keyword
MENU ▼
Read by QxMD icon Read
search

Skeptic

keyword
https://www.readbyqxmd.com/read/27913357/introducing-a-stable-bootstrap-validation-framework-for-reliable-genomic-signature-extraction
#1
Nikolaos-Kosmas Chlis, Ekaterini S Bei, Michael Zervakis
The application of machine learning methods for the identification of candidate genes responsible for phenotypes of interest, such as cancer, is a major challenge in the field of bioinformatics. These lists of genes are often called genomic signatures and their linkage to phenotype associations may form a significant step in discovering the causation between genotypes and phenotypes. Traditional methods that produce genomic signatures from DNA Microarray data tend to extract significantly different lists under relatively small variations of the training data...
November 29, 2016: IEEE/ACM Transactions on Computational Biology and Bioinformatics
https://www.readbyqxmd.com/read/27909737/-attitudes-towards-psychotherapy-in-south-korea-and-germany-a%C3%A2-cross-cultural-comparative-study
#2
W Schulz, M A Shin, G Schmid-Ott
BACKGROUND: Due to the relatively recent introduction of psychotherapy in South Korea and against the background of collectivist and Confucian values, it has been suggested that South Koreans harbor more negative attitudes towards psychotherapy compared to Germans and that the social acceptance of psychotherapy is lower. METHODS: We compared the attitudes of 99 women from South Korea with 98 German women using the questionnaire on attitudes towards psychotherapeutic treatment (FEP)...
December 1, 2016: Der Nervenarzt
https://www.readbyqxmd.com/read/27906028/re-focusing-hiv-prevention-messages-a-qualitative-study-in-rural-uganda
#3
Sanyukta Mathur, Dina Romo, Mariko Rasmussen, Neema Nakyanjo, Fred Nalugoda, John S Santelli
BACKGROUND: After 30 years, the human immunodeficiency virus (HIV) remains an epidemic of global concern. To support the increasing emphasis on biomedical interventions for prevention requires a renewed and reframed focus on HIV prevention messages to motivate engagement in risk-reduction activities. This paper examines youth and adult perceptions of HIV prevention messages and HIV risk assessment in a generalized HIV epidemic context in Uganda. METHODS: We conducted 24 focus group discussions and 24 in-depth interviews with 15-45 year olds (n = 218) from three communities in the Rakai district of Uganda in 2012...
November 11, 2016: AIDS Research and Therapy
https://www.readbyqxmd.com/read/27902502/zika-virus-and-patient-blood-management
#4
Lawrence T Goodnough, Marisa B Marques
Sporadic Zika virus infections had only occurred in Africa and Asia until an outbreak in Micronesia (Oceania) in 2007. In 2013 to 2014, several outer Pacific Islands reported local outbreaks. Soon thereafter, the virus was likely introduced in Brazil from competing athletes from French Polynesia and other countries that participated in a competition there. Transmission is thought to have occurred through mosquito bites and spread to the immunologically naive population. Being also a flavivirus, the Zika virus is transmitted by the Aedes mosquito that is endemic in South and Central America that is also the vector of West Nile virus, dengue, and chikungunya...
November 29, 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27895516/a-prospective-observational-study-comparing-the-pk-pd-relationships-of-generic-meropenem-mercide-%C3%A2-to-the-innovator-brand-in-critically-ill-patients
#5
Mervyn Mer, Jacques Rene Snyman, Constance Elizabeth Jansen van Rensburg, Jacob John van Tonder, Ilze Laurens
INTRODUCTION: Clinicians' skepticism, fueled by evidence of inferiority of some multisource generic antimicrobial products, results in the underutilization of more cost-effective generics, especially in critically ill patients. The aim of this observational study was to demonstrate equivalence between the generic or comparator brand of meropenem (Mercide(®)) and the leading innovator brand (Meronem(®)) by means of an ex vivo technique whereby antimicrobial activity is used to estimate plasma concentration of the active moiety...
2016: Clinical Pharmacology: Advances and Applications
https://www.readbyqxmd.com/read/27894379/pr%C3%A3-cis-of-talking-to-our-selves-reflection-ignorance-and-agency
#6
John M Doris
Does it make sense for people to hold one another responsible for what they do, as happens in countless social interactions every day? One of the most unsettling lessons from recent psychological research is that people are routinely mistaken about the origins of their behavior. Yet philosophical orthodoxy holds that the exercise of morally responsible agency typically requires accurate self-awareness. If the orthodoxy is right, and the psychology is to be believed, people characteristically fail to meet the standards of morally responsible agency, and we are faced with the possibility of skepticism about agency...
November 29, 2016: Behavioral and Brain Sciences
https://www.readbyqxmd.com/read/27885325/current-role-of-minimally-invasive-radical-cholecystectomy-for-gallbladder-cancer
#7
REVIEW
Giuseppe Zimmitti, Alberto Manzoni, Francesca Guerini, Marco Ramera, Paola Bertocchi, Francesca Aroldi, Alberto Zaniboni, Edoardo Rosso
Background. For Tis and T1a gallbladder cancer (GbC), laparoscopic cholecystectomy can provide similar survival outcomes compared to open cholecystectomy. However, for patients affected by resectable T1b or more advanced GbC, open approach radical cholecystectomy (RC), consisting in gallbladder liver bed resection or segment 4b-5 bisegmentectomy, with locoregional lymphadenectomy, is considered the gold standard while minimally invasive RC (MiRC) is skeptically considered. Aim. To analyze current literature on perioperative and oncologic outcomes of MiRC for patients affected by GbC...
2016: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/27882040/a-new-model-of-master-of-philosophy-in-physiological-sciences
#8
H R Ahmad, F M Arain, N A Khan
The objectives of Master of Philosophy (MPhil) in Physiological Sciences are: 1) to describe the new ways in which anatomy, biochemistry and physiology on one hand, and microbiology, pathology and pharmacology on other hand meet their functional requirements through multidisciplinary integrated concepts; 2) to elucidate relationships between cell biology, molecular biology and molecular genetics by connecting dots of how cell functions are driven by molecules and being controlled by genes. This forms the basis of cell, molecular and genetics [CMG] module upon which 7 multidisciplinary modules of Physiological Sciences follow; 3) these 24 credit hours provide the physiological basis for PhD studies as well as faculty development to enhance learning abilities of medical student; 4) the modules constitute Cardio- Respiratory Physiological Sciences, GI and Renal Physiological Sciences, Neurosciences, Endo-Reproductive Physiological Sciences...
September 2016: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/27876133/skin-phenotypes-can-offer-some-insight-about-the-association-between-telomere-length-and-cancer-susceptibility
#9
S Ribero, M Mangino, V Bataille
The role of telomere biology in cancer has been studied for a wide variety of different cancers but the association with telomere length has been controversial. This is because some cancers have been found to be associated with longer telomeres in circulating white cells whilst other cancer types are more common in individuals with shorter telomeres. Hence, there has been some skepticism as to whether telomere length may be helpful in estimating cancer risk. For melanoma, however, results have been fairly consistent showing that longer telomeres are associated with an increased risk...
December 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27875644/skepticism-in-the-genomic-era
#10
Rachel L Zacharias
I joined The Hastings Center this past summer, after graduating from Duke University, where I researched advancements in neuroscience and genomics and their import for law, ethics, and policy. This research required, to an extent, faith in the idea that researchers can identify pathways by which genes combine with epigenetic and environmental factors to affect neuronal activity and influence behaviors. Throughout my first months here, I have puzzled over broad critiques of "genomic hype" in recent literature, which clash with the optimistic rhetoric found in the Human Genome Project and the Precision Medicine Initiative...
November 2016: Hastings Center Report
https://www.readbyqxmd.com/read/27857775/re-focusing-hiv-prevention-messages-a-qualitative-study-in-rural-uganda
#11
Sanyukta Mathur, Dina Romo, Mariko Rasmussen, Neema Nakyanjo, Fred Nalugoda, John S Santelli
BACKGROUND: After 30 years, the human immunodeficiency virus (HIV) remains an epidemic of global concern. To support the increasing emphasis on biomedical interventions for prevention requires a renewed and reframed focus on HIV prevention messages to motivate engagement in risk-reduction activities. This paper examines youth and adult perceptions of HIV prevention messages and HIV risk assessment in a generalized HIV epidemic context in Uganda. METHODS: We conducted 24 focus group discussions and 24 in-depth interviews with 15-45 year olds (n = 218) from three communities in the Rakai district of Uganda in 2012...
2016: AIDS Research and Therapy
https://www.readbyqxmd.com/read/27853009/outcome-of-transplanted-donor-corneas-with-more-than-6-h-of-death-to-preservation-time
#12
Ashik Mohamed, Sunita Chaurasia, Prashant Garg
PURPOSE: In tropical countries, physicians are skeptic in using corneas with death-to-preservation time (DTPT) >6 h, concerns being endothelial cell viability and microbial contamination on prolonged DTPT. The objective of the study was to investigate these concerns by analyzing the outcomes of corneal transplants performed using donor corneas with DTPT >6 h. MATERIALS AND METHODS: The study was a retrospective case series of 65 transplants performed in 2013 with donor corneas that had DTPT >6 h (range, 6...
September 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/27847912/testosterone-therapy-in-men-with-testosterone-deficiency-are-we-beyond-the-point-of-no-return
#13
REVIEW
Abdulmaged Traish
Although testosterone therapy in men with testosterone deficiency was introduced in the early 1940s, utilization of this effective treatment approach in hypogonadal men is met with considerable skepticism and resistance. Indeed, for decades, the fear that testosterone may cause prostate cancer has hampered clinical progress in this field. Nevertheless, even after considerable knowledge was acquired that this fear is unsubstantiated, many in the medical community remain hesitant to utilize this therapeutic approach to treat men with hypogonadism...
November 2016: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/27847349/assessing-the-viability-of-social-media-for-disseminating-evidence-based-nutrition-practice-guideline-through-content-analysis-of-twitter-messages-and-health-professional-interviews-an-observational-study
#14
Rosa K Hand, Deric Kenne, Taylor M Wolfram, Jenica K Abram, Michael Fleming
BACKGROUND: Given the high penetration of social media use, social media has been proposed as a method for the dissemination of information to health professionals and patients. This study explored the potential for social media dissemination of the Academy of Nutrition and Dietetics Evidence-Based Nutrition Practice Guideline (EBNPG) for Heart Failure (HF). OBJECTIVES: The objectives were to (1) describe the existing social media content on HF, including message content, source, and target audience, and (2) describe the attitude of physicians and registered dietitian nutritionists (RDNs) who care for outpatient HF patients toward the use of social media as a method to obtain information for themselves and to share this information with patients...
November 15, 2016: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/27847132/weight-loss-drugs-and-lifestyle-modification-perceptions-among-a-diverse-adult-sample
#15
S Xing, L K Sharp, D R Touchette
OBJECTIVES: Explore how adults from diverse racial and socioeconomic backgrounds perceive the use of weight loss drugs (prescription, over-the counter, herbals and supplements) and lifestyle modification. METHODS: Individual, face-to-face, semi-structured interviews were conducted with persons presenting to an academic hospital-affiliated outpatient pharmacy serving ethnic minorities and low income individuals. RESULTS: Fifty persons were interviewed, including 21 African Americans, 11 Hispanics and 17 low-income individuals (annual income <$20,000), of whom 33 self-reported as overweight or obese...
November 9, 2016: Patient Education and Counseling
https://www.readbyqxmd.com/read/27834237/promoting-health-equity-and-population-health-how-americans-views-differ
#16
Larry Bye, Alyssa Ghirardelli, Angela Fontes
To increase understanding of what Americans think about personal and public health, a national survey of US adults was conducted in 2015-16 to develop a typology of values and beliefs. The survey was commissioned by the Robert Wood Johnson Foundation for its Culture of Health initiative. Six specific population groupings, or segments, were identified. Three segments included people who supported an active government role in health, two segments were characterized by people who were skeptical toward government, and one segment was characterized by people with conflicted attitudes toward government in health...
November 1, 2016: Health Affairs
https://www.readbyqxmd.com/read/27832953/randomized-trials-addressing-a-similar-question-are-commonly-published-after-a-trial-stopped-early-for-benefit
#17
M Hassan Murad, Gordon H Guyatt, Juan Pablo Domecq, Robin W M Vernooij, Patricia J Erwin, Joerg J Meerpohl, Gabriela J Prutsky, Elie A Akl, Katharina Mueller, Dirk Bassler, Stefan Schandelmaier, Stephen D Walter, Jason W Busse, Benjamin Kasenda, Gennaro Pagano, Hector Pardo-Hernandez, Victor M Montori, Zhen Wang, Matthias Briel
OBJECTIVE: We explored how investigators of ongoing or planned trials respond to the publication of a trial stopped early for benefit addressing a similar question. STUDY DESIGN AND SETTING: We searched multiple databases from the date of publication of the truncated trial through August, 2015. Independent reviewers selected trials and extracted data. RESULTS: We identified 207 trials truncated for early benefit; of which 102 (49%) were followed by subsequent trials (262 subsequent trials, median 2 per truncated trial, range 1-13)...
November 7, 2016: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/27825355/seahorses-in-focus-local-ecological-knowledge-of-seahorse-watching-operators-in-a-tropical-estuary
#18
Maria L F Ternes, Leopoldo C Gerhardinger, Alexandre Schiavetti
BACKGROUND: Seahorses are endangered teleost fishes under increasing human pressures worldwide. In Brazil, marine conservationists and policy-makers are thus often skeptical about the viability of sustainable human-seahorse interactions. This study focuses on local ecological knowledge on seahorses and the implications of their non-lethal touristic use by a coastal community in northeastern Brazil. Community-based seahorse-watching activities have been carried out in Maracaípe village since 1999, but remained uninvestigated until the present study...
November 8, 2016: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/27825187/-exposure-to-limited-resources-in-the-gastroenterology-results-of-a-survey-of-hospital-physicians
#19
L Kerkemeyer, A Reifferscheid, N Pomorin, J Wasem
Background and research question: The hospital sector is currently characterized by a high economic pressure. As well the DRG system as the investment financing by the federal states imply financial limitations. Hospitals react to this situation by trying to reduce costs and to increase case volume. It is questionable whether and to what extent patient care and the working conditions of the physicians are affected by these circumstances. Especially, gastroenterological patients were considered to be insufficiently covered by the DRG system in the past...
November 2016: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/27822520/getting-the-hologenome-concept-right-an-eco-evolutionary-framework-for-hosts-and-their-microbiomes
#20
Kevin R Theis, Nolwenn M Dheilly, Jonathan L Klassen, Robert M Brucker, John F Baines, Thomas C G Bosch, John F Cryan, Scott F Gilbert, Charles J Goodnight, Elisabeth A Lloyd, Jan Sapp, Philippe Vandenkoornhuyse, Ilana Zilber-Rosenberg, Eugene Rosenberg, Seth R Bordenstein
Given the complexity of host-microbiota symbioses, scientists and philosophers are asking questions at new biological levels of hierarchical organization-what is a holobiont and hologenome? When should this vocabulary be applied? Are these concepts a null hypothesis for host-microbe systems or limited to a certain spectrum of symbiotic interactions such as host-microbial coevolution? Critical discourse is necessary in this nascent area, but productive discourse requires that skeptics and proponents use the same lexicon...
March 2016: MSystems
keyword
keyword
102213
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"