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https://www.readbyqxmd.com/read/28527406/the-relevance-of-ki-calculation-for-bi-substrate-enzymes-illustrated-by-kinetic-evaluation-of-a-novel-lysine-k-acetyltransferase-8-inhibitor
#1
Hannah Wapenaar, Thea van den Bosch, Niek G J Leus, Petra E van der Wouden, Nikolaos Eleftheriadis, Jos Hermans, Gebremedhin Solomon Hailu, Dante Rotili, Antonello Mai, Alexander Dömling, Rainer Bischoff, Hidde J Haisma, Frank J Dekker
Histone acetyltransferases (HATs) are important mediators of epigenetic post-translational modifications of histones that play important roles in health and disease. A disturbance of these modifications can result in disease states, such as cancer or inflammatory diseases. Inhibitors of HATs (HATi) such as lysine (K) acetyltransferase 8 (KAT8), could be used to study the epigenetic processes in diseases related to these enzymes or to investigate HATs as therapeutic targets. However, the development of HATi is challenged by the difficulties in kinetic characterization of HAT enzymes and their inhibitors to enable calculation of a reproducible inhibitory potency...
May 5, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28527285/-genetic-diversity-of-extraintestinal-escherichia-coli-strains-producers-of-beta-lactamases-tem-shv-and-ctx-m-associated-with-healthcare
#2
Yasmin Varela, Beatriz Millán, María Araque
INTRODUCTION: There are few reports from Venezuela describing the genetic basis that sustains the pathogenic potential and phylogenetics of Escherichia coli extraintestinal strains isolated in health care units. OBJECTIVE: To establish the genetic diversity of extraintestinal E. coli strains producers of betalactamases TEM, SHV and CTX-M associated with healthcare. MATERIALS AND METHODS: We studied a collection of 12 strains of extraintestinal E...
June 1, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/28527271/self-rated-health-multimorbidity-and-depression-in-mexican-older-adults-proposal-and-evaluation-of-a-simple-conceptual-model
#3
Eduardo Bustos-Vázquez, Julián Alfredo Fernández-Niño, Claudia Iveth Astudillo-Garcia
INTRODUCTION: Self-rated health is an individual and subjective conceptualization involving the intersection of biological, social and psychological factors. It provides an invaluable and unique evaluation of a person's general health status. OBJECTIVE: To propose and evaluate a simple conceptual model to understand self-rated health and its relationship to multimorbidity, disability and depressive symptoms in Mexican older adults. MATERIALS AND METHODS: We conducted a cross-sectional study based on a national representative sample of 8,874 adults of 60 years of age and older...
April 1, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/28527216/effects-of-healthy-aging-and-mild-cognitive-impairment-on-a-real-life-decision-making-task
#4
Marie-Theres Pertl, Thomas Benke, Laura Zamarian, Margarete Delazer
In this study, we investigated the effects of age and of mild cognitive impairment (MCI) on decision making under risk by adopting a task representing real-life health-related situations and involving complex numerical information. Moreover, we assessed the relationship of real-life decision making to other cognitive functions such as number processing, executive functions, language, memory, and attention. For this reason, we compared the performance of 19 healthy, relatively younger adults with that of 18 healthy older adults as well as the performance of the 18 healthy older adults with that of 17 patients with MCI...
May 17, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28527183/analytical-methods-in-tracing-honey-authenticity
#5
Jelena Trifković, Filip Andrić, Petar Ristivojević, Etil Guzelmeric, Erdem Yesilada
Honey is a precious natural product that is marketed with a wide range of nutritional and medicinal properties. However, it is also a product subjected to frequent adulteration through mislabeling and mixing with cheaper and lower-quality honeys and various sugar syrups. In that sense, honey authentication regarding its genuine botanical and geographical origins, as well as the detection of any adulteration, is essential in order to protect consumer health and to avoid competition that could create a destabilized market...
May 19, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28527007/factors-associated-with-supportive-care-needs-in-glioma-patients-in-the-neuro-oncological-outpatient-setting
#6
Mirjam Renovanz, Marlene Hechtner, Mareile Janko, Karoline Kohlmann, Jan Coburger, Minou Nadji-Ohl, Jochem König, Florian Ringel, Susanne Singer, Anne-Katrin Hickmann
Objective of this study aimed at assessing glioma patients' supportive care needs in a neurosurgical outpatient setting and identifying factors that are associated with needs for support. In three neuro-oncological outpatient departments, glioma patients were assessed for their psychosocial needs using the Supportive Care Needs Survey short-form (SCNS-SF34-G). Associations between clinical, sociodemographic, treatment related factors as well as distress (measured with the distress thermometer) and supportive care needs were explored using multivariable general linear models...
May 19, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28526974/the-health-equity-scholars-program-innovation-in-the-leaky-pipeline
#7
Carole C Upshur, Diedra M Wrighting, Gonzalo Bacigalupe, Joan Becker, Laura Hayman, Barbara Lewis, Sylvia Mignon, Megan E Rokop, Elizabeth Sweet, Marie Idali Torres, Paul Watanabe, Cedric Woods
Despite attempts to increase enrollment of under-represented minorities (URMs: primarily Black/African American, Hispanic/Latino, and Native American students) in health professional programs, limited progress has been made. Compelling reasons to rectify this situation include equity for URMs, better prepared health professionals when programs are diverse, better quality and access to health care for UMR populations, and the need for diverse talent to tackle difficult questions in health science and health care delivery...
May 19, 2017: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/28526852/health-benefit-of-vegetable-fruit-juice-based-diet-role-of-microbiome
#8
Susanne M Henning, Jieping Yang, Paul Shao, Ru-Po Lee, Jianjun Huang, Austin Ly, Mark Hsu, Qing-Yi Lu, Gail Thames, David Heber, Zhaoping Li
The gut microbiota is an important contributor to human health. Vegetable/fruit juices provide polyphenols, oligosaccharides, fiber and nitrate (beet juice), which may induce a prebiotic-like effect. Juice-based diets are becoming popular. However, there is a lack of scientific evidence of their health benefits. It was our hypothesis that changes in the intestinal microbiota induced by a juice-based diet play an important role in their health benefits. Twenty healthy adults consumed only vegetable/fruit juices for 3 days followed by 14 days of customary diet...
May 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28526792/environmental-spread-of-ndm-1-producing-multi-drug-resistant-bacteria-in-dhaka-bangladesh
#9
Mohammad Aminul Islam, Moydul Islam, Rashedul Hasan, M Iqbal Hossain, Ashikun Nabi, Mahdia Rahman, Wil H F Goessens, Hubert P Endtz, Alexandria B Boehm, Shah M Faruque
Resistance to carbapenem antibiotics through the production of New Delhi Metallo-β-lactamase-1 (NDM-1) constitutes an emerging challenge in the treatment of bacterial infections. To monitor possible source of spread of these organisms in Dhaka, Bangladesh, we conducted comparative analysis of waste water samples from hospital adjacent areas (HAR) and from community areas (COM) as well as public tap water samples for the occurrence and characteristics of NDM-1 producing bacteria. Of 72 HAR samples tested 51 (71%) were positive for NDM-1-producing bacteria as evidenced by phenotypic tests and the presence of blaNDM-1 gene, compared to 5 of 41 (12...
May 19, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28526704/elder-women-s-perceptions-around-optimal-perinatal-health-a-constructivist-grounded-theory-study-with-an-indigenous-community-in-southern-ontario
#10
Sujane Kandasamy, Meredith Vanstone, Mark Oremus, Trista Hill, Gita Wahi, Julie Wilson, A Darlene Davis, Ruby Jacobs, Rebecca Anglin, Sonia Savitri Anand
BACKGROUND: Women play important roles in translating health knowledge, particularly around pregnancy and birth, in Indigenous societies. We investigated elder Indigenous women's perceptions around optimal perinatal health. METHODS: Using a methodological framework that integrated a constructivist grounded-theory approach with an Indigenous epistemology, we conducted and analyzed in-depth interviews and focus groups with women from the Six Nations community in southern Ontario who self-identified as grandmothers...
May 18, 2017: CMAJ Open
https://www.readbyqxmd.com/read/28526672/a-systematic-review-and-meta-analysis-of-e-mental-health-interventions-to-treat-symptoms-of-posttraumatic-stress
#11
Sara Simblett, Jennifer Birch, Faith Matcham, Lidia Yaguez, Robin Morris
BACKGROUND: Posttraumatic stress disorder (PTSD) is a stress disorder characterized by unwanted intrusive re-experiencing of an acutely distressing, often life-threatening, event, combined with symptoms of hyperarousal, avoidance, as well as negative thoughts and feelings. Evidence-based psychological interventions have been developed to treat these symptoms and reduce distress, the majority of which were designed to be delivered face-to-face with trained therapists. However, new developments in the use of technology to supplement and extend health care have led to the creation of e-Mental Health interventions...
May 17, 2017: JMIR Mental Health
https://www.readbyqxmd.com/read/28526635/arsenic-exposures-alter-clinical-indicators-of-anemia-in-a-male-population-of-smokers-and-non-smokers-in-bangladesh
#12
Faruque Parvez, Sebastian Medina, Regina Santella, Tariqul Islam, Fredine T Lauer, Nur Alam, Mahbubul Eunus, Mizanour Rahman, Pam Factor-Litvak, Habib Ahsan, Joseph Graziano, Ke Jian Liu, Scott W Burchiel
Drinking water arsenic (WAs) exposure has been linked to a number of detrimental health outcomes including anemia, primarily among pregnant women. Little is known about the effects of arsenic (As) on hematological disorders among men. We have examined the role of As exposure on hematological indicators of anemia in a group of men exposed to a wide range of As in their drinking water. We conducted a cross-sectional investigation among 119 healthy men in the Health Effects of As Longitudinal Study (HEALS) cohort, in rural Bangladesh...
May 16, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28526620/evidence-for-cortical-structural-plasticity-in-humans-after-a-day-of-waking-and-sleep-deprivation
#13
Torbjørn Elvsåshagen, Nathalia Zak, Linn B Norbom, Per Ø Pedersen, Sophia H Quraishi, Atle Bjørnerud, Dag Alnæs, Nhat Trung Doan, Ulrik F Malt, Inge R Groote, Lars T Westlye
Sleep is an evolutionarily conserved process required for human health and functioning. Insufficient sleep causes impairments across cognitive domains, and sleep deprivation can have rapid antidepressive effects in mood disorders. However, the neurobiological effects of waking and sleep are not well understood. Recently, animal studies indicated that waking and sleep are associated with substantial cortical structural plasticity. Here, we hypothesized that structural plasticity can be observed after a day of waking and sleep deprivation in the human cerebral cortex...
May 16, 2017: NeuroImage
https://www.readbyqxmd.com/read/28526582/mait-cells-a-tailor-made-mate-in-the-ancient-battle-against-infectious-diseases
#14
REVIEW
Marcela de Lima Moreira, Moriya Tsuji, Alexandra Jane Corbett, Márcio Sobreira Silva Araújo, Andréa Teixeira-Carvalho, Olindo Assis Martins-Filho, Vanessa Peruhype-Magalhães, Jordana Grazziela Coelho-Dos-Reis
It has been almost two decades since the discovery of mucosal-associated invariant T (MAIT)-cells. Several advances in the field have been made such as the discovery of the antimicrobial activity of MAIT-cells, the abundance of these cells in human mucosa and in liver and the discovery of ligands able to bind MR1 and activate MAIT-cells. MAIT-cells are a unique subset of innate-like T-cells that express a canonical T-cell receptor with the alpha chain containing hAV7S2 and AJ33 in humans (TCRVα7.2Jα33) and respond to bacterial/fungus vitamin B2 metabolites by an MR1-dependent pathway...
May 16, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28526570/role-of-medicinal-plants-on-growth-performance-and-immune-status-in-fish
#15
REVIEW
Elham Awad, Amani Awaad
Disease outbreaks increase proportionally with increases in intensive aquaculture. Natural products including medicinal plants have been known from thousands of years for treating some human diseases. It is well known that many active compounds are responsible for potential bio-activities. For that reason, there has been considerable interest in the use of medicinal plants in aquaculture with a view to providing safe and eco-friendly compounds for replacing antibiotics and chemical compounds as well as to enhance immune status and control fish diseases...
May 16, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28526532/significant-elevation-of-serum-caspase-3-levels-in-patients-with-intracerebral-hemorrhage
#16
De-Biao Sun, Meng-Jun Xu, Qing-Meng Chen, Hai-Tao Hu
BACKGROUND: Caspase-3 is a potential marker of apoptosis. We investigated whether serum caspase-3 concentrations were increased and its association with severity and prognosis after intracerebral hemorrhage (ICH). METHODS: This prospective clinical study recruited 112 ICH patients and 112 healthy individuals. Serum was assayed for caspase-3 using enzyme-linked immunosorbent assay. Stroke severity was quantified by National Institute of Health Stroke Scale (NIHSS) and hematoma volume...
May 16, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28526485/improving-the-sexual-health-of-young-people-with-mobility-impairments-challenges-and-recommendations
#17
Molly Secor-Turner, Barbara J McMorris, Peter Scal
INTRODUCTION: This mixed-method study (a) describes challenges to providing sexual health services to youth with mobility impairments from the perspective of health care providers and experts and (b) describes and compares sexual health-related experiences of youth with mobility impairments. METHOD: Secondary data analysis of My Path, a study focused on the transition to adulthood for youth with mobility impairments. Using an exploratory sequential design, qualitative data (n = 10) were analyzed using systematic content analysis followed by quantitative analysis of survey data (N = 337)...
May 16, 2017: Journal of Pediatric Health Care
https://www.readbyqxmd.com/read/28526435/the-bidirectional-gut-brain-microbiota-axis-as-a-potential-nexus-between-traumatic-brain-injury-inflammation-and-disease
#18
Mark H Sundman, Nan-Kuei Chen, Vignesh Subbian, Ying-Hui Chou
As head injuries and their sequelae have become an increasingly salient matter of public health, experts in the field have made great progress elucidating the biological processes occurring within the brain at the moment of injury and throughout the recovery thereafter. Given the extraordinary rate at which our collective knowledge of neurotrauma has grown, new insights may be revealed by examining the existing literature across disciplines with a new perspective. This article will aim to expand the scope of this rapidly evolving field of research beyond the confines of the central nervous system (CNS)...
May 16, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28526428/extensively-drug-resistant-bacteria-which-ethical-issues
#19
P Vassal, P Berthelot, J P Chaussinand, S Jay, J P de Filippis, C Auboyer, F Renoux, D Bedoin
OBJECTIVE: The increased bacterial resistance to antibiotics has now become a public health concern. How can we preserve the well-being of patients presenting with infections caused by extensively drug-resistant bacteria (EDRBs) and that of their contacts without inducing any loss of chance of survival, all the while living together and controlling the spread of these EDRBs? METHOD: Terre d'éthique, a French territorial ethics committee, was asked to reflect on this topic by the infection control unit of a French University Hospital as it raises many ethical issues...
May 16, 2017: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/28526394/do-high-participation-rates-improve-effects-of-population-based-general-health-checks
#20
A M Bender, T Jørgensen, C Pisinger
The aim is to investigate if the effect of a health check differs between areas with different participation rates. The Inter99 population-based randomized lifestyle intervention study covered 73 areas within the suburbs of Copenhagen, Denmark. Adults aged 30-60years were randomly drawn from a population and were randomized to intervention group (n=11,483) or control group (n=47,122). Participation rates in the health check varied considerably between areas (mean 52%; range 35-85%). In separate survival analyses, area participation rate was included both as a continuous exposure variable and as a categorical variable (tertiles; low: 35-49%, meddle: 50-54%, high: 55-84%)...
May 16, 2017: Preventive Medicine
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