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https://www.readbyqxmd.com/read/29908361/incidence-of-upper-and-lower-gastrointestinal-bleeding-in-new-users-of-low-dose-aspirin
#1
Lucía Cea Soriano, Angel Lanas, Montse Soriano-Gabarró, Luis A García Rodríguez
BACKGROUND & AIMS: There are few data on the incidence of upper and lower gastrointestinal bleeding (UGIB and LGIB) from observational studies of low-dose aspirin users. We aimed to estimate incidence rates of UGIB and LGIB in a large cohort of new users of low-dose aspirin in the United Kingdom, with sub-analyses of hospitalization status and fatalities. METHODS: We performed a population-based study of 199,079 new users of low-dose aspirin (median age, 64...
June 13, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29908276/interactions-of-quercetin-curcumin-epigallocatechin-gallate-and-folic-acid-with-gelatin
#2
Tingting Yang, Huiru Yang, Yan Fan, Bafang Li, Hu Hou
Some small bioactive molecules from food show the potential health benefits, but with poor chemical stability and bioavailability. The interactions between small molecules and gelatin were investigated. Fluorescence experiments demonstrated that the bimolecular quenching constants (kq ) of complexes (gelatin-quercetin, gelatin-curcumin, gelatin-epigallocatechin gallate, gelatin-folic acid) were 3.7 × 1012  L·mol-1 ·s-1 , 1.4 × 1012  L·mol-1 ·s-1 , 2.7 × 1012  L·mol-1 ·s-1 and 8.5 × 1012  L·mol-1 ·s-1 , indicating that fluorescence quenching did not arise from a dynamical mechanism, but from gelatin-small molecules binding...
June 13, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29907977/melatonin-induces-mechanisms-of-brain-resilience-against-neurodegeneration
#3
Rubén Corpas, Christian Griñán-Ferré, Verónica Palomera-Ávalos, David Porquet, Pablo García de Frutos, Silvia M Franciscato Cozzolino, Eduard Rodríguez-Farré, Mercè Pallàs, Coral Sanfeliu, Bárbara R Cardoso
Melatonin is an endogenous pleiotropic molecule which orchestrates regulatory functions and protective capacity against age-related ailments. The increase in circulating levels of melatonin through dietary supplements intensifies its health benefits. Investigations in animal models have shown that melatonin protects against Alzheimer's disease (AD)-like pathology, although clinical studies have not been conclusive. We hypothesized that melatonin induces changes in the brain that prevent or attenuate AD by increasing resilience...
June 15, 2018: Journal of Pineal Research
https://www.readbyqxmd.com/read/29907884/availability-and-affordability-of-essential-medicines-implications-for-global-diabetes-treatment
#4
REVIEW
David Beran, Margaret Ewen, Kasia Lipska, Irl B Hirsch, John S Yudkin
PURPOSE OF REVIEW: The purpose of this review is to highlight the key issues with regard to the value, affordability, and availability of diabetes treatments. RECENT FINDINGS: Many of the medicines needed to manage diabetes are available as generics and, if purchased appropriately, can be made affordable to many individuals and systems. With new treatments for diabetes, additional costs to individuals and systems need to be assessed in terms of added clinical benefit and financial impact...
June 16, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/29907557/effective-behavioral-changes-through-a-digital-mhealth-app-exploring-the-impact-of-hedonic-well-being-psychological-empowerment-and-inspiration
#5
Yuting Lin, Carina Tudor-Sfetea, Sarim Siddiqui, Yusuf Sherwani, Maroof Ahmed, Andreas B Eisingerich
BACKGROUND: New mobile health (mHealth) software apps are emerging and are providing the foundation to radically transform the practice and reach of medical research and care. For this study we collaborated with Quit Genius, a cognitive behavioral therapy (CBT) based mHealth app that helps users quit smoking, to explore the effective design of a digital mHealth app; one that delivers important benefits to its users and helps them change their behaviors for a healthier lifestyle. OBJECTIVE: The specific aims of this study were to (1) explore the key role of CBT program progress, (2) examine the gamification design app elements that deliver significant benefits (ie, empowerment, well-being, inspiration) to users, (3) explore the effectiveness of these app elements to help users quit smoking or reduce the number of cigarettes smoked, and (4) identify and describe any potential drivers and hindrances arising from the app design elements...
June 15, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29907556/veterans-perspectives-on-fitbit-use-in-treatment-for-post-traumatic-stress-disorder-an-interview-study
#6
Ada Ng, Madhu Reddy, Alyson K Zalta, Stephen M Schueller
BACKGROUND: The increase in availability of patient data through consumer health wearable devices and mobile phone sensors provides opportunities for mental health treatment beyond traditional self-report measurements. Previous studies have suggested that wearables can be effectively used to benefit the physical health of people with mental health issues, but little research has explored the integration of wearable devices into mental health care. As such, early research is still necessary to address factors that might impact integration including patients' motivations to use wearables and their subsequent data...
June 15, 2018: JMIR Mental Health
https://www.readbyqxmd.com/read/29907467/measuring-health-related-benefit-and-quality-of-care-in-oral-and-maxillofacial-surgery-british-association-of-oral-and-maxillofacial-surgeons-outcomes-project
#7
EDITORIAL
J McMahon, F Puglia, I Martin, D Mitchell, S Dover, R Bentley, S Parmar, A T Smith, C Kerawala, I Holland
No abstract text is available yet for this article.
June 12, 2018: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/29907381/implementation-of-the-frailty-index-in-hospitalized-older-patients-results-from-the-reposi-register
#8
M Cesari, C Franchi, L Cortesi, A Nobili, I Ardoino, P M Mannucci
BACKGROUND: Frailty is a state of increased vulnerability to stressors, associated to poor health outcomes. The aim of this study was to design and introduce a Frailty Index (FI; according to the age-related accumulation of deficit model) in a large cohort of hospitalized older persons, in order to benefit from its capacity to comprehensively weight the risk profile of the individual. METHODS: Patients aged 65 and older enrolled in the REPOSI register from 2010 to 2016 were considered in the present analyses...
June 12, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29907335/trial-protocol-the-use-of-mindfulness-based-intervention-for-improving-bracing-compliance-for-adolescent-idiopathic-scoliosis-patients-protocol-for-a-randomised-controlled-trial
#9
Benjamin Hon Kei Yip, Xue Li, Christine Hiu Yan Leung, Ting Gao, Vincent Chi Ho Chung, Fiona Wai Ping Yu, Tsz Ping Lam, Jack Chun Yiu Cheng, Samuel Yeung Shan Wong
INTRODUCTION: Adolescent idiopathic scoliosis (AIS) is the most prevalent deforming orthopaedic condition; it causes significant disability when spinal curves progress beyond 45deg. Bracing is the primary treatment prescribed for adolescents with an immature skeleton who have spinal curves between 25 and 45deg. New evidence suggests that compliance with bracing significantly decreases the progression of high-risk curves to the threshold for surgery. Nonetheless, bracing is a stressful experience...
June 12, 2018: Journal of Physiotherapy
https://www.readbyqxmd.com/read/29907334/risk-and-benefits-of-bubble-continuous-positive-airway-pressure-for-neonatal-and-childhood-respiratory-diseases-in-low-and-middle-income-countries
#10
REVIEW
Osayame A Ekhaguere, Amsa B Mairami, Haresh Kirpalani
Over 80% of the global burden of childhood deaths occur in Low- and Middle-Income Countries (LMIC). Of the leading causes of death, respiratory failure is common to the top three. Bubble Continuous Positive Airway Pressure (bCPAP) is a standard therapy considered safe and cost effective in high resource settings. Although high-quality trials from LMIC are few, pooled available trial data considered alongside studies from high-income countries suggest that bCPAP: (i) reduces mortality; (ii) reduces the need for mechanical ventilation; and (iii) prevents extubation failure...
May 4, 2018: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/29907087/factors-associated-with-missed-assessments-in-a-2-year-longitudinal-study-of-acute-respiratory-distress-syndrome-survivors
#11
Sara E Heins, Amy W Wozniak, Elizabeth Colantuoni, Kristin A Sepulveda, Pedro A Mendez-Tellez, Cheryl Dennison-Himmelfarb, Dale M Needham, Victor D Dinglas
BACKGROUND: To evaluate participant-related variables associated with missing assessment(s) at follow-up visits during a longitudinal research study. METHODS: This is a prospective, longitudinal, multi-site study of 196 acute respiratory distress syndrome (ARDS) survivors. More than 30 relevant sociodemographic, physical status, and mental health variables (representing participant characteristics prior to ARDS, at hospital discharge, and at the immediately preceding follow-up visit) were evaluated for association with missed assessments at 3, 6, 12, and 24-month follow-up visits (89-95% retention rates), using binomial logistic regression...
June 15, 2018: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29906622/effects-of-dietary-soybean-lecithin-on-growth-performance-blood-chemistry-and-immunity-in-juvenile-stellate-sturgeon-acipenser-stellatus
#12
Fatemeh Jafari, Naser Agh, Farzaneh Noori, Amir Tokmechi, Enric Gisbert
An eleven weeks feeding trial was conducted to determine the effects of different levels of dietary soybean lecithin (SBL) on growth performance, blood chemistry and immunity in juvenile stellate sturgeon (Acipenser stellatus). Fish were fed seven isoproteic (44% crude protein) and isolipidic (17% crude fat) diets containing graded levels of SBL: 0 (control), 1, 2, 4, 6, 8 and 10%. Results showed that dietary SBL supplementation significantly improved the final body weight (BW) and weight gain (WG). Fish fed 6% SBL showed the highest BW and WG values in comparison to fish fed the control diet (P < 0...
June 12, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29906471/self-selection-of-plant-bioactive-compounds-by-sheep-in-response-to-challenge-infection-with-haemonchus-contortus
#13
Cesar H E C Poli, Kara J Thornton-Kurth, Jerrad F Legako, Carolina Bremm, Viviane S Hampel, Jeffery Hall, Ignacio R Ipharraguerre, Juan J Villalba
Plant bioactives can potentially benefit herbivores through their effects on health and nutrition. The objective of this study was to determine the importance of polyphenols and terpenes on the ability of lambs to self-select these compounds when challenged by a parasitic infection and the subsequent impact on their health and productivity. Thirty-five lambs were housed in individual pens and assigned to five treatment groups (7 animals/group), where they received: 1) A basal diet of beet pulp:soybean meal (90:10) (CONTROL); 2) The same diet, but containing 0...
June 12, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29906421/effectiveness-of-pulmonary-rehabilitation-in-patients-with-chronic-obstructive-pulmonary-disease-with-different-degrees-of-static-lung-hyperinflation
#14
Michiel J E G W Vanfleteren, Maud Koopman, Martijn A Spruit, Herman-Jan Pennings, Frank Smeenk, Willem Pieters, Jan J A M van den Bergh, Arent-Jan Michels, Emiel F M Wouters, Miriam T J Groenen, Frits M E Franssen, Lowie E G W Vanfleteren
OBJECTIVE: To evaluate the effect of pulmonary rehabilitation (PR) on exercise performance and quality of life in patients with chronic obstructive pulmonary disease (COPD) with different degrees of static lung hyperinflation (LH). DESIGN: Retrospective cohort study. SETTING: Pulmonary Rehabilitation Network. PARTICIPANTS: A cohort of 1981 patients with COPD (55% males; age: 66.8 ± 9.3y; FEV1%: 50.7 ± 19.5; RV%: 163...
June 12, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29905932/quality-and-consumer-acceptance-of-berry-fruit-pomace-fortified-specialty-mustard
#15
Lissa Davis, Jooyeoun Jung, Ann Colonna, Aimee Hasenbeck, Virginia Gouw, Yanyun Zhao
Blueberry pomace (BP) and cranberry pomace (CP) are good sources of dietary fiber and phenolics. This study aimed to develop berry fruit pomace (FP)-fortified specialty mustard with elevated bioactive compounds and ascertain consumer acceptance of a new product. Wet BP and CP were ground and incorporated into Dijon-style mustard at concentrations of 15%, 20%, and 25% (w/w). Total dietary fiber (TDF), total phenolic content (TPC), and radical scavenging activity (RSA) were evaluated for samples obtained from both chemical extraction (CE) and simulated gastrointestinal digestion (SGD)...
June 15, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29905855/public-private-partnerships-in-practice-collaborating-to-improve-health-finance-policy-in-ghana-and-kenya
#16
Lauren Suchman, Elizabeth Hart, Dominic Montagu
Social health insurance (SHI), one mechanism for achieving universal health coverage, has become increasingly important in low- and middle-income countries (LMICs) as they work to achieve this goal. Although small private providers supply a significant proportion of healthcare in LMICs, integrating these providers into SHI systems is often challenging. Public-private partnerships in health are one way to address these challenges, but we know little about how these collaborations work, how effectively, and why...
June 13, 2018: Health Policy and Planning
https://www.readbyqxmd.com/read/29905647/the-associations-between-falls-fall-injuries-and-labor-market-outcomes-among-u-s-workers-65-years-and-older
#17
Kenneth Scott, Gwenith G Fisher, Anna E Barón, Emile Tompa, Lorann Stallones, Carolyn DiGuiseppi
OBJECTIVE: To examine whether falls are associated with the subsequent ability to work among workers 65 years and older. METHODS: This longitudinal cohort study followed older workers enrolled in the Health and Retirement Study. Outcomes included time to health-related work limitation and to labor force exit. RESULTS: After adjustment multiple falls with or without a medically-treated injury were associated with time to limitation (HR = 1...
June 13, 2018: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29905584/human-papilloma-virus-and-the-nurse-s-role-in-education-and-prevention
#18
Jennifer S Sherry, Sandra K Collins, Richard C McKinnies, Anthony Fleege, Marcea L Walter
In the United States, an estimated 20 million people, or 15% of the population, are currently infected with human papilloma virus (HPV). The prevalence of HPV is increasing in females aged 14 to 24 years. Assessing allied health students' knowledge, attitudes, and behaviors regarding HPV was performed using a 34-question survey. The survey was in four sections: general information, measuring knowledge of HPV and the vaccine, HPV vaccine, and HPV screening and diagnosis. Physicians were noted by 31.6% of the participants as the first individual who gave them information about HPV...
June 14, 2018: Health Care Manager
https://www.readbyqxmd.com/read/29905523/self-referrals-versus-physician-referrals-what-new-patient-visit-yields-an-actual-surgical-case
#19
Eric Z Herring, Matthew R Peck, Caroline E Vonck, Gabriel A Smith, Thomas E Mroz, Michael P Steinmetz
OBJECTIVE Spine surgeons in the United States continue to be overwhelmed by an aging population, and patients are waiting weeks to months for appointments. With a finite number of clinic visits per surgeon, analysis of referral sources needs to be explored. In this study, the authors evaluated patient referrals and their yield for surgical volume at a tertiary care center. METHODS This is a retrospective study of new patient visits by the spine surgery group at the Cleveland Clinic Center for Spine Health from 2011 to 2016...
June 15, 2018: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29905398/comparison-of-fixed-versus-traditional-weight-based-dosing-of-rasburicase-in-a-pediatric-population
#20
Dimitrios A Savva, Nicole Herrera, Radha Rohatgi
BACKGROUND: The American Society of Clinical Oncology guidelines recommend rasburicase for the treatment of pediatric patients with hyperuricemia at risk of tumor lysis syndrome (TLS) using a weight-based dose of 0.1-0.2 mg/kg once daily for 1-7 days. However, there has been a trend in practice due to recent data showing benefit using a fixed-dose approach. The purpose of this study was to evaluate the efficacy and safety between fixed and weight-based dosing of rasburicase in a pediatric population...
June 15, 2018: Pediatric Blood & Cancer
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