Zizi Yu, Pablo Vieyra-Garcia, Theresa Benezeder, Jack D Crouch, Ira R Kim, John T O'Malley, Phillip M Devlin, Ahmed Gehad, Qian Zhan, Johann E Gudjonsson, Mrinal K Sarkar, J Michelle Kahlenberg, Nega Gerard, Jessica E Teague, Thomas S Kupper, Nicole R LeBoeuf, Cecilia Larocca, Marianne Tawa, Bohdan Pomahac, Simon G Talbot, Dennis P Orgill, Peter Wolf, Rachael A Clark
Transcriptional profiling demonstrated markedly reduced type I interferon gene expression in untreated mycosis fungoides skin lesions compared to healthy skin. Type I interferon expression in MF correlated with APC-associated IRF5 before PUVA and epithelial ULBP2 after therapy, suggesting an enhancement of epithelial type I IFN. Immunostains confirmed reduced baseline type I interferon production in MF and increased levels post-PUVA in responding patients. Effective tumor clearance was associated with increased type I interferon expression, enhanced recruitment of CD8+ T cells into skin lesions and expression of genes associated with antigen specific T cell activation...
September 14, 2023: Journal of Investigative Dermatology