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Allergic rhinitis treatment

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https://www.readbyqxmd.com/read/29678749/benefit-of-bet-v-1-contiguous-overlapping-peptide-immunotherapy-persists-during-first-follow-up-season
#1
Alexander Kettner, Gilles DellaCorte, Fréderic de Blay, Lars Jacobsen, Marek Jutel, Margitta Worm, Vincent Charlon, Kim Simonsen, Christophe Reymond, François Spertini
A short course of 5 injection AIT with Bet v 1 Contiguous Overlapping Peptides was well tolerated and improved allergic rhinitis during the 2nd pollen season after treatment. Long lasting efficacy was associated with a persistent allergen-specific IgG4 response.
April 17, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29678484/chronic-respiratory-rhinitis
#2
R Jankowski, P Gallet, D T Nguyen, C Rumeau
The clinical distinction of chronic respiratory rhinitis appears to confirm the evo-devo theory of the three noses. The authors report two cases of advanced allergic rhinitis, in which chronic inflammation had induced a violaceous colour of the mucosa of the respiratory nose and a whitish polypoid appearance of the free edge of the middle turbinate. Nose and paranasal sinus CT scan revealed, beyond the virtual nasal cavities observed on nasal endoscopy and CT imaging, normal radiolucency or only minor opacities of the ethmoid (i...
April 17, 2018: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/29677549/mir-375-prevents-nasal-mucosa-cells-from-apoptosis-and-ameliorates-allergic-rhinitis-via-inhibiting-jak2-stat3-pathway
#3
Tao Wang, Dong Chen, Peihua Wang, Zhou Xu, Ying Li
This study aims to explore the roles, and related mechanisms of miR-375 in nasal mucosa cells apoptosis and allergic rhinitis. Here, miR-375 was found to be decreased in the epithelia of nasal mucosa of allergic rhinitis mice and TNF-α-stimulated nasal mucosa cells, while JAK2 expression exhibited an opposite effect. Mechanistically, miR-375/JAK2 regulatory axis was identified in nasal mucosa cells via luciferase reporter, qRT-PCR, western blot and RNA immune co-precipitation (RIP) assays. Pre- or post-injection of miR-375 agomir following ovalbumin (OVA) treatment attenuated OVA-induced allergic rhinitis, characterized as the downregulation of IL-6 and TNF-α secretion, and upregulation of IL-10 secretion, these effects were attenuated by infection with JAK2 adenovirus through nasal cavity inhalation...
April 17, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29675865/allergen-immunotherapy-in-people-dogs-cats-and-horses-differences-similarities-and-research-needs
#4
R S Mueller, E Jensen-Jarolim, F Roth-Walter, E Marti, J Janda, A A Seida, D DeBoer
In human patients with seasonal allergic rhinoconjunctivitis sensitized to grass pollen, the first successful allergen immunotherapy (AIT) was reported in 1911. Today, immunotherapy is an accepted treatment for allergic asthma, allergic rhinitis and hypersensitivities to insect venom. AIT is also used for atopic dermatitis and recently for food allergy. Subcutaneous, epicutaneous, intralymphatic, oral and sublingual protocols of AIT exist. In animals, most data are available in dogs where subcutaneous AIT is an accepted treatment for atopic dermatitis...
April 19, 2018: Allergy
https://www.readbyqxmd.com/read/29675754/influence-of-mp-29-02-on-ciliary-beat-frequency-in-human-epithelial-cells-in-vitro
#5
D Häussler, J U Sommer, A Nastev, C Aderhold, A Wenzel, B Kramer, B A Stuck, R Birk
PURPOSE: MP 29-02, which contains fluticasone propionate and azelastine hydrochloride, is used as a topical nasal application for the treatment of seasonal and perennial allergic rhinitis. Although a multitude of data is available on the clinical symptom reduction and treatment safety of MP 29-02, the effect of MP 29-02 on ciliary beat frequency (CBF) has not been evaluated thus far. METHODS: MP 29-02-containing solution was applied at concentrations of 2.5, 5, 10, and 20% to 14 healthy subjects, and nasal ciliated epithelial cells were then visualized using a phase-contrast microscope...
April 19, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29673431/the-aeromedical-management-of-allergic-rhinitis
#6
Nicole Powell-Dunford, Charles Reese, Alaistair Bushby, Berit H Munkeby, Sébastien Coste, Višnja Livajić Pezer, Lars Rosenkvist
INTRODUCTION: Allergic rhinitis is a prevalent condition warranting special aeromedical consideration due to its potential for acute and painful manifestations involving the middle ear or paranasal sinuses during rapid barometric pressure changes. Although second generation antihistamines and intranasal steroids are safe and effective treatments for this common condition, aeromedical management varies. METHODS: An aeromedical policy review of 14 public access civil and military data repositories was undertaken...
May 1, 2018: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29666296/phase-ii-study-to-evaluate-the-efficacy-and-safety-of-rilotumumab-and-bevacizumab-in-subjects-with-recurrent-malignant-glioma
#7
Mary Lou Affronti, Jennifer Gamboa Jackman, Frances McSherry, James E Herndon, Elwood C Massey, Eric Lipp, Annick Desjardins, Henry S Friedman, Gordana Vlahovic, James Vredenburgh, Katherine B Peters
LESSONS LEARNED: Due to evolving imaging criteria in brain tumors and variation in magnetic resonance imaging evaluation, it is not ideal to use response rate as a primary objective. Future studies involving antiangiogenic agents should use overall survival.Disease-expected toxicities should be considered when defining the clinical significance of an adverse event. For example, vascular thromboembolic events are common in brain tumor patients and should not be attributed to the study drug in the safety analysis...
April 17, 2018: Oncologist
https://www.readbyqxmd.com/read/29662303/the-effectiveness-of-long-term-course-of-sterimar-mn-nasal-spray-for-treatment-of-the-recurrence-rates-of-acute-allergic-rhinitis-in-patients-with-chronic-allergic-rhinitis
#8
Michele Grasso, Marco de Vincentiis, Griselda Agolli, Francesco Cilurzo, Raffaele Grasso
Background: The "cost of illness" of the acute allergic rhinitis (AR) episodes in patients with chronic AR is very high in terms of therapy and quality of life. AR represents a worldwide health problem; despite the fact that many standardized treatments have been proposed and used, the recurrence rate of acute rhinitis episodes in springtime is always higher. Materials and methods: Sixty consecutive patients (13 F and 17 M in group A, 15 F and 15 M in group B; p =0...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29661187/incidence-and-risk-factors-for-recurrent-henoch-sch%C3%A3-nlein-purpura-in-children-from-a-16-year-nationwide-database
#9
Wei-Te Lei, Po-Li Tsai, Szu-Hung Chu, Yu-Hsuan Kao, Chien-Yu Lin, Li-Ching Fang, Shyh-Dar Shyur, Yu-Wen Lin, Shu-I Wu
BACKGROUND: The recurrence rate of Henoch-Schönlein purpura (HSP) is 2.7%-30%, with varied average intervals between the first and second episodes. Few studies have explored the incidence and risk factors for recurrent HSP. METHODS: We used a 16-year nationwide database to analyze the incidence of recurrent HSP. Patients with HSP were identified, and risk factors for recurrent HSP were explored. Kaplan-Meier and Cox regression model analyses were performed, and covariates were adjusted in the multivariate model...
April 16, 2018: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/29656145/sq-house-dust-mite-sublingual-immunotherapy-tablet-subgroup-efficacy-and-local-application-site-reaction-duration
#10
David I Bernstein, Joerg Kleine-Tebbe, Harold S Nelson, Jose A Bardelas, Gordon L Sussman, Susan Lu, Dorte Rehm, Bodil Svanholm Fogh, Hendrik Nolte
BACKGROUND: Allergic rhinitis with or without conjunctivitis (AR/C) is common, necessitating evaluation of SQ house dust mite (HDM) sublingual immunotherapy (SLIT)-tablet efficacy in various subgroups. OBJECTIVE: To evaluate 12 SQ-HDM efficacy and safety across subgroups, and the onset, duration, and recurrence of local application site reactions. METHODS: Subgroup (age, gender, race, asthma status, and allergen sensitization) efficacy was assessed using pooled data from two previously described trials of daily 12 SQ-HDM vs placebo for AR/C (N=2138)...
April 12, 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29649887/clinical-effect-of-endoscopic-vidian-neurectomy-on-bronchial-asthma-outcomes-in-patients-with-coexisting-refractory-allergic-rhinitis-and-asthma
#11
Jingang Ai, Zuozhong Xie, Xiang Qing, Wei Li, Honghui Liu, Tiansheng Wang, Guolin Tan
Background The prevalence of both allergic rhinitis and bronchial asthma is high throughout the world; their mutual influence on each other has been documented in many studies. However, studies regarding surgical intervention are limited. Objective To evaluate the clinical significance of endoscopic vidian neurectomy on bronchial asthma outcomes in patients with coexisting refractory allergic rhinitis and asthma. Methods A total of 109 patients with moderate to severe persistent intractable allergic rhinitis and mild/moderate asthma were allocated to the bilateral endoscopic vidian neurectomy group (group 1) or conservative medication group (group 2) according to the patients' self-selection...
January 1, 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29649882/local-atopy-in-childhood-adenotonsillar-hypertrophy
#12
Kyu-Sup Cho, Seong Heon Kim, Sung-Lyong Hong, Jaeyoung Lee, Sue Jean Mun, Young Eun Roh, Young Mi Kim, Hye-Young Kim
Background Although the cause of adenotonsillar hypertrophy remains unknown, some studies have shown that allergy may be a risk factor. Purpose This study determined the levels of allergen-specific immunoglobulin E (sIgE) in the adenotonsillar tissues of children with adenotonsillar hypertrophy and evaluated the clinical significance of local atopy in adenotonsillar tissues. Methods We measured 21 types of specific immunoglobulin E in the serum and adenotonsillar tissues of 102 children with adenotonsillar hypertrophy and compared the sensitization patterns of the serum and local tissues...
January 1, 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29644886/effects-of-a-thermosensitive-in-situ-gel-containing-mometasone-furoate-on-a-rat-allergic-rhinitis-model
#13
Ebru Altuntaş, Gülgün Yener, Remzi Doğan, Fadlullah Aksoy, Mehmet Şerif Aydın, Ersin Karataş
Background Mometasone furoate, one of the second generation intranasal corticosteroids, is currently used in suspension form due to its poor solubility. However, this is not favorable for nasal application because of the rapid elimination of the instilled drug from the nasal cavity by mucociliary clearance and delayed onset of action due to the slow dissolution of drug in suspension. Objective The aim of this study was to determine the antiallergic effects of mucoadhesive thermosensitive in situ gel containing mometasone furoate that we developed previously to prolong the contact between the drug and nasal mucosa and to prevent drainage of the formulation in an ovalbumin-induced rat model of allergic rhinitis...
January 1, 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29630100/effect-of-ifn-%C3%AE-2-on-combined-allergic-rhinitis-with-nasal-polyps
#14
Y-T Wang, H Wang, F-L Wang, X-M Qian, S-F Zhuang, M-X Yang, C-X Liu
OBJECTIVE: This study sought to investigate the expression of interferon-λ2 (IFN-λ2) in patients with combined allergic rhinitis and nasal polyps (AR+NP), analyze the correlation between IFN-λ2 and tryptase, interleukin 10 (IL-10), and interleukin 12 (IL-12), and identify its peripheral blood cell origins. PATIENTS AND METHODS: ELISA kits were used to investigate plasma levels of IFN-λ2, tryptase, IL-10, and IL-12 in AR+NP patients and healthy controls (HC)...
March 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29626629/the-burden-of-allergic-rhinitis-and-allergic-rhinoconjunctivitis-on-adolescents-a-literature-review
#15
REVIEW
Michael S Blaiss, Eva Hammerby, Susan Robinson, Tessa Kennedy-Martin, Sarah Buchs
OBJECTIVE: To evaluate the literature regarding the burden of allergic rhinitis (AR) and allergic rhinoconjunctivitis (ARC) in adolescents (10-19 years). DATA SOURCES: Searches were performed in MEDLINE, Embase, Health Technology Assessment Database, and National Health Service Economic Evaluation Database for studies evaluating concepts of symptoms, quality of life (QOL), daily activities, sleep, examination performance, school absenteeism and presenteeism, and treatment burden in adolescents with AR or ARC...
April 4, 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29624710/nasal-hyperreactivity-in-rhinitis-a-diagnostic-and-therapeutic-challenge
#16
REVIEW
Laura Van Gerven, Brecht Steelant, Peter W Hellings
Although nasal hyperreactivity (NHR) is a common feature in patients suffering from allergic and non-allergic rhinitis, it is widely neglected during history taking, underdiagnosed in the majority of patients with rhinitis and rhinosinusitis, not considered as an outcome parameter in clinical trials on novel treatments for rhinitis and rhinosinusitis, and no target for routine treatment. In contrast to the simple nature of diagnosing NHR by a history of nasal symptoms induced by non-specific exogenous and/or endogenous triggers, quantification is hardly performed in routine clinic given the lack of a simple tool for its diagnosis...
April 6, 2018: Allergy
https://www.readbyqxmd.com/read/29620295/-place-of-immunotherapy-in-allergic-asthma
#17
Ophélie Marchal, Daniele Allali
Desensitization for pneumallergens is used in daily practice for the treatment of allergic rhinitis and allergic asthma. However, specific immunotherapy has long been debated in the medical literature as a treatment for allergic asthma until the latest international recommendations for the management of asthma (GINA) reveal specific immunotherapy as a treatment in sensitized patients, poorly controlled by inhaled corticosteroids (FEV 1 > 70%). In this article you will find a current overview of the medical literature on the usefulness of specific desensitization to reduce asthma symptoms and symptomatic treatments, prevent the onset of asthma in patients with allergic rhinitis as well as prevent new sensitizations...
April 4, 2018: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29619134/type-b-adverse-drug-reactions-reported-by-an-immunoallergology-department
#18
Maria J Costa, Maria T Herdeiro, Jorge J Polónia, Inês Ribeiro-Vaz, Cármen Botelho, Eunice Castro, Josefina Cernadas
Objective: Characterization of the adverse drug reactions (ADR) reported by the immunoallergology department (IAD), Centro Hospitalar de São João (Porto), to the Northern Pharmacovigilance Centre (NPC). Methods: An observational, descriptive and retrospective study was conducted, based in a spontaneous report system. Participants were all the patients from the IAD, with suspected ADR, reported to NPC by specialists after the study was completed. Results: Studied population had a median age of 41 years, with the predominance of the female gender (73...
January 2018: Pharmacy Practice
https://www.readbyqxmd.com/read/29615844/bepotastine-besilate-ophthalmic-solution-1-5-for-alleviating-nasal-symptoms-in-patients-with-allergic-conjunctivitis
#19
Megan E Cavet, Paul J Gomes, Warner W Carr, Jon I Williams
Background: Bepotastine besilate ophthalmic solution (BBOS) 1.5% is a topical antihistamine for the treatment of ocular itching associated with allergic conjunctivitis (AC). Allergic rhinitis and AC are common comorbid conditions. We explored the efficacy of BBOS 1.5% in alleviating nasal symptoms in an integrated analysis of two Phase III conjunctival allergen challenge (CAC) studies and a Phase IV environmental allergen study. Methods: In the Phase III trials, a CAC was performed 15 minutes, 8 hours, and 16 hours following ocular instillation of BBOS 1...
2018: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/29611384/allergen-microarrays-for-in-vitro-diagnostics-of-allergies-comparison-with-immunocap-and-advansure
#20
Hyunjin Jeon, Joo Hyun Jung, Yoonji Kim, Youngeun Kwon, Seon Tae Kim
BACKGROUND: In vitro detection of the allergen-specific IgE antibody (sIgE) is a useful tool for the diagnosis and treatment of allergies. Although multiple simultaneous allergen tests offer simple and low-cost screening methods, these platforms also have limitations with respect to multiplexibility and analytical performance. As an alternative assay platform, we developed and validated a microarray using allergen extracts that we termed "GOLD" chip. METHODS: Serum samples of 150 allergic rhinitis patients were used in the study, and the diagnostic performance of the microarray was compared with that of AdvanSure (LG Life Sciences, Daejun, Korea) and ImmunoCAP (Phadia, Uppsala, Sweden)...
July 2018: Annals of Laboratory Medicine
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