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https://www.readbyqxmd.com/read/28110470/thermal-control-weather-and-aging
#1
REVIEW
Alexandra Schneider, Regina Rückerl, Susanne Breitner, Kathrin Wolf, Annette Peters
PURPOSE OF THE REVIEW: The purpose of this review is to highlight the latest developments in the field of weather and health with a focus on the elderly. The current state of knowledge is summarized and open questions and emerging fields of research are discussed. RECENT FINDINGS: It is expected that climate change will lead to higher global average surface temperatures and more extreme climatic conditions. Previous studies have shown that non-optimal temperatures are associated with increased morbidity and mortality, specifically in elderly people...
January 21, 2017: Current Environmental Health Reports
https://www.readbyqxmd.com/read/28110459/calcium-phosphate-ceramics-and-polysaccharide-based-hydrogel-scaffolds-combined-with-mesenchymal-stem-cell-differently-support-bone-repair-in-rats
#2
Sophie Frasca, Françoise Norol, Catherine Le Visage, Jean-Marc Collombet, Didier Letourneur, Xavier Holy, Elhadi Sari Ali
Research in bone tissue engineering is focused on the development of alternatives to autologous bone grafts for bone reconstruction. Although multiple stem cell-based products and biomaterials are currently being investigated, comparative studies are rarely achieved to evaluate the most appropriate approach in this context. Here, we aimed to compare different clinically relevant bone tissue engineering methods and evaluated the kinetic repair and the bone healing efficiency supported by mesenchymal stem cells and two different biomaterials, a new hydrogel scaffold and a commercial hydroxyapatite/tricalcium phosphate ceramic, alone or in combination...
February 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28110455/influence-of-environmental-and-anthropogenic-factors-at-the-bottom-sediments-in-a-doce-river-tributary-in-brazil
#3
Deyse Almeida Dos Reis, Aníbal da Fonseca Santiago, Laura Pereira Nascimento, Hubert Mathias Peter Roeser
In developing countries, it is uncommon to find watersheds that have been the object of detailed environmental studies. It makes the assessment of the magnitude of environmental impacts and pollution of these sites difficult. This research demonstrated ways to understand the dynamics of river bottom sediments contamination, even for watersheds with a lack of environmental data. Based on geochemical affinity, we conducted a comprehensive study on the concentration of metals and metalloids. Then, we discussed the probable origin of the concentration of these elements at the bottom sediment along the Matipó River...
January 22, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28110411/development-of-the-siope-dipg-network-registry-and-imaging-repository-a-collaborative-effort-to-optimize-research-into-a-rare-and-lethal-disease
#4
Sophie E M Veldhuijzen van Zanten, Joshua Baugh, Brooklyn Chaney, Dennis De Jongh, Esther Sanchez Aliaga, Frederik Barkhof, Johan Noltes, Ruben De Wolf, Jet Van Dijk, Antonio Cannarozzo, Carin M Damen-Korbijn, Jan A Lieverst, Niclas Colditz, Marion Hoffmann, Monika Warmuth-Metz, Brigitte Bison, David T W Jones, Dominik Sturm, Gerrit H Gielen, Chris Jones, Esther Hulleman, Raphael Calmon, David Castel, Pascale Varlet, Géraldine Giraud, Irene Slavc, Stefaan Van Gool, Sandra Jacobs, Filip Jadrijevic-Cvrlje, David Sumerauer, Karsten Nysom, Virve Pentikainen, Sanna-Maria Kivivuori, Pierre Leblond, Natasha Entz-Werle, Andre O von Bueren, Antonis Kattamis, Darren R Hargrave, Péter Hauser, Miklos Garami, Halldora K Thorarinsdottir, Jane Pears, Lorenza Gandola, Giedre Rutkauskiene, Geert O Janssens, Ingrid K Torsvik, Marta Perek-Polnik, Maria J Gil-da-Costa, Olga Zheludkova, Liudmila Shats, Ladislav Deak, Lidija Kitanovski, Ofelia Cruz, Andres Morales La Madrid, Stefan Holm, Nicolas Gerber, Rejin Kebudi, Richard Grundy, Enrique Lopez-Aguilar, Marta Zapata-Tarres, John Emmerik, Tim Hayden, Simon Bailey, Veronica Biassoni, Maura Massimino, Jacques Grill, William P Vandertop, Gertjan J L Kaspers, Maryam Fouladi, Christof M Kramm, Dannis G van Vuurden
Diffuse intrinsic pontine glioma (DIPG) is a rare and deadly childhood malignancy. After 40 years of mostly single-center, often non-randomized trials with variable patient inclusions, there has been no improvement in survival. It is therefore time for international collaboration in DIPG research, to provide new hope for children, parents and medical professionals fighting DIPG. In a first step towards collaboration, in 2011, a network of biologists and clinicians working in the field of DIPG was established within the European Society for Paediatric Oncology (SIOPE) Brain Tumour Group: the SIOPE DIPG Network...
January 21, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28110306/insufficient-cardiovascular-research-development-funding
#5
David Garcia-Dorado
No abstract text is available yet for this article.
January 1, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28110285/validation-of-a-clinical-screening-instrument-for-tumour-predisposition-syndromes-in-patients-with-childhood-cancer-tups-protocol-for-a-prospective-observational-multicentre-study
#6
Floor A M Postema, Saskia M J Hopman, Corianne A J M de Borgie, Peter Hammond, Raoul C Hennekam, Johannes H M Merks, Cora M Aalfs, Jakob K Anninga, Lieke Pv Berger, Fonnet E Bleeker, Eveline Sjm de Bont, Corianne Ajm de Borgie, Charlotte J Dommering, Natasha Ka van Eijkelenburg, Peter Hammond, Raoul C Hennekam, Marry M van den Heuvel-Eibrink, Saskia Mj Hopman, Marjolijn Cj Jongmans, Wijnanda A Kors, Tom Gw Letteboer, Jan Lcm Loeffen, Johannes Hm Merks, Maran Jw Olderode-Berends, Floor Am Postema, Anja Wagner
INTRODUCTION: Recognising a tumour predisposition syndrome (TPS) in patients with childhood cancer is of significant clinical relevance, as it affects treatment, prognosis and facilitates genetic counselling. Previous studies revealed that only half of the known TPSs are recognised during standard paediatric cancer care. In current medical practice it is impossible to refer every patient with childhood cancer to a clinical geneticist, due to limited capacity for routine genetic consultation...
January 20, 2017: BMJ Open
https://www.readbyqxmd.com/read/28110256/ethical-experiential-learning-in-medical-nursing-and-allied-health-education-a-narrative-review
#7
REVIEW
Sandra Grace, Ev Innes, Narelle Patton, Lynette Stockhausen
: Students enrolled in medical, nursing and health science programs often participate in experiential learning in their practical classes. Experiential learning includes peer physical examination and peer-assisted learning where students practise clinical skills on each other. OBJECTIVES: To identify effective strategies that enable ethical experiential learning for health students during practical classes. DESIGN: A narrative review of the literature...
January 10, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/28110217/induced-dopaminergic-neurons-a-new-promise-for-parkinson-s-disease
#8
Zhimin Xu, Xingkun Chu, Houbo Jiang, Haley Schilling, Shengdi Chen, Jian Feng
Motor symptoms that define Parkinson's disease (PD) are caused by the selective loss of nigral dopaminergic (DA) neurons. Cell replacement therapy for PD has been focused on midbrain DA neurons derived from human fetal mesencephalic tissue, human embryonic stem cells (hESC) or human induced pluripotent stem cells (iPSC). Recent development in the direct conversion of human fibroblasts to induced dopaminergic (iDA) neurons offers new opportunities for transplantation study and disease modeling in PD. The iDA neurons are generated directly from human fibroblasts in a short period of time, bypassing lengthy differentiation process from human pluripotent stem cells and the concern for potentially tumorigenic mitotic cells...
January 16, 2017: Redox Biology
https://www.readbyqxmd.com/read/28110137/marijuana-protective-behavioral-strategies-as-a-moderator-of-the-effects-of-risk-protective-factors-on-marijuana-related-outcomes
#9
Adrian J Bravo, Amber M Anthenien, Mark A Prince, Matthew R Pearson
Given that both marijuana use and cannabis use disorder peak among college students, it is imperative to determine the factors that may reduce risk of problematic marijuana use and/or the development of cannabis use disorder. From a harm reduction perspective, the present study examined whether the use of marijuana protective behavioral strategies (PBS) buffers or amplifies the effects of several distinct risk and protective factors that have been shown to relate to marijuana-related outcomes (i.e., use frequency and consequences)...
January 8, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28110108/boys-are-not-exempt-sexual-exploitation-of-adolescents-in-sub-saharan-africa
#10
Jones K Adjei, Elizabeth M Saewyc
Research on youth sexual exploitation in Africa has largely neglected the experiences of exploited boys. To date, much of the research in sub-Saharan Africa continues to consider boys mainly as exploiters but not as exploited. Using the only publicly available population-based surveys from the National Survey of Adolescents, conducted in four sub-Saharan African countries - Burkina Faso, Ghana, Malawi, and Uganda-we assessed factors associated with transactional sexual behaviour among never-married adolescent boys and girls...
January 18, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28110083/preconditioning-in-neuroprotection-from-hypoxia-to-ischemia
#11
REVIEW
Sijie Li, Adam Hafeez, Fatima Noorulla, Xiaokun Geng, Guo Shao, Changhong Ren, Guowei Lu, Heng Zhao, Yuchuan Ding, Xunming Ji
Sublethal hypoxic or ischemic events can improve the tolerance of tissues, organs, and even organisms from subsequent lethal injury caused by hypoxia or ischemia. This phenomenon has been termed hypoxic or ischemic preconditioning (HPC or IPC) and is well established in the heart and the brain. This review aims to discuss HPC and IPC with respect to their historical development and advancements in our understanding of the neurochemical basis for their neuroprotective role. Through decades of collaborative research and studies of HPC and IPC in other organ systems, our understanding of HPC and IPC-induced neuroprotection has expanded to include: early- (phosphorylation targets, transporter regulation, interfering RNA) and late- (regulation of genes like EPO, VEGF, and iNOS) phase changes, regulators of programmed cell death, members of metabolic pathways, receptor modulators, and many other novel targets...
January 18, 2017: Progress in Neurobiology
https://www.readbyqxmd.com/read/28110072/structuring-of-composite-hydrogel-bioadhesives-and-its-effect-on-properties-and-bonding-mechanism
#12
Oded Pinkas, Daniella Goder, Roni Noyvirt, Sivan Peleg, Maayan Kahlon, Meital Zilberman
: Bioadhesives are polymeric hydrogels that can adhere to a tissue after crosslinking and are an essential element in nearly all surgeries worldwide. Several bioadhesives are commercially available. However, none of them are ideal. The main limitation of current tissue adhesives is the tradeoff between biocompatibility and mechanical strength, especially in wet hemorrhagic environments. Our novel bioadhesives are based on the natural polymers gelatin (coldwater fish) and alginate, crosslinked by carbodiimide (EDC)...
January 18, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28110066/bioactive-nutrients-time-for-tolerable-upper-intake-levels-to-address-safety
#13
Allison Yates, John W Erdman, Andrew Shao, Laurie Dolan, James C Griffiths
There is increasing interest by consumers, researchers, and regulators into the roles that certain bioactive compounds, derived from plants and other natural sources, can play in health maintenance and promotion, and even prolonging a productive quality of life. Research has rapidly emerged suggesting that a wide range of compounds and mixtures in and from plants (such as fruits and vegetables, tea and cocoa) and animals (such as fish and probiotics) may exert substantial health benefits. There is interest in exploring the possibility of establishing recommended intakes or dietary guidance for certain bioactive substances to help educate consumers...
January 18, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28110053/development-and-optimization-of-an-in-vitro-cultivation-protocol-allows-for-isolation-of-borrelia-miyamotoi-from-patients-with-hard-tick-borne-relapsing-fever
#14
Joris Koetsveld, Nadezhda M Kolyasnikova, Alex Wagemakers, Marina G Toporkova, Denis S Sarksyan, Anneke Oei, Alexander E Platonov, Joppe W Hovius
OBJECTIVES: Borrelia miyamotoi has been shown to infect humans in Eurasia and North America causing hard tick-borne relapsing fever (HTBRF). In vitro cultivation of B. miyamotoi was described recently; however, clinical isolation of relapsing fever Borrelia is cumbersome. Our aim was to develop a straightforward protocol enabling B. miyamotoi isolation directly from blood of patients. METHODS: MKP-F media, with or without anticoagulants, or blood from healthy human volunteers, was spiked with B...
January 18, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28110042/recent-advances-in-compartmentalized-synthetic-architectures-as-drug-carriers-cell-mimics-and-artificial-organelles
#15
REVIEW
M J York-Duran, M Godoy-Gallardo, C Labay, A J Urquhart, T L Andresen, L Hosta-Rigau
Compartmentalization is a key feature of biological cells which conduct their metabolic activity in individual steps isolated in distinct, separated compartments. The creation of architectures containing multiple compartments with a structure that resembles that of a biological cell has generated significant research attention and these assemblies are proposed as candidate materials for a range of biomedical applications. In this Review article, the recent successes of multicompartment architectures as carriers for the delivery of therapeutic cargo or the creation of micro- and nanoreactors that mimic metabolic activities, thus acting as artificial cells or organelles, are discussed...
January 16, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28110014/nanosilver-as-a-disinfectant-in-dental-unit-waterlines-assessment-of-the-physicochemical-transformations-of-the-agnps
#16
Alireza Gitipour, Souhail R Al-Abed, Stephen W Thiel, Kirk G Scheckel, Thabet Tolaymat
Dental unit water lines (DUWL) are susceptible to biofilm development and bacterial growth leading to water contamination, causing health and ecological effects. This study monitors the interactions between a commonly used nanosilver disinfectant (ASAP-AGX-32, an antimicrobial cleaner for dental units, 0.0032% Ag) and biofilm development in DUWL. To simulate the disinfection scenario, an in-house DUWL model was assembled and biofilm accumulation was allowed. Subsequent to biofilm development, the disinfection process was performed according to the manufacturer's instructions...
January 12, 2017: Chemosphere
https://www.readbyqxmd.com/read/28110011/distributions-of-persistent-organic-contaminants-in-sediments-and-their-potential-impact-on-macrobenthic-faunal-community-of-the-geum-river-estuary-and-saemangeum-coast-korea
#17
Seo Joon Yoon, Seongjin Hong, Bong-Oh Kwon, Jongseong Ryu, Chang-Hee Lee, Jungho Nam, Jong Seong Khim
Over the last 30 years, the Geum River Estuary and Saemangeum Coast have been subject to major environmental changes, including dike construction, reclamation, and development of industrial complexes. This study aimed to: 1) investigate the occurrence of polycyclic aromatic hydrocarbons (PAHs), alkylphenols (APs), and styrene oligomers (SOs), 2) identify the sources of sedimentary organic matter, and 3) determine key environmental factors controlling the macrozoobenthos community structure. A total of 58 surface sediments were collected from the estuary and coastal area in 2014...
January 9, 2017: Chemosphere
https://www.readbyqxmd.com/read/28109965/a-novel-acidic-ph-fluorescent-probe-based-on-a-benzothiazole-derivative
#18
Qiujuan Ma, Xian Li, Suxiang Feng, Beibei Liang, Tiqiang Zhou, Min Xu, Zhuoyi Ma
A novel acidic pH fluorescent probe 1 based on a benzothiazole derivative has been designed, synthesized and developed. The linear response range covers the acidic pH range from 3.44 to 6.46, which is valuable for pH researches in acidic environment. The evaluated pKa value of the probe 1 is 4.23. The fluorescence enhancement of the studied probe 1 with an increase in hydrogen ions concentration is based on the hindering of enhanced photo-induced electron transfer (PET) process. Moreover, the pH sensor possesses a highly selective response to H(+) in the presence of metal ions, anions and other bioactive small molecules which would be interfere with its fluorescent pH response...
January 12, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28109958/optical-barcoding-for-single-clone-tracking-to-study-tumor-heterogeneity
#19
Malte Mohme, Cecile L Maire, Kristoffer Riecken, Svenja Zapf, Tim Aranyossy, Manfred Westphal, Katrin Lamszus, Boris Fehse
Intratumoral heterogeneity has been identified as one of the strongest drivers of treatment resistance and tumor recurrence. Therefore, investigating the complex clonal architecture of tumors over time has become a major challenge in cancer research. We developed a new fluorescent "optical barcoding" technique that allows fast tracking, identification, and quantification of live cell clones in vitro and in vivo using flow cytometry (FC). We optically barcoded two cell lines derived from malignant glioma, an exemplary heterogeneous brain tumor...
January 18, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28109951/a-cognitive-approach-for-design-of-a-multimedia-informed-consent-video-and-website-in-pediatric-research
#20
Holly Antal, H Timothy Bunnell, Suzanne M McCahan, Chris Pennington, Tim Wysocki, Kathryn Blake
OBJECTIVE: Poor participant comprehension of research procedures following the conventional face-to-face consent process for biomedical research is common. We describe the development of a multimedia informed consent video and website that incorporates cognitive strategies to enhance comprehension of study related material directed to parents and adolescents. MATERIALS AND METHODS: A multidisciplinary team was assembled for development of the video and website that included human subjects professionals; psychologist researchers; institutional video and web developers; bioinformaticians and programmers; and parent and adolescent stakeholders...
January 18, 2017: Journal of Biomedical Informatics
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