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Allergic rhinitis treatment

Maureen Egan, Dan Atkins
PURPOSE OF REVIEW: Observations suggesting that aeroallergens trigger eosinophilic esophagitis (EoE) in a subset of patients raise questions about the implications this finding has on the evaluation and management of patients with EoE, including a potential role for allergen immunotherapy. RECENT FINDINGS: The majority of studies evaluating the potential role of aeroallergens as provocateurs of EoE have addressed this issue by assessing the seasonal variation in EoE diagnosis and/or symptom onset or worsening, with mixed results...
June 16, 2018: Current Allergy and Asthma Reports
Shital Patil, Rajesh Patil
Allergic bronchopulmonary aspergillosis (ABPA) is underdiagnosed and underevaluated routinely because of clinical and radiological overlap with tuberculosis (TB), especially in tropical setting with high TB burden countries like India. ABPA is the best-recognized manifestation of Aspergillus-associated hypersensitivity to Aspergillus antigens in patients with long-standing atopic asthma. ABPA with varied clinical presentation has been reported to occur in 20% of asthmatic patients admitted to hospitals and in 5% of all rhinitis cases...
April 2018: International Journal of Mycobacteriology
Paloma Campo, Ibon Eguiluz-Gracia, Gador Bogas, María Salas, Carmen Plaza Serón, Natalia Pérez, C Mayorga, M J Torres, Mohammed Shamji, Carmen Rondon
A significant proportion of rhinitis patients without systemic IgE-sensitization tested by skin prick test and serum allergen-specific IgE (sIgE) display nasal reactivity upon nasal allergen provocation test (NAPT). This disease phenotype has been termed local allergic rhinitis (LAR). LAR is an underdiagnosed entity affecting children and adults from different parts of the world, with moderate-to-severe symptoms, impairment of quality of life and rapid progression to symptom worsening. LAR is a stable phenotype and not merely an initial state of AR...
June 14, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
Yichen Xiao, Wenna Xu, Wenru Su
Allergic diseases, such as asthma, rhinitis, dermatitis, conjunctivitis, and anaphylaxis, have recently become a global public health concern. According to previous studies, the NLRP3 inflammasome is a multi-protein complex known to be associated with many inflammatory conditions. In response to allergens or allergen/damage-associated molecular signals, NLRP3 changes its conformation to allow the assembly of the NLRP3 inflammasome complex and activates caspase-1, which is an evolutionarily conserved enzyme that proteolytically cleaves other proteins, such as the precursors of the inflammatory cytokines IL-1β and IL-18...
June 13, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
Yongqiang Zhao, X Ma, Y Li, Q Fu
OBJECTIVES: As part of the UN peacekeeping mission in Mali, the People's Republic of China have deployed a level 2 medical treatment facility (CHN L2). The aim of this study was to review the cases managed by the otolaryngology service within this facility. METHODS: The medical records of all patients treated by the otolaryngology service at the CHN L2 from 1 March 2015 to 1 March 2018 were retrospectively assessed. RESULTS: 614/10189 (6%) of all cases seen in the hospital during this period were referred to the otolaryngology service...
June 11, 2018: Journal of the Royal Army Medical Corps
Zengfeng Pan, Yuan Zhou, Xia Luo, Yan Ruan, Lian Zhou, Qing Wang, Ya Jie Yan, Qi Liu, Jinyan Chen
BACKGROUND: The prevalence of allergic rhinitis has risen sharply. Previous work has demonstrated the anti-inflammatory effect of catechin, including in models of allergic disease. However, the molecular mechanisms underlying this therapeutic effect remain unclear. Thymic stromal lymphopoietin(TSLP), as a molecule from epithelial cell, has been identified that plays a significant role in the development of allergic disease, and the production of TSLP is related to activation of the NF-κB signaling pathway...
June 8, 2018: International Immunopharmacology
S R Devarajan, N Zarrin-Khameh, P Alapat
We present a case of a 76 year-old, non-smoking Honduran female who was referred to our clinic for years of persistent dry cough. Cardiac evaluation was unremarkable. She denied symptoms of heartburn, allergic rhinitis, and there was no personal or family history of asthma. Her physical exam demonstrated wheezing over the right mid-posterior chest. Spirometry was within normal limits. CT-imaging of the chest demonstrated right middle lobe bronchus and lingular segmental bronchus narrowing with bibasilar atelectasis and mild interlobular septal thickening with prominent mediastinal adenopathy...
2018: Respiratory Medicine Case Reports
Fei-Hong Liang, Xun-Rui Hou, Li-Hong Li, Xin Liang, Yu-Wei Lu, Hong Yang, Yuan Zhang
OBJECTIVE: To observe the effect of acupoint injection at "Yingxiang"(LI 20) and "Yintang"(GV 29) on nasal allergic reactions and the expression of histamine receptor H 1 and H 4 in nasal mucosa of allergic rhinitis (AR) rats, so as to reveal its mechanism underlying improvement of AR. METHODS: SD rats were randomized into normal, model, non-acupoint injection and acupoint injection groups ( n =8 in each). The AR model was established by intraperitoneal (i...
April 25, 2018: Zhen Ci Yan Jiu, Acupuncture Research
Rongfei Zhu, Jingru Wang, Yuying Wu, Yongshi Yang, Nan Huang, Yaqi Yang, Rui Zhang, Dongxia Ma, Lin Yang, Pascal Demoly
BACKGROUND: Allergic Rhinitis Control Test(ARCT) has been validated in allergic rhinitis(AR) step-up pharmacotherapy management approach. OBJECTIVE: The aim of our study was to evaluate the potential of ARCT in AR step-down pharmacotherapy. METHODS: In an open-labelled randomized controlled study, AR patients controlled with intranasal corticosteroid(INS) plus antihistamine(step 4) were included and randomized into an ARCT or a control group...
June 7, 2018: Journal of Allergy and Clinical Immunology in Practice
Bei Yue, Yi-Jing Ren, Jing-Jing Zhang, Xiao-Ping Luo, Zhi-Lun Yu, Gai-Yan Ren, A-Ning Sun, Chao Deng, Zheng-Tao Wang, Wei Dou
Fargesin is a bioactive lignan from Flos Magnoliae , an herb widely used in the treatment of allergic rhinitis, sinusitis, and headache in Asia. We sought to investigate whether fargesin ameliorates experimental inflammatory bowel disease (IBD) in mice. Oral administration of fargesin significantly attenuated the symptoms of dextran sulfate sodium (DSS)-induced colitis in mice by decreasing the inflammatory infiltration and myeloperoxidase (MPO) activity, reducing tumor necrosis factor (TNF)-α secretion, and inhibiting nitric oxide (NO) production in colitis mice...
June 7, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Jing Qu, Chang Liu, Hai-Hong Lian, Xiang-Dong Wang, Nan Zhi
This study aims to investigate the effectiveness and safety of Qingfeijianpi therapy for persistent allergic rhinitis (AR).A total of 101 patients with persistent AR were included into the study. These patients were randomly divided into 2 groups: treatment group, in which patients were given Qingfeijianpi decoction (1 dose/day for 4 weeks); control group, in which patients were given an oral dose of loratadine (tablet, 10 mg/time, once per day for 4 weeks). A total of 96 patients completed the 16-week course of treatment...
June 2018: Medicine (Baltimore)
Sangeeta Dhami, Arnav Agarwal
PURPOSE OF REVIEW: Cat allergy can manifest as allergic rhinitis, conjunctivitis and/or asthma. With widespread cat ownership and exposure, cat allergy has emerged as a major cause of morbidity. Cat allergen immunotherapy is a potential disease modifying treatment for patients with cat allergy. We examine evidence on the effectiveness, cost-effectiveness and safety of cat allergen immunotherapy and consider the clinical contexts in which it should be prescribed. RECENT FINDINGS: The European Association of Allergy and Clinical Immunology systematic reviews on allergic rhinitis and asthma along with the accompanying guidelines on allergic rhinitis were used as primary sources of evidence...
June 4, 2018: Current Opinion in Allergy and Clinical Immunology
Anthony Ca Yii, Tunn-Ren Tay, Xue Ning Choo, Mariko Sy Koh, Augustine Kh Tee, De-Yun Wang
United airways disease (UAD) is the concept that the upper and lower airways, which are anatomically and immunologically related, form a single organ. According to this concept, upper and lower airway diseases are frequently comorbid because they reflect manifestations of a single underlying disease at different sites of the respiratory tract. Allergic asthma-allergic rhinitis is the archetypal UAD, but emerging data indicate that UAD is a heterogeneous condition and consists of multiple phenotypes (observable clinical characteristics) and endotypes (pathobiologic mechanisms)...
June 5, 2018: Allergy
Amy Huang, Christine Cho, Donald Y M Leung, Kanwaljit Brar
Therapeutic regimens for the treatment and long-term management of AD traditionally had a two-fold objective of decreasing skin inflammation and repairing the defective skin barrier. Essential treatments for AD in children should include topical moisturizers for skin hydration and prevention of flares, topical anti-inflammatory medications (e.g. corticosteroids, calcineurin inhibitors, PDE4 inhibitor), allergen/irritant avoidance, and treatment of skin infections. Treatment regimens should be severity-based, and implemented in a stepwise approach tailored to the individual patient...
September 2017: Current Treatment Options in Allergy
Ching-Wen Huang, I-Hsuan Hwang, Young-Hee Yun, Bo-Hyoung Jang, Fang-Pey Chen, Shinn-Jang Hwang, Seong-Gyu Ko
BACKGROUND: As the number of people seeking to use traditional medicine to treat common diseases is increasing worldwide, the quantity of information that needs to be analyzed is also increasing. Traditional medicine is commonly used in South Korea and Taiwan for treating allergic rhinitis and is covered by the National Health Insurance in both countries. To date, there has been no nationwide comparison of traditional medicine used to treat patients with allergic rhinitis between these two countries...
May 31, 2018: Journal of the Chinese Medical Association: JCMA
Carmen Rondón, Ibon Eguiluz-Gracia, Paloma Campo
PURPOSE OF REVIEW: To examine the recent advances on epidemiological studies, diagnostic approach and clinical management of local allergic rhinitis (LAR) in adults and children. RECENT FINDINGS: Evidence about LAR is growing especially in pediatric and Asian populations. The prevalence of LAR is lower in Asian countries compared with western countries in both children and adults. LAR is considered a chronic condition and an independent rhinitis phenotype that affects up to 26...
May 29, 2018: Current Opinion in Allergy and Clinical Immunology
Keisuke Masuyama, Tomokazu Matsuoka, Atsushi Kamijo
Japanese cedar pollen (JCP) and house dust mite (HDM) are two major allergens that cause allergic rhinitis (AR) in Japan and the prevalence of AR is increasing. Pharmacothearpy is a commonly used treatment, but the level of patient satisfaction is very low. Allergen immunotherapy (AIT) is the only therapeutic modality that provides not only symptom relief but also quality of life improvement that leads to a high rate of satisfaction. In particular, sublingual immunotherapy (SLIT) is a safe and effective treatment for AR...
May 25, 2018: Allergology International: Official Journal of the Japanese Society of Allergology
Suresh Mohan, Jennifer C Fuller, Stephanie Friree Ford, Robin W Lindsay
Importance: Nasal airway obstruction (NAO) is a common complaint in the otolaryngologist's office and can have a negative influence on quality of life (QOL). Existing diagnostic methods have improved, but little consensus exists on optimal tools. Furthermore, although surgical techniques for nasal obstruction continue to be developed, effective outcome measurement is lacking. An update of recent advances in diagnostic and therapeutic management of NAO is warranted. Objective: To review advances in diagnosis and treatment of NAO from the last 5 years...
May 10, 2018: JAMA Facial Plastic Surgery
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No abstract text is available yet for this article.
May 15, 2018: Annals of Internal Medicine
Y J Wu, P Wang, Z X Liu, S Q Qiu
Objective: The aim of this study is to evaluate the efficacy of sublingual immunotherapy (SLIT) with standardized dermatophagoides farinae drops and to examine the change of TGF-β and IL-13 mRNA level after 12 months SLIT in children with allergic rhinitis (AR). Method: Ninety-two children with AR were collected and randomly divided into two groups: SLIT group ( n =62) and control group ( n =30). Before and after SLIT for 6 months and 12 months, total nasal symptoms score (TNSS) and total medication score (TMS) were evaluated...
February 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
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