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https://www.readbyqxmd.com/read/28771503/narrowband-uvb-treatment-is-highly-effective-and-causes-a-strong-reduction-in-the-use-of-steroid-and-other-creams-in-psoriasis-patients-in-clinical-practice
#1
John Foerster, Kirsty Boswell, Jonathan West, Heather Cameron, Colin Fleming, Sally Ibbotson, Robert Dawe
BACKGROUND: Narrowband NB-UVB phototherapy (NB-UVB) is an effective treatment for psoriasis, as demonstrated by clinical trials. However, due to required infrastructure and need for treatment attendance opinions on the value of offering this treatment in routine practice vary. AIMS: To provide high quality large-scale and long-term data on the efficacy of NB-UVB for psoriasis under real-world conditions in order to assist in management decisions. METHODS: The following resources were employed: (1) complete and prospectively recorded prescription drug records for a population of 420,000 marked by low demographic mobility, (2) prospectively recorded clinical treatment outcomes for all NB-UVB treatment episodes occurring in the local population; (3) complete dermatology electronic treatment records of all psoriasis patients, allowing cross-validation of diagnoses and treatment records...
2017: PloS One
https://www.readbyqxmd.com/read/28748592/influence-of-narrowband-ultraviolet-b-phototherapy-on-serum-tumour-necrosis-factor-like-weak-inducer-of-apoptosis-tweak-in-patients-with-psoriasis
#2
H Myśliwiec, P Kiluk, P Myśliwiec, B Żelazowska-Rutkowska, A Baran, I Flisiak
Psoriasis is characterized by keratinocyte resistance to apoptosis. We recently demonstrated an increase in serum tumour necrosis factor-like weak inducer of apoptosis (TWEAK) in patients after topical treatment for psoriasis. We decided to verify whether narrowband ultraviolet B (NB-UVB) has a similar effect. Serum concentration of TWEAK was estimated in patients with exacerbated plaque psoriasis treated with NB-UVB. Baseline TWEAK levels were similar in patients with psoriasis and healthy controls, and Psoriasis Area and Severity Index (PASI) correlated inversely with TWEAK levels...
July 27, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28748302/effect-of-combination-of-fractional-co2-laser-and-narrow-band-ultraviolet-b-versus-narrow-band-ultraviolet-b-in-the-treatment-of-non-segmental-vitiligo
#3
Mohamed Bakr El-Zawahry, Naglaa Sameh Zaki, Marian Youssry Wissa, Marwah Adly Saleh
The present study was designed to evaluate the effect of combining fractional CO2 laser with narrow-band ultraviolet B (NB-UVB) versus NB-UVB in the treatment of non-segmental vitiligo. The study included 20 patients with non-segmental stable vitiligo. They were divided into two groups. Group I received a single session of fractional CO2 laser therapy on the right side of the body followed by NB-UVB phototherapy twice per week for 8 weeks. Group II received a second session of fractional CO2 laser therapy after 4 weeks from starting treatment with NB-UVB...
July 26, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28718676/selenium-zinc-copper-cu-zn-ratio-and-total-antioxidant-status-in-the-serum-of-vitiligo-patients-treated-by-narrow-band-ultraviolet-b-phototherapy
#4
Marta Wacewicz, Katarzyna Socha, Jolanta Soroczyńska, Marek Niczyporuk, Piotr Aleksiejczuk, Jolanta Ostrowska, Maria H Borawska
BACKGROUND: Vitiligo is a chronic, depigmenting skin disorder, whose pathogenesis is still unknown. Narrow band ultraviolet-B (NB-UVB) is now one of the most widely used treatment of vitiligo. It was suggested that trace elements may play a role in pathogenesis of vitiligo. AIM: The aim of this study was to estimate the concentration of selenium (Se), zinc (Zn), copper (Cu) and Cu/Zn ratio as well as total antioxidant status (TAS) in the serum of patients with vitiligo...
August 1, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28718005/sunscreens-block-cutaneous-vitamin-d-production-with-only-a-minimal-effect-on-circulating-25-hydroxyvitamin-d
#5
Florence Libon, Justine Courtois, Caroline Le Goff, Pierre Lukas, Neus Fabregat-Cabello, Laurence Seidel, Etienne Cavalier, Arjen F Nikkels
A 50+ SPF sunscreen decreased significantly cutaneous vitamin D production following a single narrow-band (nb)UVB exposure, independently from the body surface area exposed. In contrast, the circulating 25(OH)D3 levels were only minimally affected. It is probable that another endogenous source of precursors is selected when skin-originated precursors are lacking. PURPOSE: Sunscreen use, highly advocated for preventing cutaneous carcinogenesis, is potentially leading to an aggravation of vitamin D deficiency with its consequences on bone health...
December 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/28710660/fractional-er-yag-laser-assisting-topical-betamethasone-solution-in-combination-with-nb-uvb-for-resistant-non-segmental-vitiligo
#6
Ru Yan, Jinping Yuan, Hongqiang Chen, Yuan-Hong Li, Yan Wu, Xing-Hua Gao, Hong-Duo Chen
Resistant non-segmental vitiligo is difficult to be treated. Ablative erbium-YAG (Er:YAG) laser has been used in the treatment of vitiligo, but the ablation of entire epidermis frustrated the compliance of patients. The purpose of this study is to investigate the effects of fractional Er:YAG laser followed by topical betamethasone and narrow band ultraviolet B (NB-UVB) therapy in the treatment of resistant non-segmental vitiligo. The vitiligo lesions of each enrolled patient were divided into four treatment parts, which were all irradiated with NB-UVB...
July 14, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28704992/serum-levels-of-tumor-necrosis-factor-alpha-in-patients-with-psoriasis-before-during-and-after-narrow-band-uvb-phototherapy
#7
Maria T Rossi, Marina Venturini, Arianna Zanca, Mariachiara Arisi, Marta Fusano, Alessandra Sottini, Federico Serana, Luisa Imberti, Piergiacomo Calzavara-Pinton
BACKGROUND/PURPOSE: Narrow-band UVB (NB-UVB) phototherapy is widely used worldwide for moderate and severe psoriasis, which is a chronic autoimmune inflammatory disease characterized by skin infiltrates of Th1-, Th17- and Th22-cells releasing locally pro- inflammatory cytokines. We investigate serum levels of tumor necrosis factor-α (TNF-α) in psoriatic patients before and after NB-UVB phototherapy. METHODS: Twenty-eight subjects with moderate/severe plaque type psoriasis were enrolled...
July 11, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28699044/uva1-vs-narrowband-uvb-phototherapy-in-the-treatment-of-palmoplantar-pustulosis-a-pilot-randomized-controlled-study
#8
Li-Na Su, Jie Ren, Shi-Meng Cheng, Jian-Lan Liu, Yang-Feng Ding, Ning-Wen Zhu
UVA1 phototherapy, a new therapeutic approach, has recently been shown good efficacy in the treatment of palmoplantar pustulosis (PPP). The purpose of this study was to compare the efficacy of UVA1 and narrowband UVB (NB-UVB) therapy in the treatment of PPP. Patients with PPP were randomly assigned to either UVA1 or NB-UVB therapy according to a left-right randomization table. Both treatments were performed three times weekly for up to 30 sessions. Clinical evaluation was based on the Palmoplantar Pustular Psoriasis Area and Severity Index (PPPASI) score...
July 11, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28686753/narrowband-uvb-treatment-increases-serum-25-hydroxyvitamin-d-levels-in-patients-with-chronic-plaque-psoriasis
#9
Seyamak Saleky, Isil Bulur, Zeynep N Saraçoğlu
The aim of this study was to investigate the effects of narrowband UVB (NB-UVB) phototherapy on serum 25-hydroxyvitamin D (25[OH]D) levels and related parameters in patients with psoriasis. Forty-nine participants with moderate to severe plaque-type psoriasis were included in this study and were treated with NB-UVB therapy 3 times weekly for 6 months or until psoriasis area and severity index (PASI) 75 was achieved. Participants' serum 25(OH)D, calcium, phosphorus, parathyroid hormone (PTH), and alkaline phosphatase (ALP) levels were measured at baseline and completion of treatment, along with PASI scores...
June 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28632811/management-of-poorly-controlled-indolent-systemic-mastocytosis-using-narrowband-uvb-phototherapy
#10
Zain Husain, Dylan Waterman, Kathleen Ellison, Jennifer A DeSimone
The mastocytoses comprise a group of proliferative stem cell disorders defined by the abnormal accumulation of mast cells (MCs) in the skin or other body tissues including the bone marrow, gastrointestinal tract, and liver. Systemic mastocytosis is defined by the presence of one major and one minor criterion or 3 minor criteria delineated by the World Health Organization (WHO). We present the case of a 57-year-old woman with a 10-year history of red-brown pruritic maculopapular lesions on the upper and lower extremities and trunk who was originally diagnosed with cutaneous mastocytosis...
May 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28587417/a-comparative-study-for-the-short-term-effects-of-targeted-high-intensity-uvb-and-narrow-band-uvb-in-the-treatment-of-vitiligo
#11
Min Zhang, Wei-Yuan Ma
Vitiligo is a common acquired depigmentation disorder for which many treatments have previously been used with varying effects. The aim of the present study was to evaluate the efficacy and safety of targeted high-intensity (TH) and narrow band (NB) ultraviolet B light (UVB) for vitiligo treatment. A total of 33 patients with vitiligo were enrolled in the present study. Patients with a symmetrical or near-symmetrical distribution of lesions on their bodies were selected for the present study. For each patient, half of the body was treated with TH-UVB and the other with NB-UVB twice weekly over a period of 12 weeks (24 times total)...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28494373/influence-of-li-charge-compensator-ion-on-the-energy-transfer-from-pr-3-to-gd-3-ions-in-ca9mg-po4-6f2-gd-3-pr-3-li-phosphor
#12
Sumedha Tamboli, S J Dhoble
Phototherapy is a renowned treatment for curing skin diseases since ancient times. Phototherapeutic treatment for psoriasis and many other diseases require narrow band ultra violet-B (NB-UVB) light with peak intensity at 313nm to be exposed to the affected part of body. In this paper, we report combustion synthesis of NB-UVB -313nm emitting Ca9Mg(PO4)6F2 phosphors doped with Gd(3+), Pr(3+) and Li(+) ions. The phase formation was confirmed by obtaining X-ray diffraction (XRD) pattern and morphology was studied with the Scanning electron microscopy (SEM) images...
May 2, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28445194/successful-treatment-of-stable-vitiligo-by-low-density-cultured-autologous-melanocyte-transplantation-combined-with-narrowband-ultraviolet-b-therapy
#13
Lei Yao, Yuanyuan Liu, Yang Song, Shuxia Zhong, Shanshan Li
BACKGROUND: Cultured autologous melanocyte transplantation (CMT) is an effective treatment for stable vitiligo, but the current method is time consuming and expensive because of the requirement of a large number of melanocytes. OBJECTIVE: To assess the clinical effect of low-density CMT combined with narrowband ultraviolet B (NB-UVB) in treating stable vitiligo. MATERIALS AND METHODS: The authors treated 8 patients with CMT at a low cell density (less than 2...
April 24, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28425237/the-efficacy-of-narrowband-uvb-treatment-in-pediatricvitiligo-a-retrospective-analysis-of-26-cases
#14
Serkan Yazici, Berrin Günay, Emel Bülbül Başkan, Kenan Aydoğan, Hayriye Saricaoğlu, Şükran Tunali
BACKGROUND/AIM: Narrowband UVB (Nb UVB) treatment is commonly used for the management of psoriasis and atopic dermatitis, and is less often used for vitiligo in children. The aim of this study was to evaluate the efficacy and short-term safety of Nb UVB phototherapy in children diagnosed with vitiligo retrospectively. MATERIALS AND METHODS: A total of 26 patients younger than 18 years with the diagnosis of vitiligo and managed with Nb UVB phototherapy as documented in archive records were evaluated...
April 18, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28421233/psoriasis-and-pro-angiogenetic-factor-cd93-gene-expression-and-association-with-gene-polymorphism-suggests-a-role-in-disease-pathogenesis
#15
Albert Duvetorp, Renate Slind Olsen, Marita Skarstedt, Jan Söderman, Oliver Seifert
CD93 is involved in angiogenesis and inflammation, both of which are key processes in the pathogenesis of psoriasis. CD93 was studied in serum, peripheral blood mononuclear cells and skin of patients with psoriasis and controls. Furthermore, allele frequencies for CD93 single-nucleotide polymorphisms rs2749812 and rs2749817 were assessed in patients with psoriasis compared with controls and the effect of narrowband ultraviolet B (NB-UVB) treatment on CD93 gene expression was evaluated in the skin of patients with psoriasis...
April 19, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28217471/disseminate-and-recurrent-infundibulo-folliculitis-in-an-indian-patient-a-case-report-with-review-of-literature
#16
Sukumaran Pradeep Nair, Mini Gomathy, Gopinathan Nanda Kumar
A 17-year-old male patient presented with multiple discrete and confluent monomorphic skin-colored pinhead-sized follicular papules, with occasional pustules distributed on the neck, upper chest, upper posterior trunk, and proximal extremities of 4 months duration. The lesions were asymptomatic, and there was no prior history of topical application or history of atopic dermatitis. Routine investigations were normal. Histopathology of the papules showed a mononuclear infiltrate at the infundibulum of the hair follicle...
January 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/28168735/does-imiquimod-pretreatment-optimize-308-nm-excimer-laser-uvb-therapy-in-psoriasis-patients
#17
Joselin D Tacastacas, Patricia Oyetakin-White, David C Soler, Andrew Young, Sarah Groft, Kord Honda, Kevin D Cooper, Thomas S McCormick
BACKGROUND/PURPOSE: Psoriasis continues to be a debilitating skin disease affecting 1-3% of the United States population. Although the effectiveness of several current biologic therapies have described this pathology as a IL-23, TNF-a and Th17-mediated disease, less invasive approaches are still in use and in need of refinement. One of these is the usage of narrow band-UVB (NB-UVB) therapy to deplete specifically intra-epidermal CD3+, CD4+ and CD8+ cells to clear psoriatic plaques. AIMS/OBJECTIVES: In order to improve NB-UVB therapy, we sought to determine whether skin pre-treatment with the TLR7 agonist imiquimod (IMQ) would help increase the efficiency of the former at resolving psoriatic plaques...
July 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/28111789/treatment-of-adult-diffuse-pityriasis-lichenoides-chronica-with-narrowband-ultraviolet-b-experience-and-literature-review
#18
M Fernández-Guarino, S Aboin-Gonzalez, C Ciudad Blanco, D Velázquez Tarjuelo, P Lázaro Ochayta
Pityriasis lichenoides chronica (PLC) is an infrequent dermatosis of unknown aetiology, wholse evolution and response to treatment differs between children and adults. When PLC is recalcitrant or unresponsive to topical treatment, phototherapy is one of the main treatments used. We carried out a prospective study of adult diffuse PLC treated with narrowband ultraviolet B (NB-UVB). We treated eight patients whose disease showed no response to topical therapy, and obtained a complete response rate of 88% in a mean of 23 sessions (cumulative dose 16...
April 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/27883996/phototherapy-with-narrow-band-uvb-in-adult-guttate-psoriasis-results-and-patient-assessment
#19
Montserrat Fernández-Guarino, Sonsoles Aboín-González, Diana Velázquez, Lucia Barchino, Natividad Cano, Pablo Lázaro
BACKGROUND: Acute guttate psoriasis (AGP) is a distinctive clinical entity with good response to treatment with narrow-band ultraviolet B (NB-UVB). OBJECTIVE: To investigate the results of NB-UVB phototherapy in adult patients with adult guttate psoriasis. MATERIAL AND METHODS: We carried out a prospective, open, and observational study. Patients over 18 years with more than 5% of body surface area affected were included. The PASI was assessed prior to and after treatment...
2016: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/27828628/c-reactive-protein-serum-level-in-patients-with-psoriasis-before-and-after-treatment-with-narrow-band-ultraviolet-b
#20
Mahmoud Farshchian, Akram Ansar, Mohammadreza Sobhan, Valiollah Hoseinpoor
Background: C-reactive protein is an inflammatory biomarker and its level increases in the serum of psoriatic patients. Its level is also associated with Psoriasis Area and Severity Index score. Objective: The aim of this study was to assess the decrement of serum C-reactive protein level with narrow-band ultraviolet B (NB-UVB) therapy. Methods: C-reactive protein serum levels in psoriasis patients were measured before and after treatment with NB-UVB and the data were analyzed in relation to the Psoriasis Area and Severity Index score improvement...
September 2016: Anais Brasileiros de Dermatologia
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