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https://www.readbyqxmd.com/read/29781089/the-effect-of-topical-piperine-combined-with-narrowband-uvb-on-vitiligo-treatment-a-clinical-trial-study
#1
Anoosh Shafiee, Mahmood Hoormand, Mohammad Shahidi-Dadras, Alireza Abadi
Vitiligo is the most common acquired hypopigmentary disease in the community. Piperine as an herbal extract derived from black pepper has strong impact on the melanocyte proliferation and adverse side effects less than synthetic drugs such as corticosteroids. For the first time, this study was aimed to evaluate the effect of topical piperine combined with narrowband ultraviolet B (NB-UVB) on vitiligo treatment. In this double-blind clinical trial, 63 patients with facial vitiligo were randomly divided into 2 groups: treated with piperine (case) and placebo (control)...
May 21, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29770152/efficacy-and-safety-of-indigo-naturalis-in-combination-with-narrow-band-ultraviolet-b-for-treatment-of-pityriasis-rosea-a-meta-analysis
#2
L Wang, Y N Xue, Z W Li, W Zhang, X P Ji, Z Fan, Y J Li
Pityriasis rosea (PR), a skin rash, causes substantial discomfort in patients. There is a lack of effective therapies for PR. A combination of ultraviolet irradiation and indigo naturalis treatment has been shown to be a safe and effective regime for control of PR; however, the data have been largely inconsistent. Tis meta-analysis further evaluated the efficacy and safety of this combination in patients with PR. The PubMed, Embase, Cochrane Library, CNKI, VIP, and Wan Fang databases were searched for relevant RCTs of this combination therapy in patients with PR...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29741410/management-of-resistant-halo-nevi
#3
Sherif S Awad, Rasha Ta Abdel Aziz, Sahar S Mohammed
BACKGROUND: Halo nevus (HN) is a rare dermatologic disorder characterized by typical whitish rim surrounding an existing melanocytic nevus resembling halo. It is a cosmetic problem that may be linked to vitiligo, and it is advised to remove these nevi in order to avoid development of vitiligo. OBJECTIVES: The aim of the present study is to evaluate the cosmetic outcome after nevus removal and leukoderma dermabrasion with epithelial graft followed by narrow-band ultraviolet B (NB-UVB) phototherapy as management of resistant halo nevi and avoidance of development of vitiligo...
May 9, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29707896/correlation-between-serum-il-17a-level-and-salt-score-in-patients-with-alopecia-areata-before-and-after-nb-uvb-therapy
#4
Hanan Morsy, Reham Maher, Dalia Negm
BACKGROUND: There is strong evidence that alopecia areata is of immunological background; Interleukin-17 (IL-17) is a Th17 pro-inflammatory cytokine that has been allied to the pathogenesis of different autoimmune and inflammatory diseases. OBJECTIVE: This study aimed to measure serum IL-17A in patients with alopecia areata, and to study associations between IL-17A levels and disease severity before and after Narrowband-Ultraviolet B (NB-UVB), patient gender and age...
April 29, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29707867/combination-of-fractional-carbon-dioxide-laser-with-narrow-band-ultraviolet-b-to-induce-repigmentation-in-stable-vitiligo-a-comparative-study
#5
Noha Nabil Doghaim, Shereen Farouk Gheida, Rania Ahmed El-Tatawy, Dareen Abdelaziz Mohammed Ali
BACKGROUND: Despite the numerous treatment modalities available for vitiligo, responses to treatment are still unsatisfactory. For this reason, new treatment modalities and approaches are needed. OBJECTIVE: To evaluate the efficacy and safety of fractional carbon dioxide (CO2 ) laser therapy followed by narrow band ultraviolet-B (NB-UVB) phototherapy on stable resistant vitiligo. SUBJECTS AND METHODS: Thirty-two patients with stable bilateral vitiligo were enrolled...
April 30, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29615444/home-interventions-and-light-therapy-for-the-treatment-of-vitiligo-hi-light-vitiligo-trial-study-protocol-for-a-randomised-controlled-trial
#6
Rachel H Haines, Kim S Thomas, Alan A Montgomery, Jane C Ravenscroft, Perways Akram, Joanne R Chalmers, Diane Whitham, Lelia Duley, Viktoria Eleftheriadou, Garry Meakin, Eleanor J Mitchell, Jennifer White, Andy Rogers, Tracey Sach, Miriam Santer, Wei Tan, Trish Hepburn, Hywel C Williams, Jonathan Batchelor
INTRODUCTION: Vitiligo is a condition resulting in white patches on the skin. People with vitiligo can suffer from low self-esteem, psychological disturbance and diminished quality of life. Vitiligo is often poorly managed, partly due to lack of high-quality evidence to inform clinical care. We describe here a large, independent, randomised controlled trial (RCT) assessing the comparative effectiveness of potent topical corticosteroid, home-based hand-held narrowband ultraviolet B-light (NB-UVB) or combination of the two, for the management of vitiligo...
April 3, 2018: BMJ Open
https://www.readbyqxmd.com/read/29610017/epidermal-barrier-and-oxidative-stress-parameters-improve-during-in-311-nm-narrow-band-uvb-phototherapy-of-plaque-type-psoriasis
#7
Razvigor Darlenski, Evgeniya Hristakieva, Ufuk Aydin, Desisslava Gancheva, Tanya Gancheva, Antoaneta Zheleva, Veselina Gadjeva, Joachim W Fluhr
BACKGROUND: Psoriasis is a multi-systemic inflammatory disease that results from dysregulation between epidermal keratinocyte homeostasis and both innate and acquired immunity. Epidermal barrier defect has been described in psoriatic lesions. Furthermore an imbalance between pro-oxidative stress and antioxidant defense mechanisms are known in psoriasis patients. AIM: The aim of this study was to address the link between disease activity, epidermal barrier and systemic oxidative stress in the course of 311 nm narrow band ultraviolet B (NB-UVB) therapy of psoriasis...
March 21, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29606819/disseminated-superficial-actinic-porokeratosis-in-a-patient-with-psoriasis-after-long-term-narrowband-ultraviolet-b-phototherapy
#8
Chang Yoon Sim, Ji Yeoun Shin, Sung Yul Lee, Young Lip Park
Porokeratosis is a rare epidermal disorder characterized by annular or linear hyperkeratotic plaques with slightly raised thread-like borders, and in most cases, atrophic centers. Disseminated superficial porokeratosis and disseminated superficial actinic porokeratosis (DSAP), which primarily involve sun-exposed areas, are common types of porokeratoses. Histologically, a column of parakeratotic cells, a so-called cornoid lamella, is a hallmark of porokeratosis. Porokeratosis is considered to result from the inability to eliminate an abnormal keratinocyte clone induced by genetic factors and various stimuli, including sunlight, artificial ultraviolet light, viral infections, immunosuppressive conditions (hematologic malignancies, organ transplants, or autoimmune disease), and immunosuppressive therapies...
April 2018: Annals of Dermatology
https://www.readbyqxmd.com/read/29604040/clinical-and-dermoscopic-response-predictors-in-psoriatic-patients-undergoing-narrowband-ultraviolet-b-phototherapy-results-from-a-prospective-study
#9
Enzo Errichetti, Giuseppe Stinco
BACKGROUND: Although disease severity, gender, body weight, and previous treatments have all been reported to affect clinical response of psoriasis vulgaris to narrowband ultraviolet B (NB-UVB) therapy, little information about possible local (lesional) influencing factors is available. OBJECTIVE: To assess correlations between clinical/dermoscopic findings of psoriatic plaques and therapeutic response to NB-UVB phototherapy in order to find positive and/or negative response predictor factors to such a treatment...
March 31, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29545869/the-effects-of-phototherapy-and-melanocytes-on-keratinocytes
#10
Luyan Tang, Wenyu Wu, Wenwen Fu, Yao Hu
Phototherapy is widely used in the treatment of vitiligo. Previous studies have focused on the effects of ultraviolet (UV) radiation on melanocytes; however, the biological effects of phototherapy and melanocytes on keratinocytes remain to be elucidated. To investigate and assess the effects of clinically doses of broad band (BB)-UVA, narrow band (NB)-UVB and melanocytes on human keratinocytes in vitro , clinical doses of BB-UVA or NB-UVB radiation and human melanoma cell A375 co-culture were performed as stress divisors to HaCaT cells...
April 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29533483/cutaneous-carcinogenic-risk-evaluation-in-375-patients-treated-with-narrowband-uvb-phototherapy-a-15-year-experience-from-our-institute
#11
Beatrice Raone, Annalisa Patrizi, Carlotta Gurioli, Andrea Gazzola, Giulia Maria Ravaioli
BACKGROUND: Narrowband-ultraviolet B (NB-UVB) is widely used for the treatment of several dermatological diseases. A cutaneous carcinogenic effect has been hypothesized, but not proved. METHODS: We retrospectively reviewed the data of patients treated with NB-UVB between January 1998 and December 2013 at the Dermatology Unit of our University Hospital, to evaluate the cutaneous carcinogenic risk of NB-UVB. RESULTS: In all, 375 patients were included, each receiving a mean follow-up of 6...
March 13, 2018: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/29524288/effect-of-narrow-band-ultraviolet-b-on-the-serum-of-25-hydroxyvitamin-d-in-vitiligo-patients
#12
Hassan Ibrahim, Moustafa El Taieb, Zeinab El Gamel, Abdel Rahman El Saied
BACKGROUND: Narrow-band ultraviolet B (NB-UVB) is the gold standard in the treatment of vitiligo. 25-hydroxyvitamin D (25-OH- vitamin D) might play a physiological role in photo-induced melanogenesis in human skin so the association between vitamin D levels and vitiligo still needs to be investigated more thoroughly. OBJECTIVE: we aim to investigate the influence of cumulative doses of NB-UVB phototherapy on vitamin D in patients with vitiligo and their correlation with NB-UVB-induced pigmentation...
March 10, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29483979/micro-focused-phototherapy-associated-to-janus-kinase-inhibitor-a-promising-valid-therapeutic-option-for-patients-with-localized-vitiligo
#13
Serena Gianfaldoni, Georgi Tchernev, Uwe Wollina, Maria Grazia Roccia, Massimo Fioranelli, Jacopo Lotti, Miriam Rovesti, Francesca Satolli, Yan Valle, Andy Goren, Michael Tirant, Mirna Situm, Maja Kovacevic, Katlein França, Torello Lotti
BACKGROUND: Vitiligo is an acquired pigmentary cutaneous disease, characterised by the progressive loss of melanocytes, resulting in hypopigmented skin areas which progressively become amelanotic. Classically, vitiligo treatments are unsatisfactory and challenging. Despite the continuous introduction of new therapies, phototherapy is still the mainstay for vitiligo repigmentation. AIM: The aim of this multicenter observational retrospective study was to evaluate the efficacy and safety of the nb - UVB micro - phototherapy (BIOSKIN EVOLUTION®), used alone or in associations with an oral Janus kinase inhibitor (Tofacitinib citrate), in the treatment of stable or active forms of localised vitiligo...
January 25, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29454820/il12b-il23a-il23r-and-hla-c-06-genetic-variants-in-psoriasis-susceptibility-and-response-to-treatment
#14
Adriana Bojko, Roksana Ostasz, Monika Białecka, Adam Klimowicz, Damian Malinowski, Robert Budawski, Piotr Bojko, Marek Droździk, Mateusz Kurzawski
The role of interleukin-23 is crucial in the pathogenesis of psoriasis, and IL23A, IL12B and IL23R genetic variants have been associated with the disease in genome-wide association studies. In the current paper we have conducted a confirmation study of the abovementioned genetic factors in a case-control analysis of 507 psoriatic patients and 396 controls from a Polish population, and subsequently analyzed the impact of genetic variants on response to topical and NB-UVB therapy in a subset of 306 patients. Case-control analysis revealed an association of IL12B rs3212227 and IL23R rs11209026 minor allele carrier status with reduced odds for psoriasis (OR = 0...
April 2018: Human Immunology
https://www.readbyqxmd.com/read/29444382/a-prospective-right-left-comparative-study-to-evaluate-the-efficacy-and-tolerability-of-combination-of-nb-uvb-and-topical-bimatoprost-0-03-eye-drops-versus-nb-uvb-given-alone-in-patients-of-vitiligo-vulgaris
#15
LETTER
S Sharma, D Parsad, R Bhattacharjee, S K Muthu
No abstract text is available yet for this article.
February 14, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29390261/metabolic-syndrome-affects-narrow-band-uvb-phototherapy-response-in-patients-with-psoriasis
#16
Wang Rui, Ding Xiangyu, Xie Fang, Gong Long, Yang Yi, Wang Wenjuan, Hao Tian, Zhang Xiaoning, Zhou Yong, Fan Jianfeng, Li Hengjin, Li Chengxin
Psoriasis is a chronic inflammatory skin disease. Metabolic syndrome (MS) is a combination of central obesity, dyslipidemia, glucose intolerance, and elevated blood pressure. Many epidemiological surveys have revealed the association of psoriasis with MS. Narrowband ultraviolet radiation b (NB-UVB) is an effective and widely used treatment for psoriasis. The purpose of this study was to investigate whether the presence of MS in patient with psoriasis affects NB-UVB treatment and whether this syndrome correlates with systemic inflammation...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29369396/current-developments-in-phototherapy-for-psoriasis
#17
REVIEW
Akimichi Morita
Phototherapy utilizes the beneficial effects of ultraviolet (UV) wavelengths to affect immunoregulatory functions. UV light phototherapy using narrowband UV-B (NB-UVB) and bath-psoralen UV-A (bath-PUVA) therapy are well-established treatments for psoriasis. Dual-action mechanisms of UV phototherapy have been identified: apoptosis and immune suppression. NB-UVB depletes pathogenic T cells by inducing apoptosis and regulatory T cells. Other wavelengths are also utilized for phototherapy, namely 308-nm excimer light and 312-nm flat-typed NB-UVB...
January 25, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/29349514/nb-uvb-irradiation-downregulates-keratin-17-expression-in-keratinocytes-by-inhibiting-the-erk1-2-and-stat3-signaling-pathways
#18
Yuchen Zhuang, Changxu Han, Bing Li, Liang Jin, Erle Dang, Hui Fang, Hongjiang Qiao, Gang Wang
Keratin-17 (K17) is a cytoskeletal protein produced by keratinocytes (KCs), which is overexpressed in psoriasis and may play a pivotal role in its pathogenesis. Narrow-band ultraviolet B (NB-UVB) irradiation is used as a general treatment for psoriasis, although its impact on K17 expression has yet to be determined. In this study, we aimed to investigate the effect of NB-UVB irradiation on K17 expression and its signaling pathways. After exposure to NB-UVB irradiation, immortalized human keratinocytes (HaCaT cells) were analyzed by flow cytometry, CCK-8 assays and transmission electron microscopy to examine proliferation...
March 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29330859/differential-effects-of-phototherapy-adalimumab-and-betamethasone-calcipotriol-on-effector-and-regulatory-t-cells-in-psoriasis
#19
I S Kotb, B J Lewis, R N Barker, A D Ormerod
BACKGROUND: Psoriasis is a chronic T cell-mediated skin disease with marked social and economic burdens. Current treatments are unsatisfactory, with unpredictable remission times and incompletely understood modes of action. Recent advances in our understanding of the pathogenesis of psoriasis identify the imbalance between CD4+ T effector cells, particularly the T helper (Th) 17 subset, and regulatory T cells (Treg) as key to the development of psoriatic lesions, and therefore a novel therapeutic target...
January 12, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29318595/the-early-repigmentation-pattern-of-vitiligo-is-related-to-the-source-of-melanocytes-and-by-the-choice-of-therapy-a-retrospective-cohort-study
#20
Ke Yang, Xixi Xiong, Gorkhali Pallavi, Yuting Ling, Fei Ding, Weiwei Duan, Weiling Sun, Gaozhong Ding, Qingli Gong, Wenyuan Zhu, Yan Lu
BACKGROUND: Patients with vitiligo present with different repigmentation patterns in the early recovery stage. OBJECTIVES: To analyze the relationships between early repigmentation patterns in vitiliginous patches, their clinical characteristics, and therapeutic choices. METHODS: Patients with vitiligo seen in the Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University from 2010 to 2015, were included, and their clinical records, especially photographs and medical treatments, were reviewed...
March 2018: International Journal of Dermatology
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