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https://www.readbyqxmd.com/read/29785531/prevalent-genotypes-of-methylenetetrahydrofolate-reductase-mthfr-in-recurrent-miscarriage-and-recurrent-implantation-failure
#1
Yuanchang Zhu, Tonghua Wu, Lijun Ye, Guangui Li, Yong Zeng, Yaou Zhang
OBJECTIVE: To evaluate the association of two common methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms with recurrent miscarriage (RM) and repeated implantation failure (RIF) METHODS: The study comprised of 521 patients, with a history of RM (n = 370) or RIF (n = 151). One hundred forty-four women with fallopian tube blockages who had successfully conceived after the first in vitro fertilization embryo transfer treatment served as the control group. The MTHFR alleles, genotypes, and haplotypes were assessed in different groups...
May 21, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29780815/endometriosis-malignant-transformation-epigenetics-as-a-probable-mechanism-in-ovarian-tumorigenesis
#2
REVIEW
Jiaxing He, Weiqin Chang, Chunyang Feng, Manhua Cui, Tianmin Xu
Endometriosis, defined as the presence of ectopic endometrial glands and stroma outside the uterine cavity, is a chronic, hormone-dependent gynecologic disease affecting millions of women across the world, with symptoms including chronic pelvic pain, dysmenorrhea, dyspareunia, dysuria, and subfertility. In addition, there is well-established evidence that, although endometriosis is considered benign, it is associated with an increased risk of malignant transformation, with the involvement of various mechanisms of development...
2018: International Journal of Genomics
https://www.readbyqxmd.com/read/29777489/serum-antibody-response-to-chlamydia-trachomatis-troa-and-htra-in-women-with-tubal-factor-infertility
#3
T Rantsi, P Joki-Korpela, K Hokynar, I Kalliala, H Öhman, H-M Surcel, J Paavonen, A Tiitinen, M Puolakkainen
Persistent genital chlamydial infection may lead to tubal factor infertility (TFI). Chlamydia trachomatis TroA and HtrA are proteins expressed during persistent chlamydial infection in vitro. We studied serum IgG antibody response against these proteins by EIA in women with TFI and in subfertile women without tubal pathology. Altogether, 22 of 258 subfertile women (8.5%) had TFI which was unilateral in 17 cases and bilateral in 5 cases. Overall, 55 (21.3%) of the 258 women had TroA and 39 (15.1%) had HtrA antibodies...
May 18, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29774489/the-role-of-lifestyle-in-male-infertility-diet-physical-activity-and-body-habitus
#4
REVIEW
Russell P Hayden, Ryan Flannigan, Peter N Schlegel
PURPOSE OF REVIEW: Increasing attention to primary and secondary prevention of male infertility through modifiable lifestyle factors has gained traction amongst both patients and infertility specialists. In this review, the available evidence of modifiable lifestyle choices, specifically diet, physical activity, and body habitus, are evaluated. RECENT FINDINGS: Studies examining diet, exercise/physical activity, and body habitus are characterized by conflicting conclusions, difficult confounders, and imperfect end points to judge male reproductive potential...
May 17, 2018: Current Urology Reports
https://www.readbyqxmd.com/read/29768247/oocyte-triggering-day-progesterone-levels-and-endometrial-appearance-in-normoresponders-undergoing-ivf-icsi-cycles-a-hypothesis-and-a-study-protocol
#5
Charalampos Siristatidis, Panagiotis Drakopoulos, Paraskevi Vogiatzi, Vasilios Karageorgiou, George Daskalakis
In this report, we propose a study protocol capable of improving IVF outcomes in subfertile women with expected normal ovarian response. This proposal derives from conflicting published data and observations in our daily practice, concerning the negative impact of progesterone (P4) elevation at the day of oocyte triggering on pregnancy outcomes. Our hypothesis points to the combination of two previous "suspects" of reduced success after assisted reproduction techniques (ART) - the endometrium ultrasonographic parameters and P4 elevation at the day of oocyte triggering on their impact on pregnancy outcomes...
May 16, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/29767691/thyroid-hormones-and-female-reproduction
#6
Juneo F Silva, Natália M Ocarino, Rogéria Serakides
Thyroid hormones are vital for the proper functioning of the female reproductive system, since they modulate the metabolism and development of ovarian, uterine and placental tissues. Therefore, hypo- and hyperthyroidism may result in subfertility or infertility in both women and animals. Other well-documented sequelae of maternal thyroid dysfunctions include menstrual/estral irregularity, anovulation, abortion, preterm delivery, preeclampsia, intrauterine growth restriction, postpartum thyroiditis, and mental retardation in children...
May 14, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29751649/serosurvey-for-infectious-agents-associated-with-subfertility-and-abortion-in-dairy-cattle-in-trinidad-and-tobago-west-indies
#7
Michael J Morris, Jamie Sookhoo, Lemar Blake, Arianne Brown Jordan, Justine John, Sheliza Ali, Gervaise Sarjusingh, Janelle St Aime, Edward H Amoroso, Christopher A L Oura
Despite frequent reports of subfertility and abortion in dairy cattle in Trinidad and Tobago (T&T), little is known about the potential infectious and non-infectious causes. This study set out to investigate possible infectious causes of reproductive problems by measuring the seroprevalence of four of the most significant reproductive pathogens in dairy cattle worldwide: Brucella abortus (B. abortus) ; Neospora caninum ( N. caninum ), Bovine Viral Diarrhoea virus (BVDV), and Infectious Bovine Rhinotracheitis virus (IBRV)...
May 11, 2018: Veterinary Sciences
https://www.readbyqxmd.com/read/29744644/an-epigenetic-association-of-malformations-adverse-reproductive-outcomes-and-fetal-origins
#8
Mark Lubinsky
VACTERL, the prototype for associated congenital anomalies, also has connections with functional issues such as pregnancy losses, prematurity, growth delays, perinatal difficulties, and parental subfertility. This segues into a broader association with similar connections even in the absence of malformations. DNA methylation disturbances in the ovum are a likely cause, with epigenetic links to individual components and to folate effects before conception, explaining diverse fetal and placental findings and providing a link to fetal origin hypothesis-related effects...
May 9, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29743106/the-foam-study-is-hysterosalpingo-foam-sonography-hyfosy-a-cost-effective-alternative-for-hysterosalpingography-hsg-in-assessing-tubal-patency-in-subfertile-women-study-protocol-for-a-randomized-controlled-trial
#9
Joukje van Rijswijk, Nienke van Welie, Kim Dreyer, Machiel H A van Hooff, Jan Peter de Bruin, Harold R Verhoeve, Femke Mol, Kimiko A Kleiman-Broeze, Maaike A F Traas, Guido J J M Muijsers, Arentje P Manger, Judith Gianotten, Cornelia H de Koning, Aafke M H Koning, Neriman Bayram, David P van der Ham, Francisca P J M Vrouenraets, Michaela Kalafusova, Bob I G van de Laar, Jeroen Kaijser, Miriam F van Oostwaard, Wouter J Meijer, Frank J M Broekmans, Olivier Valkenburg, Lucy F van der Voet, Jeroen van Disseldorp, Marieke J Lambers, Henrike E Peters, Marit C I Lier, Cornelis B Lambalk, Madelon van Wely, Patrick M M Bossuyt, Jaap Stoker, Fulco van der Veen, Ben W J Mol, Velja Mijatovic
BACKGROUND: Tubal pathology is a causative factor in 20% of subfertile couples. Traditionally, tubal testing during fertility work-up is performed by hysterosalpingography (HSG). Hysterosalpingo-foam sonography (HyFoSy) is a new technique that is thought to have comparable accuracy as HSG, while it is less expensive and more patient friendly. HyFoSy would be an acceptable alternative for HSG, provided it has similar effectiveness in terms of patient outcomes. METHODS/DESIGN: We aim to compare the effectiveness and costs of management guided by HyFoSy or by HSG...
May 9, 2018: BMC Women's Health
https://www.readbyqxmd.com/read/29740927/are-singleton-pregnancies-after-assisted-reproduction-technology-art-associated-with-a-higher-risk-of-placental-anomalies-compared-with-non-art-singleton-pregnancies-a-systematic-review-and-meta-analysis
#10
REVIEW
B G Vermey, A Buchanan, G M Chambers, E M Kolibianakis, J Bosdou, M G Chapman, C A Venetis
BACKGROUND: Placental anomalies (placenta praevia, placental abruption, morbidly adherent placenta and cord insertion anomalies) are associated with maternal and fetal morbidity and mortality. It has been suggested these might be more prevalent in pregnancies after assisted reproduction technology (ART). OBJECTIVES: To determine whether ART singleton pregnancies are associated with an increased risk of placental anomalies compared with non-ART singleton pregnancies...
May 8, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29733335/the-flagellar-protein-enkurin-is-required-for-mouse-sperm-motility-and-for-transport-through-the-female-reproductive-tract
#11
Melissa K Jungnickel, Keith A Sutton, Mark A Baker, Michael G Cohen, Michael J Sanderson, Harvey M Florman
Enkurin was identified initially in mouse sperm where it was suggested to act as an intracellular adaptor protein linking membrane calcium influx to intracellular signaling pathways. In order to examine the function of this protein a targeted mutation was introduced into the mouse Enkurin gene. Males that were homozygous for this mutated allele were subfertile. This was associated with lower rates of sperm transport in the female reproductive tract, including reduced entry into the oviduct and slower migration to the site of fertilization in the distal oviduct, and with poor progressive motility in vitro...
May 3, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29733332/ccdc87-is-critical-for-sperm-function-and-male-fertility
#12
Tongtong Wang, Qianqian Yin, Xuehao Ma, Ming-Han Tong, Yuchuan Zhou
Male infertility has become an increasingly common health concern in recent years. Apart from environmental factors, nutrition, lifestyle, and sexually transmitted diseases, genetic defects are important causes of male infertility. Many genes have been demonstrated to be associated with male infertility. However, the roles of some functional genes in infertility, especially those that are specifically expressed in the reproductive system, remain to be elucidated. Here, we demonstrated that the testis-specific gene coiled-coil domain-containing 87 (Ccdc87) is critical for male fertility...
May 3, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29732473/thermoregulatory-responses-and-reproductive-traits-in-composite-beef-bulls-raised-in-a-tropical-climate
#13
Narian Romanello, José de Brito Lourenço Junior, Waldomiro Barioni Junior, Felipe Zandonadi Brandão, Cintia Righetti Marcondes, José Ricardo Macedo Pezzopane, Messy Hannear de Andrade Pantoja, Daniela Botta, Alessandro Giro, Ana Beatriz Bossois Moura, Andréa do Nascimento Barreto, Alexandre Rossetto Garcia
It is believed that increased livestock production is limited by tropical climate. Thermal imbalance in bulls can lead to hyperthermia and alter testicular metabolism, causing subfertility or infertility. Therefore, the thermoregulation of composite Canchim bulls (5/8 Charolais × 3/8 Zebu) raised in tropical climate as well as their consequences in the physiological, hematological, hormonal, and andrological parameters were evaluated monthly. The bulls (n = 18; 30.0 ± 1.5 months; 503.8 ± 23...
May 7, 2018: International Journal of Biometeorology
https://www.readbyqxmd.com/read/29713550/role-of-varicocele-treatment-in-assisted-reproductive-technologies
#14
REVIEW
Mehmet G Sönmez, Ahmet H Haliloğlu
Objective: In this review, we investigate the advantage of varicocele repair prior to assisted reproductive technologies (ART) for infertile couples and provide cost analysis information. Materials and methods: We searched the following electronic databases: PubMed, Medline, Excerpta Medica Database (Embase), Cumulative Index to Nursing and Allied Health Literature (CINAHL). The following search strategy was modified for the various databases and search engines: 'varicocele', 'varicocelectomy', 'varicocele repair', 'ART', ' in vitro fertilisation (IVF)', 'intracytoplasmic sperm injection (ICSI)'...
March 2018: Arab Journal of Urology
https://www.readbyqxmd.com/read/29705270/nuclear-progestin-receptor-pgr-knockouts-resulted-in-subfertility-in-male-tilapia-oreochromis-niloticus
#15
Xuelian Fang, Limin Wu, Lanying Yang, Lingyun Song, Jing Cai, Feng Luo, Jing Wei, Linyan Zhou, Deshou Wang
It was documented that 17α, 20β-dihydroxy-4-pregnen-3-one (DHP), a fish specific progestin, might play critical roles in spermatogenesis, sperm maturation and spermiation partially through activating nuclear receptor (Pgr). However, no direct evidence is available to demonstrate the functions of DHP in fish spermatogenesis. To further elucidate the roles of DHP in teleosts, we generated a pgr homozygous mutant line in XY Nile tilapia (Oreochromis niloticus). Pgr gene mutation resulted in the development of a smaller, thinner testis and a lower GSI compared with normal testis...
April 26, 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29705068/sperm-chromatin-alterations-in-fertile-and-subfertile-bulls
#16
Elisson Terêncio Souza, Cláudio Vieira Silva, Bruno Augusto Nassif Travençolo, Benner Geraldo Alves, Marcelo Emílio Beletti
Alterations in sperm chromatin have been related with subfertility in several mammals. In this study, chromatin alteration types (Base, Basal half, Central axis, Dispersed, and Whole) were assessed by toluidine blue (TB) staining, 6-diamidino-2-fenilindole (DAPI) and anti-protamine 1 antibody (anti-PR1) labeling in sperm samples of fertile and subfertile bulls. Semen samples were obtained from bulls kept in Artificial Insemination Center (fertile bulls) or from bulls subjected to scrotal insulation (subfertile bulls)...
April 25, 2018: Reproductive Biology
https://www.readbyqxmd.com/read/29680465/treatment-strategies-and-cumulative-live-birth-rates-in-who-ii-ovulation-disorders
#17
Sanne C Braam, Jan Peter de Bruin, Erato T I A Buisman, Monique Brandes, Willianne L D M Nelen, Jesper M J Smeenk, Jan Willem van der Steeg, Ben Willem J Mol, Carl J C M Hamilton
OBJECTIVE: To assess the live birth rate in women with WHO II anovulation and the proportion of women that need second or third line treatments if the initial therapy fails. STUDY DESIGN: In this multicenter cohort study we included couples with unfulfilled child wish who were referred to three fertility clinics in the Netherlands and selected women with a WHO II ovulation disorder as the only final infertility diagnosis (n = 468). RESULTS: The cumulative live birth rate of the total group was 82% (383/468)...
April 10, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29680455/current-review-of-artificial-insemination-in-dogs
#18
REVIEW
Stuart J Mason
Artificial insemination is the collection of semen from the male and the subsequent insertion of the collected semen into the female. Artificial insemination may be requested for several reasons, including inability to achieve a mating or due to the use of fresh chilled or frozen semen. A good understanding of the cycle of the bitch is imperative for maximizing pregnancy rates, as poor timing of insemination is the most common cause of subfertility in the bitch. Insemination techniques commonly undertaken in the bitch include vaginal insemination, surgical intrauterine insemination, and transcervical insemination...
April 18, 2018: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/29678334/evaluation-of-canine-sperm-and-management-of-semen-disorders
#19
REVIEW
Kara A Kolster
Semen evaluation of the male dog is a critical step in any canine infertility work-up. Assessment of total sperm count, sperm viability, and sperm morphology are the mainstay of breeding soundness evaluation. Adjunct tests, such as ultrasonography and serum hormone levels, can aid in diagnosis. Pharmacologic treatments, dietary supplements, and management practices may help improve breeding success in subfertile dogs. This article discusses a clinically practical approach to assessing sperm abnormalities and fertility in male dogs...
April 17, 2018: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/29671528/testicular-cancer-diagnosis-and-treatment
#20
Drew C Baird, Garrett J Meyers, Jocelyn S Hu
Testicular cancer is the most common solid tumor among males 15 to 34 years of age, with an estimated 8,850 new cases and 410 deaths during 2017 in the United States. With effective treatment, the overall five-year survival rate is 97%. Risk factors for testicular cancer include undescended testis (cryptorchidism), personal or family history of testicular cancer, age, ethnicity, and infertility. The U.S. Preventive Services Task Force recommends against routine screening in asymptomatic men. Men with symptoms should receive a complete history and physical examination...
February 15, 2018: American Family Physician
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