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https://www.readbyqxmd.com/read/28210481/human-papillomavirus-hpv-virion-induced-cancer-and-subfertility-two-sides-of-the-same-coin
#1
REVIEW
T Depuydt, J Beert, E Bosmans, G Salembier
In the natural history of HPV infections, the HPV virions can induce two different pathways, namely the infec- tious virion producing pathway and the clonal transforming pathway. An overview is given of the burden that is associated with HPV infections that can both lead to cervical cancer and/or temporal subfertility. That HPV infections cause serious global health burden due to HPV-associated cancers is common knowledge, but that it is also responsible for a substantial part of idiopathic subfertility is greatly underestimated...
December 2016: Facts, Views & Vision in ObGyn
https://www.readbyqxmd.com/read/28205459/effects-of-an-antagonistic-analog-of-growth-hormone-releasing-hormone-on-endometriosis-in-a-mouse-model-and-in-vitro
#2
Frank Köster, Li Jin, Yuanming Shen, Andrew V Schally, Ren-Zhi Cai, Norman L Block, Daniela Hornung, Gabriele Marschner, Achim Rody, Jörg B Engel, Dominique Finas
Endometriosis is a benign gynecologic disorder causing dysmenorrhea, pelvic pain, and subfertility. Receptors for the growth hormone-releasing hormone (GHRH) were found in endometriotic tissues. Antagonists of GHRH have been used to inhibit the growth of endometriotic endometrial stromal cells. In this study, the GHRH receptor splice variant (SV) 1 was detected in human endometrial tissue samples by Western blots and quantitative reverse transcription polymerase chain reaction (qRT-PCR). The highest messenger RNA (mRNA) and protein levels of SV1 were found in eutopic endometrium from patients with endometriosis compared to ectopic endometriotic tissues and endometrium from normal patients...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28194755/withdrawn-exercise-for-dysmenorrhoea
#3
REVIEW
Julie Brown, Stephen Brown
BACKGROUND: Dysmenorrhoea is characterised by cramping lower abdominal pain that may radiate to the lower back and upper thighs and is commonly associated with nausea, headache, fatigue and diarrhoea. Physical exercise has been suggested as a non-medical approach to the management of these symptoms. OBJECTIVES: To assess the evidence for the effectiveness of exercise in the treatment of dysmenorrhoea. SEARCH METHODS: A search was conducted using the methodology of the Menstrual Disorders and Subfertility Group (August 2009)...
February 14, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28193732/error-prone-meiotic-division-and-subfertility-in-mice-with-oocyte-conditional-knockdown-of-pericentrin
#4
Claudia Baumann, Xiaotian Wang, Luhan Yang, Maria M Viveiros
Mouse oocytes lack canonical centrosomes and instead contain unique acentriolar microtubule-organizing centers (aMTOCs). To test the function of these distinct aMTOCs in meiotic spindle formation -Pericentrin (Pcnt), an essential centrosome/MTOC protein, was knocked down exclusively in oocytes using transgenic RNAi. Here we provide evidence that disruption of aMTOC function in oocytes promotes spindle instability and severe meiotic errors that lead to pronounced female subfertility. Pcnt-depleted oocytes from transgenic (Tg) mice are ovulated at metaphase-II, but show significant chromosome misalignment, aneuploidy and premature sister chromatid separation...
February 13, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28193304/physiological-response-and-semen-quality-of-rabbit-bucks-supplemented-with-moringa-leaves-ethanolic-extract-during-summer-season
#5
N I El-Desoky, N M Hashem, A Elkomy, Z R Abo-Elezz
Exposure of rabbit bucks to summer heat stress reduces their homeostasis and semen quality leading to a temporal subfertility. The potentiality of ethanolic extract of Moringa oleifera leaves (M. oleifera ethanolic extract (MLEE)) to reduce negative impacts of heat stress on physiological and semen quality traits was investigated. A total of 28 adult V-line rabbit bucks were randomly distributed among four experimental groups of seven rabbits each. The first group received water (placebo) and served as a control (M0)...
February 14, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28187518/male-caffeine-and-alcohol-intake-in-relation-to-semen-parameters-and-in%C3%A2-vitro-fertilization-outcomes-among-fertility-patients
#6
A E Karmon, T L Toth, Y-H Chiu, A J Gaskins, C Tanrikut, D L Wright, R Hauser, J E Chavarro
Much of the literature on the impact of male caffeine and alcohol intake on reproductive outcomes has utilized semen quality as a proxy for male fertility, although semen parameters have a limited predictive value for spontaneous pregnancy. The objective of this study was to investigate whether male caffeine and alcohol intakes are associated with semen parameters and assisted reproductive technology outcome. The Environment and Reproductive Health Study, an ongoing prospective cohort study, enrolls subfertile couples presenting for treatment at an academic fertility center (2007-2012)...
February 10, 2017: Andrology
https://www.readbyqxmd.com/read/28186620/an-update-on-the-diagnosis-surgical-management-and-fertility-outcomes-for-women-with-endometrioma
#7
Ryan Cranney, George Condous, Shannon Reid
Endometriosis is estimated to affect up to 50% of infertile women, and severity of endometriosis stage appears to correlate with reduced fertility. Ovarian endometrioma are found in up to 44% of women with endometriosis, and are significantly associated with the presence of pelvic deep infiltrating endometriosis, ovarian adhesions, and pouch of Douglas obliteration. Through the use of MEDLINE and PubMed databases, we conducted a literature review of all available research related to the diagnosis, surgical management and fertility outcomes for women with endometrioma...
February 10, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28185741/clearance-of-tritrichomonas-foetus-in-experimentally-infected-heifers-protected-with-vaccines-based-on-killed-t-foetus-with-different-adjuvants
#8
Lumila I Fuchs, Marcelo C Fort, Dora Cano, Carina M Bonetti, Hugo D Giménez, Pablo M Vázquez, Diana Bacigalupe, Javier D Breccia, Carlos M Campero, Jorge A Oyhenart
Tritrichomonas foetus is a flagellated protozoan that causes a sexually transmitted disease in cattle. Trichomonosis is characterized by early abortions, subfertility and a significant decrease in productivity. Vaccine preparations containing whole T. foetus can reduce the time of residence of the pathogen in the host cervix after experimental infection. Here, T. foetus vaccines prepared with different adjuvants were tested, in parallel with a commercial vaccine, for their efficacy to clear the infection. The median time for clearance of infection was 69days in non-immunized animals, 55days in animals treated with aluminum hydroxide, 41days with oil-in-water or saponin based vaccines or with a commercial vaccine and 27days in animals treated with saponin plus aluminum hydroxide...
February 6, 2017: Vaccine
https://www.readbyqxmd.com/read/28185073/natural-conception-rates-in-subfertile-couples-following-fertility-awareness-training
#9
P Frank-Herrmann, C Jacobs, E Jenetzky, C Gnoth, C Pyper, S Baur, G Freundl, M Goeckenjan, T Strowitzki
PURPOSE: To analyze cumulative pregnancy rates of subfertile couples after fertility awareness training. METHODS: A prospective observational cohort study followed 187 subfertile women, who had received training in self-observation of the fertile phase of the menstrual cycle with the Sensiplan method, for 8 months. The women, aged 21-47 years, had attempted to become pregnant for 3.5 years on average (range 1-8 years) before study entry. Amenorrhea, known tubal occlusion and severe male factor had been excluded...
February 9, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28166974/endometrial-mrna-expression-of-selected-pro-inflammatory-factors-and-mucins-in-repeat-breeder-cows-with-and-without-subclinical-endometritis
#10
K Wagener, H Pothmann, I Prunner, S Peter, R Erber, C Aurich, M Drillich, C Gabler
Repeat breeder cows (RBC) are defined as cyclic cows without clinical abnormalities that fail to conceive after at least three subsequent inseminations. Previous studies have elucidated cellular defence mechanisms in the bovine uterus but detailed information on inflammatory events of endometrial cells in RBC is still lacking. Thus, the objective of this study was to analyse endometrial mRNA expression of selected transcripts associated with uterine inflammatory processes. Cytobrush samples from 91 RBC and 11 synchronised heifers with no history of gynaecological abnormalities (controls, CON) were collected...
March 1, 2017: Theriogenology
https://www.readbyqxmd.com/read/28152410/semen-quality-and-insulin-like-factor-3-associations-with-urinary-and-seminal-levels-of-phthalate-metabolites-in-adult-males
#11
Wei-Hsiang Chang, Meng-Hsing Wu, Hsien-An Pan, Pao-Lin Guo, Ching-Chang Lee
Certain phthalates have adverse effects on male reproductive functions in animals, and potentially affect human testicular function and spermatogenesis, but little is known about the active mechanisms. We measured the urinary and seminal phthalate metabolites and explored their associations on insulin-like factor 3 (INSL3) and semen quality. Urine, blood, and semen samples were collected from the male partners of subfertile (n = 253) and fertile (n = 37) couples in a reproductive center in southern Taiwan...
January 16, 2017: Chemosphere
https://www.readbyqxmd.com/read/28131504/childhood-cancer-risk-in-the-siblings-and-cousins-of-men-with-poor-semen-quality
#12
Ross E Anderson, Heidi A Hanson, William T Lowrance, Jeffrey Redshaw, Siam Oottamasathien, Anthony Schaeffer, Erica Johnstone, Kenneth I Aston, Douglas T Carrell, Patrick Cartwright, Ken R Smith, James M Hotaling
PURPOSE: Poor semen quality is associated with reduced somatic health and increased cancer risk. Infertility and cancer are increasingly being linked by epidemiologists and basic scientists. We sought to identify semen parameters associated with an increased childhood cancer risk in the family members of subfertile men. MATERIALS AND METHODS: We performed a retrospective cohort study in men from the SHARE (Subfertility Heath and Assisted Reproduction) study who underwent semen analysis between 1994 and 2011...
January 25, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28125970/the-use-of-the-mhealth-program-smarter-pregnancy-in-preconception-care-rationale-study-design-and-data-collection-of-a-randomized-controlled-trial
#13
Matthijs R van Dijk, Elsje C Oostingh, Maria P H Koster, Sten P Willemsen, Joop S E Laven, Régine P M Steegers-Theunissen
BACKGROUND: Unhealthy nutrition and lifestyle contribute to the worldwide rising prevalence of non-communicable diseases. This also accounts for the reproductive population, in which unhealthy behavior affects fertility and pregnancy outcome. Maternal smoking, alcohol consumption and inadequate folic acid supplement use are strongly associated with fetal complications as small for gestational age, premature birth and congenital malformations. In the Netherlands 83% of the perinatal mortality rate is due to these complications and is relatively high compared to other European countries...
January 26, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28122315/intrauterine-insemination-no-more-mr-n-i-c-e-guy
#14
Minna E Geisler, Mark Ledwidge, Margaret Bermingham, Mary McAuliffe, Moya B McMenamin, John J Waterstone
OBJECTIVE: To determine the per cycle chance of a live birth and to identify factors that may support a more individualised application of IUI in view of National Institute for Health and Care Excellence (NICE) updated guideline on fertility 2013. STUDY DESIGN: A retrospective, cohort study of 851 couples (1688 cycles) with unexplained, mild endometriosis, one patent Fallopian tube (with ovulation occurring in the corresponding ovary), mild male factor or ovulatory dysfunction, who initiated their first cycle of IUI/COH during the study period 2009-2013 and completed up to 3 cycles...
January 18, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28119447/equipoise-and-the-rct
#15
REVIEW
M Braakhekke, F Mol, S Mastenbroek, B Willem J Mol, F van der Veen
Clinical decisions in reproductive medicine are often made in uncertainty. To reduce uncertainty and to improve clinical decision-making, RCTs are increasingly called upon. A key concept underpinning the ethics of RCTs is equipoise. Here, we aimed to dissect the basic reasoning behind the concept of equipoise and we proposed a line of thinking delineating under which conditions it is ethical to design and execute an RCT. This might prevent a priori negative trials, reduce research waste and aid in the design of meaningful ones...
February 2017: Human Reproduction
https://www.readbyqxmd.com/read/28119161/expression-of-toll-like-receptors-2-4-and-6-in-equine-endometrial-epithelial-cells-a-comparative-in-situ-and-in-vitro-study
#16
Sandra Schöniger, Denny Böttcher, Tobias Theuß, Heinz-Adolf Schoon
Endometrial epithelial cells form a luminal barrier and are exposed to pathogens and non-infectious antigens. Toll-like receptors (TLRs) mediate pathogen defenses and tissue homeostasis, but are also involved in the pathogenesis of inflammatory and fibrosing alterations. Endometrial diseases are important causes of subfertility in mares. The pathogenesis of some types of persistent inflammation and periglandular fibrosis (endometrosis) is unknown. The aim of this study was to compare by in situ and in vitro immunohistochemistry the expression of TLRs 2, 4 and 6 in equine endometrial epithelial cells...
January 12, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28118765/lines
#17
Jacqui O'kane
I wrote this poem while marveling at the birth of my now 4-year-old daughter. My husband Stephen and I had tried to conceive for several months, and we were overjoyed when Sophie finally arrived. Embarking on the fertility journey again - this time with deeper awareness of my own subfertility - I reflect anew on the treasures and travails of pregnancy. Specifically, I have noticed that my greatest hopes hinge on the most miniscule lines of a home pregnancy test. That such small lines could subsume sublime significance is a wonder to me...
January 24, 2017: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28118681/metformin-during-ovulation-induction-with-gonadotrophins-followed-by-timed-intercourse-or-intrauterine-insemination-for-subfertility-associated-with-polycystic-ovary-syndrome
#18
REVIEW
Esmée M Bordewijk, Marleen Nahuis, Michael F Costello, Fulco Van der Veen, Leopoldo O Tso, Ben Willem J Mol, Madelon van Wely
BACKGROUND: Clomiphene citrate (CC) is generally considered first-line treatment in women with anovulation due to polycystic ovary syndrome (PCOS). Ovulation induction with follicle-stimulating hormone (FSH; gonadotrophins) is second-line treatment for women who do not ovulate or conceive while taking CC. Metformin may increase the effectiveness of ovulation induction with gonadotrophins and may promote safety by preventing multiple pregnancy. OBJECTIVES: To determine the effectiveness and safety of metformin co-treatment during ovulation induction with gonadotrophins with respect to rates of live birth and multiple pregnancy in women with PCOS...
January 24, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28111738/interventions-for-the-prevention-of-ohss-in-art-cycles-an-overview-of-cochrane-reviews
#19
REVIEW
Selma Mourad, Julie Brown, Cindy Farquhar
BACKGROUND: Ovarian hyperstimulation syndrome (OHSS) in assisted reproductive technology (ART) cycles is a treatment-induced disease that has an estimated prevalence of 20% to 33% in its mild form and 3% to 8% in its moderate or severe form. These numbers might even be higher for high-risk women such as those with polycystic ovaries or a high oocyte yield from ovum pickup. OBJECTIVES: The objective of this overview is to identify and summarise all evidence from Cochrane systematic reviews on interventions for prevention or treatment of moderate, severe and overall OHSS in couples with subfertility who are undergoing ART cycles...
January 23, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28111341/dysregulation-of-long-noncoding-rnas-in-mouse-testes-and-spermatozoa-after-exposure-to-cadmium
#20
Fengxin Gao, Peng Zhang, Hongyan Zhang, Yunhui Zhang, Yunwen Zhang, Qingyun Hao, Xiaoning Zhang
There is increasing evidence that cadmium (Cd) exposure can cause male subfertility and even complete infertility in mammals. Long noncoding (lnc) RNAs are critical for spermatogenesis, and their dysregulation might lead to male infertility. However, whether they are involved in Cd-induced subfertility is unknown. Here we found that intraperitoneal exposure to Cd in mice led to male subfertility indicated by reductions in testicular sperm production and motility, and by abnormal morphology. Testicular and sperm RNAs were used to investigate lncRNA expression profiles by strand-specific RNA sequencing at the transcriptome level to help determine any RNA-related mechanisms in Cd-induced subfertility...
January 19, 2017: Biochemical and Biophysical Research Communications
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