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https://www.readbyqxmd.com/read/29350370/operative-and-non-operative-management-of-children-with-abdominal-gunshot-injuries
#1
Mehmet Şerif Arslan, Hikmet Zeytun, Serkan Arslan, Erol Basuguy, Mehmet Hanifi Okur, Bahattin Aydoğdu, Cemil Göya, İbrahim Uygun, Selçuk Otçu
BACKGROUND: Non-operative management (NOM) is a standard treatment method for solid organ injuries worldwide. There is no consensus on the management of gunshot wounds (GSW) because of the higher frequency of hollow viscus injuries (HVI) and the unpredictable depth of tissue damage produced by kinetic energy transfer during retardation of the bullet. Here we aimed to reevaluate indications for surgery and NOM based on our pediatric patients with abdominal GSW. METHODS: We performed a retrospective analysis of patients evaluated and treated for abdominal GSW at University of Dicle between January 2010 and October 2016...
January 2018: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/29348317/head-to-head-comparison-of-11c-pbr28-and-18f-ge180-for-the-quantification-of-tspo-in-the-human-brain
#2
Paolo Zanotti-Fregonara, Belen Pascual, Gaia Rizzo, Meixiang Yu, Neha Pal, David Beers, Randall Carter, Stanley Appel, Nazem Atassi, Joseph Masdeu
Introduction:18F-GE180 is a third-generation positron emission tomography (PET) tracer to quantify the translocator protein TSPO, a biomarker for inflammation. The aim of this study was to compare head-to-head 18F-GE180 to the well-established translocator protein (TSPO) tracer 11C-PBR28, by scanning with either tracer during the same day in the same subjects. Materials and Methods: Five subjects underwent a 90-minute PET scan with 11C-PBR28 in the morning and 18F-GE180 in the afternoon. A metabolite-corrected arterial input function was obtained in each subject for both tracers, and the brain uptake was quantified with a two-tissue compartmental model...
January 18, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29335032/-sit-and-tilt-preparation-for-subscapular-system-free-flaps
#3
J Mark, H Patwa, M S Costello, Y Patil
BACKGROUND: The ablation of advanced head and neck cancer often results in large three-dimensional defects that require free tissue transfer to optimally address functional and cosmetic issues. The subscapular system is a highly versatile donor site for flaps used for head and neck reconstruction. Traditional methods of harvesting subscapular flaps require repositioning and re-preparing, which significantly increases the operative time and prevents simultaneous harvesting of the flap...
January 16, 2018: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/29330531/low-density-neutrophils-ldn-in-postoperative-abdominal-cavity-assist-the-peritoneal-recurrence-through-the-production-of-neutrophil-extracellular-traps-nets
#4
Rihito Kanamaru, Hideyuki Ohzawa, Hideyo Miyato, Shiro Matsumoto, Hidenori Haruta, Kentaro Kurashina, Shin Saito, Yoshinori Hosoya, Hironori Yamaguchi, Hiroharu Yamashita, Yasuyuki Seto, Alan Kawarai Lefor, Naohiro Sata, Joji Kitayama
Many types of immune cells appear in peritoneal cavity after abdominal surgery. In patients who underwent laparotomy due to gastric cancer, peritoneal lavages were obtained before and after surgical procedure. Cells were recovered from intermediate layer after Ficoll-Hypaque centrifugation and analyzed for phenotypes and functions, especially focused on low density neutrophils (LDN). The number of CD66b (+) LDN with mature phenotype was markedly elevated in postoperative as compared with preoperative lavages...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29323267/scaffold-free-generation-of-uniform-adipose-spheroids-for-metabolism-research-and-drug-discovery
#5
Aloysius J Klingelhutz, Francoise A Gourronc, Anna Chaly, David A Wadkins, Anthony J Burand, Kathleen R Markan, Sharon O Idiga, Meng Wu, Matthew J Potthoff, James A Ankrum
Adipose tissue dysfunction is critical to the development of type II diabetes and other metabolic diseases. While monolayer cell culture has been useful for studying fat biology, 2D culture often does not reflect the complexity of fat tissue. Animal models are also problematic in that they are expensive, time consuming, and may not completely recapitulate human biology because of species variation. To address these problems, we have developed a scaffold-free method to generate 3D adipose spheroids from primary or immortal human or mouse pre-adipocytes...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29322559/cest-dixon-for-human-breast-lesion-characterization-at-3-t-a-preliminary-study
#6
Shu Zhang, Stephen Seiler, Xinzeng Wang, Ananth J Madhuranthakam, Jochen Keupp, Emily E Knippa, Robert E Lenkinski, Elena Vinogradov
PURPOSE: Chemical exchange saturation transfer (CEST) MRI for breast lesion characterization is promising. However, artifacts are prone to develop in breast CEST imaging as a result of strong lipid signals. The aims of the study are (i) to develop and validate the CEST-Dixon imaging sequence for simultaneous water-fat separation and B0 mapping; and (ii) use the CEST-Dixon method to characterize suspicious lesions in patients undergoing percutaneous biopsy. METHODS: The gradient-echo multi-echo Dixon acquisition is used to create fat-free CEST and B0 maps...
January 10, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29322547/improvement-of-the-salvage-rate-of-flap-after-venous-thrombosis-with-intraparenchymatous-venous-pressure-monitoring
#7
Hajime Matsumine, Mariko Mogami, Osamu Fujiwara, Masahiro Hasegawa, Hiroshi Ito, Hiroyuki Sakurai
PURPOSE: Intraparenchymatous venous pressure (IVP) monitoring in flap can measure venous pressure with catheter placement. Among patients with IVP monitoring, this study reviewed postoperative microvascular complications for investigating the transplanted-tissue salvage-rate. PATIENTS AND METHODS: Two hundred and seventy-one patients (male, 132; female, 139; mean age, 52.3 years; age range, 9-82 years) underwent free flap transfer and postoperative continuous IVP monitoring, which performed as follows; a venous catheter was connected to a transducer, and venous pressure in the flap was recorded for three consecutive days postoperatively...
January 11, 2018: Microsurgery
https://www.readbyqxmd.com/read/29314488/fabrication-of-thermosensitive-cyclic-brush-copolymer-with-enhanced-therapeutic-efficacy-for-anticancer-drug-delivery
#8
Xiao-Yan Tu, Chao Meng, Yun-Fei Wang, Li-Wei Ma, Bao-Yan Wang, Jin-Lin He, Pei-Hong Ni, Xiang-Ling Ji, Ming-Zhu Liu, Hua Wei
Adaptation of cyclic brush polymer for drug delivery applications remains largely unexplored. Herein, cyclic brush copolymer of poly(2-hydroxyethyl methacrylate-g-poly(N-isopropylacrylamide-st-N-hydroxyethylacrylamide)) (cb-P(HEMA-g-P(NIPAAm-st-HEAAm))), comprising a cyclic core of PHEMA and thermosensitive brushes of statistical copolymer of P(NIPAAm-st-HEAAm), is designed and synthesized successfully via a graft-from approach using atom transfer free radical polymerization from a cyclic multimacroinitiator...
January 4, 2018: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/29290568/outcome-predictors-in-elderly-head-and-neck-free-flap-reconstruction-a-retrospective-study-and-systematic-review-of-the-current-evidence
#9
Cindy Siaw-Lin Goh, Yee-Onn Kok, Cheryl Pei-Chyi Yong, Esther Wan-Xian Tan, Lee-Gan Goh, Khong-Yik Chew, Constance Ee-Hoon Teo, Terence Lin-Hon Goh
Free flap tissue transfer has become the gold standard for reconstruction of composite head and neck defects. We sought to investigate the efficacy and morbidity of these procedures in the elderly. We retrospectively reviewed 245 head and neck free flap procedures (234 patients). Patients were stratified by age group (≥ or <65 years). Univariate and multivariate analyses were used to evaluate the following primary outcomes - free flap survival, postoperative medical and surgical complications and 30-day mortality...
December 12, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29284987/efficient-regeneration-system-for-rapid-multiplication-of-clean-planting-material-of-ensete-ventricosum-welw-cheesman
#10
Jaindra Tripathi, Jonathan Matheka, Ibsa Merga, Endale Gebre, Leena Tripathi
Enset (Ensete ventricosum (Welw.) Cheesman) is an economically important staple food crop in Ethiopia, especially in the southern and southwestern regions. It is called "false banana" due to its resemblance to banana, but inability to produce any edible fruit. The crop is clonally propagated using field-grown suckers. This study reports the development of a robust regeneration technique to propagate large numbers of plantlets using corm discs containing intercalary meristematic tissues. Hundreds of shoot buds were induced from corm discs of enset cultivar 'Bedadeti' cultured on Murashige and Skoog (MS) medium supplemented with 1...
2017: In Vitro Cellular & Developmental Biology. Plant: Journal of the Tissue Culture Association
https://www.readbyqxmd.com/read/29284163/geometric-three-dimensional-end-to-side-microvascular-anastomosis-a-simple-and-reproducible-technique
#11
Adrian S H Ooi, Daniel R Butz, Sean M Fisher, Zachary J Collier, Lawrence J Gottlieb
BACKGROUND:  End-to-side (ETS) anastomoses are useful when preservation of distal vascularity is critical. The ideal ETS microanastomosis should maintain a wide aperture and have a smooth take-off point to minimize turbulence, vessel spasm, and thrombogenicity of the suture line. We have developed a unique, dependable, and reproducible geometric technique for ETS anastomoses, and analyze its efficacy in our series of patients. METHODS:  The geometric ETS technique involves creating a three-dimensional (3D) diamond-shaped defect on the recipient vessel wall, followed by a slit incision of the donor vessel to create a "spatula" fitting this defect...
December 28, 2017: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/29225198/perspective-in-optimization-of-stem-cell-therapies-for-heart-regeneration
#12
Paulina Gapska, Maciej Kurpisz
There is a variety of mechanisms(s) factor(s) that may influence stem cell therapies for heart regeneration. Among the best candidates for stem cell source are: mesenchymal stem cells (also those isolated from adipose tissue), cardiac cell progenitors (CPC) and descendants of iPSC cells. iPSC/s can be potentially beneficial although their pluripotent induction has been still in question due to: low propagation efficacy, danger of genomic integration/instability, biological risk of current vector system teratoma formation etc...
December 7, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/29224822/head-and-neck-reconstruction-with-free-flaps-based-on-the-thoracodorsal-system
#13
John Edward O'Connell, Mandeep S Bajwa, Andrew G Schache, Richard J Shaw
The advent or micro-vascular free tissue transfer has facilitated the reconstruction of increasingly complex head and neck defects. There are multiple donor sites available, each with its' own advantages and disadvantages. However, the subscapular system, including the thoracodorsal system, provides the widest array of soft tissue and osseous flaps, as well as chimeric options. Its advantages include a long pedicle, independently mobile tissue components, relative sparing from atherosclerosis, and minimal donor site morbidity...
December 2017: Oral Oncology
https://www.readbyqxmd.com/read/29224818/reconstruction-after-salvage-laryngectomy
#14
David H Yeh, Axel Sahovaler, Kevin Fung
Both early and advanced stage laryngeal cancers are treated with organ-preserving strategies including radiation alone or concurrent chemoradiotherapy. While organ-preserving modalities have proven effective in eradicating cancer while also preserving laryngeal function, there remains a proportion of cases where residual or recurrent cancer prevails, or conversely, where radiotherapy renders a larynx dysfunctional. In these circumstances, salvage total laryngectomy is often the surgical treatment. The effects of radiotherapy to the neck, amplified by chemotherapy, can create an inhospitable surgical environment, making the salvage laryngectomy an operation fraught with the potential for major complications such as the dreaded pharyngocutaneous fistula...
December 2017: Oral Oncology
https://www.readbyqxmd.com/read/29223890/gold-core-ceria-shell-based-redox-active-nanozyme-mimicking-the-biological-multienzyme-complex-phenomenon
#15
Stuti Bhagat, N V Srikanth Vallabani, Vaithiyalingam Shutthanandan, Mark Bowden, Ajay S Karakoti, Sanjay Singh
Catalytically active individual gold (Au) and cerium oxide (CeO2) nanoparticles (NPs) are well known to exhibit specific enzyme-like activities, such as natural catalase, oxidase, superoxide dismutase, and peroxidase enzymes. These activities have been maneuvered to design several biological applications such as immunoassays, glucose detection, radiation and free radical protection and tissue engineering. In biological systems, multienzyme complexes are involved in catalyzing important reactions of essential metabolic processes such as respiration, biomolecule synthesis, and photosynthesis...
December 7, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29221445/study-protocol-of-hgcsg1404-snow-study-a-phase-i-ii-trial-of-combined-chemotherapy-of-s-1-nab-paclitaxel-and-oxaliplatin-administered-biweekly-to-patients-with-advanced-gastric-cancer
#16
Yasuyuki Kawamoto, Yoshito Komatsu, Satoshi Yuki, Kentaro Sawada, Tetsuhito Muranaka, Kazuaki Harada, Hiroshi Nakatsumi, Hiraku Fukushima, Atsushi Ishiguro, Masayoshi Dazai, Kazuteru Hatanaka, Michio Nakamura, Ichiro Iwanaga, Minoru Uebayashi, Susumu Sogabe, Yoshimitsu Kobayashi, Takuto Miyagishima, Kota Ono, Naoya Sakamoto, Yuh Sakata
BACKGROUND: In Japan, S-1 plus cisplatin (SP) regimen has become a standard therapy for patients with advanced gastric cancer. Moreover, the S-1 plus oxaliplatin regimen is now a standard treatment. Nab-paclitaxel was developed for chemotherapy of gastric cancer in Japanese clinical practice. Nab-paclitaxel, created with albumin-bound paclitaxel particles, has high transferability to tumour tissues and does not cause hypersensitivity reactions because of a different chemical composition compared with docetaxel and paclitaxel...
December 8, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29220150/functionalized-eu-iii-based-nanoscale-metal-organic-framework-to-achieve-near-ir-triggered-and-targeted-two-photon-absorption-photodynamic-therapy
#17
Jianguo Jia, Yang Zhang, Min Zheng, Changfu Shan, Huicheng Yan, Wenyu Wu, Xuan Gao, Bo Cheng, Weisheng Liu, Yu Tang
The postsynthetic-modified nanoscale metal-organic framework (NMOF) probes selected as potential drug delivery platforms and photodynamic therapy agents to fulfill the effective and safe treatment of neoplastic diseases have attracted increasing attention recently. Herein, a Eu(III)-based NMOF probe elaborately postsynthetically modified with a β-diketonate two-photon-absorbing (TPA) ligand is rationally designed and further functionalized by assembling the photosensitizer molecule (methylene blue, MB) in the pores and a cyclic peptide targeting motif on the surface of the NMOF, which could achieve highly efficient near-infrared (NIR)-triggered and -targeted photodynamic therapy (PDT)...
December 8, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29218109/rational-lung-tissue-and-animal-models-for-rapid-breath-tests-to-determine-pneumonia-and-pathogens
#18
Yong Zhou, Enguo Chen, Xiaohong Wu, Yanjie Hu, Huiqing Ge, Peifeng Xu, Yingchang Zou, Joy Jin, Ping Wang, Kejing Ying
OBJECTIVE: This study works to develop novel models that may be adopted for earlier non-invasive breathomics tests to determine pneumonia pathogens. METHODS: Two types of pneumonia models were created, both in vitro and in vivo. Paraneoplasm lung tissue and specific pathogen-free (SPF) rabbits were adopted and separately challenged with sterile saline solution control or three pathogens: Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. After inoculation, headspace air or exhaled air were absorbed by solid phase micro-extraction (SPME) fibers and subsequently analyzed with gas chromatograph Mass Spectrometer (GCMS)...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29201621/thermal-release-transfer-printing-for-stretchable-conformal-bioelectronics
#19
Zhuocheng Yan, Taisong Pan, Miaomiao Xue, Changyong Chen, Yan Cui, Guang Yao, Long Huang, Feiyi Liao, Wei Jing, Hulin Zhang, Min Gao, Daqing Guo, Yang Xia, Yuan Lin
Soft neural electrode arrays that are mechanically matched between neural tissues and electrodes offer valuable opportunities for the development of disease diagnose and brain computer interface systems. Here, a thermal release transfer printing method for fabrication of stretchable bioelectronics, such as soft neural electrode arrays, is presented. Due to the large, switchable and irreversible change in adhesion strength of thermal release tape, a low-cost, easy-to-operate, and temperature-controlled transfer printing process can be achieved...
November 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/29201370/salvage-of-mangled-upper-extremity-using-the-masquelet-technique-in-a-child-a-case-report
#20
Nabil Alassaf, Amro Alhoukail, Abdullah Alsahli, Ghazi Althubaiti
Aim: To report our experience with the Masquelet concept in a pediatric upper extremity following an open injury to the elbow. Methods: A case report and literature review. Results: An 11-year-old boy was transferred to our institution after a motor vehicle collision. There was a primary loss of the ulnohumeral articulation and the surrounding soft tissues as well as the ulnar nerve. Reconstruction used the Masquelet-induced membrane technique and a soft tissue flap...
2017: SAGE Open Medical Case Reports
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