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Luc Bilodeau

Pascal Thériault-Lauzier, Magdalena Dorfmeister, Darren Mylotte, Ali Andalib, Marco Spaziano, Philipp Blanke, Giuseppe Martucci, Rüdiger Lange, Jonathon Leipsic, Luc Bilodeau, Nicolo Piazza
AIMS: Transcatheter mitral valve replacement (TMVR) is an emerging technology with the potential to treat patients with mitral regurgitation at excessive risk for mitral valve surgery. Geometrical measurements of the mitral valvular complex may have implications for the design of TMVR devices and for patient selection. This study sought to quantify the dynamic geometry of the mitral valvular complex in patients with significant functional mitral regurgitation (FMR) using multi-slice computed tomography (MSCT)...
October 10, 2016: EuroIntervention
Pascal Thériault-Lauzier, Darren Mylotte, Magdalena Dorfmeister, Marco Spaziano, Ali Andalib, Samuel Mamane, Michael Chetrit, Philipp Blanke, Renzo Cecere, Jean Buithieu, Giuseppe Martucci, Didier Tchetche, Thomas Modine, Nicolas van Mieghem, Rüdiger Lange, Stephan Windecker, Luc Bilodeau, Jonathon Leipsic, Nicolo Piazza
AIMS: Transcatheter mitral valve replacement (TMVR) is an emerging technology with the potential to treat patients with severe mitral regurgitation at excessive risk for surgical mitral valve surgery. Multimodality imaging of the mitral valvular complex and surrounding structures will be an important component for patient selection for TMVR. Our aim was to describe and evaluate a systematic multi-slice computed tomography (MSCT) image analysis methodology that provides measurements relevant for transcatheter mitral valve replacement...
October 10, 2016: EuroIntervention
Pierre-Luc St-Charles, Guillaume-Alexandre Bilodeau, Robert Bergevin
Foreground/background segmentation via change detection in video sequences is often used as a stepping stone in high-level analytics and applications. Despite the wide variety of methods that have been proposed for this problem, none has been able to fully address the complex nature of dynamic scenes in real surveillance tasks. In this paper, we present a universal pixel-level segmentation method that relies on spatiotemporal binary features as well as color information to detect changes. This allows camouflaged foreground objects to be detected more easily while most illumination variations are ignored...
January 2015: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
Darren Mylotte, Ali Andalib, Pascal Thériault-Lauzier, Magdalena Dorfmeister, Mina Girgis, Waleed Alharbi, Michael Chetrit, Christos Galatas, Samuel Mamane, Igal Sebag, Jean Buithieu, Luc Bilodeau, Benoit de Varennes, Kevin Lachapelle, Ruediger Lange, Giuseppe Martucci, Renu Virmani, Nicolo Piazza
AIMS: A comprehensive description of transcatheter heart valve (THV) failure has not been performed. We undertook a systematic review to investigate the aetiology, diagnosis, management, and outcomes of THV failure. METHODS AND RESULTS: The systematic review was performed in accordance with the PRISMA guidelines using EMBASE, MEDLINE, and Scopus. Between December 2002 and March 2014, 70 publications reported 87 individual cases of transcatheter aortic valve implantation (TAVI) failure...
June 1, 2015: European Heart Journal
Nicolo Piazza, Giuseppe Martucci, Kevin Lachapelle, Benoit de Varennes, Luc Bilodeau, Jean Buithieu, Darren Mylotte
The CoreValve Evolut R with EnVeo R delivery catheter is a novel transcatheter heart valve (THV) system with enhanced features that have the potential to improve the safety of transcatheter aortic valve implantation (TAVI). The newly designed delivery catheter is 14 Fr-equivalent and thus expands the option of transfemoral TAVI to a greater proportion of patients. Most importantly, the EnVeo R delivery catheter allows the valve to be recaptured and repositioned during deployment, thus minimising the consequences of THV malposition...
March 20, 2014: EuroIntervention
Jimmy Machaalany, Luc Bilodeau, Rainer Hoffmann, Stefan Sack, Horst Sievert, Josef Kautzner, Christoph Hehrlein, Patrick Serruys, Mario Sénéchal, Pamela Douglas, Olivier F Bertrand
OBJECTIVES: PTOLEMY-2 was a prospective multicenter phase I single-arm feasibility trial to evaluate the second-generation permanent percutaneous transvenous mitral annuloplasty (PTMA) device in reducing functional mitral regurgitation (MR). BACKGROUND: Percutaneous MR reduction has been performed through a direct method of clipping and securing the mitral leaflets together or an indirect approach of reducing mitral annular dimension via the coronary sinus. The PTMA device is the only coronary sinus mitral repair device without a static fixation element...
May 2013: American Heart Journal
Konstantinos Marmagkiolis, Emmanouil S Brilakis, Abdul Hakeem, Mehmet Cilingiroglu, Luc Bilodeau
INTRODUCTION: The outcomes of perforation during aortocoronary saphenous vein graft (SVG) percutaneous coronary intervention (PCI) are poorly studied. METHODS: We reviewed all 12 SVG perforations that occurred between November 2005 and November 2011 at two tertiary referral centers. The acute and long-term outcomes of these patients were examined. RESULTS: The perforation was located in the SVG body (n = 6), aortic (n = 3), or distal (n = 3) anastomosis...
March 2013: Journal of Invasive Cardiology
Kostantinos Marmagkiolis, Cindy Grines, Luc Bilodeau
Coronary artery bypass graft surgery remains one of the most widely performed surgical procedures in North America and aortocoronary saphenous vein grafts (SVG) are the most frequently used surgical conduits. SVG disease (SVGD) remains the leading cause of symptomatic coronary artery disease postcoronary artery bypass graft. When optimal medical therapy is ineffective, repeat surgery is associated with higher mortality combined with less favorable clinical and angiographic results, thus percutaneous revascularization on SVG is currently the standard of care for the revascularization of SVGD...
September 1, 2013: Catheterization and Cardiovascular Interventions
Youlan L Gu, Joost D E Haeck, Mathijs Vogelzang, Luc Bilodeau, Mitchell W Krucoff, Jan G P Tijssen, Robbert J de Winter, Felix Zijlstra, Karel T Koch
OBJECTIVE: We investigated whether the Quantitative Blush Evaluator (QuBE) value predicts functional and contrast-enhanced cardiovascular magnetic resonance (CMR) outcomes at 4-6 months after primary percutaneous coronary intervention (PCI) inpatients with ST-segment elevation myocardial infarction (STEMI). BACKGROUND: QuBEis a computer-assisted open source program to quantify myocardial reperfusion.Although a higher QuBE value is associated with improved myocardial reperfusion measures and lower 1-year mortality, the association with intermediate functional parameters after STEMI has not yet been investigated...
February 1, 2011: Catheterization and Cardiovascular Interventions
Joost D E Haeck, Niels J W Verouden, Wichert J Kuijt, Karel T Koch, Jan P Van Straalen, Johan Fischer, Maarten Groenink, Luc Bilodeau, Jan G P Tijssen, Mitchell W Krucoff, Robbert J De Winter
The purpose of the present study was to determine the prognostic value of N-terminal pro-brain natriuretic peptide (NT-pro-BNP), among other serum biomarkers, on cardiac magnetic resonance (CMR) imaging parameters of cardiac function and infarct size in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. We measured NT-pro-BNP, cardiac troponin T, creatinine kinase-MB fraction, high-sensitivity C-reactive protein, and creatinine on the patients' arrival at the catheterization laboratory in 206 patients with ST-segment elevation myocardial infarction...
April 15, 2010: American Journal of Cardiology
Dabit Arzamendi, Luc Bilodeau, Reda Ibrahim, Stephane Noble, Richard Gallo, Philippe Lavoie-L'allier, Gilbert Gosselin, Pierre Deguise, Hung Ly, Jean-François Tanguay, Serge Doucet
AIMS: Mortality of massive pulmonary embolism remains exceedingly high despite thrombolytic therapy. Despite initial encouraging results, rheolytic thrombectomy has not been considered the first choice of treatment in the current European Guidelines for massive pulmonary embolism, even in cases of major contraindication to thrombolysis. Our objective was to assess the efficacy of rheolytic thrombectomy in the specific treatment of massive pulmonary embolism with contraindication to systemic thrombolytic therapy...
January 2010: EuroIntervention
Joost D E Haeck, Youlan L Gu, Mathijs Vogelzang, Luc Bilodeau, Mitchell W Krucoff, Jan G P Tijssen, Robbert J De Winter, Felix Zijlstra, Karel T Koch
OBJECTIVES: The aim of the study was to evaluate whether the "Quantitative Blush Evaluator" (QuBE) score is associated with measures of myocardial reperfusion in patients with ST-segment elevation myocardial infarction (STEMI) treated in two hospitals with 24/7 coronary intervention facilities. BACKGROUND: QuBE is an open source computer program to quantify myocardial perfusion. Although QuBE has shown to be practical and feasible in the patients enrolled in the Thrombus Aspiration during Percutaneous Coronary Intervention in Acute Myocardial Infarction Study (TAPAS), QuBE has not yet been verified on reperfusion outcomes of primary percutaneous coronary intervention (PCI) patients treated in other catheterization laboratories...
April 1, 2010: Catheterization and Cardiovascular Interventions
Stefan Sack, Philipp Kahlert, Luc Bilodeau, Luc A Pièrard, Patrizio Lancellotti, Victor Legrand, Jozef Bartunek, Marc Vanderheyden, Rainer Hoffmann, Patrick Schauerte, Takahiro Shiota, David S Marks, Raimund Erbel, Stephen G Ellis
BACKGROUND: We assessed the safety and feasibility of permanent implantation of a novel coronary sinus mitral repair device (PTMA, Viacor Inc). METHODS AND RESULTS: Symptomatic (New York Heart Association class 2 or 3) patients with primarily functional mitral regurgitation (MR) were included. A diagnostic PTMA procedure was performed in the coronary sinus venous continuity. MR was assessed and the PTMA device adjusted to optimize efficacy. If MR reduction (> or =1 grade) was observed, placement of a PTMA implant was attempted...
August 2009: Circulation. Cardiovascular Interventions
Joost D E Haeck, Karel T Koch, Luc Bilodeau, René J Van der Schaaf, José P S Henriques, Marije M Vis, Jan Baan, Allard C Van der Wal, Jan J Piek, Jan G P Tijssen, Mitchell W Krucoff, Robbert J De Winter
OBJECTIVES: The purpose of this study was to evaluate the effectiveness of combined proximal embolic protection with thrombus aspiration (Proxis Embolic Protection System [St. Jude Medical, St. Paul, Minnesota]) in ST-segment elevation myocardial infarction patients. BACKGROUND: Embolization during primary percutaneous coronary intervention (PCI) may result in microvascular obstruction, reduced myocardial perfusion, and impaired prognosis. METHODS: Two hundred eight-four patients were randomized to primary PCI with the Proxis system versus primary PCI alone after angiography...
October 2009: JACC. Cardiovascular Interventions
Stephen Fort, Ran Kornowski, Sigmund Silber, Basil S Lewis, Luc Bilodeau, Yaron Almagor, Eric van Remortel, Marie-Claude Morice, Antonio Colombo
OBJECTIVES: We evaluated the long-term clinical and angiographic results of 'fused-gold' (NIRFlex Royal) and 'bare' (NIRFlex) stainless steel stents in patients undergoing percutaneous coronary intervention (PCI). BACKGROUND: Recent studies have shown high clinical and angiographic restenosis rates following the intracoronary implantation of 'gold-coated' stainless steel stents. The new 'fused-gold' stent, with improved surface characteristics and flexibility, was developed to improve procedural and long-term results, while maintaining enhanced radiopacity...
August 2007: EuroIntervention
Stéphanie Lacroix, Annie Ferland, Phiilippe Gilbert, Michel Lemieux, Luc Bilodeau, P Poirier
An unusual case of a toothpick perforating the distal one-third of the duodenum, penetrating the inferior vena cava and thereafter migrating to the right atrium with extensive pericardial fibrosis is reported. A 60-year-old man was admitted to the emergency department because of epigastric pain, which had progressively worsened. After partial recovery, he was discharged. However, after four episodes of different gastrointestinal bacteria septicemias of unknown origin over a period of five months, the patient was transferred to Laval Hospital (Laval, Quebec) for clinical investigation...
July 2009: Canadian Journal of Cardiology
Duncan J Stewart, Michael J B Kutryk, David Fitchett, Michael Freeman, Nancy Camack, Yinghua Su, Anthony Della Siega, Luc Bilodeau, Jeffrey R Burton, Guy Proulx, Sam Radhakrishnan
Despite the promise of proangiogenic gene therapy most clinical trials have failed to show benefit for the primary end point analysis. The NOGA angiogenesis Revascularization Therapy: assessment by RadioNuclide imaging (NORTHERN) trial was a double-blind, placebo-controlled study of intramyocardial vascular endothelial growth factor (VEGF165) gene therapy versus placebo, involving seven sites across Canada, designed to overcome major limitations of previous proangiogenic gene therapy trials. A total of 93 patients with refractory Canadian Cardiovascular Society (CCS) class 3 or 4 anginal symptoms were randomized to receive 2,000 microg of VEGF plasmid DNA or placebo (buffered saline) delivered via the endocardial route using an electroanatomical NOGA guidance catheter...
June 2009: Molecular Therapy: the Journal of the American Society of Gene Therapy
Piotr Waciński, Luc Bilodeau, Reda Ibrahim
Acute ventricular septal rupture - ventricular septal defect (VSD) following acute myocardial infarction remains a critical condition. We present an 80 year-old patient with an acute VSD following an acute inferior myocardial infarction. Percutaneous VSD closure with an Amplatzer ventricular septal occluder (AVSO) was performed successfully, two days after initial admission. In-hospital follow-up was uneventful. We speculate that percutaneous VSD closure with an AVSO can be an alternative to surgical correction for these patients...
2007: Cardiology Journal
Eric Marsault, Hamid R Hoveyda, René Gagnon, Mark L Peterson, Martin Vézina, Carl Saint-Louis, Annick Landry, Jean-François Pinault, Luc Ouellet, Sophie Beauchemin, Sylvie Beaubien, Axel Mathieu, Kamel Benakli, Zhigang Wang, Martin Brassard, David Lonergan, François Bilodeau, Mahesh Ramaseshan, Nadia Fortin, Ruoxi Lan, Shigui Li, Fabrice Galaud, Véronique Plourde, Manon Champagne, Annie Doucet, Patrick Bhérer, Maude Gauthier, Gilles Olsen, Gérald Villeneuve, Shridhar Bhat, Laurence Foucher, Daniel Fortin, Xiaowen Peng, Sylvain Bernard, Alexandre Drouin, Robert Déziel, Gilles Berthiaume, Yves L Dory, Graeme L Fraser, Pierre Deslongchamps
A new method for solid phase parallel synthesis of chemically and conformationally diverse macrocyclic peptidomimetics is reported. A key feature of the method is access to broad chemical and conformational diversity. Synthesis and mechanistic studies on the macrocyclization step are reported.
August 15, 2008: Bioorganic & Medicinal Chemistry Letters
Stéphane Noble, Luc Bilodeau
Balloon refractory calcific coronary plaques remain a technical challenge. Stent underexpansion is known as a major cause of restenosis and thrombosis. We report a case of in-stent restenosis 5 months after stent suboptimal implantation in a noncompliant calcific atherosclerotic plaque which could not be disrupted by repeated prolonged high-pressure balloon inflations. High-energy excimer laser use altered underlying lesion morphology, allowing full stent apposition. Advances in equipment and technique have allowed more frequent use of high energy excimer laser technology during percutaneous coronary angioplasty with very low rates of complications...
May 1, 2008: Catheterization and Cardiovascular Interventions
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