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https://www.readbyqxmd.com/read/27926752/corneal-resistance-to-keratolysis-after-collagen-crosslinking-with-rose-bengal-and-green-light
#1
Ali Fadlallah, Hong Zhu, Samer Arafat, Irene Kochevar, Samir Melki, Joseph B Ciolino
Purpose: The purpose of this study was to evaluate the resistance to degradation by collagenase A of corneas that have been crosslinked with Rose Bengal and green light (RGX). Methods: The ex vivo crosslinking procedure was performed on enucleated rabbit corneas. Corneas were deepithelialized after applying 30% alcohol. Corneas were stained with Rose Bengal (RB, 0.1%) for 2 minutes and then exposed to green light (532 nm) at 0.25 W/cm2 for times to deliver doses of 50, 100, 150, or 200 J/cm2 (n = 5 per group)...
December 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27924329/low-cost-uva-led-as-a-radiation-source-for-the-photo-fenton-process-a-new-approach-for-micropollutant-removal-from-urban-wastewater
#2
I de la Obra, B Esteban García, J L García Sánchez, J L Casas López, J A Sánchez Pérez
Light Emitting Diode (LED) technology has matured sufficiently to be considered as an alternative UVA radiation source in photoreactors. Currently, low energy consuming LEDs with a wide range of wavelengths and radiant flux are readily available. In this study, UVA-LEDs were used as a radiation source for the photo-Fenton process as tertiary treatment. The water matrix used was a simulated secondary effluent doped with 200 μg L(-1) of the pesticide acetamiprid (ACTM) due to its recalcitrant nature. All experiments were carried out in a LED-box reactor at pH 2...
December 7, 2016: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/27921413/short-time-efficiency-of-rhinophototherapy-in-management-of-patients-with-allergic-rhinitis-resistant-to-medical-therapy
#3
Soheila Alyasin, Seyed Hesamedin Nabavizadeh, Hamidreza Houshmand, Hossein Esmaeilzadeh, Sina Jelodar, Reza Amin
Allergic rhinitis is one of the most common health problems with a major effect on the quality of life. We intended to treat Allergic Rhinitis (AR) in patients who are either unresponsive to antihistamines or their job requires optimal alertness that may be disturbed by antihistamine's side effects and those who do not comply with the regular use. We tried short term phototherapy and evaluated its effect on AR. As phototherapy is effective in the treatment of atopic dermatitis (AD) and the same allergens can produce both AD and AR, phototherapy is proposed as a new tool in the AR treatment...
August 2016: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/27920763/microbial-activity-response-to-solar-radiation-across-contrasting-environmental-conditions-in-salar-de-huasco-northern-chilean-altiplano
#4
Klaudia L Hernández, Beatriz Yannicelli, Lasse M Olsen, Cristina Dorador, Eduardo J Menschel, Verónica Molina, Francisco Remonsellez, Martha B Hengst, Wade H Jeffrey
In high altitude environments, extreme levels of solar radiation and important differences of ionic concentrations over narrow spatial scales may modulate microbial activity. In Salar de Huasco, a high-altitude wetland in the Andean mountains, the high diversity of microbial communities has been characterized and associated with strong environmental variability. Communities that differed in light history and environmental conditions, such as nutrient concentrations and salinity from different spatial locations, were assessed for bacterial secondary production (BSP, (3)H-leucine incorporation) response from short-term exposures to solar radiation...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27914659/corneal-collagen-cross-linking-a-review-of-its-clinical-applications
#5
K Balparda, M J Maldonado
OBJECTIVE: To perform a literature review of the current clinical applications of corneal collagen cross-linking. METHODS: An exhaustive literature search was made, including the main biomedical databases, and encompassing all years since the introduction of cross-linking in ophthalmology practice. RESULTS: Corneal collagen cross-linking using UVA irradiation and riboflavin is a surgical technique that is currently being optimised, and is supported by a good amount of pre-clinical and clinical studies...
November 30, 2016: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/27911037/decoding-the-molecular-basis-for-the-population-mechanism-of-the-triplet-phototoxic-precursors-in-uva-light-activated-pyrimidine-anticancer-drugs
#6
Lara Martínez-Fernández, Giovanni Granucci, Marvin Pollum, Carlos Crespo-Hernández, Maurizio Persico, Ines Corral Perez
Photosensitization of DNA by thionucleosides is a promising photo-chemotherapeutic treatment option for a variety of malignancies. DNA metabolization of thiated prodrugs can lead to cell death upon exposure to a low dose of UVA light. The exact mechanisms of thionucleoside phototoxicity are still not fully understood. In this work, we have combined femtosecond broadband transient absorption experiments with state-of-the-art molecular simulations to provide mechanistic insights for the ultrafast and efficient population of the triplet-state in the UVA-activated pyrimidine anticancer drug: 4-thiothymine...
December 2, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27904274/pretreatment-of-ferulic-acid-protects-human-dermal-fibroblasts-against-ultraviolet-a-irradiation
#7
Hyung Jin Hahn, Ki Bbeum Kim, Seunghee Bae, Byung Gon Choi, Sungkwan An, Kyu Joong Ahn, Su Young Kim
BACKGROUND: Approximately 90%~99% of ultraviolet A (UVA) ray reaches the Earth's surface. The deeply penetrating UVA rays induce the formation of reactive oxygen species (ROS), which results in oxidative stress such as photoproducts, senescence, and cell death. Thus, UVA is considered a primary factor that promotes skin aging. OBJECTIVE: Researchers investigated whether pretreatment with ferulic acid protects human dermal fibroblasts (HDFs) against UVA-induced cell damages...
December 2016: Annals of Dermatology
https://www.readbyqxmd.com/read/27902870/a-thioacetal-photocage-designed-for-dual-release-application-in-the-quantitation-of-therapeutic-release-by-synchronous-reporter-decaging
#8
Pamela T Wong, Shengzhuang Tang, Jayme Cannon, Jhindan Mukherjee, Danielle Isham, Kristina Gam, Michael Payne, Sean A Yanik, James R Baker, Seok Ki Choi
Despite the immense potential of existing photocaging technology, its application is limited by the paucity of advanced caging tools. Here, we report on the design of a novel thioacetal ortho-nitrobenzaldehyde (TNB) dual arm photocage that enabled control of the simultaneous release of two payloads linked to a single TNB unit. By using this cage, which was prepared in a single step from commercial 6-nitroverataldehyde, three drug-fluorophore conjugates were synthesized: Taxol-TNB-fluorescein, Taxol-TNB-coumarin, and doxorubicin-TNB-coumarin, and long-wavelength UVA light-triggered release experiments demonstrated that dual payload release occurred with rapid decay kinetics for each conjugate...
November 7, 2016: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/27901001/ultraviolet-a-enhances-cathepsin-l-expression-and-activity-via-jnk-pathway-in-human-dermal-fibroblasts
#9
Qing-Fang Xu, Yue Zheng, Jian Chen, Xin-Ya Xu, Zi-Jian Gong, Yun-Fen Huang, Chun Lu, Howard I Maibach, Wei Lai
BACKGROUND: Cathepsin L (CatL) is a cysteine protease with strong matrix degradation activity that contributes to photoaging. Mannose phosphate-independent sorting pathways mediate ultraviolet A (UVA)-induced alternate trafficking of CatL. Little is known about signaling pathways involved in the regulation of UVA-induced CatL expression and activity. This study aims to investigate whether a single UVA irradiation affects CatL expression and activity and whether mitogen-activated protein kinase (MAPK)/activator protein-1 (AP-1) pathway is involved in the regulation of UVA-induced CatL expression and activity in human dermal fibroblasts (HDFs)...
2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27892893/photoprotective-and-radioprotective-properties-of-nitroxides-and-their-application-in-magnetic-resonance-imaging
#10
Marcin Lewandowski, Krzysztof Gwoździński
Nitroxides are a group of stable organic radicals of low molecular weight having a nitroxyl group > N-.O, which has an unpaired electron. The presence of this group allows a nitroxide to participate in redox reactions. They serve as mimics of superoxide dismutase (SOD) and have stimulative properties towards haemoproteins with catalase-like activity. Nitroxides oxidize Fe (II) to Fe (III) preventing the Fenton and Haber-Weiss reactions. As the radicals have the ability to scavenge other free radicals. Nitroxides are not immunogenic, and mutagenic and do not show toxicity to the human cells...
October 14, 2016: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/27890427/internal-and-external-generalizability-of-temporal-dose-response-relationships-for-xerostomia-following-imrt-for-head-and-neck-cancer
#11
Maria Thor, Adepitan A Owosho, Haley D Clark, Jung Hun Oh, Nadeem Riaz, Allan Hovan, Jillian Tsai, Steven D Thomas, Sae Hee K Yom, Jonn S Wu, Joseph M Huryn, Vitali Moiseenko, Nancy Y Lee, Cherry L Estilo, Joseph O Deasy
BACKGROUND AND PURPOSE: To study internal and external generalizability of temporal dose-response relationships for xerostomia after intensity-modulated radiotherapy (IMRT) for head and neck cancer, and to investigate potential amendments of the QUANTEC guidelines. MATERIAL AND METHODS: Objective xerostomia was assessed in 121 patients (nCohort1=55; nCohort2=66) treated to 70Gy@2Gy in 2006-2015. Univariate and multivariate analyses (UVA, MVA with 1000 bootstrap populations) were conducted in Cohort1, and generalizability of the best-performing MVA model was investigated in Cohort2 (performance: AUC, p-values, and Hosmer-Lemeshow p-values (pHL))...
November 24, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27871123/a-focus-on-quality-and-safety-traits-of-saccharomyces-cerevisiae-isolated-from-uva-di-troia-grape-variety
#12
Leonardo Petruzzi, Antonio Bevilacqua, Maria Rosaria Corbo, Barbara Speranza, Vittorio Capozzi, Milena Sinigaglia
The aim of this work was to study Saccharomyces cerevisiae strains isolated from vineyards of the autochthonous grape variety "Uva di Troia" located in different geographical areas of Apulian region (Southern Italy). Four hundred isolates were studied in relation to H2 S production, β-glucosidase activity, and pigments adsorption from grape skin. Thus, 81 isolates were selected, identified through the amplification of the interdelta region, and grouped in 19 biotypes (from I to XIX). The enological performances were assessed to determine the content of residual sugars, ethanol, glycerol, and volatile acidity, after a microfermentation in Uva di Troia must for each isolate...
November 21, 2016: Journal of Food Science
https://www.readbyqxmd.com/read/27864112/polar-extracts-from-the-berry-like-fruits-of-hypericum-androsaemum-l-as-a-promising-ingredient-in-skin-care-formulations
#13
Fabiana Antognoni, Mariacaterina Lianza, Ferruccio Poli, Michela Buccioni, Claudia Santinelli, Giovanni Caprioli, Romilde Iannarelli, Giulio Lupidi, Elisabetta Damiani, Daniela Beghelli, Alessia Alunno, Filippo Maggi
ETHNOPHARMACOLOGICAL RELEVANCE: The top flowering aerial parts of the Hypericum species are traditionally used to prepare ointments to heal cuts and burns. Sometimes even the fruits are used for these purposes. Hypericum androsaemum L., commonly known as tutsan or shrubby St. John's Wort, is a Mediterranean medicinal plant which has been traditionally used to prepare an ointment for treating cuts and wounds. AIM OF THE STUDY: To evaluate the extracts obtained from H...
November 15, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27864061/melanogenesis-inhibits-respiration-in-b16-f10-melanoma-cells-whereas-enhances-mitochondrial-cell-content
#14
Willian Vanderlei Meira, Tassiele Andréa Heinrich, Silvia Maria Suter Correia Cadena, Glaucia Regina Martinez
Melanoma is a rare and aggressive skin tumor; the survival of patients diagnosed late is fairly low. This high mortality rate is due to the characteristics of the cells that allow them to be resistant to radiotherapy and conventional chemotherapy, besides of being able to evade the immune system. Melanin, the pigment responsible for skin, hair and eye color, seems to be involved in this resistance. The main function of melanin is to protect the cells against ultraviolet (UV) light by absorbing this radiation and reactive oxygen species (ROS) scavenging...
November 15, 2016: Experimental Cell Research
https://www.readbyqxmd.com/read/27863243/the-c-%C3%A2-elegans-taste-receptor-homolog-lite-1-is-a-photoreceptor
#15
Jianke Gong, Yiyuan Yuan, Alex Ward, Lijun Kang, Bi Zhang, Zhiping Wu, Junmin Peng, Zhaoyang Feng, Jianfeng Liu, X Z Shawn Xu
Many animal tissues/cells are photosensitive, yet only two types of photoreceptors (i.e., opsins and cryptochromes) have been discovered in metazoans. The question arises as to whether unknown types of photoreceptors exist in the animal kingdom. LITE-1, a seven-transmembrane gustatory receptor (GR) homolog, mediates UV-light-induced avoidance behavior in C. elegans. However, it is not known whether LITE-1 functions as a chemoreceptor or photoreceptor. Here, we show that LITE-1 directly absorbs both UVA and UVB light with an extinction coefficient 10-100 times that of opsins and cryptochromes, indicating that LITE-1 is highly efficient in capturing photons...
November 17, 2016: Cell
https://www.readbyqxmd.com/read/27861561/the-expression-of-the-endogenous-mtorc1-inhibitor-sestrin-2-is-induced-by-uvb-and-balanced-with-the-expression-level-of-sestrin-1
#16
Veronika Mlitz, Gaelle Gendronneau, Irina Berlin, Maria Buchberger, Leopold Eckhart, Erwin Tschachler
Sestrin 2 (SESN2) is an evolutionarily conserved regulator of mechanistic target of rapamycin complex 1 (mTORC1) which controls central cellular processes such as protein translation and autophagy. Previous studies have suggested that SESN2 itself is subjected to regulation at multiple levels. Here, we investigated the expression of SESN2 in the skin and in isolated skin cells. SESN2 was detected by immunofluorescence analysis in fibroblasts and keratinocytes of human skin. Differentiation of epidermal keratinocytes was not associated with altered SESN2 expression and siRNA-mediated knockdown of SESN2 did not impair stratum corneum formation in vitro...
2016: PloS One
https://www.readbyqxmd.com/read/27860496/predicting-insulin-treatment-scenarios-with-the-net-effect-method-domain-of-validity
#17
Martina Vettoretti, Andrea Facchinetti, Giovanni Sparacino, Claudio Cobelli
BACKGROUND: A simulation methodology based on the net effect, a signal estimated from continuous glucose monitoring (CGM) and insulin data accounting for sources of glucose variability, for example, meals and exercise, has been proposed. This method has been recently used to "replay" real-life treatment scenarios and determine the minimal level of CGM sensor accuracy required for nonadjunctive use. Given the potential of the net effect method, it is important to assess its domain of validity...
November 2016: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/27858793/photocatalytic-degradation-of-rhodamine-b-paracetamol-and-diclofenac-sodium-by-supported-titania-based-catalysts-from-petrochemical-residue-effect-of-doping-with-magnesium
#18
William Leonardo da Silva, Marla Azário Lansarin, João Henrique Z Dos Santos, Fernando Silveira
Three different lots of a residual Ziegler-Natta catalyst slurry (bearing Ti and Mg) obtained from an industrial petrochemical plant were employed as sources for the photocatalyst supported on silica. The effect of additional magnesium (1.0-25.0 wt% Mg/SiO2) on the photocatalytic properties of the doped materials was investigated. Doping the titania-based photocatalyst with Mg results in a shift in the absorption threshold toward the visible spectrum. The optical band gap energy of the bare supported photocatalyst was in the range of 2...
November 2016: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/27857331/highly-sensitive-uva-and-violet-photodetector-based-on-single-layer-graphene-tio-sub-2-sub-heterojunction
#19
Feng-Xia Liang, Deng-Yue Zhang, Jiu-Zhen Wang, Wei-Yu Kong, Zhi-Xiang Zhang, Yi Wang, Lin-Bao Luo
A highly sensitive ultraviolet A (UVA) and violet photodetector based on p-type single-layer graphene (SLG)-TiO<sub>2</sub> heterostructure was fabricated by transferring chemical vapor deposition derived SLG on the surface of commercial single-crystal TiO<sub>2</sub> wafer. Optoelectronic analysis reveals the as-fabricated Schottky junction PD was highly sensitive to light illumination in UVA and violet range, with peak sensitivity at 410 nm and excellent stability and reproducibility, but virtually blind to illumination with wavelength less than 350 nm or more than 460 nm...
November 14, 2016: Optics Express
https://www.readbyqxmd.com/read/27854351/a-mixture-of-extracts-of-kochia-scoparia-and-rosa-multiflora-with-ppar-%C3%AE-%C3%AE-dual-agonistic-effects-prevents-photoaging-in-hairless-mice
#20
Hyerin Jeon, Dong Hye Kim, Youn-Hwa Nho, Ji-Eun Park, Su-Nam Kim, Eung Ho Choi
Activation of peroxisome proliferator-activated receptors (PPAR) α/γ is known to inhibit the increases in matrix metalloproteinase (MMP) and reactive oxygen species (ROS) induced by ultraviolet light (UV). Extracts of natural herbs, such as Kochia scoparia and Rosa multiflora, have a PPAR α/γ dual agonistic effect. Therefore, we investigated whether and how they have an antiaging effect on photoaging skin. Eighteen-week-old hairless mice were irradiated with UVA 14 J/cm² and UVB 40 mJ/cm² three times a week for 8 weeks...
November 16, 2016: International Journal of Molecular Sciences
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