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https://www.readbyqxmd.com/read/29031212/a-comprehensive-analysis-of-direct-and-photosensitized-attenuation-of-toxoplasma-gondii-tachyzoites
#1
Juan G Yañuk, M Lis Alomar, M Micaela Gonzalez, Andrés M Alonso, Sergio O Angel, Verónica M Coceres, Franco M Cabrerizo
In the present work, we have evaluated the effect of three different types of radiation: UVC (254±5nm), UVA (365±20nm) and visible (420±20nm) on different morphological and biological functions of Toxoplasma gondii tachyzoites. Briefly, UVC and UVA showed an inhibitory effect on parasite invasion in a dose-dependent manner. UVC showed the strongest effect inducing both structural damage (antigens) and functional inhibition (i.e., invasion and replication). On its own, visible light induces a quite distinctive and selective pattern of parasite-attenuation...
October 7, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29031210/effect-of-photoactivated-riboflavin-on-the-biodegradation-resistance-of-root-dentin-collagen
#2
Balasankar Meera Priyadarshini, Thong Beng Lu, Amr S Fawzy
This study was conducted to evaluate the effect of UVA-activated 1% riboflavin solution on structural integrity; mechanical properties and stability; and collagenase-mediated collagen solubilisation resistance of demineralized root dentin collagen matrix. Root dentin specimens demineralized with 17% EDTA for 7days were treated with 1% RF for 1min followed by UVA photo-activation at intensity 7mW/cm(2) for 1min. Control specimens were completely devoid of riboflavin and/or UVA treatments. Specimens were challenged with bacterial collagenase type-I solution for different time-periods at 37°C...
October 8, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29029110/2017-eacts-guidelines-on-perioperative-medication-in-adult-cardiac-surgery
#3
Miguel Sousa-Uva, Stuart J Head, Milan Milojevic, Jean-Philippe Collet, Giovanni Landoni, Manuel Castella, Joel Dunning, Tómas Gudbjartsson, Nick J Linker, Elena Sandoval, Matthias Thielmann, Anders Jeppsson, Ulf Landmesser
No abstract text is available yet for this article.
October 6, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29029100/2017-eacts-eacta-guidelines-on-patient-blood-management-for-adult-cardiac-surgery-the-task-force-on-patient-blood-management-for-adult-cardiac-surgery-of-the-european-association-for-cardio-thoracic-surgery-eacts-and-the-european-association-of-cardiothoracic
#4
Domenico Pagano, Milan Milojevic, Michael I Meesters, Umberto Benedetto, Daniel Bolliger, Christian von Heymann, Anders Jeppsson, Andreas Koster, Ruben L Osnabrugge, Marco Ranucci, Hanne Berg Ravn, Alexander B A Vonk, Alexander Wahba, Christa Boer, Moritz W V Wyler von Ballmoos, Mate Petricevic, Arie Pieter Kappetein, Miguel Sousa-Uva, Georg Trummer, Peter M Rosseel, Michael Sander, Pascal Colson, Adrian Bauer
No abstract text is available yet for this article.
October 3, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29020475/association-khellin-and-308-nm-excimer-lamp-in-the-treatment-of-severe-alopecia-areata-in-a-child
#5
Samy Fenniche, Houda Hammami, Anissa Zaouak
Alopecia areata (AA) is an autoimmune inflammatory disorder of hair, characterized by non-scarring hair loss. 308-nm Excimer lamp (EL) has been reported as one effective modality in the treatment of AA. Khellin is a furanochromone photosensitizer whose chemical structure is close to psoralens and has previously proven its efficacy in vitiligo in association with UVA. We evaluated the efficacy and safety of a combination of topical khellin and 308-nm EL in the treatment of a refractory ophiasic AA (OAA), of 1-year evolution, in a 5-year-old boy...
October 11, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28991335/customized-corneal-cross-linking-using-different-uva-beam-profiles
#6
Rohit Shetty, Natasha Pahuja, Thimmarayappa Roshan, Rashmi Deshmukh, Mathew Francis, Arkasubhra Ghosh, Abhijit Sinha Roy
PURPOSE: To evaluate the performance of different customized corneal cross-linking (CXL) methods. METHODS: This was a single-center interventional, prospective, longitudinal case series. Four different customized CXL methods were evaluated in keratoconic eyes: (1) uniform (uniform intensity ultraviolet-A [UVA] beam [9 mW/cm(2)] for 10 minutes) (n = 12 eyes); (2) sector axial map (sector-based UVA irradiation) (n = 12 eyes); (3) ring axial map (concentric rings of UVA beam intensity centered at the steepest curvature of the anterior axial map) (n = 12 eyes); and ring tangential map (same as the ring axial map but centered at the steepest curvature of the anterior tangential map) (n = 14 eyes)...
October 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28986771/degradation-of-propyl-paraben-by-activated-persulfate-using-iron-containing-magnetic-carbon-xerogels-investigation-of-water-matrix-and-process-synergy-effects
#7
Maria Evangelia Metheniti, Zacharias Frontistis, Rui S Ribeiro, Adrián M T Silva, Joaquim L Faria, Helder T Gomes, Dionissios Mantzavinos
An advanced oxidation process comprising an iron-containing magnetic carbon xerogel (CX/Fe) and persulfate was tested for the degradation of propyl paraben (PP), a contaminant of emerging concern, in various water matrices. Moreover, the effect of 20 kHz ultrasound or light irradiation on process performance was evaluated. The pseudo-first order degradation rate of PP was found to increase with increasing SPS concentration (25-500 mg/L) and decreasing PP concentration (1690-420 μg/L) and solution pH (9-3)...
October 6, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28982862/photodynamic-therapy-using-indolines-fused-triazoles-induces-mitochondrial-apoptosis-in-human-non-melanoma-bcc-cells
#8
Wan-Ping Hu, Kung-Kai Kuo, Gopal Chandru Senadi, Long-Sen Chang, Jeh-Jeng Wang
BACKGROUND/AIM: Cancer is one of the most dreadful diseases in humans and among them non-melanoma skin cancer (NMSC) is an increasing problem in the world, that occurs more frequently in people with fair skin. Photodynamic therapy (PDT), a non-invasive treatment is widely used for the prevention and treatment of BCC cells. We previously reported an efficient synthesis of novel indolines-fused-triazoles and studied their photophysical studies. This study delineated the signaling pathways involved in the PDT effect of triazoles on BCC cells under UVA irradiation...
October 2017: Anticancer Research
https://www.readbyqxmd.com/read/28975707/skin-penetration-and-uv-damage-prevention-by-nanoberries
#9
Paula Bucci, María Jimena Prieto, Laura Milla, María Natalia Calienni, Luis Martinez, Viviana Rivarola, Silvia Alonso, Jorge Montanari
BACKGROUND: Ethanolic extract from blueberry (Vaccinium myrtillus) is rich in anthocyanins and thus exhibits antioxidant activity. On the other hand, ultradeformable liposomes are capable of penetrating to the impermeable barrier of skin. Nanoberries are ultradeformable liposomes carrying blueberry extract. OBJECTIVES: In this study, their capacity to penetrate the stratum corneum and photodamage prevention were tested, with the aim of developing a topical formulation for skin protection from environmental damage...
October 3, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28975170/thiol-ene-epoxy-thermoset-for-low-temperature-bonding-to-biofunctionalized-microarray-surfaces
#10
Xiamo C Zhou, Ronald Sjöberg, Amaury Druet, Jochen M Schwenk, Wouter van der Wijngaart, Tommy Haraldsson, Carl Fredrik Carlborg
One way to improve the sensitivity and throughput of miniaturized biomolecular assays is to integrate microfluidics to enhance the transport efficiency of biomolecules to the reaction sites. Such microfluidic integration requires bonding of a prefabricated microfluidic gasket to an assay surface without destroying its biological activity. In this paper we address the largely unmet challenge to accomplish a proper seal between a microfluidic gasket and a protein surface, with maintained biological activity and without contaminating the surface or blocking the microfluidic channels...
October 4, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28974429/the-validation-of-a-novel-robot-assisted-radical-prostatectomy-virtual-reality-module
#11
Patrick Harrison, Nicholas Raison, Takashige Abe, William Watkinson, Faizan Dar, Ben Challacombe, Henk Van Der Poel, Muhammad Shamim Khan, Prokar Dasgupa, Kamran Ahmed
OBJECTIVE: To perform the first validation of a full procedural virtual reality robotic training module and analysis of novice surgeon's learning curves. DESIGN: Participants completed the bladder neck dissection task and urethrovesical anastomosis task (UVA) as part of the prostatectomy module. Surgeons completed feedback questionnaires assessing the realism, content, acceptability and feasibility of the module. Novice surgeons completed a 5.5-hour training programme using both tasks...
September 30, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28970517/human-in-vitro-model-reveals-the-effects-of-collagen-cross-linking-on-keratoconus-pathogenesis
#12
Rabab Sharif, Jesper Hjortdal, Henrik Sejersen, Garett Frank, Dimitrios Karamichos
Keratoconus (KC) is a corneal thinning disorder that leads to severe vision impairment As opposed to corneal transplantation; corneal collagen crosslinking (CXL) is a relatively non-invasive procedure that leads to an increase in corneal stiffness. In order to evaluate the effect of CXL on human corneal stromal cells in vitro, we developed a 3-D in vitro CXL model, using primary Human corneal fibroblasts (HCFs) from healthy patients and Human Keratoconus fibroblasts (HKCs) from KC patients. Cells were plated on transwell polycarbonate membranes and stimulated by a stable vitamin C...
October 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28967660/ultrathin-znse-nanowires-one-pot-synthesis-via-a-heat-triggered-precursor-slow-releasing-route-controllable-mn-doping-and-application-in-uv-and-near-visible-light-detection
#13
Dong Li, Guanjie Xing, Shilin Tang, Xiaohong Li, Louzhen Fan, Yunchao Li
We report herein a heat-triggered precursor slow releasing route for the one-pot synthesis of ultrathin ZnSe nanowires (NWs), which relies on the gradual dissolving of Se powder into oleylamine containing a soluble Zn precursor under heating. This route allows the reaction system to maintain a high monomer concentration throughout the entire reaction process, thus enabling the generation of ZnSe NWs with diameter down to 2.1 nm and length approaching 400 nm. The size-dependent optical properties and band-edge energy levels of the ZnSe NWs were then explored in depth by UV-visible spectroscopy and cyclic voltammetry, respectively...
October 12, 2017: Nanoscale
https://www.readbyqxmd.com/read/28967077/morphology-of-the-optic-nerve-head-in-glaucomatous-eyes-with-visual-field-defects-in-superior-or-inferior-hemifield
#14
Antonio Longo, Teresio Avitabile, Maurizio G Uva, Vincenza Bonfiglio, Andrea Russo, Mario D Toro, Salvatore Faro, Michele Reibaldi
PURPOSE: To evaluate the morphology of optic nerve head (ONH) and border tissue (BT) of Elschnig in glaucomatous eyes with visual field defects in superior or inferior hemifield. METHODS: In a case-control study, we included 25 patients with superior arcuate scotoma, 25 patients with inferior arcuate scotoma, and 25 healthy controls. They received visual field testing, measurement of peripapillary retinal nerve fiber layer (RNFL) thickness, and ONH examination in a radial pattern with spectral-domain optical coherence tomography...
September 25, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28963702/in-vivo-confocal-laser-microscopy-of-morphologic-changes-after-small-incision-lenticule-extraction-with-accelerated-cross-linking-smile-xtra-in-patients-with-thin-corneas-and-high-myopia
#15
Yugui Zhou, Manli Liu, Ting Zhang, Hua Zheng, Yuan Sun, Xiaonan Yang, Shengbei Weng, Haiqin Lin, Quan Liu
PURPOSE: To evaluate the microstructural modifications and safety of small incision lenticule extraction combined with accelerated cross-linking (SMILE Xtra) in high myopia and thin corneas by means of in vivo confocal microscopy (IVCM) and 3D-OCT after a 6-month follow-up. METHODS: Forty-three eyes with high myopia and thin corneas were enrolled. All eyes underwent SMILE procedure. After the lenticule was extracted, 0.25% riboflavin was injected into the interface and allowed to diffuse for 60 s...
September 29, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28962194/polycomb-group-proteins-novel-molecules-associated-with-ultraviolet-a-induced-photoaging-of-human-skin
#16
Zhuoxia Wu, Lianbo Zhang
Epigenetic repressor polycomb group (PcG) proteins are thought to serve a role in a number of cellular processes, including carcinogenesis, senescence, apoptosis and DNA repair. In the present study, long-wave ultraviolet A (UVA) was used to irradiate human skin fibroblasts (HSFs) and embryonic skin fibroblasts (ESFs) in order to simulate photoaging of the skin. The results of cell proliferation, apoptosis, hyaluronic acid (HA) content and reverse transcription-quantitative polymerase chain reaction assays revealed that the expression levels of genes encoding key PcG proteins (BMI-1 and EZH2) were altered...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28960450/pterygium-inversum-unguis-secondary-to%C3%A2-gel-polish
#17
J Cervantes, M Sanchez, A E Eber, M Perper, A Tosti
BACKGROUND: Pterygium inversum unguis (PIU) is characterized by the abnormal adherence of the hyponychium to the ventral surface of the nail plate. It can be both unsightly and painful, resulting in morbidity for patients. Gel polish is a popular nail cosmetic that has been reported to cause several complications. PIU may be another adverse outcome. OBJECTIVE: To highlight a newly-recognized adverse effect of a popular beauty technique. METHODS: This retrospective and prospective case series reports 17 women who developed PIU after gel polish use...
September 28, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28957960/the-glaucoma-italian-pediatric-study-gipsy-1-year-results
#18
Luciano Quaranta, Elena Biagioli, Ivano Riva, Francesca Galli, Davide Poli, Eliana Rulli, Andreas Katsanos, Antonio Longo, Maurizio G Uva, Valter Torri, Robert N Weinreb
PURPOSE: To investigate the efficacy and safety of a treatment strategy with latanoprost and dorzolamide in primary pediatric glaucoma patients partially responsive to surgery. PATIENTS AND METHODS: Children with primary pediatric glaucoma having postsurgical untreated intraocular pressure (IOP) between 22 and 26 mm Hg were eligible. At baseline, patients were administered latanoprost once daily. Depending on IOP reduction, patients were allocated to continuation of latanoprost monotherapy or addition of dorzolamide twice daily, or switch to dorzolamide monotherapy 3 times daily...
September 27, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28952614/quercetin-and-its-analogues-optical-and-acido-basic-properties
#19
Michal Biler, David Biedermann, Kateřina Valentová, Vladimír Křen, Martin Kubala
This study is focused on eight structurally analogous natural flavonoids that exhibit a wide range of biological activities, which are of interest in pharmacy, cosmetics and the food industry. Using both experimental and theoretical approaches, we relate their fundamental physico-chemical properties to the structural motifs, with particular focus on UV/Vis absorption properties and pH dependence. We highlight the role of the C2-C3 double bond, whose presence or absence is responsible for the switch between absorption bands in the UVB and UVA regions, which is rationalized by strong modification of the involved molecular orbitals...
October 11, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28952380/in-silico-modeling-of-minimal-effective-insulin-doses-using-the-uva-padova-type-1-diabetes-simulator
#20
Enrique Campos-Náñez, Jennifer E Layne, Howard C Zisser
BACKGROUND: The objective of this study was to identify the minimum basal insulin infusion rates and bolus insulin doses that would result in clinically relevant changes in blood glucose levels in the most insulin sensitive subjects with type 1 diabetes. METHODS: The UVA/PADOVA Type 1 Diabetes Simulator in silico population of children, adolescents, and adults was administered a basal insulin infusion rate to maintain blood glucose concentrations at 120 mg/dL (6...
September 1, 2017: Journal of Diabetes Science and Technology
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