keyword
https://read.qxmd.com/read/38021739/global-trends-and-hotspots-in-research-on-tooth-agenesis-a-20-year-bibliometric-analysis
#21
REVIEW
Bo Xie, Ying Han, Xiujie Wen
Tooth agenesis, one of the most common developmental defects in humans, not only impairs oral function but can also lead to craniofacial deformities. Bibliometric analysis can reveal significant shifts in research and publishing trends within specific fields. This study aims to provide a comprehensive overview of the research hotspots in tooth agenesis and predict future trends through bibliometric analysis. We searched for English-language publications related to tooth agenesis from 2001 to 2021 on the Web of Science...
October 2023: Curēus
https://read.qxmd.com/read/38013205/lrp4-mutations-dental-anomalies-and-oral-exostoses
#22
JOURNAL ARTICLE
Piranit Kantaputra, Weena Panichkul, Parisri Sillapasorn, Ploy Adisornkanj, Panita Kitsadayurach, Massupa Kaewgaya, Worrachet Intachai, Bjorn Olsen, Chumpol Ngamphiw, Chidchanok Leethanakul, Peeranat Jatooratthawichot, James R Ketudat Cairns, Sissades Tongsima
BACKGROUND: In order to generate a normal set of teeth, fine-tuning of Wnt/β-catenin signaling is required, in which WNT ligands bind to their inhibitors or WNT inhibitors bind to their co-receptors. Lrp4 regulates the number of teeth and their morphology by modulating Wnt/β-catenin signaling as a Wnt/β-catenin activator or inhibitor, depending on its interactions with the partner proteins, such as Sostdc1 and Dkk1. AIM: To investigate genetic etiologies of dental anomalies involving LRP4 in a Thai cohort of 250 children and adults with dental anomalies...
November 27, 2023: International Journal of Paediatric Dentistry
https://read.qxmd.com/read/37978489/associations-across-22-dental-and-craniovertebral-anomalies%C3%A2-or%C3%A2-variations-sagittal-skeletal-relationships-and-vertical-growth-patterns-a-comprehensive-epidemiological-study-of-43-dentoskeletal-traits
#23
JOURNAL ARTICLE
Farhad Sobouti, Sepideh Dadgar, Parsa Goleyjani, Vahid Rakhshan
INTRODUCTION: Despite researchers' recent interest in identifying links between some dental and craniovertebral abnormalities, there are many important, unassessed gaps in our knowledge of this matter. In addition, previous samples were small. This large study aimed to examine, for the first time, the occurrence/severity of numerous dental and skeletal anomalies or variations and their correlations with each other and with growth patterns. METHODS: This epidemiological study was conducted on pretreatment radiographs of 1194 patients from 3 cities (815 females)...
November 17, 2023: BMC Oral Health
https://read.qxmd.com/read/37974060/case-report-neuropsychological-assessment-in-a-patient-with-4h-leukodystrophy
#24
JOURNAL ARTICLE
Aya Haneda, Jennifer K Hoots, Hannah A Hagy, Maureen Lacy
Objective: POLR3-HLD or 4H leukodystrophy is an autosomal recessive disorder characterized by hypomyelination, hypodontia, and hypogonadotropic hypogonadism, and caused by variants in POLR3A , POLR3B , POLR1C , or POLR3K genes. Neurological and non-neurological clinical features and disease severity vary. While previous studies reference variable cognition, this is the first report of 4H detailing a comprehensive neuropsychological assessment. Method: The current study presents a 20-year-old, English-speaking, right-handed, non-Hispanic White female with 12 years of education with genetically confirmed 4H POLR3B -related leukodystrophy without hormonal replacement treatment...
November 16, 2023: Clinical Neuropsychologist
https://read.qxmd.com/read/37951521/arthrogryposis-multiplex-congenita-dental-and-maxillofacial-phenotype-a-scoping-review
#25
REVIEW
Doaa Taqi, Shahrzad Nematollahi, Sarah Lemin, Frank Rauch, Reggie Hamdy, Noemi Dahan-Oliel
INTRODUCTION: Arthrogryposis multiplex congenita (AMC) is a heterogeneous group of disorders associated with decreased fetal movement, with a prevalence between 1/3000 and 1/5200 live births. Typical features of AMC include multiple joint contractures present at birth, and can affect all joints of the body, from the jaw, and involving the upper limbs, lower limbs and spine. The jaws may be affected in 25 % of individuals with AMC, with limited jaw movement and mouth opening. Other oral and maxillofacial deformities may be present in AMC, including cleft palate, micrognathia, periodontitis and delayed teething...
November 9, 2023: Bone
https://read.qxmd.com/read/37945889/correction-to-the-role-of-the-general-dental-practitioner-in-the-management-of-the-hypodontia-patient
#26
(no author information available yet)
No abstract text is available yet for this article.
November 2023: British Dental Journal
https://read.qxmd.com/read/37943264/hypohidrotic-ectodermal-dysplasia-milia-treatment-with-fractional-carbon-dioxide-laser-and-laser-assisted-drug-delivery-of-triamcinolone
#27
JOURNAL ARTICLE
Jessica Mineroff, Jessica R Dowling, Nicole M Golbari, Todd Wechter, Jared Jagdeo
Hypohidrotic ectodermal dysplasia (HED) is a genetic disorder characterized by hypohidrosis, hypodontia, and hypotrichosis. Skin manifestations, including dyspigmentation and milia-like papules that coalesce into plaques, are difficult to treat. There is no cure for HED, therefore treatment is focused on managing symptoms and improving quality of life. There is limited evidence in the literature for safe and effective treatments improving HED-related facial skin aesthetics. The facial skin rashes caused by HED demonstrate an unmet clinical need in dermatology...
November 1, 2023: Journal of Drugs in Dermatology: JDD
https://read.qxmd.com/read/37915380/biallelic-pathogenic-variants-in-polr3d-alter-trna-transcription-and-cause-a-hypomyelinating-leukodystrophy-a-case-report
#28
Julia Macintosh, Stefanie Perrier, Maxime Pinard, Luan T Tran, Kether Guerrero, Chitra Prasad, Asuri N Prasad, Tomi Pastinen, Isabelle Thiffault, Benoit Coulombe, Geneviève Bernard
RNA polymerase III-related leukodystrophy (POLR3-related leukodystrophy) is a rare, genetically determined hypomyelinating disease arising from biallelic pathogenic variants in genes encoding subunits of RNA polymerase III (Pol III). Here, we describe the first reported case of POLR3-related leukodystrophy caused by biallelic pathogenic variants in POLR3D , encoding the RPC4 subunit of Pol III. The individual, a female, demonstrated delays in walking and expressive and receptive language as a child and later cognitively plateaued...
2023: Frontiers in Neurology
https://read.qxmd.com/read/37894742/count-me-in-count-me-out-regulation-of-the-tooth-number-via-three-directional-developmental-patterns
#29
REVIEW
Zheng Fang, Devi Atukorallaya
Tooth number anomalies, including hyperdontia and hypodontia, are common congenital dental problems in the dental clinic. The precise number of teeth in a dentition is essential for proper speech, mastication, and aesthetics. Teeth are ectodermal organs that develop from the interaction of a thickened epithelium (dental placode) with the neural-crest-derived ectomesenchyme. There is extensive histological, molecular, and genetic evidence regarding how the tooth number is regulated in this serial process, but there is currently no universal classification for tooth number abnormalities...
October 11, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37865729/is-there-an-association-between-molar-incisor-hypomineralization-and-developmental-dental-anomalies-a-case-control-study
#30
JOURNAL ARTICLE
Betül Şen Yavuz, Berkant Sezer, Remziye Kaya, Nihan Tuğcu, Betül Kargül
BACKGROUND: The aim of this study was to determine whether there is any association between molar incisor hypomineralization and developmental dental anomalies. METHODS: Two pediatric dentists evaluated panoramic radiographs of 429 children aged 8-14 years with molar incisor hypomineralization (study group) and 437 children without molar incisor hypomineralization (control group) in terms of developmental dental anomalies. Twelve different developmental dental anomalies were categorized into four types: size (microdontia, macrodontia); position (ectopic eruption of maxillary permanent first molars, infraocclusion of primary molars); shape (fusion, gemination, dilaceration, taurodontism, peg-shaped maxillary lateral incisors); and number (hypodontia, oligodontia, hyperdontia) anomalies...
October 21, 2023: BMC Oral Health
https://read.qxmd.com/read/37861389/the-genetic-and-environmental-contributions-to-variation-in-the-permanent-dental-arch-form-a-twin-study
#31
JOURNAL ARTICLE
Ting-Han Lin, Toby Hughes, Maurice J Meade
OBJECTIVE: The objective of this study was to examine the relative contributions of genetic and environmental influences on variation in dental arch form in individuals who have largely completed their craniofacial growth. MATERIAL AND METHODS: The subjects of this study comprised dental casts of 50 monozygotic twins and 24 dizygotic twins from the collection of records of twins housed at the Adelaide Dental School, Australia. The subjects were of Western European descent, with an average age of 20...
October 20, 2023: European Journal of Orthodontics
https://read.qxmd.com/read/37847809/three-dimensional-changes-in-the-cranial-base-associated-with-soft-diet-feeding
#32
JOURNAL ARTICLE
Yuka Murata, Chihiro Tanikawa, Yuki Shiraishi, Toshihiro Inubushi, Kana Kono, Hiroshi Kamioka, Takashi Yamashiro
BACKGROUND: Masticatory activity affects the morphology of the maxillo-mandibular complex, however, its influence on the cranial base remains to be elucidated. The recent integration of quantitative morphometric analysis with 3D imaging enabled a comprehensive and high-resolution morphological characterization of the craniofacial complex. We aimed to investigate the influence of masticatory activity on the morphology of the growing cranial base by three-dimensional (3D) geometric morphometric approach using micro-CT...
October 17, 2023: European Journal of Orthodontics
https://read.qxmd.com/read/37828196/involving-young-people-and-parents-in-decision-making-for-hypodontia
#33
JOURNAL ARTICLE
Sophy Barber, Adam Jones, Veena Abigale Patel, Martin P Ashley
Involving young people and their parents in decisions about their health care is ethically and professionally the right thing to do. Good decision-making relies on informed, value-based deliberation. Providing the right treatment for people with hypodontia is complex, both technically, in terms of the range of options available, and from a communication perspective. Treatment decisions faced by young people with hypodontia can have lifelong implications and the weight of this is felt both by the patient, who may have limited experience of dental treatment and decision-making, and their parents, who act as advocates...
October 2023: British Dental Journal
https://read.qxmd.com/read/37828195/the-genetic-basis-of-hypodontia-in-dental-development
#34
JOURNAL ARTICLE
Alice Duke, Michael Paterson, Martin P Ashley, Lorna MacNab
Dental agenesis is one of the most common developmental anomalies in humans, characterised by the developmental absence of one or more teeth. It can present as an isolated condition (non-syndromic hypodontia) or associated with a syndrome (syndromic hypodontia). This paper aims to review the genetic basis of hypodontia with reference to aetiology, classification and the subsequent clinical features.Significant progress has been made to identify the developmental basis of tooth formation, though there is still a lack of knowledge within the literature of the aetiological basis of inherited tooth loss...
October 2023: British Dental Journal
https://read.qxmd.com/read/37828194/the-role-of-the-general-dental-practitioner-in-the-management-of-the-hypodontia-patient
#35
JOURNAL ARTICLE
Shivani Rana, Courtney Orloff, Deborah I Bomfim, Martin P Ashley, G Steven Bassi
The general dental practitioner (GDP) is usually the first person to suspect that a young patient is affected by hypodontia. The condition occurs rarely in the primary dentition but is relatively common in the permanent dentition. Between the ages of 7 and 12 years, failure of a permanent tooth to erupt as expected will lead the GDP to initiate and then contribute to the ideal management of the patient's condition. This ranges from reassurance and preventive measures to providing aspects of treatment in a long-term management plan, alongside a multidisciplinary specialist team and thereafter, delivery of life-long dental care...
October 2023: British Dental Journal
https://read.qxmd.com/read/37828193/a-service-evaluation-of-the-multidisciplinary-team-approach-to-hypodontia
#36
JOURNAL ARTICLE
Faye Doughty, Sruthi Pillai, Dylan Hamill, Nadine Amin, Martin P Ashley
Introduction Patients with hypodontia can be seen by a multidisciplinary team clinic (MDT) for treatment planning at the University Dental Hospital of Manchester (UDHM). The MDT consists of orthodontics, restorative dentistry and oral surgery colleagues.Aims and methods A retrospective case-note analysis was conducted on 558 hypodontia patients seen on Manchester Hypodontia Clinic (MHC) between 2016-2022 to assess service utilisation and treatment planning outcomes.Results The average age of patients attending the MHC was 16 (range 8-50)...
October 2023: British Dental Journal
https://read.qxmd.com/read/37828183/practical-advice-for-successful-clinical-treatment-with-resin-bonded-bridges
#37
JOURNAL ARTICLE
Stephanie King, Banoo Sood, Martin P Ashley
Resin-bonded bridges are one of the main options for replacing missing teeth for hypodontia patients. This technique offers several advantages for these patients, who are often young, have unrestored abutment teeth, and have had tooth positions optimised by orthodontic treatment. However, the replacement of missing teeth can be challenging due to tooth positions and anomalies of abutment tooth shape and size.These patients are often young adults at the time of restoration, making the minimally invasive nature and predictable long-term success of resin-bonded bridges advantageous over other treatment methods...
October 2023: British Dental Journal
https://read.qxmd.com/read/37828182/the-dental-technician-as-a-member-of-the-hypodontia-multidisciplinary-team-with-practical-considerations-for-anterior-restoration-design
#38
JOURNAL ARTICLE
Stephen Ford, Martin P Ashley
Most patients seeking treatment for hypodontia will require prosthetic replacement of their missing teeth. This will be in the form of dentures, bridges and implant restorations. As these are created by one or more dental technicians who supports the clinical team, a close working relationship between these colleagues is likely to improve the quality of treatment outcome. This interaction will usually occur towards the end of the patient's treatment process, when definitive restorations are prescribed. However, appropriately trained and experienced dental technicians should be involved throughout the patient's treatment process as an integral part of the multidisciplinary team approach to effectively manage these patients...
October 2023: British Dental Journal
https://read.qxmd.com/read/37828181/restorative-dentistry-clinical-decision-making-for-hypodontia-complex-cases
#39
JOURNAL ARTICLE
Adrian Pace-Balzan, Andreas Chatzipantelis, Katharine J Dunn, Garima Charan, Martin P Ashley
Hypodontia is a relatively common condition and patients will be seen by both general dental practitioners and specialist dental colleagues. Although hypodontia can be described as mild, moderate and severe, this does not directly correlate with the complexity of treatment required to provide an acceptable outcome. In addition, the complexity of treatment provided by one colleague in the multidisciplinary team may not be the same as for other colleagues.When treatment planning and delivering dental care for these patients, especially those with severe hypodontia, it is useful to recognise the factors that make their care complex and also to follow principles for multidisciplinary treatment planning...
October 2023: British Dental Journal
https://read.qxmd.com/read/37828180/restorative-dentistry-clinical-decision-making-for-hypodontia-managing-missing-premolar-teeth
#40
JOURNAL ARTICLE
Courtney Orloff, Shivani Rana, G Steven Bassi, Martin P Ashley, Deborah I Bomfim
Hypodontia is a relatively common clinical condition and the second premolar tooth is the most common tooth that fails to develop (excluding third molars). For some patients, no treatment is required, as there is little, if any, consequence of the condition. For other patients, the missing teeth are part of a more complex dental presentation, requiring specialist dental management. This paper describes the clinical decision-making process and explores the options for managing this presentation of hypodontia...
October 2023: British Dental Journal
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