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Rachid Badaoui, Youssef Alami Chentoufi, Abdelhakim Hchikat, Lionel Rebibo, Ivan Popov, Abdennaceur Dhahri, Ghada Antoun, Jean-Marc Regimbeau, Emmanuel Lorne, Hervé Dupont
STUDY OBJECTIVE: The development of outpatient surgery was one of the major goals of public health policy in 2010. The purpose of this observational prospective study was to evaluate the feasibility of laparoscopic sleeve gastrectomy (SG) in an ambulatory setting. DESIGN: Study design was a prospective prospective observational, nonrandomized study, registered ( identifier: NCT01513005), with institutional review board approval and written informed consent...
November 2016: Journal of Clinical Anesthesia
Magda Nowicki, Steven Tran, Arrujyan Muraleetharan, Stefan Markovic, Robert Gerlai
Motor function and anxiety-like responses are easily quantifiable in zebrafish, a novel model organism for behavioral pharmacology. Activation of serotonin receptors through the use of selective agonists has been shown to alter anxiety-like behaviors in zebrafish. However, few studies have examined the effect of blockade of specific serotonin receptors. In the current study, we examine the effect of 4 serotonin receptor antagonists selective for 5-HT1A, 5-HT1B/D, 5-HT2, and 5-HT3 receptors on zebrafish motor and anxiety-like responses...
November 2014: Pharmacology, Biochemistry, and Behavior
Georgios I Tagarakis, Christos Voucharas, Fani Tsolaki, Marios E Daskalopoulos, Vassilios Papaliagkas, Charalampos Parisis, Eleni Gogaki, Iotalias Tsagalas, Iotalias Sataitidis, Magda Tsolaki, Nikolaos B Tsilimingas
BACKGROUND: To investigate the controlling efficacy of ondasetron and haloperidol in regard to the postcardiotomy delirium. METHODS: We included in this prospective, randomized, double-blinded study 80 patients who developed delirium after heart surgery with the application of heart lung-machine. The patients were divided into two, equally-sized groups, which on detection of delirium received ondasetron 8 mg iv or haloperidol 5 mg iv respectively. The statistical analysis compared the baseline and demographic characteristics of the two groups (age, gender, comorbidities, years of education, type of surgery etc...
March 21, 2012: Journal of Cardiothoracic Surgery
Li Nan Zhang, Su Wen Su, Fang Guo, Hui Cai Guo, Xiao Lu Shi, Wen Ya Li, Xu Liu, Yong Li Wang
BACKGROUND: The aim of this study was to investigate whether serotonin (5-hydroxytryptamine, 5-HT) can modulate Na+/K+ pump in rat hippocampal CA1 pyramidal neurons. RESULTS: 5-HT (0.1, 1 mM) showed Na+/K+ pump current (Ip) densities of 0.40 ± 0.04, 0.34 ± 0.03 pA/pF contrast to 0.63 ± 0.04 pA/pF of the control of 0.5 mM strophanthidin (Str), demonstrating 5-HT-induced inhibition of Ip in a dose-dependent manner in hippocampal CA1 pyramidal neurons. The effect was partly attenuated by ondasetron, a 5-HT3 receptor (5-HT3R) antagonist, not by WAY100635, a 5-HT1AR antagonist, while 1-(3-Chlorophenyl) biguanide hydrochloride (m-CPBG), a 5-HT3R specific agonist, mimicked the effect of 5-HT on Ip...
2012: BMC Neuroscience
María Paz Serrano Fernández, María Jesús Gutiérrez Vilella, Angeles Pérez Martín-Palanco, Francisco Vanaclocha Sebastián, Luis Cabezón Gutiérrez
OBJECTIVE: to evaluate the role of local cold applied to the tips on the prevention of palmar-plantar erythrodysaesthesia (PPE) caused by pegylated liposomal doxorubicin (PLD). MATERIALS AND METHODS: from may 2006 to june 2009, 8 patients with cutaneous T-cell lymphoma mycosis fungoides type were treated with PLD. The median age was 56 years and was administered a total of 63 cycle, with an average of 7.87 cycle per person, with a dose of PLD 20 mg/m2 every 2 weeks...
September 2011: Revista de Enfermería
W Pielichowski, J Barzal, K Gawronski, B Mlot, S Oborska, A Wasko-Grabowska, P Rzepecki
OBJECTIVE: We performed a clinical study of a triple-drug combination to evaluate its efficacy to prevent both acute and delayed emesis after high-dose chemotherapy with BEAM (BCNU [carmustine]+etoposide+ARA-C [cytarabine]+melphalan) before hematopoietic stem cell transplantation (HSCT) by comparison with a historical control group of patients treated with dexamethasone (dex) and ondansetron or palonosetron. METHODS: We evaluated 96 patients non-Hodgkin's lymphomas (n=54), and Hodgkin's disease (n=42)...
October 2011: Transplantation Proceedings
Helene Sudour, Claudine Schmitt, Audrey Contet, Pascal Chastagner, François Feillet
No abstract text is available yet for this article.
March 2011: American Journal of Hematology
Xiaorong Dong, Jing Huang, Rubo Cao, Li Liu
Lung cancer is the leading cause of cancer-related death for both men and women worldwide, and lung cancer also has the highest morbidity and mortality rate among all cancers in China. Chemotherapy (CT) is the most effective and most widely used treatment for lung cancer. Nausea and vomiting are still among the most unpleasant side effects of chemotherapy, especially during highly emetogenic chemotherapy. The standard therapy for preventing chemotherapy-induced nausea and vomiting (CINV) is 5-hydroxytryptamine 3 (5-HT3) receptor antagonists...
December 2011: Medical Oncology
D Ionescu, C Mitre, L Leuke, C Bertianu, G Paskarenko, C Puia, M Bertianu
This randomized double-blind study was undertaken to evaluate the efficacy of ondasetron and dexamathesone in reducing the incidence of postoperative nausea and vomiting after laparoscopic cholecystectomy. The study covered 60 patients (ASA I/II) who had undergone laparoscopic cholecystectomy under general anesthesia. The patients were divided into two groups: 1) 30 patients who received dexamethasone, 4 mg i.v.; and 2) 30 patients who took ondansetron, 4 mg i.v., prior to general anesthesia. Postoperatively, nausea, vomiting, and severe pain (VAS) were observed every 6 hours within the first 24 hours...
March 2007: Anesteziologiia i Reanimatologiia
J Parga, J Rodriguez-Pallares, A Muñoz, M J Guerra, J L Labandeira-Garcia
Inductive signals mediating the differentiation of neural precursors into serotonergic (5-HT) or dopaminergic neurons have not been clarified. We have recently shown that in cell aggregates obtained from rat mesencephalic precursors, reduction of serotonin levels induces a marked increase in generation of dopaminergic neurons. In the present study we treated rat neurospheres with antagonists of the main subtypes of 5-HT receptors, 5-HT transport inhibitors, or 5-HT receptor agonists, and studied the effects on generation of dopaminergic neurons...
January 2007: Developmental Neurobiology
W Abenhardt, D Bosse, L Böning, P Bojko, H Hitz, S Völkl, M Fromm, J Mittermüller, N Göldel, H-D Schick, H Dietzfelbinger, A Hinke
BACKGROUND AND OBJECTIVE: 5-hydroxytryptamine 3 (5-HT3) receptor antagonists have proved to be highly efficacious in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). However, several questions remain concerning the relative efficacy of various approved anti-emetics, especially with respect to dosage, duration and timing of administration, as well as differences in toxicity profiles. Thus it seemed appropriate to assess the current therapeutic results in routine daily practice, when applying antiemetic therapy according to established guidelines...
December 1, 2006: Deutsche Medizinische Wochenschrift
Joseph Ahn, Eli D Ehrenpreis
Irritable bowel syndrome (IBS) is a functional GI disorder that is associated with abdominal discomfort and altered bowel habits. It accounts for up to 28% of patients presenting to a gastroenterology practice and poses a significant personal, societal and economic burden internationally. The Manning, Rome I and Rome II criteria were developed to identify appropriate IBS patients for entry into IBS studies in a consistent manner. Refinements in the understanding of the physiology of the enteric nervous system (ENS), which controls motility, secretion and sensation, provided the basis for our comprehension of the pathophysiology of IBS...
January 2002: Expert Opinion on Pharmacotherapy
J Aleksandrović, A Dagović, B Jeremić
We summarized the current knowledge about chemotherapy and radiotherapy-induced nausea and vomiting. Nausea and vomiting are among the most frequent side effects in the treatment of malignancies, and they are very unpleasant for the patient. We reviewed basic aetiological and physiological mechanisms (except that of delayed emesis, which is not enough explored), particularly the role of serotonin in acute chemotherapy and radiotherapy-induced nausea and vomiting. An oncologist cannot make many changes in the treatment of malignancies and patient-related prognostic factors, but he (she) can make changes in the treatment of nausea and vomiting in order to improve the quality of life of patients with malignancies...
July 1998: Srpski Arhiv za Celokupno Lekarstvo
G Barrenetxea, J Schneider, M M Centeno, H Romero, M de la Rica, F J Rodríguez-Escudero
The objective of the present study was to examine the problem of the control of nausea and vomiting induced by non-cisplatin containing cyclophosphamide-based chemotherapy regimens in breast cancer patients. This was randomized, double-blind, parallel-group and placebo-controlled study comparing the efficacy of three antiemetic therapeutic regimens (ondansetron for 3 days, ondasetron plus metoclopramide, and ondansetron given in a single dose) in breast cancer patients receiving cyclophosphamide-based chemotherapy regimens on an outpatient basis...
1996: Cancer Chemotherapy and Pharmacology
S C Hui, E L Sevilla, C W Ogle
1. The effects of the 5-HT3 receptor antagonists, ondansetron and tropisetron, on morphine consumption were studied in naive and morphine-dependent rats. 2. The administration of ondansetron (1 microgram kg-1, i.p. twice daily) 7 days prior to, and during a 21-day period of, morphine availability (increasing concentration from 0.1 to 0.4 mg ml-1) in 5% sucrose solution reduced opiate intake from the 9th day of morphine treatment. 3. The administration of ondansetron (0.1 microgram kg-1, i.p. twice daily) or tropisetron (0...
December 1993: British Journal of Pharmacology
E Campora, S Giudici, L Merlini, A Rubagotti, R Rosso
The antiemetic efficacy of ondansetron and dexamethasone (Ondex) was randomly compared to that of high-dose metoclopramide, dexamethasone, and orphenadrine (Control) in the prevention of emesis induced by cyclophosphamide-doxorubicin chemotherapy in 64 chemotherapy-naive breast cancer patients. For the control of acute emesis (day 1), patients were randomized to receive either ondasetron 8 mg p.o. 1 hour prior to chemotherapy (CT) and repeated after 6 and 12 hours plus dexamethasone 20 mg i.v. 40 minutes prior to CT (Ondex) or dexamethasone 20 mg i...
December 1994: American Journal of Clinical Oncology
P Paudice, M Raiteri
1. The effects of 5-hydroxytryptamine (5-HT) on the release of cholexystokinin-like immunoreactivity (CCK-LI) were examined in synaptosomes prepared from rat cerebral cortex and nucleus accumbens and depolarized by superfusion with 15 mM KCl. 2. In both areas 5-HT, tested between 0.1 and 100 nM, increased the calcium-dependent, depolarization-evoked CCK-LI release in a concentration-related manner. The concentration-response curves did not differ significantly between the two brain areas (EC50: 0.4 +/- 0.045 nM and 0...
July 1991: British Journal of Pharmacology
M Binder, A Winkler, R Dorffner, E Glebowski, K Wolff, H Pehamberger
19 patients with advanced malignant melanoma were treated with fotemustine and dacarbazine. Data recorded and available for evaluation in all patients included clinical and histopathological parameters of the primary melanoma, blood chemistry, blood cell count, chest X-ray, ultrasound and bone scan for initial staging of the site of metastases and follow-up during treatment. Dosage was fotemustine 100 mg/m2 and dacarbazine 200 mg/m2 intravenously twice monthly on days 1 and 8, repeated for a maximum of six courses...
1992: European Journal of Cancer
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