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https://www.readbyqxmd.com/read/28646091/stress-specific-p38-map-kinase-activation-is-sufficient-to-drive-egf-receptor-endocytosis-but-not-nuclear-translocation
#1
Alejandra Tomas, Sylwia Jones, Simon O Vaughan, Daniel Hochhauser, Clare E Futter
P38 MAP kinase-dependent EGF receptor (EGFR) endocytosis is induced by stress. Ligand and stresses like X-rays, reportedly promote nuclear traffic of endocytosed EGFR for regulation of gene transcription and DNA repair. We fail to detect EGFR endocytosis or nuclear transport following X-ray treatment of HeLa or head and neck cancer cells, despite extensive DNA damage induction. Apparent nuclear staining with EGFR extracellular domain antibody remained present despite reduced/absent EGFR expression and so did not represent nuclear EGFR...
June 23, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28644862/high-intensity-corneal-collagen-crosslinking-with-riboflavin-and-uva-in-rat-cornea
#2
Yirui Zhu, Peter S Reinach, Hanlei Zhu, Qiufan Tan, Qinxiang Zheng, Jia Qu, Wei Chen
Corneal collagen cross-linking (CXL) halts human corneal ectasias progression by increasing stromal mechanical stiffness. Although some reports describe that this procedure is effective in dealing with some infectious and immunologic corneal thinning diseases, there is a need for more animal models whose corneal thickness more closely resemble those occurring in these patients. To meet this need, we describe here high-intensity protocols that are safe and effective for obtaining CXL in rat corneas. Initially, a range of potentially effective UVA doses were evaluated based on their effectiveness in increasing tissue enzymatic resistance to dissolution...
2017: PloS One
https://www.readbyqxmd.com/read/28640603/changes-in-light-absorptivity-of-molecular-weight-separated-brown-carbon-due-to-photolytic-aging
#3
Jenny Pui Shan Wong, Athanasios Nenes, Rodney J Weber
Brown carbon (BrC) are those organic compounds in atmospheric aerosols that absorb solar radiation and may play an important role on planetary radiative forcing and climate. However, little is known about the production and loss mechanisms of BrC in the atmosphere. Here, we study how the light absorptivity of BrC from wood smoke and secondary BrC generated from reaction of ammonium sulfate with methylglyoxal changes under photolytic aging by UVA radiation in the aqueous phase. Owing to its chemical complexity, BrC is separated by molecular weight using size exclusion chromatography and the response of each molecular weight fraction to aging is studied...
June 22, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28637558/travel-time-influences-readmission-risk-geospatial-mapping-of-surgical-readmissions
#4
Florence E Turrentine, Patrick J Buckley, Min-Woong Sohn, Michael D Williams
The University of Virginia (UVA) has recently become an Accountable Care Organization (ACO), intensifying efforts to provide better care for individuals. UVA's ACO population resides across the entire Commonwealth, with a large percentage of patients living in rural areas. To provide better health for this population, the central tenet of the ACO mission, we identified geographic risk factors influencing hospital readmission. We analyzed the relationship between the distance of patients' residence to the nearest hospital and 30-day readmission in general surgery patients...
June 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28636748/e-cadherin-mediates-uvr-and-calcium-induced-melanin-transfer-in-human-skin-cells
#5
Suman K Singh, Richard Baker, Stephen K Sikkink, Carine Nizard, Sylvianne Schnebert, Robin Kurfurst, Desmond J Tobin
Skin pigmentation is directed by epidermal-melanin units, characterized by long-lived and dendritic epidermal melanocytes (MC) that interact with viable keratinocytes (KC) to contribute melanin to the epidermis. Previously we reported that MC:KC contact is required for melanosome transfer, that this can be enhanced by filopodial and by UVR/UVA irradiation, which can up-regulate melanosome transfer via Myosin X-mediated control of MC filopodia. Both MC and KC express Ca(2+) -dependent E-cadherins. These homophilic adhesion contacts induce transient increases in intra-KC Ca(2+) , while ultraviolet radiation (UVR) raises intra-MC Ca(2+) via calcium selective ORAI1 ion channels; both are associated with regulating melanogenesis...
June 21, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28628879/development-of-a-method-for-the-characterization-and-operation-of-uv-led-for-water-treatment
#6
Ataollah Kheyrandish, Madjid Mohseni, Fariborz Taghipour
Tremendous improvements in semiconductor technology have made ultraviolet light-emitting diodes (UV-LEDs) a viable alternative to conventional UV sources for water treatment. A robust and validated experimental protocol for studying the kinetics of microorganism inactivation is key to the further development of UV-LEDs for water treatment. This study proposes a protocol to operate UV-LEDs and control their output as a polychromatic radiation source. In order to systematically develop this protocol, the results of spectral power distribution, radiation profile, and radiant power measurements of a variety of UV-LEDs are presented...
June 6, 2017: Water Research
https://www.readbyqxmd.com/read/28627622/human-amnion-derived-mesenchymal-stem-cells-protect-against-uva-irradiation-induced-human-dermal-fibroblast-senescence-in%C3%A2-vitro
#7
Chunli Zhang, Haishen Yuchi, Lu Sun, Xiaoli Zhou, Jinde Lin
The aim of the present study was to determine if human amnion‑derived mesenchymal stem cells (HAMSCs) exert a protective effect on ultraviolet A (UVA) irradiation-induced human dermal fibroblast (HDF) senescence. A senescence model was constructed as follows: HDFs (104‑106 cells/well) were cultured in a six‑well plate in vitro and then exposed to UVA irradiation at 9 J/cm2 for 30 min. Following the irradiation period, HDFs were co‑cultured with HAMSCs, which were seeded on transwells. A total of 72 h following the co‑culturing, senescence‑associated β‑galactosidase staining was performed and reactive oxygen species (ROS) content and mitochondrial membrane potential (Δψm) were detected in the HDFs via flow cytometric analysis...
June 15, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28627461/8-methoxypsoralen-reduces-akt-phosphorylation-induces-intrinsic-and-extrinsic-apoptotic-pathways-and-suppresses-cell-growth-of-sk-n-as-neuroblastoma-and-sw620-metastatic-colon-cancer-cells
#8
Magdalena Bartnik, Adrianna Sławińska-Brych, Aleksandra Żurek, Martyna Kandefer-Szerszeń, Barbara Zdzisińska
ETHNOPHARMACOLOGICAL RELEVANCE: 8-methoxypsoralen (8-MOP) is a furanocoumarin and an active compound of a traditional Egyptian medicinal plant Ammi majus L, whose juice/fruit has been used for many years in folk phototherapy for the treatment of vitiligo or a hyperproliferative skin disorder, psoriasis. 8-MOP together with UVA light is also used as an anticancer drug for the treatment of cutaneous T-cell lymphoma. However, furanocoumarins exert anticancer activity even without UV irradiation...
June 13, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28620751/impact-of-a-rectal-and-bladder-preparation-protocol-on-prostate-cancer-outcome-in-patients-treated-with-external-beam-radiotherapy
#9
A Maggio, D Gabriele, E Garibaldi, S Bresciani, E Delmastro, A Di Dia, A Miranti, M Poli, T Varetto, M Stasi, P Gabriele
PURPOSE AND OBJECTIVE: To test the hypothesis that a rectal and bladder preparation protocol is associated with an increase in prostate cancer specific survival (PCSS), clinical disease free survival (CDFS) and biochemical disease free survival (BDFS). PATIENTS AND METHODS: From 1999 to 2012, 1080 prostate cancer (PCa) patients were treated with three-dimensional conformal radiotherapy (3DCRT). Of these patients, 761 were treated with an empty rectum and comfortably full bladder (RBP) preparation protocol, while for 319 patients no rectal/bladder preparation (NRBP) protocol was adopted...
June 15, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28620706/complete-corneal-ring-myoring-implantation-versus-myoring-implantation-combined-with-corneal-collagen-crosslinking-for-keratoconus-3-year-follow-up
#10
Guzel Bikbova, Gyulli Kazakbaeva, Mukharram Bikbov, Emin Usubov
PURPOSE: To estimate the effectiveness of complete corneal ring (MyoRing) implantation compared with MyoRing implantation combined with corneal collagen crosslinking (CXL) for keratoconus treatment for 36 months follow-up. DESIGN: Retrospective cohort study. MATERIALS AND METHODS: MyoRing implantation was performed in a series of 78 patients (80 eyes) with keratoconus II-III Amsler classification, of these 39 eyes had MyoRing implantation combined with CXL...
June 15, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28619534/cryptochrome-photoreceptors-in-green-algae-unexpected-versatility-of-mechanisms-and-functions
#11
Tilman Kottke, Sabine Oldemeyer, Sandra Wenzel, Yong Zou, Maria Mittag
Green algae have a highly complex and diverse set of cryptochrome photoreceptor candidates including members of the following subfamilies: plant, plant-like, animal-like, DASH and cryptochrome photolyase family 1 (CPF1). While some green algae encode most or all of them, others lack certain members. Here we present an overview about functional analyses of so far investigated cryptochrome photoreceptors from the green algae Chlamydomonas reinhardtii (plant and animal-like cryptochromes) and Ostreococcus tauri (CPF1) with regard to their biological significance and spectroscopic properties...
May 31, 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/28617829/rhythmic-syllable-related-activity-in-a-songbird-motor-thalamic-nucleus-necessary-for-learned-vocalizations
#12
Husain H Danish, Dmitriy Aronov, Michale S Fee
Birdsong is a complex behavior that exhibits hierarchical organization. While the representation of singing behavior and its hierarchical organization has been studied in some detail in avian cortical premotor circuits, our understanding of the role of the thalamus in adult birdsong is incomplete. Using a combination of behavioral and electrophysiological studies, we seek to expand on earlier work showing that the thalamic nucleus Uvaeformis (Uva) is necessary for the production of stereotyped, adult song in zebra finch (Taeniopygia guttata)...
2017: PloS One
https://www.readbyqxmd.com/read/28613256/strawberry-based-cosmetic-formulations-protect-human-dermal-fibroblasts-against-uva-induced-damage
#13
Massimiliano Gasparrini, Tamara Y Forbes-Hernandez, Sadia Afrin, Patricia Reboredo-Rodriguez, Danila Cianciosi, Bruno Mezzetti, Josè L Quiles, Stefano Bompadre, Maurizio Battino, Francesca Giampieri
Extreme exposure of skin to Ultraviolet A (UVA)-radiation may induce a dysregulated production of reactive oxygen species (ROS) which can interact with cellular biomolecules leading to oxidative stress, inflammation, DNA damage, and alteration of cellular molecular pathways, responsible for skin photoaging, hyperplasia, erythema, and cancer. For these reasons, the use of dietary natural bioactive compounds with remarkable antioxidant activity could be a strategic tool to counteract these UVA-radiation-caused deleterious effects...
June 14, 2017: Nutrients
https://www.readbyqxmd.com/read/28607603/photodynamic-treatment-of-oral-squamous-cell-carcinoma-cells-with-low-curcumin-concentrations
#14
Kim Beyer, Frangis Nikfarjam, Manuel Butting, Markus Meissner, Anke König, Ana Ramirez Bosca, Roland Kaufmann, Detlef Heidemann, August Bernd, Stefan Kippenberger, Nadja Zöller
Objective: Curcumin is known for its anti-oxidative, anti-inflammatory and anti-tumorigenic qualities at concentrations ranging from 3.7µg/ml to 55µg/ml. Therefore it is pre-destined for tumour therapy. Due to high oral doses that have to be administered and the low bioavailability of curcumin new therapy concepts have to be developed. One of these therapy concepts is the combination of low curcumin concentrations and UVA or visible light. Aim of our study was to investigate the influence of this treatment regime on oral squamous cell carcinoma cells...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28605402/sparse-redundancy-analysis-of-high-dimensional-genetic-and-genomic-data
#15
Attila Csala, Frans P J M Voorbraak, Aeilko H Zwinderman, Michel H Hof
Motivation: Recent technological developments have enabled the possibility of genetic and genomic integrated data analysis approaches, where multiple omics data sets from various biological levels are combined and used to describe (disease) phenotypic variations. The main goal is to explain and ultimately predict phenotypic variations by understanding their genetic basis and the interaction of the associated genetic factors. Therefore, understanding the underlying geneticmechanisms of phenotypic variations is an ever increasing research interest in biomedical sciences...
June 12, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28604903/antiproliferative-activity-of-8-methoxypsoralen-on-du145-prostate-cancer-cells-under-uva-and-blue-light
#16
Giulio Sturaro, Giulia Cigolini, Luca Menilli, Fabio Cola, Rosa Di Liddo, Alessia Tasso, Maria Teresa Conconi, Giorgia Miolo
The use of photoactivatable 8-methoxypsoralen (8-MOP) as potential focal treatment towards prostate cancer cells is proposed here. Our results, obtained on isolated DNA and DU145 cells, indicate that blue light, besides UVA, is able to activate 8-MOP. When compared to UVA, blue light irradiation led to a modulation of the extent and the types of 8-MOP-DNA damage, specially cross-links, coupled to a still valuable antiproliferative effect. Our data suggest that the proapototic activity of 8-MOP is related not only to DNA damage and reactive oxygen species generation but also to the modulation of cell signalling pathways...
June 12, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/28602332/assessment-of-stromal-riboflavin-concentration-depth-profile-in-nanotechnology-based-transepithelial-corneal-crosslinking
#17
Giuseppe Lombardo, Norberto Liborio Micali, Valentina Villari, Nancy Leone, Sebastiano Serrao, Dario Rusciano, Marco Lombardo
PURPOSE: To determine the intrastromal concentration of riboflavin in nanotechnology-based transepithelial corneal crosslinking. SETTING: Consiglio Nazionale delle Ricerche, Messina, Italy. DESIGN: Experimental study. METHODS: Six human donor sclerocorneal tissues were used to evaluate penetration of nanotechnology-based riboflavin 0.1% solution in the stroma through the intact epithelium. Three additional tissues were deepithelialized and soaked with dextran 20...
May 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28599356/an-in-vitro-model-for-fibroblast-photoaging-comparing-single-and-repeated-uva-irradiations
#18
Wongnapa Nakyai, Aurasorn Saraphanchotiwitthaya, Celine Viennet, Philippe Humbert, Jarupa Viyoch
The current method for efficient evaluation of anti-photoaging compounds is an in vitro skin culture model using a single ultraviolet A (UVA) irradiation of fibroblasts. However, skin photoaging is caused by repeated exposure to UVA radiation. The objective of this study was to develop an appropriate model for in vitro skin photoaging by comparing the different effects of single (5 J/cm(2) ) and repeated exposures (5 J/cm(2) x 3 times) of fibroblasts to UVA irradiation. Our results demonstrated that a single and repeated exposure to UVA irradiation had different effects on fibroblasts...
June 9, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/28593645/ultraviolet-a-photosensitivity-profile-of-dexchlorpheniramine-maleate-and-promethazine-based-creams-anti-inflammatory-antihistaminic-and-skin-barrier-protection-properties
#19
Gustavo Facchini, Samara Eberlin, Stefano Piatto Clerici, Ana Lucia Tabarini Alves Pinheiro, Adilson Costa
BACKGROUND: Unwanted side effects such as dryness, hypersensitivity, and cutaneous photosensitivity are challenge for adherence and therapeutical success for patients using treatments for inflammatory and allergic skin response. AIMS: In this study, we compared the effects of two dermatological formulations, which are used in inflammatory and/or allergic skin conditions: dexchlorpheniramine maleate (DCP; 10 mg/g) and promethazine (PTZ; 20 mg/g). METHODS: We evaluated both formulations for phototoxicity potential, skin irritation, anti-inflammatory and antihistaminic abilities, and skin barrier repair in vitro and ex vivo using the standard OECD test guideline n° 432, the ECVAM protocol n° 78, and cultured skin explants from a healthy patient...
June 7, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28569076/clinical-impact-of-blood-glucose-monitoring-accuracy-an-in-silico-study
#20
Enrique Campos-Náñez, Kurt Fortwaengler, Marc D Breton
BACKGROUND: Patients with diabetes rely on blood glucose (BG) monitoring devices to manage their condition. As some self-monitoring devices are becoming more and more accurate, it becomes critical to understand the relationship between system accuracy and clinical outcomes, and the potential benefits of analytical accuracy. METHODS: We conducted a 30-day in-silico study in type 1 diabetes mellitus (T1DM) patients using continuous subcutaneous insulin infusion (CSII) therapy and a variety of BG meters, using the FDA-approved University of Virginia (UVA)/Padova Type 1 Simulator...
May 1, 2017: Journal of Diabetes Science and Technology
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