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Maurizio Koch
Research in hepatology is booming. The spectrum of liver disease is very extensive. The recent advances in antiviral therapy have dramatically changed the clinical course of the diseases. This Editorial introduces the issue of Recenti Progressi in Medicina entirely focused on the near future of hepatology. Italian experts illustrate the forthcoming research and clinical innovation we should expect by 2020.
July 2016: Recenti Progressi in Medicina
Fabrizio Mecenate, Adriano M Pellicelli, Giuseppe Barbaro, Mario Romano, Angelo Barlattani, Ettore Mazzoni, Maria Elena Bonaventura, Lorenzo Nosotti, Pasquale Arcuri, Antonio Picardi, Giorgio Barbarini, Cecilia D'Ambrosio, Amerigo Paffetti, Arnaldo Andreoli, Fabrizio Soccorsi
BACKGROUND: In patients with chronic hepatitis C virus (HCV) genotype 2 or 3, 24 weeks' treatment with pegylated interferon alfa (PEG-IFN-alpha) and ribavirin induces a sustained virological response (SVR) in almost 80% of cases. Evidence suggests that a similar response rate may be obtained with shorter treatment periods, especially in patients with a rapid virological response (RVR). The aim of this study was to compare the efficacy of 12 or 24 weeks of treatment in patients with chronic HCV genotype 2 or 3 and to identify patients suitable for 12 weeks treatment...
2010: BMC Gastroenterology
Adriano M Pellicelli, Giuseppe Barbaro, Ruggiero Francavilla, Mario Romano, Giorgio Barbarini, Ettore Mazzoni, Fabrizio Mecenate, Amerigo Paffetti, Angelo Barlattani, Carlo Struglia, Roberto Villani, Leone Nauri, Lorenzo Nosotti, Orlando Armignacco, Fabrizio Ferri, Maria Pia Camporiondo, Fabrizio Soccorsi
OBJECTIVES: The aim of this study was to assess the therapeutic effectiveness of adefovir dipivoxil (ADV), administered in combination with lamivudine (LAM) or as monotherapy, and the rate of resistance to ADV, in hepatitis B e antigen (HBeAg)-negative adult patients with chronic hepatitis B virus (HBV) infection and clinical or virologic resistance to LAM. Furthermore, we evaluated in these selected patients the clinical co-variates associated with a sustained virologic response. METHODS: Data from adult outpatients aged >18 years with chronic HBV infection and clinical or virologic resistance to LAM were used in this retrospective, multicenter, nonrandomized, open-label study...
February 2008: Clinical Therapeutics
F D'Amore, A Agostino, A Santoro
We described two cases of drug-induced hepatitis: in both cases we recognised a pathogenesis based on hypersensivity mechanism. The first case, determined by naproxen, presented a serious cholestatic jaundice and histologic pattern due to ductular cholestasis without any inflammatory reaction. The second case, by a-metildopa, was characterized by spread necrosis of liver cells and peri-portal flogistic infiltrated. This chapter of modern epatology is becoming more and more important, because of both the opportunity of studyng physiopathologica mechanism and the increasing morbidity...
December 1996: Minerva Gastroenterologica e Dietologica
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