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https://www.readbyqxmd.com/read/29045525/clinical-benefit-of-systemic-treatment-in-patients-with-advanced-pancreatic-and-gastro-intestinal-neuroendocrine-tumours-according-to-esmo-mcbs-and-asco-framework
#1
L D de Hosson, L M van Veenendaal, Y Schuller, W T Zandee, W W de Herder, M E T Tesselaar, H J Klümpen, A M E Walenkamp
BackgroundAssessment of clinical benefit of systemic treatments of rare diseases including gastroenteropancreatic neuroendocrine tumors (GEP-NET) is challenging. Recently several tools have been developed to grade clinical benefit of cancer drugs. European Society for Medical Oncology (ESMO) has developed the ESMO Magnitude of Clinical Benefit Scale (ESMO-MCBS). The American Society of Clinical Oncology (ASCO) developed and revised the ASCO framework consisting of the Net Health Benefit (NHB) score juxtaposed against the costs of the treatment...
September 26, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29045253/gut-microbial-diversity-in-hiv-infection-post-combined-antiretroviral-therapy-a-key-target-for-prevention-of-cardiovascular-disease
#2
Mohamed El-Far, Cécile L Tremblay
PURPOSE OF REVIEW: Although the HIV-infected population is living longer and getting older under current treatment regimens, significant challenges arise for health management as the infection is associated with various premature aging phenotypes, particularly increased incidence of cardiovascular diseases (CVDs). Here we review the current understanding of HIV-related gut dysbiosis in association with CVD and advances in clinical trials aiming to restore gut microbial diversity. RECENT FINDING: Identification of a unique signature for gut dysbiosis in HIV infection between different cohorts remains challenging...
October 17, 2017: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/29045011/consumer-health-information-seeking-in-social-media-a-literature-review
#3
REVIEW
Yuehua Zhao, Jin Zhang
OBJECTIVE: The objective of this literature review was to summarise current research regarding how consumers seek health-related information from social media. Primarily, we hope to reveal characteristics of existing studies investigating the health topics that consumers have discussed in social media, ascertaining the roles social media have played in consumers' information-seeking processes and discussing the potential benefits and concerns of accessing consumer health information in social media...
October 17, 2017: Health Information and Libraries Journal
https://www.readbyqxmd.com/read/29044847/obesity-related-health-impacts-of-active-transport-policies-in-australia-a-policy-review-and-health-impact-modelling-study
#4
Vicki Brown, Marj Moodie, Linda Cobiac, Herrera Mantilla, Robert Carter
OBJECTIVE: To review Australian policies on active transport, defined as walking and cycling for utilitarian purposes. To estimate the potential health impact of achieving four active transport policy scenarios. METHODS: A policy review was undertaken, using key words to search government websites. Potential health benefits were quantified using a cohort simulation Markov model to estimate obesity and transport injury-related health effects of an increase in active transport...
October 18, 2017: Australian and New Zealand Journal of Public Health
https://www.readbyqxmd.com/read/29044832/understanding-acceptability-of-and-engagement-with-web-based-interventions-aiming-to-improve-quality-of-life-in-cancer-survivors-a-synthesis-of-current-research
#5
REVIEW
Teresa Corbett, Karmpaul Singh, Liz Payne, Katherine Bradbury, Claire Foster, Eila Watson, Alison Richardson, Paul Little, Lucy Yardley
PURPOSE: This review sought to summarize existing knowledge in order to inform the development of an online intervention that aims to improve quality of life after cancer treatment. METHODS: To inform our intervention, we searched for studies relating to web-based interventions designed to improve QoL in adults who have completed primary treatment for breast, prostate and colorectal cancer (as these are three of the most common cancers and impact a large number of cancer survivors)...
October 17, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/29044739/peripheral-intravenous-cannula-insertion-and-use-in-the-emergency-department-an-intervention-study
#6
Tracey Hawkins, Jaimi H Greenslade, Jessica Suna, Julian Williams, Matthew Jensen, Maria Donohue, Elizabeth Ho, Christopher Van Hise, Diana Egerton-Warburton, Louise Cullen
OBJECTIVES: To examine cannulation practice and effectiveness of a multi-modal intervention to reduce peripheral intravenous cannula (PIVC) insertion in emergency department (ED) patients. METHODS: A prospective before and after study and cost analysis was conducted at a single tertiary ED in Australia. Data were collected 24 hours a day for two weeks pre- and post-implementation of a multi-modal intervention. PIVC placement and utilization within 24 hours were evaluated in all eligible patients...
October 16, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29044670/the-effect-of-blue-light-blocking-spectacle-lenses-on-visual-performance-macular-health-and-the-sleep-wake-cycle-a%C3%A2-systematic-review-of-the-literature
#7
REVIEW
John G Lawrenson, Christopher C Hull, Laura E Downie
PURPOSE: Blue-blocking (BB) spectacle lenses, which attenuate short-wavelength light, are being marketed to alleviate eyestrain and discomfort when using digital devices, improve sleep quality and potentially confer protection from retinal phototoxicity. The aim of this review was to investigate the relative benefits and potential harms of these lenses. METHODS: We included randomised controlled trials (RCTs), recruiting adults from the general population, which investigated the effect of BB spectacle lenses on visual performance, symptoms of eyestrain or eye fatigue, changes to macular integrity and subjective sleep quality...
November 2017: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
https://www.readbyqxmd.com/read/29044612/is-there-an-occupational-therapy-employment-crisis-within-australia-an-investigation-into-two-consecutive-cohorts-of-occupational-therapy-graduates-from-a-single-victorian-university-identifying-trends-in-employment
#8
Pearse Fay, Lynne Adamson
BACKGROUND: Within the context of growing concerns about a potential oversupply of occupational therapist, this research examines when, where and how long new graduates take to gain employment and identifies influences upon the health and university systems. METHOD: A mixed method research design, using an online survey was adopted to investigate the topic. Two consecutive cohorts of graduates from a single university program were invited to participate. RESULTS: Seventy-five (58%) responses were received, with 63 (84%) currently employed in an occupational therapy role...
October 18, 2017: Australian Occupational Therapy Journal
https://www.readbyqxmd.com/read/29044555/openness-to-experience-and-adapting-to-change-cardiovascular-stress-habituation-to-change-in-acute-stress-exposure
#9
Páraic S Ó Súilleabháin, Siobhán Howard, Brian M Hughes
Underlying psychophysiological mechanisms of effect linking openness to experience to health outcomes, and particularly cardiovascular well-being, are unknown. This study examined the role of openness in the context of cardiovascular responsivity to acute psychological stress. Continuous cardiovascular response data were collected for 74 healthy young female adults across an experimental protocol, including differing counterbalanced acute stressors. Openness was measured via self-report questionnaire. Analysis of covariance revealed openness was associated with systolic blood pressure (SBP; p = ...
October 17, 2017: Psychophysiology
https://www.readbyqxmd.com/read/29044520/quercetin-protects-against-radiocontrast-medium-toxicity-in-human-renal-proximal-tubular-cells
#10
Michele Andreucci, Teresa Faga, Antonio Pisani, Raffele Serra, Domenico Russo, GIovambattista De Sarro, Ashour Michael
Radiocontrast media (RCM)-induced acute kidney injury (CI-AKI) is a major clinical problem whose, pathophysiology is not well understood. Direct toxic effects on renal cells, possibly mediated by reactive oxygen species, have been postulated as contributing to CI-AKI. We investigated the effect of quercetin on human renal proximal tubular (HK-2) cells treated with the radiocontrast medium (RCM) sodium diatrizoate. Quercetin is the most widely studied flavonoid, and the most abundant flavonol present in foods...
October 16, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29044374/human-and-livestock-trematode-infections-in-a-mobile-pastoralist-setting-at-lake-chad-added-value-of-a-one-health-approach-beyond-zoonotic-diseases-research
#11
Helena Greter, Annour A Batil, Bongo N Ngandolo, Idriss O Alfaroukh, Doumagoum D Moto, Jan Hattendorf, Jürg Utzinger, Jakob Zinsstag
Background: At Lake Chad in Central Africa, mobile pastoralists face economic losses due to livestock trematodiases. Fasciola gigantica and Schistosoma bovis-trematodes that affect livestock-share transmission ecology traits with Schistosoma haematobium and S. mansoni that cause human schistosomiasis. This project aimed at assessing treatment strategies and elucidating the predictive potential of human and livestock trematode infections. Methods: Schistosomiasis and fascioliasis were investigated concurrently in humans and cattle by repeated cross-sectional surveys...
June 1, 2017: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29044369/law-as-a-fixture-between-the-one-health-interfaces-of-emerging-diseases
#12
Alexandra L Phelan, Lawrence O Gostin
A One Health approach calls for multisectoral and multi-institutional cooperation and partnership across the interfaces of human, animal and ecosystem health risks. Without strong governance, these interfaces risk detaching, leaving gaps in capacities to prevent, detect and respond to emerging and persisting public health threats. As a crucial component of governance, law can act as the fixture between interfaces. We examine some of the many forms and foci of law and propose that the process of law-making, implementation and evaluation can provide a benefit for strengthening law as a fixture between One Health interfaces...
June 1, 2017: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29043986/potential-of-big-data-analytics-in-the-french-in-vitro-diagnostics-market
#13
Nicolas Dubois, Nicolas Garnier, Christophe Meune
The new paradigm of the big data raises many expectations, particularly in the field of health. Curiously, even though medical biology laboratories generate a great amount of data, the opportunities offered by this new field are poorly documented. For better understanding the clinical context of chronical disease follow-up, for leveraging preventive and/or personalized medicine, the contribution of big data analytics seems very promising. It is within this framework that we have explored to use data of a Breton group of laboratories of medical biology to analyze the possible contributions of their exploitation in the improvement of the clinical practices and to anticipate the evolution of pathologies for the benefit of patients...
October 18, 2017: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/29043949/arthroscopic-surgery-for-knee-osteoarthritis-impact-of-health-technology-assessment-in-germany
#14
Naomi Fujita-Rohwerder, Alric Rüther, Stefan Sauerland
OBJECTIVES: This study aims to describe how a negative reimbursement decision-based on the health technology assessment (HTA) report of a nondrug intervention-affects healthcare providers in Germany. METHODS: Knee arthroscopy was chosen as an example, because as of April 2016 this procedure is no longer reimbursed for osteoarthritis, but is still covered for other indications, including meniscal lesions. The exclusion followed an HTA report prepared by the Institute for Quality and Efficiency in Health Care (IQWiG)...
October 18, 2017: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/29043910/intersections-of-girl-child-marriage-and-family-planning-beliefs-and-use-qualitative-findings-from-ethiopia-and-india
#15
Katherine A McClendon, Lotus McDougal, Sankari Ayyaluru, Yemeserach Belayneh, Anand Sinha, Jay G Silverman, Anita Raj
Child marriage and subsequent early first birth is a considerable social, economic and health concern, and a pervasive practice in sub-Saharan Africa and South Asia. This study explores barriers and facilitators to family planning among women and girls, and their marital decision-makers subsequent to receipt of child marriage prevention programmes in Ethiopia and India. In-depth interviews with 128 women and girls who were married as minors or who cancelled or postponed marriage as minors and their marital decision-makers were analysed using content analysis...
October 18, 2017: Culture, Health & Sexuality
https://www.readbyqxmd.com/read/29043154/taking-care-of-suicidal-patients-with-new-technologies-and-reaching-out-means-in-the-post-discharge-period
#16
REVIEW
Giulia Falcone, Adele Nardella, Dorian A Lamis, Denise Erbuto, Paolo Girardi, Maurizio Pompili
Suicide is a global public health problem with over one million people dying by suicide each year worldwide. Research efforts have focused on developing and testing novel suicide prevention strategies employing recent technological advances. In order to provide a review regarding the role of new technologies (e.g., postcards/letters, text messages, crisis cards, telephone contacts, online interventions) in suicide prevention, we searched PubMed, ScienceDirect, ResearchGate, and Crisis to identify all papers in English from 1977 to 2016...
September 22, 2017: World Journal of Psychiatry
https://www.readbyqxmd.com/read/29043091/hope-help-for-people-with-money-employment-benefit-or-housing-problems-study-protocol-for-a-randomised-controlled-trial
#17
M C Barnes, A M Haase, A M Bard, J L Donovan, R Davies, S Dursley, J Potokar, N Kapur, K Hawton, R C O'Connor, W Hollingworth, C Metcalfe, D Gunnell
BACKGROUND: Self-harm and suicide increase in times of economic recession. Factors including job loss, austerity measures, financial difficulties and house repossession contribute to the risk. Vulnerable individuals commonly experience difficulties in navigating the benefits system and in accessing the available sources of welfare and debt advice, and this contributes to their distress. Our aim is to determine the feasibility and acceptability of a brief psychosocial intervention (the "HOPE" service) for people presenting to hospital emergency departments (ED) following self-harm or in acute distress because of financial, employment, or welfare (benefit) difficulties...
2017: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29043019/effects-of-livestock-grazing-on-rangeland-biodiversity-a-meta-analysis-of-grouse-populations
#18
REVIEW
Seth J Dettenmaier, Terry A Messmer, Torre J Hovick, David K Dahlgren
Livestock grazing affects over 60% of the world's agricultural lands and can influence rangeland ecosystem services and the quantity and quality of wildlife habitat, resulting in changes in biodiversity. Concomitantly, livestock grazing has the potential to be detrimental to some wildlife species while benefiting other rangeland organisms. Many imperiled grouse species require rangeland landscapes that exhibit diverse vegetation structure and composition to complete their life cycle. However, because of declining populations and reduced distributions, grouse are increasingly becoming a worldwide conservation concern...
October 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29042791/profile-of-sacubitril-valsartan-in-the-treatment-of-heart-failure-patient-selection-and-perspectives
#19
REVIEW
Srikanth Yandrapalli, Gabriela Andries, Medha Biswas, Sahil Khera
With an estimated prevalence of 5.8 million in the USA and over 23 million people worldwide, heart failure (HF) is growing in epidemic proportions. Despite the use of guideline-directed medical therapies such as angiotensin-converting enzyme inhibitors, beta-adrenergic blockers, angiotensin receptor blockers, and mineralocorticoid receptor antagonists for chronic systolic HF for almost two decades, HF remains a leading cause of morbidity, mortality, and health care expenditures. The Prospective Comparison of Angiotensin Receptor-Neprilysin Inhibitor with Angiotensin-Converting Enzyme Inhibitor to Determine Impact on Global Mortality and Morbidity in Heart Failure (PARADIGM-HF) trial provided compelling evidence for the cardiovascular and mortality benefit of sacubitril/valsartan when compared to enalapril in patients with heart failure and reduced ejection fraction (HFrEF)...
2017: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/29042495/impact-of-dietary-resistant-starch-on-the-human-gut-microbiome-metaproteome-and-metabolome
#20
Tanja V Maier, Marianna Lucio, Lang Ho Lee, Nathan C VerBerkmoes, Colin J Brislawn, Jörg Bernhardt, Regina Lamendella, Jason E McDermott, Nathalie Bergeron, Silke S Heinzmann, James T Morton, Antonio González, Gail Ackermann, Rob Knight, Katharina Riedel, Ronald M Krauss, Philippe Schmitt-Kopplin, Janet K Jansson
Diet can influence the composition of the human microbiome, and yet relatively few dietary ingredients have been systematically investigated with respect to their impact on the functional potential of the microbiome. Dietary resistant starch (RS) has been shown to have health benefits, but we lack a mechanistic understanding of the metabolic processes that occur in the gut during digestion of RS. Here, we collected samples during a dietary crossover study with diets containing large or small amounts of RS. We determined the impact of RS on the gut microbiome and metabolic pathways in the gut, using a combination of "omics" approaches, including 16S rRNA gene sequencing, metaproteomics, and metabolomics...
October 17, 2017: MBio
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