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Jt interval

J S Floyd, C M Sitlani, C L Avery, R Noordam, X Li, A V Smith, S M Gogarten, J Li, L Broer, D S Evans, S Trompet, J A Brody, J D Stewart, J D Eicher, A A Seyerle, J Roach, L A Lange, H J Lin, J A Kors, T B Harris, R Li-Gao, N Sattar, S R Cummings, K L Wiggins, M D Napier, T Stürmer, J C Bis, K F Kerr, A G Uitterlinden, K D Taylor, D J Stott, R de Mutsert, L J Launer, E L Busch, R Méndez-Giráldez, N Sotoodehnia, E Z Soliman, Y Li, Q Duan, F R Rosendaal, P E Slagboom, K C Wilhelmsen, A P Reiner, Y-DI Chen, S R Heckbert, R C Kaplan, K M Rice, J W Jukema, A D Johnson, Y Liu, D O Mook-Kanamori, V Gudnason, J G Wilson, J I Rotter, C C Laurie, B M Psaty, E A Whitsel, L A Cupples, B H Stricker
Sulfonylureas, a commonly used class of medication used to treat type 2 diabetes, have been associated with an increased risk of cardiovascular disease. Their effects on QT interval duration and related electrocardiographic phenotypes are potential mechanisms for this adverse effect. In 11 ethnically diverse cohorts that included 71 857 European, African-American and Hispanic/Latino ancestry individuals with repeated measures of medication use and electrocardiogram (ECG) measurements, we conducted a pharmacogenomic genome-wide association study of sulfonylurea use and three ECG phenotypes: QT, JT and QRS intervals...
December 13, 2016: Pharmacogenomics Journal
Hande Ozportakal, Abdullah Ozkok, Ozlem Alkan, Ahmet Sait Bulut, Memduha Boyraz, Mehmet Inanir, Goksel Acar, Ali Riza Odabas
PURPOSE: Hemodialysis (HD) patients are known to have high cardiovascular mortality rate. Sudden cardiac death (SCD) due to arrhythmias causes most of the cardiac deaths. HD per se may lead to ECG abnormalities and ventricular arrhythmias. Monitoring ECG parameters such as corrected QT interval, QT dispersion (QTd), Tpe interval may be useful to stratify the patients with high risk of arrhythmia and SCD. Herein we aimed to investigate the effects of changes in serum electrolyte levels and pH on ECG parameters before and after the HD...
December 10, 2016: International Urology and Nephrology
Stephan Hohmann, Boris Rudic, Torsten Konrad, David Duncker, Thorben König, Erol Tülümen, Thomas Rostock, Martin Borggrefe, Christian Veltmann
AIMS: Overlap syndromes of long QT 3 syndrome (LQT3) and the Brugada syndrome (BrS) have been reported. Identification of patients with an overlapping phenotype is crucial before initiation of Class I antiarrhythmic drugs for LQT3. Aim of the present study was to elucidate the yield of ajmaline challenge in unmasking the Brugada phenotype in patients with LQT3 caused by the most common mutation, SCN5A-E1784K. METHODS AND RESULTS: Consecutive families in tertiary referral centres diagnosed with LQT3 caused by SCN5A-E1784K were included in the study...
December 2, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Mohamed F Lutfi
Previous studies assessing effect of ischemia on ventricular repolarization are mostly directed toward patients with coronary artery disease (CAD); however, similar reports on cardiac syndrome X (CSX) are scarce. Whether microvascular dysfunction of CSX and ischemia induced by CAD produce comparable effect on ventricular repolarization is unclear and deserve further studies. In the present study, ECG measures of ventricular repolarization were compared between CAD and CSX patients (40 subjects in each group)...
2016: Frontiers in Physiology
Lichun Wang, Jingzhou Jiang, Chen Su, Chong Feng, Yili Chen, Jun Liu, Jiangui He, Anli Tang
PURPOSE: Differentiating between atrioventricular nodal reentrant tachycardia (AVNRT) and non-reentrant junctional tachycardia (JT) is difficult but highly necessary for catheter ablation. The purpose of this study was to investigate whether the ventriculoatrial (VA) relationship after atrial overdrive pacing (AOP) could help to distinguish AVNRT from JT. METHODS: Thirty-eight AVNRT and 21 JT patients who were induced by infusion of isoproterenol after successful AVNRT ablation were paced through the high right atrium or coronary sinus until the ventricles were constantly captured...
December 2016: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
Aisha K Lofters, Sara Jt Guilcher, Lauren Webster, Richard H Glazier, Susan B Jaglal, Ahmed M Bayoumi
PURPOSE: Despite more frequent use of health services by people living with disability, the quality of preventive care received may be suboptimal. In this retrospective cohort study, we used administrative data to examine the relationship between cholesterol testing and levels of disability and morbidity among women and men in Ontario, Canada. METHODS: We linked multiple provincial-level databases in this study. In stratified analyses for women and men, we used multivariable logistic regression to examine differences in cholesterol testing, and we tested for an interaction effect between disability and morbidity...
2016: Clinical Epidemiology
Markus Pirlich, Mary Tittmann, Daniela Franz, Andreas Dietz, Mathias Hofer
"CI-Wizard" is a new, three-dimensional software planning tool for cochlear implant surgery with manual and semi-automatic algorithms to visualize anatomical risk structures of the lateral skull base preoperatively. Primary endpoints of the study represented the evaluation of the CI-Wizards usability, accuracy, subjectively perceived and objectively measured time in clinical practice. In a period from January 2014 to March 2015, n = 36 participants were included in this study. These members were divided into three groups of equal number (n = 12), but different level of experience...
September 2, 2016: European Archives of Oto-rhino-laryngology
Hidetoshi Uchida, Miki Nishio, Yumi Omeki, Yuka Takeuchi, Rina Nagata, Shota Oikawa, Arisa Nagatani, Yoshihiko Eryu, Tadayoshi Hata, Tetsushi Yoshikawa
: In patients with a ventricular septal defect, left-to-right shunting increases the left ventricular preload. This pathological change affects myocardial depolarization and repolarization and has the potential to evoke arrhythmogenic substrates. We examined the effect of ventricular septal defects on myocardial repolarization by investigating the variability in the repolarization interval. This retrospective study included 19 patients (mean age, 1.8 ± 2.1 years) who underwent surgical closure (mean left-to-right shunt ratio, 2...
December 2016: Pediatric Cardiology
Behnam Tajik, Sudhir Kurl, Tomi-Pekka Tuomainen, Jyrki K Virtanen
PURPOSE: Long-chain omega-3 polyunsaturated fatty acids (PUFA) from fish have been associated with risk of cardiovascular diseases (CVD), especially sudden cardiac death (SCD). Mercury exposure, mainly due fish consumption, has been associated with higher risk. However, the impact of PUFAs or mercury on the ventricular cardiac arrhythmias, which often precede SCD, is not completely known. We investigated the associations of the serum long-chain omega-3 PUFAs and hair mercury with ventricular repolarization, measured by heart rate-corrected QT and JT intervals (QTc and JTc, respectively)...
July 18, 2016: European Journal of Nutrition
Fernanda Justo, Henrique Fuller, Bruce D Nearing, Sridharan Rajamani, Luiz Belardinelli, Richard L Verrier
BACKGROUND: Myocardial ischemia carries dual risk for initiating atrial and ventricular arrhythmias that can be exacerbated by adrenergic stimulation. OBJECTIVE: The purpose of this study was to investigate whether selective inhibition of the cardiac late sodium current (INa) with eleclazine decreases susceptibility to ischemia-induced atrial fibrillation (AF) and atrial and ventricular repolarization abnormalities before and after epinephrine infusion. METHODS: In chloralose-anesthetized, open-chest, male Yorkshire pigs (n = 12), atrial and ventricular ischemia was induced by partial occlusion of the left circumflex coronary artery proximal segment to reduce flow by 75%...
September 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Elaine Hyshka, Jalene Tayler Anderson, T Cameron Wild
INTRODUCTION AND AIMS: Research on perceived unmet need for care for mental health and substance use problems focuses on general populations to the detriment of hidden populations. This study describes prevalence and correlates of perceived unmet need for care in a community-based sample of street-involved people who use illicit drugs and identifies barriers to care. DESIGN AND METHODS: A sample of 320 street-involved people who use drugs participated in a structured, interviewer-assisted survey in Edmonton, Canada...
May 30, 2016: Drug and Alcohol Review
James T Webb, Thomas R Morgan, Sean D Sarsfield
INTRODUCTION: Earlier research described a linear relationship between the highest 1 min of oxygen consumption (Vo2) during a recurring physical activity and incidence of decompression sickness (DCS) during research chamber exposures to high altitude. The current effort was designed to determine if that relationship holds true at a lower altitude. METHODS: Male subjects (20) were exposed without prebreathe to 22,500 ft (6858 m; 314 mmHg; 6.1 psi) for 4 h while seated, nonambulatory the entire time, with echo-imaging at 16-min intervals (Non-Amb Echo), breathing 100% oxygen...
June 2016: Aerospace Medicine and Human Performance
Marjeta Misigoj-Durakovic, Zijad Durakovic, Ivan Prskalo
In literature, data on the prevalence of prolonged and shortened corrected QT (QTc) have shown considerable variability. The aim of the study was to compare QTc and JTc intervals of competitive student athletes and noncompetitive sport participants to QTc cutoff points used in athletes. A group of 485 physically fit candidates for the study of kinesiology (139 female and 346 male candidates) aged 18-20 participated in the study. Basic anthropometry, field fitness test, cardiovascular, electrocardiograms measurements, and blood sampling for lipid profile were conducted...
May 19, 2016: Annals of Noninvasive Electrocardiology
Jason G Andrade, Denis Roy, D George Wyse, Paul Dorian, Mario Talajic, Hugues Leduc, Julia Cadrin-Tourigny, Azadeh Shohoudi, Laurent Macle, Bernard Thibault, Peter G Guerra, Léna Rivard, Marc Dubuc, Paul Khairy
BACKGROUND: The association between standard parameters from a simple 12-lead ECG (i.e., QRS duration and PR, JT, and QT intervals) and adverse cardiovascular outcomes (cardiovascular mortality, all-cause mortality, arrhythmic mortality, and hospitalizations) in patients with a history of atrial fibrillation (AF) has not been previously studied. METHODS AND RESULTS: A pooled analysis of patient-level data was conducted on 5,436 patients, age 68.2 ± 8.3 years, 34...
April 2016: Journal of Cardiovascular Electrophysiology
Peyman Tabatabaei, Ala Keikhavani, Majid Haghjoo, Amirfarjam Fazelifar, Zahra Emkanjoo, Mahbobeh Zeighami, Hooman Bakhshandeh, Behshid Ghadrdoost, Abolfath Alizadeh
BACKGROUND: Prolongation of the QT interval is considered a risk factor for cardiac adverse events and mortality. Left bundle branch block (LBBB) lengthens the QT interval. The corrected QT interval (QTc) is most likely overestimated because its prolongation is caused by increases in depolarization duration and not in repolarization. OBJECTIVES: In this study, we aimed to apply corrected JT interval (JTc) as an appropriate measure of ventricular repolarization for predicting QTc in a formula...
May 2016: Research in Cardiovascular Medicine
Kristina Rücklová, Karel Koubský, Viktor Tomek, Peter Kubuš, Jan Janoušek
BACKGROUND: Prolonged corrected QT (QTc) intervals are frequently observed in children before atrial septal defect (ASD) closure in our department. OBJECTIVE: The aim of the study was to assess the effect of long-term right ventricular volume overload on repolarization. METHODS: QRS, QT, and JT intervals were measured manually in leads II and V5 of a standard 12-lead electrocardiogram in 45 children with an isolated ASD a day before and at least 6 months after ASD closure...
June 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Farzane Abdollahi, Siyavash Joukar, Hamid Najafipour, Abdolah Karimi, Yaser Masumi, Fateme Binayi
Anabolic steroids used to improve muscular strength and performance in athletics. Its long-term consumption may induce cardiovascular adverse effects. We assessed the risk of ventricular arrhythmias in rats which subjected to chronic nandrolone plus high-intensity endurance exercise. Animals were grouped as; control (CTL), exercise (Ex): 8 weeks under exercise, vehicle group (Arach): received arachis oil, and Nan group: received nandrolone decanoate 5 mg/kg twice a week for 8 weeks, Arach+Ex group, and Nan+Ex...
January 2016: Steroids
Mari Merentie, Jukka A Lipponen, Marja Hedman, Antti Hedman, Juha Hartikainen, Jenni Huusko, Line Lottonen-Raikaslehto, Viktor Parviainen, Svetlana Laidinen, Pasi A Karjalainen, Seppo Ylä-Herttuala
Mouse models are extremely important in studying cardiac pathologies and related electrophysiology, but very few mouse ECG analysis programs are readily available. Therefore, a mouse ECG analysis algorithm was developed and validated. Surface ECG (lead II) was acquired during transthoracic echocardiography from C57Bl/6J mice under isoflurane anesthesia. The effect of aging was studied in young (2-3 months), middle-aged (14 months) and old (20-24 months) mice. The ECG changes associated with pharmacological interventions and common cardiac pathologies, that is, acute myocardial infarction (AMI) and progressive left ventricular hypertrophy (LVH), were studied...
December 2015: Physiological Reports
Albin Behaghel, Anne Brunet-Bernard, Emmanuel Oger, Raphaël Martins, Erwan Donal, Maxime Fournet, Damien Feneon, Christophe Leclercq, Philippe Mabo, Claude Daubert
BACKGROUND: The relationship between electrical and mechanical indices of cardiac dyssynchronization in systolic heart failure (HF) remains poorly understood. OBJECTIVES: We examined retrospectively this relationship by using the daily practice tools in cardiology in recipients of cardiac resynchronization therapy (CRT) systems. METHODS: We studied 119 consecutive patients in sinus rhythm and QRS ≥ 120 ms (mean: 160 ± 17 ms) undergoing CRT device implantation...
December 2015: Archives of Cardiovascular Diseases
Maurizio Iacobone, Bruno Carnaille, F Fausto Palazzo, Menno Vriens
BACKGROUND: Hereditary hyperparathyroidism has been reported to occur in 5-10 % of cases of primary hyperparathyroidism in the context of multiple endocrine neoplasia (MEN) types 1, 2A and 4; hyperparathyroidism-jaw tumour (HPT-JT); familial isolated hyperparathyroidism (FIHPT); familial hypocalciuric hypercalcaemia (FHH); neonatal severe hyperparathyroidism (NSHPT) and autosomal dominant moderate hyperparathyroidism (ADMH). This paper aims to review the controversies in the main genetic, clinical and pathological features and surgical management of hereditary hyperparathyroidism...
December 2015: Langenbeck's Archives of Surgery
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