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https://www.readbyqxmd.com/read/29793170/effective-size-selection-of-mos-2-nanosheets-by-a-novel-liquid-cascade-centrifugation-influences-of-the-flakes-dimensions-on-electrochemical-and-photoelectrochemical-applications
#1
Marzieh Kajbafvala, Mansoor Farbod
Although liquid phase exfoliation is a powerful method to produce MoS2 nanosheets in large scale, but its effectiveness is limited by the diversity of produced nanosheets sizes. Here a novel approach for separation of MoS2 flakes having various lateral sizes and thicknesses based on the cascaded centrifugation has been introduced. This method involves a pre-separation step which is performed through low-speed centrifugation to avoid the deposition of large area single and few-layers by the heavier particles...
May 14, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29793031/cloning-overexpression-and-purification-of-a-gene-of-unknown-function-of-prophage-loci-from-candidatus-liberibacter-asiaticus-the-destructive-bacterial-pathogen-of-huanglongbing-disease-in-citrus-plants
#2
Duangtip Sudhan, Thamrongjet Puttamuk, Supachai Vuttipongchaikij, Pitak Chuawong
Citrus Huanglongbing (HLB) or citrus greening is one of the most destructive diseases affecting citrus industry worldwide. The causal agent in Asia is a phloem-limited, Gram-negative bacterium, 'Candidatus Liberibacter asiaticus' (CLas). Within the genome of CLas lies prophage regions, classified as Type-A, B, C, and D. In particular, Type-D has been indicated to correlate with the blotchy-mottle symptoms of citrus trees. Here we reported the cloning, overexpression, and purification of the ORF1, an open reading frame from the partial Type-D region of CLas obtained from an infected lime tree (Citrus aurantifolia Swingle)...
May 21, 2018: Protein Expression and Purification
https://www.readbyqxmd.com/read/29792897/mathematical-modeling-and-numerical-simulation-of-the-mitotic-spindle-orientation-system
#3
Bashar Ibrahim
The mitotic spindle orientation and position is crucial for the fidelity of chromosome segregation during asymmetric cell division to generate daughter cells with different sizes or fates. This mechanism is best understood in the budding yeast Saccharomyces cerevisiae, named the spindle position checkpoint (SPOC). The SPOC inhibits cells from exiting mitosis until the mitotic spindle is properly oriented along the mother-daughter polarity axis. Despite many experimental studies, the mechanisms underlying SPOC regulation remains elusive and unexplored theoretically...
May 21, 2018: Mathematical Biosciences
https://www.readbyqxmd.com/read/29792689/selectivity-within-a-family-of-bacterial-phosphothreonine-lyases
#4
Kaitlin A Chambers, Nile S Abularrage, Rebecca A Scheck
Phosphothreonine lyases are bacterial effector proteins secreted into host cells to facilitate the infection process. This enzyme family catalyzes an irreversible elimination reaction that converts phosphothreonine or phosphoserine to dehydrobutyrine or dehydroalanine, respectively. Herein we report a study of substrate selectivity for each of the four known phosphothreonine lyases. This was accomplished using a combination of mass spectrometry and enzyme kinetics assays for a series of phosphorylated peptides derived from the mitogen activated protein kinase (MAPK) activation loop...
May 24, 2018: Biochemistry
https://www.readbyqxmd.com/read/29792395/how-are-patients-with-heart-failure-treated-in-primary-care
#5
Hélène Vaillant-Roussel, Bruno Pereira, Sylvaine Gibot-Boeuf, Romain Eschalier, Claude Dubray, Rémy Boussageon, Philippe Vorilhon
OBJECTIVE: The aim of this study was to assess the adherence of general practitioners (GPs) to guidelines in patients with heart failure with reduced ejection fraction (HFrEF) and to describe GPs' prescribing behavior regarding patients with heart failure with preserved ejection fraction (HFpEF). MATERIALS AND METHODS: Cross-sectional study as part of the ETIC trial. Five classes of drugs were described: angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs); β-blockers (BBs); mineralocorticoid receptor antagonists (MRAs); diuretics (thiazide or loop diuretics); and digoxin...
May 24, 2018: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29791683/the-t-loop-in-details
#6
Amanda Frizzo Viecilli, Maria Perpétua Mota Freitas
INTRODUCTION: The T-loop as designed by Burstone is a space closure spring used in the rational application of orthodontic biomechanics. Despite the diversity of studies, there is still no consensus on the optimal parametric characteristics for its conformation. OBJECTIVE: This study aimed at reviewing the literature on the force systems released by different conformations of the T-loop, according to the type of anchorage and the main characteristics and factors that influence them...
January 2018: Dental Press Journal of Orthodontics
https://www.readbyqxmd.com/read/29791497/xenin-is-a-novel-anorexigen-in-goldfish-carassius-auratus
#7
Brent Kerbel, Kimberly Badal, Lakshminarasimhan Sundarrajan, Ayelen Blanco, Suraj Unniappan
Xenin, a highly conserved 25 amino acid peptide cleaved from the N-terminus of the coatomer protein alpha (COPA), is emerging as a food intake regulator in mammals and birds. To date, no research has been conducted on xenin biology in fish. This study aims to identify the copa mRNA encoding xenin in goldfish (Carassius auratus) as a model, to elucidate its regulation by feeding, and to describe the role of xenin on appetite. First, a partial sequence of copa cDNA, a region encoding xenin, was identified from goldfish brain...
2018: PloS One
https://www.readbyqxmd.com/read/29791483/structural-study-reveals-the-temperature-dependent-conformational-flexibility-of-tk-ptp-a-protein-tyrosine-phosphatase-from-thermococcus-kodakaraensis-kod1
#8
Hye-Yeoung Yun, Jinhyuk Lee, Hyunmin Kim, Hyojung Ryu, Ho-Chul Shin, Byung-Ha Oh, Bonsu Ku, Seung Jun Kim
Protein tyrosine phosphatases (PTPs) originating from eukaryotes or bacteria have been under intensive structural and biochemical investigation, whereas archaeal PTP proteins have not been investigated extensively; therefore, they are poorly understood. Here, we present the crystal structures of Tk-PTP derived from the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1, in both the active and inactive forms. Tk-PTP adopts a common dual-specificity phosphatase (DUSP) fold, but it undergoes an atypical temperature-dependent conformational change in its P-loop and α4-α5 loop regions, switching between the inactive and active forms...
2018: PloS One
https://www.readbyqxmd.com/read/29791340/design-of-a-delayed-xor-phase-detector-for-an-optical-phase-locked-loop-toward-high-speed-coherent-laser-communication
#9
Yang Liu, Shoufeng Tong, Shuai Chang, Yansong Song, Yan Dong, Xin Zhao, Zhe An, Fuwan Yu
Optical phase-locked loops are an effective detection method in high-speed and long-distance laser communication. Although this method can detect weak signal light and maintain a small bit error rate, it is difficult to perform because identifying the phase difference between the signal light and the local oscillator accurately has always been a technical challenge. Thus, a series of studies is conducted to address this issue. First, a delayed exclusive or gate (XOR) phase detector with multi-level loop compound control is proposed...
May 10, 2018: Applied Optics
https://www.readbyqxmd.com/read/29791324/unimorph-mirror-for-adaptive-optics-in-space-telescopes
#10
David Alaluf, Renaud Bastaits, Kainan Wang, Mihaita Horodinca, Grégory Martic, Bilal Mokrani, André Preumont
This paper presents a unimorph deformable mirror intended to be used as secondary corrector in space telescopes. The deformable mirror consists of a single-crystal silicon wafer (76.2 mm diameter, 500 μm thickness) covered with an optical coating on the front side and an array of 25 independent piezoelectric transducer (PZT) actuators acting in d31 mode on the back side. The mirror is mounted on an isostatic support with three position linear actuators controlling the rigid-body motion. The first part of the paper presents the experimental results obtained with the manufactured prototype...
May 10, 2018: Applied Optics
https://www.readbyqxmd.com/read/29791295/ultrasonographic-detection-of-ingested-fishing-lines-in-loggerheads-caretta-caretta
#11
Delia Franchini, Carmela Valastro, Stefano Ciccarelli, Francesco Caprio, Diana Lenoci, Antonio Di Bello
Loggerhead sea turtles ( Caretta caretta) are among the most frequent victims of bycatch in drifting longlines, and the ingestion of fish hooks and fishing lines is one of the most frequent causes of death of sea turtles. The aim of this study was to evaluate whether coelomic ultrasound (US) can be decisive, not only for diagnosis but also to optimize surgical planning based on preoperative evaluation of the bowel conditions and, in addition, to see if there are characteristic sonographic findings in sea turtles associated with the ingestion of fishing lines...
May 23, 2018: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/29790986/monitoring-substrate-enables-real-time-regulation-of-a-protein-localization-pathway
#12
Koreaki Ito, Hiroyuki Mori, Shinobu Chiba
Protein localization machinery supports cell survival and physiology, suggesting the potential importance of its expression regulation. Here, we summarize a remarkable scheme of regulation, which allows real-time feedback regulation of the machinery expression. A class of regulatory nascent polypeptides, called monitoring substrates, undergoes force-sensitive translation arrest. The resulting ribosome stalling on the mRNA then affects mRNA folding to expose the ribosome-binding site of the downstream target gene and upregulate its translation...
June 1, 2018: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/29790963/the-presenilin-loop-region-is-essential-for-glycogen-synthase-kinase-3-beta-mediated-functions-on-motor-proteins-during-axonal-transport
#13
Rupkatha Banerjee, Zoe Rudloff, Crystal Naylor, Michael Yu, Shermali Gunawardena
Neurons require intracellular transport of essential components for function and viability, and defects in transport has been implicated in many neurodegenerative diseases including Alzheimer's disease (AD). One possible mechanism by which transport defects could occur is by improper regulation of molecular motors. Previous work showed that reduction of Presenilin (PS) or Glycogen synthase kinase 3 beta (GSK3β) stimulated APP vesicle motility. Excess GSK3β caused transport defects and increased motor binding to membranes, while reduction of PS decreased active GSK3β and motor binding to membranes...
May 22, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29790232/rapid-photo-actuation-of-a-dna-nanostructure-using-an-internal-photocaged-trigger-strand
#14
Nicholas Stephanopoulos, Minghui Liu, Shuoxing Jiang, Omar Loza, Petr Šulc, Nour Eddine Fahmi
We describe a reconfigurable DNA nano-tweezer that can be switched between a close and open state with a brief pulse of UV light. In its initial state, the tweezer is held shut using a hairpin with a single-stranded poly-A loop. Also incorporated in the structure is a poly-T trigger strand bearing seven photocaged residues. Upon illumination with 365 nm light, the cages are removed and the trigger strand hybridizes to the loop, opening the tweezer and increasing the distance between its arms from 4 to 18 nm...
May 23, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29790128/evidence-that-the-length-of-bile-loop-determines-serum-bile-acid-concentration-and-glycemic-control-after-bariatric-surgery
#15
Adriana Mika, Lukasz Kaska, Monika Proczko-Stepaniak, Agnieszka Chomiczewska, Julian Swierczynski, Ryszard T Smolenski, Tomasz Sledzinski
BACKGROUND: Bariatric surgery contributes to the improvement in glucose metabolism that may be related to a postoperative increase in serum bile acids (BAs). Three commonly used types of bariatric procedures, laparoscopic sleeve gastrectomy (LSG) (without creation of a bile loop), Roux-en-Y gastric bypass (RYGB), and omega-loop gastric bypass (OLGB) (with creation of shorter 100-150 cm and longer 200-280 cm bile loops, respectively), differ in their effects on glycemic control. The aim of the study was to compare the effects of various bariatric procedures on serum BA concentration and glucose homeostasis...
May 22, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29789846/macroscopic-and-local-approaches-of-phase-transition-in-sol-gel-synthesized-bi-0-5-na-0-5-tio-3-srtio-3-thin-films
#16
Hyun-Young Lee, Jin Luo, Zhen Zhou, Wei Sun, Jing-Feng Li
High-quality (1 - x)(Bi0.5Na0.5)TiO3-xSrTiO3 lead-free piezoelectric thin films (x = 0, 0.1, and 0.25) on Pt(111)/Ti/SiO2/Si(100) substrates were prepared by a sol-gel method. The microstructures of the thin films as a function of SrTiO3 doping level and temperature were investigated by X-ray diffraction and Raman spectroscopy. Their temperature- and frequency-dependent piezoelectric properties were studied on the nanoscale using switching spectroscopy piezoresponse force microscopy (SS-PFM). A rhombohedral ferroelectric to pseudocubic relaxor phase transition was observed when either ST content or temperature increased...
May 23, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29789823/influenza-a-m2-transmembrane-domain-tunes-its-conformational-heterogeneity-and-structural-plasticity-in-the-lipid-bilayer-by-forming-loop-structures
#17
Yue Liu, Junjun Tan, Jiahui Zhang, Chuanzhao Li, Yi Luo, Shuji Ye
We discovered for the first time that the influenza A virus M2TM tunes its conformational heterogeneity and structural plasticity to respond to environmental cues by undergoing a helix-to-loop transition, resolving controversies regarding the mechanism of proton conduction and plasticity of the M2TM in lipid bilayers.
May 23, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29789521/triad3a-induces-the-degradation-of-early-necrosome-to-limit-ripk1-dependent-cytokine-production-and-necroptosis
#18
Norah A Alturki, Scott McComb, Ardeshir Ariana, Dikchha Rijal, Robert G Korneluk, Shao-Cong Sun, Emad Alnemri, Subash Sad
Understanding the molecular signaling in programmed cell death is vital to a practical understanding of inflammation and immune cell function. Here we identify a previously unrecognized mechanism that functions to downregulate the necrosome, a central signaling complex involved in inflammation and necroptosis. We show that RipK1 associates with RipK3 in an early necrosome, independent of RipK3 phosphorylation and MLKL-induced necroptotic death. We find that formation of the early necrosome activates K48-ubiquitin-dependent proteasomal degradation of RipK1, Caspase-8, and other necrosomal proteins...
May 22, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29789378/subthalamic-nucleus-neurons-differentially-encode-early-and-late-aspects-of-speech-production
#19
W J Lipski, A Alhourani, T Pirnia, P W Jones, C Dastolfo-Hromack, L B Helou, D J Crammond, S Shaiman, M W Dickey, L L Holt, R S Turner, J A Fiez, R M Richardson
Basal ganglia-thalamocortical loops mediate all motor behavior, yet little detail is known about the role of basal ganglia nuclei in speech production. Using intracranial recording during deep brain stimulation surgery in humans with Parkinson's disease, we tested the hypothesis that the firing rate of subthalamic nucleus neurons is modulated in sync with motor execution aspects of speech. Nearly half of seventy-nine unit recordings exhibited firing rate modulation, during a syllable reading task across twelve subjects (male and female)...
May 22, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29788989/loop-ostomy-following-laparoscopic-low-anterior-resection-for-rectal-cancer-after-neoadjuvant-chemoradiotherapy
#20
Xin Wu, Guole Lin, Huizhong Qiu, Yi Xiao, Bin Wu, Miner Zhong
BACKGROUND: Both loop ileostomy (LI) and loop transverse colostomy (LTC) could achieve absolute fecal diversion and have several advantages. This study compared LI and LTC following laparoscopic low anterior resection for rectal cancer after neoadjuvant chemoradiotherapy. METHODS: Between January 2009 and December 2016, 186 patients who underwent laparoscopic low anterior resection for rectal cancer and loop ostomy were included. All patients received preoperative neoadjuvant chemoradiotherapy...
May 22, 2018: European Journal of Medical Research
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