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https://www.readbyqxmd.com/read/27486567/neuroendocrine-tumors-of-the-large-intestine-clinicopathological-features-and-predictive-factors-of-lymph-node-metastasis
#1
Motohiro Kojima, Koji Ikeda, Norio Saito, Naoki Sakuyama, Kenichi Koushi, Shingo Kawano, Toshiaki Watanabe, Kenichi Sugihara, Masaaki Ito, Atsushi Ochiai
A new histological classification of neuroendocrine tumors (NETs) was established in WHO 2010. ENET and NCCN proposed treatment algorithms for colorectal NET. Retrospective study of NET of the large intestine (colorectal and appendiceal NET) was performed among institutions allied with the Japanese Society for Cancer of the Colon and Rectum, and 760 neuroendocrine tumors from 2001 to 2011 were re-assessed using WHO 2010 criteria to elucidate the clinicopathological features of NET in the large intestine. Next, the clinicopathological relationship with lymph node metastasis was analyzed to predict lymph node metastasis in locally resected rectal NET...
2016: Frontiers in Oncology
https://www.readbyqxmd.com/read/26730583/enets-consensus-guidelines-for-neuroendocrine-neoplasms-of-the-appendix-excluding-goblet-cell-carcinomas
#2
U-F Pape, B Niederle, F Costa, D Gross, F Kelestimur, R Kianmanesh, U Knigge, K Öberg, M Pavel, A Perren, C Toumpanakis, J O'Connor, E Krenning, N Reed, D O'Toole
No abstract text is available yet for this article.
2016: Neuroendocrinology
https://www.readbyqxmd.com/read/26356507/appendiceal-goblet-cell-carcinoids-management-considerations-from-a-reference-peritoneal-tumour-service-centre-and-enets-centre-of-excellence
#3
Angela Lamarca, Daisuke Nonaka, Cristina Lopez Escola, Richard A Hubner, Sarah O'Dwyer, Bipasha Chakrabarty, Paul Fulford, Juan W Valle
BACKGROUND: Appendix goblet cell carcinoids are known to share histological features of adenocarcinoma and neuroendocrine tumours. Due to their low incidence, quality evidence is lacking for the management of these patients. METHODS: We performed a single-centre retrospective study of patients with a confirmed diagnosis of appendiceal goblet cell carcinoid (GCC; 1996-2014). Patients were divided into curative intent (CI) and palliative intent (PI) cohorts. Our primary end point was overall survival (OS)...
2016: Neuroendocrinology
https://www.readbyqxmd.com/read/26123382/everolimus-and-pancreatic-neuroendocrine-tumors-pnets-activity-resistance-and-how-to-overcome-it
#4
REVIEW
Monica Capozzi, Ieranò Caterina, Chiara De Divitiis, Claudia von Arx, Piera Maiolino, Fabiana Tatangelo, Ernesta Cavalcanti, Elena Di Girolamo, Rosario Vincenzo Iaffaioli, Stefania Scala, Salvatore Tafuto
Neuroendocrine tumors (NET) are rare malignancies, with the most common site of origin being from the gastrointestinal tract, particularly the pancreas, small bowel and appendix. Pancreatic neuroendocrine tumors (PNETs) can be functional, hormone secreting tumors, and can have distinctive symptoms leading to the diagnosis. In contrast nonfunctional tumors, the majority of PNETs, usually present later either incidentally or due to tumor bulk symptoms. Currently Everolimus, an inhibitor of mammalian target of rapamycin (mTOR), is the most promising drug for patients with unresectable, metastatic disease, in progressive well-differentiated PNETs and many studies are ongoing to demonstrate its effects on the other neuroendocrine histotipes...
September 2015: International Journal of Surgery
https://www.readbyqxmd.com/read/24554450/diagnosis-and-workup-of-522-consecutive-patients-with-neuroendocrine-neoplasms-in-switzerland
#5
Marine Gouffon, Samuel Iff, Katrin Ziegler, Maria Larche, Christiane Schwarzenbach, John O Prior, Maurice Matter, Christoph Stettler, François P Pralong
BACKGROUND: Neuroendocrine neoplasms (NENs) are difficult to diagnose. We used SwissNET data to characterise NEN patients followed in the two academic centres of western Switzerland (WS), and to compare them with patients followed in eastern Switzerland (ES) as well as with international guidelines. METHOD: SwissNET is a prospective database covering data from 522 consecutive patients (285 men, 237 women) from WS (n = 99) and ES (n = 423). RESULTS: Mean ± SD age at diagnosis was 59...
February 19, 2014: Swiss Medical Weekly
https://www.readbyqxmd.com/read/22262080/enets-consensus-guidelines-for-the-management-of-patients-with-neuroendocrine-neoplasms-from-the-jejuno-ileum-and-the-appendix-including-goblet-cell-carcinomas
#6
Ulrich-Frank Pape, Aurel Perren, Bruno Niederle, David Gross, Thomas Gress, Frederico Costa, Rudolf Arnold, Timm Denecke, Ursula Plöckinger, Ramon Salazar, Ashley Grossman
No abstract text is available yet for this article.
2012: Neuroendocrinology
https://www.readbyqxmd.com/read/20935447/clinical-value-of-right-hemicolectomy-for-appendiceal-carcinoids-using-pathologic-criteria
#7
K I Alexandraki, J Griniatsos, K I Bramis, N Ballian, N Dimitriou, T Giannakakis, C Tsigris, E Felekouras, G A Kaltsas
BACKGROUND: Appendiceal carcinoids (AC) are usually adequately treated by appendectomy. The European Neuroendocrine Tumours Society (ENETS) has recently reconsidered the previous pathologic criteria to identify patients at high risk of extra-appendiceal disease, who are thought to require right hemicolectomy (RHC). AIM: The aim of this retrospective, observational study was to evaluate previous and currently introduced criteria, in identifying patients with AC in whom RHC is justified...
April 2011: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/20702725/gastroenteropancreatic-neuroendocrine-tumours-the-current-incidence-and-staging-based-on-the-who-and-european-neuroendocrine-tumour-society-classification-an-analysis-based-on-prospectively-collected-parameters
#8
Martin B Niederle, Monika Hackl, Klaus Kaserer, Bruno Niederle
As incidence data on gastroenteropancreatic neuroendocrine tumours (GEP-NETs) have so far only been retrospectively obtained and based on inhomogeneous material, we conducted a prospective study in Austria collecting all newly diagnosed GEP-NETs during 1 year. Using the current WHO classification, the tumor, nodes, metastases (TNM) staging and Ki67 grading and the standard diagnostic procedure proposed by the European Neuroendocrine Tumor Society (ENETS), GEP-NETs from 285 patients (male: 148; female: 137) were recorded...
December 2010: Endocrine-related Cancer
https://www.readbyqxmd.com/read/17674042/tnm-staging-of-midgut-and-hindgut-neuro-endocrine-tumors-a-consensus-proposal-including-a-grading-system
#9
G Rindi, G Klöppel, A Couvelard, P Komminoth, M Körner, J M Lopes, A-M McNicol, O Nilsson, A Perren, A Scarpa, J-Y Scoazec, B Wiedenmann
Criteria for the staging and grading of neuroendocrine tumors (NETs) of midgut and hindgut origin were established at the second Consensus Conference in Frascati (Rome) organized by the European Neuroendocrine Tumor Society (ENETS). The proposed tumor-node-metastasis (TNM) classifications are based on the recently published ENETS Guidelines for the Diagnosis and Treatment of gastroenteropancreatic NETs and follow our previous proposal for foregut tumors. The new TNM classifications for NETs of the ileum, appendix, colon, and rectum, and the grading system were designed, discussed, and consensually approved by all conference participants...
October 2007: Virchows Archiv: An International Journal of Pathology
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