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https://www.readbyqxmd.com/read/27651603/falope-rings-or-modified-pomeroy-s-technique-for-concurrent-tubal-sterilization
#1
Leelavathi Basava, Priyankur Roy, V Anusha Priya, Shubhashri Srirama
INTRODUCTION: Sterilization at caesarean section is usually performed by the modified Pomeroy's technique. Application of Falope rings and Filshie clips may also be used for tubal sterilization at caesarean section, and these techniques are also used during laparoscopy or minilaparotomy. OBJECTIVES: The main objective of the study was to evaluate the failure rates, complications, technical difficulties and reversibility of the Falope ring application for tubal sterilization as compared to the traditional modified Pomeroy's technique used during caesarean sections...
October 2016: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/27494193/techniques-for-the-interruption-of-tubal-patency-for-female-sterilisation
#2
REVIEW
Theresa A Lawrie, Regina Kulier, Juan Manuel Nardin
BACKGROUND: This is an update of a review that was first published in 2002. Female sterilisation is the most popular contraceptive method worldwide. Several techniques exist for interrupting the patency of fallopian tubes, including cutting and tying the tubes, damaging the tube using electric current, applying clips or silicone rubber rings, and blocking the tubes with chemicals or tubal inserts. OBJECTIVES: To compare the different tubal occlusion techniques in terms of major and minor morbidity, failure rates (pregnancies), technical failures and difficulties, and women's and surgeons' satisfaction...
2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27268068/results-of-a-phase-ii-study-of-thalidomide-and-azacitidine-in-patients-with-clinically-advanced-myelodysplastic-syndromes-mds-chronic-myelomonocytic-leukemia-cmml-and-low-blast-count-acute-myeloid-leukemia-aml
#3
Melita Kenealy, Nigel Patton, Robin Filshie, Andrew Nicol, Shir-Jing Ho, Mark Hertzberg, Tony Mills, Ian Prosser, Emma Link, Linda Cowan, Diana Zannino, John F Seymour
Single agent azacitidine or immunomodulatory drugs are effective in myelodysplastic syndrome (MDS), with differing target mechanisms and toxicities. Objectives of this ALLG MDS3 study in clinically advanced MDS, AMML and low blast AML were to establish safety, response and quality of life of azacitidine and thalidomide. Patients received azacitidine (75mg/m(2)/d sc 7days every 28 days), and oral thalidomide up to 100mg/d for maximum 12months. Eighty patients registered; median age 68 years (range 42-82), 49% IPSS int2-high...
June 7, 2016: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/27156228/a-randomised-study-comparing-the-effectiveness-of-acupuncture-or-morphine-versus-the-combination-for-the-relief-of-dyspnoea-in-patients-with-advanced-non-small-cell-lung-cancer-and-mesothelioma
#4
A Minchom, R Punwani, J Filshie, J Bhosle, K Nimako, J Myerson, R Gunapala, S Popat, M E R O'Brien
BACKGROUND: Dyspnoea is one of the commonest symptoms of lung cancer. Opioids can reduce dyspnoea. This study investigates acupuncture for relief of breathlessness in lung cancer. METHODS: We performed a single-centre, randomised phase II study of 173 patients with non-small cell lung cancer or mesothelioma with dyspnoea score of ≥4 on visual analogue scale (VAS). Randomisation was to acupuncture alone (A), morphine alone (M) or both (AM). Acupuncture was administered at upper sternal, thoracic paravertebral, trapezius trigger points and LI4...
July 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/26685769/use-of-arsenic-trioxide-in-remission-induction-and-consolidation-therapy-for-acute-promyelocytic-leukaemia-in-the-australasian-leukaemia-and-lymphoma-group-allg-apml4-study-a-non-randomised-phase-2-trial
#5
Harry J Iland, Marnie Collins, Ken Bradstock, Shane G Supple, Alberto Catalano, Mark Hertzberg, Peter Browett, Andrew Grigg, Frank Firkin, Lynda J Campbell, Amanda Hugman, John Reynolds, Juliana Di Iulio, Campbell Tiley, Kerry Taylor, Robin Filshie, Michael Seldon, John Taper, Jeff Szer, John Moore, John Bashford, John F Seymour
BACKGROUND: Initial treatment of acute promyelocytic leukaemia traditionally involves tretinoin (all-trans retinoic acid) combined with anthracycline-based risk-adapted chemotherapy, with arsenic trioxide being the treatment of choice at relapse. To try to reduce the relapse rate, we combined arsenic trioxide with tretinoin and idarubicin in induction therapy, and used arsenic trioxide with tretinoin as consolidation therapy. METHODS: Patients with previously untreated genetically confirmed acute promyelocytic leukaemia were eligible for this study...
September 2015: Lancet Haematology
https://www.readbyqxmd.com/read/26464106/dose-reduced-fludarabine-cyclophosphamide-and-rituximab-is-well-tolerated-in-older-patients-with-chronic-lymphocytic-leukemia-and-has-preserved-therapeutic-efficacy
#6
Thomas E Lew, Chan Y Cheah, Dennis A Carney, H Miles Prince, Max Wolf, Ali Bazargan, E Henry Januszewicz, Robin Filshie, David Westerman, John F Seymour, Constantine S Tam
Despite its efficacy in prospective trials, full dose fludarabine, cyclophosphamide and rituximab (FCR) may be too toxic for elderly patients with chronic lymphocytic leukemia (CLL) in clinical practice. We retrospectively reviewed the impact of dose reductions in FCR therapy on the outcomes of 42 consecutive patients aged 65-87 (median 72) years. Despite a median cumulative fludarabine dose reduction of 50% from full dose, the objective response and complete response rates were 86% and 38% respectively (frontline 94%/59%; previously treated 80%/24%)...
May 2016: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/26343930/techniques-for-the-interruption-of-tubal-patency-for-female-sterilisation
#7
REVIEW
Theresa A Lawrie, Regina Kulier, Juan Manuel Nardin
BACKGROUND: This is an update of a review that was first published in 2002. Female sterilisation is the most popular contraceptive method worldwide. Several techniques exist for interrupting the patency of fallopian tubes, including cutting and tying the tubes, damaging the tube using electric current, applying clips or silicone rubber rings, and blocking the tubes with chemicals or tubal inserts. OBJECTIVES: To compare the different tubal occlusion techniques in terms of major and minor morbidity, failure rates (pregnancies), technical failures and difficulties, and women's and surgeons' satisfaction...
2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26343137/filshie-clip-migration-with-multiple-groin-hernias-a-case-report
#8
Alison Michelle Mumme, Jamie Cham
INTRODUCTION: Tubal occlusion is a common form of contraception. Filshie clips have been widely used for tubal occlusion since their introduction. Reports of Filshie clip migration are rare. We describe what we believe to be the first reported case of a patient with multiple groin hernias associated with migration of a Filshie clip. CASE PRESENTATION: We report the case of 56-year-old Caucasian woman who presented with a tender right groin lump. She had undergone a right-sided inguinal hernia repair 3 years earlier...
September 7, 2015: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/26134364/imatinib-induced-gastric-antral-vascular-ectasia-in-three-patients-with-chronic-myeloid-leukaemia
#9
Jeremy Ong, David Yeung, Robin Filshie, Timothy P Hughes, Harshal Nandurkar
Imatinib is generally well tolerated, but gastric antral vascular ectasia (GAVE) remains a rare but significant complication of imatinib therapy. Whilst this complication has been described in other disease settings, only one other case of GAVE has been reported in a chronic myeloid leukaemia (CML) patient receiving imatinib. Herein, we present three CML patients with GAVE complicating imatinib therapy. In all cases, GAVE resolved only with cessation of imatinib. This confirms a causal relationship between GAVE and imatinib...
November 2015: International Journal of Hematology
https://www.readbyqxmd.com/read/25519749/tidel-ii-first-line-use-of-imatinib-in-cml-with-early-switch-to-nilotinib-for-failure-to-achieve-time-dependent-molecular-targets
#10
David T Yeung, Michael P Osborn, Deborah L White, Susan Branford, Jodi Braley, Alan Herschtal, Michael Kornhauser, Samar Issa, Devendra K Hiwase, Mark Hertzberg, Anthony P Schwarer, Robin Filshie, Christopher K Arthur, Yiu Lam Kwan, Judith Trotman, Cecily J Forsyth, John Taper, David M Ross, Jennifer Beresford, Constantine Tam, Anthony K Mills, Andrew P Grigg, Timothy P Hughes
The Therapeutic Intensification in De Novo Leukaemia (TIDEL)-II study enrolled 210 patients with chronic phase chronic myeloid leukemia (CML) in two equal, sequential cohorts. All started treatment with imatinib 600 mg/day. Imatinib plasma trough level was performed at day 22 and if <1000 ng/mL, imatinib 800 mg/day was given. Patients were then assessed against molecular targets: BCR-ABL1 ≤10%, ≤1%, and ≤0.1% at 3, 6, and 12 months, respectively. Cohort 1 patients failing any target escalated to imatinib 800 mg/day, and subsequently switched to nilotinib 400 mg twice daily for failing the same target 3 months later...
February 5, 2015: Blood
https://www.readbyqxmd.com/read/25454968/receiving-or-not-receiving-acupuncture-in-a-trial-the-experience-of-participants-recovering-from-breast-cancer-treatment
#11
RANDOMIZED CONTROLLED TRIAL
Mackereth Peter, Bardy Joy, Filshie Jacqueline, Finnegan-John Jennifer, Molassiotis Alexander
OBJECTIVE: To explore the experience of breast cancer patients who either received acupuncture or were allocated to the control group. METHODS: Focus group/interviews nested within our multi-site randomised controlled trial. Participants were recruited from the standard care and experimental arm. The interviews/focus groups were transcribed and analysed thematically. RESULTS: Of the 302 eligible participants 13% (n = 40) contributed to the focus groups/interviews, across three study sites in the UK...
November 2014: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/25138588/ibrutinib-inhibits-collagen-mediated-but-not-adp-mediated-platelet-aggregation
#12
S Kamel, L Horton, L Ysebaert, M Levade, K Burbury, S Tan, M Cole-Sinclair, J Reynolds, R Filshie, S Schischka, A Khot, S Sandhu, M J Keating, H Nandurkar, C S Tam
The BTK (Bruton's tyrosine kinase) inhibitor ibrutinib is associated with an increased risk of bleeding. A previous study reported defects in collagen- and adenosine diphosphate (ADP)-dependent platelet responses when ibrutinib was added ex vivo to patient samples. Whereas the collagen defect is expected given the central role of BTK in glycoprotein VI signaling, the ADP defect lacks a mechanistic explanation. In order to determine the real-life consequences of BTK platelet blockade, we performed light transmission aggregometry in 23 patients receiving ibrutinib treatment...
April 2015: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/25105536/sorafenib-priming-may-augment-salvage-chemotherapy-in-relapsed-and-refractory-flt3-itd-positive-acute-myeloid-leukemia
#13
K D Cummins, S M Jane, S Ninkovic, S Nikovic, A Bazargan, R Filshie, G Sutrave, M Hertzberg, A Scott, S Lane, C K Yannakou, D Ritchie, J D'Rozario, J Black, K Bavishi, A Wei
No abstract text is available yet for this article.
2014: Blood Cancer Journal
https://www.readbyqxmd.com/read/24844361/an-imatinib-only-window-followed-by-imatinib-and-chemotherapy-for-philadelphia-chromosome-positive-acute-leukemia-long-term-results-of-the-cmlall1-trial
#14
Jason D Lickliter, Kerry Taylor, Jeff Szer, Andrew Grigg, Christopher Arthur, Timothy P Hughes, Simon Durrant, Robin Filshie, Ian Irving, Michael Seldon, Jennifer Ellacott, Andrew W Boyd, James D'Rozario, Kim Rooney, Kevin Lynch, Ken Bradstock
We report long-term results in 40 patients with Philadlephia chromosome-positive (Ph+) acute leukemia who received an imatinib monotherapy window to evaluate in vivo effects on BCR-ABL signaling prior to induction chemotherapy. The first 25 patients (cohort 1) received the LALA-94 protocol without further imatinib (newly diagnosed Ph+ acute lymphoblastic leukemia [ALL]) or induction chemotherapy followed by single-agent imatinib. Subsequent patients (cohort 2) continued imatinib concurrently with either LALA-94 (newly diagnosed Ph + ALL) or other intensive chemotherapy regimens...
March 2015: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/24560346/female-sterilization-and-refertilization
#15
Anneloes N J Huijgens, Céline M J G Lardenoije, Helen J M M Mertens
OBJECTIVE: To analyze data on sterilization and refertilization procedures that took place at Orbis Medical Center in Sittard, a hospital in the south of the Netherlands. STUDY DESIGN: Retrospective cohort study of surgical tubal sterilizations performed on 966 patients for contraception between 2002 and 2011, and of 19 patients who underwent refertilization between 2002 and 2012. The main outcome measures were complications and failure rates of sterilization, motives for refertilization and pregnancy rates after refertilization...
April 2014: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/23809725/feasibility-of-early-discharge-strategies-for-neutropenic-fever-outcomes-of-a-victorian-organisational-readiness-assessment-and-pilot
#16
S Lingaratnam, A Mellerick, L J Worth, M Green, S Guy, S Kirsa, M Slavin, W Renwick, R Filshie, K A Thursky
BACKGROUND: Although Australian consensus guidelines support the use of ambulatory care strategies for management of adult patients with low-risk neutropenic fever (NF), few centres have successfully implemented viable programmes. AIMS: To study the feasibility of an early discharge programme for adult patients with low-risk NF and assess organisational factors likely to influence successful implementation across participating Victorian hospitals. METHODS: Four hospitals participated in an organisational readiness assessment preceding selection of a pilot site for programme implementation...
September 2013: Internal Medicine Journal
https://www.readbyqxmd.com/read/23704092/safety-and-efficacy-of-imatinib-cessation-for-cml-patients-with-stable-undetectable-minimal-residual-disease-results-from-the-twister-study
#17
MULTICENTER STUDY
David M Ross, Susan Branford, John F Seymour, Anthony P Schwarer, Christopher Arthur, David T Yeung, Phuong Dang, Jarrad M Goyne, Cassandra Slader, Robin J Filshie, Anthony K Mills, Junia V Melo, Deborah L White, Andrew P Grigg, Timothy P Hughes
Most patients with chronic myeloid leukemia (CML) treated with imatinib will relapse if treatment is withdrawn. We conducted a prospective clinical trial of imatinib withdrawal in 40 chronic-phase CML patients who had sustained undetectable minimal residual disease (UMRD) by conventional quantitative polymerase chain reaction (PCR) on imatinib for at least 2 years. Patients stopped imatinib and were monitored frequently for molecular relapse. At 24 months, the actuarial estimate of stable treatment-free remission was 47...
July 25, 2013: Blood
https://www.readbyqxmd.com/read/23436910/a-randomized-controlled-trial-of-acupuncture-self-needling-as-maintenance-therapy-for-cancer-related-fatigue-after-therapist-delivered-acupuncture
#18
RANDOMIZED CONTROLLED TRIAL
A Molassiotis, J Bardy, J Finnegan-John, P Mackereth, W D Ryder, J Filshie, E Ream, D Eaton, A Richardson
BACKGROUND: Maintenance acupuncture is advocated by clinicians after successful clinic-based acupuncture. We aimed to assess the effectiveness of maintenance acupuncture in the management of cancer-related fatigue (CRF); treatment delivered by therapists or self-acupuncture/self-needling was compared with no maintenance treatment. METHODS: Breast cancer patients who participated in a randomized trial of acupuncture for CRF management (reported elsewhere) were re-randomized to receive an additional four acupuncturist-delivered weekly sessions; four self-administered weekly acupuncture sessions (self-needling); or no acupuncture...
June 2013: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/23109700/acupuncture-for-cancer-related-fatigue-in-patients-with-breast-cancer-a-pragmatic-randomized-controlled-trial
#19
RANDOMIZED CONTROLLED TRIAL
Alexander Molassiotis, Joy Bardy, Jennifer Finnegan-John, Peter Mackereth, David W Ryder, Jacqueline Filshie, Emma Ream, Alison Richardson
PURPOSE: We aimed to assess the effectiveness of acupuncture for cancer-related fatigue (CRF) in patients with breast cancer. PATIENTS AND METHODS: We conducted a pragmatic, randomized controlled trial comparing acupuncture with enhanced usual care. Three hundred two outpatients with breast cancer participated. We randomly assigned 75 patients to usual care and 227 patients to acupuncture plus usual care (random assignment of 1:3 respectively) with minimization controlling for baseline general fatigue and maintenance treatment...
December 20, 2012: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/22715121/all-trans-retinoic-acid-idarubicin-and-iv-arsenic-trioxide-as-initial-therapy-in-acute-promyelocytic-leukemia-apml4
#20
Harry J Iland, Ken Bradstock, Shane G Supple, Alberto Catalano, Marnie Collins, Mark Hertzberg, Peter Browett, Andrew Grigg, Frank Firkin, Amanda Hugman, John Reynolds, Juliana Di Iulio, Campbell Tiley, Kerry Taylor, Robin Filshie, Michael Seldon, John Taper, Jeff Szer, John Moore, John Bashford, John F Seymour
The treatment of acute promyelocytic leukemia has improved considerably after recognition of the effectiveness of all-trans-retinoic acid (ATRA), anthracycline-based chemotherapy, and arsenic trioxide (ATO). Here we report the use of all 3 agents in combination in an APML4 phase 2 protocol. For induction, ATO was superimposed on an ATRA and idarubicin backbone, with scheduling designed to exploit antileukemic synergy while minimizing cardiotoxicity and the severity of differentiation syndrome. Consolidation comprised 2 cycles of ATRA and ATO without chemotherapy, followed by 2 years of maintenance with ATRA, oral methotrexate, and 6-mercaptopurine...
August 23, 2012: Blood
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