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https://www.readbyqxmd.com/read/28183085/reviving-research-on-medication-attitudes-for-improving-pharmacotherapy-focusing-on-adherence
#1
Carlos De Las Cuevas, Jose de Leon
There is little current interest in research into patients' attitudes toward medications. In the 1960s, psychiatric researchers including Uhlenhuth, Rickels and Covi focused on this area, but this research topic needs to be revived in the 21st century. The Health Belief Model may hold potential for doing this. This model was initially developed by 2 health psychologists, Rosenstock and Becker, to explain why patients did not follow medical interventions. The application of this model to study medication adherence in psychiatric outpatients has provided multiple findings including the conclusions that adherence is associated with: (1) the balance between internal and external health control beliefs, (2) psychological reactance, (3) patients' attitudes toward prescribed drug treatment in general and (4) the balance between the necessity of taking medications versus the concerns derived from adverse drug reactions (ADRs)...
February 10, 2017: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/28179715/integration-of-basic-and-clinical-science-courses-in-us-pharmd-programs
#2
Mohammed A Islam, Rahmat M Talukder, Reza Taheri, Nicholas Blanchard
Objective. To determine the current status of and faculty perceptions regarding integration of basic and clinical science courses in US pharmacy programs. Methods. A 25-item survey instrument was developed and distributed to 132 doctor of pharmacy (PharmD) programs. Survey data were analyzed using Mann-Whitney U test or Kruskal-Wallis test. Thematic analysis of text-based comments was performed using the constant comparison method. Results. One hundred twelve programs responded for a response rate of 85%. Seventy-eight (70%) offered integrated basic and clinical science courses...
December 25, 2016: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/28179431/repeated-cell-therapy-a-paradigm-shift-whose-time-has-come
#3
Roberto Bolli
Although treatment with stem/progenitor cells is a promising approach to heart disease, enthusiasm for cell therapy has been dampened by the inconsistent, modest, borderline, or undetectable benefits reported in clinical trials (all of which have used one dose of cells). As a result, clinical translation has not occurred (no cell-based therapy is close to being approved for heart disease), and a rising tide of skepticism has bedeviled the field,leading some critics even to question whether clinical studies should continue...
February 8, 2017: Circulation Research
https://www.readbyqxmd.com/read/28178993/perspectives-of-urban-ghanaian-women-on-vasectomy
#4
Ofeibea Asare, Easmon Otupiri, Joana Apenkwa, Rose Odotei-Adjei
BACKGROUND: Advocacy for male involvement in family planning has been championed over the years after the 1994 International Conference on Population and Development (ICPD). There are a few contraceptive methods for men, and vasectomy uptake has been identified as one of the indicators of male involvement in family planning. Vasectomy also known as male sterilization is a permanent form of contraception. It is a generally safe, quick, easy, effective surgical operation with rare complications to prevent release of sperm...
February 8, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28156545/the-influence-of-spirituality-and-religiosity-on-the-personal-use-and-practice-patterns-with-complementary-and-alternative-medicine-cam-a-national-survey-of-us-oncologists
#5
Catherine Powers-James, Adriana L Alvarez, Kathrin Milbury, Francoise Adan, Gabriel Lopez, Lorenzo Cohen, Marvin Delgado-Guay, Olufunmilayo I Olopade, Farr A Curlin
: 248 Background: Although cancer patients frequently use CAM, it is uncertain how oncologists' spirituality and religiosity impact their decisions to use or recommend CAM with their patients. METHODS: A US probability sample of 1,000 ASCO members was contacted by mail and email to complete a survey regarding clinical approaches to herb and supplement (HS) use by cancer patients. RESULTS: Of 927 deliverable surveys, 423 surveys were returned for a response rate of 46%...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28156475/usability-and-acceptance-of-novel-personal-health-technology-to-support-early-palliative-care-for-patients-with-cancer-and-caregivers
#6
Sarah C Reed, Katherine Kim, Victoria Ngo, Wendy Wait, Ester Apesoa-Varano, Joy Morgan, Robin L Whitney, Emma Blackmon, Jill Joseph
: 73 Background: Little research has assessed whether and how technology can support early palliative care. Our team developed a HIPAA-compliant, cloud-based Personal Health Network (PHN) with a secure, online network of family, caregivers, clinicians and service providers designated by the patient; symptom reporting/management resources; and support for communication among network members via audio/video conferencing, messaging, and document sharing. This study examines PHN usability and acceptance, and identifies additional functions for early palliative care...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28151523/-equivalence-equity-and-evidence-for-the-use-of-biosimilar-drugs
#7
Francesco Trotta, Antonio Addis
At present, biosimilar drugs are one of the potential tools capable to allow the access to biological pharmacotherapy in a context of limited resources. Even though universal standards have been determined, prescribers are often unaware of the meaning of the evaluation which assures correct equivalence of biosimilar with the originator product. On the other hand, comparative efficacy and safety studies between biosimilars and originators are often lacking. These might be some of the limiting factors for a wider use of such therapeutic tools by the health practitioners...
2017: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/28149628/subxiphoid-video-assisted-major-lung-resections-the-skeptic-s-speech
#8
COMMENT
Alberto Terzi, Andrea Viti
No abstract text is available yet for this article.
December 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28147370/does-the-introduction-of-biosimilars-change-our-understanding-about-treatment-modalities-for-inflammatory-bowel-disease
#9
L Buer, M L Høivik, A W Medhus, B Moum
BACKGROUND: Biological agents, mainly tumor necrosis factor-α inhibitors, play an important role in the treatment of inflammatory bowel disease (IBD). These drugs are expensive and constitute a major cost in the IBD care. In 2013, the first biosimilar monoclonal antibody, infliximab (IFX), was approved in the EU. Key Messages: There has been considerable skepticism regarding the use of biosimilars. Both clinicians and patients have questioned the safety and efficacy of these new drugs...
2017: Digestive Diseases
https://www.readbyqxmd.com/read/28141964/spatial-self-organization-of-ecosystems-integrating-multiple-mechanisms-of-regular-pattern-formation
#10
Robert M Pringle, Corina E Tarnita
Large-scale regular vegetation patterns are common in nature, but their causes are disputed. Whereas recent theory focuses on scale-dependent feedbacks as a potentially universal mechanism, earlier studies suggest that many regular spatial patterns result from territorial interference competition between colonies of social-insect ecosystem engineers, leading to hexagonally overdispersed nest sites and associated vegetation. Evidence for this latter mechanism is scattered throughout decades of disparate literature and lacks a unified conceptual framework, fueling skepticism about its generality in debates over the origins of patterned landscapes...
January 31, 2017: Annual Review of Entomology
https://www.readbyqxmd.com/read/28134573/measuring-resilience
#11
Robert R Hoffman, P A Hancock
OBJECTIVE: As human factors and ergonomics (HF/E) moves to embrace a greater systems perspective concerning human-machine technologies, new and emergent properties, such as resilience, have arisen. Our objective here is to promote discussion as to how to measure this latter, complex phenomenon. BACKGROUND: Resilience is now a much-referenced goal for technology and work system design. It subsumes the new movement of resilience engineering. As part of a broader systems approach to HF/E, this concept requires both a definitive specification and an associated measurement methodology...
January 1, 2017: Human Factors
https://www.readbyqxmd.com/read/28132746/acc-aha-special-report-clinical%C3%A2-practice-guideline-implementation-strategies-a%C3%A2-summary-of-systematic-reviews-by-the-nhlbi-implementation-science-work-group-a-report-of-the-american-college-of-cardiology-american-heart-association-task-force-on-clinical-practice
#12
Wiley V Chan, Thomas A Pearson, Glen C Bennett, William C Cushman, Thomas A Gaziano, Paul N Gorman, Joel Handler, Harlan M Krumholz, Robert F Kushner, Thomas D MacKenzie, Ralph L Sacco, Sidney C Smith, Victor J Stevens, Barbara L Wells
BACKGROUND: In 2008, the National Heart, Lung, and Blood Institute convened an Implementation Science Work Group to assess evidence-based strategies for effectively implementing clinical practice guidelines. This was part of a larger effort to update existing clinical practice guidelines on cholesterol, blood pressure, and overweight/obesity. OBJECTIVES: Review evidence from the published implementation science literature and identify effective or promising strategies to enhance the adoption and implementation of clinical practice guidelines...
January 18, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28128984/implementing-neoadjuvant-endocrine-strategies-in-er-positive-her2-negative-breast-cancer
#13
Alexios Matikas, Theodoros Foukakis, Ilias Michalakis, Vassilis Georgoulias
Although neoadjuvant chemotherapy has been widely adopted as it increases breast conservation rates, permits the in vivo testing of the activity of chemotherapeutics and offers the opportunity to conduct translational research based on longitudinal assessments of tumor tissue, neoadjuvant endocrine therapy has been met with skepticism owing to slow regression rates and a low chance for pathologic remission. Areas Covered: Herein, the results of clinical trials comparing different endocrine agents as neoadjuvant treatment, endocrine therapy with chemotherapy, treatment duration, novel combinations and putative biomarkers are reviewed, with the aim to better understand the current and future role of this modality in clinical practice...
January 27, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/28126839/acc-aha-special-report-clinical-practice-guideline-implementation-strategies-a-summary-of-systematic-reviews-by-the-nhlbi-implementation-science-work-group-a-report-of-the-american-college-of-cardiology-american-heart-association-task-force-on-clinical-practice
#14
Wiley V Chan, Thomas A Pearson, Glen C Bennett, William C Cushman, Thomas A Gaziano, Paul N Gorman, Joel Handler, Harlan M Krumholz, Robert F Kushner, Thomas D MacKenzie, Ralph L Sacco, Sidney C Smith, Victor J Stevens, Barbara L Wells, Graciela Castillo, Susan K R Heil, Jennifer Stephens, Julie C Jacobson Vann
BACKGROUND: In 2008, the National Heart, Lung, and Blood Institute convened an Implementation Science Work Group to assess evidence-based strategies for effectively implementing clinical practice guidelines. This was part of a larger effort to update existing clinical practice guidelines on cholesterol, blood pressure, and overweight/obesity. OBJECTIVES: Review evidence from the published implementation science literature and identify effective or promising strategies to enhance the adoption and implementation of clinical practice guidelines...
January 26, 2017: Circulation
https://www.readbyqxmd.com/read/28119069/more-childhood-onset-bipolar-disorder-in-the-united-states-than-canada-or-europe-implications-for-treatment-and-prevention
#15
REVIEW
Robert M Post, Lori L Altshuler, Ralph Kupka, Susan L McElroy, Mark A Frye, Michael Rowe, Heinz Grunze, Trisha Suppes, Paul E Keck, Gabriele S Leverich, Willem A Nolen
Evidence of a high or increasing incidence of childhood onset bipolar disorder in the United States (US) has been viewed skeptically. Here we review evidence that childhood onsets of bipolar disorder are more common in the US than in Europe, treatment delays are longer, and illness course is more adverse and difficult. Epidemiological data and studies of offspring at high risk also support these findings. In our cohort of outpatients with bipolar disorder, two of the major vulnerability factors for early onset - genetics and environmental adversity in childhood - were also greater in the US than in Europe...
January 21, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28118420/patient-experiences-of-therapeutic-jaw-exercises-in-the-treatment-of-masticatory-myofascial-pain-a-qualitative-study
#16
Erik Lindfors, Eva Hedman, Tomas Magnusson, Malin Ernberg, Pia Gabre
AIMS: To investigate patients' experiences of therapeutic jaw exercises for treating masticatory myofascial pain. METHODS: A total of 10 patients were selected for the interview study. All patients had received treatment with jaw exercises at a specialist clinic. Semi-structured interviews were conducted in a nonclinical environment according to an interview guide with 10 domains. The interviews were transcribed and translated into English. Systematic text condensation (STC) was used to arrange and analyze the text material...
January 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/28116535/investigation-of-photobiomodulation-potentiality-by-635-and-809%C3%A2-nm-lasers-on-human-osteoblasts
#17
Gamze Bölükbaşı Ateş, Ayşe Ak Can, Murat Gülsoy
Photobiomodulation (PBM) describes light-induced photochemical reactions achieved by the application of red or near infrared lasers/LED light with low energy densities. This noninvasive and painless method has been used in some clinical areas but controversial outcomes demand a skeptical look for its promising and potential effects. In this detailed in vitro study, the osteoblast cells were irradiated with 635 and 809 nm diode lasers at energy densities of 0.5, 1, and 2 J/cm(2). Cell viability, proliferation, bone formation, and osteoblast differentiation were evaluated by methylthiazole tetrazolium (MTT) assay, Alamar Blue assay, acridine orange/propidium iodide staining, alkaline phosphatase (ALP) activity, Alizarin red staining, and reverse-transcription polymerase chain reaction (RT-PCR) to test the expression of collagen type I, ALPL, and osteocalcin...
January 23, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28115076/cognitive-bias-and-the-creation-and-translation-of-evidence-into-clinical-practice
#18
REVIEW
Donald A Molony
The optimal translation of evidence into the clinical practice of nephrology follows validated evidence-based medicine (EBM) principles. Most importantly, the evidence-based medicine practitioner requires that the evidence, as much as possible, addresses in an unbiased manner clinical questions of importance to patients and reflects the truth. In this chapter, we evaluate how cognitive biases that affect medical decision making might systematically bias the overall management of patients with kidney disease and, thus, distort the observations about disease causation, prognosis, diagnosis, and management that are derived from analysis of administrative databases or electronic medical records of health care systems...
November 2016: Advances in Chronic Kidney Disease
https://www.readbyqxmd.com/read/28101268/traditional-versus-online-biology-courses-connecting-course-design-and-student-learning-in-an-online-setting
#19
Rachel Biel, Cynthia J Brame
Online courses are a large and growing part of the undergraduate education landscape, but many biology instructors are skeptical about the effectiveness of online instruction. We reviewed studies comparing the effectiveness of online and face-to-face (F2F) undergraduate biology courses. Five studies compared student performance in multiple course sections at community colleges, while eight were smaller scale and compared student performance in particular biology courses at a variety of types of institutions...
December 2016: Journal of Microbiology & Biology Education: JMBE
https://www.readbyqxmd.com/read/28096866/disseminated-strongyloidiasis-in-an-iranian-immunocompromised-patient-a-case-report
#20
Narges Najafi, Eissa Soleymani, Shahabeddin Sarvi, Amirkeivan Marofi, Anahita Nosrati, Alireza Davoodi
Strongyloides stercoralis is a soil-transmitted helminth (STH) widespread in various part of the world. A 78-yr-old peasant diabetic female from Mazandaran Province northern Iran, was admitted to Infection Department of the Razi Hospital in city of Qaemshahr, north of Iran complaining about abdominal skin rash, pruritus, itching, anorexia, nausea, vomiting, dysuria and cough. This patient had cutaneous migration effects of S. stercoralis larvae in her abdominal skin (larva currents and urticaria). Lung CT without contrast demonstrate s bilateral diffuse ground glass opacity draws attention...
April 2016: Iranian Journal of Parasitology
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