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https://www.readbyqxmd.com/read/29055268/early-age-of-e-cigarette-use-onset-mediates-the-association-between-impulsivity-and-e-cigarette-use-frequency-in-youth
#1
Krysten W Bold, Meghan E Morean, Grace Kong, Patricia Simon, Deepa R Camenga, Dana A Cavallo, Suchitra Krishnan-Sarin
BACKGROUND: Identifying risk factors for youth e-cigarette use is critical, given high rates of e-cigarette use and unknown health effects of long-term use. The current study examined whether an early age of onset of e-cigarette use mediates the association between impulsivity and e-cigarette frequency. METHODS: Cross-sectional survey data of e-cigarette users (n=927) were collected from 8 high schools in southeastern Connecticut. The sample was 44.7% female (mean age 16...
October 13, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29055262/emergency-residential-care-settings-a-model-for-service-assessment-and-design
#2
João Graça, Maria Manuela Calheiros, Joana Nunes Patrício, Eunice Vieira Magalhães
There have been calls for uncovering the "black box" of residential care services, with a particular need for research focusing on emergency care settings for children and youth in danger. In fact, the strikingly scant empirical attention that these settings have received so far contrasts with the role that they often play as gateway into the child welfare system. To answer these calls, this work presents and tests a framework for assessing a service model in residential emergency care. It comprises seven studies which address a set of different focal areas (e...
October 12, 2017: Evaluation and Program Planning
https://www.readbyqxmd.com/read/29055235/a-traditional-american-indian-death-ritual-developing-nursing-knowledge-through-aesthetic-exposure
#3
Barbara K Charbonneau-Dahlen
The theoretical and practical application of Boykin and Schoenhofer's Nursing as Caring: A Model for Transforming Practice (2001) provided a framework for the exploration of an aesthetic project of quilting, which was undertaken in order to explain the death journey for a cherished mentor of American Indian nursing students. In particular, the nursing situation was used to guide the making of the quilt sampler. Aesthetics nested into the teaching-learning process became another way to help students solidify their professional self-identity as caring persons...
October 12, 2017: Nurse Education in Practice
https://www.readbyqxmd.com/read/29055184/predict-protein-structural-class-by-incorporating-two-different-modes-of-evolutionary-information-into-chou-s-general-pseudo-amino-acid-composition
#4
Yunyun Liang, Shengli Zhang
Structural class is an important attribute of protein, which plays an important role in both the experiment and theoretical research of protein science. Prediction of protein structural classes has been a challenging task, specifically for low-similarity datasets. In this paper, we develop a feature extraction method PSSS-SOMA-PSSM by incorporating two different modes of evolutionary information into Chou's general pseudo amino acid composition (PseAAC) based on predicted secondary structure sequence (PSSS) and position-specific scoring matrix (PSSM)...
October 7, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29055149/the-implementation-of-knowledge-dissemination-in-the-prevention-of-occupational-skin-diseases
#5
A Wilke, U Bollmann, S Cazzaniga, A Hübner, S M John, J Karadzinska-Bislimovska, D Mijakoski, D Šimić, D Simon, F Sonsmann, S Stoleski, P Weinert, B Wulfhorst
BACKGROUND: Occupational skin diseases (OSD) have a high medical, social, economic and political impact. Knowledge dissemination from research activities to key stakeholders involved in health care is a prerequisite to make prevention effective. OBJECTIVES: To study and prioritize different activity fields and stakeholders that are involved in the prevention of OSD, to reflect on their inter-relationships, to develop a strategic approach for knowledge dissemination and to develop a hands-on tool for OSD prevention projects METHODS: Seven different activity fields that are relevant in the prevention of OSD have been stepwise identified...
October 21, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29055079/health-sciences-libraries-in-the-united-states-new-directions
#6
Barbara A Epstein
This article is the third in a series in this regular feature. The intention of the series is to look at important global developments in health science libraries. These articles will serve as a road map, describing the key changes in the field and exploring factors driving these changes. The present article by the current president of the Medical Library Association outlines two important developments in the United States. The topics chosen for consideration are national initiatives in the United States impacting health sciences libraries and librarians and enhanced roles for U...
October 21, 2017: Health Information and Libraries Journal
https://www.readbyqxmd.com/read/29054980/one-year-language-outcomes-in-toddlers-with-language-delays-an-rct-follow-up
#7
Lauren H Hampton, Ann P Kaiser, Megan Y Roberts
OBJECTIVES: The current study is a 1-year follow-up analysis of data from a randomized controlled trial of Enhanced Milieu Teaching (EMT) for toddlers with language delays. Outcomes and predictors of child language and parent intervention implementation were examined 6 and 12 months after the end of the intervention. METHODS: Toddlers with language delays were recruited from the community, and 97 toddlers and parents were randomly assigned to receive usual community treatments or a 3-month EMT intervention with parent training...
October 20, 2017: Pediatrics
https://www.readbyqxmd.com/read/29054791/initial-validation-of-the-exercise-chronic-pain-acceptance-questionnaire
#8
James D Sessford, Lawrence R Brawley
BACKGROUND AND AIMS: Pain acceptance, measured by the chronic pain acceptance questionnaire (CPAQ), is related to exercise adherence for those with arthritis. The CPAQ measure has 20 items comprising two subscales -- pain willingness and activities engagement about pursuing "valued daily activities" despite pain. However, exercise is not specified as a valued activity and respondents may be considering other activities raising generalizability and strength of prediction concerns. METHODS: Accordingly, a modified CPAQ solely for exercise (CPAQ-E) was developed to heighten salience to pursuit of exercise in the face of pain...
October 17, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29054784/developing-a-xenograft-human-tumor-model-in-immunocompetent-mice
#9
Matthew T Basel, Sanjeev Narayanan, Chanran Ganta, Tej B Shreshta, Alejandro Marquez, Marla Pyle, Jennifer Hill, Stefan H Bossmann, Deryl L Troyer
Animal models are essential to cancer research, but current xenograft models are limited in their utility especially due to the lack of an immune system. Here we demonstrate that a xenograft tumor model can be developed in immunocompetent mice by tolerizing murine fetuses to human tumor cells. A375 human melanoma cells were injected into day E14 fetuses and after birth mice were challenged with A375 cells to determine their ability to develop tumors. Intravenous injections of cells resulted in metastatic-like lung tumors, which were verified to be human in origin by immunohistochemistry and PCR...
October 17, 2017: Cancer Letters
https://www.readbyqxmd.com/read/29054753/risk-of-fracture-in-transfusion-na%C3%A3-ve-thalassemia-population-a-nationwide-population-based-retrospective-cohort-study
#10
Yu-Guang Chen, Chieh-Sheng Lu, Te-Yu Lin, Cheng-Li Lin, Huey-En Tzeng, Chun-Hao Tsai
In thalassemia major or transfusion-dependent thalassemia patients, osteoporosis-related bone complications such as fracture events are common. However, no studies have investigated the risk of fracture in transfusion-naïve thalassemia population. Therefore, we conducted a longitudinal nationwide cohort study to determine whether this population has an increased risk of fracture. This nationwide, population-based cohort study analyzed data from 1998 to 2010 obtained from the Taiwanese National Health Insurance Research Database, with a follow-up period extending until the end of 2011...
October 17, 2017: Bone
https://www.readbyqxmd.com/read/29054747/u-s-army-physical-demands-study-identification-and-validation-of-the-physically-demanding-tasks-of-combat-arms-occupations
#11
Marilyn A Sharp, Bruce S Cohen, Michael W Boye, Stephen A Foulis, Jan E Redmond, Kathleen Larcom, Jay R Hydren, Deborah L Gebhardt, Maria C Canino, Bradley J Warr, Edward J Zambraski
OBJECTIVES: In 2013, the U.S. Army began developing physical tests to predict a recruit's ability to perform the critical, physically demanding tasks (CPDTs) of combat arms jobs previously not open to women. The purpose of this paper is to describe the methodology and results of analyses of the accuracy and inclusiveness of the critical physically demanding task list. While the job analysis included seven combat arms jobs, only data from the 19D Cavalry Scout occupation are presented as the process was similar for all seven jobs...
October 5, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/29054739/engagement-and-role-of-surgical-trainees-in-global-surgery-consensus-statement-and-recommendations-from-the-association-of-surgeons-in-training
#12
EDITORIAL
Helen M Mohan, Edward Fitzgerald, Vimal Gokani, Paul Sutton, Rhiannon Harries, Robert Bethune, Frank D McDermott
BACKGROUND: There is a wide chasm in access to essential and emergency surgery between high and low/middle income countries (LMICs). Surgeons worldwide are integral to solutions needed to address this imbalance. Involving surgical trainees, who represent the future of surgery, is vital to this endeavour. The Association of Surgeons in Training (ASiT) is an independent charity that support surgical trainees of all ten surgical specialties in the UK and Ireland. ASiT convened a consensus meeting at the ASiT conference in Liverpool 2016 to discuss trainee engagement with global surgery, including potential barriers and solutions...
October 17, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/29054733/disrupted-ionic-homeostasis-in-ischemic-stroke-and-new-therapeutic-targets
#13
REVIEW
Hui-Jie Hu, Mingke Song
BACKGROUND: Stroke is a leading cause of long-term disability. All neuroprotectants targeting excitotoxicity have failed to become stroke medications. In order to explore and identify new therapeutic targets for stroke, we here reviewed present studies of ionic transporters and channels that are involved in ischemic brain damage. METHOD: We surveyed recent literature from animal experiments and clinical reports in the databases of PubMed and Elsevier ScienceDirect to analyze ionic mechanisms underlying ischemic cell damage and suggest promising ideas for stroke therapy...
October 17, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29054731/the-impact-of-obesity-and-hypercaloric-diet-consumption-on-anxiety-and-emotional-behavior-across-the-lifespan
#14
REVIEW
Kathryn D Baker, Amy Loughman, Sarah J Spencer, Amy C Reichelt
Obesity is an increasing problem in young people. Childhood obesity and overweight have increased rapidly on a global scale, and have tripled in the past 30 years, to affect approximately one in five children. Diets high in refined fats and sugar are a major contributor to the development of obesity, and the effects of such obesity-inducing hypercaloric diets on brain function may contribute to the high prevalence of anxiety disorders in people with obesity. Anxiety disorders typically emerge in childhood and adolescence, and symptoms often continue into adulthood...
October 17, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29054690/removable-rigid-dressings-for-postoperative-management-of-transtibial-amputations-a-review-of-published-evidence
#15
REVIEW
James P Reichmann, Phillip M Stevens, John Rheinstein, Christopher D Kreulen
Forty years of clinical experience and peer reviewed research studies support the use of non-weight bearing removable rigid dressings (RRD) as an effective means of post-operative management of transtibial amputations. We reviewed the published medical evidence regarding the use of RRDs as a postoperative management strategy, culminating in an evidence-based practice recommendation. Published peer reviewed literature on the topic was searched and classified by level of evidence based on the research design utilizing the scale recommended by the PM&R Journal (level I through V)...
October 17, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29054568/genetic-epidemiology-of-ovarian-cancer-and-prospects-for-polygenic-risk-prediction
#16
REVIEW
Michelle R Jones, Daniella Kamara, Beth Y Karlan, Paul D P Pharoah, Simon A Gayther
Epithelial ovarian cancer (EOC) is a heterogeneous disease with a major heritable component. The different histotypes of invasive disease - high grade serous, clear cell, endometrioid and mucinous - are associated with different underlying genetic susceptibility and epidemiological and lifestyle risk factors, all of which contribute to the different biology and clinical characteristics of each histotype. A combination of familial and population based sequencing studies, and genome wide association studies (GWAS) have identified a range of genetic susceptibility alleles for EOC comprising rare but highly penetrant genes (e...
October 17, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29054504/proteomics-in-plasma-of-ovariectomized-rats-and-those-exposed-to-estradiol-valerate
#17
Hai Jiang, Wenpei Bai, Wenjuan Wang, Ke Wang, Jing Jia, Jing Zhang, He Diao, Lihua Qin
The menopausal period, an inevitable physiological process for women, is frequently associated with physiological and psychological dysfunction attributable to substantial fluctuation and gradual decrease in female hormones induced by ovarian failure, leading to corresponding symptoms and diseases that impact multiple systems in the body to varying degrees. As prior studies have focused primarily on menopausal syndrome-related pathophysiological changes and hormone replacement therapy effects, here we approached menopausal disease incidence risk and pathogenesis through systemic plasma proteomics analysis...
October 17, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29054474/deubiquitylating-enzymes-as-cancer-stem-cell-therapeutics
#18
REVIEW
Saba Haq, Bharathi Suresh, Suresh Ramakrishna
The focus of basic and applied research on core stem cell transcription factors has paved the way to initial delineation of their characteristics, their regulatory mechanisms, and the applicability of their regulatory proteins for protein-induced pluripotent stem cells (protein-IPSC) generation and in further clinical settings. Striking parallels have been observed between cancer stem cells (CSCs) and stem cells. For the maintenance of stem cells and CSC pluripotency and differentiation, post translational modifications (i...
October 17, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29054397/tolerance-in-clinical-liver-transplantation
#19
REVIEW
Josh Levitsky, Sandy Feng
While advances in immunosuppressive therapy have lowered the rate of acute rejection following liver transplantation, the consequence has been an increase in morbidity and mortality related to the lifelong need for maintenance immunosuppression. These complications include an increased risk of malignancy, infection, metabolic disorders, and chronic kidney disease, as well as high health care costs associated with these therapies and the required drug monitoring. Given these issues, most clinicians attempt trial and error dose minimization with variable success rates, and there has been significant interest in full drug withdrawal in select patients through research protocols...
October 17, 2017: Human Immunology
https://www.readbyqxmd.com/read/29054386/interlaced-size-exclusion-chromatography-for-faster-protein-analysis
#20
Julia Kahle, Hermann Wätzig
In this research note, interlaced Size Exclusion Chromatography (SEC) is used to shorten the duration of protein analysis. The applied method has a threefold higher sample throughput than comparable ones using conventional SEC. Further important advantages are the identical area's precision and the preservation of protein stability. Two different applications are presented where a short time interval of analysis is very important. One application is the determination of aggregates of monoclonal antibodies (mAbs)...
October 17, 2017: European Journal of Pharmaceutics and Biopharmaceutics
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