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AKI prevention

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https://www.readbyqxmd.com/read/27888759/prevention-of-statins-against-aki-and-mortality-following-cardiac-surgery-do-we-know-enough-a-trial-sequential-analysis
#1
Hong Weng, Sheng Li, Xian-Tao Zeng
No abstract text is available yet for this article.
November 12, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27881606/mitochondria-protection-after-acute-ischemia-prevents-prolonged-upregulation-of-il-1%C3%AE-and-il-18-and-arrests-ckd
#2
Hazel H Szeto, Shaoyi Liu, Yi Soong, Surya V Seshan, Leona Cohen-Gould, Viacheslav Manichev, Leonard C Feldman, Torgny Gustafsson
The innate immune system has been implicated in both AKI and CKD. Damaged mitochondria release danger molecules, such as reactive oxygen species, DNA, and cardiolipin, which can cause NLRP3 inflammasome activation and upregulation of IL-18 and IL-1β It is not known if mitochondrial damage persists long after ischemia to sustain chronic inflammasome activation. We conducted a 9-month study in Sprague-Dawley rats after 45 minutes of bilateral renal ischemia. We detected glomerular and peritubular capillary rarefaction, macrophage infiltration, and fibrosis at 1 month...
November 23, 2016: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/27879188/the-sustainable-kidney-care-foundation-s-contribution-to-the-improvement-of-aki-management-in-developing-countries-using-peritoneal-dialysis
#3
Mary Carter, Nathan W Levin, Calvin S Carter, John Callegari
Professional organizations, such as kidney foundations, have been active for over half a century in the field of nephrology, serving as the basic institutions for advocacy, disease education, prevention, and treatment. These organizations have focused efforts in four areas: supporting the training of clinical specialists, raising awareness about kidney disease, improving patient outcomes, and organizing continuing medical education. These activities, while essential for the success of nephrology organizations, do not usually initiate renal service programs in the neediest of places...
2016: Clinical Nephrology
https://www.readbyqxmd.com/read/27876077/post-traumatic-acute-kidney-injury-a-cross-sectional-study-of-trauma-patients
#4
Wei-Hung Lai, Cheng-Shyuan Rau, Shao-Chun Wu, Yi-Chun Chen, Pao-Jen Kuo, Shiun-Yuan Hsu, Ching-Hua Hsieh, Hsiao-Yun Hsieh
BACKGROUND: The causes of post-traumatic acute kidney injury (AKI) are multifactorial, and shock associated with major trauma has been proposed to result in inadequate renal perfusion and subsequent AKI in trauma patients. This study aimed to investigate the true incidence and clinical presentation of post-traumatic AKI in hospitalized adult patients and its association with shock at a Level I trauma center. METHODS: Detailed data of 78 trauma patients with AKI and 14,504 patients without AKI between January 1, 2009 and December 31, 2014 were retrieved from the Trauma Registry System...
November 22, 2016: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/27853882/the-protective-effect-of-human-atrial-natriuretic-peptide-on-renal-damage-during-cardiac-surgery
#5
Takahiro Moriyama, Shintaro Hagihara, Toko Shiramomo, Misaki Nagaoka, Shohei Iwakawa, Yuichi Kanmura
PURPOSE: Acute kidney injury (AKI) is one of the critical complications after cardiac surgery. In the kidney, angiotensin II (Ang II) is formed by independent mechanisms, and activity of the intrarenal renin-angiotensin-aldosterone (RAAS) system contributes to the progression of kidney damage. Although atrial natriuretic peptide (ANP) exerts protective effects against renal injury by inhibiting the RAAS, the mechanisms of this effect have not been completely clarified. We investigated how human ANP (hANP) could prevent renal damage induced by cardiopulmonary bypass...
November 16, 2016: Journal of Anesthesia
https://www.readbyqxmd.com/read/27848094/aminoglycoside-induced-nephrotoxicity-in-children
#6
REVIEW
Stephen J McWilliam, Daniel J Antoine, Rosalind L Smyth, Munir Pirmohamed
Aminoglycoside antibiotics, in particular gentamicin and tobramycin, are still commonly used in paediatric clinical practice. These drugs cause nephrotoxicity, which particularly affects the proximal tubule epithelial cells due to selective endocytosis and accumulation of aminoglycosides via the multi-ligand receptor megalin. Recent epidemiological studies, using more widely accepted definitions of acute kidney injury (AKI), have suggested that AKI may occur in between 20 and 33 % of children exposed to aminoglycosides...
November 15, 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/27832187/risk-factors-for-acute-kidney-injury-after-congenital-cardiac-surgery-in-infants-and-children-a-retrospective-observational-study
#7
Sun-Kyung Park, Min Hur, Eunhee Kim, Won Ho Kim, Jung Bo Park, Youngwon Kim, Ji-Hyuk Yang, Tae-Gook Jun, Chung Su Kim
Acute kidney injury (AKI) after pediatric cardiac surgery is associated with high morbidity and mortality. Modifiable risk factors for postoperative AKI including perioperative anesthesia-related parameters were assessed. The authors conducted a single-center, retrospective cohort study of 220 patients (aged 10 days to 19 years) who underwent congenital cardiac surgery between January and December 2012. The incidence of AKI within 7 days postoperatively was determined using the Kidney Disease: Improving Global Outcomes (KDIGO) criteria...
2016: PloS One
https://www.readbyqxmd.com/read/27831955/ce-preventing-contrast-induced-acute-kidney-injury
#8
Yvonne Gallegos, Asma Ali Taha, Dana N Rutledge
: Diagnostic radiographic imaging scans using intravascular iodinated contrast media can lead to various complications. The most salient of these is contrast-induced acute kidney injury (CI-AKI) or contrast-induced nephropathy, a potentially costly and serious patient safety concern. Prevention strategies are the cornerstone of evidence-based clinical management for patients receiving contrast agents. These include preprocedure screening, stratification of patients based on risk factors, and protective interventions, the most important of which is hydration both before and after the radiographic imaging scan...
December 2016: American Journal of Nursing
https://www.readbyqxmd.com/read/27829991/p53-inhibitor-pifithrin-%C3%AE-prevents-the-renal-tubular-epithelial-cells-against-injury
#9
Yun-Lin Shen, Lei Sun, Yu-Jie Hu, Hua-Jie Liu, Xin-Yu Kuang, Xiao-Ling Niu, Wen-Yan Huang
The injury and repair of renal tubular epithelial cells play an important role in the pathological process of acute kidney injury (AKI). This study aimed to clarify the role of cell cycle change in renal tubular epithelial cell injury and repair in vivo and in vitro. Sprague-Dawley rats received bilateral renal pedicle clamping for 45 min (ischemia) followed by reperfusion. Pifithrin-α, a p53 inhibitor, was administered at 24 h before renal ischemia and 3 and 14 days after reperfusion. Results showed the tubular epithelial cells in M phase increased significantly at 2 h to 72 h after ischemia/reperfusion (I/R), while pifithrin-α decreased them...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27821094/outcomes-risk-factors-and-health-burden-of-contrast-induced-acute-kidney-injury-an-observational-study-of-one-million-hospitalizations-with-image-guided-cardiovascular-procedures
#10
Pierre Aubry, Georges Brillet, Laura Catella, Aurélie Schmidt, Stève Bénard
BACKGROUND: Despite the use of low-osmolar contrast media that have significantly reduced the occurrence of severe adverse reactions, contrast-induced (CI) acute kidney injury (AKI) remains the third cause of AKI in hospitals. We sought to estimate the frequency of CI-AKI among hospitalized patients undergoing image-guided cardiovascular procedures, to quantify the effect of risk factors on the development of this complication and to assess relative organizational and economic burden in healthcare...
November 8, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27811558/renal-protection-in-the-21st-century
#11
Melanie Meersch, Alexander Zarbock
PURPOSE OF REVIEW: Among critically ill patients, acute kidney injury (AKI) is still a common and serious complication with a tremendous impact on short-term and long-term outcomes. The objective of this review is to discuss strategies for renal protection and prevention of AKI in ICU patients. RECENT FINDINGS: It is fundamental to identify patients at risk for AKI as soon as possible and as accurately as possible. In order to achieve these goals, translational approaches implementing new biomarkers have shown promising results...
December 2016: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/27803367/management-of-post-operative-acute-kidney-injury
#12
S Bell, V C Ross, K A Zealley, F Millar, C Isles
Post-operative acute kidney injury (AKI) is a common complication of surgery with significant short- and long-term adverse consequences. The adoption of diagnostic criteria for AKI (RIFLE, AKIN and KDIGO) has facilitated comparison of data reported by different centres, confirming that even mild AKI is associated with excess mortality. It remains unclear whether this is caused by the kidney injury itself or whether AKI is simply a marker of underlying disease severity. There is no trial evidence to support the use of any specific therapeutic intervention in post-operative AKI...
October 18, 2016: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/27801506/impact-of-acute-kidney-injury-following-liver-transplantation-on-long-term-outcomes
#13
Emilie Trinh, Ahsan Alam, Jean Tchervenkov, Marcelo Cantarovich
BACKGROUND: The incidence of acute kidney injury (AKI) after liver transplantation (LTx) ranges from 17% to 94%. AKI is associated with prolonged hospitalization and increased early mortality. In our cohort study, we examined the impact of AKI on long-term patient survival and on the incidence of stage 4-5 chronic kidney disease (CKD). METHODS: We studied 491 LTx recipients at a single center between 1990 and 2012. We identified 278 pts (56.6%) with AKI defined as either an increase in serum creatinine (SCr) ≥26...
November 1, 2016: Clinical Transplantation
https://www.readbyqxmd.com/read/27800691/xuezhikang-ameliorates-contrast-media-induced-nephropathy-in-rats-via-suppression-of-oxidative-stress-inflammatory-responses-and-apoptosis
#14
Shichun Chu, Liuhua Hu, Xiaolei Wang, Shiqun Sun, Tuo Zhang, Zhe Sun, Linghong Shen, Shuxuan Jin, Ben He
BACKGROUND: The aim of this study was to assess the preventive effect of xuezhikang (XZK) to replace atorvastatin on the contrast media-induced acute kidney injury (CI-AKI). METHODS: The male Sprague-Dawley rats were divided into five groups: group 1 (sham), injected with normal saline; group 2 (XZK), treated with XZK; group 3 contrast media (CM), injected with CM; group 4 (CM + ATO), injected with CM + pretreatment with atorvastatin; group 5 (CM + XZK), injected with CM + pretreatment with XZK...
November 1, 2016: Renal Failure
https://www.readbyqxmd.com/read/27798731/impact-of-combined-lipid-lowering-and-blood-pressure-control-on-coronary-plaque-myocardial-ischemia-treated-by-percutaneous-coronary-intervention-and-plaque-regression-by-lipid-lowering-and-blood-pressure-controlling-assessed-by-intravascular-ultrasonography
#15
Masa-Aki Kawashiri, Kenji Sakata, Kenshi Hayashi, Tadatsugu Gamou, Honin Kanaya, Kenji Miwa, Kosei Ueda, Toshinori Higashikata, Sumio Mizuno, Ichiro Michishita, Masanobu Namura, Yutaka Nitta, Shoji Katsuda, Kazuyasu Okeie, Hiroaki Hirase, Hayato Tada, Katsuharu Uchiyama, Tetsuo Konno, Hidekazu Ino, Keisuke Nagase, Masakazu Yamagishi
The aim of the study was to elucidate the aggressive reduction of both low-density lipoprotein cholesterol (LDL-C) and blood pressure (BP) reduced coronary atherosclerotic plaque volume compared with a standard treatment of LDL-C and BP in Japanese patients with coronary artery disease (CAD). This study is a prospective, randomized, and open-labelled with a blind-endpoint evaluation study. A total of 97 patients (81 men, mean age 62.0 ± 9.6) with CAD undergoing intravascular ultrasonography (IVUS)-guided percutaneous coronary intervention (PCI) were randomized, and 68 patients had IVUS examinations at baseline and at 18-24 months follow-up...
October 31, 2016: Heart and Vessels
https://www.readbyqxmd.com/read/27783968/prevention-of-post-procedural-acute-kidney-injury-in-the-catheterization-laboratory-in-a-real-world-population
#16
Ehud Chorin, Eyal Ben-Assa, Maayan Konigstein, May-Tal Rofe, Aviram Hochstadt, Naama Galli, Michael Schnapper, Yaron Arbel, Ilan Rabey, Jeremy Ben Shoshan, Amir Halkin, Itzhak Herz, Ariel Finkelstein, Samuel Bazan, Gad Keren, Shmuel Banai
BACKGROUND: Radiologists and cardiologists have a remarkably different approach to the clinical importance and to the need for prophylactic treatment of contrast-induced acute kidney injury (CI-AKI). OBJECTIVES: To evaluate the efficacy of forced diuresis with matched controlled hydration (FMH) in a real-world, high risk population. METHODS: This is an investigator-driven, single-center, retrospective analysis of prospectively collected data...
January 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/27781957/valsartan-protects-against-contrast-induced-acute-kidney-injury-in-rats-by-inhibiting-endoplasmic-reticulum-stress-induced-apoptosis
#17
Yan Sun, Ping-An Peng, Yue Ma, Xiaoli Liu, Yi Yu, Shuo Jia, Xiaohan Xu, Sijing Wu, Yujie Zhou
Contrast-induced acute kidney injury (CI-AKI) is a serious complication of the administration of iodinated contrast media (CM) for diagnostic and interventional cardiovascular procedures and is associated with substantial morbidity and mortality. While the preventative measures can mitigate the risk of CI-AKI, there remains a need for novel and effective therapeutic approaches. The pathogenesis of CI-AKI is complex and not completely understood. CM-induced renal tubular cell apoptosis caused by the activation of endoplasmic reticulum (ER) stress is involved in CI-AKI...
October 25, 2016: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/27779776/a-phase-i-study-to-determine-the-pharmacokinetic-profile-safety-and-tolerability-of-sildenafil-revatio-%C3%A2-in-cardiac-surgery-the-revaki-1-study
#18
Arne Ring, Tom Morris, Marcin Wozniak, Nikol Sullo, William Dott, Veerle Verheyden, Tracy Kumar, Nigel Brunskill, Rakesh Vaja, Gavin J Murphy
AIMS: Acute kidney injury (AKI) is a common and severe complication of cardiac surgery. There is no effective prevention or treatment. Sildenafil citrate (Revatio(®) , Pfizer Inc.), a phosphodiesterase type 5 inhibitor, prevents post cardiac surgery AKI in pre-clinical studies, however its use is contraindicated in patients with symptomatic cardiovascular disease. The aim of this study is to assess the safety and pharmacokinetics of intravenous sildenafil in cardiac surgery patients...
October 25, 2016: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27778375/mycophenolate-mofetil-improves-renal-hemodynamics-microvascular-oxygenation-and-inflammation-in-a-rat-model-of-supra-renal-aortic-clamping-mediated-renal-ischemia-reperfusion-injury
#19
Bulent Ergin, Michal Heger, Asli Kandil, Cihan Demirci-Tansel, Can Ince
Ischemia/reperfusion (I/R) is one of the main causes of acute kidney injury (AKI), which is characterized by sterile inflammation and oxidative stress. Immune cell activation can provoke overproduction of inflammatory mediators and reactive oxygen species (ROS), leading to perturbation of the microcirculation and tissue oxygenation associated with local and remote tissue injury. This study investigated whether the clinically employed immunosuppressant mycophenolate mofetil (MMF) was able to reduce I/R-induced renal oxygenation defects and oxidative stress by preventing sterile inflammation...
October 25, 2016: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/27775043/hdl-cholesterol-level-is-associated-with-contrast-induced-acute-kidney-injury-in-chronic-kidney-disease-patients-undergoing-pci
#20
Hoon Suk Park, Chan Joon Kim, Byung-Hee Hwang, Tae-Hoon Kim, Yoon Seok Koh, Hun-Jun Park, Sung-Ho Her, Sung Won Jang, Chul-Soo Park, Jong Min Lee, Hee-Yeol Kim, Doo Soo Jeon, Pum-Joon Kim, Ki-Dong Yoo, Kiyuk Chang, Dong Chan Jin, Ki-Bae Seung
Chronic kidney disease (CKD) is a significant risk factor for contrast induced acute kidney injury (CI-AKI) after percutaneous coronary intervention (PCI). This study included 1592 CKD patients extracted from a prospective multicenter, all comer-based registry of patients undergoing PCI. In multivariate logistic analysis for CI-AKI development, a significant linear trend was observed between the quartiles of HDL-C (quartile 1 vs. 2: odds ratio [OR], 0.716; 95% confidence interval [CI], 0.421-1.219; quartile 1 vs...
October 24, 2016: Scientific Reports
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