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https://www.readbyqxmd.com/read/28822830/chronic-kidney-disease-in-long-term-survivors-after-allogeneic-hematopoietic-stem-cell-transplantation-retrospective-analysis-at-a-single-institute
#1
Tomoyasu Jo, Yasuyuki Arai, Tadakazu Kondo, Toshiyuki Kitano, Masakatsu Hishizawa, Kouhei Yamashita, Akifumi Takaori-Kondo
The number of patients eligible for allogeneic stem cell transplantation (allo-HSCT) has increased because of improvements in transplantation procedures. Among long-term survivors of allo-HSCT, chronic kidney disease (CKD) is a major cause of morbidity. We retrospectively analyzed the clinical data of 106 consecutive patients with a median age of 43 (17-73) years who had undergone allo-HSCT at our institution between January 2001 and September 2009. Patients who died within 5 years after transplantation or had CKD at the time of transplantation were excluded in this study...
August 16, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28819712/optical-coherence-tomography-to-differentiate-papilledema-from-pseudopapilledema
#2
REVIEW
Gema Rebolleda, Aki Kawasaki, Victoria de Juan, Noelia Oblanca, Francisco Jose Muñoz-Negrete
PURPOSE OF REVIEW: Mild papilledema may be difficult to distinguish by clinical observation from pseudopapilledema. An accurate diagnosis is critical to avoid invasive workup and unwarranted treatment. In this review, we focus on the development and subsequent role of optical coherence tomography (OCT) in detecting and differentiating optic nerve head drusen (ONHD) from papilledema and other causes of acquired swelling of the optic disc. RECENT FINDINGS: Newer OCT technologies which permit deeper penetration to improve detection of ONHD were also reviewed...
August 17, 2017: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/28819079/-an-adult-case-of-enterovirus-d68-encephalomyelitis-presenting-as-bilateral-facial-nerve-palsy-and-dysphagia
#3
Yuta Kusabe, Akari Takeshima, Azusa Seino, Mana Nishida, Mami Takahashi, Shota Yamada, Junsuke Shimbo, Aki Sato, Kouichirou Okamoto, Shuichi Igarashi
A 33-year-old man was admitted to our hospital with bilateral facial nerve paralysis, dysphagia, and muscle weakness in the neck and trunk following fever, headache and throat pain. T<sub>2</sub>-weighted brain magnetic resonance imaging (MRI) showed hyperintense lesions in the tegmentum of the brain stem and the ventral region of the superior cervical cord. Based on the characteristic findings on the brain MRI, we diagnosed the patient with enteroviral encephalomyelitis. Steroid therapy was administered; however, his bilateral facial nerve paralysis and dysphagia were refractory to this therapy...
August 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/28814591/spleno-renal-artery-transposition-in-a-solitary-functioning-kidney-for-treatment-resistant-hypertension-and-acute-kidney-injury
#4
Subash Somalanka, Fiona E Harris, Eric Chemla, Rebecca Jo Suckling, Pauline A Swift
Renal Artery Stenosis (RAS) is an important cause of treatment-resistant hypertension. Uncontrolled hypertension with RAS can cause progressive chronic kidney disease (CKD) leading to end-stage kidney disease. Therapeutic revascularisation can be helpful in appropriate circumstances where pharmaceutical intervention has failed and significant renovascular disease contributes to resistant hypertension. We present an interesting case of a Caucasian male with peripheral vasculopathy, abdominal aortic aneurysm (AAA), single functioning kidney and ostial RAS caused by stent struts from an endovascular AAA stent graft...
August 16, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28807932/reducing-inflammatory-cytokine-production-from-renal-collecting-duct-cells-by-inhibiting-gata2-ameliorates-acute-kidney-injury
#5
Lei Yu, Takashi Moriguchi, Hiroshi Kaneko, Makiko Hayashi, Atsushi Hasegawa, Masahiro Nezu, Hideyuki Saya, Masayuki Yamamoto, Ritsuko Shimizu
Acute kidney injury (AKI) is a leading cause of chronic kidney disease. Proximal tubules are considered to be the primary origin of pathogenic inflammatory cytokines in AKI. However, it remains unclear whether other cell types, including collecting duct (CD) cells, participate in inflammatory processes. The transcription factor GATA2 is specifically expressed in CD cells and maintains their cellular identity. To explore the pathophysiological function of GATA2 in AKI, we generated renal tubular cell-specific Gata2 deletion (G2CKO) mice and examined their susceptibility to ischemia-reperfusion injury (IRI)...
August 14, 2017: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/28806959/second-line-therapy-for-helicobacter-pylori-eradication-causing-antibiotic-associated-hemorrhagic-colitis
#6
Kazuyuki Tanaka, Mikihiro Fujiya, Aki Sakatani, Shugo Fujibayashi, Yoshiki Nomura, Nobuhiro Ueno, Shin Kashima, Takuma Goto, Junpei Sasajima, Kentaro Moriichi, Toshikatsu Okumura
OBJECTIVE: Helicobacter pylori (H. pylori) eradication rarely develops into antibiotic-associated hemorrhagic colitis (AAHC), in which the etiology of colitis remains unclear. We herein report a rare case of AAHC caused by second-line therapy for H. pylori eradication. RESULTS: A 65-year-old female was administered second-line therapy for H. pylori composed of 1500 mg of amoxicillin, 500 mg of metronidazole and 40 mg of vonoprazan for 7 days because of first-line therapy failure...
August 14, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28802086/acute-kidney-injury-is-common-with-intravenous-abuse-of-extended-release-oral-oxymorphone-and-delayed-renal-recovery-rates-are-associated-with-increased-kdigo-staging
#7
Alex K Bonnecaze, Matthew Whitaker Wilson, Ajay Dharod, Alison Fletcher, P J Miller
BACKGROUND: Prescription opioid abuse poses a serious problem in the United States, representing 615 per 100,000 deaths annually. Extended-release oxymorphone (Opana-ER) is an oral opioid pain medication that has recently been found to cause thrombotic microangiopathy when intravenously abused. In this retrospective study, prevalence and outcomes of AKI among patients intravenously abusing extended-release oral oxymorphone were analyzed. METHODS: A query of electronic medical records for "drug abuse" at an academic medical center during January 2012 to December 2015 was performed and yielded 2350 patients...
August 12, 2017: Nephrology
https://www.readbyqxmd.com/read/28795480/hospital-teaching-status-and-trascatheter-aortic-valve-replacement-outcomes-in-the-united-states-analysis-of-the-national-inpatient-sample
#8
Tesfaye Telila, Emmanuel Akintoye, Tomo Ando, Obsinet Merid, Mohan Palla, Sagar Mallikethi-Reddy, Alexandros Briasoulis, Cindy Grines, Luis Afonso
BACKGROUND: Evidence suggests that medical service offerings vary by hospital teaching status. However, little is known about how these translate to patient outcomes. We therefore sought to evaluate this gap in knowledge in patients undergoing Transcatheter aortic valve replacement (TAVR) in the United States. METHODS: This study was conducted using the National Inpatient Sample (NIS) in the United States from 2011 to 2014. Teaching status was classified, as teaching vs...
August 10, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28794136/neutrophil-gelatinase-associated-lipocalin-prior-to-cardiac-surgery-predicts-acute-kidney-injury-and-mortality
#9
Heerajnarain Bulluck, Raju Maiti, Bibhas Chakraborty, Luciano Candilio, Tim Clayton, Richard Evans, David P Jenkins, Shyam Kolvekar, Gudrun Kunst, Christopher Laing, Jennifer Nicholas, John Pepper, Derek M Yellon, Derek J Hausenloy
OBJECTIVE: We aimed to investigate whether preoperative serum neutrophil gelatinase-associated lipocalin (sNGALpre-op) predicted postoperative acute kidney injury (AKI) during hospitalisation and 1-year cardiovascular and all-cause mortality following adult cardiac surgery. METHODS: This study was a post hoc analysis of the Effect of Remote Ischemic Preconditioning on Clinical Outcomes in Patient Undergoing Coronary Artery Bypass Graft Surgery trial involving adult patients undergoing coronary artery bypass graft...
August 9, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28792165/acute-stylet-peritoneal-dialysis-in-acute-kidney-injury-the-soul-never-dies
#10
Amith Vijay Leon D'Souza, Nishad Raveendran, Rajendra Singh Tanwar, Piyush Kimmatkar, Pankaj Beniwal, Dhananjai Agarwal, Vinay Vinay
BACKGROUND: Acute Kidney Injury (AKI) has a significant mortality rate. In developing countries, mortality due to AKI is high due to lack of access to dialysis facilities and related cost. The main goal of International Society of Nephrology (ISN) 0 by 25 initiative is to eliminate deaths due to AKI. Peritoneal dialysis is an underutilized modality in such a scenario. The aim of this study was to look into effectiveness of starting Acute stylet Peritoneal Dialysis (PD) in a resource constraint settings...
July 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28791128/the-first-japanese-patient-with-mandibular-hypoplasia-deafness-progeroid-features-and-lipodystrophy-diagnosed-via-pold1-mutation-detection
#11
Asami Okada, Tomohiro Kohmoto, Takuya Naruto, Ichiro Yokota, Yumiko Kotani, Aki Shimada, Yoko Miyamoto, Rizu Takahashi, Aya Goji, Kiyoshi Masuda, Shoji Kagami, Issei Imoto
Mandibular hypoplasia, deafness, progeroid features and lipodystrophy (MDPL) syndrome is a rare autosomal dominant disorder caused by heterozygous POLD1 mutations. To date, 13 patients affected by POLD1 mutation-caused MDPL have been described. We report a clinically undiagnosed 11-year-old male who noted joint contractures at 6 years of age. Targeted exome sequencing identified a known POLD1 mutation [NM_002691.3:c.1812_1814del, p.(Ser605del)] that diagnosed him as the first Japanese/East Asian MDPL case.
2017: Human Genome Variation
https://www.readbyqxmd.com/read/28783657/plasmodium-products-persist-in-the-bone-marrow-and-promote-chronic-bone-loss
#12
Michelle S J Lee, Kenta Maruyama, Yukiko Fujita, Aki Konishi, Patrick M Lelliott, Sawako Itagaki, Toshihiro Horii, Jing-Wen Lin, Shahid M Khan, Etsushi Kuroda, Shizuo Akira, Ken J Ishii, Cevayir Coban
Although malaria is a life-threatening disease with severe complications, most people develop partial immunity and suffer from mild symptoms. However, incomplete recovery from infection causes chronic illness, and little is known of the potential outcomes of this chronicity. We found that malaria causes bone loss and growth retardation as a result of chronic bone inflammation induced by Plasmodium products. Acute malaria infection severely suppresses bone homeostasis, but sustained accumulation of Plasmodium products in the bone marrow niche induces MyD88-dependent inflammatory responses in osteoclast and osteoblast precursors, leading to increased RANKL expression and overstimulation of osteoclastogenesis, favoring bone resorption...
June 2, 2017: Science Immunology
https://www.readbyqxmd.com/read/28775000/bpi-fold-containing-family-a-member-2-parotid-secretory-protein-is-an-early-biomarker-of-aki
#13
Satya K Kota, Elizabeth Pernicone, David E Leaf, Isaac E Stillman, Sushrut S Waikar, Savithri Balasubramanian Kota
AKI is a major cause of morbidity and mortality and an important contributor to the development and progression of CKD. Molecular biomarkers that improve the detection and prognostication of AKI are therefore required. We assessed the utility as such of BPI fold-containing family A member 2 (BPIFA2), also known as parotid secretory protein, which we identified via a multiplex quantitative proteomics screen of acutely injured murine kidneys. In physiologic conditions, BPIFA2 is expressed specifically in the parotid glands and is abundant in salivary secretions...
August 3, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28770412/essential-elements-as-biomarkers-of-acute-kidney-injury-and-spontaneous-reversion
#14
Regiane Marinho da Silva, Gui Mi Ko, Rinaldo Florêncio Silva, Ludmila Cabreira Vieira, Rafael Vicente de Paula, Júlio Takehiro Marumo, Amanda Ikegami, Maria Helena Bellini
Acute kidney injury (AKI) is an important health problem and can be caused by number of factors. The use of aminoglycosides, such as gentamicin, is one of these factors. Recently, an effort has been made to find biomarkers to guide treatment protocols. Inductively coupled plasma optical emission spectroscopy (ICP-OES) was used to estimate the contents of Ca, Cu, Fe, K, Mg, Mn, Na, P, and Zn in serum and urine of the healthy, AKI, and spontaneous recovery (SR) groups of animals. The animal model of AKI and SR was validated by measuring serum and urinary urea and creatinine...
August 2, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28768971/acute-renal-failure-with-severe-loin-pain-and-patchy-renal-vasoconstriction-in-a-patient-without-hypouricemia-provoked-by-epileptic-seizure
#15
Michitaka Maekawa, Takahiro Imaizumi, Taishi Yamakawa, Yasuhiko Ito
A 26-year-old Japanese man without hypouricemia and with 3 previous episodes of seizures concurrent with acute kidney injury (AKI) was admitted due to an epileptic seizure, lower back pain and AKI. His creatinine kinase levels were slightly elevated. Patchy renal ischemia on contrast-enhanced computed tomography and persistent residual contrast medium was observed, consistent with acute renal failure with severe loin pain and patchy renal ischemia after anaerobic exercise (ALPE). Diffusion-weighted imaging (DWI) demonstrated signal changes in the corresponding area...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28764919/effects-of-higher-quality-of-care-on-initiation-of-long-term-dialysis-in-patients-with-ckd-and-diabetes
#16
Hon-Yen Wu, Shingo Fukuma, Sayaka Shimizu, Edward C Norton, Yu-Kang Tu, Kuan-Yu Hung, Mei-Ru Chen, Kuo-Liong Chien, Shunichi Fukuhara
BACKGROUND: The burden of diabetes-related chronic kidney disease (CKD) on individuals and society is increasing, shifting attention toward improving the quality of care for patients with CKD and diabetes. We assessed the quality of CKD care and its association with long-term dialysis, acute kidney injury (AKI), and death. STUDY DESIGN: Retrospective cohort study (2004-2011). SETTING & PARTICIPANTS: Adults in Taiwan with incident CKD enrolled in the Longitudinal Cohort of Diabetes Patients...
July 29, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28764659/non-steroidal-anti-inflammatory-drug-induced-acute-kidney-injury-in-the-community-dwelling-general-population-and-people-with-chronic-kidney-disease-systematic-review-and-meta-analysis
#17
Xinyu Zhang, Peter T Donnan, Samira Bell, Bruce Guthrie
BACKGROUND: Non-steroidal anti-inflammatory drugs (NSAIDs) are a common cause of adverse drug events (ADEs), but renal risks of NSAIDs are less well quantified than gastrointestinal and cardiac risks. This paper reports a systematic review of published population-based observational studies examining the risk of acute kidney injury (AKI) associated with NSAIDs in community-dwelling adults and those with pre-existing chronic kidney disease (CKD). METHODS: MEDLINE and EMBASE databases were searched until June 2016, and 3789 papers screened...
August 1, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28762841/haematuria-is-a-marker-for-the-severity-of-acute-kidney-injury-but-does-not-associate-with-thrombocytopenia-in-acute-puumala-hantavirus-infection
#18
Tuula K Outinen, Paula Mantula, Outi K Laine, Ilkka Pörsti, Antti Vaheri, Satu M Mäkelä, Jukka Mustonen
BACKGROUND: Puumala hantavirus (PUUV) causes haemorrhagic fever with renal syndrome characterized by thrombocytopenia, capillary leakage and acute kidney injury (AKI) with proteinuria and haematuria. Although the typical histologic lesion is acute tubulointerstitial nephritis, the amount of glomerular proteinuria predicts the severity of upcoming AKI. Here, we studied the associations of haematuria and proteinuria with the severity of emerging AKI, thrombocytopenia and markers of coagulation and fibrinolysis in PUUV infection...
August 1, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/28761238/dengue-fever-induced-thrombotic-microangiopathy-an-unusual-cause-of-renal-failure
#19
V Bhargava, P Gupta, R Kauntia, G Bajpai
Dengue fever is a tropical infection, which is mosquito-borne disease, caused by dengue virus and spread by Aedes mosquitoes. The incidence of dengue fever has risen rapidly over the past few years. About half of dengue infections are asymptomatic, and a great majority present with fever and body ache. However, the occurrence of complications is well known, including acute kidney injury (AKI). AKI in dengue is usually attributable to a pre-renal cause. Thrombotic microangiopathy is an extremely rare complication of dengue fever, with only a few published case reports in medical literature...
July 2017: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/28761227/acute-kidney-injury-in-pregnancy-specific-disorders
#20
REVIEW
J Prakash, V C Ganiger
The incidence of acute kidney injury in pregnancy (P-AKI) has declined significantly over the last three decades in developing countries. However, it is still associated with significant fetomaternal mortality and morbidity. The diagnosis of P-AKI is based on the serum creatinine increase. The usual formulas for estimating glomerular filtration rate (GFR) are not validated in this population. The incidence of P-AKI with respect to total AKI cases has decreased in the last three decades from 25% in 1980s to 9% in 2000s at our centre...
July 2017: Indian Journal of Nephrology
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