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https://www.readbyqxmd.com/read/28100078/percutaneous-microwave-ablation-mwa-increased-the-serum-levels-of-vegf-and-mmp-9-in-stage-i-non-small-cell-lung-cancer-nsclc
#1
Yang Ni, Xin Ye, Chao Wan, Qing Ni, Xia Yang, Guanghui Huang, Wenhong Li, Jiao Wang, Xiaoying Han, Zhigang Wei, Min Meng
BACKGROUND: Lung cancer is the leading cause of cancer death around the world. Percutaneous microwave ablation (MWA) is an emerging treatment strategy for medically inoperable early stage non-small cell lung cancer (NSCLC). In this study, we investigated the association of MWA and serum angiogensis promoters VEGF and MMP-9 in these patients subgroup. METHODS: We enrolled 52 patients with stage I NSCLC patients in this study. For each patient, blood samples were drawn by venous puncture, one immediately prior to MWA and the others on post-procedure days (PPD) 1, 3, 5, 7, 10 and 14...
January 18, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28066666/ct-guided-percutaneous-microwave-ablation-of-pulmonary-malignant-tumors
#2
Wei-Chun Ko, Yee-Fan Lee, Yi-Chang Chen, Ning Chien, Yu-Sen Huang, Yao-Hui Tseng, Jang-Ming Lee, Hsao-Hsun Hsu, Jin-Shing Chen, Yeun-Chung Chang
BACKGROUND: Microwave ablation (MWA) of lung tumors is a new approach for local tumor control. The purpose of this retrospective study was to evaluate the preliminary results of safety and efficacy of MWA with a dynamic frequency range (902-928 MHz) and power (10-32 W) for local tumor control of thoracic malignancies. METHODS: From December 1, 2013 to February 1, 2016, there were total 32 lung tumors among 15 patients (7 men, 8 women, age range 43-82 years, mean 57...
October 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28051018/apoptosis-of-lewis-lung-carcinoma-cells-induced-by-microwave-via-p53-and-proapoptotic-proteins-in-vivo
#3
Kou-Dong Zhang, Lin-Rong Tong, Shui-Ming Wang, Rui-Yun Peng, Hai-Dong Huang, Yu-Chao Dong, Xing-Xing Zhang, Qiang Li, Chong Bai
BACKGROUND: Microwave therapy is a minimal invasive procedure and has been employed in clinical practice for the treatment of various types of cancers. However, its therapeutic application in non-small-cell lung cancer and the underlying mechanism remains to be investigated. This study aimed to investigate its effect on Lewis lung carcinoma (LLC) tumor in vivo. METHODS: Fifty LLC tumor-bearing C57BL/6 mice were adopted to assess the effect of microwave radiation on the growth and apoptosis of LLC tumor in vivo...
2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28029227/physicochemical-antioxidant-and-cytotoxic-properties-of-xao-tam-phan-paramignya-trimera-root-extract-and-its-fractions
#4
Nguyen Van Tang, Jennette A Sakoff, Christopher J Scarlett
Xao tam phan (Paramignya trimera (Oliv.) Guillaum) has been used as a medicinal plant for cancer prevention and treatment in recent years. The objective of this study was to determine the physicochemical, antioxidant and cytotoxic properties of crude P. trimera root (PTR) extract and its fractions using methanol as a solvent and microwave-assisted extraction as an advanced technique for preparation of the PTR extract. The results showed that the PTR extract had high contents of saponins, phenolics, flavonoids and proanthocyanidins (7731...
December 28, 2016: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28011220/solvent-free-catalyst-free-microwave-or-grinding-assisted-synthesis-of-bis-cyclic-imide-derivatives-and-their-evaluation-for-anticancer-activity
#5
Anuj Kumar, Somesh Banerjee, Partha Roy, S M Sondhi, Anuj Sharma
Cyclic imides are well known to be very important antitumor agents such as mitonafide and amonafide etc. Based on this fact, we have synthesized two series of cyclic imide derivatives containing two cyclic imide moiety in their structures (bis-cyclic imides) and screened them for in vitro anticancer activity against five human cancer cell lines i.e. breast (T47D), lung (NCl H-522), colon (HCT-15), ovary (PA-1) and liver (Hep G2). One series of bis-cyclic imide derivatives (3a-h) have been synthesized by condensation of acid anhydrides (1a-b) with diamines (2a-d) and another series (9a-f, 10a-f, 11a-f and 12a-f) by condensation of various diamines (4a-f) with diacids (5-8) in good yields...
December 10, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27993505/microwave-ablation-for-lung-neoplasms-a-retrospective-analysis-of-long-term-results
#6
Terrance T Healey, Bradford T March, Grayson Baird, Damian E Dupuy
PURPOSE: To determine the long-term safety and efficacy of microwave (MW) ablation in the treatment of lung tumors at a single academic medical center. MATERIALS AND METHODS: Retrospective review was performed of 108 patients (42 female; mean age, 72.5 y ± 10.3 [standard deviation]) who underwent computed tomography (CT)-guided percutaneous MW ablation for a single lung malignancy. Eighty-two were primary non-small-cell lung cancers and 24 were metastatic tumors (9 colorectal carcinoma, 2 renal-cell carcinoma, 4 sarcoma, 2 lung, and 7 other)...
December 16, 2016: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/27900591/treatment-of-lung-tumours-with-high-energy-microwave-ablation-a-single-centre-experience
#7
Anna Maria Ierardi, Andrea Coppola, Natalie Lucchina, Gianpaolo Carrafiello
The purpose of our study is to report safety, technical success, effectiveness, local progression-free survival (LPFS) and overall survival of percutaneous microwave ablation (MWA) to treat lung tumours unsuitable for surgery. Nineteen patients with thirty-one tumours (mean diameter 2.4 cm) underwent percutaneous MWA in 28 sessions. Microwave ablation was carried out using a 2450-MHz generator (Emprint/Covidien, Boulder, CO, USA). Procedures were performed under cone-beam CT (CBCT) and under fluoro-CT (one session) guidance...
January 2017: Medical Oncology
https://www.readbyqxmd.com/read/27890402/multi-elemental-analysis-of-human-lung-samples-using-inductively-coupled-plasma-mass-spectrometry
#8
Jackie Morton, Emma Tan, S Kim Suvarna
The aim of this study was to establish concentrations of a wide range of elements in human lung samples to allow better identification of potential exposures in subsequent cases. This study reports concentrations of 48 elements (Al, As, Au, B, Ba, Be, Bi, Br, Cd, Ce, Co, Cr, Cs, Cu, Fe, Ga, Gd, Ge, Hf, Hg, In, Li, Mn, Mo, Nb, Ni, Os, Pb, Pd, Pt, Rb, Re, Ru, Sb, Se, Sm, Sn, Sr, Ta, Te, Ti, Tl, Tm, V, W, Y, Zn and Zr) in fresh lung tissue samples from 54 hospital patients, of which 93% exhibited various forms of neoplasia...
November 19, 2016: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/27881349/-diagnosis-of-drowning-by-detecting-gyrb-and-16s-rrna-genes-of-aeromonas-hydrophila-using-pcr-capillary-electrophoresis
#9
Bai-Sheng Mai, Qu-Yi Xu, Chao Liu, Jian Zhao, Ya-Li Han
OBJECTIVE: To establish a method for diagnosis of freshwater drowning by amplifying gyrB and 16S rRNA genes of Aeromonas hydrophila using PCR coupled with capillary electrophoresis (CE). METHODS: DNA samples were extracted from human, 18 planktons (including Candida albicans, Aeromonas hydrophila, and 16 species of algae), and 30 cases of tissue samples (including the lung, liver, and kidney, all examined with microwave digestion-vacuum filtration-automated scanning electron microscopy) from human cadavers, including 28 freshwater drowning victims and 2 with natural death...
November 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/27870682/advances-in-interventional-oncology-lung-cancer
#10
Philip J Dempsey, Carole A Ridge, Stephen B Solomon
Image-guided lung intervention in the oncologic patient includes transthoracic needle biopsy, thermal ablation, fiducial placement, and tunneled pleural catheter placement and is made possible by technical advancements in computed tomography, fluoroscopy, and ultrasound technology, as well as the proliferation of available thermal ablation modalities such as radiofrequency, microwave, and cryoablation. With increasingly earlier cancer diagnoses being made and a greater patient demand for minimally invasive therapies, interventional oncology has many options to offer the patient with thoracic malignancies...
November 2016: Cancer Journal
https://www.readbyqxmd.com/read/27833402/short-term-outcomes-and-safety-of-computed-tomography-guided-percutaneous-microwave-ablation-of-solitary-adrenal-metastasis-from-lung-cancer-a-multi-center-retrospective-study
#11
Min Men, Xin Ye, Weijun Fan, Kaixian Zhang, Jingwang Bi, Xia Yang, Aimin Zheng, Guanghui Huang, Zhigang Wei
OBJECTIVE: To retrospectively evaluate the short-term outcomes and safety of computed tomography (CT)-guided percutaneous microwave ablation (MWA) of solitary adrenal metastasis from lung cancer. MATERIALS AND METHODS: From May 2010 to April 2014, 31 patients with unilateral adrenal metastasis from lung cancer who were treated with CT-guided percutaneous MWA were enrolled. This study was conducted with approval from local Institutional Review Board. Clinical outcomes and complications of MWA were assessed...
November 2016: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/27810352/microwave-assisted-synthesis-structure-and-anti-tumor-activity-of-selenized-artemisia-sphaerocephala-polysaccharide
#12
Junlong Wang, Xiaoping Yang, Aijuan Bao, Xinlong Liu, Junyuan Zeng, Xiurong Liu, Jian Yao, Ji Zhang, Ziqiang Lei
In this work, selenylation of Artemisia sphaerocephala polysaccharide (SeASPMW) was studied by using H2SeO3/HNO3/BaCl2 reaction system in microwave field. SeASPMW exhibited the Se content range of 111-264μg/g with high yields (72.1-94.9%). (13)C NMR results indicated that the weak C-6 substitution was occurred. The decrease (from 7.348×10(4)g/mol to 1.736-4.667×10(4)g/mol) in weight average molecular mass (MW) of SeASPMW was observed in size exclusion chromatography combined with multi angle laser light scattering (SEC-MALLS) analysis...
February 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27789371/microwave-assisted-formulation-of-solid-lipid-nanoparticles-loaded-with-non-steroidal-anti-inflammatory-drugs
#13
Rohan M Shah, Daniel S Eldridge, Enzo A Palombo, Ian H Harding
Stearic acid-based solid lipid nanoparticles (SLNs) were prepared using the microwave assisted one-pot microemulsions procedure pioneered by our group. In this study, non-steroidal anti-inflammatory drugs (NSAIDs) including indomethacin, ketoprofen and nimesulide were selected as ideal "test" drugs, based on their poor water solubility. The model drugs were incorporated within the SLNs by the microwave-assisted procedure at the time of SLN production. The microwave-produced drug-loaded SLNs were evaluated in terms of their physicochemical characteristics, drug release behavior and their uptake into against A549 cell line (human lung epithelial cells)...
December 30, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27789077/local-efficacy-and-survival-after-microwave-ablation-of-lung-tumors-a-retrospective-study-in-183-patients
#14
Aimin Zheng, Xin Ye, Xia Yang, Guanghui Huang, Yonghao Gai
PURPOSE: To retrospectively evaluate local efficacy and survival after microwave (MW) ablation of lung tumors and identify predictors of prognosis. MATERIALS AND METHODS: Data from 183 consecutive patients (67 women; mean age, 61.5 y ± 13.4) with lung tumors who had undergone 203 lung MW ablation sessions from January 2011 to May 2013 were assessed. The χ(2) test, independent-samples t test, Kaplan-Meier analysis, and Cox regression model analysis were used to estimate survival rates and evaluate significance of factors affecting rates of incomplete ablation, local progression, remote progression-free survival (RPFS), and cancer-specific survival (CSS)...
December 2016: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/27776982/percutaneous-thermal-ablation-for-small-cell-lung-cancer-initial-experience-with-ten-tumors-in-nine-patients
#15
Aaron W P Maxwell, Terrance T Healey, Damian E Dupuy
PURPOSE: To evaluate outcomes in a small cohort of patients with local or disseminated small-cell lung cancer (SCLC) who received percutaneous thermal ablation therapy. MATERIALS AND METHODS: Ten biopsy-proven SCLC tumors in 9 consecutive patients (5 men, 4 women; average age, 73.8 y ± 12.4) were retrospectively evaluated. Average tumor sizes were 1.8 cm ± 0.5 and 2.6 cm ± 1.2 among patients with local and disseminated disease, respectively. Microwave and radiofrequency ablation were each used for 5 tumors...
December 2016: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/27732159/pulmonary-microwave-ablation-near-the-heart-antenna-positioning-can-mitigate-cardiac-complications-in-a-porcine-model
#16
George A Carberry, Elisabetta Nocerino, Peter J Mason, Denise J Schwahn, Scott Hetzel, Alyssa M Turnquist, Fred T Lee, Christopher L Brace
Purpose To determine how close to the heart pulmonary microwave ablation can be performed without causing cardiac tissue injury or significant arrhythmia. Materials and Methods The study was performed with approval from the institutional animal care and use committee. Computed tomographic fluoroscopically guided microwave ablation of the lung was performed in 12 swine. Antennas were randomized to either parallel (180° ± 20°) or perpendicular (90° ± 20°) orientation relative to the heart surface and to distances of 0-10 mm from the heart...
October 12, 2016: Radiology
https://www.readbyqxmd.com/read/27721758/navigated-percutaneous-lung-ablation-under-high-frequency-jet-ventilation-of-a-metastasis-from-a-wilms-tumour-a-paediatric-case-report
#17
Jacob Freedman, Piotr Harbut
This is a case report of microwave energy being used to ablate an inoperable metastasis of a Wilms' tumour in a 6-year-old boy using state-of-the-art navigated computed tomography targeting and high-frequency jet ventilation to reduce organ displacement and the potential risk of procedure-related pneumothorax. After the ablation, the young boy had high-dose chemotherapy followed by an autologous stem cell transplantation with rapid reduction of three recurrent right-sided lung metastases.
May 2016: Case Reports in Oncology
https://www.readbyqxmd.com/read/27692673/percutaneous-thermal-ablation-of-primary-lung-cancer
#18
T de Baere, L Tselikas, V Catena, X Buy, F Deschamps, J Palussière
Percutaneous ablation of small-size non-small-cell lung cancer (NSCLC) has demonstrated feasibility and safety in nonsurgical candidates. Radiofrequency ablation (RFA), the most commonly used technique, has an 80-90% reported rate of complete ablation, with the best results obtained in tumors less than 2-3cm in diameter. The highest one-, three-, and five-year overall survival rates reported in NSCLC following RFA are 97.7%, 72.9%, and 55.7% respectively. Tumor size, tumor stage, and underlying comorbidities are the main predictors of survival...
October 2016: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/27680945/thermal-ablation-of-colorectal-lung-metastases-retrospective-comparison-among-laser-induced-thermotherapy-radiofrequency-ablation-and-microwave-ablation
#19
Thomas J Vogl, Romina Eckert, Nagy N N Naguib, Martin Beeres, Tatjana Gruber-Rouh, Nour-Eldin A Nour-Eldin
OBJECTIVE: The purpose of this study is to retrospectively evaluate local tumor control, time to tumor progression, and survival rates among patients with lung metastatic colorectal cancer who have undergone ablation therapy performed using laser-induced thermotherapy (LITT), radiofrequency ablation (RFA), or microwave ablation (MWA). MATERIALS AND METHODS: Data for this retrospective study were collected from 231 CT-guided ablation sessions performed for 109 patients (71 men and 38 women; mean [± SD] age, 68...
December 2016: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/27676207/immunohistochemical-localization-of-androgen-receptors-in-female-mole-rat-spalax-leucodon-tissues
#20
F M Gur, S Timurkaan
Androgens exert their effects through androgen receptors (AR) in tissues. We investigated the distribution of AR in female mole rat tissues. Tissues were excised, fixed with 10% formalin and embedded in paraffin. Sections were stained after microwave antigen retrieval for immunohistochemistry. Immunostaining of AR immunostaining was detected in the nucleus or cytoplasm of the cells in the cerebral cortex, cerebellum, anterior pituitary, lung, liver, uterus and skin. Granulosa and some thecal cells in the ovary, cardiac muscle cells and adipose cells exhibited a nuclear reaction for AR...
October 2016: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
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