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https://www.readbyqxmd.com/read/28110309/close-connections-between-contraction-and-rhythm-a-new-genetic-cause-of-atrial-fibrillation-cardiomyopathy-and-what-it-can-teach-us
#1
EDITORIAL
Stanley Nattel
No abstract text is available yet for this article.
January 1, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28110304/dipole-density-mapping-of-atrial-fibrillation
#2
Andrew Grace, Atul Verma, Stephan Willems
No abstract text is available yet for this article.
January 1, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28110303/stroke-prevention-in-atrial-fibrillation
#3
Gregory Y H Lip
No abstract text is available yet for this article.
January 1, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28110302/atrial-fibrillation-beyond-the-arrhythmia-hypercoagulability-adipose-tissue-and-fibrotic-remodelling
#4
Thomas F Lüscher
No abstract text is available yet for this article.
January 1, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28110293/increased-use-of-oral-anticoagulants-in-patients-with-atrial-fibrillation-temporal-trends-from-2005-to-2015-in-denmark
#5
Kasper Gadsbøll, Laila Staerk, Emil Loldrup Fosbøl, Caroline Sindet-Pedersen, Anna Gundlund, Gregory Y H Lip, Gunnar Hilmar Gislason, Jonas Bjerring Olesen
AIM: The aim of this study is to examine temporal trends in the use oral anticoagulants (OAC) as stroke prophylaxis in patients with atrial fibrillation (AF) and to examine factors associated with OAC initiation. METHODS AND RESULTS: From Danish nationwide registries, we identified patients diagnosed with AF at Danish hospitals and outpatient clinics between January 2005 and June 2015. OAC initiation was assessed from prescription fills ±180 days from date of AF diagnosis...
January 21, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28110125/chemical-defined-and-albumin-free-generation-of-human-atrial-and-ventricular-myocytes-from-human-pluripotent-stem-cells
#6
Fei Pei, Junjie Jiang, Shuyun Bai, Henghua Cao, Luyang Tian, Ya Zhao, Chuanxiu Yang, Haiheng Dong, Yue Ma
Most existing culture media for cardiac differentiation of human pluripotent stem cells (hPSCs) contain significant amounts of albumin. For clinical transplantation applications of hPSC-derived cardiomyocytes (hPSC-CMs), culturing cells in an albumin containing environment raises the concern of pathogen contamination and immunogenicity to the recipient patients. In addition, batch-to-batch variation of albumin may cause the inconsistent of hPSC cardiac differentiation. Here, we demonstrated that antioxidants l-ascorbic acid, trolox, N-acetyl-l-cysteine (NAC) and sodium pyruvate could functionally substitute albumin in the culture medium, and formulated an albumin-free, chemical-defined medium (S12 medium)...
January 12, 2017: Stem Cell Research
https://www.readbyqxmd.com/read/28109936/precision-phenotyping-in-heart-failure-and-pattern-clustering-of-ultrasound-data-for-the-assessment-of-diastolic-dysfunction
#7
Alaa Mabrouk Salem Omar, Sukrit Narula, Mohamed Ahmed Abdel Rahman, Gianni Pedrizzetti, Hala Raslan, Osama Rifaie, Jagat Narula, Partho P Sengupta
OBJECTIVES: The aim of this study was to investigate whether cluster analysis of left atrial and left ventricular (LV) mechanical deformation parameters provide sufficient information for Doppler-independent assessment of LV diastolic function. BACKGROUND: Medical imaging produces substantial phenotyping data, and superior computational analyses could allow automated classification of repetitive patterns into patient groups with similar behavior. METHODS: The authors performed a cluster analysis and developed a model of LV diastolic function from an initial exploratory cohort of 130 patients that was subsequently tested in a prospective cohort of 44 patients undergoing cardiac catheterization...
January 11, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28109875/a-novel-percutaneous-technique-using-lasso-catheters-for-retrieval-of-an-embolized-amplatzer-atrial-septal-occluder-device
#8
Santosh K Padala, Aditya Saini, Zachary M Gertz, Gordon S Morano, Kenneth A Ellenbogen, Jayanthi N Koneru
No abstract text is available yet for this article.
January 11, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28109578/liver-fibrogenesis-marker-7s-domain-of-collagen-type-iv-in-patients-with-acutely-decompensated-heart-failure-correlates-prognostic-value-and-time-course
#9
Kazuya Nagao, Akinori Tamura, Takeshi Morimoto, Kiyotaka Shimamura, Hiroshi Yukawa, Haruyasu Ito, Fujio Hayashi, Toshinori Makita, Genzou Takemura, Yukihito Sato, Tsukasa Inada, Takeshi Kimura, Masaru Tanaka
BACKGROUND: Congestion in heart failure (HF) induces multiple organ injury, which may cause remodeling of extracellular matrix. We hypothesized that liver fibrogenesis marker, 7S domain of collagen type IV (P4NP 7S) was correlated with congestion and liver injury in HF. METHODS AND RESULTS: We measured serum P4NP 7S in two cohorts. Cohort 1 included 70 patients undergoing catheterization. P4NP 7S was correlated with pulmonary capillary wedge pressure, right ventricular and atrial pressure (r=0...
January 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28109525/wire-and-needle-potentials-facilitating-transseptal-puncture
#10
Konstantin M Heinroth, Thomas Hartkopf, Alexander Plehn, Joachim Wilhelm, Susanne Unverzagt, Stefan Frantz, Alexander Schirdewan
BACKGROUND: Transseptal puncture for left heart interventions became a routine procedure guided by fluoroscopy and echocardiography. The use of intracardiac potentials derived from the sheath-transseptal-needle/guidewire-combination may provide helpful information to increase safety of this procedure. METHODS AND RESULTS: We recorded the intracardiac potentials from the sheath-transseptal-needle/guidewire-combination during the transseptal puncture procedure in 31 consecutive patients (mean age 67...
January 15, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28109396/safe-surgical-retrieval-of-embolized-atrial-septal-defect-closure-device
#11
Martin T Yates, David R Anderson
Surgical retrieval of atrial septal closure device is associated with significant morbidity. We present a technique for safer removal of such devices from the heart.
February 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28109384/failing-systemic-right-ventricles-with-persistent-pulmonary-hypertension-candidates-for-ventricular-assist-devices-as-destination-therapy
#12
Ophelie Loup, Kerstin Wustmann, Michele Vittorio Martinelli, Markus Schwerzmann, Paul Mohacsi, Thierry Pierre Carrel, Alexander Kadner
Dysfunction of the systemic right ventricle is common after the atrial switch procedure for transposition of the great arteries. Cardiac transplantation remains the only long-term solution in terminal systemic right ventricular (RV) failure, but concomitant pulmonary hypertension (PHT) may preclude it. The increasing number of such patients, together with the concerns related to combined heart-lung transplantation (HLTx), urge us to consider other therapeutic options.
February 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28109316/adenosine-induced-ventricular-fibrillation-in-a-structurally-normal-heart-a-case-report
#13
Christopher A Rajkumar, Norman Qureshi, Fu Siong Ng, Vasileios F Panoulas, Phang Boon Lim
BACKGROUND: Adenosine is the first-line pharmacotherapy for termination of supraventricular tachycardia through its action on the atrioventricular node. However, pro-arrhythmic effects of adenosine are also recognised, most notably in the presence of pre-excited atrial fibrillation. In this case report, we describe the induction of ventricular fibrillation in a patient with no demonstrable accessory pathway, nor any other structural heart disease. This rare, idiosyncratic reaction has never previously been reported and is of relevance given the widespread and routine use of adenosine in clinical practice...
January 22, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28109125/evaluation-of-left-atrial-function-via-two-dimensional-speckle-tracking-echocardiography-in-patients-with-coronary-artery-ectasia
#14
Hasan Aghajani, Mohsen Faal, Ali Hosseinsabet, Reza Mohseni-Badalabadi
BACKGROUND: Coronary artery ectasia (CAE) is a segmental dilation of an epicardial coronary artery. Our aim was to evaluate the left atrial (LA) function in patients with CAE. METHODS: Twenty-seven consecutive patients with CAE and 33 subjects without significant coronary artery disease were included in our study. LA function was evaluated with two-dimensional speckle-tracking echocardiography (2DSTE). RESULTS: The systolic, early diastolic and late diastolic strains and strain rates were not statistically significantly different between the two groups...
January 21, 2017: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/28108954/transcatheter-closure-of-an-atrial-septal-defect-with-high-risk-of-erosion-using-a-figulla-flex-ii-atrial-septal-defect-occluder
#15
Norio Tada, Yukiko Mizutani, Takashi Matsumoto, Mie Sakurai, Tatsushi Ootomo
An 85-year-old man with a high risk for open heart surgery underwent a percutaneous closure of an atrial septal defect that lacked adequate aortic and superior rims. To avoid the risk for erosion, a Figulla Flex II ASD occluder was selected for the procedure. Implantation was successful, and no complications were observed during the 6 months of follow-up.
January 20, 2017: Cardiovascular Intervention and Therapeutics
https://www.readbyqxmd.com/read/28108860/early-cardioversion-in-atrial-fibrillation-earlier-is-better-but-not-always-and-maybe-not-immediately
#16
REVIEW
Paloma G Piña, Alexandru B Chicos
Atrial fibrillation (AF) is the most common cardiac arrhythmia in humans. One of its important features is the tendency to become more persistent over time, even in the absence of underlying progressive heart disease. Conversion and maintenance of sinus rhythm by pharmacological or electrical methods become increasingly difficult the longer the arrhythmia persists. Electrical, mechanical, structural, and autonomic remodeling processes have been implicated in the mechanisms of AF initiation, perpetuation, and progression...
January 2017: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/28108549/relation-of-renal-dysfunction-with-incident-atrial-fibrillation-and-cardiovascular-morbidity-and-mortality-the-prevend-study
#17
Ernaldo G Marcos, Bastiaan Geelhoed, Pim Van Der Harst, Stefan J L Bakker, Ron T Gansevoort, Hans L Hillege, Isabelle C Van Gelder, Michiel Rienstra
AIMS: Renal dysfunction is a risk factor for cardiovascular disease, including atrial fibrillation (AF) and mortality. However, the exact pathobiology linking different renal dysfunction measures, such as albumin excretion or glomerular filtration rate (GFR), to cardiovascular- and AF risk are unclear. In this study, we investigated the association of several renal function measures and incident AF, and whether the relation between renal measures and outcomes is modified by AF. METHODS AND RESULTS: We examined 8265 individuals (age 49 ± 13 years, 50% women) included in the PREVEND study...
January 20, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28108547/characterising-the-difference-in-electrophysiological-substrate-and-outcomes-between-heart-failure-and-non-heart-failure-patients-with-persistent-atrial-fibrillation
#18
Shouvik K Haldar, David G Jones, Habib Khan, Sandeep Panikker, Julian W E Jarman, Charlie Butcher, Eric Lim, Gareth Wynn, Dhiraj Gupta, Wajid Hussain, Vias Markides, Tom Wong
AIMS: Characterizing the differences in substrate and clinical outcome between heart failure (HF) and non-heart failure (non-HF) patients undergoing persistent atrial fibrillation (AF) ablation. METHODS AND RESULTS: Using complex fractionated electrograms (CFE) as a surrogate marker of substrate complexity, we compared the bi-atrial substrate in patients with persistent AF with and without HF, at baseline and after ablation, to determine its impact on clinical outcome...
January 20, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28108014/electrocardiographic-spatial-loops-indicate-organization-of-atrial-fibrillation-minutes-before-ablation-related-transitions-to-atrial-tachycardia
#19
Tina Baykaner, Rishi Trikha, Junaid A B Zaman, David E Krummen, Paul J Wang, Sanjiv M Narayan
BACKGROUND: During ablation for atrial fibrillation (AF), it is challenging to anticipate transitions to organized tachycardia (AT). Defining indices of this transition may help to understand fibrillatory conduction and help track therapy. OBJECTIVE: To determine the timescale over which atrial fibrillation (AF) organizes en route to atrial tachycardia (AT) using the ECG referenced to intracardiac electrograms. METHODS: In 17 AF patients at ablation (58...
January 15, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28107569/use-of-higher-maximum-doses-and-infusion-rates-compared-with-those-used-in-standard-unfractionated-heparin-therapy-is-associated-with-adequate-anticoagulation-without-increased-bleeding-in-both-obese-and-nonobese-patients-with-cardiovascular-indications
#20
Catherine K Floroff, Nicole M Palm, Daniel H Steinberg, Eric R Powers, Barbara S Wiggins
STUDY OBJECTIVE: To evaluate the time to achieve therapeutic activated partial thromboplastin time (aPTT) values and occurrence of bleeding based on standard unfractionated heparin (UFH) weight-based dosing recommendations compared with an aggressive weight-based UFH dosing strategy using higher maximum doses and infusion rates in both obese and nonobese patients who presented with non-ST-Segment Elevation Myocardial Infarction or unstable angina (NSTEMI/UA) or atrial fibrillation. DESIGN: Retrospective cohort study...
January 20, 2017: Pharmacotherapy
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