keyword
MENU ▼
Read by QxMD icon Read
search

AKI prevention

keyword
https://www.readbyqxmd.com/read/28548696/the-roles-of-continuous-renal-replacement-therapy-in-septic-acute-kidney-injury
#1
Takuya Ueno
Despite hundreds of clinical and basic studies that have led to a better mechanistic understanding of sepsis, the number of cases with sepsis in the United States is still rising. Sepsis is a common cause of acute kidney injury (AKI) and may explain long-term complications and mortality. In the current article, a new therapeutic concept using continuous renal replacement therapy to prevent and manage long-term sequelae in septic AKI is described.
May 26, 2017: Artificial Organs
https://www.readbyqxmd.com/read/28545621/risk-prediction-models-for-contrast-induced-acute-kidney-injury-accompanying-cardiac-catheterization-systematic-review-and-meta-analysis
#2
REVIEW
David W Allen, Bryan Ma, Kelvin C Leung, Michelle M Graham, Neesh Pannu, Mouhieddin Traboulsi, David Goodhart, Merril L Knudtson, Matthew T James
BACKGROUND: Identification of patients at risk of contrast-induced acute kidney injury (CI-AKI) is valuable for targeted prevention strategies accompanying cardiac catheterization. METHODS: We searched MedLine and EMBASE for articles that developed or validated a clinical prediction model for CI-AKI or dialysis after angiography or percutaneous coronary intervention. Random effects meta-analysis was used to pool c-statistics of models. Heterogeneity was explored using stratified analyses and meta-regression...
June 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28545277/-effect-of-the-ischemic-post-conditioning-on-the-prevention-of-the-cardio-renal-damage-in-patients-with-acute-st-segment-elevation-myocardial-infarction-after-primary-percutaneous-coronary-intervention
#3
Y Y Wang, T Li, Y W Liu, B J Liu, X M Hu, Y Wang, W Q Gao, P Wu, L Huang, X Li, W J Peng, M Ning
Objective: To evaluate the effect of the ischemic post-conditioning (IPC) on the prevention of the cardio-renal damage in patients with acute ST-segment elevation myocardial infarction (STEMI) after primary percutaneous coronary intervention (PPCI). Methods: A total of 251 consecutive STEMI patients underwent PPCI in the heart center of Tianjin Third Central Hospital from January 2012 to June 2014 were enrolled in this prospective, randomized, control, single-blinded, clinical registry study. Patients were randomly divided into IPC group (123 cases) and control group (128 cases) with random number table...
April 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/28544332/fibroblast-growth-factor-2-protects-against-renal-ischaemia-reperfusion-injury-by-attenuating-mitochondrial-damage-and-proinflammatory-signalling
#4
Xiao-Hua Tan, Xiao-Meng Zheng, Li-Xia Yu, Jian He, Hong-Mei Zhu, Xiu-Ping Ge, Xiao-Li Ren, Fa-Qing Ye, Saverio Bellusci, Jian Xiao, Xiao-Kun Li, Jin-San Zhang
Ischaemia-reperfusion injury (I/RI) is a common cause of acute kidney injury (AKI). The molecular basis underlying I/RI-induced renal pathogenesis and measures to prevent or reverse this pathologic process remains to be resolved. Basic fibroblast growth factor (FGF2) is reported to have protective roles of myocardial infarction as well as in several other I/R related disorders. Herein we present evidence that FGF2 exhibits robust protective effect against renal histological and functional damages in a rat I/RI model...
May 24, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28540198/contrast-induced-acute-kidney-injury-a-review-of-practical-points
#5
REVIEW
Sercin Ozkok, Abdullah Ozkok
Contrast-induced acute kidney injury (CI-AKI) is one of the most common causes of AKI in clinical practice. CI-AKI has been found to be strongly associated with morbidity and mortality of the patients. Furthermore, CI-AKI may not be always reversible and it may be associated with the development of chronic kidney disease. Pathophysiology of CI-AKI is not exactly understood and there is no consensus on the preventive strategies. CI-AKI is an active research area thus clinicians should be updated periodically about this topic...
May 6, 2017: World Journal of Nephrology
https://www.readbyqxmd.com/read/28539382/il233-a-novel-il-2-and-il-33-hybrid-cytokine-ameliorates-renal-injury
#6
Marta E Stremska, Sheethal Jose, Vikram Sabapathy, Liping Huang, Amandeep Bajwa, Gilbert R Kinsey, Poonam R Sharma, Saleh Mohammad, Diane L Rosin, Mark D Okusa, Rahul Sharma
CD4(+)Foxp3(+) regulatory T cells (Tregs) protect the kidney during AKI. We previously found that IL-2, which is critical for Treg homeostasis, upregulates the IL-33 receptor (ST2) on CD4(+) T cells, thus we hypothesized that IL-2 and IL-33 cooperate to enhance Treg function. We found that a major subset of Tregs in mice express ST2, and coinjection of IL-2 and IL-33 increased the number of Tregs in lymphoid organs and protected mice from ischemia-reperfusion injury (IRI) more efficiently than either cytokine alone...
May 24, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28529921/mediterranean-lifestyle-and-cardiovascular-disease-prevention
#7
Ekavi N Georgousopoulou, Duane D Mellor, Nenad Naumovski, Evangelos Polychronopoulos, Stefanos Tyrovolas, Suzanne Piscopo, Giuseppe Valacchi, Foteini Anastasiou, Akis Zeimbekis, Vassiliki Bountziouka, Efthimios Gotsis, George Metallinos, Dimitra Tyrovola, Alexandra Foscolou, Josep-Antoni Tur, Antonia-Leda Matalas, Christos Lionis, Labros Sidossis, Demosthenes Panagiotakos
BACKGROUND: Adherence to a Mediterranean dietary pattern is a well-established protective factor against cardiovascular disease (CVD). However, diet quality is only one aspect of the overall healthy lifestyle adopted by Mediterranean populations. The latter has never been evaluated as a multi-factorial composite lifestyle. Thus, the aim of the present study was to provide a broader picture of the Mediterranean lifestyle and its effects on CVD risk, among elderly individuals. METHODS: During 2005-2015, 2,749 older (aged 65-100 years) from 21 Mediterranean islands (MEDIS) and the rural Mani region (Peloponnesus) of Greece were voluntarily enrolled onto the study...
April 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/28525506/haptoglobin-administration-in-cardiovascular-surgery-patients-its-association-with-the-risk-of-postoperative-acute-kidney-injury
#8
Kenta Kubota, Moritoki Egi, Satoshi Mizobuchi
BACKGROUND: Acute kidney injury (AKI) often occurs after cardiac surgery. During cardiac surgery, plasma free hemoglobin (fHb) would increase due to hemolysis. Since plasma fHb is thought to be nephrotoxic, haptoglobin, which is an fHb scavenger, may have the potential to prevent postoperative AKI (pAKI). However, there have been few studies in which the association of intraoperative administration of haptoglobin with the incidence of AKI after cardiac surgery was assessed. METHODS: This study was a retrospective observational study to assess the independent association of intraoperative administration of haptoglobin with the incidence pAKI in cardiac surgery patients...
June 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28525419/safe-hydration-volume-to-prevent-contrast-induced-acute-kidney-injury-and-worsening-heart-failure-in-patients-with-heart-failure-and-preserved-ejection-fraction-following-cardiac-catheterization
#9
Wei-Jie Bei, Kun Wang, Hua-Long Li, Kai-Yang Lin, Xiao-Sheng Guo, Shi-Qun Chen, Yong Liu, Shi-Xin Yi, De-Mou Luo, Ji-Yan Chen, Fesc, Ning Tan
Few studies have investigated the efficacy and safety of hydration to prevent contrast-induced acute kidney injury (CI-AKI) and worsening heart failure (WHF) following cardiac catheterization in heart failure and preserved ejection fraction (HFpEF; HF and EF ≥50%) patients. We recruited 1206 patients with HFpEF undergoing cardiac catheterization with peri-procedural hydration volume/weight ratios (HV/W) data and investigated the relationship between hydration volumes and risk of CI-AKI and WHF. Incidence of CI-AKI was not significantly reduced in individuals with higher HV/W (quartile [Q] 1, Q2, Q3, and Q4: 9...
April 27, 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/28515179/arginase-2-mediates-renal-ischemia-reperfusion-injury
#10
Wesley M Raup-Konsavage, Ting Gao, Timothy K Cooper, Sidney M Morris, W Brian Reeves, Alaa S Awad
Novel therapeutic interventions for preventing or attenuating kidney injury following ischemia/reperfusion injury (IRI) remain a focus of significant interest. Currently, there are no definitive therapeutic or preventive approaches available for ischemic acute kidney injury (AKI). Our objective is to determine (a) whether renal arginase activity or expression is increased in renal IRI and (b) whether arginase plays a role in development of renal IRI. The impact of arginase activity and expression on renal damage was evaluated in male C57BL/6J (WT) and arginase-2 deficient (Arg2(-/-) ) mice subjected to bilateral renal ischemia for 28min followed by reperfusion for 24h...
May 17, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28502971/targeting-the-keap1-nrf2-system-to-prevent-kidney-disease-progression
#11
Masahiro Nezu, Norio Suzuki, Masayuki Yamamoto
BACKGROUND: Nuclear factor erythroid 2-related factor 2 (NRF2) is a critical transcription factor for the antioxidative stress response and it activates a variety of cytoprotective genes related to redox and detoxification. NRF2 activity is regulated by the oxidative-stress sensor molecule Kelch-like ECH-associated protein 1 (KEAP1) that induces proteasomal degradation of NRF2 through ubiquitinating NRF2 under unstressed conditions. Because oxidative stress is a major pathogenic and aggravating factor for kidney diseases, the KEAP1-NRF2 system has been proposed to be a therapeutic target for renal protection...
May 13, 2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/28497278/il-35-pretreatment-alleviates-lipopolysaccharide-induced-acute-kidney-injury-in-mice-by-inhibiting-nf-%C3%AE%C2%BAb-activation
#12
Linkun Hu, Cheng Chen, Jun Zhang, Kerong Wu, Xuefeng Zhang, Haiyan Liu, Jianquan Hou
Septic acute kidney injury (AKI) is a public health problem with high mortality. Suppression of over-active inflammation is considered as a promising strategy for septic AKI. In this study, we evaluated the prophylactic effect of interleukin (IL)-35, the unique immune-suppressive member of IL-12 cytokine family, on lipopolysaccharide (LPS)-induced AKI in mice, and found that compared with control mice given empty vector, mice pretreated with plasmid encoding IL-35 (pIL-35) significantly improved renal function indicated by reduced blood urea nitrogen (BUN) and serum creatinine (SCr), and obviously alleviated renal pathological changes...
May 11, 2017: Inflammation
https://www.readbyqxmd.com/read/28495528/hepatic-ischemia-reperfusion-injury-disrupts-the-homeostasis-of-kidney-primary-cilia-via-oxidative-stress
#13
Sang Jun Han, Hee-Seong Jang, Sung Young Seu, Hee-Jung Cho, Yoon Jin Hwang, Jee In Kim, Kwon Moo Park
Acute kidney injury (AKI) is a major complication of hepatic surgeries. The primary cilium protrudes to the lumen of kidney tubules and plays an important role in renal functions. Disruption of primary cilia homeostasis is highly associated with human diseases including AKI. Here, we investigated whether transient hepatic ischemia induces length change and deciliation of kidney primary cilia, and if so, whether reactive oxygen species (ROS)/oxidative stress regulates those. HIR induced damages to the liver and kidney with increases in ROS/oxidative stress...
May 8, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28490444/inhibiting-glucosylceramide-synthase-exacerbates-cisplatin-induced-acute-kidney-injury
#14
Tess V Dupre, Mark A Doll, Parag P Shah, Cierra N Sharp, Deanna Siow, Judit Megyesi, James Shayman, Alicja Bielwska, Jacek Bielawski, Levi J Beverly, Maria Hernandez-Corbacho, Christopher J Clarke, Ashley J Snider, Rick G Schnellmann, Lina M Obeid, Yusuf A Hannun, Leah J Siskind
Acute kidney injury (AKI), resulting from chemotherapeutic agents such as cisplatin, remains an obstacle in the treatment of cancer. Cisplatin-induced AKI involves apoptotic and necrotic cell death, pathways regulated by sphingolipids such as ceramide and glucosylceramide. Results from this study indicate that C57BL/6J mice treated with cisplatin had increased ceramide and hexosylceramide levels in the renal cortex 72 h following cisplatin treatment. Pre-treatment of mice with inhibitors of acid sphingomyelinase and de novo ceramide synthesis (amitriptyline and myriocin, respectively) prevented accumulation of ceramides and hexosylceramide in the renal cortex and protected from cisplatin-induced AKI...
May 10, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28487950/flow-control-effect-of-necrostatin-1-on-cell-death-of-the-nrk-52e-renal-tubular-epithelial-cell-line
#15
Jialun Luo, Yiming Tao, Xinling Liang, Yuanhan Chen, Li Zhang, Fen Jiang, Shuangxin Liu, Zhiming Ye, Zhilian Li, Wei Shi
Apoptosis and necroptosis occur in renal tubular epithelial cell (RTEC) death in acute kidney injury (AKI), and may be regulated by several methods. The present study identified a protective effect of necrostatin‑1 (Nec‑1) on RTECs via a flow-control-like effect. The results established a hypoxic‑ischemic injury model of rat NRK‑52E RTECs using tumour necrosis factor‑α followed by ATP depletion with antimycin A and the pan-caspase pathway blocker, benzyloxycarbonyl-Val-Ala-Asp-fluoro-methylketone...
May 9, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28487772/incidence-and-risk-factors-for-early-acute-kidney-injury-in-nonsurgical-patients-a-cohort-study
#16
Javier Enrique Cely, Elkin José Mendoza, Carlos Roberto Olivares, Oscar Julián Sepúlveda, Juan Sebastián Acosta, Rafael Andrés Barón, Juan José Diaztagle
Introduction. Detecting acute kidney injury (AKI) in the first days of hospitalization could prevent potentially fatal complications. However, epidemiological data are scarce, especially on nonsurgical patients. Objectives. To determine the incidence and risk factors associated with AKI within five days of hospitalization (EAKI). Methods. Prospective cohort of patients hospitalized in the Internal Medicine Department. Results. A total of 16% of 400 patients developed EAKI. The associated risk factors were prehospital treatment with nephrotoxic drugs (2...
2017: International Journal of Nephrology
https://www.readbyqxmd.com/read/28487437/hypoglycemic-effect-of-combined-ghrelin-and-glucagon-receptor-blockade
#17
Bharath K Mani, Aki Uchida, Young Lee, Sherri Osborne-Lawrence, Maureen J Charron, Roger H Unger, Eric D Berglund, Jeffrey M Zigman
Glucagon receptor (GcgR) blockade has been proposed as an alternative to insulin monotherapy for treating Type 1 diabetes mellitus since deletion or inhibition of GcgRs corrects hyperglycemia in diabetic models. The factors regulating glycemia in a setting devoid of insulin and glucagon function remain unclear, but may include the hormone ghrelin. Not only is ghrelin release controlled by glucose, but also ghrelin has many actions that can raise or reduce falls in blood glucose. Here, we tested the hypothesis that ghrelin rises to minimize hypoglycemia in the absence of glucagon function...
May 9, 2017: Diabetes
https://www.readbyqxmd.com/read/28486233/renal-autotransplantation-with-autologous-saphenous-vein-graft-in-a-patient-with-takayasu-arteritis-and-existing-renal-artery-stent-in-her-solitary-kidney
#18
Hakan Bahadir Haberal, Senol Tonyali, Bora Peynircioğlu, Mustafa Arici, Metin Demircin, Fazıl Tuncay Aki
Takayasu arteritis is a disease that results in the granulomatous inflammation of large vessel walls. Takayasu arteritis is generally observed in young females during the second or third decades of life. This disease is treated by the revascularization of the affected organs either by surgery or by endovascular interventions. In this study, we present a case where renal autotransplantation was performed on a lady with an autologous saphenous vein graft subsequent to numerous previous endovascular interventions for her solitary kidney due to Takayasu arteritis-induced renal artery stenosis...
May 10, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/28485834/profile-and-outcomes-of-women-with-pregnancy-related-acute-kidney-injury-requiring-dialysis-at-a-center-in-ethiopia
#19
Delayehu Bekele, Momina Ahmed, Ahmed Ibrahim, Seman Kedir, Grace Chan
OBJECTIVE: To describe the clinical profile and outcomes of women with pregnancy-related acute kidney injury (AKI) undergoing dialysis at Saint Paul's Hospital Millennium Medical College, Addis Ababa, where the first publicly funded large-scale dialysis service in Ethiopia was established. METHODS: In a hospital-based retrospective study, clinical records were reviewed for all women with pregnancy-related AKI attending the hemodialysis unit at the study center between August 2013 and July 2015...
May 9, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28485097/hematopoietic-stem-cell-transplantation-and-acute-kidney-injury-in-children-a-comprehensive-review
#20
REVIEW
Rupesh Raina, Nicholas Herrera, Vinod Krishnappa, Sidharth Kumar Sethi, Akash Deep, Wei-Ming Kao, Timothy Bunchman, Rolla Abu-Arja
AKI in the setting of HSCT is commonly investigated among adult patients. In the same way, malignancies requiring treatment with HSCT are not limited to the adult patient population, AKI following HSCT is frequently encountered within pediatric patient populations. However, inadequate information regarding epidemiology and pathophysiology specific to pediatric patients prevents development of appropriate and successful therapeutic strategies for those afflicted. Addressing AKI in the context of sinusoidal obstruction syndrome, chemotherapy, thrombotic microangiopathy and hypertension post chemotherapy, glomerulonephritis, and graft versus host disease provides greater insight into renal impairment associated with these HSCT-related ailments...
June 2017: Pediatric Transplantation
keyword
keyword
102198
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"