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https://www.readbyqxmd.com/read/29457632/rapid-eradication-of-bacterial-phytopathogens-by-atmospheric-pressure-glow-discharge-generated-in-contact-with-a-flowing-liquid-cathode
#1
Agata Motyka, Anna Dzimitrowicz, Piotr Jamroz, Ewa Lojkowska, Wojciech Sledz, Pawel Pohl
Diseases caused by phytopathogenic bacteria are responsible for significant economic losses, and these bacteria spread through diverse pathways including waterways and industrial wastes. It is therefore of interest to develop potent methods for their eradication. Here, antibacterial properties of direct current atmospheric pressure glow discharge (dc-APGD) generated in contact with flowing bacterial suspensions were examined against five species of phytopathogens. Complete eradication of Clavibacter michiganensis subsp...
February 19, 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29456585/neuroinflammation-and-neurohormesis-in-the-pathogenesis-of-alzheimer-s-disease-and-alzheimer-linked-pathologies-modulation-by-nutritional-mushrooms
#2
REVIEW
Angela Trovato Salinaro, Manuela Pennisi, Rosanna Di Paola, Maria Scuto, Rosalia Crupi, Maria Teresa Cambria, Maria Laura Ontario, Mario Tomasello, Maurizio Uva, Luigi Maiolino, Edward J Calabrese, Salvatore Cuzzocrea, Vittorio Calabrese
Human life develops and expands not only in time and space, but also in the retrograde permanent recollection and interweaving of memories. Therefore, individual human identity depends fully on a proper access to the autobiographical memory. Such access is hindered or lost under pathological conditions such as Alzheimer's disease, including recently associated oxidant pathologies, such as ocular neural degeneration occurring in glaucoma or neurosensorial degeneration occurring in Menière's disease. Oxidative stress and altered antioxidant systems have been suggested to play a role in the aetiology of major neurodegenerative disorders, and altered expression of genes sensing oxidative stress, as well as decreased cellular stress response mechanisms could synergistically contribute to the course of these oxidant disorders...
2018: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/29456555/a-bootstrap-based-measure-robust-to-the-choice-of-normalization-methods-for-detecting-rhythmic-features-in-high-dimensional-data
#3
Yolanda Larriba, Cristina Rueda, Miguel A Fernández, Shyamal D Peddada
Motivation: Gene-expression data obtained from high throughput technologies are subject to various sources of noise and accordingly the raw data are pre-processed before formally analyzed. Normalization of the data is a key pre-processing step, since it removes systematic variations across arrays. There are numerous normalization methods available in the literature. Based on our experience, in the context of oscillatory systems, such as cell-cycle, circadian clock, etc., the choice of the normalization method may substantially impact the determination of a gene to be rhythmic...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/29455976/near-infrared-emissive-lanthanide-hybridized-nanofibrillated-cellulose-nanopaper-as-ultraviolet-filter
#4
Bailiang Xue, Zhao Zhang, Yongchang Sun, Junjie Wang, Huie Jiang, Min Du, Congcong Chi, Xinping Li
The lanthanide complexes [Yb(fac)3 (H2 O)2 , Yb(tta)3 (H2 O)2 , Nd(tta)3 (H2 O)2 ] functionalized nanofibrillated cellulose (Ln-NFC) nanopapers with near-infrared (NIR) luminescence and high transparency are rapidly fabricated after solvent exchange using a simple suction filtration film-making method. The effects of NFC and lanthanide complexes content on their photophysical properties of Ln-NFC nanopapers and their mechanism of UV filters are fully investigated. With increasing lanthanide complexes content in the Ln-NFC nanopaper, their transmittances are gradually decreased while their NIR luminescences are obviously increased...
April 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29455850/proteins-involved-in-the-antioxidant-and-inflammatory-response-in-rutin-treated-human-skin-fibroblasts-exposed-to-uva-or-uvb-irradiation
#5
Agnieszka Gęgotek, Pedro Domingues, Elżbieta Skrzydlewska
BACKGROUND: Rutin, due to its polyphenolic structure, has antioxidant properties and can be used as a cytoprotective compound against UV-induced effects on skin cells. OBJECTIVE: The aim of this study was to examine the effect of rutin on proteomic profile in human skin fibroblasts irradiated with UV dose that induces apoptosis. METHODS: Proteome analysis based on the results obtained by the QExactive OrbiTrap mass spectrometer. RESULTS: Results show that rutin treatment more strongly protects against UVA-induced rather than UVB-induced increases in the total expression of proteins involved in antioxidant (such as SOD, TrxR, and Prxs 1/2) and inflammatory response (e...
February 15, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29453117/performance-of-integrated-ferrate-polyaluminum-chloride-coagulation-as-a-treatment-technology-for-removing-freshwater-humic-substances
#6
Mitsuru Amano, Jenyuk Lohwacharin, Alice Dubechot, Satoshi Takizawa
Ferrate-based technologies can play versatile roles in water treatment because of their potential for in situ production and because they do not form any harmful by-products. We compared the oxidative performance of Fe(VI) generated by an electrochemical process, with H 2 O 2 -UV irradiation (a standard oxidation process) for removing Suwannee River natural organic matter. It took only 5 min for Fe(VI) (Fe: 1.67 × 10 -4 M) to reduce the fluorescence intensity of a humic-like fluorophore by 36% of the original value; in contrast, it took 120 min of irradiation using H 2 O 2 -UV ([OH] ∼ 1...
February 13, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29451308/apheresis-buffy-coat-collection-without-photoactivation-has-no-effect-on-apoptosis-cell-proliferation-and-total-viability-of-mononuclear-cells-collected-using-photopheresis-systems
#7
Zbigniew M Szczepiorkowski, Christine A Burnett, Larry J Dumont, Sunil H Abhyankar
BACKGROUND: Extracorporeal photopheresis (ECP) has been approved for the treatment of advanced cutaneous T-cell lymphoma since 1988. While the precise mechanisms resulting in clinical effects are not fully understood, the photoactivation of mononuclear cells (MNCs) using ultraviolet A (UVA) light and methoxsalen is believed to be the predominant initiating process. The effects of MNC passage through the instrument without photoactivation are unknown. The objective of this study was to evaluate the effect of cell processing through the photopheresis instruments on MNCs...
February 16, 2018: Transfusion
https://www.readbyqxmd.com/read/29451021/the-uva-padova-type-1-diabetes-simulator-goes-from-single-meal-to-single-day
#8
Roberto Visentin, Enrique Campos-Náñez, Michele Schiavon, Dayu Lv, Martina Vettoretti, Marc Breton, Boris P Kovatchev, Chiara Dalla Man, Claudio Cobelli
BACKGROUND: A new version of the UVA/Padova Type 1 Diabetes (T1D) Simulator is presented which provides a more realistic testing scenario. The upgrades to the previous simulator, which was accepted by the Food and Drug Administration in 2013, are described. METHOD: Intraday variability of insulin sensitivity (S I ) has been modeled, based on clinical T1D data, accounting for both intra- and intersubject variability of daily S I . Thus, time-varying distributions of both subject's basal insulin infusion and insulin-to-carbohydrate ratio were calculated and made available to the user...
February 1, 2018: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/29450621/ngf-protects-corneal-retinal-and-cutaneous-tissues-cells-from-phototoxic-effect-of-uv-exposure
#9
Maria Luisa Rocco, Bijorn Omar Balzamino, Luigi Aloe, Alessandra Micera
PURPOSE: Based on evidence that nerve growth factor (NGF) exerts healing action on damaged corneal, retinal, and cutaneous tissues, the present study sought to assess whether topical NGF application can prevent and/or protect epithelial cells from deleterious effects of ultraviolet (UV) radiation. METHODS: Eyes from 40 young-adult Sprague Dawley rats and cutaneous tissues from 36 adult nude mice were exposed to UVA/B lamp for 60 min, either alone or in the presence of murine NGF...
February 15, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29447842/neutrophils-drive-type-i-interferon-production-and-autoantibodies-in-wiskott-aldrich-syndrome
#10
K E Cervantes-Luevano, N Caronni, M C Castiello, E Fontana, G Piperno, A Naseem, P Uva, M Bosticardo, G E Marcovecchio, L D Notarangelo, M P Cicalese, A Aiuti, A Villa, F Benvenuti
BACKGROUND: Wiskott-Aldrich syndrome (WAS) is a rare primary immunodeficiency caused by mutations in WASp, a key regulator of cytoskeletal dynamics in hematopoietic cells. A high proportion of patients develop autoimmunity due to a breakdown in T and B cell tolerance. Moreover, excessive production of type-I interferon by plasmacytoid DCs contribute to autoimmune signs, however, the factors that triggers excessive innate activation have not been defined. OBJECTIVE: Neutrophils extracellular traps (NETs) emerged as major initiating factors in diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA)...
February 12, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29441025/the-effect-of-lower-body-positive-pressure-on-the-cardiorespiratory-response-at-rest-and-during-submaximal-running-exercise
#11
Frédéric Stucky, Jean-Marc Vesin, Bengt Kayser, Barbara Uva
Anti-gravity treadmills facilitate locomotion by lower-body positive pressure (LBPP). Effects on cardiorespiratory regulation are unknown. Healthy men (30 ± 8 y, 178.3 ± 5.7 cm, 70.3 ± 8.0 kg; mean ± SD) stood upright ( n = 10) or ran ( n = 9) at 9, 11, 13, and 15 km.h-1(5 min stages) with LBPP (0, 15, 40 mmHg). Cardiac output (CO), stroke volume (SV), heart rate (HR), blood pressure (BP), peripheral resistance (PR), and oxygen uptake (VO2) were monitored continuously. During standing, LBPP increased SV [by +29 ± 13 (+41%) and +42 ± 15 (+60%) ml, at 15 and 40 mmHg, respectively ( p < 0...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29429006/exercise-capacity-and-cancer-specific-quality-of-life-following-curative-intent-treatment-of-stage-i-iiia-lung-cancer
#12
Duc Ha, Andrew L Ries, Peter J Mazzone, Scott M Lippman, Mark M Fuster
PURPOSE: Lung cancer survivors are at risk for health impairments resulting from the effects and/or treatment of lung cancer and comorbidities. Practical exercise capacity (EC) assessments can help identify impairments that would otherwise remain undetected. In this study, we characterized and analyzed the association between functional EC and cancer-specific quality of life (QoL) in lung cancer survivors who previously completed curative intent treatment. METHODS: In a cross-sectional study of 62 lung cancer survivors who completed treatment ≥ 1 month previously, we assessed functional EC with the 6-min walk distance (6MWD) and cancer-specific QoL with the European Organization for Research and Treatment of Cancer QoL Questionnaire Core 30 (EORTC-QLQ-C30)...
February 10, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29424726/inhibition-of-daphnia-magna-s-occurrence-in-drinking-water-treatment-process-by-controlling-its-phototactic-behavior
#13
Tao Lin, Yiwen Tan, Wei Chen
Cladocera zooplankton as carriers of bacteria result in biological risk due to their occurrence in drinking water treatment systems. In this paper, bench-scale experiments were performed to investigate the inhibition effect on Daphnia magna (D. magna) by controlling its phototactic behavior. The results showed that UVA had a negative effect on the phototaxis of D. magna, indicating an active movement away from light source, while blue light was positive in inducing phototactic behavior. The water quality could influence the phototactic behavior of D...
February 2018: Journal of Water and Health
https://www.readbyqxmd.com/read/29421845/effects-of-repeated-uva-irradiation-on-human-skin-fibroblasts-embedded-in-3d-tense-collagen-matrix
#14
Wongnapa Nakyai, Marion Tissot, Philippe Humbert, François Grandmottet, Jarupa Viyoch, Céline Viennet
Skin photoaging is caused by cumulative UVA exposure that leads to dermal matrix alterations associated with impaired fibroblast functions. In this study, we evaluated the effects of repeated UVA irradiation on mechanically stressed fibroblasts which were embedded in 3D tense collagen matrix. By comparison to 2D monolayer culture, we investigated the expressions of alpha smooth muscle actin (α-SMA) cytoskeleton and α2 subunit of integrin receptors, as well as the collagen metabolism, focusing to MMP-1 and collagen type I expressions...
February 8, 2018: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29420844/absorption-characteristics-and-quantum-yields-of-singlet-oxygen-generation-of-thioguanosine-derivatives
#15
Shoma Miyata, Takeshi Yamada, Tasuku Isozaki, Hideyuki Sugimura, Yao-Zhong Xu, Tadashi Suzuki
6-Thioguanine (1a) is considered to be photochemotherapeutic agents due to its specific characteristics of photosensitivity to UVA light and singlet molecular oxygen generation. To extend its phototherapeutic ability, two related thioguanines, 8-thioguanine (2a) and 6,8-dithioguanine (3a), have been designed and explored. Since the solubility of these thioguanines in dehydrated organic solvents is too poor to study, their tri-acetyl-protected ribonucleosides, i.e. 2',3',5'-tri-O-acetyl-6-thioguanosine (1c), 2',3',5'-tri-O-acetyl-8-thioguanosine (2c) and 2',3',5'-tri-O-acetyl-6,8-dithioguanosine (3c) were prepared and investigated...
February 8, 2018: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29420622/study-of-retina-and-choroid-biological-parameters-of-rhesus-monkeys-eyes-on-scleral-collagen-cross-linking-by-riboflavin-and-ultraviolet-a
#16
Mingshen Sun, Fengju Zhang, Bowen Ouyang, Mengmeng Wang, Yu Li, Xuan Jiao, Li Zhang, Ningli Wang
To evaluate ocular fundus biological changes after scleral collagen cross-linking (CXL) with riboflavin/ ultraviolet A (UVA) on rhesus monkeys in vivo by analyzing retina and choroid biological parameters. Six 3-year-old male rhesus monkeys (12 eyes) were observed in this study, with scleral CXL procedures applied on superior temporal equatorial sclera on random eyes of all rhesus. Optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) examination were performed before and 1 week, 1 month, 3 months and 6 months after CXL...
2018: PloS One
https://www.readbyqxmd.com/read/29419299/acid-dissociation-equilibrium-and-singlet-molecular-oxygen-quantum-yield-of-acetylated-6-8-dithioguanosine-in-aqueous-buffer-solution
#17
Shoma Miyata, Mina Hoshino, Tasuku Isozaki, Takeshi Yamada, Hideyuki Sugimura, Yao Zhong Xu, Tadashi Suzuki
2',3',5'-Tri-O-acetyl-6,8-dithioguanosine (taDTGuo) is a modified nucleoside of drug 6-thioguanine and further developed as a potential photochemotherapeutic agent due to its desirable properties of photosensitivity to UVA light and singlet molecular oxygen generation. The photochemical characteristics of taDTGuo under biological conditions (namely in aqueous solution) were intensively investigated by the steady-state absorption and emission, time-resolved near-infrared emission measurements, and quantum chemical calculations...
February 8, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29409483/real-world-refractive-outcomes-of-toric-intraocular-lens-implantation-in-a-united-kingdom-national-health-service-setting
#18
Kanmin Xue, Jasleen K Jolly, Sonia P Mall, Shreya Haldar, Paul H Rosen, Robert E MacLaren
BACKGROUND: With increasing availability of toric intraocular lenses (IOL) for cataract surgery, real-world refractive outcome data is needed to aid the counselling of patients regarding lens choice. We aim to assess the outcomes of toric intraocular lens use in the non-specialist environment of a typical United Kingdom NHS cataract service. METHODS: A retrospective cohort study conducted at the Oxford Eye Hospital, Oxford University Hospitals NHS Foundation Trust, UK...
February 6, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29408480/understanding-the-increased-aggregation-propensity-of-a-light-exposed-igg1-mab-using-hydrogen-exchange-mass-spectrometry-biophysical-characterization-and-structural-analysis
#19
Rupesh Bommana, Qing Chai, Christian Schöneich, William F Weiss, Ranajoy Majumdar
This work compares the conformational stability, backbone flexibility, and aggregation propensity of monomer and dimer fractions of an IgG1 monoclonal antibody (mAb) generated upon UVA light exposure for up to 72 hours collected by preparative size-exclusion chromatography (SEC), compared to unstressed control. UVA light exposure induced covalent aggregation, and fragmentation as measured by SEC, sodium dodecyl sulfate polyacrylamide gel electrophoresis and extensive oxidation of specific methionine residues (Met 257, Met 433, and Met 109) in both size fractions identified by reverse phase chromatography coupled to mass spectrometry...
January 30, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29406133/implementing-healthy-work-environment-standards-in-an-academic-workplace-an-update
#20
Rebecca B Harmon, Gina DeGennaro, Meg Norling, Christine Kennedy, Dorrie Fontaine
In 2005 the American Association of Critical Care Nurses defined six Healthy Work Environment (HWE) standards for the clinical setting (AACN, 2005), which were reaffirmed and expanded in 2016 (AACN, 2016). These clinical standards were adapted for use in the academic setting by Fontaine, Koh, and Carroll in 2012. The intention of this article is threefold: to present a revised version of the academic workplace standards which are appropriate for all School of Nursing (SON) employees, staff as well as faculty; to proposes the addition of a seventh standard, self-care, which provides the foundation for all standards; and to describe the continuing implementation of these seven standards at the University of Virginia School of Nursing (UVA SON)...
January 2018: Journal of Professional Nursing: Official Journal of the American Association of Colleges of Nursing
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