Keri Oxendine Harp, Alaijah Bashi, Felix Botchway, Daniel Addo-Gyan, Mark Tetteh-Tsifoanya, Amanda Lamptey, Georgina Djameh, Shareen A Iqbal, Cecilia Lekpor, Saswati Banerjee, Michael D Wilson, Yvonne Dei-Adomakoh, Andrew A Adjei, Jonathan K Stiles, Adel Driss
Malaria affects a significant portion of the global population, with 247 million cases in 2021, primarily in Africa. However, certain hemoglobinopathies, such as sickle cell trait (SCT), have been linked to lower mortality rates in malaria patients. Hemoglobin (Hb) mutations, including HbS and HbC, can cause sickle cell disease (SCD) when both alleles are inherited (HbSS and HbSC). In SCT, one allele is inherited and paired with a normal allele (HbAS, HbAC). The high prevalence of these alleles in Africa may be attributed to their protective effect against malaria...
April 19, 2023: International Journal of Molecular Sciences