keyword
MENU ▼
Read by QxMD icon Read
search

Diagnostic tool

keyword
https://www.readbyqxmd.com/read/28651408/-identification-and-evaluation-of-t-cell-epitopes-of-rv0585c-from-mycobacterium-tuberculosis
#1
X X Wang, X Chen, Y Q Li, T Y Xiao, Y Jiang, M C Li, H C Liu, K L Wan
Objective: To investigate the human T cell epitopes of Mycobacterium (M.) tuberculosis Rv0585c protein antigen and their immunogenicity and provide evidence for the development of specific tuberculosis immune diagnostic techniques and tuberculosis vaccine. Methods: We synthesized peptides from M. tuberculosis Rv0585c protein antigen predicted by TE-predict and IEDB human T cell epitope prediction tool. The cellular immunoreactivity of the predicted peptides was evaluated through ELISpot assay with the peripheral blood monouclear cells (PBMC) of clinical tuberculosis patients...
May 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28651293/-tuberculosis-guideline-for-adults-guideline-for-diagnosis-and-treatment-of-tuberculosis-including-ltbi-testing-and-treatment-of-the-german-central-committee-dzk-and-the-german-respiratory-society-dgp
#2
Tom Schaberg, Torsten Bauer, Folke Brinkmann, Roland Diel, Cornelia Feiterna-Sperling, Walter Haas, Pia Hartmann, Barbara Hauer, Jan Heyckendorf, Christoph Lange, Albert Nienhaus, Ralf Otto-Knapp, Martin Priwitzer, Elvira Richter, Rudolf Rumetshofer, Karl Schenkel, Otto Dagobert Schoch, Nicolas Schönfeld, Ralf Stahlmann
Since 2015 a significant increase in tuberculosis cases is notified in Germany, mostly due to rising numbers of migrants connected to the recent refugee crisis. Because of the low incidence in previous years, knowledge on tuberculosis is more and more limited to specialized centers. However, lung specialist and healthcare workers of other fields have contact to an increasing number of tuberculosis patients. In this situation, guidance for the management of standard therapy and especially for uncommon situations will be essential...
June 2017: Pneumologie
https://www.readbyqxmd.com/read/28650970/point-of-care-testing-for-toxoplasma-gondii-igg-igm-using-toxoplasma-ict-igg-igm-test-with-sera-from-the-united-states-and-implications-for-developing-countries
#3
Ian J Begeman, Joseph Lykins, Ying Zhou, Bo Shiun Lai, Pauline Levigne, Kamal El Bissati, Kenneth Boyer, Shawn Withers, Fatima Clouser, A Gwendolyn Noble, Peter Rabiah, Charles N Swisher, Peter T Heydemann, Despina G Contopoulos-Ioannidis, Jose G Montoya, Yvonne Maldonado, Raymund Ramirez, Cindy Press, Eileen Stillwaggon, François Peyron, Rima McLeod
BACKGROUND: Congenital toxoplasmosis is a serious but preventable and treatable disease. Gestational screening facilitates early detection and treatment of primary acquisition. Thus, fetal infection can be promptly diagnosed and treated and outcomes can be improved. METHODS: We tested 180 sera with the Toxoplasma ICT IgG-IgM point-of-care (POC) test. Sera were from 116 chronically infected persons (48 serotype II; 14 serotype I-III; 25 serotype I-IIIa; 28 serotype Atypical, haplogroup 12; 1 not typed)...
June 26, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28650932/incremental-value-of-right-atrial-strain-for-early-diagnosis-of-hemodynamic-deterioration-in-pulmonary-hypertension-a-new-noninvasive-tool-for-a-more-comprehensive-diagnostic-paradigma
#4
Cristina Piccinino, Ailia Giubertoni, Jacopo Zanaboni, Miriam Gravellone, Daniele Sola, Roberta Rosso, Lorena Ferrarotti, Paolo Nicola Marino
AIMS: Increased right atrial size is related to adverse prognosis in pulmonary hypertension. The potential incremental value of right atrial function assessment is still unclear. We tested the relationship between right atrial two-dimensional speckle-tracking echocardiography impairment and hemodynamic, functional and clinical deterioration in patients with pulmonary hypertension. METHODS: We prospectively evaluated 36 patients (27 female, 9 male; mean age 68 ± 13 years) with suspected pulmonary hypertension undergoing right heart catheterization and 16 matched controls...
June 24, 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/28650811/regularized-spectral-log-difference-technique-for-ultrasonic-attenuation-imaging
#5
Andres L Coila, Roberto J Lavarello
The attenuation coefficient slope (ACS) has the potential to be used for tissue characterization and as a diagnostic ultrasound tool, hence complementing B-mode images. The ACS can be valuable for estimation of other ultrasound parameters such as the backscatter coefficient. There is a well-known trade-off between the precision of the estimated ACS values and the data block size used in spectral-based techniques such as the spectral log difference (SLD). This trade-off limits the practical usefulness of spectral-based attenuation imaging techniques...
June 26, 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28650518/a-simple-in-silico-strategy-identifies-candidate-biomarkers-for-the-diagnosis-of-liver-fibrosis-in-morbidly-obese-subjects
#6
Pablo J Giraudi, Sabrina E Gambaro, Sofia Ornelas Arroyo, Carla M Chackelevicius, Michela Giuricin, Marta Silvestri, Daniele Macor, Lory S Crocé, Deborah Bonazza, Giorgio Soardo, Nicolò de Manzini, Fabrizio Zanconati, Claudio Tiribelli, Silvia Palmisano, Natalia Rosso
BACKGROUND AND AIMS: Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disorder, tightly associated with obesity. The histological spectrum of the disease ranges from simple steatosis to steatohepatitis, with different stages of fibrosis, and fibrosis stage is the most significant predictor of mortality in NAFLD. Liver biopsy continues to be the gold standard for its diagnosis and reliable non-invasive diagnostic tools are unavailable. We investigated the accuracy of candidate proteins, identified by an in silico approach, as biomarkers for diagnosis of fibrosis...
June 26, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28650510/experiment-and-theory-confirm-that-uv-laser-photodissociation-spectroscopy-can-distinguish-protomers-formed-via-electrospray
#7
Edward Matthews, Caroline E H Dessent
The identification of protonation sites in electrosprayed molecules remains a challenge in contemporary physical science. We present the first demonstration that low-resolution, UV laser photodissociation spectroscopy can be applied in situ to identify the protomers of para-aminobenzoic acid (PABA) formed via electrospray from a single solution. Electronic absorption spectra are recorded via photodepletion and photofragmentation for PABA electrosprayed from solutions of water and acetonitrile. Using this approach, two protomers can be straightforwardly identified, with only the carboxylic acid protomer being produced on electrospray from water while the amine-protonated isomer dominates upon electrospray from acetonitrile...
June 26, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28650235/evaluation-of-infrared-thermography-as-a-diagnostic-tool-to-predict-heat-stress-events-in-feedlot-cattle
#8
Ellen M Unruh, Miles E Theurer, Brad J White, Robert L Larson, James S Drouillard, Nora Schrag
OBJECTIVE To determine whether infrared thermographic images obtained the morning after overnight heat abatement could be used as the basis for diagnostic algorithms to predict subsequent heat stress events in feedlot cattle exposed to high ambient temperatures. ANIMALS 60 crossbred beef heifers (mean ± SD body weight, 385.8 ± 20.3 kg). PROCEDURES Calves were housed in groups of 20 in 3 pens without any shade. During the 6 am and 3 pm hours on each of 10 days during a 14-day period when the daily ambient temperature was forecasted to be > 29...
July 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28649956/the-ati-score-age-thrombotic-burden-index-of-microcirculatory-resistance-determined-during-primary-percutaneous-coronary-intervention-predicts-final-infarct-size-in-patients-with-st-elevation-myocardial-infarction-a-cardiac-magnetic-resonance-validation-study
#9
Giovanni Luigi De Maria, Mohammad Alkhalil, Mathias Wolfrum, Gregor Fahrni, Alessandra Borlotti, Lisa Gaughran, Sam Dawkins, Jeremy Langrish, Andrew Lucking, Robin Choudhury, Italo Porto, Filippo Crea, Erica Dall'Armellina, Keith Channon, Rajesh Kharbanda, Adrian Banning
AIMS: The age-thrombus score-index of microcirculatory resistance (ATI) score is a diagnostic tool able to predict suboptimal myocardial reperfusion before stenting, in patients with ST elevation myocardial infarction (STEMI). We aimed to validate the ATI score against cardiac magnetic resonance imaging (cMRI). METHODS AND RESULTS: The ATI score was calculated prospectively in 80 STEMI patients. cMRI was performed within 48 hours in all patients and in 50 patients at six months follow up to assess the extent of infarct size (IS%) and microvascular obstruction (MVO%)...
June 27, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28649949/diagnostic-performance-of-a-lattice-boltzmann-based-method-for-fast-ct-fractional-flow-reserve
#10
Andreas Giannopoulos, Anji Tang, Yin Ge, Michael Cheezum, Michael Steigner, Shinichiro Fujimoto, Kanako Kumamaru, Dante Chiappino, Daniele Della Latta, Sergio Berti, Sara Chiappino, Frank Rybicki, Simone Melchionna, Dimitrios Mitsouras
AIMS: Fractional flow reserve (FFR) estimated from coronary computed tomography angiography (CT-FFR) offers non-invasive detection of lesion-specific ischemia. We developed and validated a fast CT-FFR algorithm utilizing the Lattice-Boltzmann Method for blood flow simulation (LBM CT-FFR). METHODS AND RESULTS: 64 patients from 3 institutions with clinically-indicated CTA and invasive FFR measurement were retrospectively analyzed. CT-FFR was performed using an on-site tool interfacing with a commercial Lattice-Boltzmann fluid dynamics cloud-based platform...
June 27, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28649310/lung-ultrasound-has-limited-diagnostic-value-in-rare-cystic-lung-diseases-a-cross-sectional-study
#11
Jesper Rømhild Davidsen, Elisabeth Bendstrup, Daniel P Henriksen, Ole Graumann, Christian B Laursen
Background: Lung ultrasound (LUS) used to identify interstitial syndrome (IS) and pleural thickening related to diffuse parenchymal lung disease (DPLD) has shown significant correlations with ground glass opacity (GGO) on high-resolution computed tomography (HRCT). However, the applicability of LUS in patients with DPLD subtypes as rare cystic lung diseases has not previously been investigated. This study aimed to observe if distinctive LUS findings could be found in patients with lymphangioleiomyomatosis (LAM), pulmonary Langerhans cell histiocytosis (PLCH), and Birt-Hogg-Dubé syndrome (BHDS)...
2017: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28649245/camelid-single-domain-antibodies-as-an-alternative-to-overcome-challenges-related-to-the-prevention-detection-and-control-of-neglected-tropical-diseases
#12
REVIEW
Carla F C Fernandes, Soraya Dos S Pereira, Marcos B Luiz, Juliana P Zuliani, Gilvan P Furtado, Rodrigo G Stabeli
Due mainly to properties such as high affinity and antigen specificity, antibodies have become important tools for biomedical research, diagnosis, and treatment of several human diseases. When the objective is to administer them for therapy, strategies are used to reduce the heterologous protein immunogenicity and to improve pharmacokinetic and pharmacodynamic characteristics. Size minimization contributes to ameliorate these characteristics, while preserving the antigen-antibody interaction site. Since the discovery that camelids produce functional antibodies devoid of light chains, studies have proposed the use of single domains for biosensors, monitoring and treatment of tumors, therapies for inflammatory and neurodegenerative diseases, drug delivery, or passive immunotherapy...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28649237/outer-membrane-vesicles-omvs-of-gram-negative-bacteria-a-perspective-update
#13
REVIEW
Arif Tasleem Jan
Outer Membrane Vesicles (OMVs) of Gram-negative bacteria are spherical membrane-enclosed entities of endocytic origin. Reported in the consortia of different bacterial species, production of OMVs into extracellular milieu seems essential for their survival. Enriched with bioactive proteins, toxins, and virulence factors, OMVs play a critical role in the bacteria-bacteria and bacteria-host interactions. Emergence of OMVs as distinct cellular entities helps bacteria in adaptating to diverse niches, in competing with other bacteria to protect members of producer species and more importantly play a crucial role in host-pathogen interaction...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28649159/initial-simulated-ffr-investigation-using-flow-measurements-in-patient-specific-3d-printed-coronary-phantoms
#14
Lauren Shepard, Kelsey Sommer, Richard Izzo, Alexander Podgorsak, Michael Wilson, Zaid Said, Frank J Rybicki, Dimitrios Mitsouras, Stephen Rudin, Erin Angel, Ciprian N Ionita
PURPOSE: Accurate patient-specific phantoms for device testing or endovascular treatment planning can be 3D printed. We expand the applicability of this approach for cardiovascular disease, in particular, for CT-geometry derived benchtop measurements of Fractional Flow Reserve, the reference standard for determination of significant individual coronary artery atherosclerotic lesions. MATERIALS AND METHODS: Coronary CT Angiography (CTA) images during a single heartbeat were acquired with a 320×0...
February 11, 2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/28649019/a-preliminary-study-for-the-production-of-high-specific-activity-radionuclides-for-nuclear-medicine-obtained-with-the-isotope-separation-on-line-technique
#15
F Borgna, M Ballan, S Corradetti, E Vettorato, A Monetti, M Rossignoli, M Manzolaro, D Scarpa, U Mazzi, N Realdon, A Andrighetto
Radiopharmaceuticals represent a fundamental tool for nuclear medicine procedures, both for diagnostic and therapeutic purposes. The present work aims to explore the Isotope Separation On-Line (ISOL) technique for the production of carrier-free radionuclides for nuclear medicine at SPES, a nuclear physics facility under construction at INFN-LNL. Stable ion beams of strontium, yttrium and iodine were produced using the SPES test bench (Front-End) to simulate the production of (89)Sr, (90)Y, (125)I and (131)I and collected with good efficiency on suitable targets...
June 17, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28648933/effectiveness-and-safety-of-two-18-gauge-needle-types-on-native-and-allograft-renal-biopsies
#16
Clarissa A Cassol, Juarez R Braga, Samer Dabbo, K Khalili, C Avila-Casado
Percutaneous biopsy is a key diagnostic tool for both native and allograft kidney diseases. Adequacy criteria vary, but at a minimum, a biopsy should allow the pathologist to reach a diagnosis and provide prognostic information such as the degree of interstitial fibrosis and tubular atrophy (IF/TA) and percentage of glomerulosclerosis. Whereas most studies use glomerular counts as a surrogate for biopsy adequacy, the amount and preservation of tubulointerstitium is equally important, considering IF/TA is a major prognostic parameter for most medical renal diseases...
June 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/28648396/25-years-of-serving-the-community-with-ribosomal-rna-gene-reference-databases-and-tools
#17
Frank Oliver Glöckner, Pelin Yilmaz, Christian Quast, Jan Gerken, Alan Beccati, Andreea Ciuprina, Gerrit Bruns, Pablo Yarza, Jörg Peplies, Ralf Westram, Wolfgang Ludwig
SILVA (lat. forest) is a comprehensive web resource, providing services around up to date, high-quality datasets of aligned ribosomal RNA gene (rDNA) sequences from the Bacteria, Archaea, and Eukaryota domains. SILVA dates back to the year 1991 when Dr. Wolfgang Ludwig from the Technical University Munich started the integrated software workbench ARB (lat. tree) to support high-quality phylogenetic inference and taxonomy based on the SSU and LSU rDNA marker genes. At that time, the ARB project maintained both, the sequence reference datasets and the software package for data analysis...
June 22, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28647501/driving-simulators-in-the-clinical-assessment-of-fitness-to-drive-in-sleepy-individuals-a-systematic-review
#18
REVIEW
David R Schreier, Christina Banks, Johannes Mathis
Road traffic injuries are projected to be the leading cause of death for those aged between 15 and 29 years by the year 2030, and sleepiness is estimated to be the underlying cause in up to 15-20% of all motor vehicle accidents. Sleepiness at the wheel is most often caused by socially induced sleep deprivation or poor sleep hygiene in otherwise healthy individuals, medical disorders, or the intake of drugs. Validated methods for objectifying sleepiness are urgently sought, particularly in the context of driving...
May 4, 2017: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/28647334/test-characteristics-of-milk-amyloid-a-elisa-somatic-cell-count-and-bacteriological-culture-for-detection-of-intramammary-pathogens-that-cause-subclinical-mastitis
#19
S Jaeger, F Virchow, P R Torgerson, M Bischoff, B Biner, S Hartnack, S R Rüegg
Bovine mastitis is an important disease in the dairy industry, causing economic losses as a result of withheld milk and treatment costs. Several studies have suggested milk amyloid A (MAA) as a promising biomarker in the diagnosis of mastitis. In the absence of a gold standard for diagnosis of subclinical mastitis, we estimated the diagnostic test accuracy of a commercial MAA-ELISA, somatic cell count (SCC), and bacteriological culture using Bayesian latent class modeling. We divided intramammary infections into 2 classes: those caused by major pathogens (e...
June 21, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28647160/a-clinical-decision-rule-to-predict-zygomatico-maxillary-fractures
#20
Simon Haworth, Anthony Bates, Andrea Beech, Greg Knepil
Patients presenting with periorbital trauma require clinical assessment to exclude zygomatico-maxillary fractures. A single-centre pilot investigation was undertaken at a general hospital in the United Kingdom. The sample was composed of 229 adult patients attending our emergency department with periorbital injuries. Findings from 17 signs or symptoms of facial injury were recorded on a validated tool. The relationship between clinical presentation and displaced zygomatico-maxillary fracture was assessed using diagnostic test parameters and tests for correlation...
May 25, 2017: Journal of Cranio-maxillo-facial Surgery
keyword
keyword
102264
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"