keyword
MENU ▼
Read by QxMD icon Read
search

Stroke ischemia reperfusion

keyword
https://www.readbyqxmd.com/read/28226875/dihydrocapsaicin-induced-hypothermia-after-asphyxiai-cardiac-arrest-in-rats
#1
Junyun He, Leanne Young, Xiaofeng Jia, Junyun He, Leanne Young, Xiaofeng Jia, Xiaofeng Jia, Leanne Young, Junyun He
Cardiac arrest (CA) is one of the leading causes of mortality and morbidity in the world. Fast, reversible and controllable pharmaceutical-induced hypothermia (PIH) is strongly desired to treat ischemia-reperfusion brain injury. Dihydrocapsaicin (DHC), an agonist of transient receptor potential vanilloid type 1 cation channel (TRPV1), is an emerging candidate for PIH. Its capability to lower body temperature has been validated in both healthy and stroke animal models. However, DHC has shown cardiovascular effects and its safety and feasibility in a CA model has not been tested...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28217292/oxygen-or-cooling-to-make-a-decision-after-acute-ischemia-stroke
#2
REVIEW
Wen-Cao Liu, Xin-Chun Jin
The presence of a salvageable penumbra, a region of ischemic brain tissue with sufficient energy for short-term survival, has been widely agreed as the premise for thrombolytic therapy with tissue plasminogen activator (tPA), which remains the only United States Food and Drug Administration (FDA) approved treatment for acute ischemia stroke. However, the use of tPA has been profoundly constrained due to its narrow therapeutic time window and the increased risk of potentially deadly hemorrhagic transformation (HT)...
October 2016: Medical Gas Research
https://www.readbyqxmd.com/read/28210876/effect-of-hyperhomocysteinemia-on-redox-balance-and-redox-defence-enzymes-in-ischemia-reperfusion-injury-and-or-after-ischemic-preconditioning-in-rats
#3
Martin Petráš, Anna Drgová, Mária Kovalská, Zuzana Tatarková, Barbara Tóthová, Oľga Križanová, Ján Lehotský
Increased level of homocysteine (hHcy) in plasma is an accompanying phenomenon of many diseases, including a brain stroke. This study determines whether hyperhomocysteinemia (which is a risk factor of brain ischemia) itself or in combination with ischemic preconditioning affects the ischemia-induced neurodegenerative changes, generation of reactive oxygen species (ROS), lipoperoxidation, protein oxidation, and activity of antioxidant enzymes in the rat brain cortex. The hHcy was induced by subcutaneous administration of homocysteine (0...
February 16, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/28203483/galanin-protects-from-caspase-8-12-initiated-neuronal-apoptosis-in-the-ischemic-mouse-brain-via-galr1
#4
Yun Li, Zhu Mei, Shuiqiao Liu, Tong Wang, Hui Li, Xiao-Xiao Li, Song Han, Yutao Yang, Junfa Li, Zhi-Qing David Xu
Galanin (GAL) plays key role in many pathophysiological processes, but its role in ischemic stroke remains unclear. Here, the models of 1 h middle cerebral artery occlusion (MCAO)/1-7 d reperfusion (R)-induced ischemic stroke and in vitro cell ischemia of 1 h oxygen-glucose deprivation (OGD)/24 h reoxygenation in primary cultured cortical neurons were used to explore GAL's effects and its underlying mechanisms. The results showed significant increases of GAL protein levels in the peri-infarct region (P) and infarct core (I) within 48 h R of MCAO mice (p<0...
February 2017: Aging and Disease
https://www.readbyqxmd.com/read/28203482/long-non-coding-rna-h19-induces-cerebral-ischemia-reperfusion-injury-via-activation-of-autophagy
#5
Jue Wang, Bin Cao, Dong Han, Miao Sun, Juan Feng
Long non-coding RNA H19 (lncRNA H19) was found to be upregulated by hypoxia, its expression and function have never been tested in cerebral ischemia and reperfusion (I/R) injury. This study intended to investigate the role of lncRNA H19 and H19 gene variation in cerebral I/R injury with focusing on its relationship with autophagy activation. Cerebral I/R was induced in rats by middle cerebral artery occlusion followed by reperfusion. SH-SY5Y cells were subjected to oxygen and glucose deprivation and reperfusion (OGD/R) to simulate I/R injury...
February 2017: Aging and Disease
https://www.readbyqxmd.com/read/28202285/decreased-mir-146a-expression-in-acute-ischemic-stroke-directly-targets-the-fbxl10-mrna-and-is-involved-in-modulating-apoptosis
#6
Sheng-Hua Li, Lan Chen, Xiao-Min Pang, Sheng-You Su, Xia Zhou, Chun-Yong Chen, Li-Gang Huang, Jing-Pin Li, Jing-Li Liu
BACKGROUND: miR-146a, a strong pro-apoptotic factor in some pathophysiological processes, is reported to be involved in ischemic stroke (IS), though its role remains unclear. Fbxl10 is an active anti-apoptotic factor and a predicted target of miR-146a. We hypothesized that dysregulation of miR-146a contributes to ischemic injury by targeting Fbxl10. METHODS: Circulating miRNAs were detected by miRNA microarray and qRT-PCR. miR-146a targets were predicted using bioinformatics and confirmed with a dual luciferase reporter assay...
February 12, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28202057/improvement-of-memory-and-learning-by-intracerebroventricular-microinjection-of-t3-in-rat-model-of-ischemic-brain-stroke-mediated-by-upregulation-of-bdnf-and-gdnf-in-ca1-hippocampal-region
#7
Tahmineh Mokhtari, Mohammad Akbari, Fatemeh Malek, Iraj Ragerdi Kashani, Tayebeh Rastegar, Farshid Noorbakhsh, Mahmoud Ghazi-Khansari, Fatemeh Attari, Gholamreza Hassanzadeh
BACKGROUND: Ischemic stroke is a common leading cause of death and disability with lack of effective therapies. In this study, T3 was intra-ventricularly injected to evaluate gene expression and protein concentration of and brain-derived neurotrophic factor (BDNF) and Glial cell-derived neurotrophic factor (GDNF) in hippocampal CA1 region in rat model of brain ischemia/reperfusion (I/R). METHODS: In this study, transient middle cerebral artery occlusion (tMCAo) was used as model of ischemic brain stroke...
February 15, 2017: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/28193834/genome-wide-analysis-of-the-circulating-mirnome-after-cerebral-ischemia-reveals-a-reperfusion-induced-microrna-cluster
#8
Stefan Uhlmann, Eva Mracsko, Ehsan Javidi, Sarah Lamble, Ana Teixeira, Agnes Hotz-Wagenblatt, Karl-Heinz Glatting, Roland Veltkamp
BACKGROUND AND PURPOSE: Circulating microRNAs (miRNAs) are emerging biomarkers for stroke because of their high stability in the bloodstream and association with pathophysiologic conditions. However, the circulating whole-genome miRNAs (miRNome) has not been characterized comprehensively in the acute phase of stroke. METHODS: We profiled the circulating miRNome in mouse models of acute ischemic and hemorrhagic stroke by next-generation sequencing. Stroke models were compared with sham-operated and naive mice to identify deregulated circulating miRNAs...
February 13, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28192099/role-of-interleukin-10-in-the-neuroprotective-effect-of-the-angiotensin-type-2-receptor-agonist-compound-21-after-ischemia-reperfusion-injury
#9
Abdelrahman Y Fouda, Bindu Pillai, Krishnan M Dhandapani, Adviye Ergul, Susan C Fagan
INTRODUCTION: We and others have shown that the angiotensin type 2 (AT2) receptor agonist, compound 21 (C21), provides neuroprotection and enhances recovery in rodent stroke models yet the mechanism involved is not known. Moreover, C21 treatment is associated with an anti-inflammatory response. Here we tested the hypothesis that C21 mediates neuroprotection by upregulating the neuroprotective and anti-inflammatory cytokine, interleukin (IL)-10. METHODS: Wistar rats were subjected to 3h-middle cerebral artery suture occlusion and treated at reperfusion with C21 (0...
February 10, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28191863/ulinastatin-downregulates-tlr4-and-nf-kb-expression-and-protects-mouse-brains-against-ischemia-reperfusion-injury
#10
Xiaofang Li, Likai Su, Xiangjian Zhang, Cong Zhang, Lina Wang, Yaoru Li, Ye Zhang, Tingting He, Xingyuan Zhu, Lili Cui
BACKGROUND: Inflammatory damage plays an important role in ischemic stroke and provides potential targets for therapy. Ulinastatin (UTI), a drug used to treat shock and acute pancreatitis in clinic, has attracted attention for its protective effects through immunomodulatory and anti-inflammatory properties. However, the effect of UTI in the acute phase of cerebral ischemia/reperfusion (I/R) is not clear. This study is to investigate the potential neuroprotective effect of UTI and explore its underlying mechanisms...
February 13, 2017: Neurological Research
https://www.readbyqxmd.com/read/28186440/britanin-ameliorates-cerebral-ischemia-reperfusion-injury-by-inducing-the-nrf2-protective-pathway
#11
Guozhen Wu, Lili Zhu, Xing Yuan, Hao Chen, Rui Xiong, Shoude Zhang, Hao Cheng, Yunheng Shen, Huazhang An, Tiejun Li, Honglin Li, Weidong Zhang
AIMS: Oxidative stress is considered the major cause of tissue injury after cerebral ischemia. The nuclear factor erythroid 2-related factor 2 (Nrf2) pathway is one of the most important defensive mechanisms against oxidative stresses and has been confirmed as a target for stroke treatment. Thus, we desired to find new Nrf2 activators and test their neuronal protective activity both in vivo and in vitro. RESULTS: The herb-derived compound Britanin is a potent inducer of the Nrf2 system...
February 10, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28178380/pre-ischemia-melatonin-treatment-alleviated-acute-neuronal-injury-after-ischemic-stroke-by-inhibiting-er-stress-dependent-autophagy-via-perk-and-ire1-signalings
#12
Dayun Feng, Bao Wang, Lei Wang, Neeta Abraham, Kai Tao, Lu Huang, Wei Shi, Yushu Dong, Yan Qu
Melatonin has demonstrated a potential protective effect in central nervous system. Thus, it is interesting to determine whether pre-ischemia melatonin administration could protect against cerebral ischemia/reperfusion (IR) related injury and the underlying molecular mechanisms. In this study, we revealed that IR injury significantly activated endoplasmic reticulum (ER) stress and autophagy in a middle cerebral artery occlusion (MCAO) mouse model. Pre-ischemia melatonin treatment was able to attenuate IR-induced ER stress and autophagy...
February 8, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28176622/the-tlr9-antagonist-icpg-odn-at-different-dosages-inhibits-cerebral-ischemia-reperfusion-injury-in-mice
#13
Ying Zhou, Jingrui Pan, Qingxia Peng, Zhaofei Dong Dong, Lingna Deng Deng, Yidong Wang
Inflammatory responses are important mechanisms that are involved in cerebral ischemia/reperfusion(I/R) injury. Whether toll-like receptor 9(TLR9), which belongs to the innate immune system, takes part in the inflammatory responses following cerebral I/R remains unclear. This study examined the effect of different dosages of the TLR9 antagonist inhibitory oligodeoxynucleotide (iCpG-ODN) on cerebral I/R injury by using a mouse model of transient middle cerebral artery occlusion. Neurological function, infarct size, splenocytes and the expression of TLR9 and the downstream products of the TLR9 pathways were determined after cerebral I/R for up to 72 hours...
February 6, 2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/28162056/tanshinone-%C3%A2-a-elicits-neuroprotective-effect-via-activating-the-nuclear-factor-erythroid-2-related-factor-dependent-antioxidant-response
#14
Min Cai, Yongxin Guo, Shiquan Wang, Haidong Wei, Guangchao Zhao, Sisi Sun, Hailong Dong
Tanshinone ⅡA (TSA), a principal component derived from the Traditional Chinese Medicine Danshen has been suggested to exert neuroprotective effect against experimental cerebral ischemic/reperfusion injury. But the associated underlying mechanisms still have not been understood. The current study characterized the role of nuclear factor erythroid 2-related factor induced antioxidant response in the neuroprotective efficacy of TSA treatment. The focal cerebral ischemia/reperfusion model was established by 60 minutes middle cerebral artery occlusion...
February 4, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28154249/innovations-in-liposomal-dds-technology-and-its-application-for-the-treatment-of-various-diseases
#15
REVIEW
Naoto Oku
Liposomes have been widely used as drug carriers in the field of drug delivery systems (DDS), and they are thought to be ideal nano-capsules for targeting DDS after being injected into the bloodstream. In general, DDS drugs meet the needs of aged and super-aged societies, since the administration route of drugs can be changed, the medication frequency reduced, the adverse effects of drugs suppressed, and so on. In fact, a number of liposomal drugs have been launched and used worldwide including liposomal anticancer drugs, and these drugs have appeared on the market owing to various innovations in liposomal DDS technologies...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28137866/endothelium-targeted-overexpression-of-heat-shock-protein-27-ameliorates-blood-brain-barrier-disruption-after-ischemic-brain-injury
#16
Yejie Shi, Xiaoyan Jiang, Lili Zhang, Hongjian Pu, Xiaoming Hu, Wenting Zhang, Wei Cai, Yanqin Gao, Rehana K Leak, Richard F Keep, Michael V L Bennett, Jun Chen
The damage borne by the endothelial cells (ECs) forming the blood-brain barrier (BBB) during ischemic stroke and other neurological conditions disrupts the structure and function of the neurovascular unit and contributes to poor patient outcomes. We recently reported that structural aberrations in brain microvascular ECs-namely, uncontrolled actin polymerization and subsequent disassembly of junctional proteins, are a possible cause of the early onset BBB breach that arises within 30-60 min of reperfusion after transient focal ischemia...
February 14, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28135002/ischemia-reperfusion
#17
Theodore Kalogeris, Christopher P Baines, Maike Krenz, Ronald J Korthuis
Ischemic disorders, such as myocardial infarction, stroke, and peripheral vascular disease, are the most common causes of debilitating disease and death in westernized cultures. The extent of tissue injury relates directly to the extent of blood flow reduction and to the length of the ischemic period, which influence the levels to which cellular ATP and intracellular pH are reduced. By impairing ATPase-dependent ion transport, ischemia causes intracellular and mitochondrial calcium levels to increase (calcium overload)...
December 6, 2016: Comprehensive Physiology
https://www.readbyqxmd.com/read/28133528/effects-of-ellagic-acid-pretreatment-on-renal-functions-disturbances-induced-by-global-cerebral-ischemic-reperfusion-in-rat
#18
Khojasteh Hoseiny Nejad, Mohammad Kazem Gharib-Naseri, Alireza Sarkaki, Mahin Dianat, Mohammad Badavi, Yaghoub Farbood
OBJECTIVES: Global cerebral ischemia-reperfusion (GCIR) causes disturbances in brain functions as well as other organs such as kidney. Our aim was to evaluate the protective effects of ellagic acid (EA) on certain renal disfunction after GCIR. MATERIALS AND METHODS: Adult male Wistar rats (n=32, 250-300 g) were used. GCIR was induced by bilateral vertebral and common carotid arteries occlusion (4-VO). Animal groups were: 1) received DMSO/saline (10%) as solvent of EA, 2) solvent + GCIR, 3) EA + GCIR, and 4) EA...
January 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28132925/combined-nadph-and-the-nox-inhibitor-apocynin-provides-greater-anti-inflammatory-and-neuroprotective-effects-in-a-mouse-model-of-stroke
#19
Yuan-Yuan Qin, Mei Li, Xing Feng, Jian Wang, Lijuan Cao, Xi-Kui Shen, Jieyu Chen, Meiling Sun, Rui Sheng, Feng Han, Zheng-Hong Qin
Our previous study has reported that the pentose phosphate pathway product nicotinamide adenine dinucleotide phosphate (NADPH) protected neurons against ischemia/reperfusion-induced brain injury. NADPH can either act as a co-enzyme to produce GSH or a substrate of NADPH oxidase (NOX) to generate ROS. This study was designed to elucidate the effects of co-treatment with NADPH and NOX inhibitor apocynin on ischemia/reperfusion-induced brain inflammation and neuronal injury. The results showed that both NADPH and apocynin markedly attenuated ischemia/reperfusion-induced increases in the levels of NOX2, NOX4 and ROS...
January 26, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28132879/microrna-137-protects-neurons-against-ischemia-reperfusion-injury-through-regulation-of-the-notch-signaling-pathway
#20
Fangkun Shi, Zhiling Dong, Hualian Li, Xiaoman Liu, Hongmei Liu, Ruifang Dong
MicroRNAs (miRNAs) have emerged as novel regulators in various pathological processes including ischemic stroke. However, the precise role of miRNAs in ischemic stroke remains largely unknown. In this study, we investigated the role of miR-137 in the regulation of neuronal ischemia/reperfusion injury with oxygen-glucose deprivation and reoxygenation (OGD/R), a model of global brain ischemia. The results showed that miR-137 was significantly downregulated in neurons subjected to OGD/R treatment: OGD/R-induced cell injury was markedly inhibited by miR-137 overexpression and exacerbated by miR-137 suppression...
January 26, 2017: Experimental Cell Research
keyword
keyword
102259
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"