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https://www.readbyqxmd.com/read/28088038/evidence-of-functional-duplicity-of-nestin-expression-in-the-adult-mouse-midbrain
#1
Parisa Farzanehfar, Shi Sheng Lu, Anupa Dey, Dharshani Musiienko, Hamzah Baagil, Malcolm K Horne, Tim D Aumann
Whether or not neurogenesis occurs in the adult substantia nigra pars compacta (SNc) is an important question relevant for developing better treatments for the motor symptoms of Parkinson's disease (PD). Although controversial, it is generally believed that dividing cells here remain undifferentiated or differentiate into glia, not neurons. However, there is a suggestion that Nestin-expressing neural precursor cells (NPCs) in the adult SNc have a propensity to differentiate into neurons, which we sought to confirm in the present study...
January 5, 2017: Stem Cell Research
https://www.readbyqxmd.com/read/28088003/the-effect-of-the-antioxidant-on-the-properties-of-thiolated-poly-aspartic-acid-polymers-in-aqueous-ocular-formulations
#2
Mária Budai-Szűcs, Gabriella Horvát, Benjámin Gyarmati, Barnabás Áron Szilágyi, András Szilágyi, Szilvia Berkó, Rita Ambrus, Piroska Szabó-Révész, Giuseppina Sandri, Maria Cristina Bonferoni, Carla Caramella, Erzsébet Csányi
Thiolated polymers are a promising new group of excipients, but their stability against atmospheric oxidation has not been investigated in detail, and only a few efforts have been made to improve their stability. The oxidation of the thiol groups in solutions of thiolated polymers may result in a decrease of mucoadhesion and unpredictable in situ gelation. The aims of our work were to study the stability of aqueous solutions of thiolated polymers and the effects of stabilizing agents. We investigated thiolated poly(aspartic acid) polymers stabilized with dithiothreitol, glutathione or acetylcysteine...
January 11, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28079144/igf-ir-cooperates-with-er%C3%AE-to-inhibit-breast-cancer-cell-aggressiveness-by-regulating-the-expression-and-localisation-of-ecm-molecules
#3
Nikolaos A Afratis, Panagiotis Bouris, Spyros S Skandalis, Hinke A Multhaupt, John R Couchman, Achilleas D Theocharis, Nikos K Karamanos
IGF-IR is highly associated with the behaviour of breast cancer cells. In ERα-positive breast cancer, IGF-IR is present at high levels. In clinical practice, prolonged treatment with anti-estrogen agents results in resistance to the therapy with activation of alternative signaling pathways. Receptor Tyrosine Kinases, and especially IGF-IR, have crucial roles in these processes. Here, we report a nodal role of IGF-IR in the regulation of ERα-positive breast cancer cell aggressiveness and the regulation of expression levels of several extracellular matrix molecules...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28079009/emerging-roles-of-calreticulin-in-cancer-implications-for-therapy
#4
Kavya Venkateswaran, Amit Verma, Anant Narayan Bhatt, Anju Shrivastava, Kailash Manda, Hanumantharao G Raj, Ashok Prasad, Christophe Len, Virinder S Parmar, Bilikere Dwarakanath
Calreticulin (CRT), initially identified as a ubiquitous calcium-binding protein in the endoplasmic reticulum, has emerged as a multifunctional protein with roles in calcium homeostasis, molecular chaperoning and cell adhesion. Emerging evidence suggests its involvement in tumorigenesis facilitating proliferation, migration, and adhesion. CRT translocated to the cell surface (ecto-CRT) serves as a phagocytic signal for immunogenic cell death (ICD) mediated through dendritic cells (DCs) and cytotoxic T-cell activation thereby making tumors susceptible to immunotherapy-based anti-cancer strategies...
January 11, 2017: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/28075462/dnalk2-inhibits-the-proliferation-and-invasiveness-of-breast-cancer-mda-mb-231-cells-through-the-smad-dependent-pathway
#5
Ke Wang, Xiaoxiao Sun, Hong Lei Feng, Chang Fei, Yan Zhang
Breast cancer is one of the most common malignant neoplasms diagnosed in females worldwide. Bone morphogenetic proteins (BMPs), which belong to the TGF-β superfamily, regulate a wide range of cellular responses including cell proliferation, differentiation, adhesion, migration and apoptosis in breast cancer. BMPs can bind to type I and II serine/threonine kinase receptors to regulate cell proliferation, invasion, migration, and apoptosis. Type I receptors are expressed in various breast cancer cell lines and primary tumor samples...
December 30, 2016: Oncology Reports
https://www.readbyqxmd.com/read/28075447/anti-metastatic-effect-of-rhodomyrtone-from-rhodomyrtus-tomentosa-on-human-skin-cancer-cells
#6
Malatee Tayeh, Sirinun Nilwarangoon, Wilawan Mahabusarakum, Ramida Watanapokasin
This study focused on the inhibitory effect of rhodomyrtone, a bioactive compound isolated from the leaves of Rhodomyrtus tomentosa (Aiton) Hassk., on cancer metastasis in epidermoid carcinoma A431 cells and on the verification of the underlying related molecular mechanisms of this event. We demonstrated that rhodomyrtone at the subcytotoxic concentration (0.5 and 1.5 µg/ml) exhibited pronounced inhibition of cancer metastasis by reducing cell migration, cell adhesive ability and cell invasion of A431 cells in a dose-dependent manner...
January 9, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28073846/extended-treatment-with-single-agent-ibrutinib-at-the-420-mg-dose-leads-to-durable-responses-in-chronic-lymphocytic-leukemia-small-lymphocytic-lymphoma
#7
Steven E Coutré, Richard R Furman, Ian W Flinn, Jan A Burger, Kristie Blum, Jeff Sharman, Jeffrey Jones, William Wierda, Weiqiang Zhao, Nyla A Heerema, Amy J Johnson, Anh Tran, Cathy Zhou, Elizabeth Bilotti, Danelle F James, John C Byrd, Susan O'Brien
PURPOSE: Ibrutinib, a first-in-class, once-daily, oral inhibitor of Bruton tyrosine kinase, promotes apoptosis, and inhibits B-cell proliferation, adhesion, and migration. Ibrutinib has demonstrated single-agent efficacy and acceptable tolerability at doses of 420 and 840 mg in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) who were treatment-naïve (TN) or had relapsed/refractory (R/R) CLL after ≥1 prior therapy in a phase Ib/II study (PCYC-1102). Subsequently, the ibrutinib 420 mg dose was approved in CLL...
January 10, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28070702/effects-of-tributylborane-activated-adhesive-and-two-silane-agents-on-bonding-computer-aided-design-and-manufacturing-cad-cam-resin-composite
#8
Ayano Shinohara, Yohsuke Taira, Takashi Sawase
The present study was conducted to evaluate the effects of an experimental adhesive agent [methyl methacrylate-tributylborane liquid (MT)] and two adhesive agents containing silane on the bonding between a resin composite block of a computer-aided design and manufacturing (CAD/CAM) system and a light-curing resin composite veneering material. The surfaces of CAD/CAM resin composite specimens were ground with silicon-carbide paper, treated with phosphoric acid, and then primed with either one of the two silane agents [Scotchbond Universal Adhesive (SC) and GC Ceramic Primer II (GC)], no adhesive control (Cont), or one of three combinations (MT/SC, MT/GC, and MT/Cont)...
January 9, 2017: Odontology
https://www.readbyqxmd.com/read/28068967/enterolactone-alters-fak-src-signaling-and-suppresses-migration-and-invasion-of-lung-cancer-cell-lines
#9
Shireen Chikara, Kaitlin Lindsey, Pawel Borowicz, Melpo Christofidou-Solomidou, Katie M Reindl
BACKGROUND: Systemic toxicity of chemotherapeutic agents and the challenges associated with targeting metastatic tumors are limiting factors for current lung cancer therapeutic approaches. To address these issues, plant-derived bioactive components have been investigated for their anti-cancer properties because many of these agents are non-toxic to healthy tissues. Enterolactone (EL) is a flaxseed-derived mammalian lignan that has demonstrated anti-migratory properties for various cancers, but EL has not been investigated in the context of lung cancer, and its anticancer mechanisms are ill-defined...
January 9, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28056742/fungal-biofilm-a-real-obstacle-against-an-efficient-therapy-lessons-from-candida
#10
Thaís Pereira de Mello, Lívia de Souza Ramos, Lys Adriana Braga-Silva, Marta Helena Branquinha, André Luis Souza Dos Santos
The past decades have witnessed a dramatic increase in invasive fungal infections, especially caused by different species belonging to the Candida genus. Nowadays, even after many improvements in several medical procedures, Candida infections (candidiasis) still account for an unacceptable high rate of morbimortality in hospital settings. Corroborating this statement, fungal biofilms formed on both abiotic and living surfaces are responsible for an important medical and economic burden, since biofilm lifestyle confers numerous advantages to the pathogens, including high tolerance to environmental stresses such as antimicrobials and host immune responses...
January 5, 2017: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/28056438/antibacterial-and-anti-biofilm-efficacy-of-fluoropolymer-coating-by-a-2-3-5-6-tetrafluoro-p-phenylenedimethanol-structure
#11
Qian Bao, Norihito Nishimura, Hirotoshi Kamata, Kentaro Furue, Yuki Ono, Masaaki Hosomi, Akihiko Terada
Fluorinated polymers generally function as antibacterial agents, but their anti-biofilm effect remains unresolved. This study investigates the efficacy of fluoropolymers containing 2,3,5,6-tetrafluoro-p-phenylenedimethanol (TFPDM) in preventing biofilm formation by Bacillus subtilis and Escherichia coli (Gram-positive and Gram-negative bacterial species). To this end, TFPDM-based acrylate and epoxy polymers (AF and EF, respectively) and their structural analogues without TFPDM (A and E, respectively) were synthesized...
December 15, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28053698/vincristine-alleviates-adriamycin-induced-nephropathy-through-stabilizing-actin-cytoskeleton
#12
Lei Yin, Youying Mao, Hejie Song, Ye Wang, Wei Zhou, Zhen Zhang
Antimicrotubule agent vincristine (VCR) has long been known as an alternative treatment for frequent relapse nephrotic syndrome and steroid-dependent nephrotic syndrome (SDNS). However, the mechanism is unknown. Here we found that VCR at a dosage much lower than that as an antimicrotubule agent can alleviate adriamycin (ADR)-induced proteinuria and podocyte foot process effacement. In cultured podocytes, VCR prevents ADR-induced actin fiber disorganization. In both in vitro and in vivo models, VCR suppresses ADR-induced overexpression of α3β1 integrin and focal adhesion kinase (FAK)...
2017: Cell & Bioscience
https://www.readbyqxmd.com/read/28053625/lipid-raft-integrity-is-required-for-survival-of-triple-negative-breast-cancer-cells
#13
Anil Badana, Madhuri Chintala, Gayathri Varikuti, Nagaseshu Pudi, Seema Kumari, Vijaya Rachel Kappala, Rama Rao Malla
PURPOSE: Lipid rafts are cholesterol enriched microdomains that colocalize signaling pathways involved in cell proliferation, metastasis, and angiogenesis. We examined the effect of methyl-β-cyclodextrin (MβCD)-mediated cholesterol extraction on the proliferation, adhesion, invasion, and angiogenesis of triple negative breast cancer (TNBC) cells. METHODS: We measured cholesterol and estimated cell toxicity. Detergent resistant membrane (DRM) and non-DRM fractions were separated using the OptiPrep gradient method...
December 2016: Journal of Breast Cancer
https://www.readbyqxmd.com/read/28051864/identification-and-characterization-of-glycopeptides-from-egg-protein-ovomucin-with-anti-agglutinating-activity-against-porcine-k88-enterotoxigenic-escherichia-coli-strains
#14
Xiaohong Sun, Michael G Gänzle, Jianping Wu
Ovomucin is a glycoprotein from egg white with potential to act as an anti-adhesive agent against infectious diseases. This study aimed to determine whether ovomucin or ovomucin hydrolysates could prevent adhesion to two porcine K88 enterotoxigenic Escherichia coli (ETEC) strains. Adhesion was determined in vitro using hemagglutination assay. Ovomucin hydrolysates, but not intact ovomucin, prevented ETEC adhesion to porcine erythrocytes. Ovomucin hydrolysate prepared by acid protease II exhibited the best anti-agglutinating activity against both strains; this hydrolysate was fractionated by cation exchange chromatography and reverse-phase HPLC...
January 4, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28044245/mri-detection-of-endothelial-cell-inflammation-using-targeted-superparamagnetic-particles-of-iron-oxide-spio
#15
Joyce M S Chan, Maggie S H Cheung, Richard G J Gibbs, Kishore K Bhakoo
BACKGROUND: There is currently no clinical imaging technique available to assess the degree of inflammation associated with atherosclerotic plaques. This study aims to develop targeted superparamagnetic particles of iron oxide (SPIO) as a magnetic resonance imaging (MRI) probe for detecting inflamed endothelial cells. METHODS: The in vitro study consists of the characterisation and detection of inflammatory markers on activated endothelial cells by immunocytochemistry and MRI using biotinylated anti-P-selectin and anti-VCAM-1 (vascular cell adhesion molecule 1) antibody and streptavidin conjugated SPIO...
December 2017: Clinical and Translational Medicine
https://www.readbyqxmd.com/read/28035597/identification-of-essential-genes-of-pseudomonas-aeruginosa-for-its-growth-in-airway-mucus
#16
Mohammed Abd Alrahman, Sang Sun Yoon
Pseudomonas aeruginosa has been identified as an important causative agent of airway infection, mainly in cystic fibrosis. This disease is characterized by defective mucociliary clearance induced in part by mucus hyper-production. Mucin is a major component of airway mucus and is heavily O-glycosylated, with a protein backbone. Airway infection is known to be established with bacterial adhesion to mucin. However, the genes involved in mucin degradation or utilization remain elusive. In this study, we sought to provide a genetic basis of P...
January 2017: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/28027493/hydrophilic-modification-of-intraocular-lens-via-surface-initiated-reversible-addition-fragmentation-chain-transfer-polymerization-for-reduced-posterior-capsular-opacification
#17
Quankui Lin, Junmei Tang, Yuemei Han, Xu Xu, Xiaojuan Hao, Hao Chen
Phacoemulsification followed with intraocular lens (IOL) implantation is the most effective clinical surgeries in treating cataracts. However, posterior capsular opacification (PCO), a common complication of this surgery, may cause vision decrease after surgery. PCO is mainly caused by the adhesion, proliferation and trans-differentiation of the residual lens epithelial cells (LEC) after surgery. Surface modification of IOL to reduce the LEC adhesion is of great importance in PCO prevention. Herein, surface initiated reversible addition-fragmentation chain transfer (SI-RAFT) polymerization was utilized to modify the IOL materials for generating a comb-like polyethylene glycol (PEG) brush coating on the surface...
December 21, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28019097/multifunctional-self-adhesive-fibrous-layered-matrix-film-for-tissue-glues-and-therapeutic-carriers
#18
Ye-Eun Yoon, Byung Gee Im, Jung-Suk Kim, Jae-Hyung Jang
Tissue adhesives, which inherently serve as wound sealants or as hemostatic agents, can be further augmented to acquire crucial functions as scaffolds, thereby accelerating wound healing or elevating the efficacy of tissue regeneration. Herein, multifunctional adherent fibrous matrices, acting as self-adhesive scaffolds capable of cell/gene delivery, were devised by coaxially electrospinning poly(caprolactone) (PCL) and poly(vinylpyrrolidone) (PVP). Wrapping the building block PCL fibers with the adherent PVP layers formed film-like fibrous matrices that could rapidly adhere to wet biological surfaces, referred to as fibrous layered matrix (FiLM) adhesives...
December 26, 2016: Biomacromolecules
https://www.readbyqxmd.com/read/28017156/sugar-based-biopolymers-in-nanomedicine-new-emerging-era-for-cancer-imaging-and-therapy
#19
Mehmet S Eroglu, Ebru Toksoy Oner, Esra Cansever Mutlu, Muge Sennaroglu Bostan
Since last decade, sugar based biopolymers are recognized in nanomedicine as promising materials for cancer imaging and therapy. Their durable, biocompatible and adhesive properties enable the fine tuning of their molecular weights (MW) and their miscellaneous nature makes the molecules acquire various conformations. These in turn provide effective endocytosis by cancer cell membranes that have already been programmed for internalization of different kinds of sugars. Therefore, biocompatible sugar based nanoparticles (SBNPs) are suitable for both cell-selective delivery of drugs and imaging through the human body...
December 21, 2016: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/28011480/synergistically-anti-metastatic-effect-of-5-flourouracil-on-colorectal-cancer-cells-via-calcium-mediated-focal-adhesion-kinase-proteolysis
#20
Minhee Park, Pasupathi Sundaramoorthy, Jae Jun Sim, Keun-Yeong Jeong, Hwan Mook Kim
AIM: To investigate the possibility of enhancing an anti-metastatic effect of 5-fluorouracil (5-FU) on colorectal cancer (CRC) cells by combining it with continuous calcium supplementation. MATERIALS AND METHODS: Optimal doses of 5-FU with/without lactate salt (CaLa) were determined via clonogenicity and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays using human CRC cells cultured on normal or low-attachment plates. Invasion and migration assays confirmed the enhanced anti-metastatic effect of combining 5-FU and CaLa...
January 2017: Anticancer Research
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