Ashley S Meakin, Melanie Smith, Janna L Morrison, Claire T Roberts, Martha Lappas, Stacey J Ellery, Olivia Holland, Anthony Perkins, Sharon A McCracken, Vicki Flenady, Vicki L Clifton
A birthweight centile (BWC) below the 25th is associated with an elevated risk of adverse perinatal outcomes, particularly among males. This male vulnerability may stem from alterations in placenta-specific androgen signalling, a signalling axis that involves the androgen receptor (AR)-mediated regulation of target genes containing androgen response elements (AREs). In this study, we examined global and ARE-specific transcriptomic signatures in term male placentae (≥37 weeks of gestation) across BWC subcategories (<10th, 10th-30th, >30th) using RNA-seq and gene set enrichment analysis...
January 30, 2024: International Journal of Molecular Sciences