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https://www.readbyqxmd.com/read/28110503/impact-of-pancreatic-cyst-fluid-cea-levels-on-the-classification-of-pancreatic-cysts-using-the-papanicolaou-society-of-cytology-terminology-system-for-pancreaticobiliary-cytology
#1
Mauro Ajaj Saieg, Valerie Munson, Shanna Colletti, Aziza Nassar
BACKGROUND: The new proposed classification for pancreaticobiliary cytology has advocated the use of carcinoembryonic antigen (CEA) analysis of cyst fluid as an ancillary diagnostic tool for the determination of mucinous neoplasms in pancreatic cyst aspirates. We aimed to investigate the effect of CEA cyst fluid analysis on cases primarily called negative or nondiagnostic and on the sensitivity and specificity of the method. METHODS: We retrospectively identified and collected all pancreatic cyst aspirates from 2010 to 2014 at Mayo Clinic, Jacksonville, Florida, along with available corresponding surgical diagnoses...
February 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28110453/update-on-the-diagnosis-and-treatment-of-cholangiocarcinoma
#2
REVIEW
Bryan Doherty, Vinod E Nambudiri, William C Palmer
PURPOSE OF REVIEW: Cholangiocarcinoma is a rare biliary adenocarcinoma associated with poor outcomes. Cholangiocarcinoma is subdivided into extrahepatic and intrahepatic variants. Intrahepatic cholangiocarcinoma is then further differentiated into (1) peripheral mass-forming tumors and (2) central periductal infiltrating tumors. We aimed to review the currently known risk factors, diagnostic tools, and treatment options, as well as highlight the need for further clinical trials and research to improve overall survival rates...
January 2017: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/28110049/performance-of-microscopic-observation-drug-susceptibility-for-the-rapid-diagnosis-of-tuberculosis-and-detection-of-drug-resistance-in-bamako-mali
#3
Moumine Sanogo, Bourahima Kone, Bassirou Diarra, Mamoudou Maiga, Bocar Baya, Anou M Somboro, Yeya S Sarro, Antieme C G Togo, Bindongo P P Dembele, Drissa Goita, Amadou Kone, Ousmane M'Baye, Nadie Coulibaly, Seydou Diabate, Brehima Traore, Mariam H Diallo, Yaya I Coulibaly, Paul Saleeb, Michael Belson, Susan Orsega, Sophia Siddiqui, Michael A Polis, Sounkalo Dao, Robert L Murphy, Souleymane Diallo
OBJECTIVES: In Mali early detection and treatment of multidrug resistance tuberculosis (MDR-TB) are still challenging due to cost, time and/or complexity associated with regular tests. Microscopic Observation Drug Susceptibility (MODS) is a low-cost assay validated by WHO in 2010. It is a liquid culture based assay to detect the "cording" characteristic of Mycobacterium tuberculosis complex (MTBc) and to assess susceptibility to both isoniazid and rifampicin defining MDR-TB. In this study we aimed to evaluate the performance of MODS as diagnostic tool compared to a validated method, the MGIT/AST/SIRE...
January 18, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28109742/development-of-a-new-uplc-esi-ms-ms-method-for-the-determination-of-biopterin-and-neopterin-in-dried-blood-spot
#4
Silvia Santagata, Emanuele Di Carlo, Carla Carducci, Vincenzo Leuzzi, Antonio Angeloni, Claudia Carducci
BACKGROUND: (6R)-5,6,7,8-tetrahydrobiopterin (BH4) deficiencies are rare inherited defects of synthesis or regeneration of BH4. Due to the resulting hyperphenylalaninemia (HPA), some of them are detectedby newborn screening and require the assessment of the pattern of neopterin (Neo) and biopterin (Bio) excretion in urine to be confirmed. Aim of presentstudy was to develop a method for the measurement of these diagnostic biomarkers in dried blood spot (DBS). METHODS: After DBS extraction, samples were filtered and injected into the UPLC column coupled with atandem mass spectrometer working in positive electrospray ionization...
January 18, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28109703/investigation-of-anogenital-distance-as-a-diagnostic-tool-in-endometriosis
#5
Maria L Sánchez-Ferrer, Jaime Mendiola, Raquel Jiménez-Velázquez, Laura Cánovas-López, Shiana Corbalán-Biyang, Ana I Hernández-Peñalver, Ana Carmona-Barnosi, Ana B Maldonado-Cárceles, Maria T Prieto-Sánchez, Francisco Machado-Linde, Anibal Nieto, Alberto M Torres-Cantero
An association between anogenital distance (AGD) and endometriosis has been reported, suggesting that AGD may be a useful clinical tool in endometriosis. The predictive ability of AGD of women in discriminating presence and type of endometriosis was examined. A case-control study was conducted at the University Hospital 'Virgen de la Arrixaca', Murcia, Spain, between 2014 and 2015. A total of 114 participants diagnosed with endometriosis using ultrasound findings and 105 controls were recruited. Two AGD measurements were obtained: one from the anterior clitoral surface to the upper verge of the anus (AGDAC), and another one from the posterior fourchette to the upper verge of the anus (AGDAF)...
January 10, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28109430/reannotation-of-genomes-by-means-of-proteomics-data
#6
J Armengaud
Omics approaches have become popular in biology as powerful discovery tools, and currently gain in interest for diagnostic applications. Establishing the accurate genome sequence of any organism is easy, but the outcome of its annotation by means of automatic pipelines remains imprecise. Some protein-encoding genes may be missed as soon as they are specific and poorly conserved in a given taxon, while important to explain the specific traits of the organism. Translational starts are also poorly predicted in a relatively important number of cases, thus impacting the protein sequence database used in proteomics, comparative genomics, and systems biology...
2017: Methods in Enzymology
https://www.readbyqxmd.com/read/28109406/salivary-biomarkers-in-the-diagnosis-of-breast-cancer-a-review
#7
REVIEW
Elisa Cançado Porto-Mascarenhas, Daniele Xavier Assad, Hélène Chardin, David Gozal, Graziela De Luca Canto, Ana Carolina Acevedo, Eliete Neves Silva Guerra
Salivary biomarkers could be helpful to characterize breast cancer. Therefore, this review was performed to evaluate the capability of salivary biological markers in the diagnosis and monitoring of breast cancer. Studies were eligible for inclusion if they assessed the potential diagnostic value or other discriminatory properties of biological markers in saliva of patients with breast cancer. The search was performed in six electronic databases (Cochrane, LILACS, PubMed, Science Direct, Scopus, Web of Science)...
February 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28109293/genetic-instability-and-increased-mutational-load-which-diagnostic-tool-best-direct-patients-with-cancer-to-immunotherapy
#8
Giuseppe Palmieri, Maria Colombino, Antonio Cossu, Antonio Marchetti, Gerardo Botti, Paolo A Ascierto
The occurrence of high rates of somatic mutations in cancer is believed to correspond to increased frequency of neo-epitope formation and tumor immunogenicity. Thus, classification of patients with cancer according to degree a somatic hyper-mutational status could be proposed as a predictive biomarker of responsiveness to immunotherapy with immune checkpoint inhibitors. Here, we discuss the suitable and reliable tests easily adoptable in clinical practice to assess somatic mutational status in patients with advanced cancer...
January 21, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28109027/amplitude-integrated-electroencephalography-can-predict-neurodevelopmental-outcome-at-12-months-of-corrected-age-in-very-preterm-infants
#9
Elisabeth Ralser, Vera Neubauer, Ulrike Pupp-Peglow, Ursula Kiechl-Kohlendorfer, Elke Griesmaier
AIM: It is difficult to find diagnostic tools than can reliably predict neurodevelopmental outcomes in very preterm infants in clinical practice. This study evaluated whether amplitude-integrated electroencephalography predicted neurodevelopmental outcome in preterm infants when they reached 12 months of corrected age. METHODS: Between October 2007 and December 2013 we studied 232 preterm infants (51% male) at Innsbruck Medical University Hospital, Austria. Their mean birth weight was 1,264 grams and their mean gestational age was 29...
January 20, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28108854/elective-icp-monitoring-how-long-is-long-enough
#10
S D Thompson, A Coutts, C L Craven, A K Toma, L W Thorne, L D Watkins
BACKGROUND: Intracranial pressure monitoring is commonly undertaken to assess and manage acute patients following head injury. However, ICP monitoring can also be a useful diagnostic tool in the management of CSF dynamics in elective patients. To date, there is little published research to suggest how long these elective patients require ICP monitoring in order to gain an accurate picture of a patient's ICP dynamics. At the author's institution, a minimum of 48-h data collection is currently undertaken in patients with a suspected ICP abnormality...
January 20, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28107883/batch-medication-of-intestinal-infections-in-nursery-pigs-a-randomised-clinical-trial-on-the-efficacy-of-treatment-strategy-type-of-antibiotic-and-bacterial-load-on-average-daily-weight-gain
#11
Nicolai Rosager Weber, Ken Steen Pedersen, Christian Fink Hansen, Matthew Denwood, Charlotte Kristiane Hjulsager, Jens Peter Nielsen
INTRODUCTION: Previous research projects have demonstrated the need for better diagnostic tools to support decisions on medication strategies for infections caused by Escherichia coli F4 (F4) and F18 (F18), Lawsonia intracellularis (LI) and Brachyspira pilosicoli (PILO). This study was carried out as a randomised clinical trial in three Danish pig herds and included 1047 nursery pigs, distributed over 10 batches and 78 pens. The objectives of this study were: (1) to assess the effect of four 5-day treatment strategies (initiated at clinical outbreak of diarrhoea or at fixed time points 14, 21, or 28days after weaning) on average daily weight gain (ADG); (2) to compare the effect of treatment with doxycycline or tylosine on diarrhoea prevalence, pathogenic bacterial load, and ADG; (3) to evaluate PCR testing of faecal pen floor samples as a diagnostic tool for determining the optimal time of treatment...
February 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28107881/a-census-to-determine-the-prevalence-and-risk-factors-for-caprine-arthritis-encephalitis-virus-and-visna-maedi-virus-in-the-swiss-goat-population
#12
B Thomann, L C Falzon, G Bertoni, H R Vogt, G Schüpbach-Regula, I Magouras
In Switzerland, viruses belonging to two different phylogenetic groups of small ruminant lentiviruses (SRLV) are currently circulating: the caprine arthritis-encephalitis virus (CAEV) and visna/maedi virus (VMV). In the past two decades, a mandatory national control program has led to a very low prevalence of seropositivity, while completely eliminating CAE as a clinical manifestation. However, in order to reduce the high costs and effort associated with this program, adjustments based on the most recent epidemiological knowledge are needed...
February 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28107787/hiv-rapid-testing-in-the-framework-of-an-sti-prevention-project-on-a-cohort-of-vulnerable-italians-and-immigrants
#13
Ilaria Uccella, Alessio Petrelli, Maria Fenicia Vescio, Silvia De Carolis, Cecilia Fazioli, Patrizio Pezzotti, Gianni Rezza
INTRODUCTION: Uptake of HIV tests is a challenging issue in vulnerable populations including immigrants, normally using standard diagnostic tools. Objectives of this study were to evaluate the acceptability of HIV rapid test; estimate the percentage of newly HIV diagnoses and evaluate knowledge, attitudes and perception (KAP) about HIV/AIDS and other STIs in a specific set of immigrants and vulnerable population in Rome (Italy). METHODS: All immigrant and Italian people, aged 16-70 years, attending the infectious disease outpatient clinic of the National Institute for Health, Migration and Poverty (INMP) in Rome (Italy), during the period December 2012 to December 2013 were enrolled...
January 20, 2017: AIDS Care
https://www.readbyqxmd.com/read/28107565/idermatopath-a-novel-software-tool-for-mitosis-detection-in-h-e-stained-tissue-sections-of-malignant-melanoma
#14
C Andres, B Andres-Belloni, R Hein, T Biedermann, A Schäpe, N Brieu, R Schönmeyer, M Yigitsoy, J Ring, G Schmidt, N Harder
BACKGROUND: Malignant Melanoma (MM) is characterized by a growing incidence and a high malignant potential. Beside well defined prognostic factors such as tumor thickness and ulceration, the Mitotic Rate (MR) was included in the AJCC recommendations for diagnosis and treatment of MM. In daily routine, the identification of a single mitosis can be difficult on Hematoxylin&Eosin slides alone. Several studies showed a big inter- and intra-individual variability in detecting the MR in MM even by very experienced investigators, thus raising the question for a computer assisted method...
January 20, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28107413/improving-the-conservation-of-mediterranean-chondrichthyans-the-elasmomed-dna-barcode-reference-library
#15
Alessia Cariani, Silvia Messinetti, Alice Ferrari, Marco Arculeo, Juan J Bonello, Leanne Bonnici, Rita Cannas, Pierluigi Carbonara, Alessandro Cau, Charis Charilaou, Najib El Ouamari, Fabio Fiorentino, Maria Cristina Follesa, Germana Garofalo, Daniel Golani, Ilaria Guarniero, Robert Hanner, Farid Hemida, Omar Kada, Sabrina Lo Brutto, Cecilia Mancusi, Gabriel Morey, Patrick J Schembri, Fabrizio Serena, Letizia Sion, Marco Stagioni, Angelo Tursi, Nedo Vrgoc, Dirk Steinke, Fausto Tinti
Cartilaginous fish are particularly vulnerable to anthropogenic stressors and environmental change because of their K-selected reproductive strategy. Accurate data from scientific surveys and landings are essential to assess conservation status and to develop robust protection and management plans. Currently available data are often incomplete or incorrect as a result of inaccurate species identifications, due to a high level of morphological stasis, especially among closely related taxa. Moreover, several diagnostic characters clearly visible in adult specimens are less evident in juveniles...
2017: PloS One
https://www.readbyqxmd.com/read/28107119/olfaction-new-understandings-diagnostic-applications
#16
Gabrielle F Ruggiero, Jeannette Y Wick
Estimates indicate that 14 million Americans have olfactory dysfunction. As with other senses, such as sight and hearing, olfaction frequently declines with age. Impaired olfaction can be a warning sign of Parkinson's disease, sometimes occurring before motor symptoms develop. It's also an initial symptom of Alzheimer's dementia (AD); the amyloid plaques and tangles characterizing AD invade the olfactory bulb and hippocampus early in its course, hampering odor identification. Olfactory dysfunction is associated with some serious problems, including inability to smell warning odors (fire, gas) and impaired ability to taste food...
November 1, 2016: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/28106612/the-brief-early-childhood-screening-assessment-preliminary-validity-in-pediatric-primary-care
#17
Elise M Fallucco, Tim Wysocki, Lauren James, Chelsea Kozikowski, Andre Williams, Mary M Gleason
OBJECTIVE: Brief, well-validated instruments are needed to facilitate screening for early childhood behavioral and emotional problems (BEPs). The objectives of this study were to empirically reduce the length of the Early Childhood Screening Assessment (ECSA) and to assess the validity and reliability of this shorter tool. METHODS: Using caregiver ECSA responses for 2467 children aged 36 to 60 months seen in primary care, individual ECSA items were ranked on a scale ranging from "absolutely retain" to "absolutely delete...
January 17, 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28106282/prediction-of-pan-specific-b-cell-epitopes-from-nucleocapsid-protein-of-hantaviruses-causing-hantavirus-cardiopulmonary-syndrome
#18
Sagadevan Kalaiselvan, Sathish Sankar, Mageshbabu Ramamurthy, Asit Ranjan Ghosh, Balaji Nandagopal, Gopalan Sridharan
Hantaviruses are emerging viral pathogens that causes hantavirus cardiopulmonary syndrome in the Americas (HCPS), a severe, sometimes fatal, respiratory disease in humans with a case fatality rate of ≥50%. IgM and IgG based serological detection methods are the most common approaches used for laboratory diagnosis of hantaviruses. Such emerging viral pathogens emphasizes the need for improved rapid diagnostic devices and vaccines incorporating pan-specific epitopes of genotypes. We predicted linear B-cell epitopes for hantaviruses that are specific to genotypes causing HCPS in humans using in silico prediction servers...
January 20, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28105803/structural-characterization-of-phosphatidylcholines-using-193-nm-ultraviolet-photodissociation-mass-spectrometry
#19
Dustin R Klein, Jennifer S Brodbelt
Advances in mass spectrometry have made it a preferred tool for structural characterization of glycerophospholipids. However, collisional activation methods commonly implemented on commercial instruments do not provide fragmentation patterns that allow elucidation of certain structural features, including acyl chain positions on the glycerol backbone and double bond positions within acyl chains. In the present work, 193 nm ultraviolet photodissociation (UVPD) implemented on an orbitrap mass spectrometer is used to localize double bond positions within phosphatidylcholine (PC) acyl chains...
January 10, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28105681/salmon-gill-poxvirus-a-recently-characterized-infectious-agent-of-multifactorial-gill-disease-in-freshwater-and-seawater-reared-atlantic-salmon
#20
REVIEW
M C Gjessing, E Thoen, T Tengs, S A Skotheim, O B Dale
Gill diseases cause considerable losses in Norwegian salmon farming. In 2015, we characterized salmon gill poxvirus (SGPV) and associated gill disease. Using newly developed diagnostic tools, we show here that SGPV infection is more widely distributed than previously assumed. We present seven cases of complex gill disease in Atlantic salmon farmed in seawater and freshwater from different parts of Norway. Apoptosis, the hallmark of acute SGPV infection, was not easily observed in these cases, and qPCR analysis was critical for identification of the presence of SGPV...
January 20, 2017: Journal of Fish Diseases
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