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microwave lung

George A Carberry, Elisabetta Nocerino, Peter J Mason, Denise J Schwahn, Scott Hetzel, Alyssa M Turnquist, Fred T Lee, Christopher L Brace
Purpose To determine how close to the heart pulmonary microwave ablation can be performed without causing cardiac tissue injury or significant arrhythmia. Materials and Methods The study was performed with approval from the institutional animal care and use committee. Computed tomographic fluoroscopically guided microwave ablation of the lung was performed in 12 swine. Antennas were randomized to either parallel (180° ± 20°) or perpendicular (90° ± 20°) orientation relative to the heart surface and to distances of 0-10 mm from the heart...
October 12, 2016: Radiology
Jacob Freedman, Piotr Harbut
This is a case report of microwave energy being used to ablate an inoperable metastasis of a Wilms' tumour in a 6-year-old boy using state-of-the-art navigated computed tomography targeting and high-frequency jet ventilation to reduce organ displacement and the potential risk of procedure-related pneumothorax. After the ablation, the young boy had high-dose chemotherapy followed by an autologous stem cell transplantation with rapid reduction of three recurrent right-sided lung metastases.
May 2016: Case Reports in Oncology
T de Baere, L Tselikas, V Catena, X Buy, F Deschamps, J Palussière
Percutaneous ablation of small-size non-small-cell lung cancer (NSCLC) has demonstrated feasibility and safety in nonsurgical candidates. Radiofrequency ablation (RFA), the most commonly used technique, has an 80-90% reported rate of complete ablation, with the best results obtained in tumors less than 2-3cm in diameter. The highest one-, three-, and five-year overall survival rates reported in NSCLC following RFA are 97.7%, 72.9%, and 55.7% respectively. Tumor size, tumor stage, and underlying comorbidities are the main predictors of survival...
October 2016: Diagnostic and Interventional Imaging
Thomas J Vogl, Romina Eckert, Nagy N N Naguib, Martin Beeres, Tatjana Gruber-Rouh, Nour-Eldin A Nour-Eldin
OBJECTIVE: The purpose of this study is to retrospectively evaluate local tumor control, time to tumor progression, and survival rates among patients with lung metastatic colorectal cancer who have undergone ablation therapy performed using laser-induced thermotherapy (LITT), radiofrequency ablation (RFA), or microwave ablation (MWA). MATERIALS AND METHODS: Data for this retrospective study were collected from 231 CT-guided ablation sessions performed for 109 patients (71 men and 38 women; mean [± SD] age, 68...
September 28, 2016: AJR. American Journal of Roentgenology
F M Gur, S Timurkaan
Androgens exert their effects through androgen receptors (AR) in tissues. We investigated the distribution of AR in female mole rat tissues. Tissues were excised, fixed with 10% formalin and embedded in paraffin. Sections were stained after microwave antigen retrieval for immunohistochemistry. Immunostaining of AR immunostaining was detected in the nucleus or cytoplasm of the cells in the cerebral cortex, cerebellum, anterior pituitary, lung, liver, uterus and skin. Granulosa and some thecal cells in the ovary, cardiac muscle cells and adipose cells exhibited a nuclear reaction for AR...
October 2016: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
Saurabh Singh, Steven Bandula, Jeremy Brown, Jeremy Whelan, Rowland Illing
We present a case of a patient who following chemotherapy developed semi-invasive pulmonary aspergillosis and an aspergilloma in a lung cavity previously formed by microwave ablation (MWA). A 55-year-old woman presented with cough and shortness of breath after finishing three cycles of chemotherapy for a metastatic nerve sheath tumour. She had been treated by MWA for pulmonary metastases 2 years previously which resulted in a residual right apical lung cavity. Postchemotherapy imaging showed that this cavity had enlarged, developed a thicker wall and contained lobulated soft tissue with a crescent sign on coronal reformats...
2016: BMJ Case Reports
Galal Elgemeie, Mamdouh Abu-Zaied, Ali Hebishy, Nermen Abbas, Mai Hamed
A first microwave-assisted synthesis of a new class of novel purine thioglycoside analogs from readily available starting materials has been described. The key step of this protocol is the formation of sodium pyrazolo[1,5-a]pyrimidine-7-thiolate and 7-mercaptopyrazolo[1,5-a]pyrimidine derivatives via condensation of 5-amino-1H-pyrazoles with sodium 2,2-dicyanoethene-1,1-bis(thiolate) salts or 2-(dimercaptomethylene)malononitrile, respectively, under microwave irradiation, followed by coupling with halo sugars to give the corresponding purine thioglycoside analogs...
September 2016: Nucleosides, Nucleotides & Nucleic Acids
N Parvizi, D Chung, M W Little, F V Gleeson, E M Anderson
AIM: To assess the clinical utility of perfusion computed tomography (pCT) parameters in microwave ablation (MWA) of lung tumours. MATERIALS AND METHODS: Patients were included who had primary or metastatic lung tumours and underwent pCT studies immediately pre- and post-MWA. Perfusion maps of the tumours were constructed using CT perfusion software (GE, Milwaukee, WI, USA). Regions of interest were drawn on sequential axial sections to extract the pCT parameters, blood volume (BV), average blood flow (BF), and mean transit time (MTT) from the entire tumour volume...
November 2016: Clinical Radiology
Rupinder Kaur Gill, Virender Kumar, Mahendra Bishnoi, Kamalendra Yadav, Kanthi Kiran Kondepudi, Jitender Bariwal
4-Substituted thieno[2,3-d]pyrimidines have been synthesized via microwave-assisted methods and screened for their cytotoxic activity against liver HepG-2, lung NCI-H522, melanoma A-375, pancreatic MIA PaCa-2 and colon CaCo-2 human cancer cell lines using MTT assay. The antiproliferative potential of most active compounds 20b and 20f (piperidino substituted); and 22d (hybrid analogue of Dasatinib) was further assessed and confirmed by calcein AM and colony formation assay, which revealed the higher potency of hybrid analogue 22d in comparison to piperidino substituted derivative 20f...
August 17, 2016: Anti-cancer Agents in Medicinal Chemistry
Ti Zhang, Shuang Cai, Wai Chee Forrest, Eva Mohr, Qiuhong Yang, M Laird Forrest
Cisplatin, a platinum chemotherapeutic, is one of the most commonly used chemotherapeutic agents for many solid tumors. In this work, we developed and validated an inductively coupled plasma mass spectrometry (ICP-MS) method for quantitative determination of platinum levels in rat urine, plasma, and tissue matrices including liver, brain, lungs, kidney, muscle, heart, spleen, bladder, and lymph nodes. The tissues were processed using a microwave accelerated reaction system (MARS) system prior to analysis on an Agilent 7500 ICP-MS...
September 2016: Applied Spectroscopy
Huiqiang Wang, Qinfeng Rong, Zhanfang Ma
Polyhydroquinone-graphene composite as a new redox species was synthesized simply by a microwave-assisted one-pot method through oxidative polymerization of hydroquinone by graphene oxide, which exhibited excellent electrochemical redox activity at 0.124 V and can remarkably promote electron transfer. The as-prepared composite was used as immunosensing substrate in a label-free electrochemical immunosensor for the detection of cytokeratins antigen 21-1, a kind of biomarker of lung cancer. The proposed immunosensor showed wide liner range from 10 pg mL(-1) to 200 ng mL(-1) with a detection limit 2...
2016: Scientific Reports
Senthil Kumar C, Sivakumar M, Ruckmani K
Response Surface Methodology (RSM) was used to optimize the parameters for microwave-assisted extraction of polysaccharides from Cyphomandra betacea. The results showed a good fit with a second-order polynomial equation that was statistically acceptable at P<0.05. Optimal conditions for the extraction of polysaccharides were: extraction time, 2h; microwave power, 400W; extraction temperature, 60°C; and ratio of raw material to water 1:40 (g/mL). Under the optimized conditions, the yield of polysaccharides was found to be relatively high (about 36...
November 2016: International Journal of Biological Macromolecules
Nataša Perin, Raja Nhili, Maja Cindrić, Branimir Bertoša, Darko Vušak, Irena Martin-Kleiner, William Laine, Grace Karminski-Zamola, Marijeta Kralj, Marie-Hélène David-Cordonnier, Marijana Hranjec
We describe the synthesis, 3D-derived quantitative structure-activity relationship (QSAR), antiproliferative activity and DNA binding properties of a series of 2-amino, 5-amino and 2,5-diamino substituted benzimidazo[1,2-a]quinolines prepared by environmentally friendly uncatalyzed microwave assisted amination. The antiproliferative activities were assessed in vitro against colon, lung and breast carcinoma cell lines; activities ranged from submicromolar to micromolar. The strongest antiproliferative activity was demonstrated by 2-amino-substituted analogues, whereas 5-amino and or 2,5-diamino substituted derivatives resulted in much less activity...
October 21, 2016: European Journal of Medicinal Chemistry
Zhigang Wei, Xin Ye, Xia Yang, Guanghui Huang, Wenhong Li, Jiao Wang, Xiaoying Han, Min Meng, Yang Ni
OBJECTIVES: To verify the association between EGFR status and clinical response to microwave ablation (MWA) and survival. METHODS: NSCLC patients with known EGFR status and treated with MWA in combination with chemotherapy were retrospectively enrolled in the study. RESULTS: A total of 61 patients were recruited. EGFR mutations were found in 28 patients (39.4 %), and were more common in women (67.7 %) and nonsmokers (74.1 %). Complete ablation was achieved in 69...
July 19, 2016: European Radiology
Ayo Zaccheaus Ibitoye, Ephraim Okeke Nwoye, Adebayo Moses Aweda, Ademola A Oremosu, Chidozie Charles Anunobi, Nurudeen Olanrewaju Akanmu
PURPOSE: To study the efficiency of a dual slot antenna with a floating metallic sleeve on the ablation of different ex-vivo bovine tissues Materials and Methods: COMSOL Multiphysics® version 4.4 which is based on finite element methods (FEM) was used to design and simulate monopole and dual slot antennas with sleeve. Power, specific absorption rate (SAR), temperature and necrosis distributions in the selected tissues were determined using these antennas. Monopole and dual slot with sleeve antennas were designed, simulated, constructed and applied in this study based on semi-rigid coaxial cable...
July 18, 2016: International Journal of Hyperthermia
L Sidoff, D E Dupuy
Approximately 30% of early stage lung cancer patients are not surgical candidates due to medical comorbidities, poor cardiopulmonary function and advanced age. These patients are traditionally offered chemotherapy and radiation, which have shown relatively modest improvements in mortality. For over a decade, percutaneous image-guided ablation has emerged as a safe, cost-effective, minimally invasive treatment alternative for patients who would otherwise not qualify for surgery. Although radiofrequency ablation (RFA) is currently the most extensively studied and widely utilized technique in the treatment of lung malignancies there is a growing body of evidence that microwave ablation (MWA) has several unique benefits over RFA and cryoablation in the lung...
July 13, 2016: International Journal of Hyperthermia
Jan Sebek, Sergio Curto, Radoslav Bortel, Punit Prakash
PURPOSE: Microwave ablation (MWA) applicators capable of creating directional heating patterns offer the potential of simplifying treatment of targets in proximity to critical structures and avoiding the need for piercing the tumour volume. This work reports on improved directional MWA antennas with the objectives of minimising device diameter for percutaneous use (≤ ∼13 gauge) and yielding larger ablation zones. METHODS: Two directional MWA antenna designs, with a modified monopole radiating element and spherical and parabolic reflectors are proposed...
July 5, 2016: International Journal of Hyperthermia
Ildikó Lung, Maria-Loredana Soran, Ocsana Opriş, Mihail Radu Cătălin Truşcă, Ülo Niinemets, Lucian Copolovici
Exposure to sustained low intensity microwaves can constitute a stress for the plants, but its effects on plant secondary chemistry are poorly known. We studied the influence of GSM and WLAN-frequency microwaves on emissions of volatile organic compounds and content of essential oil in the aromatic plant Ocimum basilicum L. hypothesizing that microwave exposure leads to enhanced emissions of stress volatiles and overall greater investment in secondary compounds. Compared to the control plants, microwave irradiation led to decreased emissions of β-pinene, α-phellandrene, bornyl acetate, β-myrcene, α-caryophyllene and benzaldehyde, but increased emissions of eucalyptol, estragole, caryophyllene oxide, and α-bergamotene...
November 1, 2016: Science of the Total Environment
Chun-Lung Yuan, Shih-Wei Lin, Meng-Hsuan Cheng
BACKGROUND: According to a review of recent literature, no previous studies have reported the dose-dependent selective inhibition of the antiproliferative activity using colony and sphere formation assays and immunoblotting in human hepatoma cells in response to doxorubicin and mitoxantrone structural analogs such as AM3. OBJECTIVE: We evaluated the anticancer activity of mitoxantrone (MIT) structural analogs 1,5-bis({2-[(2-hydroxyethyl) amino]ethyl}-amino)-anthracene-9,10-dione (AM3) in human hepatoma cells (Huh-7)...
June 22, 2016: Medicinal Chemistry
Naoki Ohyabu, Kiyoshi Kakiya, Yasuhiro Yokoi, Hiroshi Hinou, Shin-Ichiro Nishimura
Synthetic macromolecular MUC1 glycopeptides have been used to unravel molecular mechanisms in antibody recognition of disease-specific epitopes. We have established a novel synthetic strategy for MUC1 tandem repeats having complex O-glycosylation states at each repeating unit based on convergent solid-phase fragment condensation under microwave irradiation. We have accomplished the synthesis of 77 amino acid MUC1 glycopeptides (MW = 12 759) having three major antigenic O-glycoforms [Tn, core 1 (T), and core 2 structures] at 10 designated positions out of 19 potential O-glycosylation sites...
July 13, 2016: Journal of the American Chemical Society
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