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https://www.readbyqxmd.com/read/29055248/simultaneous-quantification-of-direct-oral-anticoagulants-currently-used-in-anticoagulation-therapy
#1
Kathrin I Foerster, Andrea Huppertz, Oliver J Müller, Timolaos Rizos, Lisa Tilemann, Walter E Haefeli, Jürgen Burhenne
Direct oral anticoagulants (DOACs) are among the most effective options to prevent serious thromboembolic events in patients with atrial fibrillation. Coagulation assays are used to assess DOAC activity, but lack the possibility to quantify drugs with concurrent pharmacodynamic effect. We developed a selective multi-drug assay to analyze apixaban, betrixaban, dabigatran, edoxaban, edoxaban M4, and rivaroxaban with ultra-performance liquid chromatography coupled to tandem mass spectrometry (UPLC/MS/MS) in plasma fulfilling all requirements of the FDA und EMA guidelines for bioanalytical method validation...
October 16, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29054930/the-transcription-factor-mef2a-fine-tunes-gene-expression-in-the-atrial-and-ventricular-chambers-of-the-adult-heart
#2
Jose L Medrano, Francisco J Naya
The distinct morphological and functional properties of the cardiac chambers arise from an elaborate developmental program involving cell lineage determination, morphogenesis, and dynamic spatiotemporal gene expression patterns. While a number of transcription factors have been identified for proper gene regulation in the chambers, the complete transcriptional network that controls these patterns remains poorly defined. Previous studies have implicated the MEF2C transcription factor in the regulation of chamber-restricted enhancers...
October 20, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29054845/does-moderate-drinking-increase-the-risk-of-atrial-fibrillation-the-norwegian-hunt-nord-tr%C3%A3-ndelag-health-study
#3
Katalin Gémes, Vegard Malmo, Lars Erik Laugsand, Jan Pål Loennechen, Hanne Ellekjaer, Krisztina D László, Staffan Ahnve, Lars J Vatten, Kenneth J Mukamal, Imre Janszky
BACKGROUND: Compelling evidence suggests that excessive alcohol consumption increases the risk of atrial fibrillation (AF), but the effect of light-moderate alcohol consumption is less certain. We investigated the association between alcohol consumption within recommended limits and AF risk in a light-drinking population. METHODS AND RESULTS: Among 47 002 participants with information on alcohol consumption in a population-based cohort study in Norway, conducted from October 2006 to June 2008, 1697 validated AF diagnoses were registered during the 8 years of follow-up...
October 20, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29054839/incremental-prognostic-utility-of-left-ventricular-global-longitudinal-strain-in-hypertrophic-obstructive-cardiomyopathy-patients-and-preserved-left-ventricular-ejection-fraction
#4
Albree Tower-Rader, Jorge Betancor, Zoran B Popovic, Kimi Sato, Maran Thamilarasan, Nicholas G Smedira, Harry M Lever, Milind Y Desai
BACKGROUND: In obstructive hypertrophic cardiomyopathy patients with preserved left ventricular (LV) ejection fraction, we sought to determine whether LV global longitudinal strain (LV-GLS) provided incremental prognostic utility. METHODS AND RESULTS: We studied 1019 patients with documented hypertrophic cardiomyopathy (mean age, 50±12 years; 63% men) evaluated at our center between 2001 and 2011. We excluded age <18 years, maximal LV outflow tract gradient <30 mm Hg, bundle branch block or atrial fibrillation, past pacemaker/cardiac surgery, including myectomy/alcohol ablation, and obstructive coronary artery disease...
October 20, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29054780/safe-burr-hole-surgery-for-chronic-subdural-hematoma-using-dabigatran-with-idarucizumab
#5
Nobuhiko Arai, Yutaka Mine, Hiroshi Kagami, Michiyuki Maruyama, Jun Daiko, Makoto Inaba
BACKGROUND: Chronic subdural hematoma (CSDH) is a common intracranial hematoma. The number of patients who undergo anticoagulant therapy including a direct oral anticoagulant (DOAC) is expected to increase. Recently, idarucizumab, the antidote for dabigatran, which is a DOAC, has been developed. We successfully treated CSDH with dabigatran using emergency burr hole surgery and idarucizumab. CASE DESCRIPTION: A 79-year-old Japanese man severely hit his head and visited the emergency room (ER)...
October 17, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29054242/pulmonary-vein-widening-plasty-for-pulmonary-vein-stenosis-and-occlusion-after-catheter-ablation
#6
Bart P Van Putte, Tim Smith, Thom L De Kroon, Ralph J Damiano
We successfully performed a pulmonary vein widening plasty in a patient with pulmonary vein stenosis and occlusion after multiple catheter ablations for paroxysmal atrial fibrillation.
November 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29054237/systemic-venous-rerouting-through-the-coronary-sinus-for-cctga-with-bilateral-svcs
#7
Satoshi Asada, Masaaki Yamagishi, Takako Miyazaki, Yoshinobu Maeda, Satoshi Taniguchi, Shuhei Fujita, Hisayuki Hongu, Hitoshi Yaku
The double-switch operation for congenitally corrected transposition of the great arteries, in which the morphologic left ventricle is restored to the systemic circulation, is an effective surgical option. This case report describes an atrial switch technique without using supplemental material during the double-switch operation for congenitally corrected transposition of the great arteries associated with persistent left superior vena cava, with the systemic venous blood flow rerouted through the enlarged coronary sinus...
November 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29054235/acquired-cor-triatriatum-sinister-after-the-fontan-operation-and-successful-resection-in-a-child
#8
S Javed Zaidi, Rishi R Adhikari, Chawki El-Zein, Saad Siddiqui
Cor triatriatum sinister is a rare congenital lesion encountered in children. It consists of a fibromuscular membrane that separates the left atrium into two chambers resulting in a triatrial heart and often occurs with other structural cardiac anomalies. The acquired form is uncommon and has only been reported after orthotopic heart transplantation or as a complication of infective endocarditis in adults. These cases were mostly because of hypertrophied atrial tissue or suture lines and torsion of the atrium...
November 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29054227/life-threatening-cardiac-perforation-after-posterior-spondylodesis
#9
Michaela Andrä, Harald Baumer, Florian Mittergradnegger, Michael Laschitz, Tadej Petek, Wolfgang Wandschneider
This reports presents a case of a 62-year-old woman with hemorrhagic hypovolemic shock, respiratory distress, and pericardial effusion secondary to right atrial perforation caused by a cement embolus after dorsal spondylodesis. Despite optimal intensive care support for a supposed pulmonary embolism, the patient's condition markedly deteriorated. On delayed embolus recognition by contrast-enhanced computed tomography and transesophageal echocardiography, she had to undergo cardiac surgery. Cardiac involvement is a rare but important complication, with few cases described after vertebroplasty and none after spondylodesis...
November 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29054204/electroceuticals-in-medicine-the-brave-new-future
#10
Sundeep Mishra
Electroceuticals are a new category of therapeutic agents which act by targeting the neural circuits of organs. The therapy involves mapping the neural circuitry and delivering neural impulses to these specific targets. The impulse is administered via an implantable device. In cardiology besides pacemaker, defibrillation and resynchronization applications it could have usefulness in heart failure, atrial fibrillation, coronary artery disease, myocarditis, resistant hypertension, atrial and ventricular tachyarrhythmias, pulseless electrical activity, and refractory angina...
September 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/29054201/electrocardiographic-features-various-atrial-site-pacing
#11
REVIEW
Asit Das
Atrial pacing is done for either symptomatic sinus node dysfunction (SND) or for maintenance of atrio-ventricular synchrony in a dual chamber pacemaker. Conventionally, atrial lead is placed in the right atrial appendage. Atrial conduction disorder in patients with permanent pacing results in higher incidence of atrial fibrillation. Atrial septal pacing has emerged as a solution to this problem. So, it is extremely important to understand the different features of paced P wave from various atrial pacing sites...
September 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/29054200/the-role-of-acute-circulatory-support-in-st-segment-elevation-myocardial-infarction-complicated-by-cardiogenic-shock
#12
REVIEW
Michele Esposito, Yousef Bader, Robert Pedicini, Catalina Breton, Andrew Mullin, Navin K Kapur
In the setting of ST-segment elevation myocardial infarction (STEMI) complicated by cardiogenic shock, three primary treatment objectives include providing circulatory support, ventricular unloading, and restoring myocardial perfusion. In addition to primary percutaneous coronary intervention, each of these three objectives can be achieved with appropriate use of an acute mechanical circulatory support (AMCS) pump. Over the past decade, utilization of percutaneously-delivered AMCS devices including the Impella axial-flow catheter, TandemHeart left atrial-to-femoral artery bypass system, and veno-arterial extracorporeal membrane oxygenation (VA-ECMO) has grown exponentially...
September 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/29053020/cardiovascular-outcomes-for-patients-with-symptomatic-peripheral-artery-disease-a-cohort-study-in-the-health-improvement-network-thin-in-the-uk
#13
Lucía Cea Soriano, F Gerry R Fowkes, Saga Johansson, Alaster M Allum, Luis A García Rodriguez
Background Few data are available on risk factors and associations with outcomes in symptomatic peripheral artery disease (PAD) populations in primary care. We assessed characteristics and cardiovascular outcomes in patients with and those without symptomatic peripheral artery disease in UK primary care, and quantified risk factors for cardiovascular outcomes in patients with peripheral artery disease. Methods Among patients in The Health Improvement Network (THIN) aged 50-89 years in 2000-2010, a symptomatic peripheral artery disease cohort ( n = 28,484) and a matched comparison cohort without peripheral artery disease ( n = 113,940) were identified using Read codes...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29052577/effect-of-shen-song-yang-xin-capsule-on-myocardial-electrophysiology-of-acute-atrial-fibrillation-in-canine-model
#14
Kai Zhang, Liang Shi, Hai-Jiao Tang, Long Yang, Xin-Chun Yang
No abstract text is available yet for this article.
October 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/29052435/high-overall-cardiovascular-risk-and-mortality-in-patients-with-atrial-fibrillation-and-diabetes-a-nationwide-report
#15
Stelios Karayiannides, Pia Lundman, Leif Friberg, Anna Norhammar
AIM: To describe nationwide complication patterns in patients with atrial fibrillation and diabetes mellitus. METHODS: All ( n = 326,832) patients in Sweden with non-valvular atrial fibrillation during 2006-2012 were identified, and information on events, comorbidities and pharmacological therapy was extracted using nationwide mandatory registers. Patients were followed until 31 December 2013 and the mean follow-up time was 3.7 years (0.9-8 years). RESULTS: Diabetes was present in 17...
October 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29052299/a-functional-variant-in-the-promoter-region-regulates-the-c-reactive-protein-gene-and-is-a-potential-candidate-for-increased-risk-of-atrial-fibrillation
#16
(no author information available yet)
No abstract text is available yet for this article.
November 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29052116/patients-knowledge-on-oral-anticoagulant-treatment-in-hungary
#17
Reka Viola, Helga Fekete, Ildiko Csoka
Background A key element for an effective and safe oral anticoagulant treatment (OAT) is to have the relevant information delivered to patients in an easy-to-understand way and thus have them apply this knowledge in their own therapy. Objective To assess knowledge about OAT, reveal knowledge gaps and identify at-risk patients in terms of limited knowledge about their anticoagulant therapy. Setting Community pharmacies in Hungary. Methods This descriptive cross-sectional study used a structured, validated, self-developed questionnaire to assess patients' knowledge about OAT...
October 19, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29052104/anticoagulation-prescribing-patterns-in-patients-with-cancer
#18
Elaine Xiang, Tania Ahuja, Veronica Raco, Frank Cirrone, David Green, John Papadopoulos
Cancer is a known hypercoagulable state that leads to an increased risk of venous thromboembolism (VTE). Low molecular weight heparin remains the preferred anticoagulant for VTE in patients with cancer over vitamin K antagonist. However, the preferred anticoagulant in prevention of stroke and systemic embolism in atrial fibrillation (AF) in patients with cancer has yet to be determined. The direct oral anticoagulants (DOACs) are increasingly being utilized; however their role in cancer has only recently been investigated...
October 19, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29051131/left-atrial-appendage-occlusion-is-promising-not-concerning
#19
Kasper Korsholm, Jens Erik Nielsen-Kudsk
No abstract text is available yet for this article.
October 20, 2017: EuroIntervention
https://www.readbyqxmd.com/read/29051130/concerns-about-left-atrial-appendage-occlusion
#20
Claudia Stöllberger, Birke Schneider
No abstract text is available yet for this article.
October 20, 2017: EuroIntervention
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