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https://www.readbyqxmd.com/read/29773189/effects-of-furosemide-administration-on-the-concentration-of-essential-and-toxic-elements-in-wistar-rats-by-inductively-coupled-plasma-optical-emission-spectrometry
#1
Luiz Raimundo Seneterri Silva Rodrigues Dos Santos, Aníbal de Freitas Santos, Maria das Graças Andrade Korn
Furosemide can interfere with the metabolism of chemical elements, changing their levels in several tissues, thus causing imbalance. In this study, inductively coupled plasma optical emission spectrometry (ICP OES) was used for multi-element analysis (Cd, Cu, Fe, Mg, Pb, Se and Zn) after microwave-assisted digestion, to evaluate the effect of furosemide (loop diuretic) on the composition of these essential and toxic elements in biological samples (liver, kidney, heart, lung and serum) of Wistar rats. Male and female Wistar rats (n = 40, 180-350 g) were randomly divided into 2 groups (n = 20/group)...
July 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29765626/a-focused-library-synthesis-and-cytotoxicity-of-quinones-derived-from-the-natural-product-bolinaquinone
#2
Azadeh Ghods, Jayne Gilbert, Jennifer R Baker, Cecilia C Russell, Jennette A Sakoff, Adam McCluskey
Bolinaquinone is a natural product that is a structurally complex, cytotoxic sesquiterpene quinone. A scaffold simplification and focused library approach using a microwave-assisted Suzuki coupling gave 32 bolinaquinone analogues with good-to-excellent cytotoxicity profiles. Mono-arylbenzoquinones, Library A , were preferentially toxic towards BE2-C (neuroblastoma) cells with growth inhibition (GI50 ) values of 4-12 µM; only the 3,4-dimethoxyphenyl 23 and 3-biphenyl 28 variants were broad-spectrum active-HT29 (colon carcinoma), U87 and SJ-G2 (glioblastoma), MCF-7 (breast carcinoma), A2780 (ovarian carcinoma), H460 (lung carcinoma), A431 (skin carcinoma), Du145 (prostate carcinoma), BE2-C (neuroblastoma), MIA (pancreatic carcinoma) and SMA (spontaneous murine astrocytoma)...
April 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29734739/synthesis-of-new-glycosylated-flavonoids-with-inhibitory-activity-on-cell-growth
#3
Ana R Neves, Marta Correia-da-Silva, Patrícia M A Silva, Diana Ribeiro, Emília Sousa, Hassan Bousbaa, Madalena Pinto
Natural flavonoids and xanthone glycosides display several biological activities, with the glycoside moiety playing an important role in the mechanism of action of these metabolites. Herein, to give further insights into the inhibitory activity on cell growth of these classes of compounds, the synthesis of four flavonoids ( 5 , 6 , 9 , and 10 ) and one xanthone ( 7 ) containing one or more acetoglycoside moieties was carried out. Acetyl groups were introduced using acetic anhydride and microwave irradiation...
May 5, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29679218/targeting-matrix-metalloproteinases-with-novel-diazepine-substituted-cinnamic-acid-derivatives-design-synthesis-in-vitro-and-in-silico-studies
#4
Dharmender Rathee, Viney Lather, Ajmer Singh Grewal, Harish Dureja
Lung cancer is the notable cause of cancer associated deaths worldwide. Recent studies revealed that the expression of matrix metalloproteinases (MMPs) is extremely high in lung tumors compared with non-malignant lung tissue. MMPs (-2 and -9) play an important part in tumor development and angiogenesis, which suggests that creating potent MMP-2 and -9 inhibitors, should be an important goal in lung cancer therapy. In the present study, an effort has been made to develop new anti-metastatic and anti-invasive agents, wherein a series of novel diazepine substituted cinnamic acid derivatives were designed, synthesized and assayed for their inhibitory activities on MMP-2 and MMP-9...
April 20, 2018: Chemistry Central Journal
https://www.readbyqxmd.com/read/29667120/chromium-in-postmortem-material
#5
Danuta Dudek-Adamska, Teresa Lech, Tomasz Konopka, Paweł Kościelniak
Recently, considerable attention has been paid to the negative effects caused by the presence and constant increase in concentration of heavy metals in the environment, as well as to the determination of their content in human biological samples. In this paper, the concentration of chromium in samples of blood and internal organs collected at autopsy from 21 female and 39 male non-occupationally exposed subjects is presented. Elemental analysis was carried out by an electrothermal atomic absorption spectrometer after microwave-assisted acid digestion...
April 17, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29564534/green-synthesis-of-stereospermum-suaveolens-capped-silver-and-gold-nanoparticles-and-assessment-of-their-innate-antioxidant-antimicrobial-and-antiproliferative-activities
#6
Sijo Francis, Ebey P Koshy, Beena Mathew
Plant-extract mediated nanoparticles synthesis is a viable alternative to chemical reduction techniques. Here, we report the microwave-assisted rapid synthesis of silver and gold nanoparticles by the phytoreducer Stereospermum suaveolens for the first time. The formation of the nascent silver and gold nanoparticles is confirmed by their intense surface plasmon resonance peaks at 431 and 585 nm in UV-visible spectroscopy. The poly phenolic and alcoholic functional groups present in the aqueous root bark extract that performed the bioreduction processes have been detected using Fourier transform infrared spectroscopy...
March 21, 2018: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/29531858/preparation-and-evaluation-of-a-68-ga-labeled-rgd-containing-octapeptide-for-noninvasive-imaging-of-angiogenesis-biodistribution-in-non-human-primate
#7
Irina Velikyan, Örjan Lindhe
Monitoring general disease marker such as angiogenesis may contribute to the development of personalized medicine and improve therapy outcome. Readily availability of positron emitter based imaging agents providing quantification would expand clinical positron emission tomography (PET) applications. Generator produced68 Ga provides PET images of high resolution and the half-life time frame is compatible with the pharmacokinetics of small peptides comprising arginine-glycine-aspartic acid (RGD) sequence specific to αv β3 integrin receptors...
2018: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29530051/serum-proton-nmr-metabolomics-analysis-of-human-lung-cancer-following-microwave-ablation
#8
Jian-Ming Hu, Huang-Tao Sun
BACKGROUND: To find potential serum biomarkers of microwave ablation (MWA) for treatment of human lung cancer by1 H nuclear magnetic resonance (NMR)-based metabolomics analysis. METHODS: Serum specimens collected from 43 healthy individuals, 39 patients with advanced non-small cell lung cancer (NSCLC) and 38 NSCLC patients treated with MWA, were subjected to1 H NMR-based metabolomics analysis. Partial least squares discriminant analysis was used to analyze the data...
March 12, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29527825/microwave-ablation-for-lung-cancer-patients-with-a-single-lung-clinical-evaluation-of-11-cases
#9
Xia Yang, Xin Ye, Licheng Zhang, Dianzhong Geng, Zhenli Du, Guohua Yu, Haipeng Ren, Jiao Wang, Guanghui Huang, Zhigang Wei, Yang Ni, Wenhong Li, Xiaoying Han
BACKGROUND: The study was conducted to retrospectively evaluate the safety and effectiveness of computed tomography (CT)-guided percutaneous microwave ablation (MWA) for peripheral non-small cell lung cancer (NSCLC) in 11 patients with a single lung after pneumonectomy. METHODS: From May 2011 to March 2015, 11 single-lung patients (8 men and 3 women; mean age 60.3 years, range 46-71) with peripheral NSCLC underwent 12 sessions of MWA. Eleven tumors measuring 13-52 mm (mean 30...
March 12, 2018: Thoracic Cancer
https://www.readbyqxmd.com/read/29513313/bioimaging-of-isosteric-osmium-and-ruthenium-anticancer-agents-by-la-icp-ms
#10
Matthias H M Klose, Sarah Theiner, Christoph Kornauth, Samuel M Meier-Menches, Petra Heffeter, Walter Berger, Gunda Koellensperger, Bernhard K Keppler
Laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) was used to study the spatial distribution of two metallodrugs with anticancer activities in vivo, namely the organoruthenium plecstatin-1 (1) and its isosteric osmium analogue (2), in liver, kidneys, muscles and tumours of treated mice bearing a CT-26 tumour after single-dose i.p. administration. To the best of our knowledge, this is the first time that the spatial distribution of an osmium drug candidate has been investigated using LA-ICP-MS in tissues...
March 1, 2018: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/29490524/high-power-microwave-ablation-of-normal-swine-lung-impact-of-duration-of-energy-delivery-on-adverse-event-and-heat-sink-effects
#11
Hiroshi Kodama, Eisuke Ueshima, Song Gao, Sebastien Monette, Lee-Ronn Paluch, Kreg Howk, Joseph P Erinjeri, Stephen B Solomon, Govindarajan Srimathveeravalli
PURPOSE: The purpose of this study is to assess the impact of duration of energy delivery on adverse events (AEs) and heat sink effects during high power microwave ablation (MWA) of normal swine lung. MATERIALS AND METHODS: High power (100 W) MWA was performed with short (2 min, 18 ablations) or long (10 min, nine ablations) duration of energy delivery in unilateral lung of swine (n = 10). CT imaging was done prior to sacrifice at 2 or 28 d post-treatment, with additional imaging at 7 and 14 d for the latter cohort...
April 18, 2018: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29483431/-prolonged-survival-achieved-with-surgical-resection-and-multidisciplinary-therapy-for-acinar-cell-carcinoma-of-the-pancreas-with-liver-metastases
#12
Kyohei Kanematsu, Yuki Suematsu, Shunsuke Yamagishi, Miyuki Takahashi, Hiroyuki Saito, Mao Nakayama, Michiko Fukabori, Kazuhiko Wakabayashi, Yutaka Ito
We report 2 cases of prolonged survival achieved with surgical resection and multidisciplinary therapy for acinar cell carcinoma of the pancreas with liver metastases.Case 1: The patient was a 55-year-old woman.She presented with upper right abdominal pain and anemia.We diagnosed a tumor originating from the pancreas and multiple liver metastases.To avoid death caused by bleeding from the tumor, we performed pancreaticoduodenectomy and right-hemi hepatectomy, and a rapid diagnosis of acinar cell carcinoma of the pancreas was confirmed intraoperatively...
February 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29464274/percutaneous-microwave-ablation-for-local-control-of-metastatic-renal-cell-carcinoma
#13
Kimberly A Maciolek, E Jason Abel, Sara L Best, Hamid Emamekhoo, Sarah L Averill, Timothy J Ziemlewicz, Meghan G Lubner, J Louis Hinshaw, Fred T Lee, Shane A Wells
PURPOSE: The purpose of the article is to evaluate the safety and oncologic efficacy of microwave ablation for metastatic renal cell carcinoma (mRCC). MATERIALS AND METHODS: From September 2011 to December 2016, 33 mRCC were ablated in 18 patients using percutaneous microwave ablation. Sites of mRCC include retroperitoneum (n = 12), contralateral kidney (n = 6), liver (n = 6), lung (n = 5), adrenal gland (n = 5). Technical success, local, and distant tumor progression, and complications were assessed at immediate and follow-up imaging...
February 20, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29378462/comparison-between-microwave-ablation-and-lobectomy-for-stage-i-non-small-cell-lung-cancer-a-propensity-score-analysis
#14
Wang Yao, Mingjian Lu, Wenzhe Fan, Jinhua Huang, Yangkui Gu, Fei Gao, Yu Wang, Jiaping Li, Zhihua Zhu
PURPOSE: To compare the effectiveness and complication between microwave ablation and lobectomy for stage I non-small cell lung cancer. MATERIALS AND METHODS: This retrospective study was approved by two institutional ethics committees and all patients were provided with informed consent. From January 2000 to December 2010, 54 and 795 stage I patients who underwent microwave ablation and lobectomy were included in this study. A matched cohort composed of 54 and 108 patients in the microwave ablation and the lobectomy group were selected after adjustment with 1:2 propensity score matching...
February 12, 2018: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29352930/an-efficient-approach-to-prepare-sulfated-polysaccharide-and-evaluation-of-anti-tumor-activities-in-vitro
#15
Junlong Wang, Aijuan Bao, Xinhua Meng, Hongyun Guo, Yongdong Zhang, Yali Zhao, Weibao Kong, Junyu Liang, Jian Yao, Ji Zhang
Use of microwave radiation is one of the most potential techniques in polysaccharide derivatives synthesis due to its advantages such as higher yields, milder reaction conditions and shorter reaction times. This study was aimed at producing sulfated polysaccharides by microwave irradiation using polar reagents and solvent. Six sulfated Artemisia sphaerocephala polysaccharide derivatives (SPAS) were obtained by using chlorosulfuric acid/pyridine method in the reaction duration range of 15-300 min at a fixed microwave power of 100W...
March 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29329887/determination-of-n-glycans-by-high-performance-liquid-chromatography-using-6-aminoquinolyl-n-hydroxysuccinimidyl-carbamate-as-the-glycosylamine-labeling-reagent
#16
Yike Wu, Qiuyue Sha, Juan Du, Chang Wang, Liang Zhang, Bi-Feng Liu, Yawei Lin, Xin Liu
Robust, efficient identification and accurate quantification of N-glycans are of great significance in N-glycomics analysis. Here, a simple and rapid derivatization method, based on the combination of microwave-assisted deglycosylation and 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate (AQC) labeling, was developed for the analysis of N-glycan by high performance liquid chromatography with fluorescence detection (HPLC-FLD). After optimizing various parameters affecting deglycosylation and derivatization by RNase B, the time for N-glycan labeling was shortened to 50 min with ∼10-fold enhancement in detection sensitivity comparing to conventional 2-aminobenzoic acid (2-AA) labeling method...
February 2, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29317376/a-comparison-between-915-mhz-and-2450-mhz-microwave-ablation-systems-for-the-treatment-of-small-diameter-lung-metastases
#17
Thomas J Vogl, Andrei Roman, Nour-Eldin A Nour-Eldin, Wolfgang Hohenforst-Schmidt, Iliana Bednarova, Benjamin Kaltenbach
PURPOSE: We aimed to retrospectively compare the local tumor control rates between low frequency (LF) and high frequency (HF) microwave ablation devices in the treatment of <3 cm lung metastases. METHODS: A total of 36 patients (55 tumors) were treated with the LF system (915 MHz) and 30 patients (39 tumors) were treated with the HF system (2450 MHz) between January 2011 and March 2016. Computed tomography (CT) scans performed prior to and 24 hours after the ablation were used to measure the size of the ablation zone and to calculate the ablation margin...
January 2018: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/29312649/microwave-ablation-versus-radiofrequency-ablation-for-the-treatment-of-pulmonary-tumors
#18
Feng Shi, Guangxiao Li, Zejian Zhou, Rongde Xu, Weike Li, Wenhang Zhuang, Zide Chen, Xiaoming Chen
To retrospectively compare the efficacy and safety of radiofrequency ablation (RFA) and microwave ablation (MWA) in the treatment of pulmonary tumors, a total of 75 patients with lung tumor who underwent thermal ablation therapy in Guangdong General Hospital into the study from March 2007 to December 2014 were enrolled. Of the patients, 43 received radiofrequency ablation and 32 received microwaves ablation. The response rates, overall survival (OS), and complications rates between the RFA group and MWA group were compared...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29250732/residue-characteristics-of-sludge-from-a-chemical-industrial-plant-by-microwave-heating-pyrolysis
#19
Kuo-Hsiung Lin, Nina Lai, Jun-Yan Zeng, Hung-Lung Chiang
Sludge from biological wastewater treatment procedures was treated using microwave heating pyrolysis to reduce the environmental impact of a chemical plant. In this study, major elements, trace elements, PAHs and nitro-PAHs in raw sludge, and pyrolysis residues were investigated. The contents of major element from raw sludge were carbon 46.7 ± 5.9%, hydrogen 5.80 ± 0.58%, nitrogen 6.81 ± 0.59%, and sulfur 1.34 ± 0.27%. Trace elemental concentrations including Zn, Mn, Cr, Cd, As, and Sn were 0.410 ± 0...
March 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29225619/clinical-application-of-ct-guided-percutaneous-microwave-ablation-for-the-treatment-of-lung-metastasis-from-colorectal-cancer
#20
Lin Li, Ketong Wu, Haiyang Lai, Bo Zhang
Objective: The aim of our research is to explore the clinical efficacy and safety of CT-guided percutaneous microwave ablation (MWA) for the treatment of lung metastasis from colorectal cancer. Materials and Methods: CT-guided percutaneous MWA was performed in 22 patients (male 14, female 8, mean age: 56.05 ± 12.32 years) with a total of 36 lung metastatic lesions from colorectal cancer between February 2014 and May 2017. Clinical data were retrospectively analyzed with respect to the efficacy, safety, and outcome...
2017: Gastroenterology Research and Practice
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