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https://www.readbyqxmd.com/read/29143160/solvent-free-synthesis-and-anticancer-activity-evaluation-of-benzimidazole-and-perimidine-derivatives
#1
Anuj Kumar, Somesh Banerjee, Partha Roy, S M Sondhi, Anuj Sharma
Benzimidazoles and perimidines are subsidiary structures for research and development of new biologically active molecules and have established prominence because of their promising biological activities. Two series of diversified heterocyclic molecules, tetracyclic benzimidazole derivatives, tetracyclic and pentacyclic perimidine derivatives have been synthesized in good yields by condensation of acid anhydrides and diacids with various diamines using microwave irradiation. All synthesized derivatives were fully characterized and evaluated for in vitro antiproliferative activity against five human cancer cell lines...
November 15, 2017: Molecular Diversity
https://www.readbyqxmd.com/read/29133046/design-synthesis-and-biological-evaluation-of-novel-benzimidazole-amidines-as-potent-multi-target-inhibitors-for-the-treatment-of-non-small-cell-lung-cancer
#2
Andrea Bistrović, Luka Krstulović, Anja Harej, Petra Grbčić, Mirela Sedić, Sanja Koštrun, Sandra Kraljević Pavelić, Miroslav Bajić, Silvana Raić-Malić
A series of novel amidino 2-substituted benzimidazoles linked to 1,4-disubstituted 1,2,3-triazoles were synthesized by implementation of microwave and ultrasound irradiation in click reaction and subsequent condensation of thus obtained 4-(1,2,3-triazol-1-yl)benzaldehyde with o-phenylenediamines. In vitro antiproliferative screening of compounds performed on human cancer cell lines revealed that p-chlorophenyl-substituted 1,2,3-triazolyl N-isopropylamidine 10c and benzyl-substituted 1,2,3-triazolyl imidazoline 11f benzimidazoles had selective and potent cytostatic activities in the low nM range against non-small cell lung cancer cell line A549, which could be attributed to induction of apoptosis and primary necrosis...
November 10, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29129514/a-green-multicomponent-synthesis-of-tocopherol-analogues-with-antiproliferative-activities
#3
Mariana Ingold, Rosina Dapueto, Sabina Victoria, Germán Galliusi, Carlos Batthyàny, Mariela Bollati-Fogolín, David Tejedor, Fernando García-Tellado, José M Padrón, Williams Porcal, Gloria V López
A one-pot efficient, practical and eco-friendly synthesis of tocopherol analogues has been developed using water or solvent free conditions via Passerini and Ugi multicomponent reactions. These reactions can be optimized using microwave irradiation or ultrasound as the energy source. Accordingly, a small library of 30 compounds was prepared for biological tests. The evaluation of the antiproliferative activity in the human solid tumor cell lines A549 (lung), HBL-100 (breast), HeLa (cervix), SW1573 (lung), T-47D (breast), and WiDr (colon) provided lead compounds with GI50 values between 1 and 5 μM...
November 3, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29108305/ct-guided-microwave-ablation-through-the-lungs-for-treating-liver-tumors-near-the-diaphragm
#4
Han Qi, Hao Zhang, Chao Wan, Lin Xie, Ze Song, Weijun Fan
Purpose: To explore the short-term efficacy and safety of CT-guided microwave ablation (MWA) for treating liver tumors near the diaphragm. Results: The complete response (CR) rate for CT-guided MWA through the lung was 94.7% (124/131). The incomplete response (ICR) rate was 5.3% (7/131), of which 6 patients with ICRs achieved CRs after MWA. The CR rate for Group I was higher than Group II (99.0% vs. 80.0%, P=0.001). The mean follow-up time was 11.2 ±7.50 months...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29096018/massive-fatal-pulmonary-haemorrhage-during-bevacizumab-treatment-following-microwave-ablation-therapy-for-oligometastatic-lung-metastasis-from-rectal-cancer
#5
Thiru Prasanna, Greg Briggs, Sanjiv Jain, Desmond Yip
Although thoracic ablative therapies are generally safe procedures, fatal complications can occur. Bevacizumab is a standard-of-care treatment along with chemotherapy for metastatic colorectal cancer. Although uncommon, unpredictable serious adverse events can occur secondary to bevacizumab. We report a case of fatal intrapulmonary haemorrhage as a result of arteriopulmonary fistula in a patient after microwave ablation of pulmonary colorectal cancer metastasis while on bevacizumab. Antiangiogenetic properties of bevacizumab are associated with delayed wound healing, which might have been a crucial factor in the development of arteriopulmonary fistula and haemorrhage...
October 31, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28957090/photonic-microwave-time-delay-using-slow-and-fast-light-effects-in-optically-injected-semiconductor-lasers
#6
Kun-Lin Hsieh, Sheng-Kwang Hwang, Chin-Lung Yang
This study numerically and experimentally investigates a photonic approach for microwave time delay, which takes advantage of the redshift of the laser cavity resonance induced by external optical injection in a semiconductor laser. The strong enhancement around the redshifted cavity resonance not only amplifies the power, but also shifts the phase of the microwave signals carried by the optical injection. Such a microwave phase shift is approximately linear over a few gigahertz, leading to a constant microwave time delay over the frequency range...
September 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28940654/video-assisted-microwave-ablation-for-the-treatment-of-a-metastatic-lung-lesion-in-a-dog-with-appendicular-osteosarcoma-and-hypertrophic-osteopathy
#7
Kaitlyn Mazzaccari, Sarah E Boston, Beau B Toskich, Kristina Bowles, J Brad Case
OBJECTIVE: To describe video-assisted microwave ablation (VAMA) for the treatment of a metastatic lung lesion secondary to right forelimb osteosarcoma in a dog. STUDY DESIGN: Case report. ANIMALS: A 10-year-old female spayed mixed breed dog with a metastatic lung lesion secondary to appendicular osteosarcoma. METHODS: An osteosarcoma of the right distal scapula and proximal humerus that was suspected to be a radiation-induced osteosarcoma was treated with limb amputation and carboplatin chemotherapy...
September 22, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/28927661/local-control-and-survival-after-image-guided-percutaneous-ablation-of%C3%A2-adrenal%C3%A2-metastases
#8
Nathan E Frenk, Dania Daye, Kemal Tuncali, Ronald S Arellano, Paul B Shyn, Stuart G Silverman, Florian J Fintelmann, Raul N Uppot
PURPOSE: To evaluate local control and survival after image-guided ablation of adrenal gland metastases. MATERIALS AND METHODS: Image-guided ablations of adrenal metastases measuring < 5 cm performed at 2 academic medical centers between July 2002 and June 2016 were analyzed. There were 51 procedures performed on 46 tumors (mean diameter 2.8 cm ± 1.1; range, 0.7-4.9 cm) in 38 patients (mean age 66 y; range, 41-80 y) with renal cell carcinoma (n = 17 patients; 45%), non-small cell lung cancer (n = 10 patients; 26%), and other primary malignancies (n = 11 patients; 29%)...
September 16, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28915624/microwave-ablation-combined-with-egfr-tkis-versus-only-egfr-tkis-in-advanced-nsclc-patients-with-egfr-sensitive-mutations
#9
Zhigang Wei, Xin Ye, Xia Yang, Aimin Zheng, Guanghui Huang, Wenhong Li, Jiao Wang, Xiaoying Han, Min Meng, Yang Ni
We conducted this retrospective study to investigate whether microwave ablation (MWA) of primary tumor sites plus epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) could improve survival in advanced non small cell lung cancer (NSCLC) with EGFR mutations. MWA was conducted at the primary tumor sites, followed by EGFR-TKIs in the MWA plus EGFR-TKIs group. EGFR-TKIs were administered until disease progression or intolerable toxicity. The primary endpoint was progression-free survival (PFS); secondary endpoints were overall survival (OS) and objective response rate (ORR)...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28913628/delayed-bronchocutaneous-fistula-without-pneumothorax-following-a-microwave-ablation-of-a-recurrent-pulmonary-metastasis
#10
Arnaud Thivolet, Badis Menassel, Gérard Chatté, Mayeul Tabutin, Amine Bouhamama, Frank Pilleul, Charles Mastier
Percutaneous tumor ablations are rather safe and effective treatments in selected patients for non-operable non-small cell lung carcinomas or lung metastases. However, there are major complications such as bronchopleural or bronchocutaneous fistula, which it is important to know in order to manage them safely. We describe in this report a case of bronchocutaneous fistula without pneumothorax following a microwave ablation of a recurrent pulmonary metastasis and its management.
September 14, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28901314/repeated-percutaneous-microwave-ablation-for-local-recurrence-of-inoperable-stage-i-nonsmall-cell-lung-cancer
#11
Xia Yang, Xin Ye, Guanghui Huang, Xiaoying Han, Jiao Wang, Wenhong Li, Zhigang Wei, Min Meng
BACKGROUND: The safety and effectiveness of repeated computed tomography-guided percutaneous microwave ablation (MWA) in the management of local recurrence (LR) in patients with medically inoperable Stage I nonsmall cell lung cancer (NSCLC) were retrospectively evaluated. MATERIALS AND METHODS: From February 2008 to August 2014, 104 patients with medically inoperable Stage I NSCLC received MWA. Patients with LR were given repeat MWA. The clinical outcomes and complications of repeat MWA for LR were evaluated...
2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28877612/the-role-of-mri-in-the-early-evaluation-of-lung-microwave-ablation
#12
Andrei Roman, Benjamin Kaltenbach, Tatjana Gruber-Rouh, Nagy N Naguib, Thomas J Vogl, Nour-Eldin A Nour-Eldin
PURPOSE: To retrospectively investigate the role of a contrast enhanced MRI (ceMRI) performed 24 hours after a microwave ablation (MWA) of the lung, in predicting local tumor progression (LTP) and detecting complications compared to an unenhanced CT Material and methods: Forty-nine patients that underwent MWA of 77 lung metastases between 2008 and 2015 were included. All patients received an unenhanced chest CT and a ceMRI (including T2 and ceT1) 24h after MWA. The conspicuities of the peripheral rim and of the ablated tumor were scored using 1-3 scales and compared between examinations...
September 6, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28869200/irreversible-electroporation-and-thermal-ablation-of-tumors-in-the-liver-lung-kidney-and-bone-what-are-the-differences
#13
REVIEW
L G P H Vroomen, E N Petre, F H Cornelis, S B Solomon, G Srimathveeravalli
Focal treatment with radiofrequency, microwave and cryoablation has been increasingly used for the treatment of tumors in patients who cannot undergo surgical resection and in select patients with early stage or oligometastatic disease. Each of these ablation modalities has a unique working principle and biophysics underlying the ablative effect, which largely determines the clinical indication for its application. Irreversible electroporation, a relatively new ablation technique with a predominantly nonthermal cell killing mechanism has emerged as an alternative treatment technique for tumors that are contraindicated for thermal ablation because of safety or efficacy considerations...
September 2017: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/28844613/percutaneous-thermal-ablation-of-lung-tumors-radiofrequency-microwave-and-cryotherapy-where-are-we-going
#14
J Palussière, V Catena, X Buy
Main indications of percutaneous pulmonary thermal ablation are early stage non-small cell lung carcinoma (NSCLC) for patients who are not amenable to surgery and slow-evolving localized metastatic disease, either spontaneous or following a general treatment. Radiofrequency ablation (RFA) is the most evaluated technique. This technique offers a local control rate ranging between 80 and 90% for tumors <3cm in diameter. Other more recently used ablation techniques such as microwaves and cryotherapy could overcome some limitations of RFA...
September 2017: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/28816439/1-3-dipolar-cycloaddition-reactions-for-the-synthesis-of-novel-oxindole-derivatives-and-their-cytotoxic-properties
#15
Prakash R Mali, Prashishkumar K Shirsat, Navnath Khomane, Lakshama Nayak, Jagadeesh Babu Nanubolu, H M Meshram
The multicomponent reaction between isatin, amino acid, but-2-ynedioates, and phenacyl bromide has been developed using microwave irradiation under catalyst and base-free conditions in aqueous medium. This synthetic protocol is useful for the synthesis of various functionalized spirooxindole derivatives. This MCR exhibits a broad substrate scope with excellent yields and shorter reaction time. Additionally the synthesized spirooxindole derivatives were evaluated for their anticancer activity against three human cancer cell lines: MCF-7 (breast), A549 (lung), and HeLa cervical...
October 9, 2017: ACS Combinatorial Science
https://www.readbyqxmd.com/read/28754760/accidental-hypothermic-cardiac-arrest-and-rapid-mediastinal-warming-with-pleural-lavage-a-survivor-after-3-5-hours-of-manual-cpr
#16
George Little
A 30-year-old man suffered post-traumatic hypothermic cardiac arrest. On arrival in the emergency department, rectal core temperature was 23°C. Manual cardiopulmonary resuscitation (CPR) was continued as no mechanical chest compression device was available, and active and passive rewarming was undertaken. Bilateral thoracostomies confirmed good lung inflation. Defibrillation and intravenous epinephrine were discontinued until core temperature was elevated above 30°C. Extracorporeal rewarming was unavailable...
July 27, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28707652/thermal-ablation-in-the-management-of-adrenal-metastasis-originating-from-non-small-cell-lung-cancer-a-5-year-single-center-experience
#17
Evanthia I Botsa, Ioanna L Thanou, Aspasia T Papatheodoropoulou, Loukas I Thanos
BACKGROUND: Treatment of adrenal metastasis from lung carcinoma may prolong survival in the selected patients. However, not all patients can undergo surgery; thus, minimally invasive ablation procedures such as radiofrequency ablation (RFA) and microwave ablation (MWA) have gained acceptance as alternative treatment methods. This study summarized a 5-year single-center experience regarding the evaluation of safety and efficacy of computed tomography (CT)-guided thermal ablation in the management of adrenal metastasis originating from non-small cell lung cancer (NSCLC)...
September 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28668476/conventional-and-microwave-assisted-synthesis-of-new-1h-benzimidazole-thiazolidinedione-derivatives-a-potential-anticancer-scaffold
#18
Pankaj Sharma, T Srinivasa Reddy, Niggula Praveen Kumar, Kishna Ram Senwar, Suresh K Bhargava, Nagula Shankaraiah
A series of new benzimidazole bearing thiazolidinedione derivatives has been designed, synthesized by using conventional as well as microwave-assisted methods. Microwave-assisted synthesis caused a significant reduction in the reaction times and improvement in the yields of all the derivatives. All the new synthesized compounds were evaluated for their in vitro cytotoxic potential against selected human cancer cell lines of breast (MDAMB-231), prostate (PC-3), cervical (HeLa), lung (A549) and bone (HT1080) along with a normal kidney cells (HeK-293T)...
September 29, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28634173/a-comparison-of-2-respiratory-devices-for-sputum-clearance-in-adults-with-non-cystic-fibrosis-bronchiectasis
#19
Yasmin R Silva, Tracy A Greer, Lucy C Morgan, Frank Li, Claude S Farah
BACKGROUND: Airway clearance techniques are a vital part of routine care for patients with bronchiectasis. There is no clear superior modality. The Flutter combines oscillations (6-20 Hz) and positive expiratory pressure; the Lung Flute combines positive expiratory pressure and low frequency acoustic waves (18-22 Hz), to augment clearance. This project aimed to compare these devices. METHODS: This was a randomized crossover study of adult subjects with stable non-cystic fibrosis bronchiectasis (expectorating > 25 mL/d)...
October 2017: Respiratory Care
https://www.readbyqxmd.com/read/28599296/microwave-ablation-combined-with-egfr-tkis-versus-only-egfr-tkis-in-advanced-nsclc-patients-with-egfr-sensitive-mutations
#20
Zhigang Wei, Xin Ye, Xia Yang, Aimin Zheng, Guanghui Huang, Wenhong Li, Jiao Wang, Xiaoying Han, Min Meng, Yang Ni
We conducted this retrospective study to investigate whether microwave ablation (MWA) of primary tumor sites plus epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) could improve survival in advanced non small cell lung cancer (NSCLC) with EGFR mutations. MWA was conducted at the primary tumor sites, followed by EGFR-TKIs in the MWA plus EGFR-TKIs group. EGFR-TKIs were administered until disease progression or intolerable toxicity. The primary endpoint was progression-free survival (PFS); secondary endpoints were overall survival (OS) and objective response rate (ORR)...
May 23, 2017: Oncotarget
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