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Bone sarcomas

Iveta Oravcova, Eva Mikuskova, Michaela Leitnerova, Jan Gyarfas, Andrea Mlcakova, Peter Szepe, Lukas Plank, Ludmila Demitrovicova, Vanda Mikudova, Silvia Cingelova, Michal Mego, Lubos Drgona
Myeloid sarcoma is a rare presentation of acute leukemia as a solid tumor at various extramedullary sites. It may present concurrently, before or after the onset of systemic bone marrow leukemia. Unusual clinical localization may lead to misdiagnosis, or delayed diagnosis and treatment. We describe the first case, to our knowledge, of de novo myeloid sarcoma of the breast confirmed as acute promyelocytic leukemia. Immunohistochemical analysis, flow cytometry, fluorescent in situ hybridization analysis and molecular analysis using RQ-PCR of tissue samples should be routine in determining the correct diagnosis in this setting...
June 21, 2018: International Journal of Hematology
Jonathan D Stevenson, Minna K Laitinen, Michael C Parry, Vaiyapuri Sumathi, Robert J Grimer, Lee M Jeys
INTRODUCTION: Chondrosarcoma (CS) is the second most common primary bone sarcoma with no clear role for adjuvant therapy. The purpose of this study was to investigate (1) the relationship between surgical excision margins and local recurrence free survival (LRFS), and (2) the role of local recurrence (LR) in disease specific survival (DSS) in CS of the extremity and pelvis. MATERIAL AND METHODS: 341 pelvic and extremity CS diagnosed between 2003 and 2015 were studied retrospectively...
June 8, 2018: European Journal of Surgical Oncology
Chuanxi Zheng, Wei You, Peng Wan, Xiaochun Jiang, Jinquan Chen, Yuchen Zheng, Wei Li, Jifeng Tan, Shiquan Zhang
Programmed cell death-ligands 1 (PD-L1) is a key immune checkpoint protein and a promising therapeutic target for malignancy tumor immunotherapy. The prognostic value of PD-L1 in patients with bone and soft tissue sarcoma remains controversial. Therefore, this meta-analysis is conducted to evaluate the associations of PD-L1 expression with overall survival (OS), progression-free survival (PFS), and clinicopathological characteristics of sarcomaA comprehensive literature search of PubMed, Web of Science, Embase, and Cochrane Library was conducted for relevant studies...
June 2018: Medicine (Baltimore)
Yi-Ming Ren, Yuan-Hui Duan, Yun-Bo Sun, Tao Yang, Wen-Jun Zhao, Dong-Liang Zhang, Zheng-Wei Tian, Meng-Qiang Tian
BACKGROUND: Human osteosarcoma (OS) is one of the most common primary bone sarcoma, because of early metastasis and few treatment strategies. It has been reported that the tumorigenicity and self-renewal capacity of side population (SP) cells play roles in human OS via regulating of target genes. This study aims to complement the differentially expressed genes (DEGs) that regulated between the SP cells and the non-SP cells from primary human OS and identify their functions and molecular pathways associated with OS...
June 19, 2018: Journal of Orthopaedic Surgery and Research
Shunichi Toki, Susumu Wakai, Masaya Sekimizu, Taisuke Mori, Hitoshi Ichikawa, Akira Kawai, Akihiko Yoshida
AIMS: Ewing sarcoma is a small round cell tumor that affects bone and soft tissues. Although the detection of the specific fusion gene is a robust method of its diagnosis, immunohistochemistry may serve as a practical surrogate. Recent tissue microarray studies suggested that PAX7 is a novel marker, because it was consistently expressed in Ewing sarcoma, in addition to rhabdomyosarcoma and synovial sarcoma. Here, we evaluated the utility of PAX7 immunohistochemistry in whole-tissue sections of an expanded array of round cell malignancies with adequate molecular characterization...
June 19, 2018: Histopathology
Amélie Poidvin, Jean-Claude Carel, Emmanuel Ecosse, Dominique Levy, Jean Michon, Joël Coste
The association between growth hormone (GH) treatment and cancer risk has not been thoroughly evaluated and there are questions about any increased risk of bone tumors. We examined cancer risk and especially bone tumor risk in a population-based cohort study of 6874 patients treated with recombinant GH in France for isolated GH deficiency, short stature associated with low birth weight or length or idiopathic short stature. Adult mortality and morbidity data obtained from national databases and from questionnaires...
June 14, 2018: Cancer Medicine
Francisco Giner, José A López-Guerrero, Antonio Fernández-Serra, Isidro Machado, Empar Mayordomo-Aranda, Amando Peydró-Olaya, Antonio Llombart-Bosch
Background Ewing sarcoma (EWS) is the second most common bone cancer in pediatric patients. Angiogenesis is a major factor for tumor growth and metastasis. Our aim was to carry out a histological, immunohistochemical, and molecular characterization of the neovascularization established between xenotransplanted tumors and the host during the initial phases of growth in nude mice in three angiogenesis experiments (ES2, ES3, and ES4). Methods The original human EWS were implanted subcutaneously on the backs of three nude mice...
January 1, 2018: Pediatric and Developmental Pathology
Manoj Kumar Panigrahi, Gourahari Pradhan, Nibedita Sahoo, Pritinanda Mishra, Susama Patra, Prasanta Raghab Mohapatra
Synovial sarcoma (SS) is a malignant mesenchymal tumor with variable epithelial differentiation that affects mostly young adults and can arise at any anatomic site. Primary intrathoracic SS is very rare accounting for <0.5% of all lung tumors. Most commonly, it arises from the lung followed by pleura and mediastinum. Primary pulmonary SS (PPSS) affects both sexes equally with no preference for any hemithorax. The morphology, immunostaining properties, cytogenetic features, and management strategy of PPSS are similar to that of soft tissue SS...
April 2018: Journal of Cancer Research and Therapeutics
Kourosh Goudarzipour, Farzaneh Farahmandi, Ahmad Mohammadi, Reza Taherian
Ewing sarcoma/peripheral primitive neuroectodermal tumor (ES/PNET) typically occurs in long or flat bones, soft tissues, or less often, solid organs. Ewing sarcoma/peripheral primitive neuroectodermal tumor arising from the adrenal gland is extremely rare, especially in children, and only limited cases are reported previously. Herein, we review a case of a 22-month-old girl who presented to our department with abdominal pain, bulging of the left flank, and a nonfunctioning adrenal lesion which was found to be an adrenal ES/PNET...
May 2018: Iranian Journal of Kidney Diseases
Juho T K Salo, Erkki J Tukiainen
OBJECTIVE: The study aim was to analyse chest wall reconstruction following oncological resection by a single surgeon over an 19 year period. METHODS: A retrospective review was performed for 135 patients who underwent oncological chest wall resection during 1997-2015. RESULTS: Average patient age was 57.8 years. Indications for resection were: advanced breast cancer n=44, soft tissue sarcoma n=38, bone or chondrosarcoma n=28, desmoid tumour n=11, metastasis from other cancers n=7, and other primary tumours n=7...
May 22, 2018: Plastic and Reconstructive Surgery
Joana Ruivo Rodrigues, Manuel João Brito, Rui Pedro Faria Pais, Sílvia Carvalho
Myeloid sarcoma (MS), granulocytic sarcoma or chloroma, is defined as a localized extramedullary mass of blasts of granulocytic lineage with or without maturation, occurring outside the bone marrow. MS can be diagnosed concurrently with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). The authors report a case of sacral MS occurring as a relapse of myeloid leukemia in a 5-year-old girl who was taken to the emergency department with radiculopathy symptoms.
2018: Case Reports in Radiology
Jacek Wachowiak, Alicja Chybicka, Jerzy R Kowalczyk, Mariusz Wysocki, Jolanta Goździk, Ewa Gorczyńska, Krzysztof Kałwak, Jan Styczyński, Katarzyna Drabko, Anna Pieczonka
The purpose of the survey was to evaluate the development and current use of hematopoietic stem cell transplantation (HSCT) in Poland between 1989-2016. The data for analysis (indication, number of performed HSCT, HSCT type, donor type, and stem cell source, year) have been collected annually using a standardized form. In Poland, between 1989-2016, the number of pediatric transplant beds grew from one to 40 and number and rate of transplants increased annually from 1/year (0.8/10 million) to 186/year (248/10 million)...
May 16, 2018: Transfusion and Apheresis Science
Nirmalya Sen, Allison M Cross, Philip L Lorenzi, Javed Khan, Berkley E Gryder, Suntae Kim, Natasha J Caplen
Ewing sarcoma (EWS) is a soft tissue and bone tumor that occurs primarily in adolescents and young adults. In most cases of EWS, the chimeric transcription factor, EWS-FLI1 is the primary oncogenic driver. The epigenome of EWS cells reflects EWS-FLI1 binding and activation or repression of transcription. Here, we demonstrate that EWS-FLI1 positively regulates the expression of proteins required for serine-glycine biosynthesis and uptake of the alternative nutrient source glutamine. Specifically, we show that EWS-FLI1 activates expression of PHGDH, PSAT1, PSPH, and SHMT2...
June 6, 2018: Molecular Carcinogenesis
Jijun Liu, Qi Wu, Yonggui Wang, Yulong Wei, Hong Wu, Lijun Duan, Qiang Zhang, Yonggang Wu
Purpose: Osteosarcoma (OS) is the most common type of primary solid bone tumor. Ovo-like zinc finger 2 (Ovol2), a zinc finger transcription factor, is a mesenchymal-epithelial transition (MET) driver that induces miR-200 expression in prostate cancer, breast cancer, and hepatocellular carcinoma. However, little is known about the expression and function of MET in sarcomas, including OS. This study investigated the expression and clinicopathological significance of Ovol2 and its effect on MET in OS...
2018: OncoTargets and Therapy
Yasushi Ishida, Miho Maeda, Souichi Adachi, Hiroko Inada, Hiroshi Kawaguchi, Hiroki Hori, Atsushi Ogawa, Kazuko Kudo, Chikako Kiyotani, Hiroyuki Shichino, Takeshi Rikiishi, Ryoji Kobayashi, Maho Sato, Jun Okamura, Hiroaki Goto, Atsushi Manabe, Shinji Yoshinaga, Dongmei Qiu, Junichiro Fujimoto, Tatsuo Kuroda
BACKGROUNDS: Multidisciplinary therapy has increased the risk of subsequent late effects, but detailed analyses on secondary cancers in childhood cancer survivors (CCSs) are limited in Asian countries. METHODS: This was a retrospective cohort study comprising 10,069 CCSs who were diagnosed between 1980 and 2009 across 15 Japanese hospitals. We conducted secondary analyses to estimate the incidence of secondary cancer according to each primary malignancy and to elucidate the association between primary and secondary cancers...
June 5, 2018: International Journal of Clinical Oncology
Fanny Chapelin, Aman Khurana, Mohammad Moneeb, Florette K Gray Hazard, Chun Fai Ray Chan, Hossein Nejadnik, Dita Gratzinger, Solomon Messing, Jason Erdmann, Amitabh Gaur, Heike E Daldrup-Link
PURPOSE: While imaging matrix-associated stem cell transplants aimed for cartilage repair in a rodent arthritis model, we noticed that some transplants formed locally destructive tumors. The purpose of this study was to determine the cause for this tumor formation in order to avoid this complication for future transplants. PROCEDURES: Adipose-derived stem cells (ADSC) isolated from subcutaneous adipose tissue were implanted into 24 osteochondral defects of the distal femur in ten athymic rats and two immunocompetent control rats...
June 4, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
Marc G Stevenson, Harald J Hoekstra, Wangzhao Song, Albert J H Suurmeijer, Lukas B Been
INTRODUCTION: This study aims to evaluate the applicability and prognostic value of the European Organization for Research and Treatment of Cancer-Soft Tissue and Bone Sarcoma Group (EORTC-STBSG) histopathological response score in extremity soft tissue sarcoma (ESTS) patients treated with neoadjuvant hyperthermic isolated limb perfusion (HILP) and delayed surgical resection. METHODS: Patients treated between 1991 and 2016 were included. The histopathological tumor response was established in accordance with the EORTC-STBSG response score...
May 16, 2018: European Journal of Surgical Oncology
Leilei Xu, Zheng Tian, Akbar Yunus, Xiaoshuai Wang, Jiangtao Chen, Chong Wang, Xinghua Song
Objective: To discuss the effect of three-dimensional (3D) printing individualized model and guide plate in bone tumor surgery. Methods: Between October 2015 and December 2016, 3D printing individualized model and guide plate for making preoperative surgical planning and intraoperative treatment were used in 5 patients of bone tumor. All the patients were male, with a median age of 32 years (range, 9-58 years). There were 1 case of cystic echinococcosis at left pelvis and pathological fracture of the proximal femur; 1 case of left iliac bone osteoblastoma associated with aneurysmal bone cyst; 1 case of fibrous dysplasia of the left femur (sheep horn deformity) with pathological fracture; 1 case of metastatic carcinoma of right calcaneus (tumor staging was T 2 N 0 M 0 ); and 1 case of Ewing sarcoma of left femur (tumor staging was T 2 N 0 M 0 )...
September 1, 2017: Chinese Journal of Reparative and Reconstructive Surgery
Camille Jacques, Nathalie Renema, Frederic Lezot, Benjamin Ory, Carl R Walkley, Agi E Grigoriadis, Dominique Heymann
Osteosarcoma, Ewing sarcoma and chondrosarcoma are the three main entities of bone sarcoma which collectively encompass more than 50 heterogeneous entities of rare malignancies. In contrast to osteosarcoma and Ewing sarcoma which mainly affect adolescents and young adults and exhibit a high propensity to metastasise to the lungs, chondrosarcoma is more frequently observed after 40 years of age and is characterised by a high frequency of local recurrence. The combination of chemotherapy, surgical resection and radiotherapy has contributed to an improved outcome for these patients...
September 2018: Journal of Bone Oncology
Leonardo Horbach, Marialva Sinigaglia, Camila Alves Da Silva, Danielly Brufatto Olguins, Lauro José Gregianin, Algemir Lunardi Brunetto, André Tesainer Brunetto, Rafael Roesler, Caroline Brunetto De Farias
Ewing Sarcoma (ES) is a highly aggressive bone and soft tissue childhood cancer. The development of resistance to chemotherapy is common and remains the main cause of treatment failure. We herein evaluated the expression of genes associated with chemotherapy resistance in ES cell lines. A set of genes (CCAR1, TUBA1A, POLDIP2, SMARCA4 and SMARCB1) was data-mined for resistance against doxorubicin and vincristine, which are the standard drugs used in the treatment of patients with ES. The expression of each gene in SK-ES-1 ES cells was reported before and after exposure to a drug resistance-inducing protocol...
June 2018: Molecular and Clinical Oncology
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