keyword
MENU ▼
Read by QxMD icon Read
search

Uva

keyword
https://www.readbyqxmd.com/read/28535027/arsenite-binds-to-the-ring-finger-domain-of-fancl-e3-ubiquitin-ligase-and-inhibits-dna-interstrand-cross-link-repair
#1
Ji Jiang, Marina Bellani, Lin Li, Pengcheng Wang, Michael M Seidman, Yinsheng Wang
Human exposure to arsenic in drinking water is known to be associated with the development of bladder, lung, kidney, and skin cancers. The molecular mechanisms underlying the carcinogenic effects of arsenic species remain incompletely understood. DNA interstrand cross-links (ICLs) are among the most cytotoxic type of DNA lesions that block DNA replication and transcription, and these lesions can be induced by endogenous metabolism and by exposure to exogenous agents. Fanconi anemia (FA) is a congenital disorder manifested with elevated sensitivity toward DNA interstrand cross-linking agents...
May 23, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28532937/collagen-crosslinking-with-conventional-and-accelerated-ultraviolet-a-irradiation-using-riboflavin-with-hydroxypropyl-methylcellulose
#2
Anne Marie Hagem, Andreas Thorsrud, Gunhild Falleth Sandvik, Marianne Råen, Liv Drolsum
PURPOSE: To evaluate corneal collagen crosslinking (CXL) with conventional and accelerated ultraviolet-A (UVA) irradiation using riboflavin with methylcellulose. SETTING: Department of Ophthalmology, Oslo University Hospital, Oslo, Norway. DESIGN: Prospective randomized case series. METHODS: Patients with keratoconus were randomized to have CXL using conventional 3 mW/cm(2) UVA irradiation for 30 minutes (CXL30) or accelerated 9 mW/cm(2) UVA irradiation for 10 minutes (CXL10)...
April 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28531333/the-flaws-in-the-detail-of-an-observational-study-on-transcatheter-aortic-valve-implantation-versus-surgical-aortic-valve-replacement-in-intermediate-risks-patients
#3
Fabio Barili, Nick Freemantle, Thierry Folliguet, Claudio Muneretto, Michele De Bonis, Martin Czerny, Jean Francois Obadia, Nawwar Al-Attar, Nikolaos Bonaros, Jolanda Kluin, Roberto Lorusso, Prakash Punjabi, Rafael Sadaba, Piotr Suwalski, Umberto Benedetto, Andreas Böning, Volkmar Falk, Miguel Sousa-Uva, Pieter A Kappetein, Lorenzo Menicanti
The PARTNER group recently published a comparison between the latest generation SAPIEN 3 transcatheter aortic valve implantation (TAVI) system (Edwards Lifesciences, Irvine, CA, USA) and surgical aortic valve replacement (SAVR) in intermediate-risk patients, apparently demonstrating superiority of the TAVI and suggesting that TAVI might be the preferred treatment method in this risk class of patients. Nonetheless, assessment of the non-randomized methodology used in this comparison reveals challenges that should be addressed in order to elucidate the validity of the results...
June 1, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28513644/light-induced-cytotoxicity-of-nitrofurantoin-toward-murine-melanoma
#4
Lucimara P Ferreira, Gustavo G Parra, Débora C K Codognato, André M Amado, Roberto S da Silva
The cytotoxicity of nitrofurantoin (NFT) in the dark and after light exposure (UVA irradiation, λ = 385 nm) was evaluated in murine melanoma B16F10 cells. NFT induces both cell proliferation and inhibition of cell viability. The dominance of one or the other effect depends on the drug concentration, incubation time (tinc) and irradiation dose. The uptake of NFT in these cells, as well as its photocytotoxicity, reaches saturation after 24 hours of incubation. The mechanism of cell death in the dark is associated with the enzymatic release of nitric oxide (NO)...
May 17, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/28512459/in-vivo-chronic-stimulation-unveils-autoreactive-potential-of-wiskott-aldrich-syndrome-protein-deficient-b-cells
#5
Maria Carmina Castiello, Francesca Pala, Lucia Sereni, Elena Draghici, Donato Inverso, Aisha V Sauer, Francesca Schena, Elena Fontana, Enrico Radaelli, Paolo Uva, Karla E Cervantes-Luevano, Federica Benvenuti, Pietro L Poliani, Matteo Iannacone, Elisabetta Traggiai, Anna Villa, Marita Bosticardo
Wiskott-Aldrich syndrome (WAS) is a primary immunodeficiency caused by mutations in the gene encoding the hematopoietic-specific WAS protein (WASp). WAS is frequently associated with autoimmunity, indicating a critical role of WASp in maintenance of tolerance. The role of B cells in the induction of autoreactive immune responses in WAS has been investigated in several settings, but the mechanisms leading to the development of autoimmune manifestations have been difficult to evaluate in the mouse models of the disease that do not spontaneously develop autoimmunity...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28501886/rhinophototherapy-in-chronic-rhinosinusitis-a-double-blind-randomized-placebo-controlled-trial
#6
N Dulguerov, N Guinand, D Courvoisier, B N Landis, J S Lacroix, C Hauser
BACKGROUND: This study evaluated the efficacy of rhinophototherapy in patients with chronic rhinosinusitis (CRS) without nasal polyps. METHOD: In this randomized double-blind, placebo-controlled trial, CRS patients (n=50) received either mixed visible and ultraviolet (UVA and UVB) light source application (mUV/VIS) or visible light alone that served as placebo. Both groups were treated for 3 weeks. RESULTS: Results in the rhinophototherapy and placebo group were not significantly different and failed to reduce patient-reported outcomes measures (Rhinosinusits Disability Index, Visual Analogic Scale of symptom severity) and objective scores (rhinomanometry, olfactory thresholds, nasal Nitic Oxide concentrations), immediately and one month after treatment...
May 14, 2017: Rhinology
https://www.readbyqxmd.com/read/28501563/kindlin-1-protects-cells-from-oxidative-damage-through-activation-of-erk-signalling
#7
Hila Emmert, Hitesh Patel, Valerie G Brunton
Kindlin-1 is a FERM domain containing adaptor protein that is found predominantly at cell-extracellular matrix adhesions where it binds to β-integrin subunits and is required for integrin activation. Loss of function mutations in the FERMT1 gene which encodes Kindlin-1 leads to the development of Kindler Syndrome (KS) an autosomal recessive skin disorder characterized by skin blistering, photosensitivity, and predisposition to aggressive squamous cell carcinoma (SCC). Here we show that loss of Kindlin-1 sensitizes both SCC cells and keratinocytes to oxidative stress: Kindlin-1 deficient cells have higher levels of reactive oxygen species, decreased viability and increased DNA damage after treatment with either hydrogen peroxide (H2O2) or irradiation with UVA...
May 10, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28500968/stability-and-removal-of-selected-avobenzone-s-chlorination-products
#8
Cheng Wang, Mojca Bavcon Kralj, Berta Košmrlj, Jun Yao, Suzana Košenina, Olga V Polyakova, Viatcheslav B Artaev, Albert T Lebedev, Polonca Trebše
Stability studies of two avobenzone transformation products: chloro-avobenzone [2-chloro-1-(4-tert-butylphenyl)-3-(4-methoxyphenyl)-1,3-propanedione] and dichloro-avobenzone [2,2-dichloro-1-(4-tert-butylphenyl)-3-(4-methoxyphenyl)-1,3-propanedione] have been performed at different pHs values as well as under UV A light and compared with the stability of avobenzone, one of the mostly used UV A filter present in sunscreens. We have additionally investigated the possibility of application of TiO2 photocatalysis as a method for the removal of them...
May 6, 2017: Chemosphere
https://www.readbyqxmd.com/read/28500276/while-reinforcing-cell-cycle-arrest-rapamycin-and-torins-suppress-senescence-in-uva-irradiated-fibroblasts
#9
Olga V Leontieva, Mikhail V Blagosklonny
Sunlight predisposes to skin cancer and melanomas. Ultraviolet A (UVA), a long wave component of sunlight, can reach dermal fibroblasts. Here we studied UVA-induced senescence in human fibroblasts in vitro. It is known that senescence occurs, when cell cycle is arrested, but mTOR is still active, thus converting arrest to senescence (geroconversion). We showed that, while arresting cell cycle, UVA did not inhibit mTOR, enabling geroconversion. In UVA-treated cells, mTOR remained fully active. Rapamycin and Torins 1/ 2 prevented UVA-induced senescent phenotype, although they further re-enforced cell cycle arrest...
May 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28498430/uva-induced-upregulation-of-progerin-suppresses-53bp1%C3%A2-mediated-nhej-dsb-repair-in-human-keratinocytes-via-progerin-lamin%C3%A2-a-complex-formation
#10
Xin Huang, Yun Pan, Di Cao, Sheng Fang, Kun Huang, Jin Chen, Aijun Chen
Ultraviolet (UV) radiation is the primary risk factor underlying photoaging and photocarcinogenesis. Mounting research has focused on the role of DNA damage response pathways in UV-induced double-strand break (DSB) repair. In the present study, we hypothesized that UVA-induced aberrant progerin upregulation may adversely affect p53-binding protein 1 (53BP1)-mediated non-homologous end joining (NHE) DSB repair in human keratinocytes. Basal cell carcinoma (BCC) tumors and matching normal skin tissue were sampled (n=200) to investigate whether human keratinocytes display dysregulated progerin expression as a function of advancing age and BCC status...
April 26, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28494427/on-line-detection-of-escherichia-coli-intrusion-in-a-pilot-scale-drinking-water-distribution-system
#11
Jenni Ikonen, Tarja Pitkänen, Pascal Kosse, Robert Ciszek, Mikko Kolehmainen, Ilkka T Miettinen
Improvements in microbial drinking water quality monitoring are needed for the better control of drinking water distribution systems and for public health protection. Conventional water quality monitoring programmes are not always able to detect a microbial contamination of drinking water. In the drinking water production chain, in addition to the vulnerability of source waters, the distribution networks are prone to contamination. In this study, a pilot-scale drinking-water distribution network with an on-line monitoring system was utilized for detecting bacterial intrusion...
May 8, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28486315/comparison-of-2-different-methods-of-transepithelial-corneal-collagen-cross-linking-analysis-of-corneal-histology-and-hysteresis
#12
Young Min Park, Ho Yoon Kim, Jong Soo Lee
PURPOSE: To compare the effect of 2 different methods of transepithelial corneal collagen cross-linking (CXL) on corneal histology and hysteresis. METHODS: The right eyes of New Zealand white rabbits (n = 50) were treated using one of the 2 transepithelial CXL methods. The eyes were then divided into 2 groups: group 1, transepithelial CXL using continuous ultraviolet A (UVA); group 2, accelerated transepithelial CXL using pulsed UVA. RESULTS: Both groups showed a postoperative increase in central corneal thickness...
May 8, 2017: Cornea
https://www.readbyqxmd.com/read/28482225/immunostaining-of-uva-induced-dna-damage-in-erythrocytes-of-medaka-oryzias-latipes
#13
Alaa El-Din Hamid Sayed, Hiroshi Mitani
Some authors have recently reported that UVA induces double-strand breaks (DSBs) in DNA. Only a few researchers have reported on the induction of DSBs upon UVA exposure, as measured using the Comet assay and γ-H2AX as markers of DSB formation. In the present study, we have investigated for the first time the dose-dependent induction of DSBs by UVA in medaka (Oryzias latipes) erythrocytes. Adult female medaka fish were exposed to UVA for 15, 30, and 60min/day for three continuous days; an unirradiated control group was kept in the same laboratory conditions...
April 28, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28477073/-riboflavin-uva-crosslinking-in-progressive-keratoconus
#14
P Maier, T Reinhard
In patients with keratoconus, a progressive, ectatic disease of the cornea, the shape of the cornea is continuously changing leading to a reduction in visual acuity by progressive myopia and more and more (irregular) astigmatism. The symptomatic treatment consists of the prescription of glasses or special gas-permeable rigid contact lenses. Corneal tomography is generally used for diagnosis. After initial diagnosis of keratoconus, regular tomographic follow-ups should be performed. If clinically significant progression is found and confirmed by repeated measurements, riboflavin UVA collagen crosslinking should be offered to the patients...
May 5, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28476435/a-multi-institutional-analysis-of-trimodality-therapy-for-esophageal-cancer-in-elderly-patients
#15
Scott C Lester, Steven H Lin, Michael Chuong, Neha Bhooshan, Zhongxing Liao, Andrea L Arnett, Sarah E James, Jaden D Evans, Grant M Spears, Ritsuko Komaki, Michael G Haddock, Minesh P Mehta, Christopher L Hallemeier, Kenneth W Merrell
PURPOSE: The therapeutic gains of neoadjuvant chemoradiation therapy (nCRT) followed by esophagectomy may be offset by increased incidences of morbidity and mortality in elderly patients. This study aimed to determine the impact of age on the risks and benefits of trimodality therapy for esophageal cancer. METHODS AND MATERIALS: We evaluated 571 patients treated with trimodality therapy at 3 high-volume tertiary cancer centers in the United States from 2007 to 2013...
February 20, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28475964/electrochemical-advanced-oxidation-processes-for-staphylococcus-aureus-disinfection-in-municipal-wwtp-effluents
#16
Pilar Valero, Martha Verbel, Javier Silva-Agredo, Rosa Mosteo, Maria P Ormad, Ricardo A Torres-Palma
This paper presents the Staphylococcus aureus inactivation in a simulated wastewater treatment plant effluent by different electrochemical techniques, including the photo-electro-Fenton process. S. aureus, dissolved organic carbon (DOC), total oxidants and H2O2 concentrations, as well as pH, were monitored during the assays. An electrolytic cell, including a UVA lamp, a gas diffusion electrode (GDE) as cathode and an IrO2 anode, was used to conduct the experiments under galvanostatic conditions (20 mA). Low inactivation (-0...
May 2, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28472484/adverse-events-while-awaiting-myocardial-revascularization-a-systematic-review-and-meta-analysis
#17
Stuart J Head, Bruno R da Costa, Berend Beumer, Giulio G Stefanini, Fernando Alfonso, Peter M Clemmensen, Jean-Philippe Collet, Jochen Cremer, Volkmar Falk, Gerasimos Filippatos, Christian Hamm, A Pieter Kappetein, Adnan Kastrati, Juhani Knuuti, Philippe Kolh, Ulf Landmesser, Günther Laufer, Franz-Josef Neumann, Dimitrios J Richter, Patrick Schauerte, David P Taggart, Lucia Torracca, Marco Valgimigli, William Wijns, Adam Witkowski, Stephan Windecker, Peter Jüni, Miguel Sousa-Uva
OBJECTIVES: The aim of the current study was to estimate adverse event rates while awaiting myocardial revascularization and review criteria for prioritizing patients. METHODS: A PubMed search was performed on 19 January 2015, to identify English-language, original, observational studies reporting adverse events while awaiting coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI). Rates of death, non-fatal myocardial infarction (MI) and emergency revascularization were calculated as occurrence rates per 1000 patient-weeks and pooled using random-effects models...
May 2, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28470657/-morphologic-corneal-changes-after-crosslinking-for-keratoconus
#18
P L Müller, K U Löffler, M Kohlhaas, F G Holz, M C Herwig-Carl
Keratoconus is a relatively common (1 : 2000) bilateral disease leading to a change in biochemical and biomechanical corneal structure as well as thinning and ectasia. For more than 10 years, crosslinking has been a therapeutic option in cases of progression. Using riboflavin and UVA-radiation, the anterior corneal stroma (300 µm) gets stiffened by crosslinking of collagen fibers. When protocols and limitations are adhered, the procedure is described to be effective and of low-risk. This review gives an overview about physiologic and pathologic changes in keratoconic corneas before and after crosslinking...
May 3, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28463781/visible-and-uva-light-as-a-potential-means-of-preventing-escherichia-coli-biofilm-formation-in-urine-and-on-materials-used-in-urethral-catheters
#19
T L Vollmerhausen, A Conneely, C Bennett, V E Wagner, J C Victor, C P O'Byrne
Catheter-associated urinary tract infections are the most common hospital-acquired infection, for which Escherichia coli is the leading cause. This study investigated the efficacy of 385nm and 420nm light for inactivation of E. coli attached to the silicone matrix of a urinary catheter. Using urine mucin media, inactivation of planktonic bacteria and biofilm formation was monitored using silicone coupons. Continuous irradiance with both 385nm and 420nm wavelengths with starting cell density population 10(3)CFU ml(-1) reduced planktonic suspensions of E...
April 22, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28456119/theoretical-insights-on-flavanones-as-antioxidants-and-uv-filters-a-tddft-and-nlmo-study
#20
P Ajmala Shireen, V M Abdul Mujeeb, K Muraleedharan
UV radiations can cause several irritations to the skin like sunburn, photo aging and even skin cancer. Sunscreens are widely used to protect the skin against these harmful radiations. One of the ingredients present in these sunscreens are organic molecules capable of absorbing these harmful radiations. Recently, the search is on for antioxidant molecules which can act as UV filters as they can facilitate photo protection. In this study, a computational investigation based on density functional theory (DFT) is attempted on flavanones namely pinocembrin, pinostrobin and alpinetin found in Boesenbergia pandurata...
April 20, 2017: Journal of Photochemistry and Photobiology. B, Biology
keyword
keyword
102207
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"