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https://www.readbyqxmd.com/read/29458159/strawberry-extracts-efficiently-counteract-inflammatory-stress-induced-by-the-endotoxin-lipopolysaccharide-in-human-dermal-fibroblast
#1
Massimiliano Gasparrini, Francesca Giampieri, Tamara Y Forbes-Hernandez, Sadia Afrin, Danila Cianciosi, Patricia Reboredo-Rodriguez, Alfonso Varela-Lopez, JiaoJiao Zhang, Josè L Quiles, Bruno Mezzetti, Stefano Bompadre, Maurizio Battino
A protracted pro-inflammatory state is the common denominator in the development, progression and complication of the common chronic diseases. Dietary antioxidants represent an efficient tool to counteract this inflammatory state. The aim of the present work was to evaluate the effects of strawberry extracts on inflammation evoked by E. Coli lipopolysaccharide in Human Dermal Fibroblast, by measuring reactive oxygen species production, apoptosis rate, antioxidant enzymes activity, mitochondria functionality and also investigating the molecular pathway involved in inflammatory and antioxidant response...
February 16, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29458056/alcohol-and-cv-health-jekyll-and-hyde-j-curves
#2
REVIEW
Evan L O'Keefe, James J Di Nicolantonio, James H O'Keefe, Carl J Lavie
A routine of light or moderate alcohol consumption (≤1 drink/day for women and 1 to 2 drinks/day for men) were associated with a lower risk for all-cause mortality, coronary artery disease (CAD), type 2 diabetes mellitus (T2D), heart failure (HF), and stroke. Conversely, heavy drinking, (>4 drinks/day) is associated with an increased risk for death and cardiovascular (CV) disease (CVD). Excessive alcohol intake trails behind only smoking and obesity among the 3 leading causes of premature deaths in the United States (US)...
February 16, 2018: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29457929/growth-of-the-james-cook-university-medical-program-maintaining-quality-continuing-the-vision-developing-postgraduate-pathways
#3
Tarun Sen Gupta, Peter Johnson, Roy Rasalam, Richard Hays
BACKGROUND: James Cook University (JCU) enrolled its first cohort of 64 in 2000 into a 6-year undergraduate medical program aimed at producing graduates capable of meeting the needs of North Queensland, Australia, with a focus on rural, remote, Indigenous and tropical health. The school's 1465 graduates over 13 cohorts who have a pattern of practice likely to meet the region's health needs. The JCU course was the first new Australian medical program for 25 years. The number of Australian medical schools has since doubled, while enrollments have almost tripled...
February 19, 2018: Medical Teacher
https://www.readbyqxmd.com/read/29457743/a-framework-for-complexity-in-palliative-care-a-qualitative-study-with-patients-family-carers-and-professionals
#4
Sophie Pask, Cathryn Pinto, Katherine Bristowe, Liesbeth van Vliet, Caroline Nicholson, Catherine J Evans, Rob George, Katharine Bailey, Joanna M Davies, Ping Guo, Barbara A Daveson, Irene J Higginson, Fliss Em Murtagh
BACKGROUND: Palliative care patients are often described as complex but evidence on complexity is limited. We need to understand complexity, including at individual patient-level, to define specialist palliative care, characterise palliative care populations and meaningfully compare interventions/outcomes. AIM: To explore palliative care stakeholders' views on what makes a patient more or less complex and insights on capturing complexity at patient-level. DESIGN: In-depth qualitative interviews, analysed using Framework analysis...
February 1, 2018: Palliative Medicine
https://www.readbyqxmd.com/read/29457585/training-nurses-in-a-competency-framework-to-support-adults-with-epilepsy-and-intellectual-disability-the-epaid-cluster-rct
#5
Howard Ring, James Howlett, Mark Pennington, Christopher Smith, Marcus Redley, Caroline Murphy, Roxanne Hook, Adam Platt, Nakita Gilbert, Elizabeth Jones, Joanna Kelly, Angela Pullen, Adrian Mander, Cam Donaldson, Simon Rowe, James Wason, Fiona Irvine
BACKGROUND: People with an intellectual (learning) disability (ID) and epilepsy have an increased seizure frequency, higher frequencies of multiple antiepileptic drug (AED) use and side effects, higher treatment costs, higher mortality rates and more behavioural problems than the rest of the population with epilepsy. The introduction of nurse-led care may lead to improvements in outcome for those with an ID and epilepsy; however, this has not been tested in a definitive clinical trial...
February 2018: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29457488/referral-patterns-and-implementation-costs-of-the-partners-in-recovery-initiative-in-gippsland-learnings-for-the-national-disability-insurance-scheme
#6
Anton N Isaacs, Kim Dalziel, Keith Sutton, Darryl Maybery
OBJECTIVE: The purpose of this paper is to provide some learnings for the NDIS from the referral pattern and cost of implementing the Partners in Recovery initiative of Gippsland. METHOD: Information on referral areas made for each consumer was collated from support facilitators. Cost estimates were determined using budget estimates, administrative costs and a literature review and are reported from a government perspective. RESULTS: Sixty-three per cent of all referrals were made to organisations that provided multiple types of services...
February 1, 2018: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/29457470/shared-decision-making-in-psychiatry-a-study-of-patient-attitudes
#7
Josie Nott, Aspen Mcintosh, Clare Taube, Mark Taylor
OBJECTIVES: Shared decision-making (SDM) is promoted as beneficial in mental healthcare, despite a dearth of supportive evidence. We aimed to obtain patients' perspective on SDM in a 'real world' hospital sample. METHODS: Structured validated questionnaires were used to examine SDM with regard to treatment choices, and whether SDM influences attitudes towards treatment. The Mini-Mental State Examination was used to assess decision-making capacity. RESULTS: A total of 109 individuals participated, with 60% reporting experiencing SDM...
February 1, 2018: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/29457256/innovation-in-values-based-public-health-nursing-student-selection-a-qualitative-evaluation-of-candidate-and-selection-panel-member-perspectives
#8
Caroline McGraw, Stephen Abbott, Judy Brook
OBJECTIVES: Values based recruitment emerges from the premise that a high degree of value congruence, or the extent to which an individual's values are similar to those of the health organization in which they work, leads to organizational effectiveness. The aim of this evaluation was to explore how candidates and selection panel members experienced and perceived innovative methods of values based public health nursing student selection. DESIGN AND SAMPLE: The evaluation was framed by a qualitative exploratory design involving semi-structured interviews and a group exercise...
February 19, 2018: Public Health Nursing
https://www.readbyqxmd.com/read/29457234/community-engagement-and-field-trials-of-genetically-modified-insects-and-animals
#9
Carolyn P Neuhaus
New techniques for the genetic modification of organisms are creating new strategies for addressing persistent public health challenges. For example, the company Oxitec has conducted field trials internationally-and has attempted to conduct field trials in the United States-of a genetically modified mosquito that can be used to control dengue, Zika, and some other mosquito-borne diseases. In 2016, a report commissioned by the National Academies of Sciences, Engineering, and Medicine discussed the potential benefits and risks of another strategy, using gene drives...
January 2018: Hastings Center Report
https://www.readbyqxmd.com/read/29457001/control-of-infectious-diseases-in-the-era-of-european-clinical-microbiology-laboratory-consolidation-new-challenges-and-opportunities-for-the-patient-and-for-public-health-surveillance
#10
Olivier Vandenberg, Zisis Kozlakidis, Jacques Schrenzel, Marc Jean Struelens, Judith Breuer
Many new innovative diagnostic approaches have been made available during the last 10 years with major impact on patient care and public health surveillance. In parallel, to enhance the cost-effectiveness of the clinical microbiology laboratories (CMLs), European laboratory professionals have streamlined their organization leading to amalgamation of activities and restructuring of their professional relationships with clinicians and public health specialists. Through this consolidation process, an operational model has emerged that combines large centralized clinical laboratories performing most tests on one high-throughput analytical platform connected to several distal laboratories dealing locally with urgent analyses at near point of care...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29456939/outcomes-of-bone-anchored-hearing-aid-implant-at-universiti-kebangsaan-malaysia-medical-centre-ukmmc
#11
Suhana Abdul Rahim, Bee-See Goh, Safinaz Zainor, Roslenda Abdul Rahman, Asma Abdullah
The cross sectional study was conducted in Universiti Kebangsaan Malaysia Medical Center (UKMMC), Malaysia from August 2012 to December 2013. All patients implanted with in UKMMC from December 2001 until December 2012 was included. Glasgow Benefit Inventory (GBI) questionnaires and UKMMC questionnaires were used as part of the assessment tool. The GBI is a scoring which measures the change in health status produced by surgical interventions. UKMMC questionnaires was invented by our department to assess questions related to social and life style of patients and also the cosmetic perspective Baha implant and other daily related activities...
March 2018: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/29456422/understanding-the-meaning-of-food-in-people-with-type-2-diabetes-living-in-northern-appalachia
#12
Elizabeth A Beverly, Marilyn D Ritholz, Linda A Wray, Ching-Ju Chiu, Emmy Suhl
Purpose: Food and eating convey memories and feelings and serve important functions in creating and maintaining relationships. Given the increasing rate of diabetes in the United States, research understanding the meaning of food may shed light on how patients negotiate everyday food choices while managing type 2 diabetes. The purpose of this qualitative study was to explore the meaning of food among adults with type 2 diabetes living in Northern Appalachia. Methods: In-depth, face-to-face interviews were conducted with type 2 diabetes patients...
February 2018: Diabetes Spectrum: a Publication of the American Diabetes Association
https://www.readbyqxmd.com/read/29456378/utilization-and-impact-of-electronic-and-print-media-on-the-patients-health-status-physicians-perspectives
#13
Sadia Shakeel, Shagufta Nesar, Najia Rahim, Wajiha Iffat, Hafiza Fouzia Ahmed, Mehwish Rizvi, Shazia Jamshed
Aims: Despite an increased popularity of print and electronic media applications, there is a paucity of data reflecting doctors' opinions regarding efficient utilization of these resources for the betterment of public health. Hence, this study aimed to investigate the perception of physicians toward the effect of electronic and print media on the health status of patients. Setting and Design: The current research is a cross-sectional study conducted from January 2015 to July 2015...
October 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/29456149/impact-of-a-universal-medication-schedule-on-rationalising-and-understanding-of-medication-a-randomised-controlled-trial
#14
Eimear McManus, Suzanne McCarthy, Raymond Carson, Laura J Sahm
BACKGROUND: Patients frequently encounter difficulty understanding their prescription drug labels. This problem is more common in patients with limited health literacy (HL). Patients are not always counselled on their medicines by their doctor or pharmacist, therefore this label can be an important source of information. OBJECTIVE: To assess the impact of a Universal Medication Schedule (UMS) on the knowledge and consolidation of a prescription drug regimen compared to standard pharmacy labelling...
February 10, 2018: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/29455724/adolescent-and-young-adult-male-mental-health-transforming-system-failures-into-proactive-models-of-engagement
#15
REVIEW
Simon M Rice, Rosemary Purcell, Patrick D McGorry
Adolescent and young adult men do poorly on indicators of mental health evidenced by elevated rates of suicide, conduct disorder, substance use, and interpersonal violence relative to their female peers. Data on global health burden clearly demonstrate that young men have a markedly distinct health risk profile from young women, underscoring different prevention and intervention needs. Evidence indicates that boys disconnect from health-care services during adolescence, marking the beginning of a progression of health-care disengagement and associated barriers to care, including presenting to services differently, experiencing an inadequate or poorly attuned clinical response, and needing to overcome pervasive societal attitudes and self-stigma to access available services...
March 2018: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/29455706/review-the-potential-of-seminal-fluid-mediated-paternal-maternal-communication-to-optimise-pregnancy-success
#16
J J Bromfield
Artificial insemination has been a landmark procedure in improving animal agriculture over the past 150 years. The utility of artificial insemination has facilitated a rapid improvement in animal genetics across agricultural species, leading to improvements of growth, health and productivity in poultry, swine, equine and cattle species. The utility of artificial insemination, as with all assisted reproductive technologies side-steps thousands of years of evolution that has led to the development of physiological systems to ensure the transmission of genetics from generation to generation...
February 19, 2018: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29455610/using-skype-to-support-remote-clinical-supervision-for-health-professionals-delivering-a-sustained-maternal-early-childhood-program-a-phenomenographical-study
#17
Tracey Bruce, Fiona Byrne, Lynn Kemp
BACKGROUND: Skype technology was implemented by the Australian Maternal Early Childhood Sustained Home-visiting (MECSH) Support Service as a tool for the remote provision of clinical supervision and case review processes for clinicians working in the MECSH program in Seoul, South Korea. Clinical supervision and case review are core components of MECSH-based programs to enhance critical thinking and support child and family health nurses to provide services for challenging and complex families within a sustained home visiting context...
February 19, 2018: Contemporary Nurse
https://www.readbyqxmd.com/read/29455536/resveratrol-s-hidden-hand-a-route-to-optical-detection-of-biomolecular-binding
#18
Subhojyoti Chatterjee, Seth Olsen, Ewan W Blanch, Feng Wang
Resveratrol (RSVL) is a stilbenoid phytoalexin with promised myriad health benefits predominantly attributed to the trans (E) diastereomeric form. A recent study has implicated the Z (cis) diastereomer in human health. This stereoisomer binds with high affinity to human tyrosyl-tRNA synthetase, initiating a downstream cascade that promotes the expression of genes associated with the cellular stress response. We discovered that the non-planar structure of cis-resveratrol conformer possesses certain chiral signals in its simulated vibrational circular dichroism (VCD) and Raman optical activity (ROA) spectra...
February 17, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29455523/sonchus-oleraceus-residue-improves-nutritive-and-health-promoting-value-%C3%A2-of-common-bean-phaseolus-vulgaris%C3%A2-%C3%A2-l-a-metabolic-study-%C3%A2
#19
Mahmoud O Hassan, Ahmed M Saleh, Hamada AbdElgawad
This study was conducted to evaluate the use of the phenolic-rich Sonchus ‎oleraceus residue as ‎an ‎environmentally safe approach to induce the nutritive and health-promoting values of ‎common bean ‎‎(Phaseolus vulgaris L. cv. Bronco). S. oleraceus shoot residue, at rates of 150 and 300 g m-2, has ‎improved soil ‎fertility via accumulation of soil macronutrients, ‎organic matter, organic carbon and ‎total phenolics. ‎The growth and yield of bean was significantly increased. Moreover, chemical ‎composition of ‎the treated seeds was significantly altered, whereas higher levels of total ‎antioxidant ‎capacity, ‎proteins, carbohydrates and most of the individual phenolic acids, ‎flavonoids, ‎vitamins, essential ‎amino acids, and unsaturated fatty acids were recorded...
February 17, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29455447/the-continuum-of-breast-cancer-care-and-outcomes-in-the-u-s-military-health-system-an-analysis-by-benefit-type-and-care-source
#20
Yvonne L Eaglehouse, Stephanie Shao, Wenyaw Chan, Derek Brown, Janna Manjelievskaia, Craig D Shriver, Kangmin Zhu
PURPOSE: This study investigates transition rates between breast cancer diagnosis, recurrence, and death by insurance benefit type and care source in U.S. Military Health System (MHS). METHODS: The MHS data repository and central cancer registry linked data were used to identify women aged 40-64 with histologically confirmed breast cancer between 2003 and 2007. Three-state continuous time Markov models were used to estimate transition rates and transition rate ratios (TRRs) by TRICARE benefit type (Prime or non-Prime) and care source (direct, purchased, or both), adjusted for demographic, tumor, and treatment variables...
February 17, 2018: Journal of Cancer Survivorship: Research and Practice
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