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rhinoconjunctivitys in pediatrics

C Mastrorilli, S Tripodi, C Caffarelli, S Perna, A Di Rienzo-Businco, I Sfika, R Asero, A Dondi, A Bianchi, C Povesi Dascola, G Ricci, F Cipriani, N Maiello, M Miraglia Del Giudice, T Frediani, S Frediani, F Macrì, C Pistoletti, I Dello Iacono, M F Patria, E Varin, D Peroni, P Comberiati, L Chini, V Moschese, S Lucarelli, R Bernardini, G Pingitore, U Pelosi, R Olcese, M Moretti, A Cirisano, D Faggian, A Travaglini, M Plebani, M C Verga, M Calvani, P Giordani, P M Matricardi
BACKGROUND: Pollen-food syndrome (PFS) is heterogeneous with regard to triggers, severity, natural history, comorbidities, and response to treatment. Our study aimed to classify different endotypes of PFS based on IgE sensitization to panallergens. METHODS: We examined 1271 Italian children (age 4-18 years) with seasonal allergic rhinoconjunctivitis (SAR). Foods triggering PFS were acquired by questionnaire. Skin prick tests were performed with commercial pollen extracts...
August 2016: Allergy
Ahmed Ragab, Taghreed Farahat, Ghada Al-Hendawy, Rehab Samaka, Seham Ragab, Amira El-Ghobashy
OBJECTIVES: Acute rhinosinusitis (ARS) is a common pediatric problem. Our aim was to determine the efficacy of normal nasal saline irrigation (NSI) with or without amoxicillin in treatment of acute rhinosinusitis (ARS) in children. METHODS: It is a prospective randomized, blind placebo-controlled trial. Children with uncomplicated ARS were recruited. One group received (amoxacillin 100mg/kg/day) and 0.9% NSI. The second group received placebo and 0.9% NSI. The primary outcome was the effect of treatment on clinical response...
December 2015: International Journal of Pediatric Otorhinolaryngology
Klaus Rose, Matthias Volkmar Kopp
Allergen-specific immunotherapy (SIT) is the only disease-modifying treatment for children, adolescents, and adults with allergic diseases. The EU has a combined system of national and EU-wide marketing authorization for all medicines. Germany introduced a new therapy allergen ordinance in 2008. Allergen products manufacturers had to apply for marketing authorization application for the major allergen groups (grass group, birch group, mites group, bee/wasp venom). Due to the EU pediatric regulation, in force since 2007, manufacturers had also to submit a pediatric investigation plan (PIP) for each allergen product...
December 2015: Pediatric Allergy and Immunology
Oliver Pfaar, Claus Bachert, Albrecht Bufe, Roland Buhl, Christof Ebner, Peter Eng, Frank Friedrichs, Thomas Fuchs, Eckard Hamelmann, Doris Hartwig-Bade, Thomas Hering, Isidor Huttegger, Kirsten Jung, Ludger Klimek, Matthias Volkmar Kopp, Hans Merk, Uta Rabe, Joachim Saloga, Peter Schmid-Grendelmeier, Antje Schuster, Nicolaus Schwerk, Helmut Sitter, Ulrich Umpfenbach, Bettina Wedi, Stefan Wöhrl, Margitta Worm, Jörg Kleine-Tebbe, Susanne Kaul, Anja Schwalfenberg
The present guideline (S2k) on allergen-specific immunotherapy (AIT) was established by the German, Austrian and Swiss professional associations for allergy in consensus with the scientific specialist societies and professional associations in the fields of otolaryngology, dermatology and venereology, pediatric and adolescent medicine, pneumology as well as a German patient organization (German Allergy and Asthma Association; Deutscher Allergie- und Asthmabund, DAAB) according to the criteria of the Association of the Scientific Medical Societies in Germany (Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften, AWMF)...
2014: Allergo Journal International
Bjørg Evjenth, Tonje E Hansen, Jan Holt
OBJECTIVE: Fractional exhaled nitric oxide (FENO) and exercise testing are widely used for the evaluation of pediatric asthma. The evidence relating to the effects of strenuous exercise on FENO in children is conflicting. Little information is available on the association between exercise and FENO in relation to allergic rhinoconjunctivitis (AR). We aimed to investigate the effects of AR on children's FENO in response to a standardized treadmill exercise test. METHODS: A total of 124 children with current asthma and 124 non-asthmatic children aged 8-16 years were studied...
October 2015: Journal of Asthma: Official Journal of the Association for the Care of Asthma
Elie Serrano, Hans Ulrich Wahn, Alain Didier, Claus Bachert
BACKGROUND: 300IR 5-grass pollen sublingual immunotherapy tablets have been approved for the treatment of allergic rhinitis (AR) with or without conjunctivitis in adults and children >5 years with grass pollen allergy. This study was designed to review data on nasal symptoms with 300IR 5-grass pollen sublingual tablets in adults and children. METHODS: We reviewed data from four double-blind, placebo-controlled, randomized clinical trials. Two groups of patients who received a daily dose of either placebo or 300IR 5-grass pollen sublingual tablets starting 4 months before the expected start of the pollen season and continuing through the season were compared (analysis of covariance) for scores of sneezing, rhinorrhea, nasal pruritus, nasal congestion, total nasal symptom score (TNSS), and adult Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) scores...
November 2014: American Journal of Rhinology & Allergy
Nicole Pleskovic, Ashton Bartholow, David P Skoner
PURPOSE OF REVIEW: Sublingual immunotherapy (SLIT) is indicated for the use in pediatric patients suffering from allergic rhinitis or allergic rhinoconjunctivitis caused by environmental allergens, such as ragweed pollen, grass pollen, and dust mite. This review focuses on recent and relevant studies associated with the use of SLIT for these allergens in children by examining efficacy, safety, and immunological data in comparison to subcutaneous immunotherapy, therapeutic treatments, and placebo...
December 2014: Current Opinion in Allergy and Clinical Immunology
Helena Munivrana Skvorc, Davor Plavec, Stefanija Munivrana, Marko Skvorc, Boro Nogalo, Mirjana Turkalj
OBJECTIVE: To estimate the prevalence of symptoms of asthma, allergic rhinitis/rhinoconjuctivitis and atopic eczema symptoms in the Medimurje County in Northwest Croatia. SUBJECTS AND METHODS: The study was undertaken between January and April 2005 among school children in 27 randomly selected elementary schools. Data were collected using standardized ISAAC written questionnaire Phase I. RESULTS: A total of 3106 children participated in the study (7-9 yrs) with response rate 96...
March 2014: Lijec̆nic̆ki Vjesnik
Sarah Ronaldson, Matthew Taylor, Peter G Bech, Ruth Shenton, Albrecht Bufe
BACKGROUND: Grass pollen-induced rhinoconjunctivitis is a common allergic respiratory disorder affecting over 20% of the UK population in terms of quality of life and sleep, work, and school patterns. The SQ-standardized grass allergy immunotherapy tablet (AIT) has been demonstrated as a disease-modifying treatment which gives a sustained effect even after completion of a treatment course. The objective of this study was to provide an economic assessment of whether treatment with the SQ-standardized grass AIT, Grazax(®) (Phleum pratense) in combination with symptomatic medications is preferable to the standard of care using symptomatic medications only...
2014: ClinicoEconomics and Outcomes Research: CEOR
Désirée Larenas-Linnemann, Oliver Pfaar
PURPOSE OF REVIEW: Rhinoconjunctivitis, and especially allergic rhinoconjunctivitis (ARC) are increasing in prevalence, progressively affecting the well being of more and more adults and children. Clinical trials using allergen immunotherapy (AIT), the sole causal treatment of allergies, are being conducted, but discussions on optimal patient-related outcomes (PROs) are still ongoing. RECENT FINDINGS: Almost all publications discussing PROs relate to adults. The authors comment on the importance of broader PROs when assessing the results of AIT trials, as focusing on only nasal symptom improvement and medication reduction does not capture the full benefit of AIT...
June 2014: Current Opinion in Allergy and Clinical Immunology
Jennifer Maloney, David I Bernstein, Harold Nelson, Peter Creticos, Jacques Hébert, Michael Noonan, David Skoner, Yijie Zhou, Amarjot Kaur, Hendrik Nolte
BACKGROUND: In North America, few studies have evaluated sublingual immunotherapy for allergic rhinitis with or without conjunctivitis (AR/C); pediatric data are sparse. The authors report findings from the largest published immunotherapy trial yet conducted in adults and children. OBJECTIVE: To evaluate grass sublingual immunotherapy tablet (MK-7243) treatment in subjects with AR/C. METHODS: North American subjects (5-65 years old) with grass allergy were randomized 1:1 to once-daily MK-7243 (2,800 BAU Phleum pratense) or placebo...
February 2014: Annals of Allergy, Asthma & Immunology
Wen-Ya Lin, Lin-Shien Fu, Heng-Kuei Lin, Chian-Yin Shen, Yee-Jun Chen
INTRODUCTION: Dietary supplementation with probiotics alters intestinal microflora of children and may have immunomodulatory effects in prevention of allergic diseases. The aim of this study was to evaluate the effects of Lactobacillus paracasei (LP), strain HF.A00232, as a supplementary agent to levocetirizine in treating children with perennial allergic rhinitis (AR). METHODS: This study was a 12-week, double-blind, randomized, placebo-controlled trial. Sixty children with AR aged 6-13 years with nasal total symptoms score (NTSS) ≥5 who fulfilled the inclusion criteria were enrolled...
June 2014: Pediatrics and Neonatology
A Feliu, D González-de-Olano, E González, B Rodriguez, J Ruiz-Hornillos, L Jimeno, F de la Torre
BACKGROUND AND OBJECTIVE: In areas with a high number of allergens and high allergen concentrations, it is essential to identify the main causes of allergy, especially in pediatric patients. This study was conducted in allergic patients aged 14 or less to identify sensitization profiles during an initial phase, and to then evaluate changes in these profiles after 3 years of follow-up. This article describes the first phase of our investigation. METHODS: A total of 187 patients aged between 2 and 14 years were included by 5 allergy units; all the children had symptoms suggestive of allergic disease (rhinoconjunctivitis andlor asthma)...
2013: Journal of Investigational Allergology & Clinical Immunology
Arianna Dondi, Salvatore Tripodi, Valentina Panetta, Riccardo Asero, Andrea Di Rienzo Businco, Annamaria Bianchi, Antonio Carlucci, Giampaolo Ricci, Federica Bellini, Nunzia Maiello, Michele Miraglia del Giudice, Tullio Frediani, Simona Sodano, Iride Dello Iacono, Francesco Macrì, Valerio Massaccesi, Carlo Caffarelli, Laura Rinaldi, Maria Francesca Patria, Elena Varin, Diego Peroni, Iolanda Chinellato, Loredana Chini, Viviana Moschese, Sandra Lucarelli, Roberto Bernardini, Giuseppe Pingitore, Umberto Pelosi, Mariangela Tosca, Francesco Paravati, Stefania La Grutta, Paolo Meglio, Mauro Calvani, Mario Plebani, Paolo Maria Matricardi
BACKGROUND: Pollen-induced allergic rhinoconjunctivitis (AR) is highly prevalent and rapidly evolving during childhood. General practitioners may not be fully aware of the nature and severity of symptoms experienced by patients and might underestimate the prevalence of moderate or severe disease. Thus, the relevance of early diagnosis and intervention may be overlooked. OBJECTIVES: To investigate the severity of pollen-induced AR and its determinants in Italian children referred to allergy specialists and who had never received specific immunotherapy (SIT)...
December 2013: Pediatric Allergy and Immunology
Giovanni Melioli, Giovanni Passalacqua, Giorgio Walter Canonica, Carlos E Baena-Cagnani, Paolo Matricardi
PURPOSE OF REVIEW: The aim of this review is to update readers on the growing impact of a molecular approach (CRD) to the diagnosis and treatment of children with respiratory allergies RECENT FINDINGS: A large panel of highly purified natural or recombinant species-specific and cross-reacting allergenic molecules is now available for clinical purposes. Species-specific molecules allow identifying specific sensitization toward a given allergenic source. Cross-reacting molecules allow interpreting polysensitization patterns that cannot be detailed using routine skin prick tests or specific IgE tests based on allergenic extracts...
August 2013: Current Opinion in Allergy and Clinical Immunology
Julia M Kim, Sandra Y Lin, Catalina Suarez-Cuervo, Yohalakshmi Chelladurai, Murugappan Ramanathan, Jodi B Segal, Nkiruka Erekosima
BACKGROUND AND OBJECTIVE: Subcutaneous immunotherapy (SCIT) is approved in the United States for the treatment of pediatric asthma and rhinitis; sublingual immunotherapy (SLIT) does not have regulatory approval but is used in clinical practice. The objective of this study was to systematically review the evidence regarding the efficacy and safety of SCIT and SLIT for the treatment of pediatric asthma and allergic rhinoconjunctivitis. METHODS: Two independent reviewers selected articles for inclusion, extracted data, and graded the strength of evidence for each clinical outcome...
June 2013: Pediatrics
Ka-Kit Mak, Min-Sho Ku, Ko-Hsiu Lu, Hai-Lun Sun, Ko-Huang Lue
BACKGROUND: Various studies have investigated the efficacies of mometasone furoate monohydrate (MFM) and fluticasone propionate (FP) nasal sprays for adults. However, research on their effectiveness for children is limited. This study compares the efficacies of MFM and FP nasal sprays in pediatric patients with perennial-allergic rhinitis. MATERIALS AND METHODS: For this study, 94 perennial allergic rhinitis patients aged 6-12 years were randomly assigned to two treatment groups: an MFM group and an FP group...
August 2013: Pediatrics and Neonatology
Alessandra Scaparrotta, Marcello Verini, Nicola Pietro Consilvio, Anna Cingolani, Daniele Rapino, Marina Attanasi, Marzia Cerasa, Sabrina Di Pillo, Francesco Chiarelli
BACKGROUND: Grass pollens are significant elicitors of IgE-mediated allergic disease in the world and timothy (Phleum pratense) is one of the most important pollens of the family. Molecular and biochemical characterization of Phleum pratense has revealed several allergen components: rPhl p 1 and rPhl p 5 have been shown to be "Species Specific Allergens", while the profilin rPhl p 12 and the calcium-binding protein rPhl p 7 are the principal Cross-Reactive components. METHODS: In this study the pattern of sensitization to rPhl p 1, rPhl p 5, rPhl p 7 and rPhl p 12 was analyzed in children with asthma and/or rhinoconjunctivitis and grass pollen allergy, in order to evaluate the frequency of sensitization to allergenic molecules of Phleum pratense among pediatric subjects allergic to grass pollen in a Mediterranean population...
2013: Multidisciplinary Respiratory Medicine
Yun-Hu Wang, Min-Sho Ku, Hai-Lun Sun, Ko-Huang Lue
BACKGROUND: Nasal irrigation has been used as adjunctive therapy for sinonasal disease but is under-researched in children. The study aim was to evaluate the effectiveness of nasal irrigation with normal saline in the management of acute sinusitis in atopic children. METHODS: We enrolled 60 atopic children with acute sinusitis, of whom 29 received nasal irrigation with normal saline and 31 did not receive nasal irrigation. All participants underwent a nasal peak expiratory flow rate (nPEFR) test, a nasal smear examination, and radiography (Water's projection) and were requested to complete a Pediatric Rhinoconjunctivitis Quality-of-Life Questionnaire (PRQLQ) during the baseline visit...
February 2014: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
Dai Park, Nora Daher, Michael S Blaiss
Specific allergen immunotherapy has been practiced for allergic rhinoconjunctivitis for over 100 years and is the only treatment option that is disease modifying. In the USA, immunotherapy is usually administered via subcutaneous injection; this is the only route with a US FDA-approved formulation. There is growing interest in developing US-standardized formulations for the sublingual route, but up until recently there have been few US trials. Most of the experience with sublingual immunotherapy (SLIT) comes from Europe, where it is widely used and there is a large body of literature supporting its use...
August 2012: Expert Review of Clinical Immunology
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