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https://www.readbyqxmd.com/read/28655214/nutritional-value-chemical-composition-and-antioxidant-activity-of-three-tuber-species-from-china
#1
Xiangyuan Yan, Yanwei Wang, Xiaoyu Sang, Li Fan
Nutritional value, chemical composition and antioxidant activity of the traditional edible truffles Tuber latisporum, T. subglobosum and T. pseudohimalayense, from China were evaluated. Powder formulations of the three truffles revealed the presence of essential nutrients, such as proteins, carbohydrates and unsaturated fatty acids, and T. latisporum presented the highest contents of total sugar (50.10 g/100 g) and monounsaturated fatty acids (265.19 mg/100 g dw); T. pseudohimalayense showed the highest content of polyunsaturated fatty acids (367...
December 2017: AMB Express
https://www.readbyqxmd.com/read/28655201/unplanned-reoperation-after-craniotomy-for-tumor-a-national-surgical-quality-improvement-program-analysis
#2
Hormuzdiyar H Dasenbrock, Sandra C Yan, Vamsi Chavakula, William B Gormley, Timothy R Smith, Elizabeth B Claus, Ian F Dunn
BACKGROUND: Reoperation has been increasingly utilized as a metric evaluating quality of care. OBJECTIVE: To evaluate the rate of, reasons for, and predictors of unplanned reoperation after craniotomy for tumor in a nationally accrued population. METHODS: Patients who underwent cranial tumor resection were extracted from the prospective National Surgical Quality Improvement Program registry (2012-2014). Multivariate logistic regression examined predictors of unplanned cranial reoperation...
June 26, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28655145/partitioned-learning-of-deep-boltzmann-machines-for-snp-data
#3
Moritz Hess, Stefan Lenz, Tamara J Blätte, Lars Bullinger, Harald Binder
Motivation: Learning the joint distributions of measurements, and in particular identification of an appropriate low-dimensional manifold, has been found to be a powerful ingredient of deep leaning approaches. Yet, such approaches have hardly been applied to single nucleotide polymorphism (SNP) data, probably due to the high number of features typically exceeding the number of studied individuals. Results: After a brief overview of how deep Boltzmann machines (DBMs), a deep learning approach, can be adapted to SNP data in principle, we specifically present a way to alleviate the dimensionality problem by partitioned learning...
June 26, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28655130/comparison-of-biochemical-parameters-of-blood-and-urine-in-spinal-cord-injury-patients-and-association-with-urinary-stone-formation
#4
Gülümser Aydin, Sibel Özbudak Demir, Timur Ekiz, Murat I Nanir, Aliye Tosun
OBJECTIVE: The aim of this study was to compare the biochemical parameters of the urine and blood in SCI patients and healthy subjects. METHODS: Thirty male patients with SCI were enrolled. Biochemical features of the urine and blood of the SCI patients were compared to healthy subjects. Extracted stones were analyzed by X-ray diffraction. RESULTS: A total of 30 patients with SCI (mean age of 28.77 ± 7.3 years) and 10 healthy subjects (mean age of 27...
June 3, 2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/28655072/oral-administration-of-glycine-and-leucine-dipeptides-improves-skin-hydration-and-elasticity-in-uvb-irradiated-hairless-mice
#5
Jong Il Park, Ji Eun Lee, Hyun Jun Shin, Soonran Song, Won Kyung Lee, Jae Sung Hwang
Placenta is a special organ that contains many nutrients such as growth factors, minerals, and bioactive peptides. Dipeptides of glycine and leucine are major components of porcine placenta extracts (PPE) that has been used as an alternative of human placenta extracts. In this study, we investigated whether major peptides of PPE, Glycyl-L-Leucine (Gly-Leu), L-Leucyl-Glycine (Leu-Gly), and L-Leucyl-L-Leucine (Leu-Leu), affect skin hydration and elasticity in vitro and in vivo. We found that Gly-Leu and Leu-Gly dipeptides induced the expression of transglutaminase 1 in normal human epidermal keratinocytes (NHEKs) whereas Leu-Leu dipeptides did not...
June 27, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/28654941/internally-versus-externally-cued-speech-in-parkinson-s-disease-and-cerebellar-disease
#6
Phil Weir-Mayta, Kristie A Spencer, Tanya L Eadie, Kathryn Yorkston, Sara Savaglio, Chris Woollcott
Purpose: The purpose of this study was to examine the effects of an internally versus externally cued speech task on perceived understandability and naturalness in speakers with Parkinson's disease (PD) and cerebellar disease (CD). Method: Sentences extracted from a covertly recorded conversation (internally cued) were compared to the same sentences read aloud (externally cued) by speakers with PD and a clinical comparison group of speakers with CD. Experienced listeners rated the speech samples using a visual analog scale for the perceptual dimensions of understandability and naturalness...
June 22, 2017: American Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/28654920/greater-real-life-diagnostic-efficacy-of-allergen-molecule-based-diagnosis-for-prescription-of-immunotherapy-in-an-area-with-multiple-pollen-exposure
#7
Ulbosin Saltabayeva, Viktoriya Garib, Marina Morenko, Rafail Rosenson, Zhanat Ispayeva, Madina Gatauova, Loreta Zulus, Aleksandr Karaulov, Felix Gastager, Rudolf Valenta
BACKGROUND: Allergen molecule-based diagnosis has been suggested to facilitate the identification of disease-causing allergen sources and the prescription of allergen-specific immunotherapy (AIT). The aim of the current study was to compare allergen molecule-based IgE serology with allergen extract-based skin testing for the identification of the disease-causing allergen sources. The study was conducted in an area where patients are exposed to pollen from multiple sources (trees, grasses, and weeds) at the same time to compare the diagnostic efficiency of the 2 forms of diagnosis...
June 28, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28654902/cryptotanshinone-inhibits-proliferation-yet-induces-apoptosis-by-suppressing-stat3-signals-in-renal-cell-carcinoma
#8
Zhiguo Chen, Rujian Zhu, Jiayi Zheng, Chen Chen, Chi Huang, Junjie Ma, Chen Xu, Wei Zhai, Junhua Zheng
It has been established that signal transducer and activator of transcription 3 serves as an oncoprotein in various human cancers; targeting it is therefore a reasonable approach for emerging cancer therapies. Cryptotanshinone, a natural compound extracted from the root of Salvia miltiorrhiza Bunge, has been identified as a potential STAT3 inhibitor. However, its functional role in renal cell carcinomas remains largely unknown. Therefore, we investigated the mode of action for cryptotanshinone. We found that cryptotanshinone substantially suppressed cancer cell growth while it promoted cell apoptosis by inhibiting the phosphorylation of STAT3 at Tyr705 and its blocking nuclear translocation...
June 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28654879/geochemical-phase-and-particle-size-relationships-of-metals-in-urban-road-dust
#9
Ayomi Jayarathne, Prasanna Egodawatta, Godwin A Ayoko, Ashantha Goonetilleke
Detailed knowledge of the processes that metals undergo during dry weather periods whilst deposited on urban surfaces and their environmental significance is essential to predict the potential influence of metals on stormwater quality in order to develop appropriate stormwater pollution mitigation measures. However, very limited research has been undertaken in this area. Accordingly, this study investigated the geochemical phase and particle size relationships of seven metals which are commonly associated with urban road dust, using sequential extraction in order to assess their mobility characteristics...
June 24, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28654870/twenty-years-of-take-home-naloxone-for-the-prevention-of-overdose-deaths-from-heroin-and-other-opioids-conception-and-maturation
#10
REVIEW
Rebecca McDonald, Nancy D Campbell, John Strang
BACKGROUND: Opioid overdose is a major cause of mortality, but injury and fatal outcomes can be prevented by timely administration of the opioid antagonist naloxone. Pre-provision of naloxone to opioid users and family members (take-home naloxone, THN) was first proposed in 1996, and WHO Guidelines were issued in 2014. While widespread in some countries, THN is minimally available or absent elsewhere. This review traces the development of THN over twenty years, from speculative harm reduction proposal to public health strategy...
May 25, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28654868/simultaneous-assessment-of-absorption-characteristics-of-coumarins-from-angelicae-pubescentis-radix-in-vitro-transport-across-caco-2-cell-and-in-vivo-pharmacokinetics-in-rats-after-oral-administration
#11
Yan-Fang Yang, Lei Zhang, You-Bo Zhang, Xiu-Wei Yang
Angelicae Pubescentis Radix (APR), a well-known traditional Chinese medicine, is widely used for the treatments of rheumatism and headache for centuries. To assess the absorption characteristics of coumarins from APR, a sensitive and reliable UPLC-MS/MS method was established for the simultaneous determination of sixteen coumarins from APR, including psoralen, xanthotoxin, bergapten, bergaptol, isoimperatorin, imperatorin, columbianetin, columbianetin acetate, columbianadin, oxypeucedanin hydrate, angelol B, umbelliferone, scopoletin, osthole, meranzin hydrate and nodakenetin...
June 13, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28654806/ginger-extract-mitigates-ethanol-induced-changes-of-alpha-and-beta-myosin-heavy-chain-isoforms-gene-expression-and-oxidative-stress-in-the-heart-of-male-wistar-rats
#12
Alireza Shirpoor, Mitra Zerehpoosh, Mohammad Hasan Khadem Ansari, Fatemeh Kheradmand, Yousef Rasmi
The association between ethanol consumption and heart abnormalities, such as chamber dilation, myocyte damage, ventricular hypertrophy, and hypertension is well known. However, underlying molecular mediators involved in ethanol-induced heart abnormalities remain elusive. The aim of this study was to investigate the effect of chronic ethanol exposure on alpha and beta - myosin heavy chain (MHC) isoforms gene expression transition and oxidative stress in rats' heart. It was also planned to find out whether ginger extract mitigated the abnormalities induced by ethanol in rats' heart...
June 21, 2017: DNA Repair
https://www.readbyqxmd.com/read/28654794/preclinical-evidence-of-the-anxiolytic-and-sedative-like-activities-of-tagetes-erecta-l-reinforces-its-ethnobotanical-approach
#13
Gimena Pérez-Ortega, Guadalupe Esther Angeles-López, Arturo Argueta-Villamar, María Eva González-Trujano
Morelos State is one of the regions of Mexico where several plant species are used in traditional medicine. Species from Tagetes genus (Asteraceae) are reported as useful in infusion to treat stomachache and intestinal diseases, but also as tranquilizers. In this study, medicinal uses of T. erecta including its depressant effect on the central nervous system (CNS) were explored by interviewing healers and merchants of local markets of Morelos State, and by investigation of the phytochemical and pharmacological tranquilizing properties...
June 24, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28654792/age-related-plantar-centre-of-pressure-trajectory-changes-during-barefoot-walking
#14
Gisela Sole, Todd Pataky, Christopher C Sole, Leigh Hale, Stephan Milosavljevic
Plantar centre of pressure (COP) variables during gait have been used to predict risk of injury, or consequences thereof. The aim of this study was to determine the effect of age on the COP trajectory during barefoot gait at a self-selected speed. 287 participants (aged 18-80year, 163 women) walked barefoot at self-selected speed across a Footscan(®) force platform, completing five trials for each side. COP trajectories were extracted and trajectory-level canonical correlation analysis was used to test their correlation with age...
June 21, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28654768/a-systematic-review-of-sexual-and-reproductive-health-care-content-in-nursing-curricula
#15
Joyce Cappiello, Leah Coplon, Holly Carpenter
OBJECTIVE: To examine whether and to what extent pre-licensure nursing programs include sexual and reproductive health (SRH) content in their curricula. DATA SOURCES: Electronic databases, including CINAHL, MEDLINE, PubMed, Web of Science, Science Direct, Google Scholar, ProQuest, and CAB Direct were searched for relevant literature. We also reviewed the reference lists of all studies, nursing organization Web sites, and the personal files of the authors. STUDY SELECTION: Inclusion criteria were studies focused on SRH content in pre-licensure nursing education, written in English, and published between January 1990 and November 2016...
June 24, 2017: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
https://www.readbyqxmd.com/read/28654762/jatropha-6-17-11e-diene-class-derivatives-induce-apoptosis-effects-in-ovcar-3-and-caov-4-ovarian-cancer-cell-lines-via-mitochondrial-pathway
#16
Behzad Bahmani, Mohammad Keyvanloo Shahrestanaki, Mustafa Ghanadian, Sima Hajiahmadi, Mahmoud Aghaei
We investigated the molecular mechanism of apoptosis induced by novel jatropha-6(17),11E-diene class derivatives, compounds A, B, and C extracted from Euphorbia osyridea in Caov-4 and OVCAR-3 ovarian cancer cell lines. OVCAR-3 and Caov-4 cell lines were treated with different concentrations of these compounds. Cytotoxicity was evaluated by MTT, clonogenic survival assay and Flow cytometry assays. ROS production, mitochondrial membrane potential (ΔΨm), Caspase 3 and 9 activities were evaluated. Compound A, B, and C reduced cell viability in a dose-dependent manner (P<0...
June 27, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28654718/building-connectomes-using-diffusion-mri-why-how-and-but
#17
Stamatios N Sotiropoulos, Andrew Zalesky
Why has diffusion MRI become a principal modality for mapping connectomes in vivo? How do different image acquisition parameters, fiber tracking algorithms and other methodological choices affect connectome estimation? What are the main factors that dictate the success and failure of connectome reconstruction? These are some of the key questions that we aim to address in this review. We provide an overview of the key methods that can be used to estimate the nodes and edges of macroscale connectomes, and we discuss open problems and inherent limitations...
June 27, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28654654/identification-and-characterization-of-acka-dependent-protein-acetylation-in-neisseria-gonorrhoeae
#18
Deborah M B Post, Birgit Schilling, Lorri M Reinders, Alexandria K D'Souza, Margaret R Ketterer, Steven J Kiel, Aroon T Chande, Michael A Apicella, Bradford W Gibson
Neisseria gonorrhoeae, the causative agent of gonorrhea, has a number of factors known to contribute to pathogenesis; however, a full understanding of these processes and their regulation has proven to be elusive. Post-translational modifications (PTMs) of bacterial proteins are now recognized as one mechanism of protein regulation. In the present study, Western blot analyses, with an anti-acetyl-lysine antibody, indicated that a large number of gonococcal proteins are post-translationally modified. Previous work has shown that Nε-lysine acetylation can occur non-enzymatically with acetyl-phosphate (AcP) as the acetyl donor...
2017: PloS One
https://www.readbyqxmd.com/read/28654653/validity-of-using-multiple-imputation-for-unknown-stage-at-diagnosis-in-population-based-cancer-registry-data
#19
Qingwei Luo, Sam Egger, Xue Qin Yu, David P Smith, Dianne L O'Connell
BACKGROUND: The multiple imputation approach to missing data has been validated by a number of simulation studies by artificially inducing missingness on fully observed stage data under a pre-specified missing data mechanism. However, the validity of multiple imputation has not yet been assessed using real data. The objective of this study was to assess the validity of using multiple imputation for "unknown" prostate cancer stage recorded in the New South Wales Cancer Registry (NSWCR) in real-world conditions...
2017: PloS One
https://www.readbyqxmd.com/read/28654642/monitoring-of-noble-signal-and-narrow-clawed-crayfish-using-environmental-dna-from-freshwater-samples
#20
Sune Agersnap, William Brenner Larsen, Steen Wilhelm Knudsen, David Strand, Philip Francis Thomsen, Martin Hesselsøe, Peter Bondgaard Mortensen, Trude Vrålstad, Peter Rask Møller
For several hundred years freshwater crayfish (Crustacea-Decapoda-Astacidea) have played an important ecological, cultural and culinary role in Scandinavia. However, many native populations of noble crayfish Astacus astacus have faced major declines during the last century, largely resulting from human assisted expansion of non-indigenous signal crayfish Pacifastacus leniusculus that carry and transmit the crayfish plague pathogen. In Denmark, also the non-indigenous narrow-clawed crayfish Astacus leptodactylus has expanded due to anthropogenic activities...
2017: PloS One
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