Daiki Hokkoku, Kazuki Sasaki, Shogo Kobayashi, Takashi Shimbo, Tomomi Kitayama, Sho Yamazaki, Yukari Yamamoto, Yuya Ouchi, Hiroki Imamura, Takeshi Kado, Keisuke Toya, Wataru Fujii, Yoshifumi Iwagami, Daisaku Yamada, Yoshito Tomimaru, Takehiro Noda, Hidenori Takahashi, Katsuto Tamai, Yuichiro Doki, Hidetoshi Eguchi
BACKGROUND: Chronic pancreatitis (CP) is a progressive disease characterized by pancreatic fibrosis for which effective treatment options are lacking. Mesenchymal stem cells (MSCs) have shown potential for fibrosis treatment but face limitations in clinical application. The high-mobility group box 1 (HMGB1) fragment mobilizes MSCs from bone marrow into the blood and has emerged as a promising therapeutic agent for tissue regeneration in various pathological conditions. The aim of this study was to investigate the potential therapeutic effects of systemic administration of the HMGB1 fragment in a mouse model of CP...
May 10, 2024: Journal of Gastroenterology