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Current Research in Neurology

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https://www.readbyqxmd.com/read/28214540/cognitive-performance-of-male-and-female-c57bl-6j-mice-after-repetitive-concussive-brain-injuries
#1
Alexander G Velosky, Laura B Tucker, Amanda H Fu, Jiong Liu, Joseph T McCabe
In contact sports, repetitive concussive brain injury (rCBI) is the prevalent form of head injury seen in athletes. The need for effective treatment is urgent as rCBI has been associated with a host of cognitive, behavioral and neurological complaints. There has been a growing trend in the use of female animals in pre-clinical research, but few studies have investigated possible sex differences following rCBI. The goal of the current study was to determine any differences between male and female C57BL/6J mice on assessments of learning and memory after repetitive concussive injury...
February 15, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28203060/acceptance-of-disease-and-lifestyle-modification-after-diagnosis-among-young-adults-with-epilepsy
#2
Anna Staniszewska, Urszula Religioni, Marta Dąbrowska-Bender
AIM: Assessment of factors affecting the degree of illness acceptance in patients with epilepsy and determination of whether the diagnosis of epilepsy influenced the functioning of this population group. MATERIALS AND METHODS: The Acceptance of Illness Scale (AIS) and authors' own questionnaire were used in this study. The study included 264 patients with epilepsy aged 20-40 years. The study was carried out during the period from June 2015 to June 2016. Participants were recruited through multiple channels, including online websites, a forum for people suffering from epilepsy, and from a neurological outpatient clinic in Warsaw...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28198092/the-burden-of-neurological-disease-in-the-united-states-a-summary-report-and-call-to-action
#3
EDITORIAL
Clifton L Gooch, Etienne Pracht, Amy R Borenstein
: The United States carries a substantial fiscal burden resulting from the nearly 100 million Americans with neurological disease. The combined annual costs of Alzheimer's and other dementias, low back pain, stroke, traumatic brain injury, migraine, epilepsy, multiple sclerosis, spinal cord injury and Parkinson's disease totals nearly 800 billion dollars and is rapidly rising due to the aging of the U.S. POPULATION: We provide a summary overview of the substantial current and future economic impact of neurological disease, and provide an action plan for reducing this burden through neurological research and enhanced clinical management of neurological disorders in the United States...
February 15, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28195514/blood-brain-barrier-on-a-chip-microphysiological-systems-that-capture-the-complexity-of-the-blood-central-nervous-system-interface
#4
Duc Tt Phan, R Hugh F Bender, Jillian W Andrejecsk, Agua Sobrino, Stephanie J Hachey, Steven C George, Christopher Cw Hughes
The blood-brain barrier is a dynamic and highly organized structure that strictly regulates the molecules allowed to cross the brain vasculature into the central nervous system. The blood-brain barrier pathology has been associated with a number of central nervous system diseases, including vascular malformations, stroke/vascular dementia, Alzheimer's disease, multiple sclerosis, and various neurological tumors including glioblastoma multiforme. There is a compelling need for representative models of this critical interface...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28194799/relative-analytical-sensitivity-of-donor-nucleic-acid-amplification-technology-screening-and-diagnostic-real-time-polymerase-chain-reaction-assays-for-detection-of-zika-virus-rna
#5
Mars Stone, Marion C Lanteri, Sonia Bakkour, Xutao Deng, Susan A Galel, Jeffrey M Linnen, Jorge L Muñoz-Jordán, Robert S Lanciotti, Maria Rios, Pierre Gallian, Didier Musso, José E Levi, Ester C Sabino, Lark L Coffey, Michael P Busch
BACKGROUND: Zika virus (ZIKV) has spread rapidly in the Pacific and throughout the Americas and is associated with severe congenital and adult neurologic outcomes. Nucleic acid amplification technology (NAT) assays were developed for diagnostic applications and for blood donor screening on high-throughput NAT systems. We distributed blinded panels to compare the analytical performance of blood screening relative to diagnostic NAT assays. STUDY DESIGN AND METHODS: A 25-member, coded panel (11 half-log dilutions of a 2013 French Polynesia ZIKV isolate and 2015 Brazilian donor plasma implicated in transfusion transmission, and 3 negative controls) was sent to 11 laboratories that performed 17 assays with 2 to 12 replicates per panel member...
February 14, 2017: Transfusion
https://www.readbyqxmd.com/read/28194640/life-beyond-a-diagnosis-of-glioblastoma-a-systematic-review-of-the-literature
#6
REVIEW
L Gately, S A McLachlan, A Dowling, J Philip
BACKGROUND: The median survival of glioblastoma is 12-14 months with less than 10% of patients surviving at least 2 years from diagnosis. Patients diagnosed with glioblastoma face poor prognosis, significant symptom burden, and high care needs. The aim of this study is to undertake a literature review to document the issues encountered by long-term survivors of glioblastoma, a small but important subset of patients. METHODS: MEDLINE, PsychInfo, and EMBASE were searched with core concepts: (1) glioblastoma, (2) survivor, and (3) terms pertaining to survivorship issues...
February 13, 2017: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/28186944/process-evaluations-in-neurological-rehabilitation-a-mixed-evidence-systematic-review-and-recommendations-for-future-research
#7
Patricia Masterson-Algar, Christopher R Burton, Jo Rycroft-Malone
OBJECTIVE: To systematically review how process evaluations are currently designed, what methodologies are used and how are they developed alongside or within neurological rehabilitation trials. METHODS: This mixed-methods systematic review had two evidence streams: stream I, studies reporting process evaluations alongside neurorehabilitation trials research and stream II, methodological guidance on process evaluation design and methodology. A search strategy was designed for each evidence stream...
November 8, 2016: BMJ Open
https://www.readbyqxmd.com/read/28183511/proposed-standardized-neurological-endpoints-for-cardiovascular-clinical-trials-an-academic-research-consortium-initiative
#8
REVIEW
Alexandra J Lansky, Steven R Messé, Adam M Brickman, Michael Dwyer, H Bart van der Worp, Ronald M Lazar, Cody G Pietras, Kevin J Abrams, Eugene McFadden, Nils H Petersen, Jeffrey Browndyke, Bernard Prendergast, Vivian G Ng, Donald E Cutlip, Samir Kapadia, Mitchell W Krucoff, Axel Linke, Claudia Scala Moy, Joachim Schofer, Gerrit-Anne van Es, Renu Virmani, Jeffrey Popma, Michael K Parides, Susheel Kodali, Michel Bilello, Robert Zivadinov, Joseph Akar, Karen L Furie, Daryl Gress, Szilard Voros, Jeffrey Moses, David Greer, John K Forrest, David Holmes, Arie P Kappetein, Michael Mack, Andreas Baumbach
Surgical and catheter-based cardiovascular procedures and adjunctive pharmacology have an inherent risk of neurological complications. The current diversity of neurological endpoint definitions and ascertainment methods in clinical trials has led to uncertainties in the neurological risk attributable to cardiovascular procedures and inconsistent evaluation of therapies intended to prevent or mitigate neurological injury. Benefit-risk assessment of such procedures should be on the basis of an evaluation of well-defined neurological outcomes that are ascertained with consistent methods and capture the full spectrum of neurovascular injury and its clinical effect...
February 14, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28161776/lncrnas-macromolecules-with-big-roles-in-neurobiology-and-neurological-diseases
#9
REVIEW
Ye Chen, Jun Zhou
Long noncoding RNAs (lncRNAs) are recently defined as thousands of RNA molecules longer than 200 nucleotides and lacking an appreciable open reading frame in mammals. Although lncRNAs lack protein-coding function, they play critical roles in the regulation of almost all the protein-coding genes in a cell at various stages including chromatin modification, transcription and post-transcriptional processing. It is thus not surprising that lncRNAs may be the crucial regulators in the normal development, physiology and pathology...
February 4, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28141971/paracrine-maturation-and-migration-of-sh-sy5y-cells-by-dental-pulp-stem-cells
#10
P Gervois, E Wolfs, Y Dillen, P Hilkens, J Ratajczak, R B Driesen, T Vangansewinkel, A Bronckaers, B Brône, T Struys, I Lambrichts
Neurological disorders are characterized by neurodegeneration and/or loss of neuronal function, which cannot be adequately repaired by the host. Therefore, there is need for novel treatment options such as cell-based therapies that aim to salvage or reconstitute the lost tissue or that stimulate host repair. The present study aimed to evaluate the paracrine effects of human dental pulp stem cells (hDPSCs) on the migration and neural maturation of human SH-SY5Y neuroblastoma cells. The hDPSC secretome had a significant chemoattractive effect on SH-SY5Y cells as shown by a transwell assay...
January 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28120010/thirty-years-of-transcranial-magnetic-stimulation-where-do-we-stand
#11
REVIEW
Ulf Ziemann
Transcranial magnetic stimulation (TMS) has been first described 30 years ago, and since then has gained enormous attention by neurologists, psychiatrists, neurosurgeons, clinical neurophysiologists, psychologists, and neuroscientist alike. In the early days, it was primarily used to test integrity of the corticospinal tract. Beyond further developments of TMS in diagnostics, mapping and monitoring of the motor system, major other applications expanded into using TMS as research tool in the cognitive neurosciences, and as therapeutic tool in neurological and psychiatric disease by virtue of inducing long-term change in excitability and connectivity of the stimulated brain networks...
January 25, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28108176/differential-housing-and-novelty-response-protection-and-risk-from-locomotor-sensitization
#12
Erik J Garcia, Tara N Haddon, Donald A Saucier, Mary E Cain
: High novelty seeking increases the risk for drug experimentation and locomotor sensitization. Locomotor sensitization to psychostimulants is thought to reflect neurological adaptations that promote the transition to compulsive drug taking. Rats reared in enrichment (EC) show less locomotor sensitization when compared to rats reared in isolation (IC) or standard conditions (SC). The current research study was designed to test if novelty response contributed locomotor sensitization and more importantly, if the different housing environments could change the novelty response to protect against the development of locomotor sensitization in both adolescence and adulthood...
January 17, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28105952/movement-visualisation-in-virtual-reality-rehabilitation-of-the-lower-limb-a-systematic-review
#13
REVIEW
Luara Ferreira Dos Santos, Oliver Christ, Kedar Mate, Henning Schmidt, Jörg Krüger, Christian Dohle
BACKGROUND: Virtual reality (VR) based applications play an increasing role in motor rehabilitation. They provide an interactive and individualized environment in addition to increased motivation during motor tasks as well as facilitating motor learning through multimodal sensory information. Several previous studies have shown positive effect of VR-based treatments for lower extremity motor rehabilitation in neurological conditions, but the characteristics of these VR applications have not been systematically investigated...
December 19, 2016: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28093982/pde7-selective-and-dual-inhibitors-advances-in-chemical-and-biological-research
#14
Agnieszka Jankowska, Artur Świerczek, Grażyna Chłoń-Rzepa, Maciej Pawłowski, Elżbieta Wyska
Phosphodiesterase 7 (PDE7) is an intracellular enzyme that specifically hydrolyses the second messenger, cyclic-3',5'-adenosine monophosphate (cAMP), into inactive non-cyclic nucleotide, 5'-AMP. To date, many structurally diverse compounds with PDE7 inhibitory properties have been described, including selective PDE7 inhibitors, dual PDE4/PDE7, PDE7/PDE8, and PDE7/GSK-3 inhibitors, and non-selective PDE inhibitors with high affinity for PDE7. Inhibitors of PDE7 provided beneficial effects in animal models of inflammatory and neurological disorders, including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and many others...
16, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28087243/using-deep-learning-to-investigate-the-neuroimaging-correlates-of-psychiatric-and-neurological-disorders-methods-and-applications
#15
REVIEW
Sandra Vieira, Walter H L Pinaya, Andrea Mechelli
Deep learning (DL) is a family of machine learning methods that has gained considerable attention in the scientific community, breaking benchmark records in areas such as speech and visual recognition. DL differs from conventional machine learning methods by virtue of its ability to learn the optimal representation from the raw data through consecutive nonlinear transformations, achieving increasingly higher levels of abstraction and complexity. Given its ability to detect abstract and complex patterns, DL has been applied in neuroimaging studies of psychiatric and neurological disorders, which are characterised by subtle and diffuse alterations...
January 10, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28074545/development-and-testing-of-a-database-of-nih-research-funding-of-aapm-members-a-report-from-aapm-working-group-for-the-development-of-a-research-database-wgdrd
#16
Brendan Whelan, Eduardo Moros, Rebecca Fahrig, James Deye, Thomas Yi, Michael Woodward, Paul Keall, Jeff Siewerdsen
PURPOSE: To produce and maintain a database of National Institutes of Health (NIH) funding of American Association of Physicists in Medicine (AAPM) members, to perform a top level analysis of this data, and to make this data (hereafter referred to as the AAPM research database) available for the use of the AAPM and its members. METHODS: NIH funded research dating back to 1985 is available for public download through the NIH exporter website, and AAPM membership information dating back to 2002 was supplied by the AAPM...
January 11, 2017: Medical Physics
https://www.readbyqxmd.com/read/28070115/proposal-for-a-prospective-registry-for-moyamoya-disease-in-japan
#17
Ken Kazumata, Masaki Ito, Haruto Uchino, Hiroshi Nishihara, Kiyohiro Houkin
The number of clinical research papers published worldwide on moyamoya disease (MMD) has increased recently. However, the majority of the literature comprises retrospective single-center studies collecting data on small numbers of patients. Several multi-center studies are ongoing in Japan; however, the current data are insufficient for comprehensively outlining the various characteristics of MMD. To enhance our knowledge on epidemiologic, vascular, and genetic aspects of MMD, a prospective multicenter registry will be established in Japan that will help to streamline clinical research as well as improve clinical treatments and long-term outcomes...
January 6, 2017: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/28065388/a-systematic-review-of-cognitive-function-and-psychosocial-well-being-in-school-age-children-with-narcolepsy
#18
REVIEW
Jane E Blackwell, Hetaf A Alammar, Anna R Weighall, Ian Kellar, Hannah M Nash
In August 2010, concerns were raised about an increase in the incidence rate of narcolepsy diagnosis in children and adolescents. Narcolepsy is a chronic neurological sleep disorder characterised by excessive daytime sleepiness and attacks of muscle weakness which are often precipitated by strong emotions, known as cataplexy. We systematically examined and updated the scientific literature on the consequences of narcolepsy on cognitive function and psychosocial well-being in school-age children. Eight studies published between 2005 and 2015 were eligible for inclusion in this review...
July 18, 2016: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/28055126/neuromodulation-therapies-for-alcohol-addiction-a-literature-review
#19
REVIEW
Celeste A Azevedo, Antonios Mammis
OBJECTIVES: The goal of this review is to explore alternative neurological therapies in the treatment of alcohol use disorder; including transcranial direct current stimulation (tDCS), transcranial magnetic stimulation, deep brain stimulation (DBS), electroconvulsive therapy (ECT), and the off-label use of the GABAB receptor agonist baclofen. METHODS: A comprehensive literature search was conducted through EBSCOhost regarding the neurological therapies in the treatment of alcoholism discussed in this paper...
January 5, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28035841/rehabilitation-robotics-for-the-upper-extremity-review-with-new-directions-for-orthopaedic-disorders
#20
Renée M Hakim, Brandon G Tunis, Michael D Ross
The focus of research using technological innovations such as robotic devices has been on interventions to improve upper extremity function in neurologic populations, particularly patients with stroke. There is a growing body of evidence describing rehabilitation programs using various types of supportive/assistive and/or resistive robotic and virtual reality-enhanced devices to improve outcomes for patients with neurologic disorders. The most promising approaches are task-oriented, based on current concepts of motor control/learning and practice-induced neuroplasticity...
December 30, 2016: Disability and Rehabilitation. Assistive Technology
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