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https://www.readbyqxmd.com/read/28651376/comparison-of-sampling-strategies-for-tobacco-retailer-inspections-to-maximize-coverage-in-vulnerable-areas-and-minimize-cost
#1
Joseph G L Lee, Bonnie E Shook-Sa, J Michael Bowling, Kurt M Ribisl
Introduction: In the United States, tens of thousands of inspections of tobacco retailers are conducted each year. Various sampling choices can reduce travel costs, emphasize enforcement in areas with greater non-compliance, and allow for comparability between states and over time. We sought to develop a model sampling strategy for state tobacco retailer inspections. Methods: Using a 2014 list of 10,161 North Carolina tobacco retailers, we compared results from simple random sampling; stratified, clustered at the ZIP code sampling; and, stratified, clustered at the census tract sampling...
June 23, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28651363/multimodal-mechanistic-signatures-for-neurodegenerative-diseases-neurommsig-a-web-server-for-mechanism-enrichment
#2
Daniel Domingo-Fernández, Alpha Tom Kodamullil, Anandhi Iyappan, Mufassra Naz, Mohammad Asif Emon, Tamara Raschka, Reagon Karki, Stephan Springstubbe, Christian Ebeling, Martin Hofmann-Apitius
Motivation: The concept of a "mechanism-based taxonomy of human disease" is currently replacing the outdated paradigm of diseases classified by clinical appearance. We have tackled the paradigm of mechanism-based patient subgroup identification in the challenging area of research on neurodegenerative diseases. Results: We have developed a knowledge base representing essential pathophysiology mechanisms of neurodegenerative diseases. Together with dedicated algorithms, this knowledge base forms the basis for a "mechanism-enrichment server" that supports the mechanistic interpretation of multiscale, multimodal clinical data...
June 23, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28651345/prioritizing-quality-measure-concepts-at-the-interface-of-behavioral-and-physical-healthcare
#3
Harold Alan Pincus, Mingjie Li, Deborah M Scharf, Brigitta Spaeth-Rublee, Matthew L Goldman, Parashar P Ramanuj, Erin K Ferenchick
Objective: Integrated healthcare models can increase access to care, improve healthcare quality, and reduce cost for individuals with behavioral and general medical healthcare needs, yet there are few instruments for measuring the quality of integrated care. In this study, we identified and prioritized concepts that can represent the quality of integrated behavioral health and general medical care. Design: We conducted a literature review to identify candidate measure concepts...
June 23, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/28651340/linking-quality-indicators-to-clinical-trials-an-automated-approach
#4
Enrico Coiera, Miew Keen Choong, Guy Tsafnat, Peter Hibbert, William B Runciman
Objective: Quality improvement of health care requires robust measurable indicators to track performance. However identifying which indicators are supported by strong clinical evidence, typically from clinical trials, is often laborious. This study tests a novel method for automatically linking indicators to clinical trial registrations. Design: A set of 522 quality of care indicators for 22 common conditions drawn from the CareTrack study were automatically mapped to outcome measures reported in 13 971 trials from ClinicalTrials...
June 23, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/28651325/design-of-marine-macroalgae-photobioreactor-integrated-into-building-to-support-seagriculture-for-biorefinery-and-bioeconomy
#5
Alexander Chemodanov, Arthur Robin, Alexander Golberg
Seagriculture, which can provide offshore grown macroalgae biomass would play a significant role in bioeconomy. Nevertheless, seagriculture development has been hindered by the lack of laboratory photobioreactors that enable fundamental and pilot scale macroalgae research. In this work, a macroalgae photobioreactor (MPBR) was developed and integrated into the building. The MPBR operation was demonstrated for 6months with cultivation of Cladophora sp., Ulva compressa and Ulva rigida green macroalgae species isolated from 3 sites at the Eastern Mediterranean coast...
June 13, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28651318/fate-of-polycyclic-aromatic-hydrocarbons-from-the-north-pacific-to-the-arctic-field-measurements-and-fugacity-model-simulation
#6
Hongwei Ke, Mian Chen, Mengyang Liu, Meng Chen, Mengshan Duan, Peng Huang, Jiajun Hong, Yan Lin, Shayen Cheng, Xuran Wang, Mengxue Huang, Minggang Cai
Polycyclic aromatic hydrocarbons (PAHs) have accumulated ubiquitously inArctic environments, where re-volatilization of certain organic pollutants as a result of climate change has been observed. To investigate the fate of semivolatile organic compounds in the Arctic, dissolved PAHs in the surface seawaters from the temperate Pacific Ocean to the Arctic Ocean, as well as a water column in the Arctic Ocean, were collected during the 4th Chinese National Arctic Research Expedition in summer 2010. The total concentrations of seven dissolved PAHs in surface water ranged from 1...
June 16, 2017: Chemosphere
https://www.readbyqxmd.com/read/28651254/a-preliminary-study-of-a-spanish-graphic-novella-targeting-hearing-loss-prevention
#7
Mark Guiberson, Emily Wakefield
Purpose: This preliminary study developed a digital graphic novella targeting hearing protection beliefs of Spanish-speaking agricultural workers. Researchers used pretest-posttest interview surveys to establish if the novella had an immediate influence on the participants' beliefs about noise-induced hearing loss and usage of hearing protection devices. Method: Researchers developed a digital graphic novella directed to increase knowledge about noise-induced hearing loss and increase the proper use of hearing protection devices...
June 23, 2017: American Journal of Audiology
https://www.readbyqxmd.com/read/28651252/combined-diffusion-tensor-and-magnetic-resonance-spectroscopic-imaging-methodology-for-automated-regional-brain-analysis-application-in-a-normal-pediatric-population
#8
Nirmalya Ghosh, Barbara Holshouser, Udo Oyoyo, Stanley Barnes, Karen Tong, Stephen Ashwal
During human brain development, anatomic regions mature at different rates. Quantitative anatomy-specific analysis of longitudinal diffusion tensor imaging (DTI) and magnetic resonance spectroscopic imaging (MRSI) data may improve our ability to quantify and categorize these maturational changes. Computational tools designed to quickly fuse and analyze imaging information from multiple, technically different datasets would facilitate research on changes during normal brain maturation and for comparison to disease states...
June 27, 2017: Developmental Neuroscience
https://www.readbyqxmd.com/read/28651188/hyperhomocysteinaemia-is-an-independent-risk-factor-for-peripheral-arterial-disease-in-a-chinese-han-population
#9
Dan Rong, Jie Liu, Xin Jia, Daniah Al-Nafisee, Senhao Jia, Guoyi Sun, Yue Li, Weihang Lu, Haifeng Li, Hongpeng Zhang, Xiaohui Ma, Jiang Xiong, Xiaoping Liu, Raouf A Khalil, Wei Guo
BACKGROUND AND AIMS: Hyperhomocysteineamia (HHcy) has long been suggested as a risk factor for atherosclerosis. However, the association between HHcy and peripheral arterial disease (PAD) is still controversial. There is a lack of research on this topic in the Chinese population. This study aims to provide further results. METHODS: 240 PAD patients and 240 control subjects were evaluated for both serum total homocysteine levels and ankle brachial indexes (ABIs)...
May 5, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28651144/improved-anticancer-effects-of-albumin-bound-paclitaxel-nanoparticle-via-augmentation-of-epr-effect-and-albumin-protein-interactions-using-s-nitrosated-human-serum-albumin-dimer
#10
Ryo Kinoshita, Yu Ishima, Victor T G Chuang, Hideaki Nakamura, Jun Fang, Hiroshi Watanabe, Taro Shimizu, Keiichiro Okuhira, Tatsuhiro Ishida, Hiroshi Maeda, Masaki Otagiri, Toru Maruyama
In the latest trend of anticancer chemotherapy research, there were many macromolecular anticancer drugs developed based on enhanced permeability and retention (EPR) effect, such as albumin bound paclitaxel nanoparticle (nab- PTX, also called Abraxane(®)). However, cancers with low vascular permeability posed a challenge for these EPR based therapeutic systems. Augmenting the intrinsic EPR effect with an intrinsic vascular modulator such as nitric oxide (NO) could be a promising strategy. S-nitrosated human serum albumin dimer (SNO-HSA Dimer) shown promising activity previously was evaluated for the synergistic effect when used as a pretreatment agent in nab-PTX therapy against various tumor models...
June 22, 2017: Biomaterials
https://www.readbyqxmd.com/read/28651135/a-model-biorefinery-for-avocado-persea-americana-mill-processing
#11
Javier A Dávila, Moshe Rosenberg, Eulogio Castro, Carlos A Cardona
This research investigated and evaluated a biorefinery for processing avocado Hass variety into microencapsulated phenolic compounds extract, ethanol, oil and xylitol. Avocado was first characterized for its potential valuable compounds; then, the techno-economic and environmental aspects of the biorefinery were developed and finally the total production costs and potential environmental impact of the proposed biorefinery were investigated. Four scenarios of the biorefinery were evaluated with different extent of mass and energy integration as well as the incorporation of a cogeneration system...
June 15, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28651119/experimental-ultrasonic-characterization-of-polyester-based-materials-for-cultural-heritage-applications
#12
Andres Arciniegas, Loic Martinez, Arnaud Briand, Sophie Prieto, Stéphane Serfaty, Nicolas Wilkie-Chancellier
For several years, the Réunion des musées nationaux - Grand-Palais has produced polyester resin reproductions in order to replace marble sculptures that have weakened by outdoor exposure. These objects are made of a complex multilayered polyester composite material including reinforcements to ensure the mechanical strength of the final structure and mineral fillers that allow to imitate the original aesthetics. However, the final structure also weakens because of constant outdoor exposure and ageing. This observation leads today to conduct research related to the structural health monitoring of reproductions for preventive conservation of cultural heritage...
June 17, 2017: Ultrasonics
https://www.readbyqxmd.com/read/28651106/computer-based-speech-therapy-for-childhood-speech-sound-disorders
#13
REVIEW
Lisa Furlong, Shane Erickson, Meg E Morris
BACKGROUND: With the current worldwide workforce shortage of Speech-Language Pathologists, new and innovative ways of delivering therapy to children with speech sound disorders are needed. Computer-based speech therapy may be an effective and viable means of addressing service access issues for children with speech sound disorders. AIM: To evaluate the efficacy of computer-based speech therapy programs for children with speech sound disorders. METHOD: Studies reporting the efficacy of computer-based speech therapy programs were identified via a systematic, computerised database search...
June 15, 2017: Journal of Communication Disorders
https://www.readbyqxmd.com/read/28651085/evolution-of-monitoring-for-giardia-and-cryptosporidium-in-water
#14
REVIEW
Artemis Efstratiou, Jerry Ongerth, Panagiotis Karanis
This review describes the evolution of monitoring methodology for Cryptosporidium and Giardia in water since the 1970's. Methods in current use for Giardia and Cryptosporidium in water are highlighted, though attention is given to all available published methods by country and continent. The review is intended to stimulate research leading to future improvements and further developments in monitoring methodology for Giardia, Cryptosporidium and other waterborne protozoan parasites in water.
June 18, 2017: Water Research
https://www.readbyqxmd.com/read/28651070/assessment-of-temporal-predictive-models-for-health-care-using-a-formal-method
#15
Ward van Breda, Mark Hoogendoorn, A E Eiben, Matthias Berking
Recent developments in the field of sensor devices provide new possibilities to measure a variety of health related aspects in a precise and fine-grained manner. Subsequently, more empirical data will be generated than ever before. While this greatly improves the opportunities for creating accurate predictive models, other types of models besides the more traditional machine learning approaches can provide insights into temporal relationships in the data. Models that express temporal relationships between states in a mathematical manner are examples of such models...
June 17, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28651018/meta-analysis-of-mirna-expression-profiles-for-prostate-cancer-recurrence-following-radical-prostatectomy
#16
Elnaz Pashaei, Elham Pashaei, Maryam Ahmady, Mustafa Ozen, Nizamettin Aydin
BACKGROUND: Prostate cancer (PCa) is a leading reason of death in men and the most diagnosed malignancies in the western countries at the present time. After radical prostatectomy (RP), nearly 30% of men develop clinical recurrence with high serum prostate-specific antigen levels. An important challenge in PCa research is to identify effective predictors of tumor recurrence. The molecular alterations in microRNAs are associated with PCa initiation and progression. Several miRNA microarray studies have been conducted in recurrence PCa, but the results vary among different studies...
2017: PloS One
https://www.readbyqxmd.com/read/28651010/macrophages-but-not-neutrophils-are-critical-for-proliferation-of-burkholderia-cenocepacia-and-ensuing-host-damaging-inflammation
#17
Jennifer Mesureur, Joana R Feliciano, Nelly Wagner, Margarida C Gomes, Lili Zhang, Monica Blanco-Gonzalez, Michiel van der Vaart, David O'Callaghan, Annemarie H Meijer, Annette C Vergunst
Bacteria of the Burkholderia cepacia complex (Bcc) can cause devastating pulmonary infections in cystic fibrosis (CF) patients, yet the precise mechanisms underlying inflammation, recurrent exacerbations and transition from chronic stages to acute infection and septicemia are not known. Bcc bacteria are generally believed to have a predominant extracellular biofilm life style in infected CF lungs, similar to Pseudomonas aeruginosa, but this has been challenged by clinical observations which show Bcc bacteria predominantly in alveolar macrophages...
June 26, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28651001/pptfdb-a-pigeonpea-transcription-factor-database-for-exploring-functional-genomics-in-legumes
#18
Akshay Singh, Ajay Kumar Sharma, Nagendra Kumar Singh, Tilak Raj Sharma
Pigeonpea (Cajanus cajan L.), a diploid legume crop, is a member of the tribe Phaseoleae. This tribe is descended from the millettioid (tropical) clade of the subfamily Papilionoideae, which includes many important legume crop species such as soybean (Glycine max), mung bean (Vigna radiata), cowpea (Vigna ungiculata), and common bean (Phaseolus vulgaris). It plays major role in food and nutritional security, being rich source of proteins, minerals and vitamins. We have developed a comprehensive Pigeonpea Transcription Factors Database (PpTFDB) that encompasses information about 1829 putative transcription factors (TFs) and their 55 TF families...
2017: PloS One
https://www.readbyqxmd.com/read/28650997/disambiguating-authenticity-interpretations-of-value-and-appeal
#19
Kieran O'Connor, Glenn R Carroll, Balázs Kovács
While shaping aesthetic judgment and choice, socially constructed authenticity takes on some very different meanings among observers, consumers, producers and critics. Using a theoretical framework positing four distinct meanings of socially constructed authenticity-type, moral, craft, and idiosyncratic-we aim to document empirically the unique appeal of each type. We develop predictions about the relationships between attributed authenticity and corresponding increases in the value ascribed to it through: (1) consumer value ratings, (2) willingness to pay, and (3) behavioral choice...
2017: PloS One
https://www.readbyqxmd.com/read/28650980/changes-in-transcript-levels-of-starch-hydrolysis-genes-and-raising-citric-acid-production-via-carbon-ion-irradiation-mutagenesis-of-aspergillus-niger
#20
Wei Hu, Wenjian Li, Hao Chen, Jing Liu, Shuyang Wang, Jihong Chen
The filamentous ascomycete Aspergillus niger is well known for its ability to accumulate citric acid for the hydrolysis of starchy materials. To improve citric acid productivity, heavy ion beam mutagenesis was utilized to produce mutant A.niger strains with enhanced production of citric acid in this work. It was demonstrated that a mutant HW2 with high concentration of citric acid was isolated after carbon ion irradiation with the energy of 80Mev/μ, which was obvious increase higher than the original strain from liquefied corn starch as a feedstock...
2017: PloS One
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