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lung quantification

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https://www.readbyqxmd.com/read/28629554/emphysema-quantification-and-lung-volumetry-in-chest-x-ray-equivalent-ultralow-dose-ct-intra-individual-comparison-with-standard-dose-ct
#1
Michael Messerli, Thorsten Ottilinger, René Warschkow, Sebastian Leschka, Hatem Alkadhi, Simon Wildermuth, Ralf W Bauer
OBJECTIVES: To determine whether ultralow dose chest CT with tin filtration can be used for emphysema quantification and lung volumetry and to assess differences in emphysema measurements and lung volume between standard dose and ultralow dose CT scans using advanced modeled iterative reconstruction (ADMIRE). METHODS: 84 consecutive patients from a prospective, IRB-approved single-center study were included and underwent clinically indicated standard dose chest CT (1...
June 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28625647/quantification-of-growth-patterns-of-screen-detected-lung-cancers-the-nelson-study
#2
Marjolein A Heuvelmans, Rozemarijn Vliegenthart, Harry J de Koning, Harry J M Groen, Michel J A M van Putten, Uraujh Yousaf-Khan, Carla Weenink, Kristiaan Nackaerts, Pim A de Jong, Matthijs Oudkerk
OBJECTIVES: Although exponential growth is assumed for lung cancer, this has never been quantified in vivo. Aim of this study was to evaluate and quantify growth patterns of lung cancers detected in the Dutch-Belgian low-dose computed tomography (CT) lung cancer screening trial (NELSON), in order to elucidate the development and progression of early lung cancer. MATERIALS AND METHODS: Solid lung nodules found at ≥3 CT examinations before lung cancer diagnosis were included...
June 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28623874/lansoprazole-sulphide-pharmacokinetics-of-this-promising-anti-tuberculous-agent
#3
Sipho Mdanda, Sooraj Baijnath, Adeola Shobo, Sanil D Singh, Glenn E M Maguire, Hendrik G Kruger, Per I Arvidsson, Tricia Naicker, Thavendran Govender
Lansoprazole (LPZ) is a commercially available proton-pump inhibitor (PPI) whose primary metabolite, lansoprazole sulphide (LPZS) was recently reported to have in vitro and in vivo activity against M. tb. It was also reported that a 300 mg kg(-1) oral administration of LPZS was necessary to reach therapeutic levels in the lung, with the equivalent human dose being unrealistic. A validated liquid chromatography-tandem mass spectrometric method (LC-MS/MS) for the simultaneous quantification LPZ and LPZS in rat plasma and lung homogenates, was developed...
June 17, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28622369/comparative-sequence-analysis-reveals-regulation-of-genes-in-developing-schistosomula-of-schistosoma-mansoni-exposed-to-host-portal-serum
#4
Wander de Jesus Jeremias, Flávio Marcos Gomes Araújo, Fábio Ribeiro Queiroz, Fabiano Sviatopolk Mirsky Pais, Ana Carolina Alves de Mattos, Anna Christina de Matos Salim, Paulo Marcos Zech Coelho, Guilherme Correa Oliveira, John Robert Kusel, Renata Guerra-Sá, Roney Santos Coimbra, Élio Hideo Babá
Once inside a vertebrate host after infection, individual schistosomula of the parasite Schistosoma mansoni find a new and complex environment, which requires quick adjustments for survival, such as those that allow it to avoid the innate immune response of the host. Thus, it is very important for the parasite to remain within the skin after entering the host for a period of about 3 days, at which time it can then reach the venous system, migrate to the lungs and, by the end of eighth day post-infection, it reach the portal venous system, while undergoing minimal changes in morphology...
2017: PloS One
https://www.readbyqxmd.com/read/28621883/determination-of-the-serine-palmitoyl-transferase-inhibitor-myriocin-by-electrospray-and-q-trap-mass-spectrometry
#5
Giuseppe Matteo Campisi, Paola Signorelli, Jessica Rizzo, Claudio Ghilardi, Jacopo Antognetti, Anna Caretti, Jelena S Lazarevic, Enrica Strettoi, Elena Novelli, Riccardo Ghidoni, Federico Maria Rubino, Rita Paroni
Myriocin, is a potent inhibitor of serine-palmitoyl-transferase, the first and rate-determining enzyme in the sphingolipids biosynthetic pathway. This study developed, validated and applied a LC-MS/MS method to measure Myriocin in minute specimens of animal tissue. The chemical analog 14-OH-Myriocin is used as the internal standard. The two molecules are extracted from the tissue homogenate by solid-phase extraction, separated by gradient reverse-phase liquid chromatography and measured by negative ion electrospray mass spectrometry in the triple quadrupole...
June 16, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28620192/luminescent-turn-on-detection-of-hg-ii-via-the-quenching-of-an-iridium-iii-complex-by-hg-ii-mediated-silver-nanoparticles
#6
Jinshui Liu, Kasipandi Vellaisamy, Guanjun Yang, Chung-Hang Leung, Dik-Lung Ma
A novel luminescent turn-on detection method for Hg(II) was developed. The method was based on the silver nanoparticle (AgNP)-mediated quenching of Ir(III) complex 1. The addition of Hg(II) ions causes the luminescence of complex 1 to be recovered due to the oxidation of AgNPs by Hg(II) ions to form Ag(I) and Ag/Hg amalgam. The luminescence intensity of 1 increased in accord with an increased Hg(II) concentration ranging from 0 nM to 180 nM, with the detection limit of 5 nM. This approach offers an innovative method for the quantification of Hg(II)...
June 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28619955/pulmonary-artery-to-aorta-ratio-and-risk-of-all-cause-mortality-in-the-general-population-the-rotterdam-study
#7
Natalie Terzikhan, Daniel Bos, Lies Lahousse, Lennard Wolff, Katia M C Verhamme, Maarten J G Leening, Janine F Felix, Henning Gall, Hossein A Ghofrani, Oscar H Franco, M Arfan Ikram, Bruno H Stricker, Aad van der Lugt, Guy Brusselle
A pulmonary artery to aorta ratio (PA:A) >1 is a proxy of pulmonary hypertension. It is not known whether this measure carries prognostic information in the general population and in individuals with chronic obstructive pulmonary disease (COPD).Between 2003 and 2006, 2197 participants from the population-based Rotterdam Study (mean±sd age 69.7±6.7 years; 51.3% female), underwent cardiac computed tomography (CT) scanning with PA:A quantification, defined as the ratio between the diameters of the pulmonary artery and the aorta...
June 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28613103/quantification-of-igg-monoclonal-antibody-clearance-in-tissues
#8
Miro J Eigenmann, Ludivine Fronton, Hans Peter Grimm, Michael B Otteneder, Ben-Fillippo Krippendorff
Monoclonal antibodies are an important therapeutic entity, and knowledge of antibody pharmacokinetics has steadily increased over the years. Despite this effort, little is known about the extent of IgG antibody degradation in different tissues of the body. While studies have been published identifying sites of degradation with the use of residualizing and non-residualizing radiolabels, quantitative tissue clearances have not yet been derived. Here, we show that in physiologically-based pharmacokinetic (PBPK) models we can combine mouse data of Indium-111 and Iodine-125 labeled antibodies with prior physiological knowledge to determine tissue-specific intrinsic clearances...
June 14, 2017: MAbs
https://www.readbyqxmd.com/read/28612302/a-simplified-lung-ultrasound-approach-to-detect-increased-extravascular-lung-water-in-critically-ill-patients
#9
Antonio Anile, Jole Russo, Giacomo Castiglione, Giovanni Volpicelli
BACKGROUND: The quantification of B-lines at lung ultrasonography is a valid tool to estimate the extravascular lung water (EVLW) in patients after major cardiac surgery. However, there is still uncertainty about the correlation between B-lines and EVLW in a general population of critically ill. AIM: To evaluate a simplified lung ultrasonographic assessment as a tool to estimate the EVLW in critically ill patients admitted to a polyvalent intensive care unit (ICU)...
December 2017: Critical Ultrasound Journal
https://www.readbyqxmd.com/read/28599456/dynamic-monitoring-of-egfr-mutations-in-circulating-cell-free-dna-for-egfr-mutant-metastatic-patients-with-lung-cancer-early-detection-of-drug-resistance-and-prognostic-significance
#10
Jianjiao Ni, Linqian Weng, Yi Liu, Zhao Sun, Chunmei Bai, Yingyi Wang
Detecting genetic mutations in circulating cell-free DNA (cfDNA) is a promising approach of liquid biopsy. Between June 2014 and May 2015, 168 plasma samples were collected monthly from 20 patients with metastatic lung adenocarcinoma with epidermal growth factor receptor (EGFR) mutation receiving gefitinib therapy. Clinically relevant EGFR mutations, including exon 19 deletion, L858R and T790M, were quantified using droplet digital polymerase chain reaction. In baseline samples, 19 (95.0%) patients had the same mutation with the matched tumors, and pretreatment T790M mutations were also detected in 3 (15...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28599193/organic-and-inorganic-speciation-of-particulate-matter-formed-during-different-combustion-phases-in-an-improved-cookstove
#11
Anna Leavey, Sameer Patel, Raul Martinez, Dhruv Mitroo, Claire Fortenberry, Michael Walker, Brent Williams, Pratim Biswas
Residential solid fuel combustion in cookstoves has established health impacts including bladder and lung cancers, cataracts, low birth weight, and pneumonia. The chemical composition of particulate matter (PM) from 4 commonly-used solid fuels (coal, dung, ambient/dry applewood, and oakwood pellets), emitted from a gasifier cookstove, as well as propane, were examined. Temporal changes between the different cookstove burn-phases were also explored. Normalized concentrations of non-refractory PM1, total organics, chloride, ammonium, nitrate, sulfate, and 41 particle-phase polycyclic aromatic hydrocarbons (PAHs) were measured using a High-Resolution Time-of-Flight Aerosol Mass Spectrometer (HR-ToF-AMS) and a Thermal desorption Aerosol Gas chromatograph (TAG), respectively...
June 6, 2017: Environmental Research
https://www.readbyqxmd.com/read/28596268/application-of-euclidean-distance-mapping-for-assessment-of-basement-membrane-thickness-distribution-in-asthma
#12
Leila B Mostaco-Guidolin, Soheil M Hajimohammadi, Dragos Mihai Vasilescu, Tillie-Louise Hackett
Abnormal thickening of the airway basement membrane is one of the hallmarks of airway remodeling in asthma. Current protocols for measuring the basement membrane involve the use of stained tissue sections and measurements of the basement membrane thickness at certain intervals, followed by the calculation of the geometric mean thickness for each airway. This report describes an automated, unbiased approach which uses colour segmentation to identify structures of interest on stained sections and euclidean distance mapping to measure the thickness distribution of airway structures...
June 8, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28592874/ct-based-local-distribution-metric-improves-characterization-of-copd
#13
Benjamin A Hoff, Esther Pompe, Stefanie Galbán, Dirkje S Postma, Jan-Willem J Lammers, Nick H T Ten Hacken, Leo Koenderman, Timothy D Johnson, Stijn E Verleden, Pim A de Jong, Firdaus A A Mohamed Hoesein, Maarten van den Berge, Brian D Ross, Craig J Galbán
Parametric response mapping (PRM) of paired CT lung images has been shown to improve the phenotyping of COPD by allowing for the visualization and quantification of non-emphysematous air trapping component, referred to as functional small airways disease (fSAD). Although promising, large variability in the standard method for analyzing PRM(fSAD) has been observed. We postulate that representing the 3D PRM(fSAD) data as a single scalar quantity (relative volume of PRM(fSAD)) oversimplifies the original 3D data, limiting its potential to detect the subtle progression of COPD as well as varying subtypes...
June 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28588734/plasma-t790m-and-hgf-as-potential-predictive-markers-for-egfr-tki-re-challenge
#14
Tomomi Nakamura, Naomi Watanabe, Akemi Sato, Kazutoshi Komiya, Hitomi Umeguchi, Toshiya Hosomi, Mitsuharu Hirai, Eisaburo Sueoka, Shinya Kimura, Naoko Sueoka-Aragane
Re-challenge with epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI) has been suggested to potentially improve survival in certain populations of patients with advanced lung cancer, but predictive markers for the success of EGFR-TKI re-challenge have not been identified. The present study analyzed 16 re-challenges with EGFR-TKI undertaken in 12 patients with lung adenocarcinoma by investigating T790M and hepatocyte growth factor (HGF) in plasma coupled with clinical characteristics. EGFR mutations in plasma DNA were detected using the wild inhibiting PCR and quenched probe system for exon 19 deletions, and T790M and L858R were detected using the mutation-biased PCR and quenched probe system...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28587590/rna-sequencing-and-transcriptome-arrays-analyses-show-opposing-results-for-alternative-splicing-in-patient-derived-samples
#15
Petr V Nazarov, Arnaud Muller, Tony Kaoma, Nathalie Nicot, Cristina Maximo, Philippe Birembaut, Nhan L Tran, Gunnar Dittmar, Laurent Vallar
BACKGROUND: RNA sequencing (RNA-seq) and microarrays are two transcriptomics techniques aimed at the quantification of transcribed genes and their isoforms. Here we compare the latest Affymetrix HTA 2.0 microarray with Illumina 2000 RNA-seq for the analysis of patient samples - normal lung epithelium tissue and squamous cell carcinoma lung tumours. Protein coding mRNAs and long non-coding RNAs (lncRNAs) were included in the study. RESULTS: Both platforms performed equally well for protein-coding RNAs, however the stochastic variability was higher for the sequencing data than for microarrays...
June 6, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28578903/intrinsic-capabilities-of-leptospermum-javanicum-in-inducing-apoptosis-and-suppressing-the-metastatic-potential-of-human-lung-carcinoma-cells
#16
Suerialoasan Navanesan, Norhanom Abdul Wahab, Sugumaran Manickam, Yuen Lin Cheow, Kae Shin Sim
The active isolate of LF1 in Leptospermum javanicum was further looked into its capabilities in provoking an apoptotic reaction and suppressing the metastasis process in treated non-small lung cancer cells. LF1 underwent isolation and purification to yield a white powder which was identified as Betulinic acid (BA) via NMR, LCMS and IR spectroscopy. The isolate, BA, which produced an encouraging cytotoxic effect against non-small lung cancer cells (A549 and NCI-H1299) through the MTT assay, was further assessed with TUNEL, Sub-G1 population quantification, acridine orange/ethidium bromide staining as well as activated caspase-3 detection...
June 2, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28578255/development-and-validation-of-an-ultra-performance-liquid-chromatography-tandem-mass-spectrometry-method-for-quantification-of-sr1001-an-inverse-agonist-of-retinoid-related-orphan-receptors-and-its-application-to-pharmacokinetic-studies-in-streptozotocin-induced
#17
Cuipei Lin, Hanqing Wang, Hua Sun, Chengju Xiao, Yunxia Xue, Jun Liu, Ting Fu, Yifei Wang, Dong Dong, Zhijie Li
Retinoic acid receptor-related orphan receptors (RORs) play critical roles in the onset and progression of type I diabetes, an autoimmune disease characterized by the destruction of pancreatic β-cells. SR1001, an ROR inverse agonist, has been proven to be an effective diabetes treatment in the non-obese diabetic (NOD) mouse model. However, optimization of this treatment is challenging because knowledge of SR1001 pharmacokinetic (PK) behaviors in type I diabetic animals is limited. The aim of our study was to develop and validate a specific and sensitive ultra-performance liquid chromatography-tandem mass spectrometric (UPLC-MS/MS) method to measure the concentrations of SR1001 in plasma and biological samples...
May 24, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28574715/development-of-a-data-independent-targeted-metabolomics-method-for-relative-quantification-using-liquid-chromatography-coupled-with-tandem-mass-spectrometry
#18
Yanhua Chen, Zhi Zhou, Wei Yang, Nan Bi, Jing Xu, Jiuming He, Ruiping Zhang, Lvhua Wang, Zeper Abliz
Quantitative metabolomics approaches can significantly improve the repeatability and reliability of metabolomics investigations but face critical technical challenges, owing to the vast number of unknown endogenous metabolites and the lack of authentic standards. The present study contributes to the development of a novel method known as "data-independent targeted quantitative metabolomics" (DITQM), which was used to investigate the label-free quantitative metabolomics of multiple known and unknown metabolites in biofluid samples...
June 15, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28573855/nucleic-acid-amplification-free-bioluminescent-detection-of-micrornas-with-high-sensitivity-and-accuracy-based-on-controlled-target-degradation
#19
Qinfeng Xu, Fei Ma, Si-Qiang Huang, Bo Tang, Chun-Yang Zhang
Accurate and sensitive detection of microRNAs is crucial to clinical diagnosis and therapy. Most of microRNA assays require target conversion in combination with nucleic acid amplification to improve the detection sensitivity, which may compromise the assay accuracy and specificity. Herein we report a sensitive bioluminescent method for microRNA assay on the basis of controlled target degradation without target conversion and nucleic acid amplification. In this assay, the target microRNA can be specifically degraded by exonuclease III after hybridization to its complementary probe, releasing adenosine monophosphate (AMP) from microRNA itself...
June 14, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28572289/parametric-method-performance-for-dynamic-3-deoxy-3-18-f-fluorothymidine-pet-ct-in-epidermal-growth-factor-receptor-mutated-non-small-cell-lung-carcinoma-patients-before-and-during-therapy
#20
Gerbrand Maria Kramer, Virginie Frings, Dennis Heijtel, E F Smit, Otto S Hoekstra, Ronald Boellaard
The objective of this study was to validate several parametric methods for quantification of 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT) PET in advanced-stage non-small cell lung carcinoma (NSCLC) patients with an activating epidermal growth factor receptor mutation who were treated with gefitinib or erlotinib. Furthermore, we evaluated the impact of noise on accuracy and precision of the parametric analyses of dynamic (18)F-FLT PET/CT to assess the robustness of these methods. Methods: Ten NSCLC patients underwent dynamic (18)F-FLT PET/CT at baseline and 7 and 28 d after the start of treatment...
June 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
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