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https://www.readbyqxmd.com/read/28540977/oral-contraceptive-pill-progestogen-or-oestrogen-pretreatment-for-ovarian-stimulation-protocols-for-women-undergoing-assisted-reproductive-techniques
#1
REVIEW
Cindy Farquhar, Luk Rombauts, Jan Am Kremer, Anne Lethaby, Reuben Olugbenga Ayeleke
BACKGROUND: Among subfertile women undergoing assisted reproductive technology (ART), hormone pills given before ovarian stimulation may improve outcomes. OBJECTIVES: To determine whether pretreatment with the combined oral contraceptive pill (COCP) or with a progestogen or oestrogen alone in ovarian stimulation protocols affects outcomes in subfertile couples undergoing ART. SEARCH METHODS: We searched the following databases from inception to January 2017: Cochrane Gynaecology and Fertility Group Specialised Register, The Cochrane Central Register Studies Online, MEDLINE, Embase, CINAHL and PsycINFO...
May 25, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28536663/endometriosis-nodule-causing-spontaneous-haemoperitoneum-in-pregnancy-a-case-report-and-literature-review
#2
Junaid Rafi, Geetha Mahindrakar, Debjani Mukhopadhyay
Spontaneous haemoperitoneum in pregnancy (SHiP) due to endometriosis is a very rare condition and this is a case of a 41-year-old primigravida, who presented at 32 weeks with sudden onset of severe lower abdominal pain without any uterine activity. This was a dichorionic-diamniotic twin pregnancy, following in vitro fertilisation for subfertility secondary to severe endometriosis. On admission, pain score was eight, with ten being the maximum of the scale. The vital signs were stable. Abdominal palpation revealed generalised tenderness with no guarding or palpable contraction...
2017: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28534597/metabolomics-for-improving-pregnancy-outcomes-in-women-undergoing-assisted-reproductive-technologies
#3
REVIEW
Charalampos S Siristatidis, Eleni Sertedaki, Dennis Vaidakis
BACKGROUND: In order to overcome the low effectiveness of assisted reproductive technologies (ART) and the high incidence of multiple births, metabolomics is proposed as a non-invasive method to assess oocyte quality, embryo viability, and endometrial receptivity, and facilitate a targeted subfertility treatment. OBJECTIVES: To evaluate the effectiveness and safety of metabolomic assessment of oocyte quality, embryo viability, and endometrial receptivity for improving live birth or ongoing pregnancy rates in women undergoing ART, compared to conventional methods of assessment...
May 23, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28530327/-clinical-aspects-of-intrauterine-insemination
#4
REVIEW
Eliezer Girsh, Semion Meltzer, Buzhena Saar-Ryss, Gad Liberty, Jaakov Rabinson, Shevach Friedler
Intrauterine insemination (IUI) is an intervention performed frequently in the treatment of couples suffering from subfertility and women treated using donor sperm. The factors predicting its success include female parameters such as age and ovarian function and male parameters such as sperm quality. However, many details regarding its clinical application such as the methodology of sperm preparation, timing of IUI, the number of inseminations in the same cycle, the recommended number of cycles to be performed and the minimal threshold values of the sperm sample profile required are controversial...
August 2016: Harefuah
https://www.readbyqxmd.com/read/28527569/estrogen-hormone-biology
#5
Katherine J Hamilton, Sylvia C Hewitt, Yukitomo Arao, Kenneth S Korach
The hormone estrogen is involved in both female and male reproduction, as well as numerous other biological systems including the neuroendocrine, vascular, skeletal, and immune systems. Therefore, it is also implicated in many different diseases and conditions such as infertility, obesity, osteoporosis, endometriosis, and a variety of cancers. Estrogen works through its two distinct nuclear receptors, estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ). Various transcriptional regulation mechanisms have been identified as the mode of action for estrogen, mainly the classical mechanism with direct DNA binding but also a nongenomic mode of action and one using tethered or indirect binding...
2017: Current Topics in Developmental Biology
https://www.readbyqxmd.com/read/28521575/high-frequency-of-de-novo-daz-microdeletion-in-sperm-nuclei-of-subfertile-men-possible-involvement-of-genome-instability-in-idiopathic-male-infertility
#6
Hossein Mozdarani, Pegah Ghoraeian, Sohail Mozdarani, Parvin Fallahi, Anahita Mohseni-Meybodi
The occurrence and diagnosis of Y-chromosome microdeletions, specifically deletions of the DAZ (Deleted in Azoospermia) genes are an important issue in male infertility. Screening Y chromosome microdeletion is mainly done using polymerase chain reaction (PCR) on blood leukocytes. However, there is some evidence indicating that presence of DAZ in somatic cells might not be indicative of its presence in the germ cell lineage. Therefore, a total of 130 men with poor semen quality were examined for presence of DAZ microdeletion in their leukocytes...
May 19, 2017: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28508691/corifollitropin-alfa-compared-with-follitropin-beta-in-gnrh-antagonist-ovarian-stimulation-protocols-in-an-unselected-population-undergoing-ivf-icsi
#7
Charalampos Siristatidis, Konstantinos Dafopoulos, Nikolas Christoforidis, George Anifandis, Vasileios Pergialiotis, Nikolaos Papantoniou
Recombinant DNA technologies have produced Corifollitropin alfa (CFa) used during IVF/ICSI in order to keep the circulating FSH levels above the threshold necessary to support multi-follicular growth for a week. In this prospective case-control study, we compared 70 participants treated with 150 μg CFa combined with 150 IU of follitropin beta (study group) with 70 subfertile participants with matching baseline characteristics, conforming with the same inclusion criteria and treated with an antagonist protocol using follitropin beta (control group)...
May 16, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28505939/re-influence-of-increasing-body-mass-index-on-semen-and-reproductive-hormonal-parameters-in-a-multi-institutional-cohort-of-subfertile-men
#8
Craig Niederberger
No abstract text is available yet for this article.
June 2017: Journal of Urology
https://www.readbyqxmd.com/read/28501361/intrauterine-insemination-with-gonadotropin-stimulation-or-in%C3%A2-vitro-fertilization-for-the-treatment-of-unexplained-subfertility-a-randomized-controlled-trial
#9
Anupa Nandi, Priya Bhide, Richard Hooper, Anil Gudi, Amit Shah, Khalid Khan, Roy Homburg
OBJECTIVE: To evaluate the best first line management option for the treatment of unexplained subfertility-controlled ovarian hyperstimulation (COH) with gonadotropins and IUI or IVF. DESIGN: Randomized controlled trial. SETTING: Single center trial in a tertiary referral unit. PATIENT(S): Couples with unexplained subfertility. INTERVENTION(S): Couples were randomized to receive either three cycles of IUI + COH or one cycle of IVF...
May 10, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28497913/role-of-antioxidants-in-assisted-reproductive-techniques
#10
REVIEW
Ashok Agarwal, Ahmad Majzoub
Oxidative stress (OS) has been recognized as a significant cause of suboptimal assisted reproductive outcome. Many of the sperm preparation and manipulation procedures that are necessary in the in vitro environment can result in excessive production of reactive oxygen species (ROS) thereby exposing the gametes and growing embryos to significant oxidative damage. Antioxidants have long been utilized in the management of male subfertility as they can counterbalance the elevated levels of ROS inducing a high state of OS...
April 30, 2017: World Journal of Men's Health
https://www.readbyqxmd.com/read/28483662/the-management-of-polyps-in-female-reproductive-organs
#11
REVIEW
Vasilios Tanos, Kelsey Elizabeth Berry, Jaana Seikkula, Elissa Abi Raad, Andreas Stavroulis, Zaki Sleiman, Rudi Campo, Stephan Gordts
Polyps of the lower reproductive tract are found in 7.8-50% of women. It has been hypothesized that cytogenetic modifications on chromosomes 6, 7 and 12 as well as epigenetic factors involving enzyme and metabolic activities may cause polyps to develop. Cervical polyps found in 2-5% of cases are of low clinical significance and can cause, although rarely, post coital bleedings. Cervical polyps grow during pregnancy and mucorrhoea. Trans vaginal ultrasound (TVU) provides an excellent diagnostic technique to diagnose the size and the anatomic location of endometrial polyps (EPs)...
May 5, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28481181/a-diabetic-pregnancy-alters-the-expression-of-stress-related-receptors-in-gastrulating-rabbit-blastocyst-and-in-the-reproductive-tract
#12
Tom Seeling, Štefan Čikoš, Katarzyna J Grybel, Žofia Janštová, S Mareike Pendzialek, Maria Schindler, Alexandra Špirková, Anne Navarrete Santos
The incidence of diabetes mellitus for young people rises since years. A preconceptional diabetes mellitus leads to subfertility. Most of the causes for a diabetic subfertility are still unknown. Stress can significantly deteriorate glycemic control in diabetes. Several mechanisms by which "stress hormones", like adrenaline and cortisol or corticosterone, can contribute to the regulation of glucose homeostasis have been identified. Using reverse transcription-polymerase chain reaction (RT-PCR) and quantitative real-time RT-PCR, we examined the expression of adrenergic receptors and the glucocorticoid receptor transcripts in the female rabbit reproductive tract and in gastrulating blastocysts developed in normoinsulinemic mothers and in mothers with experimentally induced diabetes mellitus type 1...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28475264/rfamide-related-peptide-3-and-gonadotropin-releasing-hormone-ii-are-autocrine-paracrine-regulators-of-testicular-function-in-the-boar
#13
REVIEW
Clay A Lents, Jennifer F Thorson, Amy T Desaulniers, Brett R White
Widespread use of artificial insemination in swine requires millions of doses of boar semen each year. Subfertility of boars remains a major constraint, which can impact the reproductive efficiency of thousands of sows, so a better understanding of testicular function is needed in order to develop methods to improve semen production. With this in mind, the effects of RFamide-related peptide 3 (RFRP3) and gonadotropin-releasing hormone-II (GnRH-II) on gonadotropin secretion and testicular function of pigs are reviewed here...
May 5, 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/28472862/three-dimensional-saline-infusion-sonography-compared-to-two-dimensional-saline-infusion-sonography-for-the-diagnosis-of-focal-intracavitary-lesions
#14
REVIEW
Lotte L Nieuwenhuis, Frederik Jr Hermans, A J Marjolein Bij de Vaate, Mariska Mg Leeflang, Hans Am Brölmann, Wouter Jk Hehenkamp, Ben Willem J Mol, T Justin Clark, Judith Af Huirne
BACKGROUND: Focal abnormalities most commonly acquired within the uterine cavity include endometrial polyps (arising from the endometrium) and submucous fibroids (arising from the myometrium). These benign abnormalities can cause several problems, including abnormal uterine bleeding (AUB) and subfertility. Two-dimensional saline infusion sonography (2D SIS) is a minimally invasive test that can be used to diagnose these pathologies, but it is less accurate than hysteroscopy, which is a more invasive procedure by which an endoscope allows direct visualisation of the uterine cavity...
May 5, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28472455/the-long-term-prognosis-for-live-birth-in-couples-initiating-fertility-treatments
#15
S S Malchau, A A Henningsen, A Loft, S Rasmussen, J Forman, A Nyboe Andersen, A Pinborg
STUDY QUESTION: What are the long-term chances of having a child for couples starting fertility treatments and how many conceive with ART, IUI and without treatment? SUMMARY ANSWER: Total 5-year live birthrates were strongly influenced by female age and ranged from 80% in women under 35-26% in women ≥40 years, overall, 14% of couples conceived naturally and one-third of couples starting treatments with intrauterine insemination delivered from that treatment. WHAT IS KNOWN ALREADY: Few studies report success rates in fertility treatments across a couple's complete fertility treatment history, across clinics, evaluating live births after insemination, ART and natural conceptions...
May 4, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28463030/use-of-cyproterone-acetate-ethinylestradiol-in-polycystic-ovary-syndrome-rationale-and-practical-aspects
#16
X Ruan, A Kubba, A Aguilar, A O Mueck
INTRODUCTION: Polycystic ovary syndrome (PCOS) is a common, heterogeneous disorder characterised by hyperandrogenic skin symptoms, irregular menstruation and subfertility, increased risk of endometrial malignancy, and increased risk of preventable diseases associated with metabolic syndrome. Cyproterone acetate (CPA) 2 mg, combined with ethinylestradiol (EE) 35 μg, is indicated for the treatment of moderate to severe acne related to androgen-sensitivity (with or without seborrhea) and/or hirsutism, in women of reproductive age...
May 2, 2017: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/28460579/management-of-weight-loss-in-obesity-associated-male-infertility-a-spotlight-on-bariatric-surgery
#17
Firass Abiad, Johnny Awwad, Hussein A Abbas, Dina Zebian, Ghina Ghazeeri
In recent years, there has been a paralleled increase between male obesity and infertility rates. Obesity is associated with impaired hypothalamic-pituitary-gonadal axis, aberrant semen parameters, and subfertility or infertility. Weight loss is strongly recommended for the management of obesity-associated infertility. Lifestyle modifications that include caloric restriction and increased physical activity have a short-lived impact. Bariatric surgery is a better and more durable weight loss alternative. Comprehensive information about the benefits of weight loss on obesity-associated male infertility following bariatric surgery is still emerging...
May 2, 2017: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28456148/impact-of-emotional-disorders-on-semen-quality-in-men-treated-for-infertility
#18
Artur Wdowiak, Agnieszka Bień, Grażyna Iwanowicz-Palus, Marta Makara-Studzińska, Iwona Bojar
OBJECTIVE: Semen quality depends on factors such as lifestyle, environment, and hormone secretion. OBJECTIVE: The purpose of the study was to assess the correlation between emotional disorders and the secretion of selected hormones, and to assess the impact of these disorders on semen quality. METHODS: The study covered 60 fertile and 112 subfertile males. The sperm was obtained by masturbation, and examined directly after liquidation according to the 2010 criteria of the World Health Organization...
February 15, 2017: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/28455086/adverse-pregnancy-birth-and-infant-outcomes-in-twins-effects-of%C3%A2-maternal-fertility-status-and-infant-gender-combinations-the-massachusetts-outcomes-study-of-assisted-reproductive-technology
#19
Barbara Luke, Daksha Gopal, Howard Cabral, Judy E Stern, Hafsatou Diop
BACKGROUND: It is unknown whether the risk of adverse outcomes in twin pregnancies among subfertile women, conceived with and without in vitro fertilization, differs from those conceived spontaneously. OBJECTIVE: We sought to evaluate the effects of fertility status on adverse perinatal outcomes in twin pregnancies on a population basis. STUDY DESIGN: All twin live births of ≥22 weeks' gestation and ≥350 g birthweight to Massachusetts resident women in 2004 through 2010 were linked to hospital discharge records, vital records, and in vitro fertilization cycles...
April 25, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28454805/managing-subfertility-in-patients-with-heart-disease-what-are-the-choices
#20
REVIEW
Matthew Cauldwell, Roshni R Patel, Philip J Steer, Lorna Swan, Julian Norman-Taylor, Michael Gatzoulis, Mark R Johnson
More women with heart disease are reaching reproductive age and will want to embark upon pregnancy. Furthermore, many of these women are delaying pregnancy until later in life when they may be exposed to a greater number of complications from their heart disease. A relatively high proportion of these women will pursue fertility treatment to achieve a pregnancy; consequently, the management of subfertile couples where the woman (or man) has heart disease is of growing importance. In this review, we discuss how fertility investigations and treatment can impact a women with heart disease and how some of the potential complications can be minimized or avoided...
May 2017: American Heart Journal
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