here, we report the multi-photo-bioactivity of the plasmonic-nano graphitic coordinated polycaprolactone-based aligned nanofibrous scaffolds-based bionanosystem for photothermal breast and colon cancer therapies and peripheral nerve photobiomodulation. The size-optimized colloidal reduced graphene oxide (nRGO, 180 nm) nanosheets, for enhanced photothermal impact, were surface-functionalized with gold nanospheres (AuNPs) to prepare the nRGO@AuNP monodispersed nano-composite and then doped 2.0 mg of nRGO@AuNP in biocompatible and biodegradable polymer polycaprolactone (PCL) to fabricate the nRGO@AuNP-PCL (2...
February 22, 2024: Colloids and Surfaces. B, Biointerfaces
https://read.qxmd.com/read/38502112/characterization-of-a-unique-attachment-organelle-single-cell-force-spectroscopy-of-giardia-duodenalis-trophozoites
#40
JOURNAL ARTICLE
Gubesh Gunaratnam, Ricarda Leisering, Ben Wieland, Johanna Dudek, Nicolai Miosge, Sören L Becker, Markus Bischoff, Scott C Dawson, Matthias Hannig, Karin Jacobs, Christian Klotz, Toni Aebischer, Philipp Jung
The unicellular parasite Giardia duodenalis is the causative agent of giardiasis, a gastrointestinal disease with global spread. In its trophozoite form, G. duodenalis can adhere to the human intestinal epithelium and a variety of other, artificial surfaces. Its attachment is facilitated by a unique microtubule-based attachment organelle, the so-called ventral disc. The mechanical function of the ventral disc, however, is still debated. Earlier studies postulated that a dynamic negative pressure under the ventral disc, generated by persistently beating flagella, mediates the attachment...
March 19, 2024: Nanoscale
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