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https://www.readbyqxmd.com/read/29757870/changing-clinical-practice-evaluation-of-implementing-recommendations-for-opportunistic-salpingectomy-in-british-columbia-and-ontario
#1
Bryn Lander, Elizabeth Wilcox, Jessica N McAlpine, Sarah J Finlayson, David G Huntsman, Dianne Miller, Gillian E Hanley
OBJECTIVE: The aim of the study was to explore the factors that contributed to the adoption of opportunistic salpingectomies (removal of fallopian at the time of hysterectomy or in lieu of tubal ligation) by gynecologic surgeons in British Columbia (where a knowledge translation initiative took place) and in Ontario (a comparator where no knowledge translation initiative took place). We aimed to understand why the knowledge translation initiative undertaken by OVCARE in British Columbia resulted in such a dramatic uptake in opportunistic salpingectomy...
May 11, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29738336/in-vitro-antitumor-activity-of-new-quaternary-phosphonium-salts-derivatives-of-3-hydroxypyridine
#2
Alfiya G Iksanova, Raylya R Gabbasova, Tatyana V Kupriyanova, Almaz A Akhunzyanov, Michail V Pugachev, Ruzalia M Vafiva, Nikita V Shtyrlin, Konstantin V Balakin, Yurii G Shtyrlin
This work presents the results of in-vitro biological activity studies of three novel anticancer agents, phosphonium salts based on the 3-hydroxypyridine scaffold, including one derivative of 4-deoxypyridoxine. Proliferation and viability of cells treated with these compounds was assessed by the colony formation and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays. Effects of the compounds on apoptosis and cell cycle were studied by flow cytometry using annexin V-FITC/propidium iodide and propidium iodide staining, respectively...
May 5, 2018: Anti-cancer Drugs
https://www.readbyqxmd.com/read/29698921/design-synthesis-and-evaluation-of-novel-sulfonamides-as-potential-anticancer-agents
#3
Maryna V Kachaeva, Diana M Hodyna, Ivan V Semenyuta, Stepan G Pilyo, Volodymyr M Prokopenko, Vasyl V Kovalishyn, Larysa O Metelytsia, Volodymyr S Brovarets
Based on modern literature data about biological activity of E7010 derivatives, a series of new sulfonamides as potential anticancer drugs were rationally designed by QSAR modeling methods Сlassification learning QSAR models to predict the tubulin polymerization inhibition activity of novel sulfonamides as potential anticancer agents were created using the Online Chemical Modeling Environment (OCHEM) and are freely available online on OCHEM server at https://ochem.eu/article/107790. A series of sulfonamides with predicted activity were synthesized and tested against 60 human cancer cell lines with growth inhibition percent values...
April 10, 2018: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/29567272/the-bet-inhibitor-incb054329-reduces-homologous-recombination-efficiency-and-augments-parp-inhibitor-activity-in-ovarian-cancer
#4
Andrew J Wilson, Matthew Stubbs, Phillip Liu, Bruce Ruggeri, Dineo Khabele
OBJECTIVE: Homologous recombination (HR)-proficient ovarian tumors have poorer clinical outcomes and show resistance to poly ADP ribose polymerase inhibitors (PARPi). A subset of HR-proficient ovarian tumors show amplification in bromodomain and extra-terminal (BET) genes such as BRD4. We aimed to test the hypothesis that BRD4 inhibition sensitizes ovarian cancer cells to PARPi by reducing HR efficiency and increasing DNA damage. METHODS: HR-proficient ovarian cancer cell lines (OVCAR-3, OVCAR-4, SKOV-3, UWB1...
March 20, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29548784/high-expression-of-integrin-%C3%AE-v%C3%AE-3-enables-uptake-of-targeted-fluorescent-probes-into-ovarian-cancer-cells-and-tumors
#5
Scott K Shaw, Cynthia L Schreiber, Felicia M Roland, Paul M Battles, Seamus P Brennan, Simon J Padanilam, Bradley D Smith
The cell line OVCAR-4 was recently ranked as one of the most representative cell lines for high grade serous ovarian cancer (HGSOC). However, little work has been done to assess the susceptibility of OVCAR-4 cells and tumors to the more common types of molecular targeting. Proteome profiles suggest OVCAR-4 express high levels of integrin αvβ3 receptors. Using flow cytometry with fluorescent antibodies we determined that OVCAR-4 cells have high number of integrin αvβ3 receptors ([9.8 ± 2.5] × 104 /cell) compared to the well-characterized cell line U87-MG ([5...
May 1, 2018: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29519315/the-impact-of-regional-locality-on-chemical-composition-anti-oxidant-and-biological-activities-of-thymelaea-hirsuta-l-extracts
#6
Maroua Yahyaoui, Jalloul Bouajila, Sylvie Cazaux, Manef Abderrabba
BACKGROUND: Thymelaea hirsuta L. is a medicinal plant endemic to Tunisia, commonly used for its biological properties in traditional medicinal. PURPOSE: This study reports, to the best of our knowledge for the first time, the effect of regional location on the chemical composition, anti-oxidant and biological activities of organics extracts obtained from aerial parts of T. hirsuta. METHODS/STUDY DESIGN: The aerial parts collected from different locations were prepared by sequential method with solvents of increasing polarity namely hexane, ethyl acetate, ethanol and methanol...
March 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29459271/a-family-of-manganese-complexes-containing-heterocyclic-based-ligands-with-cytotoxic-properties
#7
Jessica Castro, Ester Manrique, Marlon Bravo, Maria Vilanova, Antoni Benito, Xavier Fontrodona, Montserrat Rodríguez, Isabel Romero
We describe the synthesis of three new manganese (II) complexes containing the bidentate ligands 2-(1-methyl-3-pyrazolyl)pyridine (pypz-Me) and ethyl 2-(3-(pyridine-2-yl)-1H-pyrazol-1-yl)acetate (pypz-CH2 COOEt), with formula [MnX2 (pypz-Me)2 ] (X = Cl- 1, CF3 SO3 - 2) and [Mn(CF3 SO3 )2 (pypz-CH2 COOEt)2 ] 3. Complexes 1-3 have been characterized through analytical, spectroscopic and electrochemical techniques, as well as by monocrystal X-ray diffraction analysis. The complexes show a six-coordinated Mn(II) ion though different stereoisomers have been isolated for the three compounds...
May 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29456106/design-synthesis-and-anticancer-activities-evaluation-of-novel-5h-dibenzo-b-e-azepine-6-11-dione-derivatives-containing-1-3-4-oxadiazole-units
#8
Xin He, Xin-Yang Li, Jing-Wei Liang, Chong Cao, Shuai Li, Ting-Jian Zhang, Fan-Hao Meng
Rucaparib and PJ34 were used as the structural model for the design of novel 5H-dibenzo[b,e]azepine-6,11-dione derivatives containing 1,3,4-oxadiazole units. And target compounds were successfully synthesized through a 3-step synthetic strategy. All target compounds were screened for their anti-proliferative effects against OVCAR-3 cell line. Preliminary biological study of these compounds provided potent compounds d21 and d22 with better activities than Rucaparib.
March 1, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29324532/low-expression-of-protocadherin-8-promotes-the-progression-of-ovarian-cancer
#9
Yuan Cao, Yan Yu, Xiaolong Chen, Fang Ren, Ruitao Zhang, Yanyan Jia, Zhigang Ren, Ranran Sun, Juan Li, Huirong Shi
OBJECTIVE: Ovarian cancer (OC) is the second most lethal gynecological cancer among women throughout the world. Protocadherin-8 (PCDH8) could function as a candidate tumor suppressor. However, the link between PCDH8 and OC development is poorly understood. MATERIALS AND METHODS: A total of 68 OC patients were retrospectively enrolled. Clinical information was collected and cancer tissues were used for tissue microarray. The PCDH8 expression was determined on tissue microarray by immunohistochemical staining, and PCDH8 protein was detected in cancer tissues and adjacent tissue by western blotting...
February 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29143360/identification-of-a-pyridine-derivative-inducing-senescence-in-ovarian-cancer-cell-lines-via-p21-activation
#10
Dongsheng Shang, Yanfang Wu, Ya Ding, Ziwen Lu, Yanting Shen, Feifei Zhu, Hanqing Liu, Chunyin Zhu, Zhigang Tu
Cellular senescence is a state of irreversible cell growth arrest. Increasing evidence suggests that cellular senescence contribute to tumour suppression in vivo. However, only a few anti-cancer drugs have been discovered to induce cellular senescence. Searching for new compounds which can inhibit cancer cell growth by inducing senescence is becoming one of the most attractive research fields. To test the effects of candidate compounds on cancer cell growth, cell proliferation assays, senescence-associated β-galactosidase (SA-β-gal) staining, and flow cytometry assay were performed...
May 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29070784/kaempferol-sensitizes-human-ovarian-cancer-cells-ovcar-3-and-skov-3-to-tumor-necrosis-factor-related-apoptosis-inducing-ligand-trail-induced-apoptosis-via-jnk-erk-chop-pathway-and-up-regulation-of-death-receptors-4-and-5
#11
Yingmei Zhao, Binqiang Tian, Yong Wang, Haiying Ding
BACKGROUND Ovarian cancer is the most common gynecological malignancies in women, with high mortality rates worldwide. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the tumor necrosis factor (TNF) superfamily which preferentially induces apoptosis of cancer cells. However, acquired resistance to TRAIL hampers its therapeutic application. Identification of compounds that sensitize cancer cells to TRAIL is vital in combating resistance to TRAIL. The effect of kaempferol, a flavonoid enhancing TRAIL-induced apoptosis in ovarian cancer cells, was investigated in this study...
October 26, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28936921/osteopontin-c-isoform-levels-are-associated-with-sr-and-hnrnp-differential-expression-in-ovarian-cancer-cell-lines
#12
Durval Santos Marques, Jessica Grativol, Rodrigo Alves da Silva Peres, Aline da Rocha Matos, Etel Rodrigues Pereira Gimba
Osteopontin-c splicing isoform activates ovarian cancer progression features. Imbalanced expression of splicing factors from serine/arginine -rich and heterogeneous ribonucleoproteins families has been correlated with the generation of oncogenic splicing isoforms. Our goal was to investigate whether there is any association between the transcriptional patterns of these splicing factors in ovarian cells and osteopontin-c expression levels. We also aimed to investigate the occurrence of these splicing factors binding sites inside osteopontin exon 4 and adjacent introns...
September 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28912871/paeonol-enhances-the-sensitivity-of-human-ovarian-cancer-cells-to-radiotherapy-induced-apoptosis-due-to-downregulation-of-the-phosphatidylinositol-3-kinase-akt-phosphatase-and-tensin-homolog-pathway-and-inhibition-of-vascular-endothelial-growth-factor
#13
Hai-Mei Zhou, Qin-Xiang Sun, Yan Cheng
Radiotherapy is a vital and effective method to treat solid tumors. However, in many tumor types, development of resistance of cancer cells and cytotoxicity in normal tissues presents a major therapeutic problem. It is therefore crucial to identify and develop novel sensitizing agents that may improve the response to radiation therapy without causing any adverse effects. The present study aimed to investigate whether paeonol, a bioactive flavonoid, was able to confer sensitivity to radiation in human ovarian cancer cells...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28872817/carboplatin-loaded-raman-encoded-chitosan-coated-silver-nanotriangles-as-multimodal-traceable-nanotherapeutic-delivery-systems-and-ph-reporters-inside-human-ovarian-cancer-cells
#14
Monica Potara, Timea Nagy-Simon, Ana Maria Craciun, Sorina Suarasan, Emilia Licarete, Florica Imre-Lucaci, Simion Astilean
Ovarian cancer is a common cause of cancer death in women and is associated with the highest mortality rates of all gynecological malignancies. Carboplatin (CBP) is the most used cytotoxic agent in the treatment of ovarian cancer. Herein, we design and assess a CBP nanotherapeutic delivery system which allows combinatorial functionalities of chemotherapy, pH sensing, and multimodal traceable properties inside live NIH:OVCAR-3 ovarian cancer cells. In our design, a pH-sensitive Raman reporter, 4-mercaptobenzoic acid (4MBA) is anchored onto the surface of chitosan-coated silver nanotriangles (chit-AgNTs) to generate a robust surface-enhanced Raman scattering (SERS) traceable system...
September 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28861582/a-systems-biology-approach-to-identify-micrornas-contributing-to-cisplatin-resistance-in-human-ovarian-cancer-cells
#15
Weisha Liu, Shuyuan Wang, Shunheng Zhou, Feng Yang, Wei Jiang, Qingyuan Zhang, Lihong Wang
Cisplatin (CDDP)-based chemotherapy is a standard first-line therapy for ovarian cancer. However, drug resistance remains a major obstacle to its efficacy. Recently, increasing evidence suggested that the aberrant expression of microRNAs (miRNAs) may contribute to drug resistance. Here, we proposed a systems biology analysis strategy to identify the novel miRNAs potentially involved in CDDP resistance in human ovarian cancer cells. Firstly, we identified the candidate miRNAs associated with CDDP resistance using NCI-60 data...
October 24, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28796092/oral-administration-of-clinical-stage-drug-candidate-sens-401-effectively-reduces-cisplatin-induced-hearing-loss-in-rats
#16
Mathieu Petremann, Christophe Tran Van Ba, Audrey Broussy, Charlotte Romanet, Jonas Dyhrfjeld-Johnsen
HYPOTHESIS: SENS-401, an oral clinical-stage drug, may reduce cisplatin-induced hearing loss and cochlear damage in an in vivo model. BACKGROUND: Cisplatin is commonly associated with hearing loss, causing significant learning and behavioral difficulties in the pediatric cancer population, and for which there are currently no clinical solutions. SENS-401 has previously been shown to improve acoustic trauma-induced hearing loss in vivo. METHODS: The effect of SENS-401 (R-azasetron besylate) on cisplatin IC50 values was evaluated in a panel of cisplatin-sensitive cell lines (NIH:OVCAR-3, SK-N-AS, NCI-H460, FaDu)...
October 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28719026/in-vitro-antiproliferative-and-antibacterial-activities-of-essential-oils-from-four-species-of-guatteria
#17
Anderson R Santos, Thalita Gilda S Benghi, Angelita Nepel, Francisco A Marques, Adriana Q Lobão, Marta Cristina T Duarte, Ana Lúcia T G Ruiz, João E Carvalho, Beatriz H L N S Maia
The essential oils (EOs) extracted from four species of the genus Guatteria, G. australis, G. ferruginea, G. latifolia, and G. sellowiana were analyzed. A total of 24, 22, 25, and 19 constituents of the oils from four species, respectively, were identified by GC/MS. These oils showed qualitative and quantitative differences. All the oils contained the oxygenated sesquiterpenes spathulenol (11.04 - 40.29%) and caryophyllene oxide (7.74 - 40.13%) as predominant constituents. Evaluation of antiproliferative activity of the EOs showed strong selectivity (1...
October 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28710496/dietary-geranylgeraniol-can-limit-the-activity-of-pitavastatin-as-a-potential-treatment-for-drug-resistant-ovarian-cancer
#18
Elizabeth de Wolf, Marwan Ibrahim Abdullah, Stefanie M Jones, Karen Menezes, Darren M Moss, Falko P Drijfhout, Sarah R Hart, Clare Hoskins, Euan A Stronach, Alan Richardson
Pre-clinical and retrospective studies of patients using statins to reduce plasma cholesterol have suggested that statins may be useful to treat cancer. However, prospective clinical trials have yet to demonstrate significant efficacy. We have previously shown that this is in part because a hydrophobic statin with a long half-life is necessary. Pitavastatin, the only statin with this profile, has not undergone clinical evaluation in oncology. The target of pitavastatin, hydroxymethylglutarate coenzyme-A reductase (HMGCR), was found to be over-expressed in all ovarian cancer cell lines examined and upregulated by mutated TP53, a gene commonly altered in ovarian cancer...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28654762/jatropha-6-17-11e-diene-class-derivatives-induce-apoptosis-effects-in-ovcar-3-and-caov-4-ovarian-cancer-cell-lines-via-a-mitochondrial-pathway
#19
Behzad Bahmani, Mohammad Keyvanloo Shahrestanaki, Mustafa Ghanadian, Sima Hajiahmadi, Mahmoud Aghaei
We investigated the molecular mechanism of apoptosis induced by novel jatropha-6(17),11E-diene class derivatives, compounds A, B, and C that were extracted from Euphorbia osyridea Boiss, in the ovarian cancer cell lines Caov-4 and OVCAR-3. The OVCAR-3 and Caov-4 cell lines were treated with different concentrations of these compounds. Cytotoxicity was evaluated using MTT, clonogenic survival assay, and flow cytometry assays. The production of reactive oxygen species (ROS), mitochondrial membrane potential (ΔΨm ), and the activity of caspase 3 and 9 were evaluated...
December 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28649078/3-4-chlorophenyl-1-2-3-oxadiazol-3-ium-5-olate-and-its-4-formyl-analog-ultrasound-assisted-synthesis-and-in-vitro-anticancer-evaluation-against-human-tumor-cell-lines
#20
Sachin K Bhosale, Shreenivas R Deshpande, Rajendra D Wagh
The title compound, 3-(4-chlorophenyl)-4-formyl-[1, 2, 3] oxadiazol-3-ium-5-olate 5 was synthesized under ultrasonication by formylation of 3-(4-chlorophenyl)-[1, 2, 3] oxadiazol-3-ium-5-olate 4 and characterized by spectral studies. The ultrasonic method of synthesis was found to be simple, ecofriendly, economical, reduces reaction time and gave good yield when compared with traditional methods of synthesis. Anticancer activity of the compounds were tested against 60 human tumor cell lines and compared with standard drug vincristine sulphate...
March 2017: Pakistan Journal of Pharmaceutical Sciences
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